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data-dom-id="Pill-react-component-a701c34e-d438-4dee-a953-85b77b3e0ec9"></div> <div id="Pill-react-component-a701c34e-d438-4dee-a953-85b77b3e0ec9"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="31767894" href="https://www.academia.edu/Documents/in/Inorganic_Chemistry"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Inorganic Chemistry"]}" data-trace="false" data-dom-id="Pill-react-component-0f516561-83a7-4c12-a9d5-265b6822a15e"></div> <div id="Pill-react-component-0f516561-83a7-4c12-a9d5-265b6822a15e"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Pietro Cortelli</h3></div><div class="js-work-strip profile--work_container" data-work-id="51822986"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/51822986/Brain_dysfunction_in_COVID_19_and_CAR_T_therapy_cytokine_storm_associated_encephalopathy"><img alt="Research paper thumbnail of Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy" class="work-thumbnail" src="https://attachments.academia-assets.com/69374412/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/51822986/Brain_dysfunction_in_COVID_19_and_CAR_T_therapy_cytokine_storm_associated_encephalopathy">Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/UmbertoPensato">Umberto Pensato</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PietroCortelli">Pietro Cortelli</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Many neurological manifestations are associated with COVID-19, including a distinct fo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Many neurological manifestations are associated with COVID-19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID-19 patients. Cytokine storm is also associated with immune effector cell-associated neurotoxicity syndrome (ICANS), a complication of chimeric antigen receptor T-cell (CAR-T) therapy, a highly effective treatment for refractory hematological malignancies. We investigated whether COVID-19-related encephalopathy, ICANS, and other encephalopathies associated with cytokine storm, share clinical and investigative findings. Methods: Narrative literature review. Results: Comparisons between COVID-19-related encephalopathy and ICANS revealed several overlapping features. Clinically, these included dysexecutive syndrome, language disturbances, akinetic mutism and delirium. EEG showed a prevalence of frontal abnormalities. Brain MRI was often unrevealing. CSF elevated cytokine levels have been reported. A direct correlation between cytokine storm intensity and severity of neurological manifestations has been shown for both conditions. Clinical recovery occurred spontaneously or following immunotherapies in most of the patients. Similar clinical and investigative features were also reported in other encephalopathies associated with cytokine storm, such as hemophagocytic lymphohistiocytosis, sepsis, and febrile infection-associated encephalopathies. Interpretation: COVID-19-related encephalopathy and ICANS are characterized by a predominant electro-clinical frontal lobe dysfunction and share several features with other encephalopathies associated with cytokine storm, which may represent the common denominator of a clinical spectrum of neurological disorders. Therefore, we propose a unifying definition of cytokine storm-associated encephalopathy (CySE), and its diagnostic criteria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1eebc3e98a09a3ed0f9550920157cdfb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69374412,"asset_id":51822986,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69374412/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="51822986"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="51822986"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 51822986; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=51822986]").text(description); $(".js-view-count[data-work-id=51822986]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 51822986; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='51822986']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 51822986, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1eebc3e98a09a3ed0f9550920157cdfb" } } $('.js-work-strip[data-work-id=51822986]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":51822986,"title":"Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy","translated_title":"","metadata":{"doi":"10.1002/acn3.51348","abstract":"Objective: Many neurological manifestations are associated with COVID-19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID-19 patients. Cytokine storm is also associated with immune effector cell-associated neurotoxicity syndrome (ICANS), a complication of chimeric antigen receptor T-cell (CAR-T) therapy, a highly effective treatment for refractory hematological malignancies. We investigated whether COVID-19-related encephalopathy, ICANS, and other encephalopathies associated with cytokine storm, share clinical and investigative findings. Methods: Narrative literature review. Results: Comparisons between COVID-19-related encephalopathy and ICANS revealed several overlapping features. Clinically, these included dysexecutive syndrome, language disturbances, akinetic mutism and delirium. EEG showed a prevalence of frontal abnormalities. Brain MRI was often unrevealing. CSF elevated cytokine levels have been reported. A direct correlation between cytokine storm intensity and severity of neurological manifestations has been shown for both conditions. 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src="https://attachments.academia-assets.com/42242109/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17634516/Clinical_and_brain_bioenergetics_improvement_with_idebenone_in_a_patient_with_Lebers_hereditary_optic_neuropathy_a_clinical_and_31P_MRS_study">Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoccoLiguori">Rocco Liguori</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PietroCortelli">Pietro Cortelli</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PieroBarboni">Piero Barboni</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study in vivo brain and muscle bi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study in vivo brain and muscle bioenergetics in a male patient with Leber&amp;#39;s hereditary optic neuropathy (LHON) and mtDNA mutation at 11,778 bp who developed spastic paraparesis with white matter lesions on brain MR imaging. The study was performed before and during treatment with idebenone (135 mg t.i.d.) and after withdrawal. Clinical amelioration and worsening were associated with parallel changes in brain and skeletal muscle bioenergetics following the administration or withdrawal of idebenone. Reversal of paraparesis by idebenone was paralleled by normalization of 31P-MRS, serum lactate and central motor conduction. Extra-ocular neurological dysfunction in LHON may be amenable to treatment by appropriate quinones.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1026bfb12692db310ae54ec3e01d2ac4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42242109,"asset_id":17634516,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42242109/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17634516"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17634516"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17634516; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17634516]").text(description); $(".js-view-count[data-work-id=17634516]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17634516; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17634516']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17634516, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1026bfb12692db310ae54ec3e01d2ac4" } } $('.js-work-strip[data-work-id=17634516]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17634516,"title":"Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study","translated_title":"","metadata":{"abstract":"We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study in vivo brain and muscle bioenergetics in a male patient with Leber\u0026amp;#39;s hereditary optic neuropathy (LHON) and mtDNA mutation at 11,778 bp who developed spastic paraparesis with white matter lesions on brain MR imaging. 