CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Jessica Wagenseil | Washington University in St. Louis - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="qY22ep8609n0UnnjCBJUX-pPjZxjfFUDIAMpqoK49YdAUD8KBYeFGyzCdGomRt2IfwlPWJ-TAs4fx7PlhTkn_Q" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-bfbac2a470372e2f3a6661a65fa7ff0a0fbf7aa32534d9a831d683d2a6f9e01b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="jessica wagenseil" /> <meta name="description" content="Jessica Wagenseil, Washington University in St. Louis: 13 Followers, 2 Following, 34 Research papers. Research interests: Clinical Microbiology, Research…" /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'b092bf3a3df71cf13feee7c143e83a57eb6b94fb'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14016,"monthly_visitors":"99 million","monthly_visitor_count":99567017,"monthly_visitor_count_in_millions":99,"user_count":283018322,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1739817888000); window.Aedu.timeDifference = new Date().getTime() - 1739817888000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-40698df34f913bd208bb70f09d2feb7c6286046250be17a4db35bba2c08b0e2f.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-a22f75d8519394c21253dae46c8c5d60ad36ea68c7d494347ec64229d8c1cf85.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-5708a105dd66b4c7d0ef30b7c094b1048423f0042bd2a7b123f2d99ee3cf46d9.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://wustl.academia.edu/JessicaWagenseil" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-c0b60aedadfb9d46b698730fbbcb2e70645c886b405d825adeba3a031c02455d.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil","photo":"/images/s65_no_pic.png","has_photo":false,"department":{"id":1691407,"name":"Mechanical Engineering and Materials Science","url":"https://wustl.academia.edu/Departments/Mechanical_Engineering_and_Materials_Science/Documents","university":{"id":972,"name":"Washington University in St. Louis","url":"https://wustl.academia.edu/"}},"position":"Faculty Member","position_id":1,"is_analytics_public":false,"interests":[{"id":43666,"name":"Clinical Microbiology","url":"https://www.academia.edu/Documents/in/Clinical_Microbiology"},{"id":573442,"name":"Research Journal of Medical Sciences","url":"https://www.academia.edu/Documents/in/Research_Journal_of_Medical_Sciences"},{"id":79394,"name":"Gravity","url":"https://www.academia.edu/Documents/in/Gravity"},{"id":25836,"name":"Music Perception","url":"https://www.academia.edu/Documents/in/Music_Perception"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://wustl.academia.edu/JessicaWagenseil","location":"/JessicaWagenseil","scheme":"https","host":"wustl.academia.edu","port":null,"pathname":"/JessicaWagenseil","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-2e4509e0-69a9-422a-a242-c395c4f45f31"></div> <div id="ProfileCheckPaperUpdate-react-component-2e4509e0-69a9-422a-a242-c395c4f45f31"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Jessica Wagenseil</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://wustl.academia.edu/">Washington University in St. Louis</a>, <a class="u-tcGrayDarker" href="https://wustl.academia.edu/Departments/Mechanical_Engineering_and_Materials_Science/Documents">Mechanical Engineering and Materials Science</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Jessica" data-follow-user-id="35431762" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="35431762"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">13</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">2</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">2</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/JessicaWagenseil/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://mq.academia.edu/AlbertoAvolio"><img class="profile-avatar u-positionAbsolute" alt="Alberto Avolio" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/639740/220084/257244/s200_alberto.avolio.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://mq.academia.edu/AlbertoAvolio">Alberto Avolio</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Macquarie University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://johnshopkins.academia.edu/TheodoreAbraham"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://johnshopkins.academia.edu/TheodoreAbraham">Theodore Abraham</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Johns Hopkins University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://cnr-it.academia.edu/marcellomancini"><img class="profile-avatar u-positionAbsolute" alt="marcello mancini" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/23714857/28150605/26368356/s200_marcello.mancini.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://cnr-it.academia.edu/marcellomancini">marcello mancini</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Consiglio Nazionale delle Ricerche (CNR)</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://miami.academia.edu/SKulandavelu"><img class="profile-avatar u-positionAbsolute" alt="S. Kulandavelu" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/36374933/10460636/11672046/s200_s..kulandavelu.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://miami.academia.edu/SKulandavelu">S. Kulandavelu</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Miami</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/LisandradeCastroBr%C3%A1s"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/LisandradeCastroBr%C3%A1s">Lisandra de Castro Brás</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/JustinCarlManuel"><img class="profile-avatar u-positionAbsolute" alt="Justin Carl Manuel" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/268987828/119623789/108943648/s200_justin_carl.manuel.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/JustinCarlManuel">Justin Carl Manuel</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/StevenScharf"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/StevenScharf">Steven Scharf</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/ColinPhoon"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/ColinPhoon">Colin Phoon</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/kylepowers2"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/kylepowers2">kyle powers</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/RonaldEmeson"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/RonaldEmeson">Ronald Emeson</a></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35431762" href="https://www.academia.edu/Documents/in/Clinical_Microbiology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://wustl.academia.edu/JessicaWagenseil","location":"/JessicaWagenseil","scheme":"https","host":"wustl.academia.edu","port":null,"pathname":"/JessicaWagenseil","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Clinical Microbiology"]}" data-trace="false" data-dom-id="Pill-react-component-90a590a0-4ba3-494e-8c09-3435f540c3b9"></div> <div id="Pill-react-component-90a590a0-4ba3-494e-8c09-3435f540c3b9"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35431762" href="https://www.academia.edu/Documents/in/Research_Journal_of_Medical_Sciences"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Research Journal of Medical Sciences"]}" data-trace="false" data-dom-id="Pill-react-component-12ca4af3-94bb-44e1-bc16-7ac492a4e333"></div> <div id="Pill-react-component-12ca4af3-94bb-44e1-bc16-7ac492a4e333"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35431762" href="https://www.academia.edu/Documents/in/Gravity"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Gravity"]}" data-trace="false" data-dom-id="Pill-react-component-1e1fefae-0321-4617-b842-3224d3d095bb"></div> <div id="Pill-react-component-1e1fefae-0321-4617-b842-3224d3d095bb"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35431762" href="https://www.academia.edu/Documents/in/Music_Perception"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Music Perception"]}" data-trace="false" data-dom-id="Pill-react-component-a876a822-15bb-4080-b05e-546f5ba4dd56"></div> <div id="Pill-react-component-a876a822-15bb-4080-b05e-546f5ba4dd56"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Jessica Wagenseil</h3></div><div class="js-work-strip profile--work_container" data-work-id="106404884"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106404884/Measuring_left_ventricular_pressure_in_late_embryonic_and_neonatal_mice"><img alt="Research paper thumbnail of Measuring left ventricular pressure in late embryonic and neonatal mice" class="work-thumbnail" src="https://attachments.academia-assets.com/105611417/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106404884/Measuring_left_ventricular_pressure_in_late_embryonic_and_neonatal_mice">Measuring left ventricular pressure in late embryonic and neonatal mice</a></div><div class="wp-workCard_item"><span>Journal of visualized experiments : JoVE</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Blood pressure increases significantly during embryonic and postnatal development in vertebrate a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Blood pressure increases significantly during embryonic and postnatal development in vertebrate animals. In the mouse, blood flow is first detectable around embryonic day (E) 8.5 1. Systolic left ventricular (LV) pressure is 2 mmHg at E9.5 and 11 mmHg at E14.5 2. At these midembryonic stages, the LV is clearly visible through the chest wall for invasive pressure measurements because the ribs and skin are not fully developed. Between E14.5 and birth (approximately E21) imaging methods must be used to view the LV. After birth, mean arterial pressure increases from 30-70 mmHg from postnatal day (P) 2-35 3. Beyond P20, arterial pressure can be measured with solid-state catheters (i.e. Millar or Scisense). Before P20, these catheters are too big for developing mouse arteries and arterial pressure must be measured with custom pulled plastic catheters attached to fluid-filled pressure transducers 3 or glass micropipettes attached to servo null pressure transducers 4. Our recent work has shown that the greatest increase in blood pressure occurs during the late embryonic to early postnatal period in mice 5-7. This large increase in blood pressure may influence smooth muscle cell (SMC) phenotype in developing arteries and trigger important mechanotransduction events. In human disease, where the mechanical properties of developing arteries are compromised by defects in extracellular matrix proteins (i.e. Marfan's Syndrome 8 and Supravalvular Aortic Stenosis 9</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d94ecb5f1bcd895a34aaa272348acb39" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105611417,"asset_id":106404884,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105611417/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106404884"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106404884"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106404884; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106404884]").text(description); $(".js-view-count[data-work-id=106404884]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106404884; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106404884']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d94ecb5f1bcd895a34aaa272348acb39" } } $('.js-work-strip[data-work-id=106404884]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106404884,"title":"Measuring left ventricular pressure in late embryonic and neonatal mice","internal_url":"https://www.academia.edu/106404884/Measuring_left_ventricular_pressure_in_late_embryonic_and_neonatal_mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":105611417,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105611417/thumbnails/1.jpg","file_name":"pmc3376943.pdf","download_url":"https://www.academia.edu/attachments/105611417/download_file","bulk_download_file_name":"Measuring_left_ventricular_pressure_in_l.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105611417/pmc3376943-libre.pdf?1694224836=\u0026response-content-disposition=attachment%3B+filename%3DMeasuring_left_ventricular_pressure_in_l.pdf\u0026Expires=1739821487\u0026Signature=ZTct-GqrJtijpew4CPuh-nCvbG8C5qNjfG3reRO5vxBP~La7wTHQkEQumj76wJWTdr0HQCyL-XUSkSZ5DBthu19VbsPecZWmrMEgKsrXZR-Q3QKqeNfIn5io2Gvy1zCQpk3wLIp2-YzaMT~KXTN7UCAxt~prmhHpjt1FsLNIhkhjprnf5VjoXNK2QuaWjrnWn9HwZfoxFgXksy0r029PpIP3l9lWp-UgkKWdQISZfgrl2msi7EyyZscHNYpFVeMbrNY16~KEiz~y6Xr5aYxIf5V4T6YC7M3a8OmWFOKxbTGmnwUeTW6krvfplvWNNHohtMJR4zrU90-vQlUB9fLVpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="106404883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106404883/Elastin_arterial_mechanics_and_cardiovascular_disease"><img alt="Research paper thumbnail of Elastin, arterial mechanics, and cardiovascular disease" class="work-thumbnail" src="https://attachments.academia-assets.com/105611415/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106404883/Elastin_arterial_mechanics_and_cardiovascular_disease">Elastin, arterial mechanics, and cardiovascular disease</a></div><div class="wp-workCard_item"><span>American journal of physiology. Heart and circulatory physiology</span><span>, Jan 6, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Large, elastic arteries are composed of cells and a specialized extracellular matrix that provide...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on the heart and dampens pulsatile flow in distal arteries. We summarize elastin protein biochemistry, self-association behavior, crosslinking process, and multi-step elastic fiber assembly that provide large arteries with their unique mechanical properties. We present measures of passive arterial mechanics that depend on elastic fiber amounts and integrity such as the Windkessel effect, structural and material stiffness, and energy storage. We discuss supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa-1 (ADCL1), which are genetic disorders caused by mutations in the elastin gene. We present mouse models of SVAS, ADCL1, and graded elastin amounts that have been invaluable for understanding the role of elastin in arterial mechanics an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b481da691b79c919b72dd2088119d323" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105611415,"asset_id":106404883,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105611415/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106404883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106404883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106404883; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106404883]").text(description); $(".js-view-count[data-work-id=106404883]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106404883; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106404883']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b481da691b79c919b72dd2088119d323" } } $('.js-work-strip[data-work-id=106404883]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106404883,"title":"Elastin, arterial mechanics, and cardiovascular disease","internal_url":"https://www.academia.edu/106404883/Elastin_arterial_mechanics_and_cardiovascular_disease","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":105611415,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105611415/thumbnails/1.jpg","file_name":"Cocciolone_2018_AJP_Heart_Review-1xi2ctk.pdf","download_url":"https://www.academia.edu/attachments/105611415/download_file","bulk_download_file_name":"Elastin_arterial_mechanics_and_cardiovas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105611415/Cocciolone_2018_AJP_Heart_Review-1xi2ctk-libre.pdf?1694224843=\u0026response-content-disposition=attachment%3B+filename%3DElastin_arterial_mechanics_and_cardiovas.pdf\u0026Expires=1739821487\u0026Signature=gXICt9FuXEL~FkExnY46FH6SxgBZy03zG7HQfuWtP4xFd4wpdywZKCOJPwz-2NdUIgNIwXQtd8crJi78wXyd8y6ii9DwrNY7wJiUAz3-Ty7C4pVpFLPMYh13cWFrcEhcjzJDu16hkhtDYS~Jc1xf7L1BxI1w2as3CRXht-nPygWcIMV-tNujl4pI8FQQr6KegEXvesut3dsWMsw7-XjTzKhxEoz7chWASfa6LUT0VlXMFA2Hp-RbasMX6SCF1m4ig~WB2494ugkrLE~vyq0EuF8ykFKoTfmALP014NYrzh6RqSsmV6vyDMJIIYfoYLQcndRCul748KGzU3JWE92fRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404852"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87404852/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices"><img alt="Research paper thumbnail of One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87404852/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices">One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404852"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404852"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404852; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404852]").text(description); $(".js-view-count[data-work-id=87404852]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404852; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404852']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87404852]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404852,"title":"One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices","internal_url":"https://www.academia.edu/87404852/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404846"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87404846/A_Cell_Based_Constitutive_Relation_for_Bio_Artificial_Tissues"><img alt="Research paper thumbnail of A Cell-Based Constitutive Relation for Bio-Artificial Tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/91621722/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87404846/A_Cell_Based_Constitutive_Relation_for_Bio_Artificial_Tissues">A Cell-Based Constitutive Relation for Bio-Artificial Tissues</a></div><div class="wp-workCard_item"><span>Biophysical Journal</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d05c16e3439c3fd7c598254342e65530" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91621722,"asset_id":87404846,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91621722/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404846"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404846"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404846; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404846]").text(description); $(".js-view-count[data-work-id=87404846]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404846; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404846']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d05c16e3439c3fd7c598254342e65530" } } $('.js-work-strip[data-work-id=87404846]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404846,"title":"A Cell-Based Constitutive Relation for Bio-Artificial Tissues","internal_url":"https://www.academia.edu/87404846/A_Cell_Based_Constitutive_Relation_for_Bio_Artificial_Tissues","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":91621722,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91621722/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/91621722/download_file","bulk_download_file_name":"A_Cell_Based_Constitutive_Relation_for_B.