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Jason Pomerantz Awarded 5-year $1.7M NIH Grant to Investigate Muscle Stem Cells for Therapeutic Potential | UCSF Department of Surgery
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class="breadcrumbs__link" href="/">Home</a> </li> <span class="breadcrumbs__spacer">/</span> <li class="breadcrumbs__item"> <a class="breadcrumbs__link" href="/news">News & Events</a> </li> <span class="breadcrumbs__spacer">/</span> <li class="breadcrumbs__item"> Jason Pomerantz Awarded 5-year $1.7M NIH Grant To Investigate Muscle Stem Cells For Therapeutic Potential </li> </ol> </div> </nav> </div> </div> <div class="main l-content right-sidebar-only"> <div class="page-content-outer-wrap"> <div class="region region-title"> <div id="block-dos-page-title" class="block block-core block-page-title-block"> <h1 class="page-title"> <div class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank">Jason Pomerantz Awarded 5-year $1.7M NIH Grant to Investigate Muscle Stem Cells for Therapeutic Potential</div> </h1> </div> </div> <div class="page-content-inner-wrap"> <div class="page-content"> <div class="region region-content"> <div id="block-dos-content" class="block block-system block-system-main-block"> <article data-history-node-id="9931" class="node node--type-news node--view-mode-full"> <div class="node__content"> <div class="field field--name-field-news-source field--type-entity-reference field--label-hidden field__item">Pomerantz Lab</div> <div class="field field--name-field-date-published field--type-datetime field--label-hidden field__item">March 13, 2018</div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><a href="http://pomerantzlab.surgery.ucsf.edu/lab-members/director/jason-h-pomerantz,-md.aspx" title="Jason H. Pomerantz, M.D.">Jason H. Pomerantz, M.D.</a>, associate professor of surgery and surgical director of the UCSF Craniofacial Center, has been awarded a 5-year $1.7M R01 grant from National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to study muscle stem cells, a subpopulation of muscle progenitors that are focal points of vulnerability in muscle dysfunction from disease, trauma or aging.</p> <h2>Project Narrative</h2> <p><img width="235" height="354" src="/sites/default/files/umbraco/media/10581384/jason-in-lab.jpg" alt="Jason In Lab" class="imgRightAlign" caption="Jason Pomerantz, MD. Photo by Susan Merrell" loading="lazy">"Muscle dysfunction from disease, trauma or aging, a major health care burden not adequately alleviated by available therapies, could be greatly reduced by treatments that directly address regeneration pathophysiology by capitalizing on muscle stem cells. Muscle stem cells are a subpopulation of incompletely understood muscle progenitors called satellite cells that are focal points of vulnerability in muscle aging and disease states, and in turn, promising therapeutic targets. The proposed research will result in a deeper understanding of the populations of human satellite cells that exist naturally in a broad age range of adults, a necessary foundation for developing muscle stem cell therapeutic applications."</p> <p class="bulletArrow"><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9423409&icde=37812528">View full abstract at NIH RePORTER</a></p> <h2><span>About the Pomerantz Lab</span></h2> <p>The <a href="https://pomerantzlab.ucsf.edu" title="Pomerantz Lab">Pomerantz Lab </a><span>studies basic and translational aspects of tissue regeneration. </span><span>With foundations in muscle and cancer biology, the lab investigates regenerative mechanisms including stem cell development and de-differentiation. Using model organisms such as zebrafish and mice, and extending discoveries to human cells and tissues, the lab hopes to gain fundamental insight that can be translated into clinical advances, notably solving the structural and reconstructive problems of the limbs, face, and head, whether congenital or acquired.</span></p></div> <div class="field field--name-field-tags field--type-entity-reference field--label-above"> <div class="field__label">Tags:</div> <div class="field__items"> <div class="field__item">NIH Funding</div> </div> </div> </div> </article> </div> </div> </div> </div> </div> <aside id="sidebar-right" class="sidebar-second" role="complementary"> <div class="region region-sidebar-right"> <div class="views-element-container block block-views block-views-blockmentioned-in-this-story-block-1" id="block-views-block-mentioned-in-this-story-block-1"> <h2>Mentioned in this Story</h2> <div region="sidebar_right"><div class="view view-mentioned-in-this-story view-id-mentioned_in_this_story view-display-id-block_1 js-view-dom-id-20225e644f15e05002780af0429739fe2cc7588e28fc69af0dcf5afe601e7340"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-primary-image"><div class="field-content"> <article class="media media--type-image media--view-mode-bio-card-image" aria-label="Image about Dr Jason Pomerantz 144x192 headshot"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/bio_card_image/public/2024-06/dr-jason-pomerantz-md-144x192.jpg.webp?itok=p5rpjr9r 135w, /sites/default/files/styles/bio_card_image_2x/public/2024-06/dr-jason-pomerantz-md-144x192.jpg.webp?itok=NuRZ0BGQ 270w" sizes="8.4375rem" width="270" height="360" src="/sites/default/files/styles/bio_card_image/public/2024-06/dr-jason-pomerantz-md-144x192.jpg.webp?itok=p5rpjr9r" alt="Dr Jason Pomerantz 144x192 headshot" /> </div> </article> </div></div><div class="views-field views-field-title"><span class="field-content"><a href="/bio/jason-h-pomerantz-md" hreflang="en">Jason H. Pomerantz, MD</a></span></div><div class="views-field views-field-field-academic-working-titles"><div class="field-content"><p>Professor of Surgery<br>Division of Plastic and Reconstructive Surgery<br>Co-Director, Craniofacial Center Benioff Children鈥檚 Hospitals<br>Co-chair, Department of Surgery research Committee<br>Director, Pomerantz Laboratory</p></div></div></div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blocksidebar-components-block-1" id="block-views-block-sidebar-components-block-1"> <div region="sidebar_right"><div class="view view-sidebar-components view-id-sidebar_components view-display-id-block_1 js-view-dom-id-afb1c32a29271cd84b346a9bad20de8145d70079a4b49bfd51bd1e2ecb141dbf"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-sidebar-components"><div class="field-content"></div></div></div> </div> </div> </div> </div> </div> </aside> </div> </main> <footer class="footer"> <div class="footer__container"> <div class="footer__wrap"> <div class="footer__inner"> <div class="footer__first"> <figure class="footer__logo"> <a class="footer__logo-link" href="/" title="Home UCSF Department of Surgery"> <picture class="footer__logo-image"> <img class="footer-logo__img" src="/themes/custom/dos/dist/icon/svg/footer-logo.svg" alt="UCSF Footer Logo" width="160" height="79"> </picture> </a> </figure> </div> <div class="footer__second"> <nav role="navigation" aria-labelledby="Footer Menu" id="block-typefooterresearch" class="block block-menu navigation menu--type-footer--research menu--footer"> <h2 class="visually-hidden" id="block-typefooterresearch-menu">Type Footer - 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