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type I</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A case of Chiari malformation type I with orthostatic hypotension and sleep apnea leading to conv...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A case of Chiari malformation type I with orthostatic hypotension and sleep apnea leading to convulsive attacks is presented.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735353"><a class="js-profile-work-strip-edit-button" 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735348/Central_alveolar_hypoventilation_Ondines_curse_treated_with_negative_pressure_ventilation">Central alveolar hypoventilation (Ondine's curse) treated with negative pressure ventilation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal poly...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal polysomnographic recordings to assess the efficacy of negative pressure ventilation (NPV) administered by pneumowrap. The NPV successfully prevented hypoxia during most of the recording time; however, a sudden severe hypoxic episode not related to an apnoea occurred during a recording night with NPV. This made home use advisable together with an ear oximeter fitted with an alarm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735348"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735348"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735348; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735348]").text(description); $(".js-view-count[data-work-id=12735348]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735348; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735348']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735348, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735348]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735348,"title":"Central alveolar hypoventilation (Ondine's curse) treated with negative pressure ventilation","translated_title":"","metadata":{"abstract":"A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal polysomnographic recordings to assess the efficacy of negative pressure ventilation (NPV) administered by pneumowrap. The NPV successfully prevented hypoxia during most of the recording time; however, a sudden severe hypoxic episode not related to an apnoea occurred during a recording night with NPV. This made home use advisable together with an ear oximeter fitted with an alarm."},"translated_abstract":"A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal polysomnographic recordings to assess the efficacy of negative pressure ventilation (NPV) administered by pneumowrap. The NPV successfully prevented hypoxia during most of the recording time; however, a sudden severe hypoxic episode not related to an apnoea occurred during a recording night with NPV. This made home use advisable together with an ear oximeter fitted with an alarm.","internal_url":"https://www.academia.edu/12735348/Central_alveolar_hypoventilation_Ondines_curse_treated_with_negative_pressure_ventilation","translated_internal_url":"","created_at":"2015-06-01T15:17:45.612-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Central_alveolar_hypoventilation_Ondines_curse_treated_with_negative_pressure_ventilation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[],"research_interests":[{"id":276766,"name":"Polysomnography","url":"https://www.academia.edu/Documents/in/Polysomnography"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735347"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735347/A_multinational_investigation_of_the_impact_of_subcutaneous_sumatriptan_IV_Patient_satisfaction"><img alt="Research paper thumbnail of A multinational investigation of the impact of subcutaneous sumatriptan. IV: Patient satisfaction" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735347/A_multinational_investigation_of_the_impact_of_subcutaneous_sumatriptan_IV_Patient_satisfaction">A multinational investigation of the impact of subcutaneous sumatriptan. IV: Patient satisfaction</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This report describes the design, methods and clinical results of a prospective sequential multin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks&amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. These clinical results, which are consistent with those reported in randomised blinded studies of subcutaneous sumatriptan, suggest that relief of migraine symptoms occurs more often, and in less time, in patients receiving subcutaneous sumatriptan rather than customary therapy as their primary medication.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735347"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735347"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735347; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735347]").text(description); $(".js-view-count[data-work-id=12735347]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735347; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735347']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735347, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735347]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735347,"title":"A multinational investigation of the impact of subcutaneous sumatriptan. IV: Patient satisfaction","translated_title":"","metadata":{"abstract":"This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks\u0026amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. These clinical results, which are consistent with those reported in randomised blinded studies of subcutaneous sumatriptan, suggest that relief of migraine symptoms occurs more often, and in less time, in patients receiving subcutaneous sumatriptan rather than customary therapy as their primary medication."},"translated_abstract":"This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks\u0026amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735346]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735346,"title":"POWER SPECTRAL-ANALYSIS REVEALS SYMPATHETIC HYPERACTIVITY AS AN EARLY FEATURE OF FATAL FAMILIAL INSOMNIA (FFI)","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735346/POWER_SPECTRAL_ANALYSIS_REVEALS_SYMPATHETIC_HYPERACTIVITY_AS_AN_EARLY_FEATURE_OF_FATAL_FAMILIAL_INSOMNIA_FFI_","translated_internal_url":"","created_at":"2015-06-01T15:17:45.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"POWER_SPECTRAL_ANALYSIS_REVEALS_SYMPATHETIC_HYPERACTIVITY_AS_AN_EARLY_FEATURE_OF_FATAL_FAMILIAL_INSOMNIA_FFI_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735345"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735345/A_Multinational_Investigation_of_the_Impact_of_Subcutaneous_Sumatriptan"><img alt="Research paper thumbnail of A Multinational Investigation of the Impact of Subcutaneous Sumatriptan" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735345/A_Multinational_Investigation_of_the_Impact_of_Subcutaneous_Sumatriptan">A Multinational Investigation of the Impact of Subcutaneous Sumatriptan</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This report describes the design, methods and clinical results of a prospective sequential multin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks&amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. These clinical results, which are consistent with those reported in randomised blinded studies of subcutaneous sumatriptan, suggest that relief of migraine symptoms occurs more often, and in less time, in patients receiving subcutaneous sumatriptan rather than customary therapy as their primary medication.