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91621722/pdf-libre.pdf?1664277524=\u0026response-content-disposition=attachment%3B+filename%3DA_Cell_Based_Constitutive_Relation_for_B.pdf\u0026Expires=1739821487\u0026Signature=AfXzuJnsBaKkMCkfa421Cd1vU1G212Q3d6iybUcS03TvDTSVzTKv8aIaYlEEw~R65fEObqHvyMJCCJDxmSBYzbY4~giYJjRhqWzr2MgvZY3316Ne2Tk3kcHRjb65I6BhJx-XLNq-gAS6olZ6HBlyEAtAeTL1v5ywQtVPMxibIOpLoQPqijqt864biwQGNqpOjN2DqTIPia031Rm4iY0wnThQH6c0GmmL9oZlacCh2CBaUsQCXw-aIueY8RLuhtrOOcxflEtsQe0hXZoaXkHRF113MfRPgarC9a8q50jjyr9wuo-NSzH9CRMHqnqNJGQ0nnXeKX-iF2vrMH7i~naB-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404841"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87404841/Cell_Orientation_Influences_the_Biaxial_Mechanical_Properties_of_Fibroblast_Populated_Collagen_Vessels"><img alt="Research paper thumbnail of Cell Orientation Influences the Biaxial Mechanical Properties of Fibroblast Populated Collagen Vessels" class="work-thumbnail" src="https://attachments.academia-assets.com/91621716/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87404841/Cell_Orientation_Influences_the_Biaxial_Mechanical_Properties_of_Fibroblast_Populated_Collagen_Vessels">Cell Orientation Influences the Biaxial Mechanical Properties of Fibroblast Populated Collagen Vessels</a></div><div class="wp-workCard_item"><span>Annals of Biomedical Engineering</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="33140b193a1b2da66f14b4871c0e1fe4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91621716,"asset_id":87404841,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91621716/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404841"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404841"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404841; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404841]").text(description); $(".js-view-count[data-work-id=87404841]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404841; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404841']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "33140b193a1b2da66f14b4871c0e1fe4" } } $('.js-work-strip[data-work-id=87404841]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404841,"title":"Cell Orientation Influences the Biaxial Mechanical Properties of Fibroblast Populated Collagen Vessels","internal_url":"https://www.academia.edu/87404841/Cell_Orientation_Influences_the_Biaxial_Mechanical_Properties_of_Fibroblast_Populated_Collagen_Vessels","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":91621716,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91621716/thumbnails/1.jpg","file_name":"0203.pdf","download_url":"https://www.academia.edu/attachments/91621716/download_file","bulk_download_file_name":"Cell_Orientation_Influences_the_Biaxial.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91621716/0203-libre.pdf?1664277518=\u0026response-content-disposition=attachment%3B+filename%3DCell_Orientation_Influences_the_Biaxial.pdf\u0026Expires=1739821487\u0026Signature=YrOAfcUjDIjVA1Ny6TqqMItrv1SyTHcHt5cf2DftoPHqFAipfypOQR--0ws5IWGrNsdC1G~3D3aE6pZa~VNNMvyZmHuNMWzLVGwq4WBNMTsIHTc-WNuwXI2OLpQ-IHDxDsqTFWysFOVnY4Is-H3Cz4l0t26kYlVH68P6aOv-ZrJ3xIDw~GskGaBPQeT9vuQaTmPIpl09upgEzG7BGyJMJIl02OM1UboK-TphfpokYUuuWIKr7IiOi5s5RcFbBuTRBJgdVMk6jOnhdqs25r8IVgkaheshRkR-v1E8CjrhKGenDnhJCPGi3DH03IaajXxQYQNBCnSQ5-VMRvoqZZst-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404753"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87404753/Mechanical_factors_direct_mouse_aortic_remodelling_during_early_maturation"><img alt="Research paper thumbnail of Mechanical factors direct mouse aortic remodelling during early maturation" class="work-thumbnail" src="https://attachments.academia-assets.com/91621596/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87404753/Mechanical_factors_direct_mouse_aortic_remodelling_during_early_maturation">Mechanical factors direct mouse aortic remodelling during early maturation</a></div><div class="wp-workCard_item"><span>Journal of The Royal Society Interface</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Numerous diseases have been linked to genetic mutations that lead to reduced amounts or disorgani...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Numerous diseases have been linked to genetic mutations that lead to reduced amounts or disorganization of arterial elastic fibres. Previous work has shown that mice with reduced amounts of elastin (Eln+/−) are able to live a normal lifespan through cardiovascular adaptations, including changes in haemodynamic stresses, arterial geometry and arterial wall mechanics. It is not known if the timeline and presence of these adaptations are consistent in other mouse models of elastic fibre disease, such as those caused by the absence of fibulin-5 expression (Fbln5−/−). AdultFbln5−/−mice have disorganized elastic fibres, decreased arterial compliance and high blood pressure. We examined mechanical behaviour of the aorta inFbln5−/−mice through early maturation when the elastic fibres are being assembled. We found that the physiologic circumferential stretch, stress and modulus ofFbln5−/−aorta are maintained near wild-type levels. Constitutive modelling suggests that elastin contributions to...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea87a86b9cec7af24e4eb86675918c76" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91621596,"asset_id":87404753,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91621596/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404753"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404753"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404753; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404753]").text(description); $(".js-view-count[data-work-id=87404753]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404753; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404753']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ea87a86b9cec7af24e4eb86675918c76" } } $('.js-work-strip[data-work-id=87404753]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404753,"title":"Mechanical factors direct mouse aortic remodelling during early maturation","internal_url":"https://www.academia.edu/87404753/Mechanical_factors_direct_mouse_aortic_remodelling_during_early_maturation","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":91621596,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91621596/thumbnails/1.jpg","file_name":"rsif.2014.pdf","download_url":"https://www.academia.edu/attachments/91621596/download_file","bulk_download_file_name":"Mechanical_factors_direct_mouse_aortic_r.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91621596/rsif.2014-libre.pdf?1664278921=\u0026response-content-disposition=attachment%3B+filename%3DMechanical_factors_direct_mouse_aortic_r.pdf\u0026Expires=1739821487\u0026Signature=TV~D1~qNm9u~-yMeAjCIHdfyJboVnP2xDaFwZ6~atFzSYUh88StmJGa0Son8kb-ji0d07UVhmZ-qLGMXLX0DMBKXVXfnU2FEyC6rycZgkFirgoVcXS3qYJJer6ifBQkrmFKb3KBKXjYa5D33NB9XdoajjRiBs0DH0hUU8ChseVHIGB2FaD9ByuxHZsCLhOPjJS7r3UekqAf1Z3nZS8mhpF54H0-EVRDLMzhYnZnIIm9p9tOYVCdWfnzdVBtu~GQXAeh07qRqFkaD-sprH0UkzBdNE1a8-G2dQWI4EogimDXwoq3HivxoA86IfQcRAdiZQaCRq7hmI9Dhh2bE~dBPCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80475709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80475709/Crosslinked_elastic_fibers_are_necessary_for_low_energy_loss_in_the_ascending_aorta"><img alt="Research paper thumbnail of Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta" class="work-thumbnail" src="https://attachments.academia-assets.com/86844577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80475709/Crosslinked_elastic_fibers_are_necessary_for_low_energy_loss_in_the_ascending_aorta">Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta</a></div><div class="wp-workCard_item"><span>Journal of Biomechanics</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the large arteries, it is believed that elastin provides the resistance to stretch at low pres...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the large arteries, it is believed that elastin provides the resistance to stretch at low pressure, while collagen provides the resistance to stretch at high pressure. It is also thought that elastin is responsible for the low energy loss observed with cyclic loading. These tenets are supported through experiments that alter component amounts through protease digestion, vessel remodeling, normal growth, or in different artery types. Genetic engineering provides the opportunity to revisit these tenets through the loss of expression of specific wall components. We used newborn mice lacking elastin (Eln À/À) or two key proteins (lysyl oxidase, Lox À/À , or fibulin-4, Fbln4 À/À) that are necessary for the assembly of mechanicallyfunctional elastic fibers to investigate the contributions of elastic fibers to large artery mechanics. We determined component content and organization and quantified the nonlinear and viscoelastic mechanical behavior of Eln À/À , Lox À/À , and Fbln4 À/À ascending aorta and their respective controls. We confirmed that the lack of elastin, fibulin-4, or lysyl oxidase leads to absent or highly fragmented elastic fibers in the aortic wall and a 56-97% decrease in crosslinked elastin amounts. We found that the resistance to stretch at low pressure is decreased only in Eln À/À aorta, confirming the role of elastin in the nonlinear mechanical behavior of the aortic wall. Dissipated energy with cyclic loading and unloading is increased 53-387% in Eln À/À , Lox À/À , and Fbln4 À/À aorta, indicating that not only elastin, but properly assembled and crosslinked elastic fibers, are necessary for low energy loss in the aorta.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3d215bf70c3de0fb18c441395a571845" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86844577,"asset_id":80475709,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86844577/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80475709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80475709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80475709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80475709]").text(description); $(".js-view-count[data-work-id=80475709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80475709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80475709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3d215bf70c3de0fb18c441395a571845" } } $('.js-work-strip[data-work-id=80475709]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80475709,"title":"Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta","internal_url":"https://www.academia.edu/80475709/Crosslinked_elastic_fibers_are_necessary_for_low_energy_loss_in_the_ascending_aorta","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":86844577,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86844577/thumbnails/1.jpg","file_name":"kim_2017_eln_fbln4_lox_mechanics-1fbw7ob.pdf","download_url":"https://www.academia.edu/attachments/86844577/download_file","bulk_download_file_name":"Crosslinked_elastic_fibers_are_necessary.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86844577/kim_2017_eln_fbln4_lox_mechanics-1fbw7ob-libre.pdf?1654109616=\u0026response-content-disposition=attachment%3B+filename%3DCrosslinked_elastic_fibers_are_necessary.pdf\u0026Expires=1739821487\u0026Signature=NvICFUxogb19slsdJC2tKcNHJTCL57Xnx86UaK8ivtMIF1pOwWiOS3hgVAtMnFahJq5v8nuEjb-mMLxzgAzYysVMkrgCJl7klPa1v1t34JLS96SyJVzorDbknNoImxDCNbtOPZKBi0RskdBcGWVvuxyh0oXSUiFk2KgH46gDFeMPFUZI90Nf5BJ5MqSrr~ykVftcVGvD81QSJvI14ANFI9F4gg0FveAbG7aMH1XMdoe7nqMNKsC8UBj1YPDewVqlqRyMnj731TbAO04teWzNoOpPO~31ahOrdg~4BhYaLyURXORnrdRS3ZweEet~rUGcHFpzVzvFc-BS73IE-puyJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323216"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323216/Angiotensin_Converting_Enzyme_Induced_Activation_of_Local_Angiotensin_Signaling_Is_Required_for_Ascending_Aortic_Aneurysms_in_Fibulin_4_Deficient_Mice"><img alt="Research paper thumbnail of Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522485/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323216/Angiotensin_Converting_Enzyme_Induced_Activation_of_Local_Angiotensin_Signaling_Is_Required_for_Ascending_Aortic_Aneurysms_in_Fibulin_4_Deficient_Mice">Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice</a></div><div class="wp-workCard_item"><span>Science Translational Medicine</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fef4234805844bfb0b91ead35dc0a37b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522485,"asset_id":16323216,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522485/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323216"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323216"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323216; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323216]").text(description); $(".js-view-count[data-work-id=16323216]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323216; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323216']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fef4234805844bfb0b91ead35dc0a37b" } } $('.js-work-strip[data-work-id=16323216]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323216,"title":"Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice","internal_url":"https://www.academia.edu/16323216/Angiotensin_Converting_Enzyme_Induced_Activation_of_Local_Angiotensin_Signaling_Is_Required_for_Ascending_Aortic_Aneurysms_in_Fibulin_4_Deficient_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522485,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522485/thumbnails/1.jpg","file_name":"Angiotensin-Converting_Enzyme-Induced_Ac20160209-30589-1jriw7x.pdf","download_url":"https://www.academia.edu/attachments/42522485/download_file","bulk_download_file_name":"Angiotensin_Converting_Enzyme_Induced_Ac.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522485/Angiotensin-Converting_Enzyme-Induced_Ac20160209-30589-1jriw7x-libre.pdf?1455071579=\u0026response-content-disposition=attachment%3B+filename%3DAngiotensin_Converting_Enzyme_Induced_Ac.pdf\u0026Expires=1739821487\u0026Signature=CIMX1P5t3lVzjmLfXuUJGB~wzjuXfeWbaPyInAu1w63TwFDLU8IbKySCwegyvLr-k6ExN02uEVSp~EruzUR8HKGocV3wwqa2~o6lcg4Ouu31rRdcKYoV4b-a14iIiB97QrOlay6~hvwRuY7bqGz9ieh39m6lIb9vSBY3Z4tFxPQ5A7Rmc0XYxqUAkGEW7xD34TfgWikVvhrgkKc1BN2sG1gDQ41-SPLPYJ4OXwyAxYutz82rqgl8v~5C7nC3ByKwXfjes9K9DHOFo0UQH2OqZ7xFnmYY~lOmxktKY2H2JuehVBycP1Tcwy-kdbMqAs-Cv5jGQDUA5ykfugP8YpuAyw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323214"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323214/Vascular_Extracellular_Matrix_and_Arterial_Mechanics"><img alt="Research paper thumbnail of Vascular Extracellular Matrix and Arterial Mechanics" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323214/Vascular_Extracellular_Matrix_and_Arterial_Mechanics">Vascular Extracellular Matrix and Arterial Mechanics</a></div><div class="wp-workCard_item"><span>Physiological Reviews</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">An important factor in the transition from an open to a closed circulatory system was a change in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">An important factor in the transition from an open to a closed circulatory system was a change in vessel wall structure and composition that enabled the large arteries to store and release energy during the cardiac cycle. The component of the arterial wall in vertebrates that accounts for these properties is the elastic fiber network organized by medial smooth muscle. Beginning with the onset of pulsatile blood flow in the developing aorta, smooth muscle cells in the vessel wall produce a complex extracellular matrix (ECM) that will ultimately define the mechanical properties that are critical for proper function of the adult vascular system. This review discusses the structural ECM proteins in the vertebrate aortic wall and will explore how the choice of ECM components has changed through evolution as the cardiovascular system became more advanced and pulse pressure increased. By correlating vessel mechanics with physiological blood pressure across animal species and in mice with altered vessel compliance, we show that cardiac and vascular development are physiologically coupled, and we provide evidence for a universal elastic modulus that controls the parameters of ECM deposition in vessel wall development. We also discuss mechanical models that can be used to design better tissue-engineered vessels and to test the efficacy of clinical treatments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323214"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323214"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323214; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323214]").text(description); $(".js-view-count[data-work-id=16323214]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323214; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323214']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323214]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323214,"title":"Vascular Extracellular Matrix and Arterial Mechanics","internal_url":"https://www.academia.edu/16323214/Vascular_Extracellular_Matrix_and_Arterial_Mechanics","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323211"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323211/Cardiovascular_mechanics_in_newborn_ELN_and_mice"><img alt="Research paper thumbnail of Cardiovascular mechanics in newborn ELN+/+, +/− and−/− mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522465/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323211/Cardiovascular_mechanics_in_newborn_ELN_and_mice">Cardiovascular mechanics in newborn ELN+/+, +/− and−/− mice</a></div><div class="wp-workCard_item"><span>Matrix Biology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ELN+/− mice have increased blood pressure, smaller vessels and increased elastic lamellae. ELN−/−...