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class="masthead__media"> <picture> <img src='https://www.ppd.com/wp-content/uploads/2023/06/hepatology-liver-disease_2110531817-1600x600.jpg' width='1600' height='600' srcset='' alt='hepatology-liver-disease' class='object-pos-center' /> </picture> </div> <div class="masthead__overlay"> </div>  <div class="masthead__content-wrapper alignwide"> <div class="masthead__content"> <h1 class="masthead__title">Hepatology: Unrivaled Liver Disease Expertise</h1> </div> </div> </section> <div class="breadcrumbs alignfull"><div class="breadcrumbs__inner"><div class="breadcrumbs__wrapper"><div class="breadcrumbs"><span><span><a href="https://www.ppd.com/therapeutic-expertise/">Therapeutic Expertise</a></span> <span class="breadcrumb-separator"></span> <span class="breadcrumb_last" aria-current="page">Hepatology</span></span></div></div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_d6996e-ed" class="em-row-layout-inner em-margin-top--default em-margin-bottom--default em-tablet-margin-top--default em-tablet-margin-bottom--default em-mobile-margin-top--default em-mobile-margin-bottom--default em-layout-id_d6996e-ed"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-left-golden em-tab-layout-left-golden em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--default em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column5772 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--medium em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--medium em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--medium em-mobile-padding-left--none"> <p>The therapeutic area of liver diseases has significant unmet medical need with ailments such as non-alcoholic steatohepatitis (NASH), alpha 1-antitrypsin deficiency (A1ATD), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).</p> <p>In NASH, despite a large patient population, there is not an approved disease-specific drug therapy. Prevalence of NASH alone is expected to increase 63% by 2030 and is projected to become the leading indication for liver transplants.</p> <p>Liver disease clinical studies face considerable challenges, including: </p> <ul class="mt-0 wp-block-list"> <li>High screen-fail rates</li> <li>Lack of investigator familiarity with the disease</li> <li>Patient safety</li> <li>Training for new sites</li> <li>Patient recruitment</li> <li>Patient diversity, in particular for NASH studies</li> <li>Vendor selection and management</li> </ul> <p>Drug developers tackling complex liver diseases need an experienced contract research organization as their hepatology CRO. We apply the expansive global footprint, development capabilities and expertise we’ve built in clinical drug studies to accelerate your liver drug development program.</p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-emagine-button"><a class="wp-block-emagine-button__more has-purple-background-color block-btn block-btn--sm block-btn--primary" style="background-color:#633a97" href="#connectwithus" rel=""><span class="block-btn__hover" style="color:#fff;background-color:#4f2683;border-color:transparent">Accelerate your hepatology clinical trial</span></a></div> </div></div> <div class="wp-block-emagine-column emagine-column1897 inner-column-2 intro-sidebar"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><section id="anchor-link-menu-block_f8f4e2ab246423407741bc7e7e82751d" class="anchor-link-menu alignfull"> <div class="anchor-link-menu__title"> On this page </div> <div class="anchor-link-menu__links"> <ul> <li><a href="#hepatology-experience">Hepatology Experience</a></li> <li><a href="#primary-biliary-cholangitis">Primary Biliary Cholangitis Case Study</a></li> <li><a href="#nash-case-study">NASH Case Study</a></li> <li><a href="#patient-centricity">Patient Centricity in Hepatology Clinical Trials</a></li> <li><a href="#liver-disease-services">End-to-end Liver Disease Services</a></li> </ul> </div> </section> <div style="height:25px" aria-hidden="true" class="wp-block-spacer"></div> <section id="cta-block-block_36b5dab2c75b8f85861dcaa0a505d5b6" class="cta-block aligndefault has-blue-background-color" > <div class="inner aligndefault"> <div class="cta-block__body"> <div class="cta-block__content"><p style="font-size: 1.26em"><strong>Incorporating the patient’s voice in NASH clinical trials</strong></p> </div> </div> <div class="cta-block__button"> <a class="cta__button " href="/therapeutic-expertise/hepatology-cro/nash-clinical-trial-patients-webinar/" target="">Watch the webinar on demand</a> </div> </div> </section> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_1d0710-33" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-row-has-bg em-layout-id_1d0710-33"><div class="em-row-layout-overlay em-row-overlay-gradient"></div><div class="em-row-column-wrap em-has-1-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-inherit em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--default