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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>Primary small bowel adenomas and adenocarcinomas—recent advances | Virchows Archiv </title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="Primary small bowel adenomas and adenocarcinomas—recent advances"/> <meta name="twitter:description" content="Virchows Archiv - The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this..."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs00428-018-2400-7/MediaObjects/428_2018_2400_Fig1_HTML.jpg"/> <meta name="journal_id" content="428"/> <meta name="dc.title" content="Primary small bowel adenomas and adenocarcinomas—recent advances"/> <meta name="dc.source" content="Virchows Archiv 2018 473:3"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2018-07-11"/> <meta name="dc.type" content="ReviewPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2018 Springer-Verlag GmbH Germany, part of Springer Nature"/> <meta name="dc.rights" content="2018 Springer-Verlag GmbH Germany, part of Springer Nature"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this site. Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Over recent years, ampullary tumours have become recognised as a form of small bowel carcinoma, distinct from head of pancreas and lower biliary tract tumours. This is reflected in separate TNM systems and increasing interest in separating intestinal from pancreatobiliary subtypes. The recognition of the importance of microsatellite (MSI) status and the advent of molecular pathology has also changed our approach to these neoplasms."/> <meta name="prism.issn" content="1432-2307"/> <meta name="prism.publicationName" content="Virchows Archiv"/> <meta name="prism.publicationDate" content="2018-07-11"/> <meta name="prism.volume" content="473"/> <meta name="prism.number" content="3"/> <meta name="prism.section" content="ReviewPaper"/> <meta name="prism.startingPage" content="265"/> <meta name="prism.endingPage" content="273"/> <meta name="prism.copyright" content="2018 Springer-Verlag GmbH Germany, part of Springer Nature"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1007/s00428-018-2400-7"/> <meta name="prism.doi" content="doi:10.1007/s00428-018-2400-7"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1007/s00428-018-2400-7.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1007/s00428-018-2400-7"/> <meta name="citation_journal_title" content="Virchows Archiv"/> <meta name="citation_journal_abbrev" content="Virchows Arch"/> <meta name="citation_publisher" content="Springer Berlin Heidelberg"/> <meta name="citation_issn" content="1432-2307"/> <meta name="citation_title" content="Primary small bowel adenomas and adenocarcinomas—recent advances"/> <meta name="citation_volume" content="473"/> <meta name="citation_issue" content="3"/> <meta name="citation_publication_date" content="2018/09"/> <meta name="citation_online_date" content="2018/07/11"/> <meta name="citation_firstpage" content="265"/> <meta name="citation_lastpage" content="273"/> <meta name="citation_article_type" content="Review and Perspectives"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1007/s00428-018-2400-7"/> <meta name="DOI" content="10.1007/s00428-018-2400-7"/> <meta name="size" content="273861"/> <meta name="citation_doi" content="10.1007/s00428-018-2400-7"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1007/s00428-018-2400-7&api_key="/> <meta name="description" content="The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive syste"/> <meta name="dc.creator" content="Maguire, Aoife"/> <meta name="dc.creator" content="Sheahan, Kieran"/> <meta name="dc.subject" content="Pathology"/> <meta name="citation_reference" content="citation_journal_title=Ann Epidemiol; citation_title=The epidemiology and pathogenesis of neoplasia in the small intestine; citation_author=D Schottenfeld, JL Beebe-Dimmer, FD Vigneau; citation_volume=19; citation_publication_date=2009; citation_pages=58-69; citation_doi=10.1016/j.annepidem.2008.10.004; citation_id=CR1"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg; citation_title=Small bowel cancer in the United States: changes in epidemiology, treatment and survival over the last 20 years; citation_author=KY Bilimoria, DJ Bentrem, JD Wayne, CY Ko, CL Bennett, MS Talamonti; citation_volume=249; citation_publication_date=2009; citation_pages=63-71; citation_doi=10.1097/SLA.0b013e31818e4641; citation_id=CR2"/> <meta name="citation_reference" content="citation_journal_title=Best Pract Res Clin Gastroenterol; citation_title=Advanced precancerous lesions in the small bowel mucosa; citation_author=RM Genta, LA Feagins; citation_volume=27; citation_publication_date=2013; citation_pages=225-233; citation_doi=10.1016/j.bpg.2013.03.013; citation_id=CR3"/> <meta name="citation_reference" content="citation_journal_title=Cancer; citation_title=Adenomas of the small intestine: a clinicopathologic review of 51 cases and a study of their relationship to carcinoma; citation_author=KH Perzin, MF Bridge; citation_volume=48; citation_publication_date=1981; citation_pages=799-819; citation_doi=10.1002/1097-0142(19810801)48:3<799::AID-CNCR2820480324>3.0.CO;2-Q; citation_id=CR4"/> <meta name="citation_reference" content="citation_journal_title=Gut; citation_title=Prevention and management of duodenal polyps in familial adenomatous polyposis; citation_author=LA Brosens, JJ Keller, GJ Offerhaus, M Goggins, FM Giardiello; citation_volume=54; citation_publication_date=2005; citation_pages=1034-1043; citation_doi=10.1136/gut.2004.053843; citation_id=CR5"/> <meta name="citation_reference" content="Rosty C, Campbell C, Clendenning M, Bettington M, Buchanan DD, Brown IS (2014) Do serrated neoplasms of the small intestine represent a distinctive entity? Pathological findings and molecular alterations in a series of 13 cases. Histopathology 66:333–342"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg Pathol; citation_title=Extra-ampullary duodenal adenocarcinoma; citation_author=T Ushiku, T Arnason, M Fukayama, GY Lauwers; citation_volume=38; citation_publication_date=2014; citation_pages=1484-1493; citation_doi=10.1097/PAS.0000000000000278; citation_id=CR7"/> <meta name="citation_reference" content="citation_journal_title=Int J Color Dis; citation_title=Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg polyposis register; citation_author=M Kadmon, A Tandara, C Herfarth; citation_volume=16; citation_publication_date=2001; citation_pages=63-75; citation_doi=10.1007/s003840100290; citation_id=CR8"/> <meta name="citation_reference" content="citation_journal_title=Int J Clin Exp Pathol; citation_title=Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen’s disease): clinicopathological spectrum with pathogenetic considerations; citation_author=A Agaimy, N Vassos, RS Croner; citation_volume=5; citation_publication_date=2012; citation_pages=852-862; citation_id=CR9"/> <meta name="citation_reference" content="citation_journal_title=Cancer J; citation_title=Inherited colorectal cancer syndromes; citation_author=F Kastrinos, S Syngal; citation_volume=17; citation_publication_date=2011; citation_pages=405-415; citation_doi=10.1097/PPO.0b013e318237e408; citation_id=CR10"/> <meta name="citation_reference" content="citation_journal_title=Cancer Causes Control; citation_title=Incidence of small bowel cancer in the United States and worldwide: geographic, temporal, and racial differences; citation_author=T Haselkorn, AS Whittemore, DE Lilienfeld; citation_volume=16; citation_publication_date=2005; citation_pages=781-787; citation_doi=10.1007/s10552-005-3635-6; citation_id=CR11"/> <meta name="citation_reference" content="citation_journal_title=Cancer Epidemiol Biomark Prev; citation_title=Molecular genetics of small bowel cancer; citation_author=N Arber, AI Neugut, IB Weinstein, P Holt; citation_volume=6; citation_publication_date=1997; citation_pages=745-748; citation_id=CR12"/> <meta name="citation_reference" content="citation_journal_title=Cancer; citation_title=Investigations on the significance of the adenoma-carcinoma sequence in the small bowel; citation_author=F Sellner; citation_volume=66; citation_publication_date=1990; citation_pages=702-715; citation_doi=10.1002/1097-0142(19900815)66:4<702::AID-CNCR2820660419>3.0.CO;2-Z; citation_id=CR13"/> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol; citation_title=Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?; citation_author=T Delaunoit, F Neczyporenko, PJ Limburg, C Erlichman; citation_volume=100; citation_publication_date=2005; citation_pages=703-710; citation_doi=10.1111/j.1572-0241.2005.40605.x; citation_id=CR14"/> <meta name="citation_reference" content="citation_journal_title=Cancer Epidemiol Biomark Prev; citation_title=Risk factors for adenocarcinomas and malignant carcinoids of the small intestine: preliminary findings; citation_author=CC Chen, AI Neugut, H Rotterdam; citation_volume=3; citation_publication_date=1994; citation_pages=205-207; citation_id=CR15"/> <meta name="citation_reference" content="citation_journal_title=World J Gastrointest Oncol; citation_title=Epidemiology of cancer of the small intestine; citation_author=SY Pan, H Morrison; citation_volume=3; citation_publication_date=2011; citation_pages=33-42; citation_doi=10.4251/wjgo.v3.i3.33; citation_id=CR16"/> <meta name="citation_reference" content="citation_journal_title=Lancet; citation_title=Why are small-bowel tumours so rare?; citation_author=AB Lowenfels; citation_volume=1; citation_publication_date=1973; citation_pages=24-26; citation_doi=10.1016/S0140-6736(73)91228-2; citation_id=CR17"/> <meta name="citation_reference" content="citation_journal_title=Cancer Lett; citation_title=Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility; citation_author=LM Sanders, CE Henderson, MY Hong, R Barhoumi, RC Burghardt, RJ Carroll, ND Turner, RS Chapkin, JR Lupton; citation_volume=208; citation_publication_date=2004; citation_pages=155-161; citation_doi=10.1016/j.canlet.2003.12.007; citation_id=CR18"/> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol; citation_title=Small bowel cancer: epidemiological and clinical characteristics from a population-based registry; citation_author=JA DiSario, RW Burt, H Vargas, WP McWhorter; citation_volume=89; citation_publication_date=1994; citation_pages=699-701; citation_id=CR19"/> <meta name="citation_reference" content="citation_journal_title=Am Surg; citation_title=The continuing clinical dilemma of primary tumors of the small intestine; citation_author=DL Ciresi, DJ Scholten; citation_volume=61; citation_publication_date=1995; citation_pages=698-702; citation_id=CR20"/> <meta name="citation_reference" content="Schirmacher P, Buchler MW (2008) Ampullary adenocarcinoma—differentiation matters. BMC Cancer 8(251)"/> <meta name="citation_reference" content="citation_journal_title=Oncol Lett; citation_title=Small bowel adenocarcinoma—terra incognita: a demand for cross-national pooling of data; citation_author=K Schwameis, SF Schoppmann, J Stift, M Schwameis, A Stift; citation_volume=7; citation_publication_date=2014; citation_pages=1613-1617; citation_doi=10.3892/ol.2014.1919; citation_id=CR22"/> <meta name="citation_reference" content="citation_journal_title=Lancet; citation_title=Does bile promote extra-colonic cancer?; citation_author=AB Lowenfels; citation_volume=2; citation_publication_date=1978; citation_pages=239-241; citation_doi=10.1016/S0140-6736(78)91748-8; citation_id=CR23"/> <meta name="citation_reference" content="citation_journal_title=Br J Cancer; citation_title=Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen?; citation_author=RK Ross, NM Hartnett, L Bernstein, BE Henderson; citation_volume=63; citation_publication_date=1991; citation_pages=143-145; citation_doi=10.1038/bjc.1991.29; citation_id=CR24"/> <meta name="citation_reference" content="citation_journal_title=Arch Surg; citation_title=Small-bowel tumors: epidemiologic and clinical characteristics of 1260 cases from the Connecticut Tumor Registry; citation_author=I Hatzaras, JA Palesty, F Abir, P Sullivan, RA Kozol, SJ Dudrick, WE Longo; citation_volume=142; citation_publication_date=2007; citation_pages=229-235; citation_doi=10.1001/archsurg.142.3.229; citation_id=CR25"/> <meta name="citation_reference" content="Bauer RL, Palmer ML, Bauer AM, Nava HR, Douglass HO, Jr. (1994) Adenocarcinoma of the small intestine: 21-year review of diagnosis, treatment, and prognosis. Ann Surg Oncol 1;183–188"/> <meta name="citation_reference" content="citation_journal_title=Cancer; citation_title=Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients; citation_author=BS Dabaja, D Suki, B Pro, M Bonnen, J Ajani; citation_volume=101; citation_publication_date=2004; citation_pages=518-526; citation_doi=10.1002/cncr.20404; citation_id=CR27"/> <meta name="citation_reference" content="citation_journal_title=Arch Surg; citation_title=Primary cancers of the small bowel: analysis of prognostic factors and results of surgical management; citation_author=MS Talamonti, LH Goetz, S Rao, RJ Joehl; citation_volume=137; citation_publication_date=2002; citation_pages=564-570; citation_doi=10.1001/archsurg.137.5.564; citation_id=CR28"/> <meta name="citation_reference" content="citation_journal_title=Cancer; citation_title=The American College of Surgeons commission on cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the national cancer data base, 1985-1995; citation_author=JR Howe, LH Karnell, HR Menck, C Scott-Conner; citation_volume=86; citation_publication_date=1999; citation_pages=2693-2706; citation_doi=10.1002/(SICI)1097-0142(19991215)86:12<2693::AID-CNCR14>3.0.CO;2-U; citation_id=CR29"/> <meta name="citation_reference" content="citation_journal_title=Cancer; citation_title=Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database; citation_author=MJ Overman, CY Hu, RA Wolff, GJ Chang; citation_volume=116; citation_publication_date=2010; citation_pages=5374-5382; citation_doi=10.1002/cncr.25324; citation_id=CR30"/> <meta name="citation_reference" content="citation_journal_title=Familial Cancer; citation_title=Advanced duodenal disease in familial adenomatous polyposis: how frequently should patients be followed up after successful therapy?; citation_author=DC Balmforth, RK Phillips, SK Clark; citation_volume=11; citation_publication_date=2012; citation_pages=553-557; citation_doi=10.1007/s10689-012-9546-2; citation_id=CR31"/> <meta name="citation_reference" content="citation_journal_title=Lancet; citation_title=Upper gastrointestinal cancer in patients with familial adenomatous polyposis; citation_author=AD Spigelman, CB Williams, IC Talbot, P Domizio, RK Phillips; citation_volume=2; citation_publication_date=1989; citation_pages=783-785; citation_doi=10.1016/S0140-6736(89)90840-4; citation_id=CR32"/> <meta name="citation_reference" content="citation_journal_title=World J Gastroenterol; citation_title=Cancer in inflammatory bowel disease; citation_author=J Xie; citation_volume=14; citation_publication_date=2008; citation_pages=378-389; citation_doi=10.3748/wjg.14.378; citation_id=CR33"/> <meta name="citation_reference" content="citation_journal_title=J Crohn’s Colitis; citation_title=Non-colorectal intestinal tract carcinomas in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (ii); citation_author=L Egan, R D’Inca, T Jess, G Pellino, F Carbonnel, B Bokemeyer, M Harbord, P Nunes, J van der Woude, F Selvaggi, J Triantafillidis; citation_volume=8; citation_publication_date=2014; citation_pages=19-30; citation_doi=10.1016/j.crohns.2013.04.009; citation_id=CR34"/> <meta name="citation_reference" content="citation_journal_title=Inflamm Bowel Dis; citation_title=Small bowel adenocarcinomas complicating Crohn’s disease are associated with dysplasia: a pathological and molecular study; citation_author=M Svrcek, G Piton, J Cosnes, L Beaugerie, S Vermeire, K Geboes, A Lemoine, P Cervera, N el-Murr, S Dumont, A Scriva, O Lascols, S Ardizzone, P Fociani, G Savoye, F le Pessot, G Novacek, F Wrba, JF Colombel, E Leteurtre, Y Bouhnik, D Cazals-Hatem, G Cadiot, MD Diebold, JF Rahier, M Delos, JF Fléjou, F Carbonnel; citation_volume=20; citation_publication_date=2014; citation_pages=1584-1592; citation_doi=10.1097/MIB.0000000000000112; citation_id=CR35"/> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol; citation_title=Risk factors associated with small bowel adenocarcinoma in Crohn’s disease: a case-control study; citation_author=G Piton, J Cosnes, E Monnet, L Beaugerie, P Seksik, G Savoye, G Cadiot, B Flourie, P Capelle, P Marteau, M Lemann, JF Colombel, E Khouri, B Bonaz, F Carbonnel; citation_volume=103; citation_publication_date=2008; citation_pages=1730-1736; citation_doi=10.1111/j.1572-0241.2008.01847.x; citation_id=CR36"/> <meta name="citation_reference" content="citation_journal_title=Dis Colon Rectum; citation_title=The risk of cancer in patients with Crohn’s disease; citation_author=AC Roon, G Reese, J Teare, V Constantinides, AW Darzi, PP Tekkis; citation_volume=50; citation_publication_date=2007; citation_pages=839-855; citation_doi=10.1007/s10350-006-0848-z; citation_id=CR37"/> <meta name="citation_reference" content="citation_journal_title=Aliment Pharmacol Ther; citation_title=Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease; citation_author=C Canavan, KR Abrams, J Mayberry; citation_volume=23; citation_publication_date=2006; citation_pages=1097-1104; citation_doi=10.1111/j.1365-2036.2006.02854.x; citation_id=CR38"/> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol; citation_title=Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studies; citation_author=T Jess, M Gamborg, P Matzen, P Munkholm, TI Sorensen; citation_volume=100; citation_publication_date=2005; citation_pages=2724-2729; citation_doi=10.1111/j.1572-0241.2005.00287.x; citation_id=CR39"/> <meta name="citation_reference" content="citation_journal_title=Gastroenterology; citation_title=Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis; citation_author=J