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ELN+/− mice have increased blood pressure, smaller vessels and increased elastic lamellae. ELN−/− mice die soon after birth due to occlusive proliferation of smooth muscle cells (SMCs). In both cases, decreased elastin levels and altered mechanical signals may influence SMC phenotype. We have measured blood pressure, aortic wall structure and aortic mechanical properties of ELN+/+, +/− and−/− mice on postnatal day 0 (P0). Blood pressure in P0 ELN−/− mice is higher than ELN+/+ and +/−. Aortic inner diameter is significantly different between all genotypes, being smallest in ELN−/−, then ELN+/− and largest in ELN+/+. P0 ELN−/− aorta show disorganized, proliferating SMCs at the intimal surface, instead of the circumferentially organized layers seen in ELN+/+. ELN+/− aorta show elastin producing SMCs in the adventitia, instead of collagen producing fibroblasts as in ELN+/+. Adventitial progenitor cells can be stimulated to differentiate into elastin producing myofibroblasts after stretch induced injury. ELN−/− aorta have lower circumferential stresses at similar pressures compared to ELN+/+ and +/−, but almost identical stresses at physiologic pressure. ELN+/− aorta have increased circumferential stretch ratios at similar pressures compared to ELN+/+ and−/−. At P0, the characteristics of ELN−/− and +/− aorta suggest that circumferential stress induces SMCs to proliferate, while circumferential stretch induces progenitor cells to differentiate. This hypothesis will be investigated through similar studies at additional developmental time points.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9af21e7728e4c02c9c24efff1a0cf6b3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522465,"asset_id":16323211,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522465/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323211"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323211"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323211; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323211]").text(description); $(".js-view-count[data-work-id=16323211]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323211; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323211']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9af21e7728e4c02c9c24efff1a0cf6b3" } } $('.js-work-strip[data-work-id=16323211]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323211,"title":"Cardiovascular mechanics in newborn ELN+/+, +/− and−/− mice","internal_url":"https://www.academia.edu/16323211/Cardiovascular_mechanics_in_newborn_ELN_and_mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522465,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522465/thumbnails/1.jpg","file_name":"j.matbio.2008.09.311.pdf20160209-3321-canzo0","download_url":"https://www.academia.edu/attachments/42522465/download_file","bulk_download_file_name":"Cardiovascular_mechanics_in_newborn_ELN.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522465/j.matbio.2008.09.311-libre.pdf20160209-3321-canzo0?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DCardiovascular_mechanics_in_newborn_ELN.pdf\u0026Expires=1739821487\u0026Signature=V1X367Gc0c5TiqgUjllYp8VzNK9bllv~9QnNeVf4sMVp1OOYjY4gIHqqECyo9~detlv6PWUqgLncTBBG0p6YFnFfCmZvLzH76jn2G29kY7hYmZxb5V355ZWbZWdf6nwTw20NCH~yocTsx43WNJmvNcilMnLizZz87qRzfcjTX5IKFzJ-5UTeDNs8MHbidLkt-T9NW6h7F0fHTsWHbAZa43uE4uECkBxqi4dDLXr3TZ08UniqxQEqJTl5oiLYmy0L5GNjc~GaaVmPsijXLVY4th4p9Lcd0NTpZ9oodYQMRUlTQt5WYu4A3~Maa1X2e6B-oPnUU-MUjzrm4Fp3A~s8sQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323208"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323208/Characterization_of_the_C_terminus_of_mature_elastin"><img alt="Research paper thumbnail of Characterization of the C_terminus of mature elastin" class="work-thumbnail" src="https://attachments.academia-assets.com/42522473/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323208/Characterization_of_the_C_terminus_of_mature_elastin">Characterization of the C_terminus of mature elastin</a></div><div class="wp-workCard_item"><span>Matrix Biology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">strips was decreased when compared to WT controls. Although of lesser magnitude than the changes ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">strips was decreased when compared to WT controls. Although of lesser magnitude than the changes in ELN-deficient animals, the findings were none-the-less concordant. Thus, the data indicate that both quantitative and qualitative defects of ELN alter lung mechanical properties in a similar manner.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9d7bab5f4a234c419b5a8ff61d1f5b2e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522473,"asset_id":16323208,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522473/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323208"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323208"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323208; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323208]").text(description); $(".js-view-count[data-work-id=16323208]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323208; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323208']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9d7bab5f4a234c419b5a8ff61d1f5b2e" } } $('.js-work-strip[data-work-id=16323208]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323208,"title":"Characterization of the C_terminus of mature elastin","internal_url":"https://www.academia.edu/16323208/Characterization_of_the_C_terminus_of_mature_elastin","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522473,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522473/thumbnails/1.jpg","file_name":"j.matbio.2006.08.055.pdf20160209-30594-7aqpsr","download_url":"https://www.academia.edu/attachments/42522473/download_file","bulk_download_file_name":"Characterization_of_the_C_terminus_of_ma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522473/j.matbio.2006.08.055-libre.pdf20160209-30594-7aqpsr?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_the_C_terminus_of_ma.pdf\u0026Expires=1739821487\u0026Signature=VgrmvoMM1KDrdoIjr0dyDq~x0ESXOkxbi13rhjHUxRRHNsCrTttMk9xDVd-G6sechJnoNkO0NJxOPi5Sg6SxWvl5jnhh1ntbF5KPp9gqa6C-o05-EOY3ci1RStd1SUK3B5cbxBBOimFKPQoLIwZFp6~1TKIjOLC6wX9aHVTqBFw-CSB2nQRhD~w6nYyjmt0YPfy03gvjhUeEuf4WkDeHxjphWYVuVM~i86rchfMQ-B1nnqRRmr6Yx2bz~f~DEcoh3uVUEZ-vPcxXRVVh5A8Qvg6d6tZg3sjMGumjWfugaXk-~sE1Y-u8K5MzSG-~-hwcIZOMjJxeTxscDR5vNjpolg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323206"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323206/Hypertension_induced_cardiovascular_remodeling_in_ELN_Mice"><img alt="Research paper thumbnail of Hypertension induced cardiovascular remodeling in ELN+/_Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323206/Hypertension_induced_cardiovascular_remodeling_in_ELN_Mice">Hypertension induced cardiovascular remodeling in ELN+/_Mice</a></div><div class="wp-workCard_item"><span>Matrix Biology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">TB pathogenesis is characterized by the development of granulomas, organized aggregates of differ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">TB pathogenesis is characterized by the development of granulomas, organized aggregates of differentiated, infected macrophages. To identify relevant innate immune determinants of granuloma formation, we analyzed host gene expression in zebrafish embryos infected with Mycobacterium marinum (Mm). Mm is a close genetic relative of M. tb, the cause of human TB. Mm infection of zebrafish embryos recapitulates cardinal features of human TB including aggregation of infected macrophages into granulomas. Zebrafish embryos are optically transparent, allowing for in vivo monitoring of host-pathogen interactions. Since only innate immune cells are active during embryonic infection, innate immunity can be studied in isolation. As we have shown that early granuloma formation is enhanced by the mycobacterial virulence determinant RD1, we compared gene expression during infection with wild-type versus RD1 mutant Mm. MMP-9, MMP-13 and TIMP-2 as well as ECM genes were specifically upregulated. MMP-9 is upregulated in macrophages throughout the embryo whereas MMP-13 is upregulated only in epithelioid granuloma macrophages. Ongoing studies using gene-knock out technologies will determine the precise role of individual MMPs in tuberculous granuloma formation and infection outcome. Characterizing the roles of MMPs in early infection will lead to new insights into innate immune responses to mycobacteria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7070e3ebdefc83b754b0c73f42da4fd0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522467,"asset_id":16323206,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522467/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323206"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323206; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323206]").text(description); $(".js-view-count[data-work-id=16323206]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323206; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323206']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7070e3ebdefc83b754b0c73f42da4fd0" } } $('.js-work-strip[data-work-id=16323206]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323206,"title":"Hypertension induced cardiovascular remodeling in ELN+/_Mice","internal_url":"https://www.academia.edu/16323206/Hypertension_induced_cardiovascular_remodeling_in_ELN_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522467/thumbnails/1.jpg","file_name":"j.matbio.2006.08.038.pdf20160209-29783-1a9dhqo","download_url":"https://www.academia.edu/attachments/42522467/download_file","bulk_download_file_name":"Hypertension_induced_cardiovascular_remo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522467/j.matbio.2006.08.038-libre.pdf20160209-29783-1a9dhqo?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DHypertension_induced_cardiovascular_remo.pdf\u0026Expires=1739821487\u0026Signature=PhPSndYNDoCCLxsE6yjdrNa5th~twn5dGgWMM-cy07nmElrvb9Aky3ukx8wVzzNUHlafeC5PI0j8~kfBb-uPRbtRfGDN2L~VMG~1h3PiBeBuyAgKSAq46JVzXGHbM9-TZyeaI~nErsB03YxQygtDQbQvfat1jPkQY3oo89f~IcbnY8CjabNXrEnBNN-wrLpREUXS7~DktNtUS1~43SJHdbTECX~qFZhnFUkwjwuHQWz6RudRZtZWeTLiePvJUEDXMf5vISORWUaT1kv1ooraBaiadmlBtseLcfAXAuMCLAOd9Now0BjINQf20iFcArcy~AbeVNV26~kJFyTIh1g8UA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323204"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323204/Characterization_of_t1_relaxation_and_blood_myocardial_contrast_enhancement_of_NC100150_injection_in_cardiac_MRI"><img alt="Research paper thumbnail of Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323204/Characterization_of_t1_relaxation_and_blood_myocardial_contrast_enhancement_of_NC100150_injection_in_cardiac_MRI">Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI</a></div><div class="wp-workCard_item"><span>Journal of Magnetic Resonance Imaging</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A new ultrasmall superparamagnetic iron oxide (Clariscan; NC100150 Injection) was studied in dome...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A new ultrasmall superparamagnetic iron oxide (Clariscan; NC100150 Injection) was studied in domestic farm pigs. The T1 effects were characterized for blood and myocardium and the blood-myocardial contrast was measured in T1-weighted cine images. The contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) were measured at baseline and contrast doses of 1 and 5 mg Fe/kg body weight (bw) at end diastole and late systole. The T1 values for blood and myocardium were reduced by 97 and 43%, respectively, from baseline to 5 mg Fe/kg bw. The CNR was significantly improved with contrast at end diastole and late systole. The maximum improvement shown was 202% at 5 mg Fe/kg bw in late systole. The percent SNR enhancement was significantly higher in blood than myocardium at late systole. NC100150 Injection is an effective T1 shortening agent and can be used to improve blood-myocardial contrast in cine images of the heart. J. Magn. Reson. Imaging 1999;10:784-789.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323204"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323204"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323204; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323204]").text(description); $(".js-view-count[data-work-id=16323204]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323204; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323204']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323204]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323204,"title":"Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI","internal_url":"https://www.academia.edu/16323204/Characterization_of_t1_relaxation_and_blood_myocardial_contrast_enhancement_of_NC100150_injection_in_cardiac_MRI","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323202"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323202/Elastic_fiber_formation_A_dynamic_view_of_extracellular_matrix_assembly_using_timer_reporters"><img alt="Research paper thumbnail of Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters" class="work-thumbnail" src="https://attachments.academia-assets.com/42522471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323202/Elastic_fiber_formation_A_dynamic_view_of_extracellular_matrix_assembly_using_timer_reporters">Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters</a></div><div class="wp-workCard_item"><span>Journal of Cellular Physiology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To study the dynamics of elastic fiber assembly, mammalian cells were transfected with a cDNA con...