CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '92c848859e26ce63',cH: 'wy4th8JlWDcTfTZ9corApLCC0nZOb63Fwd9oAC1jPj4-1744015888-1.2.1.1-Nc5qXb.RQvrYpbc1QkNME_8cwd.vwHyU2yl4U2YQvSzFpFdnuZIHB4QXBzMQenxj',cUPMDTk: "\/doi\/10.1021\/bm1006773?__cf_chl_tk=yx3FMkw9LjJHyPormFQhRgv1uSoZvGop9r_eVL.oYBg-1744015888-1.0.1.1-GYsJME9.SwM5r3MtOBy3qI_sKAy3DdLm411P09QYzUw",cFPWv: 'g',cITimeS: '1744015888',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/bm1006773?__cf_chl_f_tk=yx3FMkw9LjJHyPormFQhRgv1uSoZvGop9r_eVL.oYBg-1744015888-1.0.1.1-GYsJME9.SwM5r3MtOBy3qI_sKAy3DdLm411P09QYzUw",md: "4_yY9kHoM5xNFw9yAJkjSLv7PgdgpqY.AUS4OE1RxWI-1744015888-1.2.1.1-XwyRyqgdbNBxeFlsr9tVzzVl7Hn4DGqe3NR4LUHZ.3a5r.4Kkk0xmKzEf4ah_7LMbVwv7X9aqcNpNTwA.zWKjsOGu7nks7jIRqvhMrUm0Z.7GTiXMu8LMYGAVbU7GdIpXYkMhd5_ozcxuOsfhwHCiiOce7QZMGHDx_hjFE1N.Vk3Hu5oGexnu.Rn6EIWY1BorWfSNuBhh25ziDgzpZdaIIoeEeMLy9Z1g3yg.nTCv9StKbYubh8Bp33Fm93Uz2V..fcRGbFveqbL_WVda_OQURbhGgpzI9wr4vFNVYhepcptFTeJMux_Rd2CLbpaZzKcHaVsXb_XMkQ1bnTvvJO3YlxoailabTr7pQWz.ldhaNBnsq1MWY7EYQXaEdcoq1tPnj4Ktxi4wzE2TnaUKcMAVdxSvAQy8WmNMbeBcwcGPyCcnNInrcCMeqaejFu.WZ2g9pKX1emMszp7ux8WJAQWAIz4jTqypfyMZSGUd7J4UgtSpTe0VCZrzdqTaQ8g5BlawKo.IoKv30QpjpFlZRCDV.OJyxUgo7jYvYEBM0ofaL5VDG_bsCYeUNbSB0ESw1HkcgZqRyQ3PNACAH47q.zrKc7xW6zePujskluKdYL0rfxX7pVZOOfSD_Bpc2AcZCbxaHVhFQWSu2.LRnEcwhPR6lXRQqvXF0fGDrs.LokrZq5w2n9claTESI.YC05mhYIURIEnIpb5GZFWjP048zoHYNin_T7tEGJbCLMoYqKcKflwRM81VCBOz4hkrX417j9SbEjdgkV5Ldjms5KxonNONtwvO9C3SIC80wW04sIciVML7poQ_w7n0_d0MjnZnJWCcqyqXV.JAuENtsQY7CH4lNIdJ43fV6uPpURhXPcnMeH5SetrcA0_Iu4Xx4QtPu1DEukHhCTR29eOq9TgvCa1FxOr85qgp2MWe80EcZtulp5upoQBg_Gg38RsIAUSaIdeiQHRDHrcULD7REhCm8jD7YI0aWkeMaU_Wc79edHefQH._LZwR4giEiHuEP3cQwYwmG0ix1RVFHwsHTbX4JinEqGADC70Mm8VXnfpMLR2h0zOvLKS73DxKVX.UD_L3x4BkVLDjHoEetjlbLzpUne3iDyonx5UqhbOfExJiZGSgiz5MKRUynvTuYqyxbzRymLL7J2V8jgeJojtn5uikMSrPsWuNk6RDo7ZfMIXUY1bFxuWoCP8XxNZmETVQcxnugx.nVIu22WSmsQm8cidEw1QJB.mI.89bL878TB3VKnaIwB4dFnhoUMq_VEWvt8uq.Ot",mdrd: "gshyQMGN1FWCZUE1nUEUEtBgPkfnnh9qIm0_7OOGOGU-1744015888-1.2.1.1-RtZB8OnIeahKsuhjZihXSyLIMEofHX5j.WbI6hftGDTgokgCr9dnWzFtN74_xtbQBN7fgJaw518puNXZzCvh9Q3bZK_8v_quZlN2Bu0mNUYAnykESMCKPgSVQU.GjIneav9oTlWidrk6a5qra.eYQwQeIv3.DkCVIAFUqhOAy_pGlLIUvWiN0NNfiH8hOJ7z_3idkuouin8oqkK0TODlHwS7p821Edh8J6vsIkKGXURi1_nbgqiuHKTlzPCnHWedpKMnP3lO8L6EWKsfv87hHZ0lFGc17_3VXMQvT3MovZh6We4JB0ZWWD9e1_dp9ByyGex1Tc0YxcouAMZF6Aw5L6vZEy7wMAM9vqWZy_0qKd4p_T.EKkZfQbPEmINqGgzR7YXaTL6gggEW9mRiQuJaFMbM7Ozrxelwo53b1C4QX4uGpN5.Yap8psrsG2Bgok_ehOCMxduEaRn67ve8Hxsd0JypR040s.gP2CFL5cFe5koWe9SArj9sW_4RUHQKWuMxm3wE1oDVbuctrk9vRqcG31UtnBt4pAIYX2vw43tf1ewlfzHhvnXjiY.FD.nzJhj52X6Nx5Zm9KKbN_W.OPD_BccEX6UthRyUqoqJzU8Wkz2sCLYEOPgeoqinKwaSA1P5K6Og2ixpTbhdC0irSnW0Rf.Voxuu5ItxUGPw6ltI53ppJKIjwUInvO4XlVDiYHTXB8tX2P9j4a0Vyv7tgyZEFbDuevFrp0feAVsEBR1rX8CZwQ94yAFkKkNQvtgyP6K8vY8UxUx1_NoAsMP_j.TdF63IINoAWyR6H1thvJeyyCKXzKlhXWEMuYWSxr0BRObbA3DEQ5At9dq_Ez_fGHE0tyxusfbONsiGDo._KzUfm8RrsAqyIWe484rgIvskO_9YUZhFEvLxHkwIBgNrxygKpT8owevorQCHsGFK5CyZ0GtiEy5qJALSREkUBiZQx2EbxkGNbFoFDJLY03D3ZcrLo.7fMruLx1v.tBzNWjto6trcpu4Pq5fyLFMoCuJfkm1LhxWYi01yKLSavPXe22ACQaDKoo6JrQMpfdgFg1V78UESbmmDsD8BzEn5d65YJ26gXrHukvB0WVSkqn2V3x.OzhNgLoxxj1VNCN89cUZBJ1GpHvwtSU.KU7Nf02gc5C_9YIQpbRmaVZtKpnlZaV6p9iIcVk_gDxIhureLyfshVbVbfsJpWeHLtGMBEqbij9ZHkRCrFzwqnerRJYctjHTo60FzykzvNT.Ll.fOpPclOZOczY61ch.vOxL0q04SvX9c45eGd7uDia4rFlXMJU09QBvswF9rwnR2XtF_bMYwp.mlEXqZY4SkzG3SpnAYExF65opLKKISfjVVlFqnV934zzWOgcVBX7e.BGvot3sf8sFb7Iv.j1lk5S0eItHNqQzcpI_39aati1zFWfNa51zqFqWvhUdwoH_o894oF03fQr3dAzqvpSs8uz90d8Rw0pLKMY58tegfx879lwFP1Ydt6CJ7HsApzLfTqqSoSHd570c5p_E084dEKacQinfP4_BeACeZgrNIVMJTsnhNJU.zxmVkH_v6bPe2AGHbUAo8LoLgSdUOM3jEjZQ5C3nwHyyrUVZONYH7Sga9W9j35QPjDwP7G8Yyk78M_DvYEycu5mZcdOQrwe0YLy72JmjRY.eRFcPf8435LiFKeeYQMddJIzK9wN703rkM1qkFkFGXDljWwqeah5a3Q6Ehhi.Bb_AhfmUob0Ao5N4h1oDGSCpRrP0l1qW7YQXC_ogWrnQIN1UhpJLgQczlPq3v9AMdN.o1ZMZwf9I1JaQPLvDvftljFZzikau1pt3l1Z.zOArVNlrE5zo.fXZOSEsxgssUIrmVn5p8pGipWlaYMBAPfFo8DdbJiBciMhe25jQVCFmdiHDUfVq6Y3wB5kE5i83zWs7Nimjo_8XygyGwx.d9yg_Cmv1n6221M2F07WvuaoYoB7RnuhNRKmTpo0ZnSDNay6_kr2bJWZ1Hn_Mznwh2OIzCAqILz3judtujPY1tAP_0Hu5NWCtn18QgI_nOSbdFmu5twfQl1W4x1.37A7ObUEunOQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=92c848859e26ce63';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/bm1006773?__cf_chl_rt_tk=yx3FMkw9LjJHyPormFQhRgv1uSoZvGop9r_eVL.oYBg-1744015888-1.0.1.1-GYsJME9.SwM5r3MtOBy3qI_sKAy3DdLm411P09QYzUw" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>