Askling, M Linet, G Gridley, TS Halstensen, K Ekstrom, A Ekbom; citation_volume=123; citation_publication_date=2002; citation_pages=1428-1435; citation_doi=10.1053/gast.2002.36585; citation_id=CR40"/> <meta name="citation_reference" content="citation_journal_title=QJM; citation_title=Primary small-bowel malignancy in the UK and its association with coeliac disease; citation_author=PD Howdle, PK Jalal, GK Holmes, RS Houlston; citation_volume=96; citation_publication_date=2003; citation_pages=345-353; citation_doi=10.1093/qjmed/hcg058; citation_id=CR41"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg Oncol; citation_title=Small bowel adenocarcinoma: understaged and undertreated?; citation_author=MB Nicholl, V Ahuja, WC Conway, VD Vu, MS Sim, G Singh; citation_volume=17; citation_publication_date=2010; citation_pages=2728-2732; citation_doi=10.1245/s10434-010-1109-x; citation_id=CR42"/> <meta name="citation_reference" content="Koo DH, Yun SC, Hong YS, Ryu MH, Lee JL, Chang HM, Ryoo BY, Kang YK, Kim TW (2011) Systemic chemotherapy for treatment of advanced small bowel adenocarcinoma with prognostic factor analysis: retrospective study. BMC Cancer 11:205"/> <meta name="citation_reference" content="citation_journal_title=Ann Oncol; citation_title=Chemotherapy of advanced small-bowel adenocarcinoma: a multicenter AGEO study; citation_author=A Zaanan, L Costes, M Gauthier, D Malka, C Locher, E Mitry, D Tougeron, T Lecomte, JM Gornet, I Sobhani, V Moulin, P Afchain, J Taieb, F Bonnetain, T Aparicio; citation_volume=21; citation_publication_date=2010; citation_pages=1786-1793; citation_doi=10.1093/annonc/mdq038; citation_id=CR44"/> <meta name="citation_reference" content="citation_journal_title=BMC Cancer; citation_title=Prognostic factors and treatment outcomes in patients with small bowel adenocarcinoma (SBA): the Royal Marsden Hospital (RMH) experience; citation_author=K Khan, C Peckitt, F Sclafani, D Watkins, S Rao, N Starling, V Jain, S Trivedi, S Stanway, D Cunningham, I Chau; citation_volume=15; citation_issue=15; citation_publication_date=2015; citation_pages=15; citation_doi=10.1186/s12885-015-1014-6; citation_id=CR45"/> <meta name="citation_reference" content="citation_journal_title=Acta Oncol; citation_title=Is there a role for adjuvant therapy in resected adenocarcinoma of the small intestine; citation_author=MJ Overman, S Kopetz, E Lin, JL Abbruzzese, RA Wolff; citation_volume=49; citation_publication_date=2010; citation_pages=474-479; citation_doi=10.3109/02841860903490051; citation_id=CR46"/> <meta name="citation_reference" content="citation_journal_title=Mol Clin Oncol; citation_title=The effects of chemotherapy on primary small bowel cancer: a retrospective multicenter observational study in Japan; citation_author=T Mizushima, H Tamagawa, H Mishima; citation_volume=1; citation_publication_date=2013; citation_pages=820-824; citation_doi=10.3892/mco.2013.150; citation_id=CR47"/> <meta name="citation_reference" content="citation_journal_title=Cancer Investig; citation_title=Retrospective analysis of 119 small bowel adenocarcinoma in Chinese patients; citation_author=XC Guo, ZY Mao, D Su, LJ Wang, TT Zhang, L Bai; citation_volume=32; citation_publication_date=2014; citation_pages=178-183; citation_doi=10.3109/07357907.2014.896013; citation_id=CR48"/> <meta name="citation_reference" content="citation_journal_title=Oncology (Williston Park); citation_title=Adjuvant chemotherapy for small bowel adenocarcinoma after curative surgery; citation_author=DH Koo, SC Yun, YS Hong, MH Ryu, JL Lee, HM Chang, YK Kang, SC Kim, DJ Han, YJ Lee, TW Kim; citation_volume=80; citation_publication_date=2011; citation_pages=208-213; citation_doi=10.1159/000328506; citation_id=CR49"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg; citation_title=A single-institution experience with 491 cases of small bowel adenocarcinoma; citation_author=TR Halfdanarson, RR McWilliams, JH Donohue, JF Quevedo; citation_volume=199; citation_publication_date=2010; citation_pages=797-803; citation_doi=10.1016/j.amjsurg.2009.05.037; citation_id=CR50"/> <meta name="citation_reference" content="Overman MJ (2013) Rare but real: management of small bowel adenocarcinoma. Am Soc Clin Oncol Educ Book 189–193"/> <meta name="citation_reference" content="citation_journal_title=Eur J Cancer; citation_title=Clinical trial designs for rare diseases: studies developed and discussed by the international rare cancers initiative; citation_author=J Bogaerts, MR Sydes, N Keat; citation_volume=51; citation_publication_date=2014; citation_pages=271-281; citation_doi=10.1016/j.ejca.2014.10.027; citation_id=CR52"/> <meta name="citation_reference" content="citation_journal_title=Surgery; citation_title=Survival in ampullary cancer: potential role of different KRAS mutations; citation_author=NP Valsangkar, T Ingkakul, C Correa-Gallego, M Mino-Kenudson, R Masia, KD Lillemoe, CFD Castillo, AL Warshaw, AS Liss, SP Thayer; citation_volume=157; citation_publication_date=2015; citation_pages=260-268; citation_doi=10.1016/j.surg.2014.08.092; citation_id=CR53"/> <meta name="citation_reference" content="citation_journal_title=Am J Clin Pathol; citation_title=Phenotypic and genotypic characterization of carcinomas of the papilla of vater has prognostic and putative therapeutic implications; citation_author=I Kohler, D Jacob, J Budzies, A Lehmann, W Weichert, S Schulz, P Neuhaus, C Röcken; citation_volume=135; citation_publication_date=2011; citation_pages=202-211; citation_doi=10.1309/AJCPCTCUQSYI89YT; citation_id=CR54"/> <meta name="citation_reference" content="citation_journal_title=Pancreas; citation_title=Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas; citation_author=NA Schultz, A Roslind, IJ Christensen, T Horn, E Høgdall, LN Pedersen, M Kruhøffer, F Burcharth, M Wøjdemann, JS Johansen; citation_volume=41; citation_publication_date=2012; citation_pages=759-766; citation_id=CR55"/> <meta name="citation_reference" content="citation_journal_title=Oncogene; citation_title=Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene; citation_author=H Blaker, A Herbay, R Penzel, S Gross, HF Otto; citation_volume=21; citation_issue=1; citation_publication_date=2002; citation_pages=158-164; citation_doi=10.1038/sj.onc.1205041; citation_id=CR56"/> <meta name="citation_reference" content="citation_journal_title=Gut; citation_title=An insight into the genetic pathway of adenocarcinoma of the small intestine; citation_author=JM Wheeler, BF Warren, NJ Mortensen, HC Kim, SC Biddolph, G Elia, NE Beck, GT Williams, NA Shepherd, AC Bateman, WF Bodmer; citation_volume=50; citation_issue=2; citation_publication_date=2002; citation_pages=218-223; citation_doi=10.1136/gut.50.2.218; citation_id=CR57"/> <meta name="citation_reference" content="citation_journal_title=JAMA Oncol; citation_title=Genomic profiling of small-bowel adenocarcinoma; citation_author=AB Schrock, CE Devoe, R McWilliams, J Sun, T Aparicio, PJ Stephens, JS Ross, R Wilson, VA Miller, SM Ali, MJ Overman; citation_volume=3; citation_publication_date=2017; citation_pages=1546-1553; citation_doi=10.1001/jamaoncol.2017.1051; citation_id=CR58"/> <meta name="citation_reference" content="citation_journal_title=Eur J Cancer; citation_title=ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma; citation_author=A Laforest, T Aparicio, A Zaanan, FP Silva, A Didelot, A Desbeaux, D le Corre, L Benhaim, K Pallier, D Aust, S Pistorius, H Blons, M Svrcek, P Laurent-Puig; citation_volume=50; citation_publication_date=2014; citation_pages=1740-1746; citation_doi=10.1016/j.ejca.2014.04.007; citation_id=CR59"/> <meta name="citation_reference" content="citation_journal_title=N Engl J Med; citation_title=PD-1 blockade in tumors with mismatch-repair deficiency; citation_author=DT Le, JN Uram, H Wang; citation_volume=372; citation_publication_date=2015; citation_pages=2509-2520; citation_doi=10.1056/NEJMoa1500596; citation_id=CR60"/> <meta name="citation_reference" content="citation_journal_title=Cancer; citation_title=Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine; citation_author=M Planck, K Ericson, Z Piotrowska, B Halvarsson, E Rambech, M Nilbert; citation_volume=97; citation_publication_date=2003; citation_pages=1551-1557; citation_doi=10.1002/cncr.11197; citation_id=CR61"/> <meta name="citation_reference" content="citation_journal_title=Cancer Lett; citation_title=Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine; citation_author=WM Brueckl, E Heinze, C Milsmann, A Wein, C Koebnick, A Jung, RS Croner, T Brabletz, K Günther, T Kirchner, EG Hahn, W Hohenberger, H Becker, B Reingruber; citation_volume=203; citation_publication_date=2004; citation_pages=181-190; citation_doi=10.1016/j.canlet.2003.08.013; citation_id=CR62"/> <meta name="citation_reference" content="citation_journal_title=Gastrointest Endosc Clin N Am; citation_title=Ampullary adenoma: clinical manifestations, diagnosis, and treatment; citation_author=JA Martin, GB Haber; citation_volume=13; citation_publication_date=2003; citation_pages=649-669; citation_doi=10.1016/S1052-5157(03)00101-6; citation_id=CR63"/> <meta name="citation_reference" content="citation_journal_title=J Clin Gastroenterol; citation_title=Endoscopic ampullectomy: techniques and outcomes; citation_author=R Patel, S Varadarajulu, CM Wilcox; citation_volume=46; citation_publication_date=2012; citation_pages=8-15; citation_doi=10.1097/MCG.0b013e318233a844; citation_id=CR64"/> <meta name="citation_reference" content="citation_journal_title=Gastrointest Endosc; citation_title=Endoscopic snare papillectomy for tumors of the duodenal papillae; citation_author=CL Cheng, S Sherman, EL Fogel, L McHenry, JL Watkins, T Fukushima, TJ Howard, L Lazzell-Pannell, GA Lehman; citation_volume=60; citation_publication_date=2004; citation_pages=757-764; citation_doi=10.1016/S0016-5107(04)02029-2; citation_id=CR65"/> <meta name="citation_reference" content="citation_journal_title=Am J Clin Path; citation_title=The assessmentof specimens procured by endoscopic ampullectomy; citation_author=; citation_volume=132; citation_publication_date=2009; citation_pages=506-531; citation_doi=10.1309/AJCPUZWJ8WA2IHBG; citation_id=CR66"/> <meta name="citation_reference" content="citation_journal_title=Gastrointest Endosc; citation_title=Endoscopic papillectomy for adenomas of the major duodenal papilla (with video); citation_author=J Han, MH Kim; citation_volume=63; citation_publication_date=2006; citation_pages=292-301; citation_doi=10.1016/j.gie.2005.07.022; citation_id=CR67"/> <meta name="citation_reference" content="citation_journal_title=Gastrointest Endosc; citation_title=Endoscopic biopsy has limited accuracy in diagnosis of ampullary tumors; citation_author=K Yamaguchi, M Enjoji, K Kitamura; citation_volume=36; citation_publication_date=1990; citation_pages=588-592; citation_doi=10.1016/S0016-5107(90)71170-4; citation_id=CR68"/> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol; citation_title=Factors predictive of malignancy and endoscopic resectability in ampullary neoplasia; citation_author=M Kahaleh, VM Shami, A Brock, MR Conaway, C Yoshida, CA Moskaluk, RB Adams, J Tokar, P Yeaton; citation_volume=99; citation_publication_date=2004; citation_pages=2335-2339; citation_doi=10.1111/j.1572-0241.2004.40391.x; citation_id=CR69"/> <meta name="citation_reference" content="citation_journal_title=Curr Opin Gastroenterol; citation_title=Ampullary cancer; citation_author=S Heinrich, PA Clavien; citation_volume=26; citation_publication_date=2010; citation_pages=280-285; citation_doi=10.1097/MOG.0b013e3283378eb0; citation_id=CR70"/> <meta name="citation_reference" content="citation_journal_title=Gut Liver; citation_title=Endoscopic papillectomy for benign ampullary neoplasms: how can treatment outcome be predicted?; citation_author=DW Ahn, JK Ryu, J Kim, WJ Yoon, SH Lee, YT Kim, YB Yoon; citation_volume=7; citation_publication_date=2013; citation_pages=239-245; citation_doi=10.5009/gnl.2013.7.2.239; citation_id=CR71"/> <meta name="citation_reference" content="citation_journal_title=World J Gastroenterol; citation_title=Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas; citation_author=LC Azih, BL Broussard, MA Phadnis, MJ Heslin, MA Eloubeidi, S Varadarajulu, JP Arnoletti; citation_volume=19; citation_publication_date=2013; citation_pages=511-515; citation_doi=10.3748/wjg.v19.i4.511; citation_id=CR72"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg Pathol; citation_title=The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater; citation_author=DC Ang, J Shia, LH Tang, N Katabi, DS Klimstra; citation_volume=38; citation_publication_date=2014; citation_pages=1371-1379; citation_doi=10.1097/PAS.0000000000000230; citation_id=CR73"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg Pathol; citation_title=Immunohistochemical classification of ampullary carcinomas: critical reappraisal fails to confirm prognostic relevance for recently proposed panels, and highlights MUC5AC as a strong prognosticator; citation_author=Y Xue, MD Reid, S Balci, B Quigley, T Muraki, B Memis, J Xia, E Hacihasanoglu, G Bedolla, B Pehlivanoglu, GE Kim, T Tajiri, N Ohike, R Aneja, AM Krasinskas, V Adsay; citation_volume=41; citation_publication_date=2017; citation_pages=865-876; citation_doi=10.1097/PAS.0000000000000863; citation_id=CR74"/> <meta name="citation_reference" content="citation_journal_title=Histopathology; citation_title=Ampullary cancer—a separate clinical entity?; citation_author=I Perysinakis, I Margaris, G Kouraklis; citation_volume=64; citation_publication_date=2014; citation_pages=759-768; citation_doi=10.1111/his.12324; citation_id=CR75"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg Pathol; citation_title=Ampullary region carcinomas: definition and site specific classification with delineation of four clinicopathologically and prognostically distinct subsets in an analysis of 249 cases; citation_author=V Adsay, N Ohike, T Tajiri, GE Kim, A Krasinskas, S Balci, P Bagci, O Basturk, S Bandyopadhyay, KT Jang, DA Kooby, SK Maithel, J Sarmiento, CA Staley, RS Gonzalez, SY Kong, M Goodman; citation_volume=36; citation_publication_date=2012; citation_pages=1592-1608; citation_doi=10.1097/PAS.0b013e31826399d8; citation_id=CR76"/> <meta name="citation_reference" content="citation_journal_title=Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver; citation_title=Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment; citation_author=T Aparicio, A Zaanan, M Svrcek; citation_volume=46; citation_publication_date=2014; citation_pages=97-104; citation_doi=10.1016/j.dld.2013.04.013; citation_id=CR77"/> <meta name="citation_reference" content="Bronsert P, Kohler I, Werner M, Makowiec F, Kuesters S, Hoeppner J, Hopt UT, Keck T, Bausch D, Wellner UF (2013) Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin. BMC Cancer 13(428)"/> <meta name="citation_reference" content="citation_journal_title=J Am Coll Surg; citation_title=Tumors of the ampulla of vater: histopathologic classification and predictors of survival; citation_author=JT Carter, JP Grenert, L Rubenstein, L Stewart, LW Way; citation_volume=207; citation_publication_date=2008; citation_pages=210-218; citation_doi=10.1016/j.jamcollsurg.2008.01.028; citation_id=CR79"/> <meta name="citation_reference" content="citation_journal_title=J Clin Oncol; citation_title=Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater; citation_author=DK Chang, NB Jamieson, AL Johns, CJ Scarlett, M Pajic, A Chou, M Pinese, JL Humphris, MD Jones, C Toon, AM Nagrial, LA Chantrill, VT Chin, AV Pinho, I Rooman, MJ Cowley, J Wu, RS Mead, EK Colvin, JS Samra, V Corbo, C Bassi, M Falconi, RT Lawlor, S Crippa, N Sperandio, S Bersani, EJ Dickson, MAA Mohamed, KA Oien, AK Foulis, EA Musgrove, RL Sutherland, JG Kench, CR Carter, AJ Gill, A Scarpa, CJ McKay, AV Biankin; citation_volume=31; citation_publication_date=2013; citation_pages=1348-1356; citation_doi=10.1200/JCO.2012.46.8868; citation_id=CR80"/> <meta name="citation_reference" content="citation_journal_title=J Surg Oncol; citation_title=Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer; citation_author=WS Kim, DW Choi, SH Choi, JS Heo, DD You, HG Lee; citation_volume=105; citation_publication_date=2012; citation_pages=266-272; citation_doi=10.1002/jso.22090; citation_id=CR81"/> <meta name="citation_reference" content="citation_journal_title=Jpn J Cancer Res; citation_title=Different clinicopathologic findings in two histologic types of carcinoma of papilla of vater; citation_author=W Kimura, N Futakawa, S Yamagata, Y Wada, A Kuroda, T Muto, Y Esaki; citation_volume=85; citation_publication_date=1994; citation_pages=161-166; citation_doi=10.1111/j.1349-7006.1994.tb02077.x; citation_id=CR82"/> <meta name="citation_reference" content="citation_journal_title=Hepato-Gastroenterology; citation_title=The clinicopathologic and immunohistochemical characteristics of ampulla of vater carcinoma: the intestinal type is associated with a better prognosis; citation_author=YH Roh, YH Kim, HW Lee, SJ Kim, MS Roh, JS Jeong, GJ Jung; citation_volume=54; citation_publication_date=2007; citation_pages=1641-1644; citation_id=CR83"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg Oncol; citation_title=Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?; citation_author=A Westgaard, E Pomianowska, OP Clausen, IP Gladhaug; citation_volume=20; citation_publication_date=2013; citation_pages=430-439; citation_doi=10.1245/s10434-012-2603-0; citation_id=CR84"/> <meta name="citation_reference" content="Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OPF, Gladhaug IP (2008) Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer 8(170)"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg Pathol; citation_title=Carcinoma of the ampulla of vater: comparative histologic/immunohistochemical classification and follow-up; citation_author=H Zhou, N Schaefer, M Wolff, HP