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To study the dynamics of elastic fiber assembly, mammalian cells were transfected with a cDNA construct encoding bovine tropoelastin in frame with the Timer reporter. Timer is a derivative of the DsRed fluorescent protein that changes from green to red over time and, hence, can be used to distinguish new from old elastin. Using dynamic imaging microscopy, we found that the first step in elastic fiber formation is the appearance of small cell surface-associated elastin globules that increased in size with time (microassembly). The elastin globules are eventually transferred to pre-existing elastic fibers in the extracellular matrix where they coalesce into larger structures (macroassembly). Mechanical forces associated with cell movement help shape the forming, extracellular elastic fiber network. Time-lapse imaging combined with the use of Timer constructs provides unique tools for studying the temporal and spatial aspects of extracellular matrix formation by live cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="46fe903b9de9dcc379d1967299195c2e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522471,"asset_id":16323202,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323202"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323202"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323202; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323202]").text(description); $(".js-view-count[data-work-id=16323202]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323202; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323202']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "46fe903b9de9dcc379d1967299195c2e" } } $('.js-work-strip[data-work-id=16323202]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323202,"title":"Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters","internal_url":"https://www.academia.edu/16323202/Elastic_fiber_formation_A_dynamic_view_of_extracellular_matrix_assembly_using_timer_reporters","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522471/thumbnails/1.jpg","file_name":"Elastic_fiber_formation_A_dynamic_view_o20160209-27371-1to67g5.pdf","download_url":"https://www.academia.edu/attachments/42522471/download_file","bulk_download_file_name":"Elastic_fiber_formation_A_dynamic_view_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522471/Elastic_fiber_formation_A_dynamic_view_o20160209-27371-1to67g5-libre.pdf?1455071577=\u0026response-content-disposition=attachment%3B+filename%3DElastic_fiber_formation_A_dynamic_view_o.pdf\u0026Expires=1739821487\u0026Signature=BktYy~9ieMmsCmxlqnR7zJDIZW8zqTVL4AtWkALr7yu74JDiOUJbaTLwKy6-OzBeEHXBDD9nzWferdWAwi0mKzZgx4qRre~03E-UI3gU5emU~1GtMj2x184jqNv6E7hxt7EmuMWpZlHsr~wcw4Kdj54iM72vf2arzfxa2DLgC174UOmpL~Ernd9nKRLXHffXEtMZLSjtR1m3SjxbPCXyBqYQ0paeEBikvJ6GEp6fDdUFMITYPOK~cKB0elYF-~08Alin9YSoEHeEiGU5TP27uOOPh8XeZR2LBJUtDcDpkEa8eFJX0qwKXvvB415~RFCJdLJ-zAxYtmP4NwRyN3t9Aw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323200"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323200/The_Effects_of_Elastic_Fiber_Protein_Insufficiency_and_Treatment_on_the_Modulus_of_Arterial_Smooth_Muscle_Cells"><img alt="Research paper thumbnail of The Effects of Elastic Fiber Protein Insufficiency and Treatment on the Modulus of Arterial Smooth Muscle Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323200/The_Effects_of_Elastic_Fiber_Protein_Insufficiency_and_Treatment_on_the_Modulus_of_Arterial_Smooth_Muscle_Cells">The Effects of Elastic Fiber Protein Insufficiency and Treatment on the Modulus of Arterial Smooth Muscle Cells</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elastic fibers are critical for the mechanical function of the large arteries. Mechanical effects...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elastic fibers are critical for the mechanical function of the large arteries. Mechanical effects of elastic fiber protein deficiency have been investigated in whole arteries, but not in isolated smooth muscle cells (SMCs). The elastic moduli of SMCs from elastin (Eln-/-) and fibulin-4 (Fbln4-/-) knockout mice were measured using atomic force microscopy. Compared to control SMCs, the modulus of Eln-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln-/- SMC modulus is rescued by soluble or α elastin treatment. Altered gene expression, specifically of calponin, suggests that SMC phenotypic modulation may be responsible for the modulus changes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323200"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323200"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323200; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323200]").text(description); $(".js-view-count[data-work-id=16323200]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323200; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323200']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323200]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323200,"title":"The Effects of Elastic Fiber Protein Insufficiency and Treatment on the Modulus of Arterial Smooth Muscle Cells","internal_url":"https://www.academia.edu/16323200/The_Effects_of_Elastic_Fiber_Protein_Insufficiency_and_Treatment_on_the_Modulus_of_Arterial_Smooth_Muscle_Cells","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16268475"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16268475/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices"><img alt="Research paper thumbnail of One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices" class="work-thumbnail" src="https://attachments.academia-assets.com/42594447/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16268475/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices">One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://wustl.academia.edu/ElliotElson">Elliot Elson</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RuthOkamoto">Ruth Okamoto</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://wustl.academia.edu/JessicaWagenseil">Jessica Wagenseil</a></span></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d209400ab572244d47e18fa8c6ce998d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42594447,"asset_id":16268475,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42594447/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16268475"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16268475"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16268475; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16268475]").text(description); $(".js-view-count[data-work-id=16268475]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16268475; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16268475']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d209400ab572244d47e18fa8c6ce998d" } } $('.js-work-strip[data-work-id=16268475]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16268475,"title":"One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices","internal_url":"https://www.academia.edu/16268475/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices","owner_id":35360383,"coauthors_can_edit":true,"owner":{"id":35360383,"first_name":"Elliot","middle_initials":null,"last_name":"Elson","page_name":"ElliotElson","domain_name":"wustl","created_at":"2015-09-28T08:18:54.588-07:00","display_name":"Elliot Elson","url":"https://wustl.academia.edu/ElliotElson"},"attachments":[{"id":42594447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42594447/thumbnails/1.jpg","file_name":"One-dimensional_viscoelastic_behavior_of20160211-14533-18unrrm.pdf","download_url":"https://www.academia.edu/attachments/42594447/download_file","bulk_download_file_name":"One_Dimensional_Viscoelastic_Behavior_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42594447/One-dimensional_viscoelastic_behavior_of20160211-14533-18unrrm-libre.pdf?1455237962=\u0026response-content-disposition=attachment%3B+filename%3DOne_Dimensional_Viscoelastic_Behavior_of.pdf\u0026Expires=1739821487\u0026Signature=KuMoG30ERxh9tiKBte9CBTLXzz3QO2xMkHpyod81Q3MaPHa00h5WhNgPL0qSkC3gzo7BCAcZzIY0FSD~yLwPY~diZtmsx-~MwoVWkj1ay5nBwN46g5UH9xtuW6BRMRmXWPw3tuh~c0h5hziv2ivvKOe2IZWe8vCCDIIzl0Ytei4rqlGawnJI9~Otds2OKUXUfZuFKjN5iVjPMJ2veRS-elxXk3vV1Kl5GfHwzhlw0dKhFasC77NucwEbU~4093MkzU9bf6RItLQIF75I9cRLnkpHelFxbhsruGeJw7gLTbot~Fk4J-wR9HixgWbdJ94nK92jev6LTAKG0DcT4DqlMA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323196/Effect_of_Storage_Duration_on_the_Mechanical_Behavior_of_Mouse_Carotid_Artery"><img alt="Research paper thumbnail of Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery" class="work-thumbnail" src="https://attachments.academia-assets.com/42522474/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323196/Effect_of_Storage_Duration_on_the_Mechanical_Behavior_of_Mouse_Carotid_Artery">Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Determining arterial mechanical properties is important for understanding the work done by the he...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Determining arterial mechanical properties is important for understanding the work done by the heart and how it changes with cardiovascular disease. Ex vivo tests are necessary to apply various loads to the artery and obtain data to model and predict the behavior under any load. Most ex vivo tests are performed within 24 hours of dissection, so the tissue is still "alive". For large elastic arteries, however, the passive mechanical behavior is attributed mostly to the very stable proteins, elastin and collagen. If the testing equipment fails, is in use, or is located at another facility, it would be useful to store the vessels and postpone the tests until the equipment is available. The goal of this study is to determine the effects of storage time on the mechanical behavior of the common carotid artery from adult mice. Each artery was tested after storage for 1-28 days in physiologic saline at 4°C. There were no significant effects of storage time on the arterial diameter or force at each pressure, but there were significant effects on the stretch ratio and stress at each pressure. The significant effects on the stretch ratio and stress were due to decreases in the unloaded dimensions with storage time, when measured from cut arterial rings. When the unloaded dimensions were measured instead from histology sections, there were no significant changes with storage time. We conclude that histology sections yield a more consistent measurement of the unloaded dimensions and that there are no significant changes in the mechanical behavior of mouse carotid artery with storage up to 28 days.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f9895c3f09e22aae435629e4ce68f980" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522474,"asset_id":16323196,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522474/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323196"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323196"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323196; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323196]").text(description); $(".js-view-count[data-work-id=16323196]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323196; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323196']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f9895c3f09e22aae435629e4ce68f980" } } $('.js-work-strip[data-work-id=16323196]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323196,"title":"Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery","internal_url":"https://www.academia.edu/16323196/Effect_of_Storage_Duration_on_the_Mechanical_Behavior_of_Mouse_Carotid_Artery","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522474,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522474/thumbnails/1.jpg","file_name":"Effect_of_storage_duration_on_the_mechan20160209-27376-j51q79.pdf","download_url":"https://www.academia.edu/attachments/42522474/download_file","bulk_download_file_name":"Effect_of_Storage_Duration_on_the_Mechan.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522474/Effect_of_storage_duration_on_the_mechan20160209-27376-j51q79-libre.pdf?1455071578=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Storage_Duration_on_the_Mechan.pdf\u0026Expires=1739821487\u0026Signature=HfNrRVJakoh9iZR~2PMGpU-kA4sleyXBI60dMMcujRXZn1I2YIMr8-MDFysj7xTHila~zDWOaWMNauWiWr7qRZ6lQU9KkXgBvMeqPaCzZ4IteAlclwNFjkbSH-iFCrTuu91wdjXfUIh5PmJ7cOHajbxVu0hiOUvNbmTOQgMvRdqQJxPwVjMyEux2YwmmAp7YkqCKHDldh62fLfSVe9PzRS23QVOeTaHVTcWlPZSHMb47r8KG3BZMsoOPmcQv3Gu6eTuWsVaQ1U5SRixh14AdokyeRPbDHfmTd2t8dtQ80epXTzO0918Qm4~jTlFxxWEivN8Jrj1lg0KQaaJJ~IvUsA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323194/Murrays_Law_in_Elastin_Haploinsufficient_Eln_and_Wild_Type_WT_Mice"><img alt="Research paper thumbnail of Murray's Law in Elastin Haploinsufficient ( Eln+/− ) and Wild-Type (WT) Mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323194/Murrays_Law_in_Elastin_Haploinsufficient_Eln_and_Wild_Type_WT_Mice">Murray's Law in Elastin Haploinsufficient ( Eln+/− ) and Wild-Type (WT) Mice</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Using either the principle of minimum energy or constant shear stress, a relation can be derived ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Using either the principle of minimum energy or constant shear stress, a relation can be derived that predicts the diameters of branching vessels at a bifurcation. This relation, known as Murray&amp;amp;amp;#39;s Law, has been shown to predict vessel diameters in a variety of cardiovascular systems from adult humans to developing chicks. The goal of this study is to investigate Murray&amp;amp;amp;#39;s Law in vessels from mice that are haploinsufficient for the elastin protein (Eln+/-). Elastin is one of the major proteins in the blood vessel wall and is organized in concentric rings, known as lamellae, with smooth muscle cells (SMCs) around the vessel lumen. Eln+/- mice have an increased number of lamellae, as well as smaller, thinner vessels. It is possible that due to decreased amounts of elastin available for vessel wall remodeling during development and in adulthood, Eln+/- vessels would not follow Murray&amp;amp;amp;#39;s Law. We examined vessel bifurcations in six different physiologic regions, including the brain, heart, epidermis, ceocum (or cecum), testes, and intestines, in Eln+/- mice and wild-type (WT) littermates. All vessels were between 40 and 300 μm in diameter. We found that the diameters of both Eln+/- and WT vessels have an average of 13% error from the diameters predicted by Murray&amp;amp;amp;#39;s Law, with no significant differences between genotypes or physiologic regions. The data suggest that vessels are optimized to follow Murray&amp;amp;amp;#39;s Law, despite limitations on the proteins available for growth and remodeling of the vessel wall.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323194]").text(description); $(".js-view-count[data-work-id=16323194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323194,"title":"Murray's Law in Elastin Haploinsufficient ( Eln+/− ) and Wild-Type (WT) Mice","internal_url":"https://www.academia.edu/16323194/Murrays_Law_in_Elastin_Haploinsufficient_Eln_and_Wild_Type_WT_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323192/Alternative_Splicing_and_Tissue_specific_Elastin_Misassembly_Act_as_Biological_Modifiers_of_Human_Elastin_Gene_Frameshift_Mutations_Associated_with_Dominant_Cutis_Laxa"><img alt="Research paper thumbnail of Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa" class="work-thumbnail" src="https://attachments.academia-assets.com/42522518/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323192/Alternative_Splicing_and_Tissue_specific_Elastin_Misassembly_Act_as_Biological_Modifiers_of_Human_Elastin_Gene_Frameshift_Mutations_Associated_with_Dominant_Cutis_Laxa">Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa</a></div><div class="wp-workCard_item"><span>Journal of Biological Chemistry</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: A humanized mouse was developed to study elastin assembly and the pathogenesis of cut...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: A humanized mouse was developed to study elastin assembly and the pathogenesis of cutis laxa. Results: Mutant transcripts incorporate into elastic fibers of skin and lung with adverse effects but not aorta. Conclusion: Elastin frameshift mutations alter elastin assembly domains. Significance: The mechanism of elastic fiber assembly may not be the same in all tissues.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d4851798b739bdc447387a7ad677b4f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522518,"asset_id":16323192,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522518/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323192]").text(description); $(".js-view-count[data-work-id=16323192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d4851798b739bdc447387a7ad677b4f3" } } $('.js-work-strip[data-work-id=16323192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323192,"title":"Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa","internal_url":"https://www.academia.edu/16323192/Alternative_Splicing_and_Tissue_specific_Elastin_Misassembly_Act_as_Biological_Modifiers_of_Human_Elastin_Gene_Frameshift_Mutations_Associated_with_Dominant_Cutis_Laxa","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522518,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522518/thumbnails/1.jpg","file_name":"Alternative_splicing_and_tissue-specific20160209-20574-1425yex.pdf","download_url":"https://www.academia.edu/attachments/42522518/download_file","bulk_download_file_name":"Alternative_Splicing_and_Tissue_specific.