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735345"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735345"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735345; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735345]").text(description); $(".js-view-count[data-work-id=12735345]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735345; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735345']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735345, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735345]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735345,"title":"A Multinational Investigation of the Impact of Subcutaneous Sumatriptan","translated_title":"","metadata":{"abstract":"This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. 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Our preliminary data indicate that obesity is associated with a diurnal thermogenic handicap which could play a role in favoring weight gain by lowering wholebody energy expenditure.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Chronobiology International","grobid_abstract_attachment_id":45972867},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735339/Evidence_of_a_diurnal_thermogenic_handicap_in_obesity","translated_internal_url":"","created_at":"2015-06-01T15:17:42.461-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":45972867,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972867/thumbnails/1.jpg","file_name":"Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w.pdf","download_url":"https://www.academia.edu/attachments/45972867/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evidence_of_a_diurnal_thermogenic_handic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972867/Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DEvidence_of_a_diurnal_thermogenic_handic.pdf\u0026Expires=1732809398\u0026Signature=HPhyYdRr2Qfg~K~WyuEMF3Q~vQJf6wBH-ZENv7wCo8I2R2P0YELKWsntyBIhpb6PDCWXgkbV8kwXZCPSiDLy9wMtEPq7SaoSbuXcnhZJAnmuehkWx8CB6kv0IECQxmOOEO-6l1KM~1IoUKIYlBQl3bWyAOeycpsLO0uu13k8NGadtboAEhThK0qdONV9eD~c2hZTIwBEtpHklj93gPC~dPzTy1e-MmoUwNF1VC9m5-RYbmttIXCfWTI4tmClHyGqzCNz5vMRx5cx7DhMKzoloyB9An0tG956iRucYxhn5rZPzW6hHHCusyRA797i116qrrjgmtYJVOcB186auwCymw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evidence_of_a_diurnal_thermogenic_handicap_in_obesity","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[{"id":45972867,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972867/thumbnails/1.jpg","file_name":"Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w.pdf","download_url":"https://www.academia.edu/attachments/45972867/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evidence_of_a_diurnal_thermogenic_handic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972867/Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DEvidence_of_a_diurnal_thermogenic_handic.pdf\u0026Expires=1732809398\u0026Signature=HPhyYdRr2Qfg~K~WyuEMF3Q~vQJf6wBH-ZENv7wCo8I2R2P0YELKWsntyBIhpb6PDCWXgkbV8kwXZCPSiDLy9wMtEPq7SaoSbuXcnhZJAnmuehkWx8CB6kv0IECQxmOOEO-6l1KM~1IoUKIYlBQl3bWyAOeycpsLO0uu13k8NGadtboAEhThK0qdONV9eD~c2hZTIwBEtpHklj93gPC~dPzTy1e-MmoUwNF1VC9m5-RYbmttIXCfWTI4tmClHyGqzCNz5vMRx5cx7DhMKzoloyB9An0tG956iRucYxhn5rZPzW6hHHCusyRA797i116qrrjgmtYJVOcB186auwCymw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":150,"name":"Chronobiology","url":"https://www.academia.edu/Documents/in/Chronobiology"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":100336,"name":"Body Composition","url":"https://www.academia.edu/Documents/in/Body_Composition"},{"id":180715,"name":"Body temperature regulation","url":"https://www.academia.edu/Documents/in/Body_temperature_regulation"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index"},{"id":240716,"name":"Body Temperature","url":"https://www.academia.edu/Documents/in/Body_Temperature"},{"id":380006,"name":"Rest","url":"https://www.academia.edu/Documents/in/Rest"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":1141692,"name":"Weight Gain","url":"https://www.academia.edu/Documents/in/Weight_Gain"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735338"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735338/REM_behaviour_disorder_and_neurodegenerative_diseases"><img alt="Research paper thumbnail of REM behaviour disorder and neurodegenerative diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/45972861/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735338/REM_behaviour_disorder_and_neurodegenerative_diseases">REM behaviour disorder and neurodegenerative diseases</a></div><div class="wp-workCard_item"><span>Sleep Medicine</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0f537cf6a0552d14a858766b6c22eabd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45972861,"asset_id":12735338,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45972861/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735338"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735338"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735338; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0f537cf6a0552d14a858766b6c22eabd" } } $('.js-work-strip[data-work-id=12735338]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735338,"title":"REM behaviour disorder and neurodegenerative diseases","translated_title":"","metadata":{"grobid_abstract":"Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia characterized by enactment of dream content during REM sleep associated with loss of muscle atonia. RBD can be either idiopathic or secondary to drugs or other diseases. The best recognized association is with neurodegenerative diseases, namely alpha-synucleinopathies. RBD may represent the first feature of neurodegeneration and can be considered an early marker of these disorders. This review describes the main clinical, pathogenetic, and therapeutic features of RBD, pointing to its association with neurodegenerative diseases and emphasizing the clinical and prognostic implications.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Sleep Medicine","grobid_abstract_attachment_id":45972861},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735338/REM_behaviour_disorder_and_neurodegenerative_diseases","translated_internal_url":"","created_at":"2015-06-01T15:17:42.170-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":45972861,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972861/thumbnails/1.jpg","file_name":"REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q.pdf","download_url":"https://www.academia.edu/attachments/45972861/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"REM_behaviour_disorder_and_neurodegenera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972861/REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DREM_behaviour_disorder_and_neurodegenera.pdf\u0026Expires=1732809398\u0026Signature=RTJjDqPPe15oHuuGyCmwRkx0~750CuUUqq9XfFTof3PvU4DVZ97h057Vmvadk2ubaSTcc7lCCcjUEVR-~tI2-4CJu2g2Af4ZeuMLwQffd2zd~v~3EHwjDlS6AWhaIgDW7fs1tHp~nkN0AQQ8vIfe1Sc1M5mAHXjvarhTL4YBMkNOwRt7cyfrPRax-8p6iV1aytdESVvU7whyaRZb972AwmnRH7lUKBI0zfW~~5MiuMKL51se37IOJ1B8fu596Nu01I3Rxw-ZYTxAdqhpdXrVBz80l61CC8Z9GrFsp1CQ~4a~g-bkyaXOHtKc5POhsdR~6vF2YgIvmzHCdl49LXqi8Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"REM_behaviour_disorder_and_neurodegenerative_diseases","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[{"id":45972861,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972861/thumbnails/1.jpg","file_name":"REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q.pdf","download_url":"https://www.academia.edu/attachments/45972861/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"REM_behaviour_disorder_and_neurodegenera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972861/REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DREM_behaviour_disorder_and_neurodegenera.pdf\u0026Expires=1732809398\u0026Signature=RTJjDqPPe15oHuuGyCmwRkx0~750CuUUqq9XfFTof3PvU4DVZ97h057Vmvadk2ubaSTcc7lCCcjUEVR-~tI2-4CJu2g2Af4ZeuMLwQffd2zd~v~3EHwjDlS6AWhaIgDW7fs1tHp~nkN0AQQ8vIfe1Sc1M5mAHXjvarhTL4YBMkNOwRt7cyfrPRax-8p6iV1aytdESVvU7whyaRZb972AwmnRH7lUKBI0zfW~~5MiuMKL51se37IOJ1B8fu596Nu01I3Rxw-ZYTxAdqhpdXrVBz80l61CC8Z9GrFsp1CQ~4a~g-bkyaXOHtKc5POhsdR~6vF2YgIvmzHCdl49LXqi8Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":8940,"name":"Multiple