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class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42358348" href="https://www.academia.edu/Documents/in/Bioinformatics"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/Fatai","location":"/Fatai","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/Fatai","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Bioinformatics"]}" data-trace="false" data-dom-id="Pill-react-component-97a3a397-8cd3-4652-a214-1d27c0b83d57"></div> <div id="Pill-react-component-97a3a397-8cd3-4652-a214-1d27c0b83d57"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42358348" href="https://www.academia.edu/Documents/in/Molecular_Biology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Molecular Biology"]}" data-trace="false" data-dom-id="Pill-react-component-8e864122-9b88-437a-8a06-9f9f31ae22a0"></div> <div id="Pill-react-component-8e864122-9b88-437a-8a06-9f9f31ae22a0"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42358348" href="https://www.academia.edu/Documents/in/Biotechnology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biotechnology"]}" data-trace="false" data-dom-id="Pill-react-component-72c4553b-3155-4132-8a32-7f9c507511b6"></div> <div id="Pill-react-component-72c4553b-3155-4132-8a32-7f9c507511b6"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42358348" href="https://www.academia.edu/Documents/in/Chemistry"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Chemistry"]}" data-trace="false" data-dom-id="Pill-react-component-efe49203-08fe-458f-9767-74002b87dfdd"></div> <div id="Pill-react-component-efe49203-08fe-458f-9767-74002b87dfdd"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42358348" href="https://www.academia.edu/Documents/in/Biology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biology"]}" data-trace="false" data-dom-id="Pill-react-component-a054192f-242b-4e14-b6e0-fef7e22c09ac"></div> <div id="Pill-react-component-a054192f-242b-4e14-b6e0-fef7e22c09ac"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Azeez Fatai</h3></div><div class="js-work-strip profile--work_container" data-work-id="87416235"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416235/Additional_file_4_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer"><img alt="Research paper thumbnail of Additional file 4 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416235/Additional_file_4_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer">Additional file 4 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Unguided principal component analysis to assess batch effect. 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Samples in each batch are denoted by a different colour and symbol. 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(PDF 23.5 kb)","internal_url":"https://www.academia.edu/87416222/Additional_file_2_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_internal_url":"","created_at":"2022-09-27T06:13:41.355-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Additional_file_2_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":1083,"name":"Developmental Biology","url":"https://www.academia.edu/Documents/in/Developmental_Biology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":463461,"name":"Glioblastoma Multiforme","url":"https://www.academia.edu/Documents/in/Glioblastoma_Multiforme"},{"id":4011260,"name":"Risk groups","url":"https://www.academia.edu/Documents/in/Risk_groups"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87416213"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416213/Combined_Oral_Administration_of_Ethinylestradiol_and_Levonorgestrel_Alters_the_Expression_of_Antioxidant_and_Apoptotic_Markers_in_Female_Rats"><img alt="Research paper thumbnail of Combined Oral Administration of Ethinylestradiol and Levonorgestrel Alters the Expression of Antioxidant and Apoptotic Markers in Female Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/91629278/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416213/Combined_Oral_Administration_of_Ethinylestradiol_and_Levonorgestrel_Alters_the_Expression_of_Antioxidant_and_Apoptotic_Markers_in_Female_Rats">Combined Oral Administration of Ethinylestradiol and Levonorgestrel Alters the Expression of Antioxidant and Apoptotic Markers in Female Rats</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The use of ethinylestradiol and levonorgestrel (E/L) for birth control may result in serious adve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The use of ethinylestradiol and levonorgestrel (E/L) for birth control may result in serious adverse effects. Herein, the effect of (E/L) on the expression of genes encoding antioxidant enzymes (superoxide dismutase (SOD) and Catalase (CAT)), and apoptotic regulator genes (B-cell lymphoma 2 (BCL-2), caspase 1 and 3) was evaluated. Thirty-two rats were randomly divided into four equal groups. Group A (Control) received 0.5% DMSO, Group B, C and D received 0.015, 0.030, and 0.060 mg of E/L orally and daily for 21 days respectively. RNA extracted from brain, liver and kidney were purified, and the genes amplified using RT-PCR. Following analysis of the intensity of the amplicon bands on 1.2% agarose, the gene&#39;s relative expression compared with the expression 尾actin was determined. There was significant downregulation of SOD and CAT genes in the liver, brain and kidney in all groups treated with E/L compared to control. Caspase 1 and 3 expressions were significantly elevated by 3.8...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="12b6e9fd3ce47ac33d1a9b7ff9be92f5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91629278,"asset_id":87416213,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91629278/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87416213"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87416213"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87416213; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87416213]").text(description); $(".js-view-count[data-work-id=87416213]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87416213; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87416213']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87416213, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "12b6e9fd3ce47ac33d1a9b7ff9be92f5" } } $('.js-work-strip[data-work-id=87416213]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87416213,"title":"Combined Oral Administration of Ethinylestradiol and Levonorgestrel Alters the Expression of Antioxidant and Apoptotic Markers in Female Rats","translated_title":"","metadata":{"abstract":"The use of ethinylestradiol and levonorgestrel (E/L) for birth control may result in serious adverse effects. Herein, the effect of (E/L) on the expression of genes encoding antioxidant enzymes (superoxide dismutase (SOD) and Catalase (CAT)), and apoptotic regulator genes (B-cell lymphoma 2 (BCL-2), caspase 1 and 3) was evaluated. Thirty-two rats were randomly divided into four equal groups. Group A (Control) received 0.5% DMSO, Group B, C and D received 0.015, 0.030, and 0.060 mg of E/L orally and daily for 21 days respectively. RNA extracted from brain, liver and kidney were purified, and the genes amplified using RT-PCR. Following analysis of the intensity of the amplicon bands on 1.2% agarose, the gene\u0026#39;s relative expression compared with the expression 尾actin was determined. There was significant downregulation of SOD and CAT genes in the liver, brain and kidney in all groups treated with E/L compared to control. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87416207"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416207/Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_"><img alt="Research paper thumbnail of Characterization of Alkaline phosphatase (E.C.3.1.3.1) From Giant African Snail (Archachatina marginata)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416207/Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_">Characterization of Alkaline phosphatase (E.C.3.1.3.1) From Giant African Snail (Archachatina marginata)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The Km and Vmax were estimated to be 0.10 mM and 1.37 渭mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min.Metals (MgCl2, MnCl2, CaCl2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87416207"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87416207"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87416207; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87416207]").text(description); $(".js-view-count[data-work-id=87416207]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87416207; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87416207']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87416207, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87416207]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87416207,"title":"Characterization of Alkaline phosphatase (E.C.3.1.3.1) From Giant African Snail (Archachatina marginata)","translated_title":"","metadata":{"abstract":"Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The Km and Vmax were estimated to be 0.10 mM and 1.37 渭mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min.Metals (MgCl2, MnCl2, CaCl2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue."},"translated_abstract":"Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The Km and Vmax were estimated to be 0.10 mM and 1.37 渭mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min.Metals (MgCl2, MnCl2, CaCl2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.","internal_url":"https://www.academia.edu/87416207/Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_","translated_internal_url":"","created_at":"2022-09-27T06:13:31.100-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87416041"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416041/Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review"><img alt="Research paper thumbnail of Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416041/Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review">Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review</a></div><div class="wp-workCard_item"><span>South African Journal of Botany</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87416041"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87416041"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87416041; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87416041]").text(description); $(".js-view-count[data-work-id=87416041]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87416041; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87416041']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87416041, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87416041]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87416041,"title":"Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"South African Journal of Botany"},"translated_abstract":null,"internal_url":"https://www.academia.edu/87416041/Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review","translated_internal_url":"","created_at":"2022-09-27T06:11:04.619-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine"},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology"},{"id":9846,"name":"Ecology","url":"https://www.academia.edu/Documents/in/Ecology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":195890,"name":"Genus","url":"https://www.academia.edu/Documents/in/Genus"},{"id":377581,"name":"Aloe Vera","url":"https://www.academia.edu/Documents/in/Aloe_Vera"}],"urls":[{"id":24231070,"url":"https://api.elsevier.com/content/article/PII:S025462992200268X?