Fischer; citation_volume=28; citation_publication_date=2004; citation_pages=875-882; citation_doi=10.1097/00000478-200407000-00005; citation_id=CR86"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg; citation_title=Factors predictive of survival in ampullary carcinoma; citation_author=JR Howe, DS Klimstra, RD Moccia, KC Conlon, MF Brennan; citation_volume=228; citation_publication_date=1998; citation_pages=87-94; citation_doi=10.1097/00000658-199807000-00013; citation_id=CR87"/> <meta name="citation_reference" content="citation_journal_title=Br J Cancer; citation_title=Validation of histomolecular classification utilizing histological subtype, muc1, and cdx2 for prognostication of resected ampullary adenocarcinoma; citation_author=A Schueneman, M Goggins, J Ensor, B Saka, N Neishaboori, S Lee, A Maitra, G Varadhachary, N Rezaee, C Wolfgang, V Adsay, H Wang, MJ Overman; citation_volume=113; citation_publication_date=2015; citation_pages=64-68; citation_doi=10.1038/bjc.2015.172; citation_id=CR88"/> <meta name="citation_reference" content="citation_journal_title=Surgery; citation_title=Histomorphologic and molecular phenotypes predict gemcitabine response and overall survival in adenocarcinoma of the ampulla of vater; citation_author=TS Schiergens, S Reu, J Neumann, BW Renz, H Niess, S Boeck, V Heinemann, CJ Bruns, KW Jauch, A Kleespies; citation_volume=158; citation_publication_date=2015; citation_pages=151-161; citation_doi=10.1016/j.surg.2015.02.001; citation_id=CR89"/> <meta name="citation_reference" content="Amin Mb, ed. AJCC cancer staging manual, 2017, Springer"/> <meta name="citation_reference" content="citation_journal_title=Pancreas; citation_title=Long-term survival and recurrence patterns in ampullary cancer; citation_author=P Balachandran, SS Sikora, S Kapoor, N Krishnani, A Kumar, R Saxena, VK Kapoor; citation_volume=32; citation_publication_date=2006; citation_pages=390-395; citation_doi=10.1097/01.mpa.0000220864.80034.63; citation_id=CR91"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg Oncol; citation_title=Predictors for patterns of failure after pancreaticoduodenectomy in ampullary cancer; citation_author=HP Hsu, TM Yang, YH Hsieh, YS Shan, PW Lin; citation_volume=14; citation_publication_date=2007; citation_pages=50-60; citation_doi=10.1245/s10434-006-9136-3; citation_id=CR92"/> <meta name="citation_reference" content="citation_journal_title=J Formos Med Assoc; citation_title=Predictors of recurrence after pancreaticoduodenectomy in ampullary cancer: comparison between non-, early and late recurrence; citation_author=HP Hsu, YS Shan, YH Hsieh, TM Yang, PW Lin; citation_volume=106; citation_publication_date=2007; citation_pages=432-443; citation_doi=10.1016/S0929-6646(09)60292-8; citation_id=CR93"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg Oncol; citation_title=Patterns and predictors of failure after curative resections of carcinoma of the ampulla of vater; citation_author=T Todoroki, N Koike, Y Morishita, T Kawamoto, N Ohkohchi, J Shoda, Y Fukuda, H Takahashi; citation_volume=10; citation_publication_date=2003; citation_pages=1176-1183; citation_doi=10.1245/ASO.2003.07.512; citation_id=CR94"/> <meta name="citation_reference" content="citation_journal_title=J Am Coll Surg; citation_title=Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma; citation_author=RD Kim, PS Kundhal, ID McGilvray; citation_volume=202; citation_publication_date=2006; citation_pages=112-119; citation_doi=10.1016/j.jamcollsurg.2005.08.002; citation_id=CR95"/> <meta name="citation_reference" content="citation_journal_title=J Gastrointes Surg; citation_title=Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis; citation_author=JM Winter, JL Cameron, K Olino, JM Herman, MC de Jong, RH Hruban, CL Wolfgang, F Eckhauser, BH Edil, MA Choti, RD Schulick, TM Pawlik; citation_volume=14; citation_publication_date=2010; citation_pages=379-387; citation_doi=10.1007/s11605-009-1080-7; citation_id=CR96"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg Oncol; citation_title=Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma; citation_author=SM Woo, JK Ryu, SH Lee, JW Yoo, JK Park, YT Kim, JY Jang, SW Kim, GH Kang, YB Yoon; citation_volume=14; citation_publication_date=2007; citation_pages=3195-3201; citation_doi=10.1245/s10434-007-9537-y; citation_id=CR97"/> <meta name="citation_reference" content="citation_journal_title=Surgery; citation_title=Increased number of metastatic lymph nodes in adenocarcinoma of the ampulla of vater as a prognostic factor: a proposal of new nodal classification; citation_author=HJ Kang, SH Eo, SC Kim, KM Park, YJ Lee, SK Lee, E Yu, HJ Cho, SM Hong; citation_volume=155; citation_publication_date=2014; citation_pages=74-84; citation_doi=10.1016/j.surg.2013.08.004; citation_id=CR98"/> <meta name="citation_reference" content="citation_journal_title=Am J Surg Pathol; citation_title=Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas; citation_author=N Ohike, I Coban, GE Kim, O Basturk, T Tajiri, A Krasinskas, S Bandyopadhyay, T Morohoshi, Y Shimada, DA Kooby, CA Staley, M Goodman, N Volkan Adsay; citation_volume=34; citation_publication_date=2010; citation_pages=1417-1424; citation_doi=10.1097/PAS.0b013e3181f0b05a; citation_id=CR99"/> <meta name="citation_reference" content="citation_journal_title=Int J Radiat Oncol Biol Phys; citation_title=Adjuvant therapy for ampullary carcinomas: the mayo clinic experience; citation_author=S Bhatia, RC Miller, MG Haddock, JH Donohue, S Krishnan; citation_volume=66; citation_publication_date=2006; citation_pages=514-519; citation_doi=10.1016/j.ijrobp.2006.04.018; citation_id=CR100"/> <meta name="citation_reference" content="citation_journal_title=Int J Radiat Oncol Biol Phys; citation_title=Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas; citation_author=JH Lee, R Whittington, NN Williams, MF Berry, DJ Vaughn, DG Haller, EF Rosato; citation_volume=47; citation_publication_date=2000; citation_pages=945-953; citation_doi=10.1016/S0360-3016(00)00537-X; citation_id=CR101"/> <meta name="citation_reference" content="citation_journal_title=Int J Radiat Oncol Biol Phys; citation_title=Role of adjuvant chemoradiotherapy for ampulla of vater cancer; citation_author=K Kim, EK Chie, JY Jang, SW Kim, DY Oh, SA Im, TY Kim, YJ Bang, SW Ha; citation_volume=75; citation_publication_date=2009; citation_pages=436-441; citation_doi=10.1016/j.ijrobp.2008.11.067; citation_id=CR102"/> <meta name="citation_reference" content="citation_journal_title=Ann Surg Oncol; citation_title=Carcinoma of the ampulla of vater: patterns of failure following resection and benefit of chemoradiotherapy; citation_author=M Palta, P Patel, G Broadwater, C Willett, J Pepek, D Tyler, SY Zafar, H Uronis, H Hurwitz, R White, B Czito; citation_volume=19; citation_publication_date=2012; citation_pages=1535-1540; citation_doi=10.1245/s10434-011-2117-1; citation_id=CR103"/> <meta name="citation_reference" content="citation_journal_title=Semin Radiat Oncol; citation_title=Defining the role of adjuvant therapy: ampullary and duodenal adenocarcinoma; citation_author=SK Jabbour, D Mulvihill; citation_volume=24; citation_publication_date=2014; citation_pages=85-93; citation_doi=10.1016/j.semradonc.2013.11.001; citation_id=CR104"/> <meta name="citation_reference" content="Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW, European Study Group for Pancreatic Cancer (2012) Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA 308:147–156"/> <meta name="citation_reference" content="citation_journal_title=Mod Pathol; citation_title=Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of erbb2 (her2); citation_author=JF Hechtman, W Liu, J Sadowska, L Zhen, L Borsu, ME Arcila, HH Won, RH Shah, MF Berger, E Vakiani, J Shia, DS Klimstra; citation_volume=28; citation_publication_date=2015; citation_pages=1123-1129; citation_doi=10.1038/modpathol.2015.57; citation_id=CR106"/> <meta name="citation_reference" content="citation_journal_title=Oncotarget; citation_title=Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility; citation_author=MA Alvi, DG McArt, P Kelly, MA Fuchs, M Alderdice, C McCabe, V Bingham, C McGready, S Tripathi, F Emmert-Streib, MB Loughrey, S McQuaid, P Maxwell, PW Hamilton, R Turkington, JA James, RH Wilson, M Salto-Tellez; citation_volume=6; citation_publication_date=2015; citation_pages=20863-20874; citation_doi=10.18632/oncotarget.4576; citation_id=CR107"/> <meta name="citation_author" content="Maguire, Aoife"/> <meta name="citation_author_institution" content="Histopathology Department, St. James’s Hospital, Dublin 2, Ireland"/> <meta name="citation_author" content="Sheahan, Kieran"/> <meta name="citation_author_email" content="k.sheahan@st-vincents.ie"/> <meta name="citation_author_institution" content="Pathology Department, & Centre for Colorectal Disease, UCD Medical School, St. Vincent’s University Hospital, Dublin, Ireland"/> <meta name="format-detection" content="telephone=no"/> <meta name="citation_cover_date" content="2018/09/01"/> <meta property="og:url" content="https://link.springer.com/article/10.1007/s00428-018-2400-7"/> <meta property="og:type" content="article"/> <meta property="og:site_name" content="SpringerLink"/> <meta property="og:title" content="Primary small bowel adenomas and adenocarcinomas—recent advances - Virchows Archiv"/> <meta property="og:description" content="The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this site. Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Over recent years, ampullary tumours have become recognised as a form of small bowel carcinoma, distinct from head of pancreas and lower biliary tract tumours. This is reflected in separate TNM systems and increasing interest in separating intestinal from pancreatobiliary subtypes. The recognition of the importance of microsatellite (MSI) status and the advent of molecular pathology has also changed our approach to these neoplasms."/> <meta property="og:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs00428-018-2400-7/MediaObjects/428_2018_2400_Fig1_HTML.jpg"/> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/oscar-static/img/favicons/darwin/apple-touch-icon-92e819bf8a.png> <link rel="icon" type="image/png" sizes="192x192" href=/oscar-static/img/favicons/darwin/android-chrome-192x192-6f081ca7e5.png> <link rel="icon" type="image/png" sizes="32x32" href=/oscar-static/img/favicons/darwin/favicon-32x32-1435da3e82.png> <link rel="icon" type="image/png" sizes="16x16" href=/oscar-static/img/favicons/darwin/favicon-16x16-ed57f42bd2.png> <link rel="shortcut icon" data-test="shortcut-icon" href=/oscar-static/img/favicons/darwin/favicon-c6d59aafac.ico> <meta name="theme-color" 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Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Over recent years, ampullary tumours have become recognised as a form of small bowel carcinoma, distinct from head of pancreas and lower biliary tract tumours. This is reflected in separate TNM systems and increasing interest in separating intestinal from pancreatobiliary subtypes. 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class="c-breadcrumbs__item" id="breadcrumb2" itemprop="itemListElement" itemscope="" itemtype="https://schema.org/ListItem"> <span itemprop="name">Article</span><meta itemprop="position" content="3"> </li> </ol> </nav> <h1 class="c-article-title" data-test="article-title" data-article-title="">Primary small bowel adenomas and adenocarcinomas—recent advances</h1> <ul class="c-article-identifiers"> <li class="c-article-identifiers__item" data-test="article-category">Review and Perspectives</li> <li class="c-article-identifiers__item"> Published: <time datetime="2018-07-11">11 July 2018</time> </li> </ul> <ul class="c-article-identifiers c-article-identifiers--cite-list"> <li class="c-article-identifiers__item"> <span data-test="journal-volume">Volume 473</span>, pages 265–273, (<span data-test="article-publication-year">2018</span>) </li> <li class="c-article-identifiers__item c-article-identifiers__item--cite"> <a href="#citeas" data-track="click" data-track-action="cite this article" 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class="app-article-masthead__journal-title">Virchows Archiv</span> </a> <a href="https://link.springer.com/journal/428/aims-and-scope" class="app-article-masthead__submission-link" data-track="click_aims_and_scope" data-track-action="aims and scope" data-track-context="article page" data-track-label="link"> Aims and scope <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> <a href="https://www.editorialmanager.com/viar" class="app-article-masthead__submission-link" data-track="click_submit_manuscript" data-track-context="article masthead on springerlink article page" data-track-action="submit manuscript" data-track-label="link"> Submit manuscript <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> </div> </div> </div> </section> <div class="c-article-main u-container u-mt-24 u-mb-32 l-with-sidebar" id="main-content" data-component="article-container"> <main class="u-serif js-main-column" data-track-component="article body"> <div class="c-article-header"> <header> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Aoife-Maguire-Aff1" data-author-popup="auth-Aoife-Maguire-Aff1" data-author-search="Maguire, Aoife">Aoife Maguire</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup> & </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Kieran-Sheahan-Aff2" data-author-popup="auth-Kieran-Sheahan-Aff2" data-author-search="Sheahan, Kieran" data-corresp-id="c1">Kieran Sheahan<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff2">2</a></sup> </li></ul> <div data-test="article-metrics"> <ul class="app-article-metrics-bar u-list-reset"> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-accesses-medium"></use> </svg>1346 <span class="app-article-metrics-bar__label">Accesses</span></p> </li> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-altmetric-medium"></use> </svg>9 <span class="app-article-metrics-bar__label">Altmetric</span></p> </li> <li class="app-article-metrics-bar__item app-article-metrics-bar__item--metrics"> <p class="app-article-metrics-bar__details"><a href="/article/10.1007/s00428-018-2400-7/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Explore all metrics <svg class="u-icon app-article-metrics-bar__arrow-icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a></p> </li> </ul> </div> <div class="u-mt-32"> </div> </header> </div> <div data-article-body="true" data-track-component="article body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p>The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this site. Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Over recent years, ampullary tumours have become recognised as a form of small bowel carcinoma, distinct from head of pancreas and lower biliary tract tumours. This is reflected in separate TNM systems and increasing interest in separating intestinal from pancreatobiliary subtypes. The recognition of the importance of microsatellite (MSI) status and the advent of molecular pathology has also changed our approach to these neoplasms.</p></div></div></section> <div class="c-notes"> <p class="c-notes__text c-status-message--info"> <svg width="24" height="24" focusable="false" role="img" aria-hidden="true" class="c-status-message__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-info-filled-medium"></use> </svg> This is a preview of subscription content, <a id="test-login-banner-link" href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00428-018-2400-7%3Ferror%3Dcookies_not_supported%26code%3D34c15675-dd6f-4cbb-a79e-24664e41bae4" data-track="click" data-track-action="login" data-track-label="link" class="c-preview-message__link">log in via an institution</a> <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon c-external-link__icon"> <use 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id="MagazineFulltextArticleBodySuffix"><section aria-labelledby="Bib1" data-title="References"><div class="c-article-section" id="Bib1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Bib1">References</h2><div class="c-article-section__content" id="Bib1-content"><div data-container-section="references"><ol class="c-article-references" data-track-component="outbound reference" data-track-context="references section"><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="1."><p class="c-article-references__text" id="ref-CR1">Schottenfeld D, Beebe-Dimmer JL, Vigneau FD (2009) The epidemiology and pathogenesis of neoplasia in the small intestine. Ann Epidemiol 19:58–69</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.annepidem.2008.10.004" data-track-item_id="10.1016/j.annepidem.2008.10.004" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.annepidem.2008.10.004" aria-label="Article reference 1" data-doi="10.1016/j.annepidem.2008.10.004">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19064190" aria-label="PubMed reference 1">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792582" aria-label="PubMed Central reference 1">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 1" href="http://scholar.google.com/scholar_lookup?&title=The%20epidemiology%20and%20pathogenesis%20of%20neoplasia%20in%20the%20small%20intestine&journal=Ann%20Epidemiol&doi=10.1016%2Fj.annepidem.2008.10.004&volume=19&pages=58-69&publication_year=2009&author=Schottenfeld%2CD&author=Beebe-Dimmer%2CJL&author=Vigneau%2CFD"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="2."><p class="c-article-references__text" id="ref-CR2">Bilimoria KY, Bentrem DJ, Wayne JD, Ko CY, Bennett CL, Talamonti MS (2009) Small bowel cancer in the United States: changes in epidemiology, treatment and survival over the last 20 years. Ann Surg 249:63–71</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/SLA.0b013e31818e4641" data-track-item_id="10.1097/SLA.0b013e31818e4641" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FSLA.0b013e31818e4641" aria-label="Article reference 2" data-doi="10.1097/SLA.0b013e31818e4641">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19106677" aria-label="PubMed reference 2">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 2" href="http://scholar.google.com/scholar_lookup?