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522518/Alternative_splicing_and_tissue-specific20160209-20574-1425yex-libre.pdf?1455071575=\u0026response-content-disposition=attachment%3B+filename%3DAlternative_Splicing_and_Tissue_specific.pdf\u0026Expires=1739821488\u0026Signature=Y2fOV4BCKjn6RKwrZix-ykiwrsPzDv~wkc5VYcm3zZUYbGt97qX4eO1r-dOTpN9t9vGLXYFSYMLfbLN4t2JRyTXl5cL2FOC-oPjdkJXQql0Km~sk~ANHzdp6pp~s~JHAc4wtVcsWAdetuJbGCJTvYoAliDpF-d6GuUH7tAaBH65MN70upCburJqI1QQViNuKpv4TV4~wghwkYWeTPe4DUcW3oVVZ~fbC2Hvgudjr0hLcYITvpVteFvxVbLx3ZqcFZm5N3DI0tSfIv8arU5pZ2tAD32ZxKdNTUObYGzie8lOu0h0NqVvFx2-HTYeh3LlEMESiRMfvfi2CAXGMwwLenQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323190/Reduced_Vessel_Elasticity_Alters_Cardiovascular_Structure_and_Function_in_Newborn_Mice"><img alt="Research paper thumbnail of Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522479/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323190/Reduced_Vessel_Elasticity_Alters_Cardiovascular_Structure_and_Function_in_Newborn_Mice">Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice</a></div><div class="wp-workCard_item"><span>Circulation Research</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically importan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically important in a pulsatile circulatory system. By studying newborn mice with reduced (Eln ϩ/Ϫ ) or no (Eln Ϫ/Ϫ ) elastin, we determined the effects of altered vessel elasticity on cardiovascular development and function. Eln Ϫ/Ϫ mice die within 72 hours of birth but are viable throughout fetal development when dramatic cardiovascular structural and hemodynamic changes occur. Thus, newborn Eln Ϫ/Ϫ mice provide unique insight into how a closed circulatory system develops when the arteries cannot provide the elastic recoil required for normal heart function. Compared with wild type, the Eln Ϫ/Ϫ aorta has a smaller unloaded diameter and thicker wall because of smooth muscle cell overproliferation and has greatly reduced compliance. Arteries in Eln Ϫ/Ϫ mice are also tortuous with stenoses and dilations. Left ventricular pressure is 2-fold higher than wild type, and heart function is impaired. Newborn Eln ϩ/Ϫ mice, in contrast, have normal heart function despite left ventricular pressures 25% higher than wild type. The major vessels have smaller unloaded diameters and longer lengths. The Eln ϩ/Ϫ aorta has additional smooth muscle cell layers that appear in the adventitia at or just before birth. These results show that the major adaptive changes in cardiovascular hemodynamics and in vessel wall structure seen in the adult Eln ϩ/Ϫ mouse are defined in late fetal development. Together, these results show that reduced elastin in mice leads to adaptive remodeling, whereas the complete lack of elastin leads to pathological remodeling and death. (Circ Res. 2009;104:1217-1224.) Key Words: blood pressure Ⅲ cardiovascular physiology Ⅲ development Ⅲ extracellular matrix Ⅲ large artery stiffness E lastin is a phylogenetically recent protein that imparts Original</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a14418ca2262e2bc60b4615fdcb1362" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522479,"asset_id":16323190,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522479/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323190]").text(description); $(".js-view-count[data-work-id=16323190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a14418ca2262e2bc60b4615fdcb1362" } } $('.js-work-strip[data-work-id=16323190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323190,"title":"Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice","internal_url":"https://www.academia.edu/16323190/Reduced_Vessel_Elasticity_Alters_Cardiovascular_Structure_and_Function_in_Newborn_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522479,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522479/thumbnails/1.jpg","file_name":"1217.pdf","download_url":"https://www.academia.edu/attachments/42522479/download_file","bulk_download_file_name":"Reduced_Vessel_Elasticity_Alters_Cardiov.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522479/1217-libre.pdf?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DReduced_Vessel_Elasticity_Alters_Cardiov.pdf\u0026Expires=1739773503\u0026Signature=PIOe~rG7WZiXWdKXdHhDgrj3MEvTs8Ap1kGOlPNUpd~hEAWh5sVjKGn5vfJLFLhm4Yz~9fSWiJZyzkPTLd0GlCVCmRwtre5YP2gCiEXDH~V61rK9L1qrBz4nrXkrPAxApA~CMii9tCGrF5kFTcjxssN8I0miRLR5LzuyC7XaqMETFQTu9qlJRurAoRCBYdaXo9Vi~L615LU1kt71zwcuiFZQYxxJMgVYplkyG7VOBz0jwrbtskL9BJ3kaEL9ySknIaOjFEWU124i8CwzWk0lD0HMdShfiycUME-0GAZqSkeXbOEC774R7dgmN220mchpILEpYddB1NC-oxZ5e0Wi8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3647685" id="papers"><div class="js-work-strip profile--work_container" data-work-id="106404884"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106404884/Measuring_left_ventricular_pressure_in_late_embryonic_and_neonatal_mice"><img alt="Research paper thumbnail of Measuring left ventricular pressure in late embryonic and neonatal mice" class="work-thumbnail" src="https://attachments.academia-assets.com/105611417/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106404884/Measuring_left_ventricular_pressure_in_late_embryonic_and_neonatal_mice">Measuring left ventricular pressure in late embryonic and neonatal mice</a></div><div class="wp-workCard_item"><span>Journal of visualized experiments : JoVE</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Blood pressure increases significantly during embryonic and postnatal development in vertebrate a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Blood pressure increases significantly during embryonic and postnatal development in vertebrate animals. In the mouse, blood flow is first detectable around embryonic day (E) 8.5 1. Systolic left ventricular (LV) pressure is 2 mmHg at E9.5 and 11 mmHg at E14.5 2. At these midembryonic stages, the LV is clearly visible through the chest wall for invasive pressure measurements because the ribs and skin are not fully developed. Between E14.5 and birth (approximately E21) imaging methods must be used to view the LV. After birth, mean arterial pressure increases from 30-70 mmHg from postnatal day (P) 2-35 3. Beyond P20, arterial pressure can be measured with solid-state catheters (i.e. Millar or Scisense). Before P20, these catheters are too big for developing mouse arteries and arterial pressure must be measured with custom pulled plastic catheters attached to fluid-filled pressure transducers 3 or glass micropipettes attached to servo null pressure transducers 4. Our recent work has shown that the greatest increase in blood pressure occurs during the late embryonic to early postnatal period in mice 5-7. This large increase in blood pressure may influence smooth muscle cell (SMC) phenotype in developing arteries and trigger important mechanotransduction events. In human disease, where the mechanical properties of developing arteries are compromised by defects in extracellular matrix proteins (i.e. Marfan's Syndrome 8 and Supravalvular Aortic Stenosis 9</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d94ecb5f1bcd895a34aaa272348acb39" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105611417,"asset_id":106404884,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105611417/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106404884"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106404884"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106404884; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106404884]").text(description); $(".js-view-count[data-work-id=106404884]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106404884; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106404884']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d94ecb5f1bcd895a34aaa272348acb39" } } $('.js-work-strip[data-work-id=106404884]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106404884,"title":"Measuring left ventricular pressure in late embryonic and neonatal mice","internal_url":"https://www.academia.edu/106404884/Measuring_left_ventricular_pressure_in_late_embryonic_and_neonatal_mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":105611417,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105611417/thumbnails/1.jpg","file_name":"pmc3376943.pdf","download_url":"https://www.academia.edu/attachments/105611417/download_file","bulk_download_file_name":"Measuring_left_ventricular_pressure_in_l.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105611417/pmc3376943-libre.pdf?1694224836=\u0026response-content-disposition=attachment%3B+filename%3DMeasuring_left_ventricular_pressure_in_l.pdf\u0026Expires=1739821487\u0026Signature=ZTct-GqrJtijpew4CPuh-nCvbG8C5qNjfG3reRO5vxBP~La7wTHQkEQumj76wJWTdr0HQCyL-XUSkSZ5DBthu19VbsPecZWmrMEgKsrXZR-Q3QKqeNfIn5io2Gvy1zCQpk3wLIp2-YzaMT~KXTN7UCAxt~prmhHpjt1FsLNIhkhjprnf5VjoXNK2QuaWjrnWn9HwZfoxFgXksy0r029PpIP3l9lWp-UgkKWdQISZfgrl2msi7EyyZscHNYpFVeMbrNY16~KEiz~y6Xr5aYxIf5V4T6YC7M3a8OmWFOKxbTGmnwUeTW6krvfplvWNNHohtMJR4zrU90-vQlUB9fLVpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="106404883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106404883/Elastin_arterial_mechanics_and_cardiovascular_disease"><img alt="Research paper thumbnail of Elastin, arterial mechanics, and cardiovascular disease" class="work-thumbnail" src="https://attachments.academia-assets.com/105611415/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106404883/Elastin_arterial_mechanics_and_cardiovascular_disease">Elastin, arterial mechanics, and cardiovascular disease</a></div><div class="wp-workCard_item"><span>American journal of physiology. Heart and circulatory physiology</span><span>, Jan 6, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Large, elastic arteries are composed of cells and a specialized extracellular matrix that provide...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on the heart and dampens pulsatile flow in distal arteries. We summarize elastin protein biochemistry, self-association behavior, crosslinking process, and multi-step elastic fiber assembly that provide large arteries with their unique mechanical properties. We present measures of passive arterial mechanics that depend on elastic fiber amounts and integrity such as the Windkessel effect, structural and material stiffness, and energy storage. We discuss supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa-1 (ADCL1), which are genetic disorders caused by mutations in the elastin gene. We present mouse models of SVAS, ADCL1, and graded elastin amounts that have been invaluable for understanding the role of elastin in arterial mechanics an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b481da691b79c919b72dd2088119d323" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105611415,"asset_id":106404883,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105611415/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106404883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106404883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106404883; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106404883]").text(description); $(".js-view-count[data-work-id=106404883]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106404883; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106404883']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b481da691b79c919b72dd2088119d323" } } $('.js-work-strip[data-work-id=106404883]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106404883,"title":"Elastin, arterial mechanics, and cardiovascular disease","internal_url":"https://www.academia.edu/106404883/Elastin_arterial_mechanics_and_cardiovascular_disease","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":105611415,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105611415/thumbnails/1.jpg","file_name":"Cocciolone_2018_AJP_Heart_Review-1xi2ctk.pdf","download_url":"https://www.academia.edu/attachments/105611415/download_file","bulk_download_file_name":"Elastin_arterial_mechanics_and_cardiovas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105611415/Cocciolone_2018_AJP_Heart_Review-1xi2ctk-libre.pdf?1694224843=\u0026response-content-disposition=attachment%3B+filename%3DElastin_arterial_mechanics_and_cardiovas.pdf\u0026Expires=1739821487\u0026Signature=gXICt9FuXEL~FkExnY46FH6SxgBZy03zG7HQfuWtP4xFd4wpdywZKCOJPwz-2NdUIgNIwXQtd8crJi78wXyd8y6ii9DwrNY7wJiUAz3-Ty7C4pVpFLPMYh13cWFrcEhcjzJDu16hkhtDYS~Jc1xf7L1BxI1w2as3CRXht-nPygWcIMV-tNujl4pI8FQQr6KegEXvesut3dsWMsw7-XjTzKhxEoz7chWASfa6LUT0VlXMFA2Hp-RbasMX6SCF1m4ig~WB2494ugkrLE~vyq0EuF8ykFKoTfmALP014NYrzh6RqSsmV6vyDMJIIYfoYLQcndRCul748KGzU3JWE92fRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404852"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87404852/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices"><img alt="Research paper thumbnail of One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87404852/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices">One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404852"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404852"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404852; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404852]").text(description); $(".js-view-count[data-work-id=87404852]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404852; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404852']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87404852]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404852,"title":"One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices","internal_url":"https://www.academia.edu/87404852/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404846"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87404846/A_Cell_Based_Constitutive_Relation_for_Bio_Artificial_Tissues"><img alt="Research paper thumbnail of A Cell-Based Constitutive Relation for Bio-Artificial Tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/91621722/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87404846/A_Cell_Based_Constitutive_Relation_for_Bio_Artificial_Tissues">A Cell-Based Constitutive Relation for Bio-Artificial Tissues</a></div><div class="wp-workCard_item"><span>Biophysical Journal</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d05c16e3439c3fd7c598254342e65530" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91621722,"asset_id":87404846,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91621722/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404846"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404846"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404846; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404846]").text(description); $(".js-view-count[data-work-id=87404846]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404846; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404846']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d05c16e3439c3fd7c598254342e65530" } } $('.js-work-strip[data-work-id=87404846]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404846,"title":"A Cell-Based Constitutive Relation for Bio-Artificial Tissues","internal_url":"https://www.academia.edu/87404846/A_Cell_Based_Constitutive_Relation_for_Bio_Artificial_Tissues","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":91621722,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91621722/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/91621722/download_file","bulk_download_file_name":"A_Cell_Based_Constitutive_Relation_for_B.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91621722/pdf-libre.pdf?1664277524=\u0026response-content-disposition=attachment%3B+filename%3DA_Cell_Based_Constitutive_Relation_for_B.pdf\u0026Expires=1739821487\u0026Signature=AfXzuJnsBaKkMCkfa421Cd1vU1G212Q3d6iybUcS03TvDTSVzTKv8aIaYlEEw~R65fEObqHvyMJCCJDxmSBYzbY4~giYJjRhqWzr2MgvZY3316Ne2Tk3kcHRjb65I6BhJx-XLNq-gAS6olZ6HBlyEAtAeTL1v5ywQtVPMxibIOpLoQPqijqt864biwQGNqpOjN2DqTIPia031Rm4iY0wnThQH6c0GmmL9oZlacCh2CBaUsQCXw-aIueY8RLuhtrOOcxflEtsQe0hXZoaXkHRF113MfRPgarC9a8q50jjyr9wuo-NSzH9CRMHqnqNJGQ0nnXeKX-iF2vrMH7i~naB-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404841"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87404841/Cell_Orientation_Influences_the_Biaxial_Mechanical_Properties_of_Fibroblast_Populated_Collagen_Vessels"><img alt="Research paper thumbnail of Cell Orientation Influences the Biaxial Mechanical Properties of Fibroblast Populated Collagen Vessels" class="work-thumbnail" src="https://attachments.academia-assets.com/91621716/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87404841/Cell_Orientation_Influences_the_Biaxial_Mechanical_Properties_of_Fibroblast_Populated_Collagen_Vessels">Cell Orientation Influences the Biaxial Mechanical Properties of Fibroblast Populated Collagen Vessels</a></div><div class="wp-workCard_item"><span>Annals of Biomedical Engineering</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="33140b193a1b2da66f14b4871c0e1fe4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91621716,"asset_id":87404841,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91621716/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404841"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404841"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404841; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404841]").text(description); $(".js-view-count[data-work-id=87404841]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404841; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404841']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "33140b193a1b2da66f14b4871c0e1fe4" } } $('.js-work-strip[data-work-id=87404841]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404841,"title":"Cell Orientation Influences the Biaxial Mechanical Properties of Fibroblast Populated Collagen Vessels","internal_url":"https://www.academia.edu/87404841/Cell_Orientation_Influences_the_Biaxial_Mechanical_Properties_of_Fibroblast_Populated_Collagen_Vessels","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":91621716,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91621716/thumbnails/1.jpg","file_name":"0203.pdf","download_url":"https://www.academia.edu/attachments/91621716/download_file","bulk_download_file_name":"Cell_Orientation_Influences_the_Biaxial.