em-mobile-padding-bottom--default alignfull"> <div class="wp-block-emagine-column emagine-column955 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><section id="media-content-block_53ed35d65ffc2597b9624f54a12f42db" class="media-content alignfull has-bg-image dark-text thirds-layout align-content-center " style=""> <div class="alignwide align-bg"> <div class="media-content__image bg-image" style="background-image: url(https://www.ppd.com/wp-content/uploads/2022/02/shutterstock_1924512605.jpg);"></div> <div class="media-content__content has-container right-content"> <div class="content-container"> <h2 class="media-content__title2">Why choose our hepatology CRO solutions</h2> <div class="media-content__desc"><p>Chronic liver disease is growing in prevalence and contributes to rising rates of cirrhosis, liver failure and liver cancer. Meanwhile, mortality rates for alcoholic-associated liver disease and non-alcoholic fatty liver disease (NAFLD) <a href="https://pubmed.ncbi.nlm.nih.gov/35988691/#:~:text=As%20shown%20in%20this%20study,non%2DHispanic%20White%2C%20and%20Alaska">substantially increased</a> during the COVID-19 pandemic.</p> <p>The imperative to rapidly deliver a treatment for liver diseases calls for a clinical research strategy built around experience, speed and global reach.</p> </div> </div> </div> </div> </section> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="hepatology-experience"><div id="em-layout-id_4a25b3-c8" class="em-row-layout-inner em-margin-top--default em-margin-bottom--none em-tablet-margin-top--default em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_4a25b3-c8"><div class="em-row-column-wrap em-has-3-columns em-gutter-default em-row-valign-top em-row-layout-center-exwide em-tab-layout-center-exwide em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--none em-tablet-padding-top--default em-tablet-padding-bottom--none em-mobile-padding-top--none em-mobile-padding-bottom--none alignwide"> <div class="wp-block-emagine-column emagine-column6614 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"></div></div> <div class="wp-block-emagine-column emagine-column1054 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading has-text-align-center">A wealth of experience and expertise in liver disease research</h3> <p class="has-text-align-center">As a complement to our broad experience in <a href="https://www.ppd.com/therapeutic-expertise/gastroenterology/">gastroenterology</a>, we have demonstrated expertise in the evolving hepatology clinical trials landscape.</p> <h4 class="wp-block-heading has-text-align-center">Our wide-ranging, global experience with liver studies spans</h4> </div></div> <div class="wp-block-emagine-column emagine-column2800 inner-column-3"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"></div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_d6d82f-d7" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_d6d82f-d7"><div class="em-row-column-wrap em-has-4-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-two-grid em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--none em-mobile-padding-top--default em-mobile-padding-bottom--none alignwide"> <div class="wp-block-emagine-column emagine-column9102 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><div id="countup-block-block_4535645c081ea4ebd75135edad94b35d" class="countup-block alignfull"> <div class="countup-block__wrapper purple"> <div class="countup-block__hexagon"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2020/03/icon-microscope.svg" alt=""> </div> <div class="countup-block__content"> <span class="countup-block__number" data-number="68">0</span> <div class="countup-block__label"><p>liver disease studies</p> </div> </div> </div> </div> </div></div> <div class="wp-block-emagine-column emagine-column8684 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><div id="countup-block-block_3f9f0851de8d268fceed6bff35c3738e" class="countup-block alignfull"> <div class="countup-block__wrapper purple"> <div class="countup-block__hexagon"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2021/10/icon-patient-populations.svg" alt=""> </div> <div class="countup-block__content"> <span class="countup-block__number" data-number="5800">0</span> <span class="countup-block__before">+</span> <div class="countup-block__label"><p>patients</p> </div> </div> </div> </div> </div></div> <div class="wp-block-emagine-column emagine-column4350 inner-column-3"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><div id="countup-block-block_fa6de53158cd8ccce2fd00f8bc762f64" class="countup-block alignfull"> <div class="countup-block__wrapper purple"> <div class="countup-block__hexagon"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2021/08/icon-gmp-building.svg" alt=""> </div> <div class="countup-block__content"> <span class="countup-block__number" data-number="1600">0</span> <span class="countup-block__before">+</span> <div class="countup-block__label"><p>active