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80530651"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80530651/Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer"><img alt="Research paper thumbnail of Additional file 1 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80530651/Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer">Additional file 1 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rapidly-progressing and slow-progressing GBM patients. (XLSX 66.7 kb)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80530651"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80530651"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80530651; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80530651]").text(description); $(".js-view-count[data-work-id=80530651]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80530651; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80530651']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80530651, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=80530651]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80530651,"title":"Additional file 1 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer","translated_title":"","metadata":{"abstract":"Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rapidly-progressing and slow-progressing GBM patients. (XLSX 66.7 kb)","publisher":"Figshare","publication_date":{"day":4,"month":4,"year":2018,"errors":{}}},"translated_abstract":"Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rapidly-progressing and slow-progressing GBM patients. (XLSX 66.7 kb)","internal_url":"https://www.academia.edu/80530651/Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_internal_url":"","created_at":"2022-06-02T05:45:10.889-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70153108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70153108/Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer"><img alt="Research paper thumbnail of Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70153108/Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer">Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a cancer would aid the identification of most, if not all, genes responsible for its progression and the development of molecularly targeted chemotherapy. The challenge of recurrence after treatment shows that our understanding of cancer mechanisms is still poor. As a contribution to overcoming this challenge, we provide an integrative multi-omic analysis on glioblastoma multiforme (GBM) for which large data sets on different classes of genomic and epigenomic alterations have been made available in the Cancer Genome Atlas data portal. The first part of this study involves protein network analysis for the elucidation of GBM tumourigenic molecular mechanisms, identification of driver genes, prioritisation of genes in chromosomal regions with copy number alteration, and c...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70153108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70153108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70153108; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70153108]").text(description); $(".js-view-count[data-work-id=70153108]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70153108; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70153108']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70153108, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=70153108]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70153108,"title":"Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer","translated_title":"","metadata":{"abstract":"Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a cancer would aid the identification of most, if not all, genes responsible for its progression and the development of molecularly targeted chemotherapy. The challenge of recurrence after treatment shows that our understanding of cancer mechanisms is still poor. As a contribution to overcoming this challenge, we provide an integrative multi-omic analysis on glioblastoma multiforme (GBM) for which large data sets on different classes of genomic and epigenomic alterations have been made available in the Cancer Genome Atlas data portal. The first part of this study involves protein network analysis for the elucidation of GBM tumourigenic molecular mechanisms, identification of driver genes, prioritisation of genes in chromosomal regions with copy number alteration, and c...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a cancer would aid the identification of most, if not all, genes responsible for its progression and the development of molecularly targeted chemotherapy. The challenge of recurrence after treatment shows that our understanding of cancer mechanisms is still poor. As a contribution to overcoming this challenge, we provide an integrative multi-omic analysis on glioblastoma multiforme (GBM) for which large data sets on different classes of genomic and epigenomic alterations have been made available in the Cancer Genome Atlas data portal. The first part of this study involves protein network analysis for the elucidation of GBM tumourigenic molecular mechanisms, identification of driver genes, prioritisation of genes in chromosomal regions with copy number alteration, and c...","internal_url":"https://www.academia.edu/70153108/Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer","translated_internal_url":"","created_at":"2022-01-31T06:46:48.084-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[{"id":17163352,"url":"http://etd.uwc.ac.za/xmlui/bitstream/handle/11394/4782/Fatai_ay_phd_nsc_2015.pdf?isAllowed=y\u0026sequence=1"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978156/Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles"><img alt="Research paper thumbnail of Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978156/Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles">Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles</a></div><div class="wp-workCard_item"><span>Oncotarget</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk gro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups. Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978156]").text(description); $(".js-view-count[data-work-id=63978156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978156,"title":"Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles","translated_title":"","metadata":{"abstract":"Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups. Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.","publisher":"Impact Journals, LLC","publication_name":"Oncotarget"},"translated_abstract":"Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups. Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.","internal_url":"https://www.academia.edu/63978156/Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles","translated_internal_url":"","created_at":"2021-12-13T10:17:22.053-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[{"id":15040570,"url":"https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.27808"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978155"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978155/Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma"><img alt="Research paper thumbnail of Predicting amplification of MYCN using CpG methylation biomarkers in neuroblastoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978155/Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma">Predicting amplification of MYCN using CpG methylation biomarkers in neuroblastoma</a></div><div class="wp-workCard_item"><span>Future Oncology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups. Differential methylation analysis, clustering, recursive feature elimination (RFE), machine learning (ML), Cox regression analysis and Kaplan鈥揗eier estimates were performed. Results and Conclusion: 663 CpGs were differentially methylated between the two groups. A total of聽25 CpGs were selected by RFE for clustering and ML, and a 100% clustering accuracy was obtained. ML validation on three external datasets produced high accuracy scores of 100%, 97% and 93%. Eight survival-associated CpGs were also identified. Therapeutic interventions may need to be targeted to patient subgroups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978155"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978155]").text(description); $(".js-view-count[data-work-id=63978155]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978155']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978155, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978155]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978155,"title":"Predicting amplification of MYCN using CpG methylation biomarkers in neuroblastoma","translated_title":"","metadata":{"abstract":"Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups. Differential methylation analysis, clustering, recursive feature elimination (RFE), machine learning (ML), Cox regression analysis and Kaplan鈥揗eier estimates were performed. Results and Conclusion: 663 CpGs were differentially methylated between the two groups. A total of聽25 CpGs were selected by RFE for clustering and ML, and a 100% clustering accuracy was obtained. ML validation on three external datasets produced high accuracy scores of 100%, 97% and 93%. Eight survival-associated CpGs were also identified. Therapeutic interventions may need to be targeted to patient subgroups.","publisher":"Future Medicine Ltd","publication_name":"Future Oncology"},"translated_abstract":"Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups. Differential methylation analysis, clustering, recursive feature elimination (RFE), machine learning (ML), Cox regression analysis and Kaplan鈥揗eier estimates were performed. Results and Conclusion: 663 CpGs were differentially methylated between the two groups. A total of聽25 CpGs were selected by RFE for clustering and ML, and a 100% clustering accuracy was obtained. ML validation on three external datasets produced high accuracy scores of 100%, 97% and 93%. Eight survival-associated CpGs were also identified. Therapeutic interventions may need to be targeted to patient subgroups.","internal_url":"https://www.academia.edu/63978155/Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma","translated_internal_url":"","created_at":"2021-12-13T10:17:21.921-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978154/Antidiabetic_Functional_Foods_with_Antiglycation_Properties"><img alt="Research paper thumbnail of Antidiabetic Functional Foods with Antiglycation Properties" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978154/Antidiabetic_Functional_Foods_with_Antiglycation_Properties">Antidiabetic Functional Foods with Antiglycation Properties</a></div><div class="wp-workCard_item"><span>Bioactive Molecules in Food</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978154]").text(description); $(".js-view-count[data-work-id=63978154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978154, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978154,"title":"Antidiabetic Functional Foods with Antiglycation Properties","translated_title":"","metadata":{"publisher":"Springer International Publishing","publication_name":"Bioactive Molecules in Food"},"translated_abstract":null,"internal_url":"https://www.academia.edu/63978154/Antidiabetic_Functional_Foods_with_Antiglycation_Properties","translated_internal_url":"","created_at":"2021-12-13T10:17:21.713-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antidiabetic_Functional_Foods_with_Antiglycation_Properties","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"}],"urls":[{"id":15040569,"url":"http://link.springer.com/content/pdf/10.1007/978-3-319-78030-6_16"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978153"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978153/Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications"><img alt="Research paper thumbnail of Laurus Nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978153/Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications">Laurus Nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications</a></div><div class="wp-workCard_item"><span>Current Enzyme Inhibition</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The rising incidence of diabetic complications necessitate the continuous search for ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper, and effective pharmacological agents. The polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. Objective: This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Methods: Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme), and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and