System Atrophy","url":"https://www.academia.edu/Documents/in/Multiple_System_Atrophy"},{"id":14498,"name":"Sleep Medicine","url":"https://www.academia.edu/Documents/in/Sleep_Medicine"},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":327712,"name":"REM sleep behavior disorder","url":"https://www.academia.edu/Documents/in/REM_sleep_behavior_disorder"},{"id":527780,"name":"Neurodegenerative Disease","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Disease"},{"id":592786,"name":"Rem Sleep","url":"https://www.academia.edu/Documents/in/Rem_Sleep"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735337"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735337/Lack_of_association_between_five_serotonin_metabolism_related_genes_and_medication_overuse_headache"><img alt="Research paper thumbnail of Lack of association between five serotonin metabolism-related genes and medication overuse headache" class="work-thumbnail" src="https://attachments.academia-assets.com/45972869/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735337/Lack_of_association_between_five_serotonin_metabolism_related_genes_and_medication_overuse_headache">Lack of association between five serotonin metabolism-related genes and medication overuse headache</a></div><div class="wp-workCard_item"><span>The Journal of Headache and Pain</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="178d85ff55e32ec8d90ac1687e138f44" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45972869,"asset_id":12735337,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45972869/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735337"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735337"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735337; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "178d85ff55e32ec8d90ac1687e138f44" } } $('.js-work-strip[data-work-id=12735337]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735337,"title":"Lack of association between five serotonin metabolism-related genes and medication overuse headache","translated_title":"","metadata":{"grobid_abstract":"Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5HTT), serotonin receptor 1A (5-HT1A), serotonin receptor 1B (5-HT1B), serotonin receptor 2A (5-HT2A) and serotonin receptor 6 (5HT6) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the 5HTT, 5-HT1A, 5HT1B, 5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"The Journal of Headache and Pain","grobid_abstract_attachment_id":45972869},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735337/Lack_of_association_between_five_serotonin_metabolism_related_genes_and_medication_overuse_headache","translated_internal_url":"","created_at":"2015-06-01T15:17:41.844-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":45972869,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972869/thumbnails/1.jpg","file_name":"Lack_of_association_between_five_seroton20160526-21842-1c73333.pdf","download_url":"https://www.academia.edu/attachments/45972869/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Lack_of_association_between_five_seroton.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972869/Lack_of_association_between_five_seroton20160526-21842-1c73333-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DLack_of_association_between_five_seroton.pdf\u0026Expires=1732809398\u0026Signature=K~hbnuB5fRfcDdY4DZMIAfiaOsfAblO1rpGu~h6up3yU~2hBzyPjazKhnezQ2aohJdaFwaJuSGCN8UkQyoHWE3YCt-fhBxtHmngM2WaaFZwpg4cSMCFBaKQ-vfPoHojqe0pcjeujQn04rc48kJMgLBdgsUDg2C4OerpxZ8yJAGgn2ZJWb1wimSbobLd4tvJgbee7-E142ERXsUZ6vTe8cxuQzObnG9DWsyCEeOxelf4gftiwyiNe9s82cWwMYXPMHNvQS4ZEcxdAgyKzM1ARJU9BA337wj~BRzkK4XppFSNzOUTraSMQpdE2VpKOoQ19Cfn0kB1tddKiNQnUxs0L4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Lack_of_association_between_five_serotonin_metabolism_related_genes_and_medication_overuse_headache","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[{"id":45972869,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972869/thumbnails/1.jpg","file_name":"Lack_of_association_between_five_seroton20160526-21842-1c73333.pdf","download_url":"https://www.academia.edu/attachments/45972869/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Lack_of_association_between_five_seroton.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972869/Lack_of_association_between_five_seroton20160526-21842-1c73333-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DLack_of_association_between_five_seroton.pdf\u0026Expires=1732809398\u0026Signature=K~hbnuB5fRfcDdY4DZMIAfiaOsfAblO1rpGu~h6up3yU~2hBzyPjazKhnezQ2aohJdaFwaJuSGCN8UkQyoHWE3YCt-fhBxtHmngM2WaaFZwpg4cSMCFBaKQ-vfPoHojqe0pcjeujQn04rc48kJMgLBdgsUDg2C4OerpxZ8yJAGgn2ZJWb1wimSbobLd4tvJgbee7-E142ERXsUZ6vTe8cxuQzObnG9DWsyCEeOxelf4gftiwyiNe9s82cWwMYXPMHNvQS4ZEcxdAgyKzM1ARJU9BA337wj~BRzkK4XppFSNzOUTraSMQpdE2VpKOoQ19Cfn0kB1tddKiNQnUxs0L4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism"},{"id":51565,"name":"Serotonin","url":"https://www.academia.edu/Documents/in/Serotonin"},{"id":102339,"name":"Serotonin Transporter","url":"https://www.academia.edu/Documents/in/Serotonin_Transporter"},{"id":125069,"name":"Genetic Association Studies","url":"https://www.academia.edu/Documents/in/Genetic_Association_Studies"},{"id":129428,"name":"Drug Addiction","url":"https://www.academia.edu/Documents/in/Drug_Addiction"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":306990,"name":"Gene Polymorphism","url":"https://www.academia.edu/Documents/in/Gene_Polymorphism"},{"id":312279,"name":"Serotonin Receptors","url":"https://www.academia.edu/Documents/in/Serotonin_Receptors"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype"},{"id":735504,"name":"Genetic Association","url":"https://www.academia.edu/Documents/in/Genetic_Association"},{"id":1484871,"name":"Pain Threshold","url":"https://www.academia.edu/Documents/in/Pain_Threshold"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="2995672" id="papers"><div class="js-work-strip profile--work_container" data-work-id="51822986"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/51822986/Brain_dysfunction_in_COVID_19_and_CAR_T_therapy_cytokine_storm_associated_encephalopathy"><img alt="Research paper thumbnail of Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy" class="work-thumbnail" src="https://attachments.academia-assets.com/69374412/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/51822986/Brain_dysfunction_in_COVID_19_and_CAR_T_therapy_cytokine_storm_associated_encephalopathy">Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/UmbertoPensato">Umberto Pensato</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PietroCortelli">Pietro Cortelli</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Many neurological manifestations are associated with COVID-19, including a distinct fo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Many neurological manifestations are associated with COVID-19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID-19 patients. Cytokine storm is