sites</p> </div> </div> </div> </div> </div></div> <div class="wp-block-emagine-column emagine-column1643 inner-column-4"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><div id="countup-block-block_ef9f57c4bcce8478b12f6f10ee76bef9" class="countup-block alignfull"> <div class="countup-block__wrapper purple"> <div class="countup-block__hexagon"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2021/01/icon-north-America-60074e8e337f9.svg" alt=""> </div> <div class="countup-block__content"> <span class="countup-block__number" data-number="40">0</span> <span class="countup-block__before">+</span> <div class="countup-block__label"><p>countries</p> </div> </div> </div> </div> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_1aa06c-e4" class="em-row-layout-inner em-margin-top--none em-margin-bottom--default em-tablet-margin-top--default em-tablet-margin-bottom--default em-mobile-margin-top--none em-mobile-margin-bottom--default em-layout-id_1aa06c-e4"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--default em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column3859 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--medium em-mobile-padding-left--none"> <figure class="wp-block-image size-full"><img fetchpriority="high" decoding="async" width="800" height="533" src="https://www.ppd.com/wp-content/uploads/2022/10/future-of-paperless-laboratories-article.jpg" alt="" class="wp-image-24069" srcset="https://www.ppd.com/wp-content/uploads/2022/10/future-of-paperless-laboratories-article.jpg 800w, https://www.ppd.com/wp-content/uploads/2022/10/future-of-paperless-laboratories-article-300x200.jpg 300w, https://www.ppd.com/wp-content/uploads/2022/10/future-of-paperless-laboratories-article-768x512.jpg 768w, https://www.ppd.com/wp-content/uploads/2022/10/future-of-paperless-laboratories-article-60x40.jpg 60w" sizes="(max-width: 800px) 100vw, 800px" /></figure> </div></div> <div class="wp-block-emagine-column emagine-column6367 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading has-text-align-left">Our experts have led clinical research across a range of liver indications, including:</h3> <ul class="wp-block-list"> <li>Alpha 1-antitrypsin deficiency</li> <li> Non-alcoholic fatty liver disease (NAFLD)</li> <li> Non-alcoholic steatohepatitis (NASH)</li> <li> Primary biliary cholangitis (PBC)</li> <li> Primary sclerosing cholangitis (PSC)</li> </ul> </div></div> </div></div></div> <section id="cta-block-block_929eb56a8e1ea19e4195a2fa6b95467f" class="cta-block alignfull has-blue-background-color" > <div class="inner aligndefault"> <div class="cta-block__body"> <div class="cta-block__content"><h3 style="color: #fff">Build your clinical research strategy with an experienced partner.</h3> </div> </div> <div class="cta-block__button"> <a class="cta__button " href="#connectwithus" target="">Connect with us</a> </div> </div> </section> <div class="wp-block-emagine-columns alignfull" id="case-studies"><div id="em-layout-id_1fdf1a-13" class="em-row-layout-inner em-margin-top--default em-margin-bottom--none em-tablet-margin-top--default em-tablet-margin-bottom--none em-mobile-margin-top--default em-mobile-margin-bottom--none em-layout-id_1fdf1a-13"><div class="em-row-column-wrap em-has-1-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-inherit em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--none em-tablet-padding-top--default em-tablet-padding-bottom--none em-mobile-padding-top--default em-mobile-padding-bottom--none aligndefault"> <div class="wp-block-emagine-column emagine-column7719 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--small em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none" style="background:rgba(255, 255, 255, 0.9)"> <h2 class="wp-block-heading has-text-align-center">Case studies</h2> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_7e7ebf-9e" class="em-row-layout-inner em-margin-top--none em-margin-bottom--default em-tablet-margin-top--none em-tablet-margin-bottom--default em-mobile-margin-top--none em-mobile-margin-bottom--default em-layout-id_7e7ebf-9e"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--default em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column8096 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none" style="background:rgba(255, 255, 255, 0.9)"> <div style="height:1px" aria-hidden="true" id="primary-biliary-cholangitis" class="wp-block-spacer"></div> <div id="em-accordions-95d746b5-205c-4c7c-8fb2-feb9b2156891" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions alignfull"><div class="em-panel__container"><div id="controls-accordions-95d746b5-205c-4c7c-8fb2-feb9b2156891-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-95d746b5-205c-4c7c-8fb2-feb9b2156891-panel-tab-title" class="em-panel__control"><h2>Successful enrollment in primary biliary cholangitis clinical trial</h2></div><div id="accordions-95d746b5-205c-4c7c-8fb2-feb9b2156891-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-95d746b5-205c-4c7c-8fb2-feb9b2156891-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <p><strong>Background</strong>: A client faced enrollment challenges when conducting a Phase III primary biliary cholangitis study that required optional liver biopsy, FibroScan, and eDiary for Pruritus and QoL scales.