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91621716/0203-libre.pdf?1664277518=\u0026response-content-disposition=attachment%3B+filename%3DCell_Orientation_Influences_the_Biaxial.pdf\u0026Expires=1739821487\u0026Signature=YrOAfcUjDIjVA1Ny6TqqMItrv1SyTHcHt5cf2DftoPHqFAipfypOQR--0ws5IWGrNsdC1G~3D3aE6pZa~VNNMvyZmHuNMWzLVGwq4WBNMTsIHTc-WNuwXI2OLpQ-IHDxDsqTFWysFOVnY4Is-H3Cz4l0t26kYlVH68P6aOv-ZrJ3xIDw~GskGaBPQeT9vuQaTmPIpl09upgEzG7BGyJMJIl02OM1UboK-TphfpokYUuuWIKr7IiOi5s5RcFbBuTRBJgdVMk6jOnhdqs25r8IVgkaheshRkR-v1E8CjrhKGenDnhJCPGi3DH03IaajXxQYQNBCnSQ5-VMRvoqZZst-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87404753"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87404753/Mechanical_factors_direct_mouse_aortic_remodelling_during_early_maturation"><img alt="Research paper thumbnail of Mechanical factors direct mouse aortic remodelling during early maturation" class="work-thumbnail" src="https://attachments.academia-assets.com/91621596/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87404753/Mechanical_factors_direct_mouse_aortic_remodelling_during_early_maturation">Mechanical factors direct mouse aortic remodelling during early maturation</a></div><div class="wp-workCard_item"><span>Journal of The Royal Society Interface</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Numerous diseases have been linked to genetic mutations that lead to reduced amounts or disorgani...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Numerous diseases have been linked to genetic mutations that lead to reduced amounts or disorganization of arterial elastic fibres. Previous work has shown that mice with reduced amounts of elastin (Eln+/−) are able to live a normal lifespan through cardiovascular adaptations, including changes in haemodynamic stresses, arterial geometry and arterial wall mechanics. It is not known if the timeline and presence of these adaptations are consistent in other mouse models of elastic fibre disease, such as those caused by the absence of fibulin-5 expression (Fbln5−/−). AdultFbln5−/−mice have disorganized elastic fibres, decreased arterial compliance and high blood pressure. We examined mechanical behaviour of the aorta inFbln5−/−mice through early maturation when the elastic fibres are being assembled. We found that the physiologic circumferential stretch, stress and modulus ofFbln5−/−aorta are maintained near wild-type levels. Constitutive modelling suggests that elastin contributions to...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea87a86b9cec7af24e4eb86675918c76" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91621596,"asset_id":87404753,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91621596/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87404753"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87404753"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87404753; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87404753]").text(description); $(".js-view-count[data-work-id=87404753]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87404753; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87404753']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ea87a86b9cec7af24e4eb86675918c76" } } $('.js-work-strip[data-work-id=87404753]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87404753,"title":"Mechanical factors direct mouse aortic remodelling during early maturation","internal_url":"https://www.academia.edu/87404753/Mechanical_factors_direct_mouse_aortic_remodelling_during_early_maturation","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":91621596,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91621596/thumbnails/1.jpg","file_name":"rsif.2014.pdf","download_url":"https://www.academia.edu/attachments/91621596/download_file","bulk_download_file_name":"Mechanical_factors_direct_mouse_aortic_r.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91621596/rsif.2014-libre.pdf?1664278921=\u0026response-content-disposition=attachment%3B+filename%3DMechanical_factors_direct_mouse_aortic_r.pdf\u0026Expires=1739821487\u0026Signature=TV~D1~qNm9u~-yMeAjCIHdfyJboVnP2xDaFwZ6~atFzSYUh88StmJGa0Son8kb-ji0d07UVhmZ-qLGMXLX0DMBKXVXfnU2FEyC6rycZgkFirgoVcXS3qYJJer6ifBQkrmFKb3KBKXjYa5D33NB9XdoajjRiBs0DH0hUU8ChseVHIGB2FaD9ByuxHZsCLhOPjJS7r3UekqAf1Z3nZS8mhpF54H0-EVRDLMzhYnZnIIm9p9tOYVCdWfnzdVBtu~GQXAeh07qRqFkaD-sprH0UkzBdNE1a8-G2dQWI4EogimDXwoq3HivxoA86IfQcRAdiZQaCRq7hmI9Dhh2bE~dBPCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80475709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80475709/Crosslinked_elastic_fibers_are_necessary_for_low_energy_loss_in_the_ascending_aorta"><img alt="Research paper thumbnail of Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta" class="work-thumbnail" src="https://attachments.academia-assets.com/86844577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80475709/Crosslinked_elastic_fibers_are_necessary_for_low_energy_loss_in_the_ascending_aorta">Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta</a></div><div class="wp-workCard_item"><span>Journal of Biomechanics</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the large arteries, it is believed that elastin provides the resistance to stretch at low pres...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the large arteries, it is believed that elastin provides the resistance to stretch at low pressure, while collagen provides the resistance to stretch at high pressure. It is also thought that elastin is responsible for the low energy loss observed with cyclic loading. These tenets are supported through experiments that alter component amounts through protease digestion, vessel remodeling, normal growth, or in different artery types. Genetic engineering provides the opportunity to revisit these tenets through the loss of expression of specific wall components. We used newborn mice lacking elastin (Eln À/À) or two key proteins (lysyl oxidase, Lox À/À , or fibulin-4, Fbln4 À/À) that are necessary for the assembly of mechanicallyfunctional elastic fibers to investigate the contributions of elastic fibers to large artery mechanics. We determined component content and organization and quantified the nonlinear and viscoelastic mechanical behavior of Eln À/À , Lox À/À , and Fbln4 À/À ascending aorta and their respective controls. We confirmed that the lack of elastin, fibulin-4, or lysyl oxidase leads to absent or highly fragmented elastic fibers in the aortic wall and a 56-97% decrease in crosslinked elastin amounts. We found that the resistance to stretch at low pressure is decreased only in Eln À/À aorta, confirming the role of elastin in the nonlinear mechanical behavior of the aortic wall. Dissipated energy with cyclic loading and unloading is increased 53-387% in Eln À/À , Lox À/À , and Fbln4 À/À aorta, indicating that not only elastin, but properly assembled and crosslinked elastic fibers, are necessary for low energy loss in the aorta.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3d215bf70c3de0fb18c441395a571845" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86844577,"asset_id":80475709,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86844577/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80475709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80475709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80475709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80475709]").text(description); $(".js-view-count[data-work-id=80475709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80475709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80475709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3d215bf70c3de0fb18c441395a571845" } } $('.js-work-strip[data-work-id=80475709]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80475709,"title":"Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta","internal_url":"https://www.academia.edu/80475709/Crosslinked_elastic_fibers_are_necessary_for_low_energy_loss_in_the_ascending_aorta","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":86844577,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86844577/thumbnails/1.jpg","file_name":"kim_2017_eln_fbln4_lox_mechanics-1fbw7ob.pdf","download_url":"https://www.academia.edu/attachments/86844577/download_file","bulk_download_file_name":"Crosslinked_elastic_fibers_are_necessary.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86844577/kim_2017_eln_fbln4_lox_mechanics-1fbw7ob-libre.pdf?1654109616=\u0026response-content-disposition=attachment%3B+filename%3DCrosslinked_elastic_fibers_are_necessary.pdf\u0026Expires=1739821487\u0026Signature=NvICFUxogb19slsdJC2tKcNHJTCL57Xnx86UaK8ivtMIF1pOwWiOS3hgVAtMnFahJq5v8nuEjb-mMLxzgAzYysVMkrgCJl7klPa1v1t34JLS96SyJVzorDbknNoImxDCNbtOPZKBi0RskdBcGWVvuxyh0oXSUiFk2KgH46gDFeMPFUZI90Nf5BJ5MqSrr~ykVftcVGvD81QSJvI14ANFI9F4gg0FveAbG7aMH1XMdoe7nqMNKsC8UBj1YPDewVqlqRyMnj731TbAO04teWzNoOpPO~31ahOrdg~4BhYaLyURXORnrdRS3ZweEet~rUGcHFpzVzvFc-BS73IE-puyJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323216"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323216/Angiotensin_Converting_Enzyme_Induced_Activation_of_Local_Angiotensin_Signaling_Is_Required_for_Ascending_Aortic_Aneurysms_in_Fibulin_4_Deficient_Mice"><img alt="Research paper thumbnail of Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522485/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323216/Angiotensin_Converting_Enzyme_Induced_Activation_of_Local_Angiotensin_Signaling_Is_Required_for_Ascending_Aortic_Aneurysms_in_Fibulin_4_Deficient_Mice">Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice</a></div><div class="wp-workCard_item"><span>Science Translational Medicine</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fef4234805844bfb0b91ead35dc0a37b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522485,"asset_id":16323216,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522485/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323216"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323216"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323216; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323216]").text(description); $(".js-view-count[data-work-id=16323216]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323216; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323216']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fef4234805844bfb0b91ead35dc0a37b" } } $('.js-work-strip[data-work-id=16323216]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323216,"title":"Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice","internal_url":"https://www.academia.edu/16323216/Angiotensin_Converting_Enzyme_Induced_Activation_of_Local_Angiotensin_Signaling_Is_Required_for_Ascending_Aortic_Aneurysms_in_Fibulin_4_Deficient_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522485,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522485/thumbnails/1.jpg","file_name":"Angiotensin-Converting_Enzyme-Induced_Ac20160209-30589-1jriw7x.pdf","download_url":"https://www.academia.edu/attachments/42522485/download_file","bulk_download_file_name":"Angiotensin_Converting_Enzyme_Induced_Ac.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522485/Angiotensin-Converting_Enzyme-Induced_Ac20160209-30589-1jriw7x-libre.pdf?1455071579=\u0026response-content-disposition=attachment%3B+filename%3DAngiotensin_Converting_Enzyme_Induced_Ac.pdf\u0026Expires=1739821487\u0026Signature=CIMX1P5t3lVzjmLfXuUJGB~wzjuXfeWbaPyInAu1w63TwFDLU8IbKySCwegyvLr-k6ExN02uEVSp~EruzUR8HKGocV3wwqa2~o6lcg4Ouu31rRdcKYoV4b-a14iIiB97QrOlay6~hvwRuY7bqGz9ieh39m6lIb9vSBY3Z4tFxPQ5A7Rmc0XYxqUAkGEW7xD34TfgWikVvhrgkKc1BN2sG1gDQ41-SPLPYJ4OXwyAxYutz82rqgl8v~5C7nC3ByKwXfjes9K9DHOFo0UQH2OqZ7xFnmYY~lOmxktKY2H2JuehVBycP1Tcwy-kdbMqAs-Cv5jGQDUA5ykfugP8YpuAyw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323214"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323214/Vascular_Extracellular_Matrix_and_Arterial_Mechanics"><img alt="Research paper thumbnail of Vascular Extracellular Matrix and Arterial Mechanics" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323214/Vascular_Extracellular_Matrix_and_Arterial_Mechanics">Vascular Extracellular Matrix and Arterial Mechanics</a></div><div class="wp-workCard_item"><span>Physiological Reviews</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">An important factor in the transition from an open to a closed circulatory system was a change in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">An important factor in the transition from an open to a closed circulatory system was a change in vessel wall structure and composition that enabled the large arteries to store and release energy during the cardiac cycle. The component of the arterial wall in vertebrates that accounts for these properties is the elastic fiber network organized by medial smooth muscle. Beginning with the onset of pulsatile blood flow in the developing aorta, smooth muscle cells in the vessel wall produce a complex extracellular matrix (ECM) that will ultimately define the mechanical properties that are critical for proper function of the adult vascular system. This review discusses the structural ECM proteins in the vertebrate aortic wall and will explore how the choice of ECM components has changed through evolution as the cardiovascular system became more advanced and pulse pressure increased. By correlating vessel mechanics with physiological blood pressure across animal species and in mice with altered vessel compliance, we show that cardiac and vascular development are physiologically coupled, and we provide evidence for a universal elastic modulus that controls the parameters of ECM deposition in vessel wall development. We also discuss mechanical models that can be used to design better tissue-engineered vessels and to test the efficacy of clinical treatments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323214"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323214"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323214; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323214]").text(description); $(".js-view-count[data-work-id=16323214]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323214; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323214']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323214]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323214,"title":"Vascular Extracellular Matrix and Arterial Mechanics","internal_url":"https://www.academia.edu/16323214/Vascular_Extracellular_Matrix_and_Arterial_Mechanics","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323211"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323211/Cardiovascular_mechanics_in_newborn_ELN_and_mice"><img alt="Research paper thumbnail of Cardiovascular mechanics in newborn ELN+/+, +/− and−/− mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522465/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323211/Cardiovascular_mechanics_in_newborn_ELN_and_mice">Cardiovascular mechanics in newborn ELN+/+, +/− and−/− mice</a></div><div class="wp-workCard_item"><span>Matrix Biology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ELN+/− mice have increased blood pressure, smaller vessels and increased elastic lamellae. ELN−/−...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ELN+/− mice have increased blood pressure, smaller vessels and increased elastic lamellae. ELN−/− mice die soon after birth due to occlusive proliferation of smooth muscle cells (SMCs). In both cases, decreased elastin levels and altered mechanical signals may influence SMC phenotype. We have measured blood pressure, aortic wall structure and aortic mechanical properties of ELN+/+, +/− and−/− mice on postnatal day 0 (P0). Blood pressure in P0 ELN−/− mice is higher than ELN+/+ and +/−. Aortic inner diameter is significantly different between all genotypes, being smallest in ELN−/−, then ELN+/− and largest in ELN+/+. P0 ELN−/− aorta show disorganized, proliferating SMCs at the intimal surface, instead of the circumferentially organized layers seen in ELN+/+. ELN+/− aorta show elastin producing SMCs in the adventitia, instead of collagen producing fibroblasts as in ELN+/+. Adventitial progenitor cells can be stimulated to differentiate into elastin producing myofibroblasts after stretch induced injury. ELN−/− aorta have lower circumferential stresses at similar pressures compared to ELN+/+ and +/−, but almost identical stresses at physiologic pressure. ELN+/− aorta have increased circumferential stretch ratios at similar pressures compared to ELN+/+ and−/−. At P0, the characteristics of ELN−/− and +/− aorta suggest that circumferential stress induces SMCs to proliferate, while circumferential stretch induces progenitor cells to differentiate. This hypothesis will be investigated through similar studies at additional developmental time points.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9af21e7728e4c02c9c24efff1a0cf6b3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522465,"asset_id":16323211,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522465/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323211"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323211"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323211; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323211]").text(description); $(".js-view-count[data-work-id=16323211]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323211; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323211']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9af21e7728e4c02c9c24efff1a0cf6b3" } } $('.js-work-strip[data-work-id=16323211]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323211,"title":"Cardiovascular mechanics in newborn ELN+/+, +/− and−/− mice","internal_url":"https://www.academia.edu/16323211/Cardiovascular_mechanics_in_newborn_ELN_and_mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522465,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522465/thumbnails/1.jpg","file_name":"j.matbio.2008.09.311.pdf20160209-3321-canzo0","download_url":"https://www.academia.edu/attachments/42522465/download_file","bulk_download_file_name":"Cardiovascular_mechanics_in_newborn_ELN.