Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress

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Nonclinical data supporting the tolerability of deep and sustained HTT-lowering in wild-type nonhuman primates after single..." /> <meta property="og:url" content="https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024" /> <meta property="og:site_name" content="Alnylam" /> <meta property="article:published_time" content="2024-09-13T12:50:43+00:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Written by" /> <meta name="twitter:data1" content="Chris Brickley" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebSite","@id":"https://capella.alnylam.com/#website","url":"https://capella.alnylam.com/","name":"Alnylam","description":"Home","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://capella.alnylam.com/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024#webpage","url":"https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024","name":"Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress - Alnylam","isPartOf":{"@id":"https://capella.alnylam.com/#website"},"datePublished":"2024-09-13T12:50:43+00:00","dateModified":"2024-09-13T12:50:43+00:00","author":{"@id":"https://capella.alnylam.com/#/schema/person/d0ae6a140361feb7e09d1db2b5e4a8b3"},"breadcrumb":{"@id":"https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024"]}]},{"@type":"BreadcrumbList","@id":"https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://capella.alnylam.com/"},{"@type":"ListItem","position":2,"name":"Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress"}]},{"@type":"Person","@id":"https://capella.alnylam.com/#/schema/person/d0ae6a140361feb7e09d1db2b5e4a8b3","name":"Chris Brickley","image":{"@type":"ImageObject","@id":"https://capella.alnylam.com/#personlogo","inLanguage":"en-US","url":"https://secure.gravatar.com/avatar/53efd17f54cd427bfe492c2ffd0ba34b?s=96&d=mm&r=g","contentUrl":"https://secure.gravatar.com/avatar/53efd17f54cd427bfe492c2ffd0ba34b?s=96&d=mm&r=g","caption":"Chris Brickley"}}]}</script>  <link rel='dns-prefetch' href='//capella.alnylam.com' /> <link rel='dns-prefetch' href='//maps.googleapis.com' /> <link rel='dns-prefetch' href='//fonts.googleapis.com' /> <link rel="alternate" type="application/rss+xml" title="Alnylam » Feed" href="https://capella.alnylam.com/feed" /> <link rel="alternate" type="application/rss+xml" title="Alnylam » Comments Feed" href="https://capella.alnylam.com/comments/feed" /> <link rel="alternate" type="application/rss+xml" title="Alnylam » Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress Comments Feed" href="https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024/feed" /> <script type="text/javascript"> window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/14.0.0\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/14.0.0\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/capella.alnylam.com\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.3.1"}}; /*! 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Click the help icon above to learn more. */ .pp_details { position: absolute !important; top: -10px; height: 0; display: block !important; } .pp_social, .pp_nav, .pp_description { display: none !important; } .theme-22242 .pum-close, .theme-22242 .popmake-close, .theme-22242 .pum-close:focus, .theme-22242 .popmake-close:focus, .theme-22242 .pum-close:active, .theme-22242 .popmake-close:active { background-image: none !important; } header div #searchform {top: -100px; position: absolute; } body.postid-23283 #elastic-search { display: none; } .content { margin-top: 0; } .main_menu { height: 20px; } .header_menu_bottom .main_menu { text-align: left; } </style> <noscript><style type="text/css"> .wpb_animate_when_almost_visible { opacity: 1; }</style></noscript><style type="text/css">/** Tuesday 30th July 2024 17:14:48 UTC (core) **//** THIS FILE IS AUTOMATICALLY GENERATED - DO NOT MAKE MANUAL EDITS! **//** Custom CSS should be added to Mega Menu > Menu Themes > Custom Styling 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none;opacity: 1;outline: none;overflow: visible;padding: 0;position: relative;pointer-events: auto;right: auto;text-align: left;text-decoration: none;text-indent: 0;text-transform: none;transform: none;top: auto;vertical-align: baseline;visibility: inherit;width: auto;word-wrap: break-word;white-space: normal;}#mega-menu-wrap-max_mega_menu_1:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 span.mega-menu-badge:before, #mega-menu-wrap-max_mega_menu_1:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 span.mega-menu-badge:after {display: none;}#mega-menu-wrap-max_mega_menu_1 {border-radius: 0;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 {background: #222;}}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-menu-toggle:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block a:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block .mega-search input[type=text]:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block button.mega-toggle-animated:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 a:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 input:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 li.mega-menu-item a.mega-menu-link:focus {outline: 3px solid #109cde;outline-offset: -3px;}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block button.mega-toggle-animated:focus {outline-offset: 2px;}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation > li.mega-menu-item > a.mega-menu-link:focus {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation > li.mega-menu-item > a.mega-menu-link:focus {color: #fff;background: #333;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 {visibility: visible;text-align: left;padding: 0px 0px 0px 0px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link {cursor: pointer;display: inline;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group {vertical-align: middle;display: inline-block;transition: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group .mega-menu-title, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group .mega-menu-description {transition: none;line-height: 1.5;display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group .mega-menu-description {font-style: italic;font-size: 0.8em;text-transform: none;font-weight: normal;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link {display: flex;align-items: center;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link:before {flex: 0 0 auto;align-self: flex-start;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-tabbed.