</p> <p><strong>Challenges</strong>: With a rare disease like PBC, the sponsor faced a number of challenges, including:</p> <ul class="wp-block-list"> <li>50% Screen-fail rate</li> <li>Difficulty identifying the right patients</li> <li>Slow start up</li> </ul> <p><strong>Outcomes</strong>: By partnering with us, the client met the deadline for last patient in by:</p> <ul class="wp-block-list"> <li>Engaging with the sites with face-to-face meetings</li> <li>Implementing slot management via ePIP</li> <li>Creating a knowledge sharing community</li> </ul> </div></div></div></div> </div></div> <div class="wp-block-emagine-column emagine-column6632 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <div style="height:1px" aria-hidden="true" id="nash-case-study" class="wp-block-spacer"></div> <div id="em-accordions-44d3e050-3921-44c4-b662-65189b357291" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions alignfull"><div class="em-panel__container"><div id="controls-accordions-44d3e050-3921-44c4-b662-65189b357291-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-44d3e050-3921-44c4-b662-65189b357291-panel-tab-title" class="em-panel__control"><h2>Overcoming enrollment challenges in a NASH clinical trial</h2></div><div id="accordions-44d3e050-3921-44c4-b662-65189b357291-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-44d3e050-3921-44c4-b662-65189b357291-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <p><strong>Background</strong>: A client pursuing a Phase IIa NASH study experienced enrollment difficulties. Key study procedures included FibroScan and noninvasive biomarkers for primary endpoint assessment.</p> <p><strong>Challenges</strong>:</p> <ul class="wp-block-list"> <li>Significant delays in site activations in two EU countries. </li> <li>10% increase in enrolled patients was implemented at the trial’s midpoint</li> <li>Higher than planned screen-fail rate</li> <li>Loss of Ukraine’s participation</li> </ul> <p><strong>Outcomes</strong>: By partnering with us, the client engaged with sites and developed a strategic enrollment plan, which achieved:</p> <ul class="wp-block-list"> <li>Last patient in within 10 months of first site activation, keeping enrollment on time with a 10% increase in patients </li> <li>Dropout rate 5% (nine patients discontinued)</li> <li>Non-enrolling sites 4.3%</li> </ul> </div></div></div></div> </div></div> </div></div></div> <section id="media-content-block_77add13647c6fd0ef3b28f2e9bd9962a" class="media-content alignfull has-blue-l-background-color bg-color has-bg-image dark-text thirds-layout align-content-center " style=""> <div class="alignwide align-bg"> <div class="media-content__image bg-image" style="background-image: url(https://www.ppd.com/wp-content/uploads/2021/12/customer-iStock-1068721890.jpg);"></div> <div class="media-content__content has-container right-content"> <div class="content-container"> <h2 class="media-content__title2">Faster study startup than industry benchmarks</h2> <div class="media-content__desc"><p>Over the past five years, we have consistently exceeded study startup industry benchmarks in liver diseases.</p> <p>Our median cycle times for liver studies are up to:</p> <ul> <li>30% faster than benchmark for final protocol received to 50% of sites activated</li> <li>10% faster than benchmark for final protocol received to first subject screened</li> <li>20% faster than benchmark for final protocol received to 50% of subjects enrolled</li> </ul> <p>Our customers benefit from our investments in people, process improvement and technology implementation to drive quicker startup for their clinical trials.</p> </div> </div> </div> </div> </section> <div class="wp-block-emagine-columns alignfull" id="patient-centricity"><div id="em-layout-id_033232-75" class="em-row-layout-inner em-margin-top--default em-margin-bottom--none em-tablet-margin-top--default em-tablet-margin-bottom--default em-mobile-margin-top--default em-mobile-margin-bottom--none em-layout-id_033232-75"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-left-golden em-tab-layout-inherit em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--default em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column2961 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading">Patient centricity that accelerates your clinical hepatology trials</h2> <p>Your needs and goals become ours, and nowhere is that more apparent than in our investment in the patient. Our expertise enables sponsors to develop a study-specific patient engagement strategy and integrate patient insights into key study decisions.