inhibition percentages were determined. Results: The results showed that bay extract had effective IC50 for the inhibition of both aldose reductase (174.87 渭g/mL) and sorbitol dehydrogenase (37.08 渭g/mL). It also revealed that bay extract inhibi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978153"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978153; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978153]").text(description); $(".js-view-count[data-work-id=63978153]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978153; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978153']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978153, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978153]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978153,"title":"Laurus Nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications","translated_title":"","metadata":{"abstract":"Background: The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper, and effective pharmacological agents. The polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. Objective: This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Methods: Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme), and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and inhibition percentages were determined. Results: The results showed that bay extract had effective IC50 for the inhibition of both aldose reductase (174.87 渭g/mL) and sorbitol dehydrogenase (37.08 渭g/mL). It also revealed that bay extract inhibi...","publisher":"Bentham Science Publishers Ltd.","publication_name":"Current Enzyme Inhibition"},"translated_abstract":"Background: The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper, and effective pharmacological agents. The polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. Objective: This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Methods: Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme), and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and inhibition percentages were determined. Results: The results showed that bay extract had effective IC50 for the inhibition of both aldose reductase (174.87 渭g/mL) and sorbitol dehydrogenase (37.08 渭g/mL). It also revealed that bay extract inhibi...","internal_url":"https://www.academia.edu/63978153/Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications","translated_internal_url":"","created_at":"2021-12-13T10:17:21.536-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[{"id":15040568,"url":"https://eurekaselect.com/article/download/191733"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978152/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste"><img alt="Research paper thumbnail of Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978152/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste">Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste</a></div><div class="wp-workCard_item"><span>AFRICAN JOURNAL OF BIOTECHNOLOGY</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. 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The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.","publication_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY"},"translated_abstract":"A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.","internal_url":"https://www.academia.edu/63978152/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste","translated_internal_url":"","created_at":"2021-12-13T10:17:21.420-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978110/A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer"><img alt="Research paper thumbnail of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/76224171/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978110/A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer">A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer</a></div><div class="wp-workCard_item"><span>BMC Cancer</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2a5b90a99d111d4086775ecdcca9940" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":76224171,"asset_id":63978110,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/76224171/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978110; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978110]").text(description); $(".js-view-count[data-work-id=63978110]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978110; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978110']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978110, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway and machine learning based methods in adjuvant therapy-linked glioblastoma multiforme (GBM) patients from the Cancer Genome Atlas. Methods: Genes with high expression variance was subjected to pathway enrichment analysis and those having roles in chemoradioresistance pathways were used in expression-based feature selection. A modified Support Vector Machine Recursive Feature Elimination algorithm was employed to select a subset of these genes that discriminated between rapidly-progressing and slowly-progressing patients. Results: Survival analysis on TCGA samples not used in feature selection and samples from four GBM subclasses, as well as from an entirely independent study, showed that the 35-gene signature discriminated between the survival groups in all cases (p \u003c 0.05) and could accurately predict survival irrespective of the subtype. In a multivariate analysis, the signature predicted progression-free and overall survival independently of other factors considered. Conclusion: We propose that the performance of the signature makes it an attractive candidate for further studies to assess its utility as a clinical prognostic and predictive biomarker in GBM patients. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59046202"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/59046202/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_"><img alt="Research paper thumbnail of Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)" class="work-thumbnail" src="https://attachments.academia-assets.com/73164911/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/59046202/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_">Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digesti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fc11feacfe0b580ba7d981d96517c5f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":73164911,"asset_id":59046202,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/73164911/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59046202"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59046202"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59046202; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59046202]").text(description); $(".js-view-count[data-work-id=59046202]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 59046202; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='59046202']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 59046202, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fc11feacfe0b580ba7d981d96517c5f3" } } $('.js-work-strip[data-work-id=59046202]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59046202,"title":"Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)","translated_title":"","metadata":{"abstract":"Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue."},"translated_abstract":"Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.","internal_url":"https://www.academia.edu/59046202/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_","translated_internal_url":"","created_at":"2021-10-19T10:13:32.281-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":73164911,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/73164911/thumbnails/1.jpg","file_name":"Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf","download_url":"https://www.academia.edu/attachments/73164911/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterization_of_alkaline_alkaline_ph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/73164911/Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf?1634663684=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_alkaline_alkaline_ph.pdf\u0026Expires=1733257053\u0026Signature=EuBFGZL6b8~4zieS2lCWi27Rhk~z-1bsG7cJMwVoLVbNUkHaNrtRAyvlxJEgJ-Gv6qvnXIRRKabHdNWnlkf4ddArpcq2B-PbTP45TFRCRKmXTDVciO6Nk58prY2zGQAPh5TuS3A3MVTLr94FMeZp9e9UHdekmAApqWpzb2brRfdgkRXeuOMp5KJx~L1LmJimU9y55ERtMlVbY2VnH0avUtPO-7i0C2oADRTCy2TaBwfdlD-YbkXYVfy2g4J95TL81aXkOR1qfi0ss0qPYeB15i5swsQxwWpuiMDW5fG3BRiDWWRWwOZRzAQb9soLXGRmOCh-yzy4MvgoxeGUpJk6NA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[{"id":73164911,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/73164911/thumbnails/1.jpg","file_name":"Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf","download_url":"https://www.academia.edu/attachments/73164911/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterization_of_alkaline_alkaline_ph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/73164911/Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf?1634663684=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_alkaline_alkaline_ph.pdf\u0026Expires=1733257053\u0026Signature=EuBFGZL6b8~4zieS2lCWi27Rhk~z-1bsG7cJMwVoLVbNUkHaNrtRAyvlxJEgJ-Gv6qvnXIRRKabHdNWnlkf4ddArpcq2B-PbTP45TFRCRKmXTDVciO6Nk58prY2zGQAPh5TuS3A3MVTLr94FMeZp9e9UHdekmAApqWpzb2brRfdgkRXeuOMp5KJx~L1LmJimU9y55ERtMlVbY2VnH0avUtPO-7i0C2oADRTCy2TaBwfdlD-YbkXYVfy2g4J95TL81aXkOR1qfi0ss0qPYeB15i5swsQxwWpuiMDW5fG3BRiDWWRWwOZRzAQb9soLXGRmOCh-yzy4MvgoxeGUpJk6NA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21205121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21205121/Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats"><img alt="Research paper thumbnail of Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats" class="work-thumbnail" src="https://attachments.academia-assets.com/41761742/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21205121/Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats">Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induced hepatotoxic rats was investigated. The first set of animals received only ginger-supplemented diet while the other set were treated with CCl4 before maintaining them on ginger-based diets. Consumption of the experimental diets by the normal rats produced significant elevation (p&lt;0.05) in the activities of the hepatic aspartate aminotransferase and alanine amonotransferase as well as the concentration of protein and albumin. Kidney function analysis showed that the concentration of urea and potassium ion (K+) were significantly affected (p&lt;0.05) while other electrolytes were not (p&gt;0.05). However, all the haematological parameters of the rats were not significantly affected (p&gt;0.05) by the experiment. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters and antioxidant enzymes. However, the significantly reduced (p&lt;0...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e52dfeeea1ed2d5c5c940a8a1a75db02" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41761742,"asset_id":21205121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41761742/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21205121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21205121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205121]").text(description); $(".js-view-count[data-work-id=21205121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21205121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21205121, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e52dfeeea1ed2d5c5c940a8a1a75db02" } } $('.js-work-strip[data-work-id=21205121]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21205121,"title":"Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats","translated_title":"","metadata":{"abstract":"The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induced hepatotoxic rats was investigated. The first set of animals received only ginger-supplemented diet while the other set were treated with CCl4 before maintaining them on ginger-based diets. Consumption of the experimental diets by the normal rats produced significant elevation (p\u0026lt;0.05) in the activities of the hepatic aspartate aminotransferase and alanine amonotransferase as well as the concentration of protein and albumin. Kidney function analysis showed that the concentration of urea and potassium ion (K+) were significantly affected (p\u0026lt;0.05) while other electrolytes were not (p\u0026gt;0.05). However, all the haematological parameters of the rats were not significantly affected (p\u0026gt;0.05) by the experiment. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters and antioxidant enzymes. However, the significantly reduced (p\u0026lt;0..."},"translated_abstract":"The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induced hepatotoxic rats was investigated. The first set of animals received only ginger-supplemented diet while the other set were treated with CCl4 before maintaining them on ginger-based diets. Consumption of the experimental diets by the normal rats produced significant elevation (p\u0026lt;0.05) in the activities of the hepatic aspartate aminotransferase and alanine amonotransferase as well as the concentration of protein and albumin. Kidney function analysis showed that the concentration of urea and potassium ion (K+) were significantly affected (p\u0026lt;0.05) while other electrolytes were not (p\u0026gt;0.05). However, all the haematological parameters of the rats were not significantly affected (p\u0026gt;0.05) by the experiment. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters and antioxidant enzymes. However, the significantly reduced (p\u0026lt;0...","internal_url":"https://www.academia.edu/21205121/Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats","translated_internal_url":"","created_at":"2016-01-29T22:58:43.330-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14202417,"work_id":21205121,"tagging_user_id":42358348,"tagged_user_id":null,"co_author_invite_id":3300102,"email":"3***1@uwc.ac.za","display_order":0,"name":"Habeeb Bankole","title":"Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats"},{"id":14202418,"work_id":21205121,"tagging_user_id":42358348,"tagged_user_id":null,"co_author_invite_id":3300103,"email":"t***n@yahoo.co.uk","display_order":4194304,"name":"Mutiu Kazeem","title":"Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats"}],"downloadable_attachments":[{"id":41761742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41761742/thumbnails/1.jpg","file_name":"Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf.pdf","download_url":"https://www.academia.edu/attachments/41761742/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protective_effect_of_ginger_in_normal_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41761742/Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf-libre.pdf?1454137219=\u0026response-content-disposition=attachment%3B+filename%3DProtective_effect_of_ginger_in_normal_an.pdf\u0026Expires=1733257053\u0026Signature=Bk7wVJ-W99ao8OsfZi9pDNjA4wRjrQp8IVJHjCU5k-N5gXSCQWnTq0DYqQg9OzCP2Tm0b-Fx3~VCHf7nHNynrarYt9XqM1Zo4mPPnuAkku-8CQ-9XvZRI4njGl61IvKTmcqE4RZFKGVy5Ca7rhcbZRQODSC2q4rDWMMTqK83wLCs1LoWvWVmWpjWQxTZ47eW4Jbsm6i-jy4h1dJM5bpDFhHgF5mPCoCew8FlZn7OgR5RwHMPV46gMLycm~q6g0IE9EsRN3NrXuEFFUAorPltfap1NdAUPM6MPpxc3BeetPCcwvXeyYSEOFZmFQvyWqYvaBcgADGApK8jINwqmpVOHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[{"id":41761742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41761742/thumbnails/1.jpg","file_name":"Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf.pdf","download_url":"https://www.academia.edu/attachments/41761742/download_file?st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protective_effect_of_ginger_in_normal_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41761742/Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf-libre.pdf?1454137219=\u0026response-content-disposition=attachment%3B+filename%3DProtective_effect_of_ginger_in_normal_an.pdf\u0026Expires=1733257053\u0026Signature=Bk7wVJ-W99ao8OsfZi9pDNjA4wRjrQp8IVJHjCU5k-N5gXSCQWnTq0DYqQg9OzCP2Tm0b-Fx3~VCHf7nHNynrarYt9XqM1Zo4mPPnuAkku-8CQ-9XvZRI4njGl61IvKTmcqE4RZFKGVy5Ca7rhcbZRQODSC2q4rDWMMTqK83wLCs1LoWvWVmWpjWQxTZ47eW4Jbsm6i-jy4h1dJM5bpDFhHgF5mPCoCew8FlZn7OgR5RwHMPV46gMLycm~q6g0IE9EsRN3NrXuEFFUAorPltfap1NdAUPM6MPpxc3BeetPCcwvXeyYSEOFZmFQvyWqYvaBcgADGApK8jINwqmpVOHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21205120"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21205120/Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs"><img alt="Research paper thumbnail of Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21205120/Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs">Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs</a></div><div class="wp-workCard_item"><span>Asian Journal of Biochemistry</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extrac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg -1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p&amp;lt;0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg -1 group showing significant difference compared to lower-dose and saline groups (p&amp;lt;0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21205120"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21205120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205120]").text(description); $(".js-view-count[data-work-id=21205120]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21205120']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21205120, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21205120]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21205120,"title":"Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs","translated_title":"","metadata":{"abstract":"ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg -1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p\u0026amp;lt;0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg -1 group showing significant difference compared to lower-dose and saline groups (p\u0026amp;lt;0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Asian Journal of Biochemistry"},"translated_abstract":"ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg -1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p\u0026amp;lt;0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg -1 group showing significant difference compared to lower-dose and saline groups (p\u0026amp;lt;0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.","internal_url":"https://www.academia.edu/21205120/Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs","translated_internal_url":"","created_at":"2016-01-29T22:58:43.208-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14202416,"work_id":21205120,"tagging_user_id":42358348,"tagged_user_id":null,"co_author_invite_id":3300102,"email":"3***1@uwc.ac.za","display_order":0,"name":"Habeeb Bankole","title":"Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs"},{"id":14202419,"work_id":21205120,"tagging_user_id":42358348,"tagged_user_id":12445258,"co_author_invite_id":null,"email":"o***u@lasu.edu.ng","affiliation":"Lagos State University, Lagos, Nigeria","display_order":4194304,"name":"Oluwatosin Adu","title":"Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs"}],"downloadable_attachments":[],"slug":"Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15808408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15808408/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste"><img alt="Research paper thumbnail of Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste" class="work-thumbnail" src="https://attachments.academia-assets.com/41205946/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15808408/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste">Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://lasunigeria.academia.edu/BabajideElemo">Babajide Elemo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ORaimi">Olawale Raimi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/Fatai">Azeez Fatai</a></span></div><div class="wp-workCard_item"><span>AFRICAN JOURNAL OF BIOTECHNOLOGY</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d620b3390bfac8bc93ae91d3a2c97d04" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41205946,"asset_id":15808408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41205946/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15808408"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15808408"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15808408; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15808408]").text(description); $(".js-view-count[data-work-id=15808408]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15808408; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15808408']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15808408, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d620b3390bfac8bc93ae91d3a2c97d04" } } $('.js-work-strip[data-work-id=15808408]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15808408,"title":"Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste","translated_title":"","metadata":{"abstract":"A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.","ai_title_tag":"Characterization of a Protease from Thaumatococcus daniellii Waste","publication_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY"},"translated_abstract":"A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15808416"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15808416/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_"><img alt="Research paper thumbnail of Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)" class="work-thumbnail" src="https://attachments.academia-assets.com/41205953/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15808416/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_">Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ORaimi">Olawale Raimi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/Fatai">Azeez Fatai</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digesti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a8b10801862df9b21cf84729721e86ac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41205953,"asset_id":15808416,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41205953/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15808416"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15808416"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15808416; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15808416]").text(description); $(".js-view-count[data-work-id=15808416]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15808416; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15808416']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15808416, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a8b10801862df9b21cf84729721e86ac" } } $('.js-work-strip[data-work-id=15808416]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15808416,"title":"Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)","translated_title":"","metadata":{"abstract":"Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. 