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522465/j.matbio.2008.09.311-libre.pdf20160209-3321-canzo0?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DCardiovascular_mechanics_in_newborn_ELN.pdf\u0026Expires=1739821487\u0026Signature=V1X367Gc0c5TiqgUjllYp8VzNK9bllv~9QnNeVf4sMVp1OOYjY4gIHqqECyo9~detlv6PWUqgLncTBBG0p6YFnFfCmZvLzH76jn2G29kY7hYmZxb5V355ZWbZWdf6nwTw20NCH~yocTsx43WNJmvNcilMnLizZz87qRzfcjTX5IKFzJ-5UTeDNs8MHbidLkt-T9NW6h7F0fHTsWHbAZa43uE4uECkBxqi4dDLXr3TZ08UniqxQEqJTl5oiLYmy0L5GNjc~GaaVmPsijXLVY4th4p9Lcd0NTpZ9oodYQMRUlTQt5WYu4A3~Maa1X2e6B-oPnUU-MUjzrm4Fp3A~s8sQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323208"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323208/Characterization_of_the_C_terminus_of_mature_elastin"><img alt="Research paper thumbnail of Characterization of the C_terminus of mature elastin" class="work-thumbnail" src="https://attachments.academia-assets.com/42522473/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323208/Characterization_of_the_C_terminus_of_mature_elastin">Characterization of the C_terminus of mature elastin</a></div><div class="wp-workCard_item"><span>Matrix Biology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">strips was decreased when compared to WT controls. Although of lesser magnitude than the changes ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">strips was decreased when compared to WT controls. Although of lesser magnitude than the changes in ELN-deficient animals, the findings were none-the-less concordant. Thus, the data indicate that both quantitative and qualitative defects of ELN alter lung mechanical properties in a similar manner.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9d7bab5f4a234c419b5a8ff61d1f5b2e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522473,"asset_id":16323208,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522473/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323208"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323208"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323208; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323208]").text(description); $(".js-view-count[data-work-id=16323208]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323208; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323208']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9d7bab5f4a234c419b5a8ff61d1f5b2e" } } $('.js-work-strip[data-work-id=16323208]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323208,"title":"Characterization of the C_terminus of mature elastin","internal_url":"https://www.academia.edu/16323208/Characterization_of_the_C_terminus_of_mature_elastin","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522473,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522473/thumbnails/1.jpg","file_name":"j.matbio.2006.08.055.pdf20160209-30594-7aqpsr","download_url":"https://www.academia.edu/attachments/42522473/download_file","bulk_download_file_name":"Characterization_of_the_C_terminus_of_ma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522473/j.matbio.2006.08.055-libre.pdf20160209-30594-7aqpsr?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_the_C_terminus_of_ma.pdf\u0026Expires=1739821487\u0026Signature=VgrmvoMM1KDrdoIjr0dyDq~x0ESXOkxbi13rhjHUxRRHNsCrTttMk9xDVd-G6sechJnoNkO0NJxOPi5Sg6SxWvl5jnhh1ntbF5KPp9gqa6C-o05-EOY3ci1RStd1SUK3B5cbxBBOimFKPQoLIwZFp6~1TKIjOLC6wX9aHVTqBFw-CSB2nQRhD~w6nYyjmt0YPfy03gvjhUeEuf4WkDeHxjphWYVuVM~i86rchfMQ-B1nnqRRmr6Yx2bz~f~DEcoh3uVUEZ-vPcxXRVVh5A8Qvg6d6tZg3sjMGumjWfugaXk-~sE1Y-u8K5MzSG-~-hwcIZOMjJxeTxscDR5vNjpolg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323206"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323206/Hypertension_induced_cardiovascular_remodeling_in_ELN_Mice"><img alt="Research paper thumbnail of Hypertension induced cardiovascular remodeling in ELN+/_Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323206/Hypertension_induced_cardiovascular_remodeling_in_ELN_Mice">Hypertension induced cardiovascular remodeling in ELN+/_Mice</a></div><div class="wp-workCard_item"><span>Matrix Biology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">TB pathogenesis is characterized by the development of granulomas, organized aggregates of differ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">TB pathogenesis is characterized by the development of granulomas, organized aggregates of differentiated, infected macrophages. To identify relevant innate immune determinants of granuloma formation, we analyzed host gene expression in zebrafish embryos infected with Mycobacterium marinum (Mm). Mm is a close genetic relative of M. tb, the cause of human TB. Mm infection of zebrafish embryos recapitulates cardinal features of human TB including aggregation of infected macrophages into granulomas. Zebrafish embryos are optically transparent, allowing for in vivo monitoring of host-pathogen interactions. Since only innate immune cells are active during embryonic infection, innate immunity can be studied in isolation. As we have shown that early granuloma formation is enhanced by the mycobacterial virulence determinant RD1, we compared gene expression during infection with wild-type versus RD1 mutant Mm. MMP-9, MMP-13 and TIMP-2 as well as ECM genes were specifically upregulated. MMP-9 is upregulated in macrophages throughout the embryo whereas MMP-13 is upregulated only in epithelioid granuloma macrophages. Ongoing studies using gene-knock out technologies will determine the precise role of individual MMPs in tuberculous granuloma formation and infection outcome. Characterizing the roles of MMPs in early infection will lead to new insights into innate immune responses to mycobacteria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7070e3ebdefc83b754b0c73f42da4fd0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522467,"asset_id":16323206,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522467/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323206"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323206; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323206]").text(description); $(".js-view-count[data-work-id=16323206]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323206; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323206']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7070e3ebdefc83b754b0c73f42da4fd0" } } $('.js-work-strip[data-work-id=16323206]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323206,"title":"Hypertension induced cardiovascular remodeling in ELN+/_Mice","internal_url":"https://www.academia.edu/16323206/Hypertension_induced_cardiovascular_remodeling_in_ELN_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522467/thumbnails/1.jpg","file_name":"j.matbio.2006.08.038.pdf20160209-29783-1a9dhqo","download_url":"https://www.academia.edu/attachments/42522467/download_file","bulk_download_file_name":"Hypertension_induced_cardiovascular_remo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522467/j.matbio.2006.08.038-libre.pdf20160209-29783-1a9dhqo?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DHypertension_induced_cardiovascular_remo.pdf\u0026Expires=1739821487\u0026Signature=PhPSndYNDoCCLxsE6yjdrNa5th~twn5dGgWMM-cy07nmElrvb9Aky3ukx8wVzzNUHlafeC5PI0j8~kfBb-uPRbtRfGDN2L~VMG~1h3PiBeBuyAgKSAq46JVzXGHbM9-TZyeaI~nErsB03YxQygtDQbQvfat1jPkQY3oo89f~IcbnY8CjabNXrEnBNN-wrLpREUXS7~DktNtUS1~43SJHdbTECX~qFZhnFUkwjwuHQWz6RudRZtZWeTLiePvJUEDXMf5vISORWUaT1kv1ooraBaiadmlBtseLcfAXAuMCLAOd9Now0BjINQf20iFcArcy~AbeVNV26~kJFyTIh1g8UA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323204"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323204/Characterization_of_t1_relaxation_and_blood_myocardial_contrast_enhancement_of_NC100150_injection_in_cardiac_MRI"><img alt="Research paper thumbnail of Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323204/Characterization_of_t1_relaxation_and_blood_myocardial_contrast_enhancement_of_NC100150_injection_in_cardiac_MRI">Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI</a></div><div class="wp-workCard_item"><span>Journal of Magnetic Resonance Imaging</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A new ultrasmall superparamagnetic iron oxide (Clariscan; NC100150 Injection) was studied in dome...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A new ultrasmall superparamagnetic iron oxide (Clariscan; NC100150 Injection) was studied in domestic farm pigs. The T1 effects were characterized for blood and myocardium and the blood-myocardial contrast was measured in T1-weighted cine images. The contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) were measured at baseline and contrast doses of 1 and 5 mg Fe/kg body weight (bw) at end diastole and late systole. The T1 values for blood and myocardium were reduced by 97 and 43%, respectively, from baseline to 5 mg Fe/kg bw. The CNR was significantly improved with contrast at end diastole and late systole. The maximum improvement shown was 202% at 5 mg Fe/kg bw in late systole. The percent SNR enhancement was significantly higher in blood than myocardium at late systole. NC100150 Injection is an effective T1 shortening agent and can be used to improve blood-myocardial contrast in cine images of the heart. J. Magn. Reson. Imaging 1999;10:784-789.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323204"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323204"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323204; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323204]").text(description); $(".js-view-count[data-work-id=16323204]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323204; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323204']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323204]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323204,"title":"Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI","internal_url":"https://www.academia.edu/16323204/Characterization_of_t1_relaxation_and_blood_myocardial_contrast_enhancement_of_NC100150_injection_in_cardiac_MRI","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323202"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323202/Elastic_fiber_formation_A_dynamic_view_of_extracellular_matrix_assembly_using_timer_reporters"><img alt="Research paper thumbnail of Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters" class="work-thumbnail" src="https://attachments.academia-assets.com/42522471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323202/Elastic_fiber_formation_A_dynamic_view_of_extracellular_matrix_assembly_using_timer_reporters">Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters</a></div><div class="wp-workCard_item"><span>Journal of Cellular Physiology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To study the dynamics of elastic fiber assembly, mammalian cells were transfected with a cDNA con...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To study the dynamics of elastic fiber assembly, mammalian cells were transfected with a cDNA construct encoding bovine tropoelastin in frame with the Timer reporter. Timer is a derivative of the DsRed fluorescent protein that changes from green to red over time and, hence, can be used to distinguish new from old elastin. Using dynamic imaging microscopy, we found that the first step in elastic fiber formation is the appearance of small cell surface-associated elastin globules that increased in size with time (microassembly). The elastin globules are eventually transferred to pre-existing elastic fibers in the extracellular matrix where they coalesce into larger structures (macroassembly). Mechanical forces associated with cell movement help shape the forming, extracellular elastic fiber network. Time-lapse imaging combined with the use of Timer constructs provides unique tools for studying the temporal and spatial aspects of extracellular matrix formation by live cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="46fe903b9de9dcc379d1967299195c2e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522471,"asset_id":16323202,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323202"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323202"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323202; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323202]").text(description); $(".js-view-count[data-work-id=16323202]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323202; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323202']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "46fe903b9de9dcc379d1967299195c2e" } } $('.js-work-strip[data-work-id=16323202]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323202,"title":"Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters","internal_url":"https://www.academia.edu/16323202/Elastic_fiber_formation_A_dynamic_view_of_extracellular_matrix_assembly_using_timer_reporters","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522471/thumbnails/1.jpg","file_name":"Elastic_fiber_formation_A_dynamic_view_o20160209-27371-1to67g5.pdf","download_url":"https://www.academia.edu/attachments/42522471/download_file","bulk_download_file_name":"Elastic_fiber_formation_A_dynamic_view_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522471/Elastic_fiber_formation_A_dynamic_view_o20160209-27371-1to67g5-libre.pdf?1455071577=\u0026response-content-disposition=attachment%3B+filename%3DElastic_fiber_formation_A_dynamic_view_o.pdf\u0026Expires=1739821487\u0026Signature=BktYy~9ieMmsCmxlqnR7zJDIZW8zqTVL4AtWkALr7yu74JDiOUJbaTLwKy6-OzBeEHXBDD9nzWferdWAwi0mKzZgx4qRre~03E-UI3gU5emU~1GtMj2x184jqNv6E7hxt7EmuMWpZlHsr~wcw4Kdj54iM72vf2arzfxa2DLgC174UOmpL~Ernd9nKRLXHffXEtMZLSjtR1m3SjxbPCXyBqYQ0paeEBikvJ6GEp6fDdUFMITYPOK~cKB0elYF-~08Alin9YSoEHeEiGU5TP27uOOPh8XeZR2LBJUtDcDpkEa8eFJX0qwKXvvB415~RFCJdLJ-zAxYtmP4NwRyN3t9Aw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323200"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323200/The_Effects_of_Elastic_Fiber_Protein_Insufficiency_and_Treatment_on_the_Modulus_of_Arterial_Smooth_Muscle_Cells"><img alt="Research paper thumbnail of The Effects of Elastic Fiber Protein Insufficiency and Treatment on the Modulus of Arterial Smooth Muscle Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323200/The_Effects_of_Elastic_Fiber_Protein_Insufficiency_and_Treatment_on_the_Modulus_of_Arterial_Smooth_Muscle_Cells">The Effects of Elastic Fiber Protein Insufficiency and Treatment on the Modulus of Arterial Smooth Muscle Cells</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elastic fibers are critical for the mechanical function of the large arteries. Mechanical effects...