</p> <h3 class="wp-block-heading">Our patient-first approach enables our customers to</h3> </div></div> <div class="wp-block-emagine-column emagine-column554 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"></div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull alignundefined"><div id="em-layout-id_ee051d-f7" class="em-row-layout-inner em-margin-top--none em-margin-bottom--default em-tablet-margin-top--none em-tablet-margin-bottom--default em-mobile-margin-top--none em-mobile-margin-bottom--default em-layout-id_ee051d-f7"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--none em-padding-bottom--default em-tablet-padding-top--none em-tablet-padding-bottom--default em-mobile-padding-top--none em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column1618 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <div id="em-accordions-5fc5a05e-8606-4647-a981-b17722b584f1" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions aligndefault"><div class="em-panel__container"><div id="controls-accordions-5fc5a05e-8606-4647-a981-b17722b584f1-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-5fc5a05e-8606-4647-a981-b17722b584f1-panel-tab-title" class="em-panel__control"><h4>Engage better with diverse communities</h4></div><div id="accordions-5fc5a05e-8606-4647-a981-b17722b584f1-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-5fc5a05e-8606-4647-a981-b17722b584f1-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <p>A diversity plan for NASH trials begins with understanding the impacted patient population and driving inclusive clinical development, particularly within Hispanic communities. Each of our studies includes a Patient Diversity Team that provides strategic counsel and materials for study teams to optimize trial design/start-up, enrollment, and retention of diverse populations.</p> </div></div></div></div> <div id="em-accordions-25d6891c-b559-458e-a74c-554c087dd9d3" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions aligndefault"><div class="em-panel__container"><div id="controls-accordions-25d6891c-b559-458e-a74c-554c087dd9d3-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-25d6891c-b559-458e-a74c-554c087dd9d3-panel-tab-title" class="em-panel__control"><h4>Elevate patient outreach and education with patient advocacy groups (PAGs)</h4></div><div id="accordions-25d6891c-b559-458e-a74c-554c087dd9d3-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-25d6891c-b559-458e-a74c-554c087dd9d3-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <p>PAGs, when coordinated and approved by the sponsor, play an important role in patient outreach, starting with advertising and sharing knowledge about studies on the PAG’s website. Dedicated discussions with a PAG inform and entice the target patients, enabling sponsors to accelerate recruitment.</p> </div></div></div></div> <div id="em-accordions-c3f35e88-3fe3-414c-a82e-cfdb0dd6c800" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions aligndefault"><div class="em-panel__container"><div id="controls-accordions-c3f35e88-3fe3-414c-a82e-cfdb0dd6c800-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-c3f35e88-3fe3-414c-a82e-cfdb0dd6c800-panel-tab-title" class="em-panel__control"><h4>Improve patient engagement, recruitment and retention</h4></div><div id="accordions-c3f35e88-3fe3-414c-a82e-cfdb0dd6c800-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-c3f35e88-3fe3-414c-a82e-cfdb0dd6c800-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <p>Retention success begins with site investment, including investing in coordinator knowledge, which increases the participant’s confidence in their health care team. By building patient confidence in the trial coordinator, we strengthen patient trust and better the likelihood of retention.</p> </div></div></div></div> </div></div> <div class="wp-block-emagine-column emagine-column1448 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <div id="em-accordions-f9b52760-b7fd-418d-9d03-e4f90b46e720" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions aligndefault"><div class="em-panel__container"><div id="controls-accordions-f9b52760-b7fd-418d-9d03-e4f90b46e720-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-f9b52760-b7fd-418d-9d03-e4f90b46e720-panel-tab-title" class="em-panel__control"><h4>Optimize all stages of study delivery based on the patient perspective</h4></div><div id="accordions-f9b52760-b7fd-418d-9d03-e4f90b46e720-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-f9b52760-b7fd-418d-9d03-e4f90b46e720-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <ul class="wp-block-list"> <li>We work with patient partners throughout the design, operationalization, implementation and dissemination of our studies. We also leverage StudyGage, our proprietary preference-data-based tool, which simulates participation rates in clinical studies. This enables our customers to elevate their studies by: <ul class="wp-block-list"> <li>Aligning your recruitment and diversity strategies around a clear understanding of the patient pathway</li> <li>Testing