also associated with immune effector cell-associated neurotoxicity syndrome (ICANS), a complication of chimeric antigen receptor T-cell (CAR-T) therapy, a highly effective treatment for refractory hematological malignancies. We investigated whether COVID-19-related encephalopathy, ICANS, and other encephalopathies associated with cytokine storm, share clinical and investigative findings. Methods: Narrative literature review. Results: Comparisons between COVID-19-related encephalopathy and ICANS revealed several overlapping features. Clinically, these included dysexecutive syndrome, language disturbances, akinetic mutism and delirium. EEG showed a prevalence of frontal abnormalities. Brain MRI was often unrevealing. CSF elevated cytokine levels have been reported. A direct correlation between cytokine storm intensity and severity of neurological manifestations has been shown for both conditions. Clinical recovery occurred spontaneously or following immunotherapies in most of the patients. Similar clinical and investigative features were also reported in other encephalopathies associated with cytokine storm, such as hemophagocytic lymphohistiocytosis, sepsis, and febrile infection-associated encephalopathies. Interpretation: COVID-19-related encephalopathy and ICANS are characterized by a predominant electro-clinical frontal lobe dysfunction and share several features with other encephalopathies associated with cytokine storm, which may represent the common denominator of a clinical spectrum of neurological disorders. Therefore, we propose a unifying definition of cytokine storm-associated encephalopathy (CySE), and its diagnostic criteria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1eebc3e98a09a3ed0f9550920157cdfb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69374412,"asset_id":51822986,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69374412/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="51822986"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="51822986"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 51822986; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=51822986]").text(description); $(".js-view-count[data-work-id=51822986]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 51822986; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='51822986']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 51822986, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1eebc3e98a09a3ed0f9550920157cdfb" } } $('.js-work-strip[data-work-id=51822986]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":51822986,"title":"Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy","translated_title":"","metadata":{"doi":"10.1002/acn3.51348","abstract":"Objective: Many neurological manifestations are associated with COVID-19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID-19 patients. Cytokine storm is also associated with immune effector cell-associated neurotoxicity syndrome (ICANS), a complication of chimeric antigen receptor T-cell (CAR-T) therapy, a highly effective treatment for refractory hematological malignancies. We investigated whether COVID-19-related encephalopathy, ICANS, and other encephalopathies associated with cytokine storm, share clinical and investigative findings. Methods: Narrative literature review. Results: Comparisons between COVID-19-related encephalopathy and ICANS revealed several overlapping features. Clinically, these included dysexecutive syndrome, language disturbances, akinetic mutism and delirium. EEG showed a prevalence of frontal abnormalities. Brain MRI was often unrevealing. CSF elevated cytokine levels have been reported. A direct correlation between cytokine storm intensity and severity of neurological manifestations has been shown for both conditions. Clinical recovery occurred spontaneously or following immunotherapies in most of the patients. Similar clinical and investigative features were also reported in other encephalopathies associated with cytokine storm, such as hemophagocytic lymphohistiocytosis, sepsis, and febrile infection-associated encephalopathies. Interpretation: COVID-19-related encephalopathy and ICANS are characterized by a predominant electro-clinical frontal lobe dysfunction and share several features with other encephalopathies associated with cytokine storm, which may represent the common denominator of a clinical spectrum of neurological disorders. Therefore, we propose a unifying definition of cytokine storm-associated encephalopathy (CySE), and its diagnostic criteria.","publication_date":{"day":null,"month":null,"year":2021,"errors":{}}},"translated_abstract":"Objective: Many neurological manifestations are associated with COVID-19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID-19 patients. Cytokine storm is also associated with immune effector cell-associated neurotoxicity syndrome (ICANS), a complication of chimeric antigen receptor T-cell (CAR-T) therapy, a highly effective treatment for refractory hematological malignancies. We investigated whether COVID-19-related encephalopathy, ICANS, and other encephalopathies associated with cytokine storm, share clinical and investigative findings. Methods: Narrative literature review. Results: Comparisons between COVID-19-related encephalopathy and ICANS revealed several overlapping features. Clinically, these included dysexecutive syndrome, language disturbances, akinetic mutism and delirium. EEG showed a prevalence of frontal abnormalities. Brain MRI was often unrevealing. CSF elevated cytokine levels have been reported. A direct correlation between cytokine storm intensity and severity of neurological manifestations has been shown for both conditions. Clinical recovery occurred spontaneously or following immunotherapies in most of the patients. Similar clinical and investigative features were also reported in other encephalopathies associated with cytokine storm, such as hemophagocytic lymphohistiocytosis, sepsis, and febrile infection-associated encephalopathies. Interpretation: COVID-19-related encephalopathy and ICANS are characterized by a predominant electro-clinical frontal lobe dysfunction and share several features with other encephalopathies associated with cytokine storm, which may represent the common denominator of a clinical spectrum of neurological disorders. Therefore, we propose a unifying definition of cytokine storm-associated encephalopathy (CySE), and its diagnostic criteria.","internal_url":"https://www.academia.edu/51822986/Brain_dysfunction_in_COVID_19_and_CAR_T_therapy_cytokine_storm_associated_encephalopathy","translated_internal_url":"","created_at":"2021-09-11T02:26:47.694-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":110605685,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":36858835,"work_id":51822986,"tagging_user_id":110605685,"tagged_user_id":110605685,"co_author_invite_id":7298510,"email":"u***1@gmail.com","display_order":1,"name":"Umberto Pensato","title":"Brain dysfunction in COVID-19 and CAR-T therapy: cytokine storm-associated encephalopathy"},{"id":36858836,"work_id":51822986,"tagging_user_id":110605685,"tagged_user_id":212226326,"co_author_invite_id":7298511,"email":"i***2@gmail.com","display_order":2,"name":"Ilaria Cani","title":"Brain 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src="https://attachments.academia-assets.com/42242109/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17634516/Clinical_and_brain_bioenergetics_improvement_with_idebenone_in_a_patient_with_Lebers_hereditary_optic_neuropathy_a_clinical_and_31P_MRS_study">Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoccoLiguori">Rocco Liguori</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PietroCortelli">Pietro Cortelli</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PieroBarboni">Piero Barboni</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study in vivo brain and muscle bi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study in vivo brain and muscle bioenergetics in a male patient with Leber&amp;#39;s hereditary optic neuropathy (LHON) and mtDNA mutation at 11,778 bp who developed spastic paraparesis with white matter lesions on brain MR imaging. The study was performed before and during treatment with idebenone (135 mg t.i.d.) and after withdrawal. Clinical amelioration and worsening were associated with parallel changes in brain and skeletal muscle bioenergetics following the administration or withdrawal of idebenone. Reversal of paraparesis by idebenone was paralleled by normalization of 31P-MRS, serum lactate and central motor conduction. Extra-ocular neurological dysfunction in LHON may be amenable to treatment by appropriate quinones.