&title=Small%20bowel%20cancer%20in%20the%20United%20States%3A%20changes%20in%20epidemiology%2C%20treatment%20and%20survival%20over%20the%20last%2020%20years&journal=Ann%20Surg&doi=10.1097%2FSLA.0b013e31818e4641&volume=249&pages=63-71&publication_year=2009&author=Bilimoria%2CKY&author=Bentrem%2CDJ&author=Wayne%2CJD&author=Ko%2CCY&author=Bennett%2CCL&author=Talamonti%2CMS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="3."><p class="c-article-references__text" id="ref-CR3">Genta RM, Feagins LA (2013) Advanced precancerous lesions in the small bowel mucosa. Best Pract Res Clin Gastroenterol 27:225–233</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.bpg.2013.03.013" data-track-item_id="10.1016/j.bpg.2013.03.013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.bpg.2013.03.013" aria-label="Article reference 3" data-doi="10.1016/j.bpg.2013.03.013">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23809242" aria-label="PubMed reference 3">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 3" href="http://scholar.google.com/scholar_lookup?&title=Advanced%20precancerous%20lesions%20in%20the%20small%20bowel%20mucosa&journal=Best%20Pract%20Res%20Clin%20Gastroenterol&doi=10.1016%2Fj.bpg.2013.03.013&volume=27&pages=225-233&publication_year=2013&author=Genta%2CRM&author=Feagins%2CLA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="4."><p class="c-article-references__text" id="ref-CR4">Perzin KH, Bridge MF (1981) Adenomas of the small intestine: a clinicopathologic review of 51 cases and a study of their relationship to carcinoma. Cancer 48:799–819</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/1097-0142(19810801)48:3<799::AID-CNCR2820480324>3.0.CO;2-Q" data-track-item_id="10.1002/1097-0142(19810801)48:3<799::AID-CNCR2820480324>3.0.CO;2-Q" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2F1097-0142%2819810801%2948%3A3%3C799%3A%3AAID-CNCR2820480324%3E3.0.CO%3B2-Q" aria-label="Article reference 4" data-doi="10.1002/1097-0142(19810801)48:3<799::AID-CNCR2820480324>3.0.CO;2-Q">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7248908" aria-label="PubMed reference 4">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaL3M3jsVaitw%3D%3D" aria-label="CAS reference 4">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 4" href="http://scholar.google.com/scholar_lookup?&title=Adenomas%20of%20the%20small%20intestine%3A%20a%20clinicopathologic%20review%20of%2051%20cases%20and%20a%20study%20of%20their%20relationship%20to%20carcinoma&journal=Cancer&doi=10.1002%2F1097-0142%2819810801%2948%3A3%3C799%3A%3AAID-CNCR2820480324%3E3.0.CO%3B2-Q&volume=48&pages=799-819&publication_year=1981&author=Perzin%2CKH&author=Bridge%2CMF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="5."><p class="c-article-references__text" id="ref-CR5">Brosens LA, Keller JJ, Offerhaus GJ, Goggins M, Giardiello FM (2005) Prevention and management of duodenal polyps in familial adenomatous polyposis. Gut 54:1034–1043</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1136/gut.2004.053843" data-track-item_id="10.1136/gut.2004.053843" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1136%2Fgut.2004.053843" aria-label="Article reference 5" data-doi="10.1136/gut.2004.053843">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15951555" aria-label="PubMed reference 5">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774628" aria-label="PubMed Central reference 5">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD2MzgtleltQ%3D%3D" aria-label="CAS reference 5">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 5" href="http://scholar.google.com/scholar_lookup?&title=Prevention%20and%20management%20of%20duodenal%20polyps%20in%20familial%20adenomatous%20polyposis&journal=Gut&doi=10.1136%2Fgut.2004.053843&volume=54&pages=1034-1043&publication_year=2005&author=Brosens%2CLA&author=Keller%2CJJ&author=Offerhaus%2CGJ&author=Goggins%2CM&author=Giardiello%2CFM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="6."><p class="c-article-references__text" id="ref-CR6">Rosty C, Campbell C, Clendenning M, Bettington M, Buchanan DD, Brown IS (2014) Do serrated neoplasms of the small intestine represent a distinctive entity? Pathological findings and molecular alterations in a series of 13 cases. Histopathology 66:333–342</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="7."><p class="c-article-references__text" id="ref-CR7">Ushiku T, Arnason T, Fukayama M, Lauwers GY (2014) Extra-ampullary duodenal adenocarcinoma. Am J Surg Pathol 38:1484–1493</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/PAS.0000000000000278" data-track-item_id="10.1097/PAS.0000000000000278" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FPAS.0000000000000278" aria-label="Article reference 7" data-doi="10.1097/PAS.0000000000000278">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25310836" aria-label="PubMed reference 7">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 7" href="http://scholar.google.com/scholar_lookup?&title=Extra-ampullary%20duodenal%20adenocarcinoma&journal=Am%20J%20Surg%20Pathol&doi=10.1097%2FPAS.0000000000000278&volume=38&pages=1484-1493&publication_year=2014&author=Ushiku%2CT&author=Arnason%2CT&author=Fukayama%2CM&author=Lauwers%2CGY"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="8."><p class="c-article-references__text" id="ref-CR8">Kadmon M, Tandara A, Herfarth C (2001) Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg polyposis register. Int J Color Dis 16:63–75</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s003840100290" data-track-item_id="10.1007/s003840100290" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s003840100290" aria-label="Article reference 8" data-doi="10.1007/s003840100290">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3M3mtlCntw%3D%3D" aria-label="CAS reference 8">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 8" href="http://scholar.google.com/scholar_lookup?&title=Duodenal%20adenomatosis%20in%20familial%20adenomatous%20polyposis%20coli.%20A%20review%20of%20the%20literature%20and%20results%20from%20the%20Heidelberg%20polyposis%20register&journal=Int%20J%20Color%20Dis&doi=10.1007%2Fs003840100290&volume=16&pages=63-75&publication_year=2001&author=Kadmon%2CM&author=Tandara%2CA&author=Herfarth%2CC"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="9."><p class="c-article-references__text" id="ref-CR9">Agaimy A, Vassos N, Croner RS (2012) Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen’s disease): clinicopathological spectrum with pathogenetic considerations. Int J Clin Exp Pathol 5:852–862 Review</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23119102" aria-label="PubMed reference 9">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484498" aria-label="PubMed Central reference 9">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 9" href="http://scholar.google.com/scholar_lookup?&title=Gastrointestinal%20manifestations%20of%20neurofibromatosis%20type%201%20%28Recklinghausen%E2%80%99s%20disease%29%3A%20clinicopathological%20spectrum%20with%20pathogenetic%20considerations&journal=Int%20J%20Clin%20Exp%20Pathol&volume=5&pages=852-862&publication_year=2012&author=Agaimy%2CA&author=Vassos%2CN&author=Croner%2CRS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="10."><p class="c-article-references__text" id="ref-CR10">Kastrinos F, Syngal S (2011) Inherited colorectal cancer syndromes. Cancer J 17:405–415</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/PPO.0b013e318237e408" data-track-item_id="10.1097/PPO.0b013e318237e408" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FPPO.0b013e318237e408" aria-label="Article reference 10" data-doi="10.1097/PPO.0b013e318237e408">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22157284" aria-label="PubMed reference 10">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240819" aria-label="PubMed Central reference 10">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC38XitVOjtrw%3D" aria-label="CAS reference 10">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 10" href="http://scholar.google.com/scholar_lookup?&title=Inherited%20colorectal%20cancer%20syndromes&journal=Cancer%20J&doi=10.1097%2FPPO.0b013e318237e408&volume=17&pages=405-415&publication_year=2011&author=Kastrinos%2CF&author=Syngal%2CS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="11."><p class="c-article-references__text" id="ref-CR11">Haselkorn T, Whittemore AS, Lilienfeld DE (2005) Incidence of small bowel cancer in the United States and worldwide: geographic, temporal, and racial differences. Cancer Causes Control 16:781–787</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s10552-005-3635-6" data-track-item_id="10.1007/s10552-005-3635-6" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s10552-005-3635-6" aria-label="Article reference 11" data-doi="10.1007/s10552-005-3635-6">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16132788" aria-label="PubMed reference 11">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 11" href="http://scholar.google.com/scholar_lookup?&title=Incidence%20of%20small%20bowel%20cancer%20in%20the%20United%20States%20and%20worldwide%3A%20geographic%2C%20temporal%2C%20and%20racial%20differences&journal=Cancer%20Causes%20Control&doi=10.1007%2Fs10552-005-3635-6&volume=16&pages=781-787&publication_year=2005&author=Haselkorn%2CT&author=Whittemore%2CAS&author=Lilienfeld%2CDE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="12."><p class="c-article-references__text" id="ref-CR12">Arber N, Neugut AI, Weinstein IB, Holt P (1997) Molecular genetics of small bowel cancer. Cancer Epidemiol Biomark Prev 6:745–748</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK2svktl2isA%3D%3D" aria-label="CAS reference 12">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 12" href="http://scholar.google.com/scholar_lookup?&title=Molecular%20genetics%20of%20small%20bowel%20cancer&journal=Cancer%20Epidemiol%20Biomark%20Prev&volume=6&pages=745-748&publication_year=1997&author=Arber%2CN&author=Neugut%2CAI&author=Weinstein%2CIB&author=Holt%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="13."><p class="c-article-references__text" id="ref-CR13">Sellner F (1990) Investigations on the significance of the adenoma-carcinoma sequence in the small bowel. Cancer 66:702–715</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/1097-0142(19900815)66:4<702::AID-CNCR2820660419>3.0.CO;2-Z" data-track-item_id="10.1002/1097-0142(19900815)66:4<702::AID-CNCR2820660419>3.0.CO;2-Z" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2F1097-0142%2819900815%2966%3A4%3C702%3A%3AAID-CNCR2820660419%3E3.0.CO%3B2-Z" aria-label="Article reference 13" data-doi="10.1002/1097-0142(19900815)66:4<702::AID-CNCR2820660419>3.0.CO;2-Z">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2167140" aria-label="PubMed reference 13">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK3czlt1Gjsg%3D%3D" aria-label="CAS reference 13">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 13" href="http://scholar.google.com/scholar_lookup?&title=Investigations%20on%20the%20significance%20of%20the%20adenoma-carcinoma%20sequence%20in%20the%20small%20bowel&journal=Cancer&doi=10.1002%2F1097-0142%2819900815%2966%3A4%3C702%3A%3AAID-CNCR2820660419%3E3.0.CO%3B2-Z&volume=66&pages=702-715&publication_year=1990&author=Sellner%2CF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="14."><p class="c-article-references__text" id="ref-CR14">Delaunoit T, Neczyporenko F, Limburg PJ, Erlichman C (2005) Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling? Am J Gastroenterol 100:703–710</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1572-0241.2005.40605.x" data-track-item_id="10.1111/j.1572-0241.2005.40605.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1572-0241.2005.40605.x" aria-label="Article reference 14" data-doi="10.1111/j.1572-0241.2005.40605.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15743371" aria-label="PubMed reference 14">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 14" href="http://scholar.google.com/scholar_lookup?&title=Pathogenesis%20and%20risk%20factors%20of%20small%20bowel%20adenocarcinoma%3A%20a%20colorectal%20cancer%20sibling%3F&journal=Am%20J%20Gastroenterol&doi=10.1111%2Fj.1572-0241.2005.40605.x&volume=100&pages=703-710&publication_year=2005&author=Delaunoit%2CT&author=Neczyporenko%2CF&author=Limburg%2CPJ&author=Erlichman%2CC"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="15."><p class="c-article-references__text" id="ref-CR15">Chen CC, Neugut AI, Rotterdam H (1994) Risk factors for adenocarcinomas and malignant carcinoids of the small intestine: preliminary findings. Cancer Epidemiol Biomark Prev 3:205–207</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK2c3ptValug%3D%3D" aria-label="CAS reference 15">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 15" href="http://scholar.google.com/scholar_lookup?&title=Risk%20factors%20for%20adenocarcinomas%20and%20malignant%20carcinoids%20of%20the%20small%20intestine%3A%20preliminary%20findings&journal=Cancer%20Epidemiol%20Biomark%20Prev&volume=3&pages=205-207&publication_year=1994&author=Chen%2CCC&author=Neugut%2CAI&author=Rotterdam%2CH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="16."><p class="c-article-references__text" id="ref-CR16">Pan SY, Morrison H (2011) Epidemiology of cancer of the small intestine. World J Gastrointest Oncol 3:33–42</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.4251/wjgo.v3.i3.33" data-track-item_id="10.4251/wjgo.v3.i3.33" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.4251%2Fwjgo.v3.i3.33" aria-label="Article reference 16" data-doi="10.4251/wjgo.v3.i3.33">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21461167" aria-label="PubMed reference 16">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069308" aria-label="PubMed Central reference 16">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 16" href="http://scholar.google.com/scholar_lookup?&title=Epidemiology%20of%20cancer%20of%20the%20small%20intestine&journal=World%20J%20Gastrointest%20Oncol&doi=10.4251%2Fwjgo.v3.i3.33&volume=3&pages=33-42&publication_year=2011&author=Pan%2CSY&author=Morrison%2CH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="17."><p class="c-article-references__text" id="ref-CR17">Lowenfels AB (1973) Why are small-bowel tumours so rare? Lancet 1:24–26</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0140-6736(73)91228-2" data-track-item_id="10.1016/S0140-6736(73)91228-2" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0140-6736%2873%2991228-2" aria-label="Article reference 17" data-doi="10.1016/S0140-6736(73)91228-2">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=4118541" aria-label="PubMed reference 17">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaE3s%2FmsFWrtw%3D%3D" aria-label="CAS reference 17">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 17" href="http://scholar.google.com/scholar_lookup?&title=Why%20are%20small-bowel%20tumours%20so%20rare%3F&journal=Lancet&doi=10.1016%2FS0140-6736%2873%2991228-2&volume=1&pages=24-26&publication_year=1973&author=Lowenfels%2CAB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="18."><p class="c-article-references__text" id="ref-CR18">Sanders LM, Henderson CE, Hong MY, Barhoumi R, Burghardt RC, Carroll RJ, Turner ND, Chapkin RS, Lupton JR (2004) Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility. Cancer Lett 208:155–161</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.canlet.2003.12.007" data-track-item_id="10.1016/j.canlet.2003.12.007" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.canlet.2003.12.007" aria-label="Article reference 18" data-doi="10.1016/j.canlet.2003.12.007">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15142673" aria-label="PubMed reference 18">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2cXktVOmu78%3D" aria-label="CAS reference 18">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 18" href="http://scholar.google.com/scholar_lookup?&title=Pro-oxidant%20environment%20of%20the%20colon%20compared%20to%20the%20small%20intestine%20may%20contribute%20to%20greater%20cancer%20susceptibility&journal=Cancer%20Lett&doi=10.1016%2Fj.canlet.2003.12.007&volume=208&pages=155-161&publication_year=2004&author=Sanders%2CLM&author=Henderson%2CCE&author=Hong%2CMY&author=Barhoumi%2CR&author=Burghardt%2CRC&author=Carroll%2CRJ&author=Turner%2CND&author=Chapkin%2CRS&author=Lupton%2CJR"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="19."><p class="c-article-references__text" id="ref-CR19">DiSario JA, Burt RW, Vargas H, McWhorter WP (1994) Small bowel cancer: epidemiological and clinical characteristics from a population-based registry. Am J Gastroenterol 89:699–701</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8172140" aria-label="PubMed reference 19">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK2c3is1WjsQ%3D%3D" aria-label="CAS reference 19">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 19" href="http://scholar.google.com/scholar_lookup?&title=Small%20bowel%20cancer%3A%20epidemiological%20and%20clinical%20characteristics%20from%20a%20population-based%20registry&journal=Am%20J%20Gastroenterol&volume=89&pages=699-701&publication_year=1994&author=DiSario%2CJA&author=Burt%2CRW&author=Vargas%2CH&author=McWhorter%2CWP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="20."><p class="c-article-references__text" id="ref-CR20">Ciresi DL, Scholten DJ (1995) The continuing clinical dilemma of primary tumors of the small intestine. Am Surg 61:698–702 discussion 702-693</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7618809" aria-label="PubMed reference 20">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK2MzksVWjuw%3D%3D" aria-label="CAS reference 20">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 20" href="http://scholar.google.com/scholar_lookup?