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25 - Italian Researchers Identify New SARS-CoV-2 Gene Variants That Provide Clues to Coronavirus's Epidemiology

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class="cmp-tfc-text"> <div id="text-239424405" class="cmp-text"> <h1>Italian researchers identify new SARS-CoV-2 gene variants that provide clues to Coronavirus's Epidemiology</h1> <p>Scientists say early data, generated with new NGS research panel from Thermo Fisher Scientific, suggest coronavirus is genetically stable, and could increase the effectiveness of vaccines in development</p> </div> </div> <div class="cmp-tfc-separator"> <div id="separator-27a7eaf31a" class="cmp-separator"> <hr class="cmp-separator__horizontal-rule"/> </div> </div> <div class="cmp-tfc-separator pt-l1 m--spacing"> <div id="separator-7863c8e7f5" class="cmp-separator"> <hr class="cmp-separator__horizontal-rule"/> </div> </div> <div class="cmp-tfc-container"> <div id="container-5214b504a0" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-tfc-text aem-GridColumn aem-GridColumn--default--12"> <div id="text-1257007495" class="cmp-text"> <p>CARLSBAD, Calif.,聽March 25, 2020聽/<a href="http://www.prnewswire.com/" target="_blank">PRNewswire</a>/ --聽Two teams of infectious disease researchers in聽Italy聽say they have further analyzed the SARS-CoV-2 genome from samples acquired locally to generate early data that reveal a level of genetic variability suggesting the rapidly spreading virus's genome is stable. The findings, developed using a new next-generation sequencing (NGS) research assay from聽<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=2760093-1&amp;h=1004700273&amp;u=https%3A%2F%2Fwww.thermofisher.com%2Fus%2Fen%2Fhome.html&amp;a=Thermo+Fisher+Scientific" target="_blank">Thermo Fisher Scientific</a>, increase the likelihood that future coronavirus vaccines can have a higher rate of effectiveness and could help the global scientific community's effort to better understand the epidemiology and spread of COVID-19.</p> <p>聽</p> <p>The two independent research teams from &quot;Lazzaro Spallanzani&quot; National Institute for Infectious Diseases (IRCCS) in聽Rome聽and the Forensic Division of the Department of Biomedical Sciences and Public Health (DSBSP) at Ancona University Hospital sequenced multiple samples and identified the presence of gene variants when compared against the original聽Wuhan聽coronavirus reference genome. Viruses that mutate rapidly over short periods of time make it challenging to develop effective vaccines that protect people against infection. The low number of variants discovered in the Italian samples two months after the virus was first sequenced in聽China聽suggests that SARS-CoV-2, which has infected more than an estimated 64,000 people in聽Italy聽and 380,000 globally, is a relatively slow-mutating pathogen. Both teams in聽Italy聽carried out the sequencing work with聽Thermo Fisher's聽new聽<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=2760093-1&amp;h=4203209827&amp;u=https%3A%2F%2Fwww.thermofisher.com%2Fus%2Fen%2Fhome%2Flife-science%2Fsequencing%2Fdna-sequencing%2Fmicrobial-sequencing%2Fmicrobial-identification-ion-torrent-next-generation-sequencing%2Fviral-typing%2Fcoronavirus-research.html%3Ficid%3DWB44102&amp;a=Ion+AmpliSeq+SARS-COV-2+Research+Panel" target="_blank">Ion AmpliSeq SARS-COV-2 Research Panel</a>, which features a 24-hour, end-to-end workflow.</p> <p>聽</p> <p>&quot;The ability to very quickly run multiple samples and accurately decipher key changes in the virus's genetic code will be crucial for the global scientific community to stay ahead of SARS-CoV-2 and to develop strategies against it that, ultimately, can be leveraged to help resolve the pandemic,&quot; said Dr.聽Maria Rosaria Capobianchi, head of the Virology Department, Lazzaro Spallanzani National Institute for Infectious Diseases, which was the first research center in聽Europe聽to generated whole genome sequencing data of the coronavirus on聽Thermo Fisher's聽Ion Torrent NGS platform. &quot;Viral genomes are dynamic and these preliminary data need further analysis to determine the biological significance of the gene variants and to investigate the evolutionary path of the coronavirus.&quot;</p> <p>聽</p> <p>Professor聽Stefano Menzo, head of Virology at Ancona University Hospital, said: &quot;Had we investigated other viruses we might have expected up to dozens of new mutations after so many infectious cycles in patients. Our initial data show that this is a very stable RNA virus, with only five novel variants. A virus with a stable genome is good news for vaccine development because it indicates that the effectiveness of vaccines could be more consistent, possibly over many years.&quot;</p> <p>聽</p> <p>The scientists now plan to further analyze the data with聽Thermo Fisher's聽new Ion SARS-CoV-2 analysis solution* for variant annotation and consensus sequencing assembly to better understand the impact on disease severity, mode of transmission, and phylogenetic studies. The Ion AmpliSeq SARS-COV-2 Research Panel is a targeted NGS solution that analyzes the entire SARS-CoV-2 genome. It provides an efficient, high-throughput end-to-end workflow for monitoring genomic evolution, which is critical during a rapidly developing pandemic. The panel is optimized to run on the聽<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=2760093-1&amp;h=131914313&amp;u=https%3A%2F%2Fwww.thermofisher.com%2Fus%2Fen%2Fhome%2Flife-science%2Fsequencing%2Fnext-generation-sequencing%2Fion-torrent-next-generation-sequencing-workflow%2Fion-torrent-next-generation-sequencing-run-sequence%2Fion-s5-ngs-targeted-sequencing.html&amp;a=Ion+GeneStudio+S5+System" target="_blank">Ion GeneStudio S5 System</a>s.