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1026bfb12692db310ae54ec3e01d2ac4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42242109,"asset_id":17634516,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42242109/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17634516"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17634516"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17634516; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17634516]").text(description); $(".js-view-count[data-work-id=17634516]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17634516; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17634516']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17634516, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1026bfb12692db310ae54ec3e01d2ac4" } } $('.js-work-strip[data-work-id=17634516]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17634516,"title":"Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study","translated_title":"","metadata":{"abstract":"We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study in vivo brain and muscle bioenergetics in a male patient with Leber\u0026amp;#39;s hereditary optic neuropathy (LHON) and mtDNA mutation at 11,778 bp who developed spastic paraparesis with white matter lesions on brain MR imaging. 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type I</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A case of Chiari malformation type I with orthostatic hypotension and sleep apnea leading to conv...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A case of Chiari malformation type I with orthostatic hypotension and sleep apnea leading to convulsive attacks is presented.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735353"><a class="js-profile-work-strip-edit-button" 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735348/Central_alveolar_hypoventilation_Ondines_curse_treated_with_negative_pressure_ventilation">Central alveolar hypoventilation (Ondine's curse) treated with negative pressure ventilation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal poly...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal polysomnographic recordings to assess the efficacy of negative pressure ventilation (NPV) administered by pneumowrap. The NPV successfully prevented hypoxia during most of the recording time; however, a sudden severe hypoxic episode not related to an apnoea occurred during a recording night with NPV. This made home use advisable together with an ear oximeter fitted with an alarm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735348"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735348"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735348; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735348]").text(description); $(".js-view-count[data-work-id=12735348]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735348; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735348']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735348, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735348]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735348,"title":"Central alveolar hypoventilation (Ondine's curse) treated with negative pressure ventilation","translated_title":"","metadata":{"abstract":"A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal polysomnographic recordings to assess the efficacy of negative pressure ventilation (NPV) administered by pneumowrap. The NPV successfully prevented hypoxia during most of the recording time; however, a sudden severe hypoxic episode not related to an apnoea occurred during a recording night with NPV. This made home use advisable together with an ear oximeter fitted with an alarm."},"translated_abstract":"A 22 year old woman with central alveolar hypoventilation (CAH) underwent repeated nocturnal polysomnographic recordings to assess the efficacy of negative pressure ventilation (NPV) administered by pneumowrap. The NPV successfully prevented hypoxia during most of the recording time; however, a sudden severe hypoxic episode not related to an apnoea occurred during a recording night with NPV. This made home use advisable together with an ear oximeter fitted with an alarm.","internal_url":"https://www.academia.edu/12735348/Central_alveolar_hypoventilation_Ondines_curse_treated_with_negative_pressure_ventilation","translated_internal_url":"","created_at":"2015-06-01T15:17:45.612-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Central_alveolar_hypoventilation_Ondines_curse_treated_with_negative_pressure_ventilation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[],"research_interests":[{"id":276766,"name":"Polysomnography","url":"https://www.academia.edu/Documents/in/Polysomnography"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735347"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735347/A_multinational_investigation_of_the_impact_of_subcutaneous_sumatriptan_IV_Patient_satisfaction"><img alt="Research paper thumbnail of A multinational investigation of the impact of subcutaneous sumatriptan. IV: Patient satisfaction" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735347/A_multinational_investigation_of_the_impact_of_subcutaneous_sumatriptan_IV_Patient_satisfaction">A multinational investigation of the impact of subcutaneous sumatriptan. IV: Patient satisfaction</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This report describes the design, methods and clinical results of a prospective sequential multin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks&amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. These clinical results, which are consistent with those reported in randomised blinded studies of subcutaneous sumatriptan, suggest that relief of migraine symptoms occurs more often, and in less time, in patients receiving subcutaneous sumatriptan rather than customary therapy as their primary medication.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735347"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735347"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735347; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735347]").text(description); $(".js-view-count[data-work-id=12735347]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735347; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735347']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735347, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735347]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735347,"title":"A multinational investigation of the impact of subcutaneous sumatriptan. IV: Patient satisfaction","translated_title":"","metadata":{"abstract":"This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks\u0026amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. These clinical results, which are consistent with those reported in randomised blinded studies of subcutaneous sumatriptan, suggest that relief of migraine symptoms occurs more often, and in less time, in patients receiving subcutaneous sumatriptan rather than customary therapy as their primary medication."