&title=The%20continuing%20clinical%20dilemma%20of%20primary%20tumors%20of%20the%20small%20intestine&journal=Am%20Surg&volume=61&pages=698-702&publication_year=1995&author=Ciresi%2CDL&author=Scholten%2CDJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="21."><p class="c-article-references__text" id="ref-CR21">Schirmacher P, Buchler MW (2008) Ampullary adenocarcinoma—differentiation matters. BMC Cancer 8(251)</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="22."><p class="c-article-references__text" id="ref-CR22">Schwameis K, Schoppmann SF, Stift J, Schwameis M, Stift A (2014) Small bowel adenocarcinoma—terra incognita: a demand for cross-national pooling of data. Oncol Lett 7:1613–1617</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3892/ol.2014.1919" data-track-item_id="10.3892/ol.2014.1919" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3892%2Fol.2014.1919" aria-label="Article reference 22" data-doi="10.3892/ol.2014.1919">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24765188" aria-label="PubMed reference 22">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997673" aria-label="PubMed Central reference 22">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 22" href="http://scholar.google.com/scholar_lookup?&title=Small%20bowel%20adenocarcinoma%E2%80%94terra%20incognita%3A%20a%20demand%20for%20cross-national%20pooling%20of%20data&journal=Oncol%20Lett&doi=10.3892%2Fol.2014.1919&volume=7&pages=1613-1617&publication_year=2014&author=Schwameis%2CK&author=Schoppmann%2CSF&author=Stift%2CJ&author=Schwameis%2CM&author=Stift%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="23."><p class="c-article-references__text" id="ref-CR23">Lowenfels AB (1978) Does bile promote extra-colonic cancer? Lancet 2:239–241</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0140-6736(78)91748-8" data-track-item_id="10.1016/S0140-6736(78)91748-8" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0140-6736%2878%2991748-8" aria-label="Article reference 23" data-doi="10.1016/S0140-6736(78)91748-8">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=79033" aria-label="PubMed reference 23">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaE1c3it1agsA%3D%3D" aria-label="CAS reference 23">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 23" href="http://scholar.google.com/scholar_lookup?&title=Does%20bile%20promote%20extra-colonic%20cancer%3F&journal=Lancet&doi=10.1016%2FS0140-6736%2878%2991748-8&volume=2&pages=239-241&publication_year=1978&author=Lowenfels%2CAB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="24."><p class="c-article-references__text" id="ref-CR24">Ross RK, Hartnett NM, Bernstein L, Henderson BE (1991) Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen? Br J Cancer 63:143–145</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/bjc.1991.29" data-track-item_id="10.1038/bjc.1991.29" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fbjc.1991.29" aria-label="Article reference 24" data-doi="10.1038/bjc.1991.29">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1989654" aria-label="PubMed reference 24">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971637" aria-label="PubMed Central reference 24">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK3M7htlCqtw%3D%3D" aria-label="CAS reference 24">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 24" href="http://scholar.google.com/scholar_lookup?&title=Epidemiology%20of%20adenocarcinomas%20of%20the%20small%20intestine%3A%20is%20bile%20a%20small%20bowel%20carcinogen%3F&journal=Br%20J%20Cancer&doi=10.1038%2Fbjc.1991.29&volume=63&pages=143-145&publication_year=1991&author=Ross%2CRK&author=Hartnett%2CNM&author=Bernstein%2CL&author=Henderson%2CBE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="25."><p class="c-article-references__text" id="ref-CR25">Hatzaras I, Palesty JA, Abir F, Sullivan P, Kozol RA, Dudrick SJ, Longo WE (2007) Small-bowel tumors: epidemiologic and clinical characteristics of 1260 cases from the Connecticut Tumor Registry. Arch Surg 142:229–235</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1001/archsurg.142.3.229" data-track-item_id="10.1001/archsurg.142.3.229" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1001%2Farchsurg.142.3.229" aria-label="Article reference 25" data-doi="10.1001/archsurg.142.3.229">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17372046" aria-label="PubMed reference 25">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 25" href="http://scholar.google.com/scholar_lookup?&title=Small-bowel%20tumors%3A%20epidemiologic%20and%20clinical%20characteristics%20of%201260%20cases%20from%20the%20Connecticut%20Tumor%20Registry&journal=Arch%20Surg&doi=10.1001%2Farchsurg.142.3.229&volume=142&pages=229-235&publication_year=2007&author=Hatzaras%2CI&author=Palesty%2CJA&author=Abir%2CF&author=Sullivan%2CP&author=Kozol%2CRA&author=Dudrick%2CSJ&author=Longo%2CWE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="26."><p class="c-article-references__text" id="ref-CR26">Bauer RL, Palmer ML, Bauer AM, Nava HR, Douglass HO, Jr. (1994) Adenocarcinoma of the small intestine: 21-year review of diagnosis, treatment, and prognosis. Ann Surg Oncol 1;183–188</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="27."><p class="c-article-references__text" id="ref-CR27">Dabaja BS, Suki D, Pro B, Bonnen M, Ajani J (2004) Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer 101:518–526</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/cncr.20404" data-track-item_id="10.1002/cncr.20404" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fcncr.20404" aria-label="Article reference 27" data-doi="10.1002/cncr.20404">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15274064" aria-label="PubMed reference 27">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 27" href="http://scholar.google.com/scholar_lookup?&title=Adenocarcinoma%20of%20the%20small%20bowel%3A%20presentation%2C%20prognostic%20factors%2C%20and%20outcome%20of%20217%20patients&journal=Cancer&doi=10.1002%2Fcncr.20404&volume=101&pages=518-526&publication_year=2004&author=Dabaja%2CBS&author=Suki%2CD&author=Pro%2CB&author=Bonnen%2CM&author=Ajani%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="28."><p class="c-article-references__text" id="ref-CR28">Talamonti MS, Goetz LH, Rao S, Joehl RJ (2002) Primary cancers of the small bowel: analysis of prognostic factors and results of surgical management. Arch Surg 137:564–570 discussion 570-561</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1001/archsurg.137.5.564" data-track-item_id="10.1001/archsurg.137.5.564" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1001%2Farchsurg.137.5.564" aria-label="Article reference 28" data-doi="10.1001/archsurg.137.5.564">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11982470" aria-label="PubMed reference 28">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 28" href="http://scholar.google.com/scholar_lookup?&title=Primary%20cancers%20of%20the%20small%20bowel%3A%20analysis%20of%20prognostic%20factors%20and%20results%20of%20surgical%20management&journal=Arch%20Surg&doi=10.1001%2Farchsurg.137.5.564&volume=137&pages=564-570&publication_year=2002&author=Talamonti%2CMS&author=Goetz%2CLH&author=Rao%2CS&author=Joehl%2CRJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="29."><p class="c-article-references__text" id="ref-CR29">Howe JR, Karnell LH, Menck HR, Scott-Conner C (1999) The American College of Surgeons commission on cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the national cancer data base, 1985-1995. Cancer 86:2693–2706</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/(SICI)1097-0142(19991215)86:12<2693::AID-CNCR14>3.0.CO;2-U" data-track-item_id="10.1002/(SICI)1097-0142(19991215)86:12<2693::AID-CNCR14>3.0.CO;2-U" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2F%28SICI%291097-0142%2819991215%2986%3A12%3C2693%3A%3AAID-CNCR14%3E3.0.CO%3B2-U" aria-label="Article reference 29" data-doi="10.1002/(SICI)1097-0142(19991215)86:12<2693::AID-CNCR14>3.0.CO;2-U">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10594865" aria-label="PubMed reference 29">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3c%2Fmt1Gnuw%3D%3D" aria-label="CAS reference 29">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 29" href="http://scholar.google.com/scholar_lookup?&title=The%20American%20College%20of%20Surgeons%20commission%20on%20cancer%20and%20the%20American%20Cancer%20Society.%20Adenocarcinoma%20of%20the%20small%20bowel%3A%20review%20of%20the%20national%20cancer%20data%20base%2C%201985-1995&journal=Cancer&doi=10.1002%2F%28SICI%291097-0142%2819991215%2986%3A12%3C2693%3A%3AAID-CNCR14%3E3.0.CO%3B2-U&volume=86&pages=2693-2706&publication_year=1999&author=Howe%2CJR&author=Karnell%2CLH&author=Menck%2CHR&author=Scott-Conner%2CC"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="30."><p class="c-article-references__text" id="ref-CR30">Overman MJ, Hu CY, Wolff RA, Chang GJ (2010) Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database. Cancer 116:5374–5382</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/cncr.25324" data-track-item_id="10.1002/cncr.25324" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fcncr.25324" aria-label="Article reference 30" data-doi="10.1002/cncr.25324">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20715162" aria-label="PubMed reference 30">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 30" href="http://scholar.google.com/scholar_lookup?&title=Prognostic%20value%20of%20lymph%20node%20evaluation%20in%20small%20bowel%20adenocarcinoma%3A%20analysis%20of%20the%20surveillance%2C%20epidemiology%2C%20and%20end%20results%20database&journal=Cancer&doi=10.1002%2Fcncr.25324&volume=116&pages=5374-5382&publication_year=2010&author=Overman%2CMJ&author=Hu%2CCY&author=Wolff%2CRA&author=Chang%2CGJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="31."><p class="c-article-references__text" id="ref-CR31">Balmforth DC, Phillips RK, Clark SK (2012) Advanced duodenal disease in familial adenomatous polyposis: how frequently should patients be followed up after successful therapy? Familial Cancer 11:553–557</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s10689-012-9546-2" data-track-item_id="10.1007/s10689-012-9546-2" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s10689-012-9546-2" aria-label="Article reference 31" data-doi="10.1007/s10689-012-9546-2">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22760847" aria-label="PubMed reference 31">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 31" href="http://scholar.google.com/scholar_lookup?&title=Advanced%20duodenal%20disease%20in%20familial%20adenomatous%20polyposis%3A%20how%20frequently%20should%20patients%20be%20followed%20up%20after%20successful%20therapy%3F&journal=Familial%20Cancer&doi=10.1007%2Fs10689-012-9546-2&volume=11&pages=553-557&publication_year=2012&author=Balmforth%2CDC&author=Phillips%2CRK&author=Clark%2CSK"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="32."><p class="c-article-references__text" id="ref-CR32">Spigelman AD, Williams CB, Talbot IC, Domizio P, Phillips RK (1989) Upper gastrointestinal cancer in patients with familial adenomatous polyposis. Lancet 2:783–785</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0140-6736(89)90840-4" data-track-item_id="10.1016/S0140-6736(89)90840-4" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0140-6736%2889%2990840-4" aria-label="Article reference 32" data-doi="10.1016/S0140-6736(89)90840-4">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2571019" aria-label="PubMed reference 32">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaL1MzotlOrsg%3D%3D" aria-label="CAS reference 32">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 32" href="http://scholar.google.com/scholar_lookup?&title=Upper%20gastrointestinal%20cancer%20in%20patients%20with%20familial%20adenomatous%20polyposis&journal=Lancet&doi=10.1016%2FS0140-6736%2889%2990840-4&volume=2&pages=783-785&publication_year=1989&author=Spigelman%2CAD&author=Williams%2CCB&author=Talbot%2CIC&author=Domizio%2CP&author=Phillips%2CRK"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="33."><p class="c-article-references__text" id="ref-CR33">Xie J (2008) Cancer in inflammatory bowel disease. World J Gastroenterol 14:378–389</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3748/wjg.14.378" data-track-item_id="10.3748/wjg.14.378" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3748%2Fwjg.14.378" aria-label="Article reference 33" data-doi="10.3748/wjg.14.378">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18200660" aria-label="PubMed reference 33">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679126" aria-label="PubMed Central reference 33">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1cXjvFKkt7g%3D" aria-label="CAS reference 33">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 33" href="http://scholar.google.com/scholar_lookup?&title=Cancer%20in%20inflammatory%20bowel%20disease&journal=World%20J%20Gastroenterol&doi=10.3748%2Fwjg.14.378&volume=14&pages=378-389&publication_year=2008&author=Xie%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="34."><p class="c-article-references__text" id="ref-CR34">Egan L, D’Inca R, Jess T, Pellino G, Carbonnel F, Bokemeyer B, Harbord M, Nunes P, van der Woude J, Selvaggi F, Triantafillidis J (2014) Non-colorectal intestinal tract carcinomas in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (ii). J Crohn’s Colitis 8:19–30</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.crohns.2013.04.009" data-track-item_id="10.1016/j.crohns.2013.04.009" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.crohns.2013.04.009" aria-label="Article reference 34" data-doi="10.1016/j.crohns.2013.04.009">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 34" href="http://scholar.google.com/scholar_lookup?&title=Non-colorectal%20intestinal%20tract%20carcinomas%20in%20inflammatory%20bowel%20disease%3A%20results%20of%20the%203rd%20ECCO%20pathogenesis%20scientific%20workshop%20%28ii%29&journal=J%20Crohn%E2%80%99s%20Colitis&doi=10.1016%2Fj.crohns.2013.04.009&volume=8&pages=19-30&publication_year=2014&author=Egan%2CL&author=D%E2%80%99Inca%2CR&author=Jess%2CT&author=Pellino%2CG&author=Carbonnel%2CF&author=Bokemeyer%2CB&author=Harbord%2CM&author=Nunes%2CP&author=van%20der%20Woude%2CJ&author=Selvaggi%2CF&author=Triantafillidis%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="35."><p class="c-article-references__text" id="ref-CR35">Svrcek M, Piton G, Cosnes J, Beaugerie L, Vermeire S, Geboes K, Lemoine A, Cervera P, el-Murr N, Dumont S, Scriva A, Lascols O, Ardizzone S, Fociani P, Savoye G, le Pessot F, Novacek G, Wrba F, Colombel JF, Leteurtre E, Bouhnik Y, Cazals-Hatem D, Cadiot G, Diebold MD, Rahier JF, Delos M, Fléjou JF, Carbonnel F (2014) Small bowel adenocarcinomas complicating Crohn’s disease are associated with dysplasia: a pathological and molecular study. Inflamm Bowel Dis 20:1584–1592</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/MIB.0000000000000112" data-track-item_id="10.1097/MIB.0000000000000112" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FMIB.0000000000000112" aria-label="Article reference 35" data-doi="10.1097/MIB.0000000000000112">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25029614" aria-label="PubMed reference 35">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 35" href="http://scholar.google.com/scholar_lookup?&title=Small%20bowel%20adenocarcinomas%20complicating%20Crohn%E2%80%99s%20disease%20are%20associated%20with%20dysplasia%3A%20a%20pathological%20and%20molecular%20study&journal=Inflamm%20Bowel%20Dis&doi=10.1097%2FMIB.0000000000000112&volume=20&pages=1584-1592&publication_year=2014&author=Svrcek%2CM&author=Piton%2CG&author=Cosnes%2CJ&author=Beaugerie%2CL&author=Vermeire%2CS&author=Geboes%2CK&author=Lemoine%2CA&author=Cervera%2CP&author=el-Murr%2CN&author=Dumont%2CS&author=Scriva%2CA&author=Lascols%2CO&author=Ardizzone%2CS&author=Fociani%2CP&author=Savoye%2CG&author=le%20Pessot%2CF&author=Novacek%2CG&author=Wrba%2CF&author=Colombel%2CJF&author=Leteurtre%2CE&author=Bouhnik%2CY&author=Cazals-Hatem%2CD&author=Cadiot%2CG&author=Diebold%2CMD&author=Rahier%2CJF&author=Delos%2CM&author=Fl%C3%A9jou%2CJF&author=Carbonnel%2CF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="36."><p class="c-article-references__text" id="ref-CR36">Piton G, Cosnes J, Monnet E, Beaugerie L, Seksik P, Savoye G, Cadiot G, Flourie B, Capelle P, Marteau P, Lemann M, Colombel JF, Khouri E, Bonaz B, Carbonnel F (2008) Risk factors associated with small bowel adenocarcinoma in Crohn’s disease: a case-control study. Am J Gastroenterol 103:1730–1736</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1572-0241.2008.01847.x" data-track-item_id="10.1111/j.1572-0241.2008.01847.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1572-0241.2008.01847.x" aria-label="Article reference 36" data-doi="10.1111/j.1572-0241.2008.01847.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18564124" aria-label="PubMed reference 36">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 36" href="http://scholar.google.com/scholar_lookup?&title=Risk%20factors%20associated%20with%20small%20bowel%20adenocarcinoma%20in%20Crohn%E2%80%99s%20disease%3A%20a%20case-control%20study&journal=Am%20J%20Gastroenterol&doi=10.1111%2Fj.1572-0241.2008.01847.x&volume=103&pages=1730-1736&publication_year=2008&author=Piton%2CG&author=Cosnes%2CJ&author=Monnet%2CE&author=Beaugerie%2CL&author=Seksik%2CP&author=Savoye%2CG&author=Cadiot%2CG&author=Flourie%2CB&author=Capelle%2CP&author=Marteau%2CP&author=Lemann%2CM&author=Colombel%2CJF&author=Khouri%2CE&author=Bonaz%2CB&author=Carbonnel%2CF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="37."><p class="c-article-references__text" id="ref-CR37">von Roon AC, Reese G, Teare J, Constantinides V, Darzi AW, Tekkis PP (2007) The risk of cancer in patients with Crohn’s disease. Dis Colon Rectum 50:839–855</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s10350-006-0848-z" data-track-item_id="10.1007/s10350-006-0848-z" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s10350-006-0848-z" aria-label="Article reference 37" data-doi="10.1007/s10350-006-0848-z">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 37" href="http://scholar.google.com/scholar_lookup?