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(PDF 23.5 kb)","internal_url":"https://www.academia.edu/87416222/Additional_file_2_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_internal_url":"","created_at":"2022-09-27T06:13:41.355-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Additional_file_2_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":1083,"name":"Developmental Biology","url":"https://www.academia.edu/Documents/in/Developmental_Biology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":463461,"name":"Glioblastoma Multiforme","url":"https://www.academia.edu/Documents/in/Glioblastoma_Multiforme"},{"id":4011260,"name":"Risk groups","url":"https://www.academia.edu/Documents/in/Risk_groups"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87416213"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416213/Combined_Oral_Administration_of_Ethinylestradiol_and_Levonorgestrel_Alters_the_Expression_of_Antioxidant_and_Apoptotic_Markers_in_Female_Rats"><img alt="Research paper thumbnail of Combined Oral Administration of Ethinylestradiol and Levonorgestrel Alters the Expression of Antioxidant and Apoptotic Markers in Female Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/91629278/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416213/Combined_Oral_Administration_of_Ethinylestradiol_and_Levonorgestrel_Alters_the_Expression_of_Antioxidant_and_Apoptotic_Markers_in_Female_Rats">Combined Oral Administration of Ethinylestradiol and Levonorgestrel Alters the Expression of Antioxidant and Apoptotic Markers in Female Rats</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The use of ethinylestradiol and levonorgestrel (E/L) for birth control may result in serious adve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The use of ethinylestradiol and levonorgestrel (E/L) for birth control may result in serious adverse effects. Herein, the effect of (E/L) on the expression of genes encoding antioxidant enzymes (superoxide dismutase (SOD) and Catalase (CAT)), and apoptotic regulator genes (B-cell lymphoma 2 (BCL-2), caspase 1 and 3) was evaluated. Thirty-two rats were randomly divided into four equal groups. Group A (Control) received 0.5% DMSO, Group B, C and D received 0.015, 0.030, and 0.060 mg of E/L orally and daily for 21 days respectively. RNA extracted from brain, liver and kidney were purified, and the genes amplified using RT-PCR. Following analysis of the intensity of the amplicon bands on 1.2% agarose, the gene&#39;s relative expression compared with the expression 尾actin was determined. There was significant downregulation of SOD and CAT genes in the liver, brain and kidney in all groups treated with E/L compared to control. Caspase 1 and 3 expressions were significantly elevated by 3.8...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="12b6e9fd3ce47ac33d1a9b7ff9be92f5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91629278,"asset_id":87416213,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91629278/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87416213"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87416213"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87416213; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87416213]").text(description); $(".js-view-count[data-work-id=87416213]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87416213; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87416213']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87416213, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "12b6e9fd3ce47ac33d1a9b7ff9be92f5" } } $('.js-work-strip[data-work-id=87416213]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87416213,"title":"Combined Oral Administration of Ethinylestradiol and Levonorgestrel Alters the Expression of Antioxidant and Apoptotic Markers in Female Rats","translated_title":"","metadata":{"abstract":"The use of ethinylestradiol and levonorgestrel (E/L) for birth control may result in serious adverse effects. Herein, the effect of (E/L) on the expression of genes encoding antioxidant enzymes (superoxide dismutase (SOD) and Catalase (CAT)), and apoptotic regulator genes (B-cell lymphoma 2 (BCL-2), caspase 1 and 3) was evaluated. Thirty-two rats were randomly divided into four equal groups. Group A (Control) received 0.5% DMSO, Group B, C and D received 0.015, 0.030, and 0.060 mg of E/L orally and daily for 21 days respectively. RNA extracted from brain, liver and kidney were purified, and the genes amplified using RT-PCR. Following analysis of the intensity of the amplicon bands on 1.2% agarose, the gene\u0026#39;s relative expression compared with the expression 尾actin was determined. There was significant downregulation of SOD and CAT genes in the liver, brain and kidney in all groups treated with E/L compared to control. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87416207"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416207/Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_"><img alt="Research paper thumbnail of Characterization of Alkaline phosphatase (E.C.3.1.3.1) From Giant African Snail (Archachatina marginata)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416207/Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_">Characterization of Alkaline phosphatase (E.C.3.1.3.1) From Giant African Snail (Archachatina marginata)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The Km and Vmax were estimated to be 0.10 mM and 1.37 渭mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min.Metals (MgCl2, MnCl2, CaCl2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87416207"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87416207"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87416207; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87416207]").text(description); $(".js-view-count[data-work-id=87416207]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87416207; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87416207']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87416207, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87416207]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87416207,"title":"Characterization of Alkaline phosphatase (E.C.3.1.3.1) From Giant African Snail (Archachatina marginata)","translated_title":"","metadata":{"abstract":"Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The Km and Vmax were estimated to be 0.10 mM and 1.37 渭mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min.Metals (MgCl2, MnCl2, CaCl2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue."},"translated_abstract":"Abstract: Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The Km and Vmax were estimated to be 0.10 mM and 1.37 渭mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min.Metals (MgCl2, MnCl2, CaCl2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.","internal_url":"https://www.academia.edu/87416207/Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_","translated_internal_url":"","created_at":"2022-09-27T06:13:31.100-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Characterization_of_Alkaline_phosphatase_E_C_3_1_3_1_From_Giant_African_Snail_Archachatina_marginata_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87416041"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87416041/Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review"><img alt="Research paper thumbnail of Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87416041/Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review">Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review</a></div><div class="wp-workCard_item"><span>South African Journal of Botany</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87416041"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87416041"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87416041; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87416041]").text(description); $(".js-view-count[data-work-id=87416041]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87416041; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87416041']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87416041, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87416041]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87416041,"title":"Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"South African Journal of Botany"},"translated_abstract":null,"internal_url":"https://www.academia.edu/87416041/Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review","translated_internal_url":"","created_at":"2022-09-27T06:11:04.619-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Genus_Aloe_as_sources_of_antidiabetic_antihyperglycemic_and_hypoglycemic_agents_A_review","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine"},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology"},{"id":9846,"name":"Ecology","url":"https://www.academia.edu/Documents/in/Ecology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":195890,"name":"Genus","url":"https://www.academia.edu/Documents/in/Genus"},{"id":377581,"name":"Aloe Vera","url":"https://www.academia.edu/Documents/in/Aloe_Vera"}],"urls":[{"id":24231070,"url":"https://api.elsevier.com/content/article/PII:S025462992200268X?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80530651"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80530651/Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer"><img alt="Research paper thumbnail of Additional file 1 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80530651/Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer">Additional file 1 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rapidly-progressing and slow-progressing GBM patients. (XLSX 66.7 kb)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80530651"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80530651"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80530651; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80530651]").text(description); $(".js-view-count[data-work-id=80530651]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80530651; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80530651']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80530651, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=80530651]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80530651,"title":"Additional file 1 of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer","translated_title":"","metadata":{"abstract":"Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rapidly-progressing and slow-progressing GBM patients. (XLSX 66.7 kb)","publisher":"Figshare","publication_date":{"day":4,"month":4,"year":2018,"errors":{}}},"translated_abstract":"Workflow of the modified SVM-RFE used for selecting a set of genes that discriminated between rapidly-progressing and slow-progressing GBM patients. (XLSX 66.7 kb)","internal_url":"https://www.academia.edu/80530651/Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_internal_url":"","created_at":"2022-06-02T05:45:10.889-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Additional_file_1_of_A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70153108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70153108/Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer"><img alt="Research paper thumbnail of Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70153108/Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer">Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a cancer would aid the identification of most, if not all, genes responsible for its progression and the development of molecularly targeted chemotherapy. The challenge of recurrence after treatment shows that our understanding of cancer mechanisms is still poor. As a contribution to overcoming this challenge, we provide an integrative multi-omic analysis on glioblastoma multiforme (GBM) for which large data sets on different classes of genomic and epigenomic alterations have been made available in the Cancer Genome Atlas data portal. The first part of this study involves protein network analysis for the elucidation of GBM tumourigenic molecular mechanisms, identification of driver genes, prioritisation of genes in chromosomal regions with copy number alteration, and c...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70153108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70153108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70153108; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70153108]").text(description); $(".js-view-count[data-work-id=70153108]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70153108; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70153108']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70153108, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=70153108]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70153108,"title":"Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer","translated_title":"","metadata":{"abstract":"Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a cancer would aid the identification of most, if not all, genes responsible for its progression and the development of molecularly targeted chemotherapy. The challenge of recurrence after treatment shows that our understanding of cancer mechanisms is still poor. As a contribution to overcoming this challenge, we provide an integrative multi-omic analysis on glioblastoma multiforme (GBM) for which large data sets on different classes of genomic and epigenomic alterations have been made available in the Cancer Genome Atlas data portal. The first part of this study involves protein network analysis for the elucidation of GBM tumourigenic molecular mechanisms, identification of driver genes, prioritisation of genes in chromosomal regions with copy number alteration, and c...