},"translated_abstract":"This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks\u0026amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735346]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735346,"title":"POWER SPECTRAL-ANALYSIS REVEALS SYMPATHETIC HYPERACTIVITY AS AN EARLY FEATURE OF FATAL FAMILIAL INSOMNIA (FFI)","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735346/POWER_SPECTRAL_ANALYSIS_REVEALS_SYMPATHETIC_HYPERACTIVITY_AS_AN_EARLY_FEATURE_OF_FATAL_FAMILIAL_INSOMNIA_FFI_","translated_internal_url":"","created_at":"2015-06-01T15:17:45.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"POWER_SPECTRAL_ANALYSIS_REVEALS_SYMPATHETIC_HYPERACTIVITY_AS_AN_EARLY_FEATURE_OF_FATAL_FAMILIAL_INSOMNIA_FFI_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735345"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735345/A_Multinational_Investigation_of_the_Impact_of_Subcutaneous_Sumatriptan"><img alt="Research paper thumbnail of A Multinational Investigation of the Impact of Subcutaneous Sumatriptan" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735345/A_Multinational_Investigation_of_the_Impact_of_Subcutaneous_Sumatriptan">A Multinational Investigation of the Impact of Subcutaneous Sumatriptan</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This report describes the design, methods and clinical results of a prospective sequential multin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. Adult patients with moderate to severe migraine initially received customary therapy for migraine episodes for 12 weeks, followed by 24 weeks&amp;amp;amp;amp;amp;#39; treatment with self-administered subcutaneous sumatriptan 6 mg. Demographic, baseline, health-related quality of life and patient satisfaction rating data were collected during visits to the clinic. Data relating to migraine symptoms, migraine therapy, work productivity and non-work activity time were collected on diary cards filled out by the patients. 749 patients were recruited to the study and 637 received at least 1 dose of sumatriptan. Overall, 75.5% of migraines were successfully treated within 2 hours with sumatriptan compared with 31.9% with customary therapy; 36% of patients reported complete relief at 2 hours with sumatriptan treatment compared with 1% of patients receiving customary therapy. 69% of patients successfully treated 70% of their migraines with sumatriptan within 2 hours, compared with 12% of patients with customary therapy. No serious adverse events were reported; 50% of patients reported an adverse event during the 12-week customary therapy phase and 89% of patients during the 24-week sumatriptan phase. These clinical results, which are consistent with those reported in randomised blinded studies of subcutaneous sumatriptan, suggest that relief of migraine symptoms occurs more often, and in less time, in patients receiving subcutaneous sumatriptan rather than customary therapy as their primary medication.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735345"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735345"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735345; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735345]").text(description); $(".js-view-count[data-work-id=12735345]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735345; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735345']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735345, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12735345]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735345,"title":"A Multinational Investigation of the Impact of Subcutaneous Sumatriptan","translated_title":"","metadata":{"abstract":"This report describes the design, methods and clinical results of a prospective sequential multinational (5 countries) study conducted to evaluate the effects of subcutaneous sumatriptan on health-related quality of life, workplace productivity, clinical parameters and patient satisfaction. 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We tested whether diurnal and nocturnal body core temperature (BcT) measured for 20-h differed in nine obese subjects compared with 12 lean healthy controls when studied at rest under strictly controlled conditions. BcT was significantly reduced (0.35 C) in obese subjects only during diurnal hours while during nocturnal hours BcT pattern was identical in the two groups. Our preliminary data indicate that obesity is associated with a diurnal thermogenic handicap which could play a role in favoring weight gain by lowering wholebody energy expenditure.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Chronobiology International","grobid_abstract_attachment_id":45972867},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735339/Evidence_of_a_diurnal_thermogenic_handicap_in_obesity","translated_internal_url":"","created_at":"2015-06-01T15:17:42.461-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":45972867,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972867/thumbnails/1.jpg","file_name":"Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w.pdf","download_url":"https://www.academia.edu/attachments/45972867/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evidence_of_a_diurnal_thermogenic_handic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972867/Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DEvidence_of_a_diurnal_thermogenic_handic.pdf\u0026Expires=1732809398\u0026Signature=HPhyYdRr2Qfg~K~WyuEMF3Q~vQJf6wBH-ZENv7wCo8I2R2P0YELKWsntyBIhpb6PDCWXgkbV8kwXZCPSiDLy9wMtEPq7SaoSbuXcnhZJAnmuehkWx8CB6kv0IECQxmOOEO-6l1KM~1IoUKIYlBQl3bWyAOeycpsLO0uu13k8NGadtboAEhThK0qdONV9eD~c2hZTIwBEtpHklj93gPC~dPzTy1e-MmoUwNF1VC9m5-RYbmttIXCfWTI4tmClHyGqzCNz5vMRx5cx7DhMKzoloyB9An0tG956iRucYxhn5rZPzW6hHHCusyRA797i116qrrjgmtYJVOcB186auwCymw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evidence_of_a_diurnal_thermogenic_handicap_in_obesity","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[{"id":45972867,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972867/thumbnails/1.jpg","file_name":"Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w.pdf","download_url":"https://www.academia.edu/attachments/45972867/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evidence_of_a_diurnal_thermogenic_handic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972867/Evidence_of_a_diurnal_thermogenic_handic20160526-15116-1nh781w-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DEvidence_of_a_diurnal_thermogenic_handic.pdf\u0026Expires=1732809398\u0026Signature=HPhyYdRr2Qfg~K~WyuEMF3Q~vQJf6wBH-ZENv7wCo8I2R2P0YELKWsntyBIhpb6PDCWXgkbV8kwXZCPSiDLy9wMtEPq7SaoSbuXcnhZJAnmuehkWx8CB6kv0IECQxmOOEO-6l1KM~1IoUKIYlBQl3bWyAOeycpsLO0uu13k8NGadtboAEhThK0qdONV9eD~c2hZTIwBEtpHklj93gPC~dPzTy1e-MmoUwNF1VC9m5-RYbmttIXCfWTI4tmClHyGqzCNz5vMRx5cx7DhMKzoloyB9An0tG956iRucYxhn5rZPzW6hHHCusyRA797i116qrrjgmtYJVOcB186auwCymw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":150,"name":"Chronobiology","url":"https://www.academia.edu/Documents/in/Chronobiology"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":100336,"name":"Body Composition","url":"https://www.academia.edu/Documents/in/Body_Composition"},{"id":180715,"name":"Body temperature regulation","url":"https://www.academia.edu/Documents/in/Body_temperature_regulation"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index"},{"id":240716,"name":"Body