*</p> <p>聽</p> <h2>Panel Optimization for Genexus System Underway</h2> <p><b><br /> </b>To further expedite NGS analysis of SARS-CoV-2 and to help meet growing customer demand,聽Thermo Fisher聽has begun to optimize the Ion AmpliSeq SARS-COV-2 Research Panel for the聽<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=2760093-1&amp;h=3875417891&amp;u=https%3A%2F%2Fwww.thermofisher.com%2Fus%2Fen%2Fhome%2Fproducts-and-services%2Fpromotions%2Flife-science%2Fion-torrent-genexus-system.html&amp;a=Ion+Torrent+Genexus+System" target="_blank">Ion Torrent Genexus System</a>.*聽<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=2760093-1&amp;h=3290122420&amp;u=https%3A%2F%2Fwww.prnewswire.com%2Fnews-releases%2Fthermo-fisher-scientific-introduces-first-next-generation-sequencing-platform-that-delivers-specimen-to-report-in-a-single-day-300951867.html&amp;a=Launched+in+November+2019" target="_blank">Launched in聽November 2019</a>, the company's newest sequencing platform automates the entire targeted NGS workflow and can deliver specimen to report economically in as little as 14 hours. Optimization and validation of the research panel on the Genexus System is now underway in collaboration with聽Thermo Fisher聽customers.</p> <p>聽</p> <p>&quot;Thermo Fisher's聽immediate response to first develop a PCR SARS-CoV-2 diagnostic** assay and now a next-generation sequencing research solution to help customers investigate coronavirus is at the core of our mission,&quot; said聽Peter Silvester, senior vice president and president of Life Sciences Solutions at Thermo Fisher Scientific. &quot;We share the global community's heightened concern during this unprecedented public health crisis and, for this reason, we are continuing to maximize our efforts to provide our laboratory partners, infectious disease researchers and vaccine developers with the most advanced tools in support of their very important work.&quot;</p> <p>聽</p> <h2>About Thermo Fisher Scientific<br /> </h2> <p>Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding聽$30 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them. Our global team of more than 80,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit聽<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=3118031-1&amp;h=1627364097&amp;u=http%3A%2F%2Fwww.thermofisher.com%2F&amp;a=www.thermofisher.com" target="_blank">www.thermofisher.com</a>.</p> <p>聽</p> <p>* For Research Use Only.聽 Not for use in diagnostic procedures.</p> <p>** Designation as an IVD or as an IVD for emergency use / special access varies from region to region.</p> <p>聽</p> </div> </div> <div class="cmp-tfc-container aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--offset--default--0"> <div id="container-9644128306" class="cmp-container"> <div class="cmp-tfc-text"> <div id="text-1515308807" class="cmp-text"> <p>Mauricio Minotta<br /> Thermo Fisher Scientific<br /> +1 760 929 2456<br /> +1 760 805-5266 (mobile)<br /> <a href="mailto:Mauricio.minotta@thermofisher.com">Mauricio.minotta@thermofisher.com</a></p> <p>聽</p> <p>Jen Heady<br /> Greenough Communications<br /> +1 617 275 6547<br /> <a href="mailto:jheady@greenough.biz">jheady@greenough.biz</a></p> </div> </div> </div> </div> <div class="cmp-tfc-text aem-GridColumn aem-GridColumn--default--12"> <div id="text-1266647412" class="cmp-text"> <p>聽</p> <p>SOURCE Thermo Fisher Scientific</p> <p>聽</p> <p>If you have any questions regarding this Press Release, please email us at聽<a href="mailto:media.relations@thermofisher.com?Subject=Press%20release">media.relations@thermofisher.com</a>.</p> </div> </div> <div class="cmp-tfc-separator pt-l3 m--spacing aem-GridColumn aem-GridColumn--default--12"> <div id="separator-df40936a8a" class="cmp-separator"> <hr class="cmp-separator__horizontal-rule"/> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cmp-tfc-experiencefragment"><div id="footer" class="cmp-experiencefragment cmp-experiencefragment--footer"> <div id="container-cad5af0891" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-tfc-container aem-GridColumn aem-GridColumn--default--12"> <div id="scroll-section" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-tfc-container aem-GridColumn--offset--default--10 aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--2"> <div id="go-up-container" class="cmp-container"> <div class="aem-Grid aem-Grid--2 aem-Grid--default--2 "> <div class="cmp-tfc-text aem-GridColumn--default--none aem-GridColumn aem-GridColumn--offset--default--0 aem-GridColumn--default--1"> <div id="text-899537299" class="cmp-text"> <p>Back to top</p> </div> </div> <div class="cmp-tfc-button aem-GridColumn--default--none aem-GridColumn aem-GridColumn--offset--default--0 aem-GridColumn--default--1"> <button type="button" id="scroll-up" class="cmp-button"> <span class="cmp-button__icon cmp-button__icon--burger" aria-hidden="true"></span> <span class="cmp-button__text">Go Up</span> </button> </div> </div> </div> </div> </div> </div> </div> <div class="cmp-tfc-container aem-GridColumn aem-GridColumn--default--12"> <div id="lighter-footer" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-tfc-text aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="about-footer" class="cmp-text"> <p><b>About Thermo Fisher Scientific</b></p> <p>Thermo Fisher Scientific Inc. 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