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a cancer would aid the identification of most, if not all, genes responsible for its progression and the development of molecularly targeted chemotherapy. The challenge of recurrence after treatment shows that our understanding of cancer mechanisms is still poor. As a contribution to overcoming this challenge, we provide an integrative multi-omic analysis on glioblastoma multiforme (GBM) for which large data sets on different classes of genomic and epigenomic alterations have been made available in the Cancer Genome Atlas data portal. The first part of this study involves protein network analysis for the elucidation of GBM tumourigenic molecular mechanisms, identification of driver genes, prioritisation of genes in chromosomal regions with copy number alteration, and c...","internal_url":"https://www.academia.edu/70153108/Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer","translated_internal_url":"","created_at":"2022-01-31T06:46:48.084-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Computational_analysis_of_multilevel_omics_data_for_the_elucidation_of_molecular_mechanisms_of_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[{"id":17163352,"url":"http://etd.uwc.ac.za/xmlui/bitstream/handle/11394/4782/Fatai_ay_phd_nsc_2015.pdf?isAllowed=y\u0026sequence=1"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978156/Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles"><img alt="Research paper thumbnail of Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978156/Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles">Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles</a></div><div class="wp-workCard_item"><span>Oncotarget</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk gro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups. Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978156]").text(description); $(".js-view-count[data-work-id=63978156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978156,"title":"Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles","translated_title":"","metadata":{"abstract":"Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups. Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.","publisher":"Impact Journals, LLC","publication_name":"Oncotarget"},"translated_abstract":"Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets. RNA-seq count data was downloaded from UCSC Xena browser and samples grouped into Short Survival (SS) and Long Survival (LS) groups. Differential gene expression (DGE) analysis, enrichment analyses, regulatory network analysis and machine learning (ML) prediction of survival group were performed. Forty differentially expressed genes (DEGs) were identified including genes involved in molecular function activities essential for tumor proliferation. DEGs used as features for prediction of survival groups included EVX2, NHLH2, PRSS12, POU6F2, HOXD10, MAPK15, RTL1, LGR5, CYP17A1, OR10AB1P, MYH14, LRRTM3, GRIN3A, HS3ST5, CRYAB and NXPH3. An accuracy score of 82% was obtained by the ML classification models. SMIM28 was revealed to possibly have a role in tumor proliferation and aggressiveness. Our results indicate that these DEGs can serve as prognostic indicators of survival in high-risk neuroblastoma patients and will assist clinicians in making better therapeutic and patient management decisions.","internal_url":"https://www.academia.edu/63978156/Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles","translated_internal_url":"","created_at":"2021-12-13T10:17:22.053-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Identification_of_novel_prognostic_markers_of_survival_time_in_high_risk_neuroblastoma_using_gene_expression_profiles","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[{"id":15040570,"url":"https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.27808"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978155"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978155/Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma"><img alt="Research paper thumbnail of Predicting amplification of MYCN using CpG methylation biomarkers in neuroblastoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978155/Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma">Predicting amplification of MYCN using CpG methylation biomarkers in neuroblastoma</a></div><div class="wp-workCard_item"><span>Future Oncology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups. Differential methylation analysis, clustering, recursive feature elimination (RFE), machine learning (ML), Cox regression analysis and Kaplan鈥揗eier estimates were performed. Results and Conclusion: 663 CpGs were differentially methylated between the two groups. A total of聽25 CpGs were selected by RFE for clustering and ML, and a 100% clustering accuracy was obtained. ML validation on three external datasets produced high accuracy scores of 100%, 97% and 93%. Eight survival-associated CpGs were also identified. Therapeutic interventions may need to be targeted to patient subgroups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978155"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978155]").text(description); $(".js-view-count[data-work-id=63978155]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978155']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978155, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978155]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978155,"title":"Predicting amplification of MYCN using CpG methylation biomarkers in neuroblastoma","translated_title":"","metadata":{"abstract":"Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups. Differential methylation analysis, clustering, recursive feature elimination (RFE), machine learning (ML), Cox regression analysis and Kaplan鈥揗eier estimates were performed. Results and Conclusion: 663 CpGs were differentially methylated between the two groups. A total of聽25 CpGs were selected by RFE for clustering and ML, and a 100% clustering accuracy was obtained. ML validation on three external datasets produced high accuracy scores of 100%, 97% and 93%. Eight survival-associated CpGs were also identified. Therapeutic interventions may need to be targeted to patient subgroups.","publisher":"Future Medicine Ltd","publication_name":"Future Oncology"},"translated_abstract":"Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups. Differential methylation analysis, clustering, recursive feature elimination (RFE), machine learning (ML), Cox regression analysis and Kaplan鈥揗eier estimates were performed. Results and Conclusion: 663 CpGs were differentially methylated between the two groups. A total of聽25 CpGs were selected by RFE for clustering and ML, and a 100% clustering accuracy was obtained. ML validation on three external datasets produced high accuracy scores of 100%, 97% and 93%. Eight survival-associated CpGs were also identified. Therapeutic interventions may need to be targeted to patient subgroups.","internal_url":"https://www.academia.edu/63978155/Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma","translated_internal_url":"","created_at":"2021-12-13T10:17:21.921-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Predicting_amplification_of_MYCN_using_CpG_methylation_biomarkers_in_neuroblastoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978154/Antidiabetic_Functional_Foods_with_Antiglycation_Properties"><img alt="Research paper thumbnail of Antidiabetic Functional Foods with Antiglycation Properties" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978154/Antidiabetic_Functional_Foods_with_Antiglycation_Properties">Antidiabetic Functional Foods with Antiglycation Properties</a></div><div class="wp-workCard_item"><span>Bioactive Molecules in Food</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978154]").text(description); $(".js-view-count[data-work-id=63978154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978154, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978154,"title":"Antidiabetic Functional Foods with Antiglycation Properties","translated_title":"","metadata":{"publisher":"Springer International Publishing","publication_name":"Bioactive Molecules in Food"},"translated_abstract":null,"internal_url":"https://www.academia.edu/63978154/Antidiabetic_Functional_Foods_with_Antiglycation_Properties","translated_internal_url":"","created_at":"2021-12-13T10:17:21.713-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antidiabetic_Functional_Foods_with_Antiglycation_Properties","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"}],"urls":[{"id":15040569,"url":"http://link.springer.com/content/pdf/10.1007/978-3-319-78030-6_16"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978153"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978153/Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications"><img alt="Research paper thumbnail of Laurus Nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978153/Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications">Laurus Nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications</a></div><div class="wp-workCard_item"><span>Current Enzyme Inhibition</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The rising incidence of diabetic complications necessitate the continuous search for ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper, and effective pharmacological agents. The polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. Objective: This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Methods: Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme), and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and inhibition percentages were determined. Results: The results showed that bay extract had effective IC50 for the inhibition of both aldose reductase (174.87 渭g/mL) and sorbitol dehydrogenase (37.08 渭g/mL). It also revealed that bay extract inhibi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978153"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978153; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978153]").text(description); $(".js-view-count[data-work-id=63978153]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978153; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978153']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978153, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63978153]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63978153,"title":"Laurus Nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications","translated_title":"","metadata":{"abstract":"Background: The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper, and effective pharmacological agents. The polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. Objective: This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Methods: Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme), and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and inhibition percentages were determined. Results: The results showed that bay extract had effective IC50 for the inhibition of both aldose reductase (174.87 渭g/mL) and sorbitol dehydrogenase (37.08 渭g/mL). It also revealed that bay extract inhibi...","publisher":"Bentham Science Publishers Ltd.","publication_name":"Current Enzyme Inhibition"},"translated_abstract":"Background: The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper, and effective pharmacological agents. The polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. Objective: This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Methods: Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme), and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and inhibition percentages were determined. Results: The results showed that bay extract had effective IC50 for the inhibition of both aldose reductase (174.87 渭g/mL) and sorbitol dehydrogenase (37.08 渭g/mL). It also revealed that bay extract inhibi...","internal_url":"https://www.academia.edu/63978153/Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications","translated_internal_url":"","created_at":"2021-12-13T10:17:21.536-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Laurus_Nobilis_Linn_Inhibits_Polyol_Pathway_Enzymes_Strategy_for_Managing_Diabetic_Complications","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[{"id":15040568,"url":"https://eurekaselect.com/article/download/191733"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978152/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste"><img alt="Research paper thumbnail of Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978152/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste">Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste</a></div><div class="wp-workCard_item"><span>AFRICAN JOURNAL OF BIOTECHNOLOGY</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. 