and optimizing your operational strategies</li> <li>Ensuring your patient-facing materials are accessible and impactful</li> </ul> </li> </ul> </div></div></div></div> <div id="em-accordions-6c869f9c-7aea-4a12-a66c-a87ccd723faf" class="wp-block-emagine-blocks-accordion em-block-accordion em-panels em-panels--accordions aligndefault"><div class="em-panel__container"><div id="controls-accordions-6c869f9c-7aea-4a12-a66c-a87ccd723faf-panel-tab-title" role="tab" aria-selected="false" aria-expanded="false" aria-controls="accordions-6c869f9c-7aea-4a12-a66c-a87ccd723faf-panel-tab-title" class="em-panel__control"><h4>Make trials more accessible</h4></div><div id="accordions-6c869f9c-7aea-4a12-a66c-a87ccd723faf-panel-tab-title" role="tabpanel" class="em-panel" aria-labelledby="controls-accordions-6c869f9c-7aea-4a12-a66c-a87ccd723faf-panel-tab-title" aria-hidden="false"><div class="em-panel__content"> <p>By implementing <a href="https://www.ppd.com/how-we-help/decentralized-clinical-trials/">digital and decentralized trial solutions</a>, we enable our customers to accelerate recruitment, cut trial timelines and remove barriers to reach diverse patient populations.</p> </div></div></div></div> </div></div> </div></div></div> <section id="media-content-block_19f17205baa32f80ef774c84ff16a8ea" class="media-content alignfull has-bg-image dark-text thirds-layout align-content-center " style=""> <div class="alignwide align-bg"> <div class="media-content__image bg-image" style="background-image: url(https://www.ppd.com/wp-content/uploads/2022/10/DCT.jpg.jpg);"></div> <div class="media-content__content has-container right-content"> <div class="content-container"> <h3 class="media-content__title2">Comprehensive, global site recruitment plan</h3> <div class="media-content__desc"><p>Our integrated approach to site planning and collaboration enhances enrollment and retention in highly competitive areas. Our customers benefit from our:</p> <ul> <li><strong>Expansive network of sites around the globe. </strong>Sponsors gain access to sites and patients in new regions, including in Hispanic communities where NASH is prevalent, thanks to our reliable and expanding network of sites.</li> <li><strong>Strong relationships with key sites and investigators.</strong> Our customers meet or surpass their study milestones when we build a site plan that levies our years of experience managing clinical trials around the world.</li> <li><strong>Collaborative study planning</strong>. From site initiation through the final visit, we work closely with the site to create a customized recruitment plan, identifying the necessary patient recruitment materials, reviewing the pre-screening and screening processes, and formalizing the site’s approach and goals.</li> </ul> </div> </div> </div> </div> </section> <section id="liver-disease-services" class="media-content alignfull has-bg-image dark-text thirds-layout invert-mobile align-content-center " style=""> <div class="alignwide align-bg"> <div class="media-content__content has-container left-content"> <div class="content-container"> <h3 class="media-content__title2">End-to-end liver disease CRO services</h3> <div class="media-content__desc"><p>With access to the full range of expertise across Thermo Fisher Scientific, our customers are better able to navigate risk across:</p> <ul> <li><strong>Research and discovery:</strong> Scientific technologies to enable a faster start and a deep understanding of the medical requirements</li> <li><strong>Process development and optimization:</strong> Solutions and technologies to fine-tune the science, advance the strongest candidates and design clinical trials</li> <li><strong>Pre-clinical:</strong> Laboratory support and other analytical analyses models to determine if a drug candidate is safe to test in humans</li> <li><strong>Clinical trials:</strong> Full-service clinical research capabilities coupled with asset, logistics, and regulatory management to navigate drug development and prove efficacy</li> <li><strong>Commercialization and production:</strong> <a href="https://www.evidera.com/what-we-do/value-market-access-consulting/">Market access</a>, regulatory expertise, supply chain management, manufacturing solutions, and distribution to get to market faster and drive more value</li> <li><strong>Rare and pediatric expertise: </strong>Shape trial design, strategy, and delivery for adult and pediatric rare indications with the <a href="https://www.ppd.com/therapeutic-expertise/rare-disease/#rare-disease-and-pediatrics-center-of-excellence">PPD™ Rare Disease and Pediatrics Center of Excellence</a></li> <li><strong>Routine and specialty testing</strong>: Central Lab services offer a full complement of solutions including routine testing, biopsy sample management and logistics, and pathology</li> <li><strong>Automated data flow for patient and biopsy tracking</strong>: A clear pathway that leverages internal resources, mitigates tracking