Temperature","url":"https://www.academia.edu/Documents/in/Body_Temperature"},{"id":380006,"name":"Rest","url":"https://www.academia.edu/Documents/in/Rest"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":1141692,"name":"Weight Gain","url":"https://www.academia.edu/Documents/in/Weight_Gain"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735338"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735338/REM_behaviour_disorder_and_neurodegenerative_diseases"><img alt="Research paper thumbnail of REM behaviour disorder and neurodegenerative diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/45972861/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735338/REM_behaviour_disorder_and_neurodegenerative_diseases">REM behaviour disorder and neurodegenerative diseases</a></div><div class="wp-workCard_item"><span>Sleep Medicine</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0f537cf6a0552d14a858766b6c22eabd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45972861,"asset_id":12735338,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45972861/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735338"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735338"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735338; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0f537cf6a0552d14a858766b6c22eabd" } } $('.js-work-strip[data-work-id=12735338]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735338,"title":"REM behaviour disorder and neurodegenerative diseases","translated_title":"","metadata":{"grobid_abstract":"Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia characterized by enactment of dream content during REM sleep associated with loss of muscle atonia. RBD can be either idiopathic or secondary to drugs or other diseases. The best recognized association is with neurodegenerative diseases, namely alpha-synucleinopathies. RBD may represent the first feature of neurodegeneration and can be considered an early marker of these disorders. This review describes the main clinical, pathogenetic, and therapeutic features of RBD, pointing to its association with neurodegenerative diseases and emphasizing the clinical and prognostic implications.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Sleep Medicine","grobid_abstract_attachment_id":45972861},"translated_abstract":null,"internal_url":"https://www.academia.edu/12735338/REM_behaviour_disorder_and_neurodegenerative_diseases","translated_internal_url":"","created_at":"2015-06-01T15:17:42.170-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":31767894,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":45972861,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972861/thumbnails/1.jpg","file_name":"REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q.pdf","download_url":"https://www.academia.edu/attachments/45972861/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"REM_behaviour_disorder_and_neurodegenera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972861/REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DREM_behaviour_disorder_and_neurodegenera.pdf\u0026Expires=1732809398\u0026Signature=RTJjDqPPe15oHuuGyCmwRkx0~750CuUUqq9XfFTof3PvU4DVZ97h057Vmvadk2ubaSTcc7lCCcjUEVR-~tI2-4CJu2g2Af4ZeuMLwQffd2zd~v~3EHwjDlS6AWhaIgDW7fs1tHp~nkN0AQQ8vIfe1Sc1M5mAHXjvarhTL4YBMkNOwRt7cyfrPRax-8p6iV1aytdESVvU7whyaRZb972AwmnRH7lUKBI0zfW~~5MiuMKL51se37IOJ1B8fu596Nu01I3Rxw-ZYTxAdqhpdXrVBz80l61CC8Z9GrFsp1CQ~4a~g-bkyaXOHtKc5POhsdR~6vF2YgIvmzHCdl49LXqi8Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"REM_behaviour_disorder_and_neurodegenerative_diseases","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":31767894,"first_name":"Pietro","middle_initials":null,"last_name":"Cortelli","page_name":"PietroCortelli","domain_name":"independent","created_at":"2015-06-01T15:14:05.638-07:00","display_name":"Pietro Cortelli","url":"https://independent.academia.edu/PietroCortelli"},"attachments":[{"id":45972861,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45972861/thumbnails/1.jpg","file_name":"REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q.pdf","download_url":"https://www.academia.edu/attachments/45972861/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"REM_behaviour_disorder_and_neurodegenera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45972861/REM_behaviour_disorder_and_neurodegenera20160526-15116-93qq3q-libre.pdf?1464288815=\u0026response-content-disposition=attachment%3B+filename%3DREM_behaviour_disorder_and_neurodegenera.pdf\u0026Expires=1732809398\u0026Signature=RTJjDqPPe15oHuuGyCmwRkx0~750CuUUqq9XfFTof3PvU4DVZ97h057Vmvadk2ubaSTcc7lCCcjUEVR-~tI2-4CJu2g2Af4ZeuMLwQffd2zd~v~3EHwjDlS6AWhaIgDW7fs1tHp~nkN0AQQ8vIfe1Sc1M5mAHXjvarhTL4YBMkNOwRt7cyfrPRax-8p6iV1aytdESVvU7whyaRZb972AwmnRH7lUKBI0zfW~~5MiuMKL51se37IOJ1B8fu596Nu01I3Rxw-ZYTxAdqhpdXrVBz80l61CC8Z9GrFsp1CQ~4a~g-bkyaXOHtKc5POhsdR~6vF2YgIvmzHCdl49LXqi8Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":8940,"name":"Multiple System Atrophy","url":"https://www.academia.edu/Documents/in/Multiple_System_Atrophy"},{"id":14498,"name":"Sleep Medicine","url":"https://www.academia.edu/Documents/in/Sleep_Medicine"},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":327712,"name":"REM sleep behavior disorder","url":"https://www.academia.edu/Documents/in/REM_sleep_behavior_disorder"},{"id":527780,"name":"Neurodegenerative Disease","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Disease"},{"id":592786,"name":"Rem Sleep","url":"https://www.academia.edu/Documents/in/Rem_Sleep"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12735337"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12735337/Lack_of_association_between_five_serotonin_metabolism_related_genes_and_medication_overuse_headache"><img alt="Research paper thumbnail of Lack of association between five serotonin metabolism-related genes and medication overuse headache" class="work-thumbnail" src="https://attachments.academia-assets.com/45972869/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12735337/Lack_of_association_between_five_serotonin_metabolism_related_genes_and_medication_overuse_headache">Lack of association between five serotonin metabolism-related genes and medication overuse headache</a></div><div class="wp-workCard_item"><span>The Journal of Headache and Pain</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="178d85ff55e32ec8d90ac1687e138f44" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45972869,"asset_id":12735337,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45972869/download_file?st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTc5OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12735337"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12735337"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12735337; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12735337]").text(description); $(".js-view-count[data-work-id=12735337]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12735337; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12735337']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12735337, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "178d85ff55e32ec8d90ac1687e138f44" } } $('.js-work-strip[data-work-id=12735337]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12735337,"title":"Lack of association between five serotonin metabolism-related genes and medication overuse headache","translated_title":"","metadata":{"grobid_abstract":"Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5HTT), serotonin receptor 1A (5-HT1A), serotonin receptor 1B (5-HT1B), serotonin receptor 2A (5-HT2A) and serotonin receptor 6 (5HT6) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the 5HTT, 5-HT1A, 5HT1B, 5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"The Journal of Headache and 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