&title=The%20risk%20of%20cancer%20in%20patients%20with%20Crohn%E2%80%99s%20disease&journal=Dis%20Colon%20Rectum&doi=10.1007%2Fs10350-006-0848-z&volume=50&pages=839-855&publication_year=2007&author=Roon%2CAC&author=Reese%2CG&author=Teare%2CJ&author=Constantinides%2CV&author=Darzi%2CAW&author=Tekkis%2CPP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="38."><p class="c-article-references__text" id="ref-CR38">Canavan C, Abrams KR, Mayberry J (2006) Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther 23:1097–1104</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1365-2036.2006.02854.x" data-track-item_id="10.1111/j.1365-2036.2006.02854.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1365-2036.2006.02854.x" aria-label="Article reference 38" data-doi="10.1111/j.1365-2036.2006.02854.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16611269" aria-label="PubMed reference 38">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD283gsVKnsw%3D%3D" aria-label="CAS reference 38">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 38" href="http://scholar.google.com/scholar_lookup?&title=Meta-analysis%3A%20colorectal%20and%20small%20bowel%20cancer%20risk%20in%20patients%20with%20Crohn%E2%80%99s%20disease&journal=Aliment%20Pharmacol%20Ther&doi=10.1111%2Fj.1365-2036.2006.02854.x&volume=23&pages=1097-1104&publication_year=2006&author=Canavan%2CC&author=Abrams%2CKR&author=Mayberry%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="39."><p class="c-article-references__text" id="ref-CR39">Jess T, Gamborg M, Matzen P, Munkholm P, Sorensen TI (2005) Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol 100:2724–2729</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1572-0241.2005.00287.x" data-track-item_id="10.1111/j.1572-0241.2005.00287.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1572-0241.2005.00287.x" aria-label="Article reference 39" data-doi="10.1111/j.1572-0241.2005.00287.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16393226" aria-label="PubMed reference 39">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 39" href="http://scholar.google.com/scholar_lookup?&title=Increased%20risk%20of%20intestinal%20cancer%20in%20Crohn%E2%80%99s%20disease%3A%20a%20meta-analysis%20of%20population-based%20cohort%20studies&journal=Am%20J%20Gastroenterol&doi=10.1111%2Fj.1572-0241.2005.00287.x&volume=100&pages=2724-2729&publication_year=2005&author=Jess%2CT&author=Gamborg%2CM&author=Matzen%2CP&author=Munkholm%2CP&author=Sorensen%2CTI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="40."><p class="c-article-references__text" id="ref-CR40">Askling J, Linet M, Gridley G, Halstensen TS, Ekstrom K, Ekbom A (2002) Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 123:1428–1435</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1053/gast.2002.36585" data-track-item_id="10.1053/gast.2002.36585" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1053%2Fgast.2002.36585" aria-label="Article reference 40" data-doi="10.1053/gast.2002.36585">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12404215" aria-label="PubMed reference 40">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 40" href="http://scholar.google.com/scholar_lookup?&title=Cancer%20incidence%20in%20a%20population-based%20cohort%20of%20individuals%20hospitalized%20with%20celiac%20disease%20or%20dermatitis%20herpetiformis&journal=Gastroenterology&doi=10.1053%2Fgast.2002.36585&volume=123&pages=1428-1435&publication_year=2002&author=Askling%2CJ&author=Linet%2CM&author=Gridley%2CG&author=Halstensen%2CTS&author=Ekstrom%2CK&author=Ekbom%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="41."><p class="c-article-references__text" id="ref-CR41">Howdle PD, Jalal PK, Holmes GK, Houlston RS (2003) Primary small-bowel malignancy in the UK and its association with coeliac disease. QJM 96:345–353</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/qjmed/hcg058" data-track-item_id="10.1093/qjmed/hcg058" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Fqjmed%2Fhcg058" aria-label="Article reference 41" data-doi="10.1093/qjmed/hcg058">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12702783" aria-label="PubMed reference 41">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3s7otl2msw%3D%3D" aria-label="CAS reference 41">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 41" href="http://scholar.google.com/scholar_lookup?&title=Primary%20small-bowel%20malignancy%20in%20the%20UK%20and%20its%20association%20with%20coeliac%20disease&journal=QJM&doi=10.1093%2Fqjmed%2Fhcg058&volume=96&pages=345-353&publication_year=2003&author=Howdle%2CPD&author=Jalal%2CPK&author=Holmes%2CGK&author=Houlston%2CRS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="42."><p class="c-article-references__text" id="ref-CR42">Nicholl MB, Ahuja V, Conway WC, Vu VD, Sim MS, Singh G (2010) Small bowel adenocarcinoma: understaged and undertreated? Ann Surg Oncol 17:2728–2732</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1245/s10434-010-1109-x" data-track-item_id="10.1245/s10434-010-1109-x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1245%2Fs10434-010-1109-x" aria-label="Article reference 42" data-doi="10.1245/s10434-010-1109-x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20458546" aria-label="PubMed reference 42">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 42" href="http://scholar.google.com/scholar_lookup?&title=Small%20bowel%20adenocarcinoma%3A%20understaged%20and%20undertreated%3F&journal=Ann%20Surg%20Oncol&doi=10.1245%2Fs10434-010-1109-x&volume=17&pages=2728-2732&publication_year=2010&author=Nicholl%2CMB&author=Ahuja%2CV&author=Conway%2CWC&author=Vu%2CVD&author=Sim%2CMS&author=Singh%2CG"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="43."><p class="c-article-references__text" id="ref-CR43">Koo DH, Yun SC, Hong YS, Ryu MH, Lee JL, Chang HM, Ryoo BY, Kang YK, Kim TW (2011) Systemic chemotherapy for treatment of advanced small bowel adenocarcinoma with prognostic factor analysis: retrospective study. BMC Cancer 11:205</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="44."><p class="c-article-references__text" id="ref-CR44">Zaanan A, Costes L, Gauthier M, Malka D, Locher C, Mitry E, Tougeron D, Lecomte T, Gornet JM, Sobhani I, Moulin V, Afchain P, Taieb J, Bonnetain F, Aparicio T (2010) Chemotherapy of advanced small-bowel adenocarcinoma: a multicenter AGEO study. Ann Oncol 21:1786–1793</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/annonc/mdq038" data-track-item_id="10.1093/annonc/mdq038" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Fannonc%2Fmdq038" aria-label="Article reference 44" data-doi="10.1093/annonc/mdq038">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20223786" aria-label="PubMed reference 44">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BC3cjmtlCnsw%3D%3D" aria-label="CAS reference 44">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 44" href="http://scholar.google.com/scholar_lookup?&title=Chemotherapy%20of%20advanced%20small-bowel%20adenocarcinoma%3A%20a%20multicenter%20AGEO%20study&journal=Ann%20Oncol&doi=10.1093%2Fannonc%2Fmdq038&volume=21&pages=1786-1793&publication_year=2010&author=Zaanan%2CA&author=Costes%2CL&author=Gauthier%2CM&author=Malka%2CD&author=Locher%2CC&author=Mitry%2CE&author=Tougeron%2CD&author=Lecomte%2CT&author=Gornet%2CJM&author=Sobhani%2CI&author=Moulin%2CV&author=Afchain%2CP&author=Taieb%2CJ&author=Bonnetain%2CF&author=Aparicio%2CT"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="45."><p class="c-article-references__text" id="ref-CR45">Khan K, Peckitt C, Sclafani F, Watkins D, Rao S, Starling N, Jain V, Trivedi S, Stanway S, Cunningham D, Chau I (2015) Prognostic factors and treatment outcomes in patients with small bowel adenocarcinoma (SBA): the Royal Marsden Hospital (RMH) experience. BMC Cancer 15(15):15</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1186/s12885-015-1014-6" data-track-item_id="10.1186/s12885-015-1014-6" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1186/s12885-015-1014-6" aria-label="Article reference 45" data-doi="10.1186/s12885-015-1014-6">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25603878" aria-label="PubMed reference 45">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305243" aria-label="PubMed Central reference 45">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 45" href="http://scholar.google.com/scholar_lookup?&title=Prognostic%20factors%20and%20treatment%20outcomes%20in%20patients%20with%20small%20bowel%20adenocarcinoma%20%28SBA%29%3A%20the%20Royal%20Marsden%20Hospital%20%28RMH%29%20experience&journal=BMC%20Cancer&doi=10.1186%2Fs12885-015-1014-6&volume=15&issue=15&publication_year=2015&author=Khan%2CK&author=Peckitt%2CC&author=Sclafani%2CF&author=Watkins%2CD&author=Rao%2CS&author=Starling%2CN&author=Jain%2CV&author=Trivedi%2CS&author=Stanway%2CS&author=Cunningham%2CD&author=Chau%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="46."><p class="c-article-references__text" id="ref-CR46">Overman MJ, Kopetz S, Lin E, Abbruzzese JL, Wolff RA (2010) Is there a role for adjuvant therapy in resected adenocarcinoma of the small intestine. Acta Oncol 49:474–479</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3109/02841860903490051" data-track-item_id="10.3109/02841860903490051" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3109%2F02841860903490051" aria-label="Article reference 46" data-doi="10.3109/02841860903490051">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20397775" aria-label="PubMed reference 46">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 46" href="http://scholar.google.com/scholar_lookup?&title=Is%20there%20a%20role%20for%20adjuvant%20therapy%20in%20resected%20adenocarcinoma%20of%20the%20small%20intestine&journal=Acta%20Oncol&doi=10.3109%2F02841860903490051&volume=49&pages=474-479&publication_year=2010&author=Overman%2CMJ&author=Kopetz%2CS&author=Lin%2CE&author=Abbruzzese%2CJL&author=Wolff%2CRA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="47."><p class="c-article-references__text" id="ref-CR47">Mizushima T, Tamagawa H, Mishima H et al (2013) The effects of chemotherapy on primary small bowel cancer: a retrospective multicenter observational study in Japan. Mol Clin Oncol 1:820–824</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3892/mco.2013.150" data-track-item_id="10.3892/mco.2013.150" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3892%2Fmco.2013.150" aria-label="Article reference 47" data-doi="10.3892/mco.2013.150">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24649253" aria-label="PubMed reference 47">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916178" aria-label="PubMed Central reference 47">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 47" href="http://scholar.google.com/scholar_lookup?&title=The%20effects%20of%20chemotherapy%20on%20primary%20small%20bowel%20cancer%3A%20a%20retrospective%20multicenter%20observational%20study%20in%20Japan&journal=Mol%20Clin%20Oncol&doi=10.3892%2Fmco.2013.150&volume=1&pages=820-824&publication_year=2013&author=Mizushima%2CT&author=Tamagawa%2CH&author=Mishima%2CH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="48."><p class="c-article-references__text" id="ref-CR48">Guo XC, Mao ZY, Su D, Wang LJ, Zhang TT, Bai L (2014) Retrospective analysis of 119 small bowel adenocarcinoma in Chinese patients. Cancer Investig 32:178–183</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3109/07357907.2014.896013" data-track-item_id="10.3109/07357907.2014.896013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3109%2F07357907.2014.896013" aria-label="Article reference 48" data-doi="10.3109/07357907.2014.896013">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC2cXnsVSksbw%3D" aria-label="CAS reference 48">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 48" href="http://scholar.google.com/scholar_lookup?&title=Retrospective%20analysis%20of%20119%20small%20bowel%20adenocarcinoma%20in%20Chinese%20patients&journal=Cancer%20Investig&doi=10.3109%2F07357907.2014.896013&volume=32&pages=178-183&publication_year=2014&author=Guo%2CXC&author=Mao%2CZY&author=Su%2CD&author=Wang%2CLJ&author=Zhang%2CTT&author=Bai%2CL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="49."><p class="c-article-references__text" id="ref-CR49">Koo DH, Yun SC, Hong YS, Ryu MH, Lee JL, Chang HM, Kang YK, Kim SC, Han DJ, Lee YJ, Kim TW (2011) Adjuvant chemotherapy for small bowel adenocarcinoma after curative surgery. Oncology (Williston Park) 80:208–213</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1159/000328506" data-track-item_id="10.1159/000328506" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1159%2F000328506" aria-label="Article reference 49" data-doi="10.1159/000328506">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC3MXpt1Cjt7g%3D" aria-label="CAS reference 49">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 49" href="http://scholar.google.com/scholar_lookup?&title=Adjuvant%20chemotherapy%20for%20small%20bowel%20adenocarcinoma%20after%20curative%20surgery&journal=Oncology%20%28Williston%20Park%29&doi=10.1159%2F000328506&volume=80&pages=208-213&publication_year=2011&author=Koo%2CDH&author=Yun%2CSC&author=Hong%2CYS&author=Ryu%2CMH&author=Lee%2CJL&author=Chang%2CHM&author=Kang%2CYK&author=Kim%2CSC&author=Han%2CDJ&author=Lee%2CYJ&author=Kim%2CTW"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="50."><p class="c-article-references__text" id="ref-CR50">Halfdanarson TR, McWilliams RR, Donohue JH, Quevedo JF (2010) A single-institution experience with 491 cases of small bowel adenocarcinoma. Am J Surg 199:797–803</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.amjsurg.2009.05.037" data-track-item_id="10.1016/j.amjsurg.2009.05.037" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.amjsurg.2009.05.037" aria-label="Article reference 50" data-doi="10.1016/j.amjsurg.2009.05.037">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20609724" aria-label="PubMed reference 50">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 50" href="http://scholar.google.com/scholar_lookup?&title=A%20single-institution%20experience%20with%20491%20cases%20of%20small%20bowel%20adenocarcinoma&journal=Am%20J%20Surg&doi=10.1016%2Fj.amjsurg.2009.05.037&volume=199&pages=797-803&publication_year=2010&author=Halfdanarson%2CTR&author=McWilliams%2CRR&author=Donohue%2CJH&author=Quevedo%2CJF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="51."><p class="c-article-references__text" id="ref-CR51">Overman MJ (2013) Rare but real: management of small bowel adenocarcinoma. Am Soc Clin Oncol Educ Book 189–193</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="52."><p class="c-article-references__text" id="ref-CR52">Bogaerts J, Sydes MR, Keat N et al (2014) Clinical trial designs for rare diseases: studies developed and discussed by the international rare cancers initiative. Eur J Cancer 51:271–281</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.ejca.2014.10.027" data-track-item_id="10.1016/j.ejca.2014.10.027" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.ejca.2014.10.027" aria-label="Article reference 52" data-doi="10.1016/j.ejca.2014.10.027">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25542058" aria-label="PubMed reference 52">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 52" href="http://scholar.google.com/scholar_lookup?&title=Clinical%20trial%20designs%20for%20rare%20diseases%3A%20studies%20developed%20and%20discussed%20by%20the%20international%20rare%20cancers%20initiative&journal=Eur%20J%20Cancer&doi=10.1016%2Fj.ejca.2014.10.027&volume=51&pages=271-281&publication_year=2014&author=Bogaerts%2CJ&author=Sydes%2CMR&author=Keat%2CN"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="53."><p class="c-article-references__text" id="ref-CR53">Valsangkar NP, Ingkakul T, Correa-Gallego C, Mino-Kenudson M, Masia R, Lillemoe KD, Castillo CFD, Warshaw AL, Liss AS, Thayer SP (2015) Survival in ampullary cancer: potential role of different KRAS mutations. Surgery 157:260–268</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.surg.2014.08.092" data-track-item_id="10.1016/j.surg.2014.08.092" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.surg.2014.08.092" aria-label="Article reference 53" data-doi="10.1016/j.surg.2014.08.092">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25616942" aria-label="PubMed reference 53">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451831" aria-label="PubMed Central reference 53">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 53" href="http://scholar.google.com/scholar_lookup?&title=Survival%20in%20ampullary%20cancer%3A%20potential%20role%20of%20different%20KRAS%20mutations&journal=Surgery&doi=10.1016%2Fj.surg.2014.08.092&volume=157&pages=260-268&publication_year=2015&author=Valsangkar%2CNP&author=Ingkakul%2CT&author=Correa-Gallego%2CC&author=Mino-Kenudson%2CM&author=Masia%2CR&author=Lillemoe%2CKD&author=Castillo%2CCFD&author=Warshaw%2CAL&author=Liss%2CAS&author=Thayer%2CSP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="54."><p class="c-article-references__text" id="ref-CR54">Kohler I, Jacob D, Budzies J, Lehmann A, Weichert W, Schulz S, Neuhaus P, Röcken C (2011) Phenotypic and genotypic characterization of carcinomas of the papilla of vater has prognostic and putative therapeutic implications. Am J Clin Pathol 135:202–211</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1309/AJCPCTCUQSYI89YT" data-track-item_id="10.1309/AJCPCTCUQSYI89YT" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1309%2FAJCPCTCUQSYI89YT" aria-label="Article reference 54" data-doi="10.1309/AJCPCTCUQSYI89YT">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21228360" aria-label="PubMed reference 54">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 54" href="http://scholar.google.com/scholar_lookup?