challenges and increases efficiency</li> </ul> </div> </div> </div> <div class="media-content__image bg-image" style="background-image: url(https://www.ppd.com/wp-content/uploads/2022/12/AthloneGMPLab.jpg);"></div> </div> </section> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_b76b34-5f" class="em-row-layout-inner em-margin-top--default em-margin-bottom--none em-tablet-margin-top--default em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_b76b34-5f"><div class="em-row-column-wrap em-has-1-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-inherit em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--none em-mobile-padding-bottom--default aligndefault"> <div class="wp-block-emagine-column emagine-column7359 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading has-text-align-center">Additional hepatology resources</h3> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_56236a-e1" class="em-row-layout-inner em-margin-top--none em-margin-bottom--default em-tablet-margin-top--none em-tablet-margin-bottom--default em-mobile-margin-top--none em-mobile-margin-bottom--default em-layout-id_56236a-e1"><div class="em-row-column-wrap em-has-3-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--none em-padding-bottom--default em-tablet-padding-top--none em-tablet-padding-bottom--default em-mobile-padding-top--none em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column1860 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><a href="https://www.ppd.com/blog/prioritize-pediatric-populations-nash-clinical-trials/" target="" id="ppd-card-block_1731231483d10300b893f8d2e0d6ac12" class="ppd-card alignfull "> <div class="ppd-card__image"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2023/06/nash-blog-shutterstock_1984226180-760x440.jpg" alt=""> </div> <div class="ppd-card__inner"> <div class="ppd-card__top"> <div class="ppd-card__title">How to prioritize pediatric populations in NASH trials</div> </div> <div class="ppd-card__bottom"> <span class="ppd-card__link" >Discover tips for advancing pediatric NASH clinical trials</span> </div> </div> </a> </div></div> <div class="wp-block-emagine-column emagine-column3811 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><a href="https://www.ppd.com/wp-content/uploads/2022/12/PPD-Biotech-NASH-experience.pdf" target="_blank" id="ppd-card-block_a5362cc4381014a1d6c53ca46f71fd64" class="ppd-card alignfull "> <div class="ppd-card__image"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2022/11/PPD242_DCT-site-challenges-card.jpg" alt="DCT-site-challenges-card"> </div> <div class="ppd-card__inner"> <div class="ppd-card__top"> <div class="ppd-card__title">Biotech NASH experience overview</div> </div> <div class="ppd-card__bottom"> <span class="ppd-card__link" >Learn more about the biotech NASH experience</span> </div> </div> </a> </div></div> <div class="wp-block-emagine-column emagine-column3602 inner-column-3"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><a href="https://www.ppd.com/wp-content/uploads/2022/12/NASH-experience-for-competitive-environment.pdf" target="_blank" id="ppd-card-block_9eac42b9126ec33d9b9a132da979ab8d" class="ppd-card alignfull "> <div class="ppd-card__image"> <img decoding="async" src="https://www.ppd.com/wp-content/uploads/2024/08/NASH-overview-thumb.jpg" alt="NASH overview thumbnail"> </div> <div class="ppd-card__inner"> <div class="ppd-card__top"> <div class="ppd-card__title">NASH experience overview</div> </div> <div class="ppd-card__bottom"> <span class="ppd-card__link" >Learn more about the NASH experience</span> </div> </div> </a> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="connectwithus"><div id="em-layout-id_924125-c9" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-row-has-bg em-layout-id_924125-c9"><div class="em-row-column-wrap em-has-1-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-inherit em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge aligndefault"> <div class="wp-block-emagine-column emagine-column5729 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading has-text-align-left">Connect with us to accelerate your hepatology clinical trial</h3> <p class="has-text-align-left">Our hepatology experts stand ready to partner with you on breakthrough medicine. <br>Let’s connect.</p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <script> window.hsFormsOnReady = window.hsFormsOnReady || []; window.hsFormsOnReady.push(()=>{ hbspt.forms.create({ portalId: 9454064, formId: "0239cf34-bfb8-4541-92cc-029b9171a2a7", target: "#hbspt-form-1732671523000-1924300446", region: "na1", })}); </script> <div class="hbspt-form" id="hbspt-form-1732671523000-1924300446"></div> </div></div> </div></div></div> </article> </main> <footer class="site-footer" role="contentinfo"> <div class="alignwide"> <div class="site-footer__inner"> <div class="site-footer__menu-wrap"> <div class="site-footer__menu"> <ul class="menu 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