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link {display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-top > a.mega-menu-link {display: table-cell;vertical-align: middle;line-height: initial;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-top > a.mega-menu-link:before {display: block;margin: 0 0 6px 0;text-align: center;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-top > a.mega-menu-link > span.mega-title-below {display: inline-block;transition: none;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-icon-top > a.mega-menu-link {display: block;line-height: 40px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-icon-top > a.mega-menu-link:before {display: inline-block;margin: 0 6px 0 0;text-align: left;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-right > a.mega-menu-link:before {float: right;margin: 0 0 0 6px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-animating > ul.mega-sub-menu {pointer-events: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-disable-link > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu li.mega-disable-link > a.mega-menu-link {cursor: inherit;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-disable-link > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > li.mega-menu-item-has-children.mega-disable-link > a.mega-menu-link {cursor: pointer;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 p {margin-bottom: 10px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 input, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 img {max-width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item > ul.mega-sub-menu {display: block;visibility: hidden;opacity: 1;pointer-events: auto;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item > ul.mega-sub-menu {display: none;visibility: visible;opacity: 1;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu.mega-menu-item.mega-toggle-on ul.mega-sub-menu {display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu.mega-menu-item.mega-toggle-on li.mega-hide-sub-menu-on-mobile > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-sub-menu-on-mobile > ul.mega-sub-menu {display: none;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"] li.mega-menu-item > ul.mega-sub-menu {opacity: 0;transition: opacity 200ms ease-in, visibility 200ms ease-in;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"].mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"].mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"] li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu {opacity: 1;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-menu-megamenu > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu {opacity: 0;transform: translate(0, 10px);transition: opacity 200ms ease-in, transform 200ms ease-in, visibility 200ms ease-in;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"].mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"].mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu {opacity: 1;transform: translate(0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-menu-megamenu > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu {transform: translate(0, 10px);transition: transform 200ms ease-in, visibility 200ms ease-in;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"].mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"].mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu {transform: translate(0, 0);}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-collapse-children > ul.mega-sub-menu {display: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-collapse-children.mega-toggle-on > ul.mega-sub-menu {display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu {visibility: visible;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu ul.mega-sub-menu {visibility: inherit;opacity: 1;display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-1-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-2-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-3-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-4-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-5-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-6-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item a[class^='dashicons']:before {font-family: dashicons;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item a.mega-menu-link:before {display: inline-block;font: inherit;font-family: dashicons;position: static;margin: 0 6px 0 0px;vertical-align: top;-webkit-font-smoothing: antialiased;-moz-osx-font-smoothing: grayscale;color: inherit;background: transparent;height: auto;width: auto;top: auto;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-hide-text a.mega-menu-link:before {margin: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-hide-text li.mega-menu-item a.mega-menu-link:before {margin: 0 6px 0 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-left.mega-toggle-on > a.mega-menu-link {border-radius: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-right > ul.mega-sub-menu {right: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-right.mega-toggle-on > a.mega-menu-link {border-radius: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-menu-item {position: static;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item {margin: 0 0px 0 0;display: inline-block;height: auto;vertical-align: middle;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-right {float: right;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-right {margin: 0 0 0 0px;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-float-left {float: left;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item > a.mega-menu-link:hover {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-toggle-on > a.mega-menu-link {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-toggle-on > a.mega-menu-link {color: #fff;background: #333;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-ancestor > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-page-ancestor > a.mega-menu-link {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-ancestor > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-page-ancestor > a.mega-menu-link {color: #fff;background: #333;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item > a.mega-menu-link {line-height: 40px;height: 40px;padding: 0px 10px 0px 10px;vertical-align: baseline;width: auto;display: block;color: #fff;text-transform: none;text-decoration: none;text-align: left;text-decoration: none;background: rgba(0, 0, 0, 0);border: 0;border-radius: 0;font-family: inherit;font-size: 14px;font-weight: normal;outline: none;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-multi-line > a.mega-menu-link {line-height: inherit;display: table-cell;vertical-align: middle;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-multi-line > a.mega-menu-link br {display: none;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item {display: list-item;margin: 0;clear: both;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-right {float: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item > a.mega-menu-link {border-radius: 0;border: 0;margin: 0;line-height: 40px;height: 40px;padding: 0 10px;background: transparent;text-align: left;color: #fff;font-size: 14px;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row {width: 100%;float: left;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row .mega-menu-column {float: left;min-height: 1px;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-1 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-2 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-2 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-3 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-3 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-3 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-4 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-4 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-4 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-4 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-5 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-5 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-5 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-5 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-5 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-6 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-6 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-6 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-6 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-6 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-6 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-7 {width: 14.28571%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-7 {width: 28.57143%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-7 {width: 42.85714%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-7 {width: 57.14286%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-7 {width: 71.42857%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-7 {width: 85.71429%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-7 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-8 {width: 12.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-8 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-8 {width: 37.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-8 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-8 {width: 62.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-8 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-8 {width: 87.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-8 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-9 {width: 11.11111%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-9 {width: 22.22222%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-9 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-9 {width: 44.44444%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-9 {width: 55.55556%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-9 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-9 {width: 77.77778%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-9 {width: 88.88889%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-9 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-10 {width: 10%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-10 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-10 {width: 30%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-10 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-10 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-10 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-10 {width: 70%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-10 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-10 {width: 90%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-10-of-10 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-11 {width: 9.09091%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-11 {width: 18.18182%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-11 {width: 27.27273%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-11 {width: 36.36364%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-11 {width: 45.45455%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-11 {width: 54.54545%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-11 {width: 63.63636%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-11 {width: 72.72727%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-11 {width: 81.81818%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-10-of-11 {width: 90.90909%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-11-of-11 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-12 {width: 8.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-12 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-12 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-12 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-12 {width: 41.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-12 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-12 {width: 58.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-12 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-12 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-10-of-12 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-11-of-12 {width: 91.