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The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.","publication_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY"},"translated_abstract":"A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.","internal_url":"https://www.academia.edu/63978152/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste","translated_internal_url":"","created_at":"2021-12-13T10:17:21.420-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63978110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63978110/A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer"><img alt="Research paper thumbnail of A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/76224171/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63978110/A_35_gene_signature_discriminates_between_rapidly_and_slowly_progressing_glioblastoma_multiforme_and_predicts_survival_in_known_subtypes_of_the_cancer">A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer</a></div><div class="wp-workCard_item"><span>BMC Cancer</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2a5b90a99d111d4086775ecdcca9940" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":76224171,"asset_id":63978110,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/76224171/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63978110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63978110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63978110; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63978110]").text(description); $(".js-view-count[data-work-id=63978110]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63978110; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63978110']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63978110, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway and machine learning based methods in adjuvant therapy-linked glioblastoma multiforme (GBM) patients from the Cancer Genome Atlas. Methods: Genes with high expression variance was subjected to pathway enrichment analysis and those having roles in chemoradioresistance pathways were used in expression-based feature selection. A modified Support Vector Machine Recursive Feature Elimination algorithm was employed to select a subset of these genes that discriminated between rapidly-progressing and slowly-progressing patients. Results: Survival analysis on TCGA samples not used in feature selection and samples from four GBM subclasses, as well as from an entirely independent study, showed that the 35-gene signature discriminated between the survival groups in all cases (p \u003c 0.05) and could accurately predict survival irrespective of the subtype. In a multivariate analysis, the signature predicted progression-free and overall survival independently of other factors considered. Conclusion: We propose that the performance of the signature makes it an attractive candidate for further studies to assess its utility as a clinical prognostic and predictive biomarker in GBM patients. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59046202"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/59046202/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_"><img alt="Research paper thumbnail of Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)" class="work-thumbnail" src="https://attachments.academia-assets.com/73164911/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/59046202/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_">Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digesti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fc11feacfe0b580ba7d981d96517c5f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":73164911,"asset_id":59046202,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/73164911/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59046202"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59046202"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59046202; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59046202]").text(description); $(".js-view-count[data-work-id=59046202]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 59046202; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='59046202']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 59046202, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fc11feacfe0b580ba7d981d96517c5f3" } } $('.js-work-strip[data-work-id=59046202]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59046202,"title":"Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)","translated_title":"","metadata":{"abstract":"Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue."},"translated_abstract":"Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.","internal_url":"https://www.academia.edu/59046202/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_","translated_internal_url":"","created_at":"2021-10-19T10:13:32.281-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":73164911,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/73164911/thumbnails/1.jpg","file_name":"Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf","download_url":"https://www.academia.edu/attachments/73164911/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterization_of_alkaline_alkaline_ph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/73164911/Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf?1634663684=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_alkaline_alkaline_ph.pdf\u0026Expires=1733257053\u0026Signature=EuBFGZL6b8~4zieS2lCWi27Rhk~z-1bsG7cJMwVoLVbNUkHaNrtRAyvlxJEgJ-Gv6qvnXIRRKabHdNWnlkf4ddArpcq2B-PbTP45TFRCRKmXTDVciO6Nk58prY2zGQAPh5TuS3A3MVTLr94FMeZp9e9UHdekmAApqWpzb2brRfdgkRXeuOMp5KJx~L1LmJimU9y55ERtMlVbY2VnH0avUtPO-7i0C2oADRTCy2TaBwfdlD-YbkXYVfy2g4J95TL81aXkOR1qfi0ss0qPYeB15i5swsQxwWpuiMDW5fG3BRiDWWRWwOZRzAQb9soLXGRmOCh-yzy4MvgoxeGUpJk6NA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[{"id":73164911,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/73164911/thumbnails/1.jpg","file_name":"Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf","download_url":"https://www.academia.edu/attachments/73164911/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterization_of_alkaline_alkaline_ph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/73164911/Characterization_of_alkaline_alkaline_ph20211019-30409-18hsc5e.pdf?1634663684=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_alkaline_alkaline_ph.pdf\u0026Expires=1733257053\u0026Signature=EuBFGZL6b8~4zieS2lCWi27Rhk~z-1bsG7cJMwVoLVbNUkHaNrtRAyvlxJEgJ-Gv6qvnXIRRKabHdNWnlkf4ddArpcq2B-PbTP45TFRCRKmXTDVciO6Nk58prY2zGQAPh5TuS3A3MVTLr94FMeZp9e9UHdekmAApqWpzb2brRfdgkRXeuOMp5KJx~L1LmJimU9y55ERtMlVbY2VnH0avUtPO-7i0C2oADRTCy2TaBwfdlD-YbkXYVfy2g4J95TL81aXkOR1qfi0ss0qPYeB15i5swsQxwWpuiMDW5fG3BRiDWWRWwOZRzAQb9soLXGRmOCh-yzy4MvgoxeGUpJk6NA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21205121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21205121/Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats"><img alt="Research paper thumbnail of Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats" class="work-thumbnail" src="https://attachments.academia-assets.com/41761742/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21205121/Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats">Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induced hepatotoxic rats was investigated. The first set of animals received only ginger-supplemented diet while the other set were treated with CCl4 before maintaining them on ginger-based diets. Consumption of the experimental diets by the normal rats produced significant elevation (p&lt;0.05) in the activities of the hepatic aspartate aminotransferase and alanine amonotransferase as well as the concentration of protein and albumin. Kidney function analysis showed that the concentration of urea and potassium ion (K+) were significantly affected (p&lt;0.05) while other electrolytes were not (p&gt;0.05). However, all the haematological parameters of the rats were not significantly affected (p&gt;0.05) by the experiment. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters and antioxidant enzymes. However, the significantly reduced (p&lt;0...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e52dfeeea1ed2d5c5c940a8a1a75db02" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41761742,"asset_id":21205121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41761742/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21205121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21205121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205121]").text(description); $(".js-view-count[data-work-id=21205121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21205121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21205121, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e52dfeeea1ed2d5c5c940a8a1a75db02" } } $('.js-work-strip[data-work-id=21205121]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21205121,"title":"Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats","translated_title":"","metadata":{"abstract":"The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induced hepatotoxic rats was investigated. The first set of animals received only ginger-supplemented diet while the other set were treated with CCl4 before maintaining them on ginger-based diets. Consumption of the experimental diets by the normal rats produced significant elevation (p\u0026lt;0.05) in the activities of the hepatic aspartate aminotransferase and alanine amonotransferase as well as the concentration of protein and albumin. Kidney function analysis showed that the concentration of urea and potassium ion (K+) were significantly affected (p\u0026lt;0.05) while other electrolytes were not (p\u0026gt;0.05). However, all the haematological parameters of the rats were not significantly affected (p\u0026gt;0.05) by the experiment. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters and antioxidant enzymes. However, the significantly reduced (p\u0026lt;0..."},"translated_abstract":"The protective effect of ginger supplemented diet in normal and carbon-tetrachoride (CCl4) induced hepatotoxic rats was investigated. The first set of animals received only ginger-supplemented diet while the other set were treated with CCl4 before maintaining them on ginger-based diets. Consumption of the experimental diets by the normal rats produced significant elevation (p\u0026lt;0.05) in the activities of the hepatic aspartate aminotransferase and alanine amonotransferase as well as the concentration of protein and albumin. Kidney function analysis showed that the concentration of urea and potassium ion (K+) were significantly affected (p\u0026lt;0.05) while other electrolytes were not (p\u0026gt;0.05). However, all the haematological parameters of the rats were not significantly affected (p\u0026gt;0.05) by the experiment. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters and antioxidant enzymes. However, the significantly reduced (p\u0026lt;0...","internal_url":"https://www.academia.edu/21205121/Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats","translated_internal_url":"","created_at":"2016-01-29T22:58:43.330-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14202417,"work_id":21205121,"tagging_user_id":42358348,"tagged_user_id":null,"co_author_invite_id":3300102,"email":"3***1@uwc.ac.za","display_order":0,"name":"Habeeb Bankole","title":"Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats"},{"id":14202418,"work_id":21205121,"tagging_user_id":42358348,"tagged_user_id":null,"co_author_invite_id":3300103,"email":"t***n@yahoo.co.uk","display_order":4194304,"name":"Mutiu Kazeem","title":"Protective effect of ginger in normal and carbon tetrachloride induced hepatotoxic rats"}],"downloadable_attachments":[{"id":41761742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41761742/thumbnails/1.jpg","file_name":"Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf.pdf","download_url":"https://www.academia.edu/attachments/41761742/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protective_effect_of_ginger_in_normal_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41761742/Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf-libre.pdf?1454137219=\u0026response-content-disposition=attachment%3B+filename%3DProtective_effect_of_ginger_in_normal_an.pdf\u0026Expires=1733257053\u0026Signature=Bk7wVJ-W99ao8OsfZi9pDNjA4wRjrQp8IVJHjCU5k-N5gXSCQWnTq0DYqQg9OzCP2Tm0b-Fx3~VCHf7nHNynrarYt9XqM1Zo4mPPnuAkku-8CQ-9XvZRI4njGl61IvKTmcqE4RZFKGVy5Ca7rhcbZRQODSC2q4rDWMMTqK83wLCs1LoWvWVmWpjWQxTZ47eW4Jbsm6i-jy4h1dJM5bpDFhHgF5mPCoCew8FlZn7OgR5RwHMPV46gMLycm~q6g0IE9EsRN3NrXuEFFUAorPltfap1NdAUPM6MPpxc3BeetPCcwvXeyYSEOFZmFQvyWqYvaBcgADGApK8jINwqmpVOHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Protective_effect_of_ginger_in_normal_and_carbon_tetrachloride_induced_hepatotoxic_rats","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[{"id":41761742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41761742/thumbnails/1.jpg","file_name":"Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf.pdf","download_url":"https://www.academia.edu/attachments/41761742/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protective_effect_of_ginger_in_normal_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41761742/Protective_effect_of_ginger_in_normal_an20160129-31743-1oheozf-libre.pdf?1454137219=\u0026response-content-disposition=attachment%3B+filename%3DProtective_effect_of_ginger_in_normal_an.pdf\u0026Expires=1733257053\u0026Signature=Bk7wVJ-W99ao8OsfZi9pDNjA4wRjrQp8IVJHjCU5k-N5gXSCQWnTq0DYqQg9OzCP2Tm0b-Fx3~VCHf7nHNynrarYt9XqM1Zo4mPPnuAkku-8CQ-9XvZRI4njGl61IvKTmcqE4RZFKGVy5Ca7rhcbZRQODSC2q4rDWMMTqK83wLCs1LoWvWVmWpjWQxTZ47eW4Jbsm6i-jy4h1dJM5bpDFhHgF5mPCoCew8FlZn7OgR5RwHMPV46gMLycm~q6g0IE9EsRN3NrXuEFFUAorPltfap1NdAUPM6MPpxc3BeetPCcwvXeyYSEOFZmFQvyWqYvaBcgADGApK8jINwqmpVOHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21205120"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21205120/Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs"><img alt="Research paper thumbnail of Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21205120/Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs">Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs</a></div><div class="wp-workCard_item"><span>Asian Journal of Biochemistry</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extrac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg -1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p&amp;lt;0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg -1 group showing significant difference compared to lower-dose and saline groups (p&amp;lt;0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21205120"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21205120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205120]").text(description); $(".js-view-count[data-work-id=21205120]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21205120']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21205120, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21205120]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21205120,"title":"Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs","translated_title":"","metadata":{"abstract":"ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg -1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p\u0026amp;lt;0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg -1 group showing significant difference compared to lower-dose and saline groups (p\u0026amp;lt;0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Asian Journal of Biochemistry"},"translated_abstract":"ABSTRACT The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg -1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p\u0026amp;lt;0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg -1 group showing significant difference compared to lower-dose and saline groups (p\u0026amp;lt;0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.","internal_url":"https://www.academia.edu/21205120/Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs","translated_internal_url":"","created_at":"2016-01-29T22:58:43.208-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42358348,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14202416,"work_id":21205120,"tagging_user_id":42358348,"tagged_user_id":null,"co_author_invite_id":3300102,"email":"3***1@uwc.ac.za","display_order":0,"name":"Habeeb Bankole","title":"Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs"},{"id":14202419,"work_id":21205120,"tagging_user_id":42358348,"tagged_user_id":12445258,"co_author_invite_id":null,"email":"o***u@lasu.edu.ng","affiliation":"Lagos State University, Lagos, Nigeria","display_order":4194304,"name":"Oluwatosin Adu","title":"Biochemical Effect of Ethanolic Extract of Phyllanthus amarus (Euphorbiaceae) on Plasma Nitric Oxide and Penile Cyclic Guanosine Monophosphate (cGMP) in Mature Male Guinea Pigs"}],"downloadable_attachments":[],"slug":"Biochemical_Effect_of_Ethanolic_Extract_of_Phyllanthus_amarus_Euphorbiaceae_on_Plasma_Nitric_Oxide_and_Penile_Cyclic_Guanosine_Monophosphate_cGMP_in_Mature_Male_Guinea_Pigs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42358348,"first_name":"Azeez","middle_initials":"","last_name":"Fatai","page_name":"Fatai","domain_name":"independent","created_at":"2016-01-29T22:58:06.405-08:00","display_name":"Azeez Fatai","url":"https://independent.academia.edu/Fatai"},"attachments":[],"research_interests":[{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15808408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15808408/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste"><img alt="Research paper thumbnail of Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste" class="work-thumbnail" src="https://attachments.academia-assets.com/41205946/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15808408/Isolation_and_partial_characterization_of_a_protease_enzyme_from_Thaumatococcus_daniellii_waste">Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://lasunigeria.academia.edu/BabajideElemo">Babajide Elemo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ORaimi">Olawale Raimi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/Fatai">Azeez Fatai</a></span></div><div class="wp-workCard_item"><span>AFRICAN JOURNAL OF BIOTECHNOLOGY</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d620b3390bfac8bc93ae91d3a2c97d04" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41205946,"asset_id":15808408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41205946/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15808408"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15808408"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15808408; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15808408]").text(description); $(".js-view-count[data-work-id=15808408]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15808408; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15808408']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15808408, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d620b3390bfac8bc93ae91d3a2c97d04" } } $('.js-work-strip[data-work-id=15808408]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15808408,"title":"Isolation and partial characterization of a protease enzyme from Thaumatococcus daniellii waste","translated_title":"","metadata":{"abstract":"A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. The enzyme had an optimum temperature of 35掳C and functioned best at pH 7.0 with some residual activity at alkaline pH.","ai_title_tag":"Characterization of a Protease from Thaumatococcus daniellii Waste","publication_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY"},"translated_abstract":"A protease enzyme was isolated and partially purified from the pulp of Thaumatococcus daniellii fruit by gel filtration on sephadex G-75 followed by ion-exchange column chromatography on DEAEcellulose. The enzyme showed a specific activity of 4.75 脳 10-1 unit/mg protein and 6.93 脳 10-1 unit/mg protein, respectively after each purification procedure. The purified enzyme had a Km and Vmax of 2.0 脳 10-4 M and 1.53 mol/min, respectively, using casein as substrate. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15808416"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15808416/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_"><img alt="Research paper thumbnail of Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)" class="work-thumbnail" src="https://attachments.academia-assets.com/41205953/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15808416/Characterization_of_alkaline_alkaline_phosphatase_from_gaint_African_snail_Archachatina_marginata_">Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ORaimi">Olawale Raimi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/Fatai">Azeez Fatai</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digesti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. ALP activity was found to be highest in the digestive gland. The K m and V max were estimated to be 0.10 mM and 1.37 碌mol/min/ml respectively. The pH optimum was found to be 10 and enzyme was stable at 60 掳C for 15 min. Metals (MgCl 2 , MnCl 2 , CaCl 2) produced an unstable inhibitory effect on the enzyme but the effect was stronger at concentration beyond 1.0 mg/ml. Other inhibitors such as EDTA, 芒-mercaptoethanol and fluoro-oxalate inhibited the enzyme at high concentrations. The highest activity of the enzyme in the digestive gland of the snail in this study suggests that most of the organic phosphates in the species are hydrolyzed principally in this tissue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a8b10801862df9b21cf84729721e86ac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41205953,"asset_id":15808416,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41205953/download_file?st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&st=MTczMzI1MzQ1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15808416"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15808416"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15808416; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15808416]").text(description); $(".js-view-count[data-work-id=15808416]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15808416; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15808416']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15808416, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a8b10801862df9b21cf84729721e86ac" } } $('.js-work-strip[data-work-id=15808416]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15808416,"title":"Characterization of alkaline alkaline phosphatase from gaint African snail (Archachatina marginata)","translated_title":"","metadata":{"abstract":"Alkaline Phosphatase (ALP) activity was determined in different snail tissue homogenates (digestive gland, gonad and stomach) and the heamolymph. 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