&title=Phenotypic%20and%20genotypic%20characterization%20of%20carcinomas%20of%20the%20papilla%20of%20vater%20has%20prognostic%20and%20putative%20therapeutic%20implications&journal=Am%20J%20Clin%20Pathol&doi=10.1309%2FAJCPCTCUQSYI89YT&volume=135&pages=202-211&publication_year=2011&author=Kohler%2CI&author=Jacob%2CD&author=Budzies%2CJ&author=Lehmann%2CA&author=Weichert%2CW&author=Schulz%2CS&author=Neuhaus%2CP&author=R%C3%B6cken%2CC"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="55."><p class="c-article-references__text" id="ref-CR55">Schultz NA, Roslind A, Christensen IJ, Horn T, Høgdall E, Pedersen LN, Kruhøffer M, Burcharth F, Wøjdemann M, Johansen JS (2012) Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas. Pancreas 41:759–766</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22699145" aria-label="PubMed reference 55">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC38XhtFGjt7fK" aria-label="CAS reference 55">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 55" href="http://scholar.google.com/scholar_lookup?&title=Frequencies%20and%20prognostic%20role%20of%20KRAS%20and%20BRAF%20mutations%20in%20patients%20with%20localized%20pancreatic%20and%20ampullary%20adenocarcinomas&journal=Pancreas&volume=41&pages=759-766&publication_year=2012&author=Schultz%2CNA&author=Roslind%2CA&author=Christensen%2CIJ&author=Horn%2CT&author=H%C3%B8gdall%2CE&author=Pedersen%2CLN&author=Kruh%C3%B8ffer%2CM&author=Burcharth%2CF&author=W%C3%B8jdemann%2CM&author=Johansen%2CJS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="56."><p class="c-article-references__text" id="ref-CR56">Blaker H, von Herbay A, Penzel R, Gross S, Otto HF (2002) Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene. Oncogene 21(1):158–164</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/sj.onc.1205041" data-track-item_id="10.1038/sj.onc.1205041" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fsj.onc.1205041" aria-label="Article reference 56" data-doi="10.1038/sj.onc.1205041">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11791187" aria-label="PubMed reference 56">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD38Xos1yhtQ%3D%3D" aria-label="CAS reference 56">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 56" href="http://scholar.google.com/scholar_lookup?&title=Genetics%20of%20adenocarcinomas%20of%20the%20small%20intestine%3A%20frequent%20deletions%20at%20chromosome%2018q%20and%20mutations%20of%20the%20SMAD4%20gene&journal=Oncogene&doi=10.1038%2Fsj.onc.1205041&volume=21&issue=1&pages=158-164&publication_year=2002&author=Blaker%2CH&author=Herbay%2CA&author=Penzel%2CR&author=Gross%2CS&author=Otto%2CHF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="57."><p class="c-article-references__text" id="ref-CR57">Wheeler JM, Warren BF, Mortensen NJ, Kim HC, Biddolph SC, Elia G, Beck NE, Williams GT, Shepherd NA, Bateman AC, Bodmer WF (2002) An insight into the genetic pathway of adenocarcinoma of the small intestine. Gut 50(2):218–223</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1136/gut.50.2.218" data-track-item_id="10.1136/gut.50.2.218" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1136%2Fgut.50.2.218" aria-label="Article reference 57" data-doi="10.1136/gut.50.2.218">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11788563" aria-label="PubMed reference 57">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773117" aria-label="PubMed Central reference 57">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD38%2Fos1Sqsw%3D%3D" aria-label="CAS reference 57">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 57" href="http://scholar.google.com/scholar_lookup?&title=An%20insight%20into%20the%20genetic%20pathway%20of%20adenocarcinoma%20of%20the%20small%20intestine&journal=Gut&doi=10.1136%2Fgut.50.2.218&volume=50&issue=2&pages=218-223&publication_year=2002&author=Wheeler%2CJM&author=Warren%2CBF&author=Mortensen%2CNJ&author=Kim%2CHC&author=Biddolph%2CSC&author=Elia%2CG&author=Beck%2CNE&author=Williams%2CGT&author=Shepherd%2CNA&author=Bateman%2CAC&author=Bodmer%2CWF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="58."><p class="c-article-references__text" id="ref-CR58">Schrock AB, Devoe CE, McWilliams R, Sun J, Aparicio T, Stephens PJ, Ross JS, Wilson R, Miller VA, Ali SM, Overman MJ (2017) Genomic profiling of small-bowel adenocarcinoma. JAMA Oncol 3:1546–1553</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1001/jamaoncol.2017.1051" data-track-item_id="10.1001/jamaoncol.2017.1051" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1001%2Fjamaoncol.2017.1051" aria-label="Article reference 58" data-doi="10.1001/jamaoncol.2017.1051">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=28617917" aria-label="PubMed reference 58">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 58" href="http://scholar.google.com/scholar_lookup?&title=Genomic%20profiling%20of%20small-bowel%20adenocarcinoma&journal=JAMA%20Oncol&doi=10.1001%2Fjamaoncol.2017.1051&volume=3&pages=1546-1553&publication_year=2017&author=Schrock%2CAB&author=Devoe%2CCE&author=McWilliams%2CR&author=Sun%2CJ&author=Aparicio%2CT&author=Stephens%2CPJ&author=Ross%2CJS&author=Wilson%2CR&author=Miller%2CVA&author=Ali%2CSM&author=Overman%2CMJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="59."><p class="c-article-references__text" id="ref-CR59">Laforest A, Aparicio T, Zaanan A, Silva FP, Didelot A, Desbeaux A, le Corre D, Benhaim L, Pallier K, Aust D, Pistorius S, Blons H, Svrcek M, Laurent-Puig P (2014) ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma. Eur J Cancer 50:1740–1746</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.ejca.2014.04.007" data-track-item_id="10.1016/j.ejca.2014.04.007" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.ejca.2014.04.007" aria-label="Article reference 59" data-doi="10.1016/j.ejca.2014.04.007">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24797764" aria-label="PubMed reference 59">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC2cXns1Wntr8%3D" aria-label="CAS reference 59">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 59" href="http://scholar.google.com/scholar_lookup?&title=ERBB2%20gene%20as%20a%20potential%20therapeutic%20target%20in%20small%20bowel%20adenocarcinoma&journal=Eur%20J%20Cancer&doi=10.1016%2Fj.ejca.2014.04.007&volume=50&pages=1740-1746&publication_year=2014&author=Laforest%2CA&author=Aparicio%2CT&author=Zaanan%2CA&author=Silva%2CFP&author=Didelot%2CA&author=Desbeaux%2CA&author=le%20Corre%2CD&author=Benhaim%2CL&author=Pallier%2CK&author=Aust%2CD&author=Pistorius%2CS&author=Blons%2CH&author=Svrcek%2CM&author=Laurent-Puig%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="60."><p class="c-article-references__text" id="ref-CR60">Le DT, Uram JN, Wang H et al (2015) PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372:2509–2520</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1056/NEJMoa1500596" data-track-item_id="10.1056/NEJMoa1500596" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1056%2FNEJMoa1500596" aria-label="Article reference 60" data-doi="10.1056/NEJMoa1500596">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26028255" aria-label="PubMed reference 60">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481136" aria-label="PubMed Central reference 60">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC2MXhtFyrsbrI" aria-label="CAS reference 60">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 60" href="http://scholar.google.com/scholar_lookup?&title=PD-1%20blockade%20in%20tumors%20with%20mismatch-repair%20deficiency&journal=N%20Engl%20J%20Med&doi=10.1056%2FNEJMoa1500596&volume=372&pages=2509-2520&publication_year=2015&author=Le%2CDT&author=Uram%2CJN&author=Wang%2CH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="61."><p class="c-article-references__text" id="ref-CR61">Planck M, Ericson K, Piotrowska Z, Halvarsson B, Rambech E, Nilbert M (2003) Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine. Cancer 97:1551–1557</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/cncr.11197" data-track-item_id="10.1002/cncr.11197" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fcncr.11197" aria-label="Article reference 61" data-doi="10.1002/cncr.11197">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12627520" aria-label="PubMed reference 61">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD3sXisVKgsbY%3D" aria-label="CAS reference 61">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 61" href="http://scholar.google.com/scholar_lookup?&title=Microsatellite%20instability%20and%20expression%20of%20MLH1%20and%20MSH2%20in%20carcinomas%20of%20the%20small%20intestine&journal=Cancer&doi=10.1002%2Fcncr.11197&volume=97&pages=1551-1557&publication_year=2003&author=Planck%2CM&author=Ericson%2CK&author=Piotrowska%2CZ&author=Halvarsson%2CB&author=Rambech%2CE&author=Nilbert%2CM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="62."><p class="c-article-references__text" id="ref-CR62">Brueckl WM, Heinze E, Milsmann C, Wein A, Koebnick C, Jung A, Croner RS, Brabletz T, Günther K, Kirchner T, Hahn EG, Hohenberger W, Becker H, Reingruber B (2004) Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine. Cancer Lett 203:181–190</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.canlet.2003.08.013" data-track-item_id="10.1016/j.canlet.2003.08.013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.canlet.2003.08.013" aria-label="Article reference 62" data-doi="10.1016/j.canlet.2003.08.013">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14732226" aria-label="PubMed reference 62">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2cXjsV2ktA%3D%3D" aria-label="CAS reference 62">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 62" href="http://scholar.google.com/scholar_lookup?&title=Prognostic%20significance%20of%20microsatellite%20instability%20in%20curatively%20resected%20adenocarcinoma%20of%20the%20small%20intestine&journal=Cancer%20Lett&doi=10.1016%2Fj.canlet.2003.08.013&volume=203&pages=181-190&publication_year=2004&author=Brueckl%2CWM&author=Heinze%2CE&author=Milsmann%2CC&author=Wein%2CA&author=Koebnick%2CC&author=Jung%2CA&author=Croner%2CRS&author=Brabletz%2CT&author=G%C3%BCnther%2CK&author=Kirchner%2CT&author=Hahn%2CEG&author=Hohenberger%2CW&author=Becker%2CH&author=Reingruber%2CB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="63."><p class="c-article-references__text" id="ref-CR63">Martin JA, Haber GB (2003) Ampullary adenoma: clinical manifestations, diagnosis, and treatment. Gastrointest Endosc Clin N Am 13:649–669</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S1052-5157(03)00101-6" data-track-item_id="10.1016/S1052-5157(03)00101-6" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS1052-5157%2803%2900101-6" aria-label="Article reference 63" data-doi="10.1016/S1052-5157(03)00101-6">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14986792" aria-label="PubMed reference 63">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 63" href="http://scholar.google.com/scholar_lookup?&title=Ampullary%20adenoma%3A%20clinical%20manifestations%2C%20diagnosis%2C%20and%20treatment&journal=Gastrointest%20Endosc%20Clin%20N%20Am&doi=10.1016%2FS1052-5157%2803%2900101-6&volume=13&pages=649-669&publication_year=2003&author=Martin%2CJA&author=Haber%2CGB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="64."><p class="c-article-references__text" id="ref-CR64">Patel R, Varadarajulu S, Wilcox CM (2012) Endoscopic ampullectomy: techniques and outcomes. J Clin Gastroenterol 46:8–15</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/MCG.0b013e318233a844" data-track-item_id="10.1097/MCG.0b013e318233a844" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FMCG.0b013e318233a844" aria-label="Article reference 64" data-doi="10.1097/MCG.0b013e318233a844">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22064552" aria-label="PubMed reference 64">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC38XjtF2nsrk%3D" aria-label="CAS reference 64">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 64" href="http://scholar.google.com/scholar_lookup?&title=Endoscopic%20ampullectomy%3A%20techniques%20and%20outcomes&journal=J%20Clin%20Gastroenterol&doi=10.1097%2FMCG.0b013e318233a844&volume=46&pages=8-15&publication_year=2012&author=Patel%2CR&author=Varadarajulu%2CS&author=Wilcox%2CCM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="65."><p class="c-article-references__text" id="ref-CR65">Cheng CL, Sherman S, Fogel EL, McHenry L, Watkins JL, Fukushima T, Howard TJ, Lazzell-Pannell L, Lehman GA (2004) Endoscopic snare papillectomy for tumors of the duodenal papillae. Gastrointest Endosc 60:757–764</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0016-5107(04)02029-2" data-track-item_id="10.1016/S0016-5107(04)02029-2" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0016-5107%2804%2902029-2" aria-label="Article reference 65" data-doi="10.1016/S0016-5107(04)02029-2">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15557951" aria-label="PubMed reference 65">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 65" href="http://scholar.google.com/scholar_lookup?&title=Endoscopic%20snare%20papillectomy%20for%20tumors%20of%20the%20duodenal%20papillae&journal=Gastrointest%20Endosc&doi=10.1016%2FS0016-5107%2804%2902029-2&volume=60&pages=757-764&publication_year=2004&author=Cheng%2CCL&author=Sherman%2CS&author=Fogel%2CEL&author=McHenry%2CL&author=Watkins%2CJL&author=Fukushima%2CT&author=Howard%2CTJ&author=Lazzell-Pannell%2CL&author=Lehman%2CGA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="66."><p class="c-article-references__text" id="ref-CR66">Bellizi et al (2009) The assessmentof specimens procured by endoscopic ampullectomy. Am J Clin Path 132:506–531</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1309/AJCPUZWJ8WA2IHBG" data-track-item_id="10.1309/AJCPUZWJ8WA2IHBG" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1309%2FAJCPUZWJ8WA2IHBG" aria-label="Article reference 66" data-doi="10.1309/AJCPUZWJ8WA2IHBG">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 66" href="http://scholar.google.com/scholar_lookup?&title=The%20assessmentof%20specimens%20procured%20by%20endoscopic%20ampullectomy&journal=Am%20J%20Clin%20Path&doi=10.1309%2FAJCPUZWJ8WA2IHBG&volume=132&pages=506-531&publication_year=2009"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="67."><p class="c-article-references__text" id="ref-CR67">Han J, Kim MH (2006) Endoscopic papillectomy for adenomas of the major duodenal papilla (with video). Gastrointest Endosc 63:292–301</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.gie.2005.07.022" data-track-item_id="10.1016/j.gie.2005.07.022" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.gie.2005.07.022" aria-label="Article reference 67" data-doi="10.1016/j.gie.2005.07.022">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16427938" aria-label="PubMed reference 67">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 67" href="http://scholar.google.com/scholar_lookup?&title=Endoscopic%20papillectomy%20for%20adenomas%20of%20the%20major%20duodenal%20papilla%20%28with%20video%29&journal=Gastrointest%20Endosc&doi=10.1016%2Fj.gie.2005.07.022&volume=63&pages=292-301&publication_year=2006&author=Han%2CJ&author=Kim%2CMH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="68."><p class="c-article-references__text" id="ref-CR68">Yamaguchi K, Enjoji M, Kitamura K (1990) Endoscopic biopsy has limited accuracy in diagnosis of ampullary tumors. Gastrointest Endosc 36:588–592</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0016-5107(90)71170-4" data-track-item_id="10.1016/S0016-5107(90)71170-4" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0016-5107%2890%2971170-4" aria-label="Article reference 68" data-doi="10.1016/S0016-5107(90)71170-4">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2279648" aria-label="PubMed reference 68">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK3M7it1Gltg%3D%3D" aria-label="CAS reference 68">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 68" href="http://scholar.google.com/scholar_lookup?&title=Endoscopic%20biopsy%20has%20limited%20accuracy%20in%20diagnosis%20of%20ampullary%20tumors&journal=Gastrointest%20Endosc&doi=10.1016%2FS0016-5107%2890%2971170-4&volume=36&pages=588-592&publication_year=1990&author=Yamaguchi%2CK&author=Enjoji%2CM&author=Kitamura%2CK"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="69."><p class="c-article-references__text" id="ref-CR69">Kahaleh M, Shami VM, Brock A, Conaway MR, Yoshida C, Moskaluk CA, Adams RB, Tokar J, Yeaton P (2004) Factors predictive of malignancy and endoscopic resectability in ampullary neoplasia. Am J Gastroenterol 99:2335–2339</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1572-0241.2004.40391.x" data-track-item_id="10.1111/j.1572-0241.2004.40391.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1572-0241.2004.40391.x" aria-label="Article reference 69" data-doi="10.1111/j.1572-0241.2004.40391.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15571579" aria-label="PubMed reference 69">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 69" href="http://scholar.google.com/scholar_lookup?&title=Factors%20predictive%20of%20malignancy%20and%20endoscopic%20resectability%20in%20ampullary%20neoplasia&journal=Am%20J%20Gastroenterol&doi=10.1111%2Fj.1572-0241.2004.40391.x&volume=99&pages=2335-2339&publication_year=2004&author=Kahaleh%2CM&author=Shami%2CVM&author=Brock%2CA&author=Conaway%2CMR&author=Yoshida%2CC&author=Moskaluk%2CCA&author=Adams%2CRB&author=Tokar%2CJ&author=Yeaton%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="70."><p class="c-article-references__text" id="ref-CR70">Heinrich S, Clavien PA (2010) Ampullary cancer. Curr Opin Gastroenterol 26:280–285</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/MOG.0b013e3283378eb0" data-track-item_id="10.1097/MOG.0b013e3283378eb0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FMOG.0b013e3283378eb0" aria-label="Article reference 70" data-doi="10.1097/MOG.0b013e3283378eb0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20168227" aria-label="PubMed reference 70">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 70" href="http://scholar.google.com/scholar_lookup?