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elastic fibers are critical for the mechanical function of the large arteries. Mechanical effects of elastic fiber protein deficiency have been investigated in whole arteries, but not in isolated smooth muscle cells (SMCs). The elastic moduli of SMCs from elastin (Eln-/-) and fibulin-4 (Fbln4-/-) knockout mice were measured using atomic force microscopy. Compared to control SMCs, the modulus of Eln-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln-/- SMC modulus is rescued by soluble or α elastin treatment. Altered gene expression, specifically of calponin, suggests that SMC phenotypic modulation may be responsible for the modulus changes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323200"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323200"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323200; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323200]").text(description); $(".js-view-count[data-work-id=16323200]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323200; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323200']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323200]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323200,"title":"The Effects of Elastic Fiber Protein Insufficiency and Treatment on the Modulus of Arterial Smooth Muscle Cells","internal_url":"https://www.academia.edu/16323200/The_Effects_of_Elastic_Fiber_Protein_Insufficiency_and_Treatment_on_the_Modulus_of_Arterial_Smooth_Muscle_Cells","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16268475"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16268475/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices"><img alt="Research paper thumbnail of One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices" class="work-thumbnail" src="https://attachments.academia-assets.com/42594447/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16268475/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices">One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://wustl.academia.edu/ElliotElson">Elliot Elson</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RuthOkamoto">Ruth Okamoto</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://wustl.academia.edu/JessicaWagenseil">Jessica Wagenseil</a></span></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d209400ab572244d47e18fa8c6ce998d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42594447,"asset_id":16268475,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42594447/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16268475"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16268475"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16268475; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16268475]").text(description); $(".js-view-count[data-work-id=16268475]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16268475; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16268475']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d209400ab572244d47e18fa8c6ce998d" } } $('.js-work-strip[data-work-id=16268475]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16268475,"title":"One-Dimensional Viscoelastic Behavior of Fibroblast Populated Collagen Matrices","internal_url":"https://www.academia.edu/16268475/One_Dimensional_Viscoelastic_Behavior_of_Fibroblast_Populated_Collagen_Matrices","owner_id":35360383,"coauthors_can_edit":true,"owner":{"id":35360383,"first_name":"Elliot","middle_initials":null,"last_name":"Elson","page_name":"ElliotElson","domain_name":"wustl","created_at":"2015-09-28T08:18:54.588-07:00","display_name":"Elliot Elson","url":"https://wustl.academia.edu/ElliotElson"},"attachments":[{"id":42594447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42594447/thumbnails/1.jpg","file_name":"One-dimensional_viscoelastic_behavior_of20160211-14533-18unrrm.pdf","download_url":"https://www.academia.edu/attachments/42594447/download_file","bulk_download_file_name":"One_Dimensional_Viscoelastic_Behavior_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42594447/One-dimensional_viscoelastic_behavior_of20160211-14533-18unrrm-libre.pdf?1455237962=\u0026response-content-disposition=attachment%3B+filename%3DOne_Dimensional_Viscoelastic_Behavior_of.pdf\u0026Expires=1739821487\u0026Signature=KuMoG30ERxh9tiKBte9CBTLXzz3QO2xMkHpyod81Q3MaPHa00h5WhNgPL0qSkC3gzo7BCAcZzIY0FSD~yLwPY~diZtmsx-~MwoVWkj1ay5nBwN46g5UH9xtuW6BRMRmXWPw3tuh~c0h5hziv2ivvKOe2IZWe8vCCDIIzl0Ytei4rqlGawnJI9~Otds2OKUXUfZuFKjN5iVjPMJ2veRS-elxXk3vV1Kl5GfHwzhlw0dKhFasC77NucwEbU~4093MkzU9bf6RItLQIF75I9cRLnkpHelFxbhsruGeJw7gLTbot~Fk4J-wR9HixgWbdJ94nK92jev6LTAKG0DcT4DqlMA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323196/Effect_of_Storage_Duration_on_the_Mechanical_Behavior_of_Mouse_Carotid_Artery"><img alt="Research paper thumbnail of Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery" class="work-thumbnail" src="https://attachments.academia-assets.com/42522474/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323196/Effect_of_Storage_Duration_on_the_Mechanical_Behavior_of_Mouse_Carotid_Artery">Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Determining arterial mechanical properties is important for understanding the work done by the he...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Determining arterial mechanical properties is important for understanding the work done by the heart and how it changes with cardiovascular disease. Ex vivo tests are necessary to apply various loads to the artery and obtain data to model and predict the behavior under any load. Most ex vivo tests are performed within 24 hours of dissection, so the tissue is still "alive". For large elastic arteries, however, the passive mechanical behavior is attributed mostly to the very stable proteins, elastin and collagen. If the testing equipment fails, is in use, or is located at another facility, it would be useful to store the vessels and postpone the tests until the equipment is available. The goal of this study is to determine the effects of storage time on the mechanical behavior of the common carotid artery from adult mice. Each artery was tested after storage for 1-28 days in physiologic saline at 4°C. There were no significant effects of storage time on the arterial diameter or force at each pressure, but there were significant effects on the stretch ratio and stress at each pressure. The significant effects on the stretch ratio and stress were due to decreases in the unloaded dimensions with storage time, when measured from cut arterial rings. When the unloaded dimensions were measured instead from histology sections, there were no significant changes with storage time. We conclude that histology sections yield a more consistent measurement of the unloaded dimensions and that there are no significant changes in the mechanical behavior of mouse carotid artery with storage up to 28 days.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f9895c3f09e22aae435629e4ce68f980" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522474,"asset_id":16323196,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522474/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323196"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323196"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323196; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323196]").text(description); $(".js-view-count[data-work-id=16323196]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323196; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323196']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f9895c3f09e22aae435629e4ce68f980" } } $('.js-work-strip[data-work-id=16323196]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323196,"title":"Effect of Storage Duration on the Mechanical Behavior of Mouse Carotid Artery","internal_url":"https://www.academia.edu/16323196/Effect_of_Storage_Duration_on_the_Mechanical_Behavior_of_Mouse_Carotid_Artery","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522474,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522474/thumbnails/1.jpg","file_name":"Effect_of_storage_duration_on_the_mechan20160209-27376-j51q79.pdf","download_url":"https://www.academia.edu/attachments/42522474/download_file","bulk_download_file_name":"Effect_of_Storage_Duration_on_the_Mechan.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522474/Effect_of_storage_duration_on_the_mechan20160209-27376-j51q79-libre.pdf?1455071578=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Storage_Duration_on_the_Mechan.pdf\u0026Expires=1739821487\u0026Signature=HfNrRVJakoh9iZR~2PMGpU-kA4sleyXBI60dMMcujRXZn1I2YIMr8-MDFysj7xTHila~zDWOaWMNauWiWr7qRZ6lQU9KkXgBvMeqPaCzZ4IteAlclwNFjkbSH-iFCrTuu91wdjXfUIh5PmJ7cOHajbxVu0hiOUvNbmTOQgMvRdqQJxPwVjMyEux2YwmmAp7YkqCKHDldh62fLfSVe9PzRS23QVOeTaHVTcWlPZSHMb47r8KG3BZMsoOPmcQv3Gu6eTuWsVaQ1U5SRixh14AdokyeRPbDHfmTd2t8dtQ80epXTzO0918Qm4~jTlFxxWEivN8Jrj1lg0KQaaJJ~IvUsA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/16323194/Murrays_Law_in_Elastin_Haploinsufficient_Eln_and_Wild_Type_WT_Mice"><img alt="Research paper thumbnail of Murray's Law in Elastin Haploinsufficient ( Eln+/− ) and Wild-Type (WT) Mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/16323194/Murrays_Law_in_Elastin_Haploinsufficient_Eln_and_Wild_Type_WT_Mice">Murray's Law in Elastin Haploinsufficient ( Eln+/− ) and Wild-Type (WT) Mice</a></div><div class="wp-workCard_item"><span>Journal of Biomechanical Engineering</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Using either the principle of minimum energy or constant shear stress, a relation can be derived ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Using either the principle of minimum energy or constant shear stress, a relation can be derived that predicts the diameters of branching vessels at a bifurcation. This relation, known as Murray&amp;amp;amp;#39;s Law, has been shown to predict vessel diameters in a variety of cardiovascular systems from adult humans to developing chicks. The goal of this study is to investigate Murray&amp;amp;amp;#39;s Law in vessels from mice that are haploinsufficient for the elastin protein (Eln+/-). Elastin is one of the major proteins in the blood vessel wall and is organized in concentric rings, known as lamellae, with smooth muscle cells (SMCs) around the vessel lumen. Eln+/- mice have an increased number of lamellae, as well as smaller, thinner vessels. It is possible that due to decreased amounts of elastin available for vessel wall remodeling during development and in adulthood, Eln+/- vessels would not follow Murray&amp;amp;amp;#39;s Law. We examined vessel bifurcations in six different physiologic regions, including the brain, heart, epidermis, ceocum (or cecum), testes, and intestines, in Eln+/- mice and wild-type (WT) littermates. All vessels were between 40 and 300 μm in diameter. We found that the diameters of both Eln+/- and WT vessels have an average of 13% error from the diameters predicted by Murray&amp;amp;amp;#39;s Law, with no significant differences between genotypes or physiologic regions. The data suggest that vessels are optimized to follow Murray&amp;amp;amp;#39;s Law, despite limitations on the proteins available for growth and remodeling of the vessel wall.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323194]").text(description); $(".js-view-count[data-work-id=16323194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16323194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323194,"title":"Murray's Law in Elastin Haploinsufficient ( Eln+/− ) and Wild-Type (WT) Mice","internal_url":"https://www.academia.edu/16323194/Murrays_Law_in_Elastin_Haploinsufficient_Eln_and_Wild_Type_WT_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323192/Alternative_Splicing_and_Tissue_specific_Elastin_Misassembly_Act_as_Biological_Modifiers_of_Human_Elastin_Gene_Frameshift_Mutations_Associated_with_Dominant_Cutis_Laxa"><img alt="Research paper thumbnail of Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa" class="work-thumbnail" src="https://attachments.academia-assets.com/42522518/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323192/Alternative_Splicing_and_Tissue_specific_Elastin_Misassembly_Act_as_Biological_Modifiers_of_Human_Elastin_Gene_Frameshift_Mutations_Associated_with_Dominant_Cutis_Laxa">Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa</a></div><div class="wp-workCard_item"><span>Journal of Biological Chemistry</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: A humanized mouse was developed to study elastin assembly and the pathogenesis of cut...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: A humanized mouse was developed to study elastin assembly and the pathogenesis of cutis laxa. Results: Mutant transcripts incorporate into elastic fibers of skin and lung with adverse effects but not aorta. Conclusion: Elastin frameshift mutations alter elastin assembly domains. Significance: The mechanism of elastic fiber assembly may not be the same in all tissues.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d4851798b739bdc447387a7ad677b4f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522518,"asset_id":16323192,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522518/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323192]").text(description); $(".js-view-count[data-work-id=16323192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d4851798b739bdc447387a7ad677b4f3" } } $('.js-work-strip[data-work-id=16323192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323192,"title":"Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa","internal_url":"https://www.academia.edu/16323192/Alternative_Splicing_and_Tissue_specific_Elastin_Misassembly_Act_as_Biological_Modifiers_of_Human_Elastin_Gene_Frameshift_Mutations_Associated_with_Dominant_Cutis_Laxa","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522518,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522518/thumbnails/1.jpg","file_name":"Alternative_splicing_and_tissue-specific20160209-20574-1425yex.pdf","download_url":"https://www.academia.edu/attachments/42522518/download_file","bulk_download_file_name":"Alternative_Splicing_and_Tissue_specific.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522518/Alternative_splicing_and_tissue-specific20160209-20574-1425yex-libre.pdf?1455071575=\u0026response-content-disposition=attachment%3B+filename%3DAlternative_Splicing_and_Tissue_specific.pdf\u0026Expires=1739821488\u0026Signature=Y2fOV4BCKjn6RKwrZix-ykiwrsPzDv~wkc5VYcm3zZUYbGt97qX4eO1r-dOTpN9t9vGLXYFSYMLfbLN4t2JRyTXl5cL2FOC-oPjdkJXQql0Km~sk~ANHzdp6pp~s~JHAc4wtVcsWAdetuJbGCJTvYoAliDpF-d6GuUH7tAaBH65MN70upCburJqI1QQViNuKpv4TV4~wghwkYWeTPe4DUcW3oVVZ~fbC2Hvgudjr0hLcYITvpVteFvxVbLx3ZqcFZm5N3DI0tSfIv8arU5pZ2tAD32ZxKdNTUObYGzie8lOu0h0NqVvFx2-HTYeh3LlEMESiRMfvfi2CAXGMwwLenQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16323190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16323190/Reduced_Vessel_Elasticity_Alters_Cardiovascular_Structure_and_Function_in_Newborn_Mice"><img alt="Research paper thumbnail of Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/42522479/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16323190/Reduced_Vessel_Elasticity_Alters_Cardiovascular_Structure_and_Function_in_Newborn_Mice">Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice</a></div><div class="wp-workCard_item"><span>Circulation Research</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically importan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically important in a pulsatile circulatory system. By studying newborn mice with reduced (Eln ϩ/Ϫ ) or no (Eln Ϫ/Ϫ ) elastin, we determined the effects of altered vessel elasticity on cardiovascular development and function. Eln Ϫ/Ϫ mice die within 72 hours of birth but are viable throughout fetal development when dramatic cardiovascular structural and hemodynamic changes occur. Thus, newborn Eln Ϫ/Ϫ mice provide unique insight into how a closed circulatory system develops when the arteries cannot provide the elastic recoil required for normal heart function. Compared with wild type, the Eln Ϫ/Ϫ aorta has a smaller unloaded diameter and thicker wall because of smooth muscle cell overproliferation and has greatly reduced compliance. Arteries in Eln Ϫ/Ϫ mice are also tortuous with stenoses and dilations. Left ventricular pressure is 2-fold higher than wild type, and heart function is impaired. Newborn Eln ϩ/Ϫ mice, in contrast, have normal heart function despite left ventricular pressures 25% higher than wild type. The major vessels have smaller unloaded diameters and longer lengths. The Eln ϩ/Ϫ aorta has additional smooth muscle cell layers that appear in the adventitia at or just before birth. These results show that the major adaptive changes in cardiovascular hemodynamics and in vessel wall structure seen in the adult Eln ϩ/Ϫ mouse are defined in late fetal development. Together, these results show that reduced elastin in mice leads to adaptive remodeling, whereas the complete lack of elastin leads to pathological remodeling and death. (Circ Res. 2009;104:1217-1224.) Key Words: blood pressure Ⅲ cardiovascular physiology Ⅲ development Ⅲ extracellular matrix Ⅲ large artery stiffness E lastin is a phylogenetically recent protein that imparts Original</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a14418ca2262e2bc60b4615fdcb1362" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42522479,"asset_id":16323190,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42522479/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16323190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16323190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16323190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16323190]").text(description); $(".js-view-count[data-work-id=16323190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16323190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16323190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a14418ca2262e2bc60b4615fdcb1362" } } $('.js-work-strip[data-work-id=16323190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16323190,"title":"Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice","internal_url":"https://www.academia.edu/16323190/Reduced_Vessel_Elasticity_Alters_Cardiovascular_Structure_and_Function_in_Newborn_Mice","owner_id":35431762,"coauthors_can_edit":true,"owner":{"id":35431762,"first_name":"Jessica","middle_initials":null,"last_name":"Wagenseil","page_name":"JessicaWagenseil","domain_name":"wustl","created_at":"2015-09-30T06:55:52.521-07:00","display_name":"Jessica Wagenseil","url":"https://wustl.academia.edu/JessicaWagenseil"},"attachments":[{"id":42522479,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42522479/thumbnails/1.jpg","file_name":"1217.pdf","download_url":"https://www.academia.edu/attachments/42522479/download_file","bulk_download_file_name":"Reduced_Vessel_Elasticity_Alters_Cardiov.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42522479/1217-libre.pdf?1455071576=\u0026response-content-disposition=attachment%3B+filename%3DReduced_Vessel_Elasticity_Alters_Cardiov.pdf\u0026Expires=1739773503\u0026Signature=PIOe~rG7WZiXWdKXdHhDgrj3MEvTs8Ap1kGOlPNUpd~hEAWh5sVjKGn5vfJLFLhm4Yz~9fSWiJZyzkPTLd0GlCVCmRwtre5YP2gCiEXDH~V61rK9L1qrBz4nrXkrPAxApA~CMii9tCGrF5kFTcjxssN8I0miRLR5LzuyC7XaqMETFQTu9qlJRurAoRCBYdaXo9Vi~L615LU1kt71zwcuiFZQYxxJMgVYplkyG7VOBz0jwrbtskL9BJ3kaEL9ySknIaOjFEWU124i8CwzWk0lD0HMdShfiycUME-0GAZqSkeXbOEC774R7dgmN220mchpILEpYddB1NC-oxZ5e0Wi8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "867e31ec53b3bd9519e972773d2d92a2947c771b990065b8427c4e394a0d36ff", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="UL6qjRi8x6ua72SQyOkcDcEAkbYd2cCvTA084l66FEq5YyP9ggGRaUJ_aRnmvZXaVEZTcuE2l2JzyaatWTvGMA" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://wustl.academia.edu/JessicaWagenseil" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="hLjxUuDbbkoHYaK8Dk5LcZgTkaoVAZjsgsJSiOkRqVhtZXgiemY4iN_xrzUgGsKmDVVTbunuzyG9BsjH7pB7Ig" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>