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-12-of-12 {width: 100%;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-column {width: 100%;clear: both;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row .mega-menu-column > ul.mega-sub-menu > li.mega-menu-item {padding: 15px 15px 15px 15px;width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu {z-index: 999;border-radius: 0;background: #f1f1f1;border: 0;padding: 0px 0px 0px 0px;position: absolute;width: 100%;max-width: none;left: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu {float: left;position: static;width: 100%;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-1 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-2 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-2 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-3 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-3 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-3 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-4 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-4 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-4 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-4 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-5 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-5 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-5 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-5 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-5 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-6 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-6 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-6 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-6 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-6 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-6 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-7 {width: 14.28571%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-7 {width: 28.57143%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-7 {width: 42.85714%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-7 {width: 57.14286%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-7 {width: 71.42857%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-7 {width: 85.71429%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-7 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-8 {width: 12.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-8 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-8 {width: 37.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-8 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-8 {width: 62.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-8 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-8 {width: 87.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-8 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-9 {width: 11.11111%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-9 {width: 22.22222%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-9 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-9 {width: 44.44444%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-9 {width: 55.55556%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-9 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-9 {width: 77.77778%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-9 {width: 88.88889%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-9 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-10 {width: 10%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-10 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-10 {width: 30%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-10 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-10 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-10 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-10 {width: 70%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-10 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-10 {width: 90%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-10-of-10 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-11 {width: 9.09091%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-11 {width: 18.18182%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-11 {width: 27.27273%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-11 {width: 36.36364%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-11 {width: 45.45455%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-11 {width: 54.54545%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-11 {width: 63.63636%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-11 {width: 72.72727%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-11 {width: 81.81818%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-10-of-11 {width: 90.90909%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-11-of-11 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-12 {width: 8.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-12 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-12 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-12 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-12 {width: 41.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-12 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-12 {width: 58.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-12 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-12 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-10-of-12 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-11-of-12 {width: 91.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-12-of-12 {width: 100%;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu .mega-description-group .mega-menu-description {margin: 5px 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item ul.mega-sub-menu {clear: both;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {margin-left: 10px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu ul.mega-sub-menu ul.mega-sub-menu {margin-left: 10px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item {color: #666;font-family: inherit;font-size: 14px;display: block;float: left;clear: none;padding: 15px 15px 15px 15px;vertical-align: top;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item.mega-menu-clear, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item.mega-menu-clear {clear: left;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title {color: #555;font-family: inherit;font-size: 16px;text-transform: uppercase;text-decoration: none;font-weight: bold;text-align: left;margin: 0px 0px 0px 0px;padding: 0px 0px 5px 0px;vertical-align: top;display: block;visibility: inherit;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title:hover {border-color: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link {/* Mega Menu > Menu Themes > Mega Menus > Second Level Menu Items */color: #555;font-family: inherit;font-size: 16px;text-transform: uppercase;text-decoration: none;font-weight: bold;text-align: left;margin: 0px 0px 0px 0px;padding: 0px 0px 0px 0px;vertical-align: top;display: block;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover {border-color: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus {/* Mega Menu > Menu Themes > Mega Menus > Second Level Menu Items (Hover) */color: #555;font-weight: bold;text-decoration: none;background: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover > span.mega-title-below, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover > span.mega-title-below, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus > span.mega-title-below, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus > span.mega-title-below {text-decoration: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link {/* Mega Menu > Menu Themes > Mega Menus > Third Level Menu Items */color: #666;font-family: inherit;font-size: 14px;text-transform: none;text-decoration: none;font-weight: normal;text-align: left;margin: 0px 0px 0px 0px;padding: 0px 0px 0px 0px;vertical-align: top;display: block;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover {border-color: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link {display: flex;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:focus, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:focus {/* Mega Menu > Menu Themes > Mega Menus > Third Level Menu Items (Hover) */color: #666;font-weight: normal;text-decoration: none;background: rgba(0, 0, 0, 0);}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu {border: 0;padding: 10px;border-radius: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item {width: 100%;clear: both;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link {color: #666;font-family: inherit;font-size: 14px;text-transform: none;text-decoration: none;font-weight: normal;margin: 0;border: 0;padding: 0px 0px 0px 0px;vertical-align: top;display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus {color: #666;font-weight: normal;text-decoration: none;background: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu {z-index: 999;position: absolute;width: 250px;max-width: none;padding: 0px 0px 0px 0px;border: 0;background: #f1f1f1;border-radius: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu {float: left;position: static;width: 100%;padding: 0;border: 0;border-radius: 0;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item {clear: both;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link {display: block;background: #f1f1f1;color: #666;font-family: inherit;font-size: 14px;font-weight: normal;padding: 0px 10px 0px 10px;line-height: 35px;text-decoration: none;text-transform: none;vertical-align: baseline;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:first-child > a.mega-menu-link {border-top-left-radius: 0px;border-top-right-radius: 0px;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:first-child > a.mega-menu-link {border-top-left-radius: 0;border-top-right-radius: 0;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:last-child > a.mega-menu-link {border-bottom-right-radius: 0px;border-bottom-left-radius: 0px;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:last-child > a.mega-menu-link {border-bottom-right-radius: 0;border-bottom-left-radius: 0;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link:focus {background: #ddd;font-weight: normal;text-decoration: none;color: #666;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {position: absolute;left: 100%;top: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {position: static;left: 0;width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu a.mega-menu-link {padding-left: 20px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu ul.mega-sub-menu a.mega-menu-link {padding-left: 30px;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator:after {content: '\f140';font-family: dashicons;font-weight: normal;display: inline-block;margin: 0 0 0 6px;vertical-align: top;-webkit-font-smoothing: antialiased;-moz-osx-font-smoothing: grayscale;transform: rotate(0);color: inherit;position: relative;background: transparent;height: auto;width: auto;right: auto;line-height: inherit;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {display: inline;height: auto;width: auto;background: transparent;position: relative;pointer-events: auto;left: auto;min-width: auto;line-height: inherit;color: inherit;font-size: inherit;padding: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {float: right;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-collapse-children.mega-toggle-on > a.mega-menu-link > span.mega-indicator:after {content: '\f142';}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {float: right;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-toggle-on > a.mega-menu-link > span.mega-indicator:after {content: '\f142';}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-hide-sub-menu-on-mobile > a.mega-menu-link > span.mega-indicator {display: none;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu:not(.mega-menu-tabbed) li.mega-menu-item-has-children:not(.mega-collapse-children) > a.mega-menu-link > span.mega-indicator, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-hide-arrow > a.mega-menu-link > span.mega-indicator {display: none;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout li.mega-menu-item a.mega-menu-link > span.mega-indicator:after {content: '\f139';}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link {text-align: right;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link > span.mega-indicator {float: left;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link > span.mega-indicator:after {content: '\f141';margin: 0 6px 0 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link:before {float: right;margin: 0 0 0 6px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {left: -100%;top: 0;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-menu-accordion > li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {float: right;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li[class^='mega-lang-item'] > a.mega-menu-link > img {display: inline;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link > img.wpml-ls-flag, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link > img.iclflag {display: inline;margin-right: 8px;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-on-mobile, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-hide-on-mobile, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item.mega-hide-on-mobile {display: none;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-on-desktop, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-hide-on-desktop, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item.mega-hide-on-desktop {display: none;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1:after {content: "";display: table;clear: both;}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle {display: none;z-index: 1;cursor: pointer;background: #222;border-radius: 2px 2px 2px 2px;line-height: 40px;height: 40px;text-align: left;user-select: none;-webkit-tap-highlight-color: transparent;outline: none;white-space: nowrap;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle img {max-width: 100%;padding: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle {display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right {display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;-ms-flex-preferred-size: 33.33%;-webkit-flex-basis: 33.33%;flex-basis: 33.33%;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left {-webkit-box-flex: 1;-ms-flex: 1;-webkit-flex: 1;flex: 1;-webkit-box-pack: start;-ms-flex-pack: start;-webkit-justify-content: flex-start;justify-content: flex-start;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left .mega-toggle-block {margin-left: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left .mega-toggle-block:only-child {margin-right: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center {-webkit-box-pack: center;-ms-flex-pack: center;-webkit-justify-content: center;justify-content: center;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center .mega-toggle-block {margin-left: 3px;margin-right: 3px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right {-webkit-box-flex: 1;-ms-flex: 1;-webkit-flex: 1;flex: 1;-webkit-box-pack: end;-ms-flex-pack: end;-webkit-justify-content: flex-end;justify-content: flex-end;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right .mega-toggle-block {margin-right: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right .mega-toggle-block:only-child {margin-left: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block {display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;height: 100%;outline: 0;-webkit-align-self: center;-ms-flex-item-align: center;align-self: center;-ms-flex-negative: 0;-webkit-flex-shrink: 0;flex-shrink: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle + #mega-menu-max_mega_menu_1 {background: #222;padding: 0px 0px 0px 0px;display: none;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open + #mega-menu-max_mega_menu_1 {display: block;}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle {/** Push menu onto new line **/}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 {/*! * Hamburgers * @description Tasty CSS-animated hamburgers * @author Jonathan Suh @jonsuh * @site https://jonsuh.com/hamburgers * @link https://github.com/jonsuh/hamburgers */cursor: pointer;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated {padding: 0;display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;cursor: pointer;transition-property: opacity, filter;transition-duration: 0.15s;transition-timing-function: linear;font: inherit;color: inherit;text-transform: none;background-color: transparent;border: 0;margin: 0;overflow: visible;transform: scale(0.8);align-self: center;outline: 0;background: none;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-box {width: 40px;height: 24px;display: inline-block;position: relative;outline: 0;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner {display: block;top: 50%;margin-top: -2px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::before, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::after {width: 40px;height: 4px;background-color: #797979;border-radius: 4px;position: absolute;transition-property: transform;transition-duration: 0.15s;transition-timing-function: ease;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::before, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::after {content: "";display: block;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::before {top: -10px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::after {bottom: -10px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner {top: 2px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::before {top: 10px;transition-property: transform, opacity;transition-timing-function: ease;transition-duration: 0.15s;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::after {top: 20px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner {transform: translate3d(0, 10px, 0) rotate(45deg);}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::before {transform: rotate(-45deg) translate3d(-5.71429px, -6px, 0);opacity: 0;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::after {transform: translate3d(0, -20px, 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Nederlands</a > </div> <div class="field--item"> <a href="https://www.alnylam.com/alnylam-belgium-french" >Français</a > </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--112 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Brazil </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com.br/">Português</a> </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--114 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> <p></p> </div> <p></p></span></div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1513 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Czech Republic </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com/alnylam-czech-republic" >Čeština</a > </div> 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</span> </a> <div class="content "> <div class="content_inner "> <div class="title_outer title_without_animation" data-height="217"> <div class="title title_size_small position_left " style="height:217px;background-color:#F6F6F6;"> <div class="image not_responsive"></div> <div class="title_holder" style="padding-top:117px;height:100px;"> <div class="container"> <div class="container_inner clearfix"> <div class="title_subtitle_holder" > <h1 ><span>Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress</span></h1> </div> </div> </div> </div> </div> </div> <div class="container"> <div class="container_inner default_template_holder" > <div class="blog_single blog_holder"> <article id="post-26525" class="post-26525 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder"> <div class="post_image"> <img width="520" height="180" class="attachment-full size-full wp-post-image" src="/wp-content/uploads/2017/04/default_blog_image.jpg" /> </div> <div class="post_text"> <div class="post_text_inner"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">13 Sep, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress</h2> <div class="post_info"> <span class="time">Posted at 08:50h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> <span class="post_author"> by <a itemprop="author" class="post_author_link" href="https://capella.alnylam.com/author/cbrickley">Chris Brickley</a> </span> </div> <p>The design of a Phase 1 study of ALN-HTT02—an investigational RNAi therapeutic targeting huntingtin (HTT) for Huntington’s disease—was presented at the EHDN & Enroll-HD 2024 Congress in Strasbourg, France. Nonclinical data supporting the tolerability of deep and sustained HTT-lowering in wild-type nonhuman primates after single and repeated intrathecal administration of ALN-HTT02—which employs Alnylam’s C16-siRNA CNS delivery platform—were also shared.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Sloan_ALN-HTT02-Program-Overview_EHDN-Presentation_FINAL.pdf" target="_blank" rel="noopener">Sloan, <em>et al</em>. “ALN-HTT02, a Novel C16-siRNA Conjugate for HTT-lowering in the CNS”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/2024-EHDN-Poster-HTT_WLC_final.pdf" target="_blank" rel="noopener">Cantley, <em>et al</em>. “Tolerability of HTT-Lowering: Lessons Learned from Nonhuman Primates”</a></p> </div> </div> </div> </article> <br/><br/> </div> </div> </div> <div class="content_bottom" > <div class="widget widget_text"> <div class="textwidget"><section class="new-footer"> <div class="top-dna-lines"> <div class="footer-dna-lines"> <div class="footer-container"> <div class="d-flex"> <div> <h2 class="footer-header">FOLLOW US</h2> <p class="footer-description">Visit our social channels to learn more about the innovative work we are doing at Alnylam.</p> </div> <div class="right-icons d-flex"> <a target="_blank" href="https://www.youtube.com/channel/UCUZReY0GSAJ1w-MULQb9_Rw" rel="noopener"> <img loading="eager" src="/wp-content/uploads/img/youtube_icon.svg" /> </a> <a target="_blank" href="https://www.facebook.com/AlnylamPharma/" rel="noopener"> <img loading="eager" src="/wp-content/uploads/img/fb_icon.svg" /> </a> <a target="_blank" href="https://twitter.com/alnylam" rel="noopener"> <img loading="eager" src="/wp-content/uploads/img/x_icon.svg" /> </a> <a target="_blank" href="https://www.linkedin.com/company/alnylam-pharmaceuticals/" rel="noopener"> <img loading="eager" src="/wp-content/uploads/img/linkedin_icon.svg" /> </a> <a target="_blank" href="https://www.instagram.com/alnylampharma/" rel="noopener"> <img loading="eager" src="/wp-content/uploads/img/instagram_icon.svg" /> </a> </div> </div> </div> </div> </div> </section></div> </div> </div> </div> </div> <footer > <div class="footer_inner clearfix"> <div class="footer_top_holder"> <div class="footer_top"> <div class="container"> <div class="container_inner"> <div class="four_columns clearfix"> <div class="col"> <div id="footer_one"> <div class="textwidget"><h2><a href="https://www.alnylam.com/about-alnylam/">Our Company</a></h2> <h2><a href="https://www.alnylam.com/our-science/the-science-of-rnai">Our Science</a></h2> <h2><a href="https://www.alnylam.com/our-products">Our Products</a></h2> <h2><a href="https://news.alnylam.com/">Our News</a></h2> </div> </div> </div> <div class="col"> <div id="footer_second"> <div class="textwidget"><h2><a href="https://investors.alnylam.com/">Investors</a></h2> <h2><a href="https://www.alnylam.com/medical-professional-resources/">Medical Professionals</a></h2> <h2><a href="https://www.alnylam.com/patients/">Patients</a></h2> <h2><a href="https://www.alnylam.com/careers/">Job Seekers</a></h2></div> </div> </div> <div class="col"> <div id="footer_third"> <div class="textwidget"><h2><a href="https://www.alnylam.com/alnylam-rnai-pipeline/clinical-trials/">Clinical Trials</a></h2> <h2><a href="https://www.alnylam.com/about-alnylam/corporate-responsibility/">Corporate Responsibility</a></h2> <h2><a href="https://www.alnylam.com/about-alnylam/diversity-inclusion/">Diversity, Equity & Inclusion</a></h2> <h2><a href="https://investors.alnylam.com/press-releases/">Press Releases</a></h2> <h2><a href="/our-science/capella-rnai-innovation/">Capella</a></h2> <h2><a target="_blank" href="https://www.rnaiscience.com/" rel="noopener">Medical Resources (RNAi Science)</a></h2> <h2><a href="https://www.alnylam.com/contact-us/">Contact Us</a></h2> <h2><a href="https://www.alnylam.com/signup-for-updates/">Sign Up For Updates</a></h2></div> </div> </div> <div class="col"> <div id="footer_fourth"> <div class="textwidget"><div class="links-left"><h2><a href="https://alnylampolicies.com/privacy">Privacy Policy</a></h2> <h2 class="ipad-mobile-hide"><a href="https://www.alnylam.com/media-kit">Media Kit</a></h2> <h2><a href="https://alnylampolicies.com/legal">Legal Notice</a></h2> </div> <div class="links-right"> <h2><a href="https://www.alnylam.com/sitemap/">Site Map</a></h2> <h2 class="show-tab"><a href="https://www.alnylam.com/signup-for-updates">Sign Up For Updates</a></h2> </div></div> </div> </div> <div class="col"> </div> <div class="col"> </div> <div class="col"> </div> </div> </div> </div> </div> </div> <div class="footer_bottom_holder"> <div class="footer_bottom"> <div class="textwidget"><div class="container_inner"> <div class="top_wrapper_links"> <span class="copyright">Copyright © <span class="timer"> </span> Alnylam Pharmaceuticals, Inc. — All Rights Reserved</span></div> <div class="clearfix_footer"></div> </div> <script> var currentYear = new Date().getFullYear(); 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