&title=Ampullary%20cancer&journal=Curr%20Opin%20Gastroenterol&doi=10.1097%2FMOG.0b013e3283378eb0&volume=26&pages=280-285&publication_year=2010&author=Heinrich%2CS&author=Clavien%2CPA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="71."><p class="c-article-references__text" id="ref-CR71">Ahn DW, Ryu JK, Kim J, Yoon WJ, Lee SH, Kim YT, Yoon YB (2013) Endoscopic papillectomy for benign ampullary neoplasms: how can treatment outcome be predicted? Gut Liver 7:239–245</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.5009/gnl.2013.7.2.239" data-track-item_id="10.5009/gnl.2013.7.2.239" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.5009%2Fgnl.2013.7.2.239" aria-label="Article reference 71" data-doi="10.5009/gnl.2013.7.2.239">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23560162" aria-label="PubMed reference 71">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607780" aria-label="PubMed Central reference 71">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 71" href="http://scholar.google.com/scholar_lookup?&title=Endoscopic%20papillectomy%20for%20benign%20ampullary%20neoplasms%3A%20how%20can%20treatment%20outcome%20be%20predicted%3F&journal=Gut%20Liver&doi=10.5009%2Fgnl.2013.7.2.239&volume=7&pages=239-245&publication_year=2013&author=Ahn%2CDW&author=Ryu%2CJK&author=Kim%2CJ&author=Yoon%2CWJ&author=Lee%2CSH&author=Kim%2CYT&author=Yoon%2CYB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="72."><p class="c-article-references__text" id="ref-CR72">Azih LC, Broussard BL, Phadnis MA, Heslin MJ, Eloubeidi MA, Varadarajulu S, Arnoletti JP (2013) Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas. World J Gastroenterol 19:511–515</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3748/wjg.v19.i4.511" data-track-item_id="10.3748/wjg.v19.i4.511" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3748%2Fwjg.v19.i4.511" aria-label="Article reference 72" data-doi="10.3748/wjg.v19.i4.511">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23382629" aria-label="PubMed reference 72">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558574" aria-label="PubMed Central reference 72">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 72" href="http://scholar.google.com/scholar_lookup?&title=Endoscopic%20ultrasound%20evaluation%20in%20the%20surgical%20treatment%20of%20duodenal%20and%20peri-ampullary%20adenomas&journal=World%20J%20Gastroenterol&doi=10.3748%2Fwjg.v19.i4.511&volume=19&pages=511-515&publication_year=2013&author=Azih%2CLC&author=Broussard%2CBL&author=Phadnis%2CMA&author=Heslin%2CMJ&author=Eloubeidi%2CMA&author=Varadarajulu%2CS&author=Arnoletti%2CJP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="73."><p class="c-article-references__text" id="ref-CR73">Ang DC, Shia J, Tang LH, Katabi N, Klimstra DS (2014) The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater. Am J Surg Pathol 38:1371–1379</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/PAS.0000000000000230" data-track-item_id="10.1097/PAS.0000000000000230" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FPAS.0000000000000230" aria-label="Article reference 73" data-doi="10.1097/PAS.0000000000000230">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24832159" aria-label="PubMed reference 73">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 73" href="http://scholar.google.com/scholar_lookup?&title=The%20utility%20of%20immunohistochemistry%20in%20subtyping%20adenocarcinoma%20of%20the%20ampulla%20of%20vater&journal=Am%20J%20Surg%20Pathol&doi=10.1097%2FPAS.0000000000000230&volume=38&pages=1371-1379&publication_year=2014&author=Ang%2CDC&author=Shia%2CJ&author=Tang%2CLH&author=Katabi%2CN&author=Klimstra%2CDS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="74."><p class="c-article-references__text" id="ref-CR74">Xue Y, Reid MD, Balci S, Quigley B, Muraki T, Memis B, Xia J, Hacihasanoglu E, Bedolla G, Pehlivanoglu B, Kim GE, Tajiri T, Ohike N, Aneja R, Krasinskas AM, Adsay V (2017) Immunohistochemical classification of ampullary carcinomas: critical reappraisal fails to confirm prognostic relevance for recently proposed panels, and highlights MUC5AC as a strong prognosticator. Am J Surg Pathol 41:865–876</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/PAS.0000000000000863" data-track-item_id="10.1097/PAS.0000000000000863" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FPAS.0000000000000863" aria-label="Article reference 74" data-doi="10.1097/PAS.0000000000000863">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=28505002" aria-label="PubMed reference 74">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 74" href="http://scholar.google.com/scholar_lookup?&title=Immunohistochemical%20classification%20of%20ampullary%20carcinomas%3A%20critical%20reappraisal%20fails%20to%20confirm%20prognostic%20relevance%20for%20recently%20proposed%20panels%2C%20and%20highlights%20MUC5AC%20as%20a%20strong%20prognosticator&journal=Am%20J%20Surg%20Pathol&doi=10.1097%2FPAS.0000000000000863&volume=41&pages=865-876&publication_year=2017&author=Xue%2CY&author=Reid%2CMD&author=Balci%2CS&author=Quigley%2CB&author=Muraki%2CT&author=Memis%2CB&author=Xia%2CJ&author=Hacihasanoglu%2CE&author=Bedolla%2CG&author=Pehlivanoglu%2CB&author=Kim%2CGE&author=Tajiri%2CT&author=Ohike%2CN&author=Aneja%2CR&author=Krasinskas%2CAM&author=Adsay%2CV"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="75."><p class="c-article-references__text" id="ref-CR75">Perysinakis I, Margaris I, Kouraklis G (2014) Ampullary cancer—a separate clinical entity? Histopathology 64:759–768</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/his.12324" data-track-item_id="10.1111/his.12324" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fhis.12324" aria-label="Article reference 75" data-doi="10.1111/his.12324">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24456259" aria-label="PubMed reference 75">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 75" href="http://scholar.google.com/scholar_lookup?&title=Ampullary%20cancer%E2%80%94a%20separate%20clinical%20entity%3F&journal=Histopathology&doi=10.1111%2Fhis.12324&volume=64&pages=759-768&publication_year=2014&author=Perysinakis%2CI&author=Margaris%2CI&author=Kouraklis%2CG"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="76."><p class="c-article-references__text" id="ref-CR76">Adsay V, Ohike N, Tajiri T, Kim GE, Krasinskas A, Balci S, Bagci P, Basturk O, Bandyopadhyay S, Jang KT, Kooby DA, Maithel SK, Sarmiento J, Staley CA, Gonzalez RS, Kong SY, Goodman M (2012) Ampullary region carcinomas: definition and site specific classification with delineation of four clinicopathologically and prognostically distinct subsets in an analysis of 249 cases. Am J Surg Pathol 36:1592–1608</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/PAS.0b013e31826399d8" data-track-item_id="10.1097/PAS.0b013e31826399d8" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FPAS.0b013e31826399d8" aria-label="Article reference 76" data-doi="10.1097/PAS.0b013e31826399d8">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23026934" aria-label="PubMed reference 76">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 76" href="http://scholar.google.com/scholar_lookup?&title=Ampullary%20region%20carcinomas%3A%20definition%20and%20site%20specific%20classification%20with%20delineation%20of%20four%20clinicopathologically%20and%20prognostically%20distinct%20subsets%20in%20an%20analysis%20of%20249%20cases&journal=Am%20J%20Surg%20Pathol&doi=10.1097%2FPAS.0b013e31826399d8&volume=36&pages=1592-1608&publication_year=2012&author=Adsay%2CV&author=Ohike%2CN&author=Tajiri%2CT&author=Kim%2CGE&author=Krasinskas%2CA&author=Balci%2CS&author=Bagci%2CP&author=Basturk%2CO&author=Bandyopadhyay%2CS&author=Jang%2CKT&author=Kooby%2CDA&author=Maithel%2CSK&author=Sarmiento%2CJ&author=Staley%2CCA&author=Gonzalez%2CRS&author=Kong%2CSY&author=Goodman%2CM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="77."><p class="c-article-references__text" id="ref-CR77">Aparicio T, Zaanan A, Svrcek M et al (2014) Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 46:97–104</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.dld.2013.04.013" data-track-item_id="10.1016/j.dld.2013.04.013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.dld.2013.04.013" aria-label="Article reference 77" data-doi="10.1016/j.dld.2013.04.013">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 77" href="http://scholar.google.com/scholar_lookup?&title=Small%20bowel%20adenocarcinoma%3A%20epidemiology%2C%20risk%20factors%2C%20diagnosis%20and%20treatment&journal=Digestive%20and%20liver%20disease%3A%20official%20journal%20of%20the%20Italian%20Society%20of%20Gastroenterology%20and%20the%20Italian%20Association%20for%20the%20Study%20of%20the%20Liver&doi=10.1016%2Fj.dld.2013.04.013&volume=46&pages=97-104&publication_year=2014&author=Aparicio%2CT&author=Zaanan%2CA&author=Svrcek%2CM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="78."><p class="c-article-references__text" id="ref-CR78">Bronsert P, Kohler I, Werner M, Makowiec F, Kuesters S, Hoeppner J, Hopt UT, Keck T, Bausch D, Wellner UF (2013) Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin. BMC Cancer 13(428)</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="79."><p class="c-article-references__text" id="ref-CR79">Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW (2008) Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg 207:210–218</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.jamcollsurg.2008.01.028" data-track-item_id="10.1016/j.jamcollsurg.2008.01.028" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.jamcollsurg.2008.01.028" aria-label="Article reference 79" data-doi="10.1016/j.jamcollsurg.2008.01.028">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18656049" aria-label="PubMed reference 79">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 79" href="http://scholar.google.com/scholar_lookup?&title=Tumors%20of%20the%20ampulla%20of%20vater%3A%20histopathologic%20classification%20and%20predictors%20of%20survival&journal=J%20Am%20Coll%20Surg&doi=10.1016%2Fj.jamcollsurg.2008.01.028&volume=207&pages=210-218&publication_year=2008&author=Carter%2CJT&author=Grenert%2CJP&author=Rubenstein%2CL&author=Stewart%2CL&author=Way%2CLW"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="80."><p class="c-article-references__text" id="ref-CR80">Chang DK, Jamieson NB, Johns AL, Scarlett CJ, Pajic M, Chou A, Pinese M, Humphris JL, Jones MD, Toon C, Nagrial AM, Chantrill LA, Chin VT, Pinho AV, Rooman I, Cowley MJ, Wu J, Mead RS, Colvin EK, Samra JS, Corbo V, Bassi C, Falconi M, Lawlor RT, Crippa S, Sperandio N, Bersani S, Dickson EJ, Mohamed MAA, Oien KA, Foulis AK, Musgrove EA, Sutherland RL, Kench JG, Carter CR, Gill AJ, Scarpa A, McKay CJ, Biankin AV (2013) Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater. J Clin Oncol 31:1348–1356</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1200/JCO.2012.46.8868" data-track-item_id="10.1200/JCO.2012.46.8868" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1200%2FJCO.2012.46.8868" aria-label="Article reference 80" data-doi="10.1200/JCO.2012.46.8868">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23439753" aria-label="PubMed reference 80">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 80" href="http://scholar.google.com/scholar_lookup?&title=Histomolecular%20phenotypes%20and%20outcome%20in%20adenocarcinoma%20of%20the%20ampulla%20of%20vater&journal=J%20Clin%20Oncol&doi=10.1200%2FJCO.2012.46.8868&volume=31&pages=1348-1356&publication_year=2013&author=Chang%2CDK&author=Jamieson%2CNB&author=Johns%2CAL&author=Scarlett%2CCJ&author=Pajic%2CM&author=Chou%2CA&author=Pinese%2CM&author=Humphris%2CJL&author=Jones%2CMD&author=Toon%2CC&author=Nagrial%2CAM&author=Chantrill%2CLA&author=Chin%2CVT&author=Pinho%2CAV&author=Rooman%2CI&author=Cowley%2CMJ&author=Wu%2CJ&author=Mead%2CRS&author=Colvin%2CEK&author=Samra%2CJS&author=Corbo%2CV&author=Bassi%2CC&author=Falconi%2CM&author=Lawlor%2CRT&author=Crippa%2CS&author=Sperandio%2CN&author=Bersani%2CS&author=Dickson%2CEJ&author=Mohamed%2CMAA&author=Oien%2CKA&author=Foulis%2CAK&author=Musgrove%2CEA&author=Sutherland%2CRL&author=Kench%2CJG&author=Carter%2CCR&author=Gill%2CAJ&author=Scarpa%2CA&author=McKay%2CCJ&author=Biankin%2CAV"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="81."><p class="c-article-references__text" id="ref-CR81">Kim WS, Choi DW, Choi SH, Heo JS, You DD, Lee HG (2012) Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer. J Surg Oncol 105:266–272</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/jso.22090" data-track-item_id="10.1002/jso.22090" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fjso.22090" aria-label="Article reference 81" data-doi="10.1002/jso.22090">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21882202" aria-label="PubMed reference 81">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 81" href="http://scholar.google.com/scholar_lookup?&title=Clinical%20significance%20of%20pathologic%20subtype%20in%20curatively%20resected%20ampulla%20of%20vater%20cancer&journal=J%20Surg%20Oncol&doi=10.1002%2Fjso.22090&volume=105&pages=266-272&publication_year=2012&author=Kim%2CWS&author=Choi%2CDW&author=Choi%2CSH&author=Heo%2CJS&author=You%2CDD&author=Lee%2CHG"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="82."><p class="c-article-references__text" id="ref-CR82">Kimura W, Futakawa N, Yamagata S, Wada Y, Kuroda A, Muto T, Esaki Y (1994) Different clinicopathologic findings in two histologic types of carcinoma of papilla of vater. Jpn J Cancer Res 85:161–166</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1349-7006.1994.tb02077.x" data-track-item_id="10.1111/j.1349-7006.1994.tb02077.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1349-7006.1994.tb02077.x" aria-label="Article reference 82" data-doi="10.1111/j.1349-7006.1994.tb02077.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7511574" aria-label="PubMed reference 82">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919425" aria-label="PubMed Central reference 82">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK2c7ptlCluw%3D%3D" aria-label="CAS reference 82">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 82" href="http://scholar.google.com/scholar_lookup?&title=Different%20clinicopathologic%20findings%20in%20two%20histologic%20types%20of%20carcinoma%20of%20papilla%20of%20vater&journal=Jpn%20J%20Cancer%20Res&doi=10.1111%2Fj.1349-7006.1994.tb02077.x&volume=85&pages=161-166&publication_year=1994&author=Kimura%2CW&author=Futakawa%2CN&author=Yamagata%2CS&author=Wada%2CY&author=Kuroda%2CA&author=Muto%2CT&author=Esaki%2CY"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="83."><p class="c-article-references__text" id="ref-CR83">Roh YH, Kim YH, Lee HW, Kim SJ, Roh MS, Jeong JS, Jung GJ (2007) The clinicopathologic and immunohistochemical characteristics of ampulla of vater carcinoma: the intestinal type is associated with a better prognosis. Hepato-Gastroenterology 54:1641–1644</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18019683" aria-label="PubMed reference 83">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 83" href="http://scholar.google.com/scholar_lookup?&title=The%20clinicopathologic%20and%20immunohistochemical%20characteristics%20of%20ampulla%20of%20vater%20carcinoma%3A%20the%20intestinal%20type%20is%20associated%20with%20a%20better%20prognosis&journal=Hepato-Gastroenterology&volume=54&pages=1641-1644&publication_year=2007&author=Roh%2CYH&author=Kim%2CYH&author=Lee%2CHW&author=Kim%2CSJ&author=Roh%2CMS&author=Jeong%2CJS&author=Jung%2CGJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="84."><p class="c-article-references__text" id="ref-CR84">Westgaard A, Pomianowska E, Clausen OP, Gladhaug IP (2013) Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies? Ann Surg Oncol 20:430–439</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1245/s10434-012-2603-0" data-track-item_id="10.1245/s10434-012-2603-0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1245%2Fs10434-012-2603-0" aria-label="Article reference 84" data-doi="10.1245/s10434-012-2603-0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22956064" aria-label="PubMed reference 84">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 84" href="http://scholar.google.com/scholar_lookup?&title=Intestinal-type%20and%20pancreatobiliary-type%20adenocarcinomas%3A%20how%20does%20ampullary%20carcinoma%20differ%20from%20other%20periampullary%20malignancies%3F&journal=Ann%20Surg%20Oncol&doi=10.1245%2Fs10434-012-2603-0&volume=20&pages=430-439&publication_year=2013&author=Westgaard%2CA&author=Pomianowska%2CE&author=Clausen%2COP&author=Gladhaug%2CIP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="85."><p class="c-article-references__text" id="ref-CR85">Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OPF, Gladhaug IP (2008) Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer 8(170)</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="86."><p class="c-article-references__text" id="ref-CR86">Zhou H, Schaefer N, Wolff M, Fischer HP (2004) Carcinoma of the ampulla of vater: comparative histologic/immunohistochemical classification and follow-up. Am J Surg Pathol 28:875–882</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/00000478-200407000-00005" data-track-item_id="10.1097/00000478-200407000-00005" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2F00000478-200407000-00005" aria-label="Article reference 86" data-doi="10.1097/00000478-200407000-00005">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15223956" aria-label="PubMed reference 86">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 86" href="http://scholar.google.com/scholar_lookup?&title=Carcinoma%20of%20the%20ampulla%20of%20vater%3A%20comparative%20histologic%2Fimmunohistochemical%20classification%20and%20follow-up&journal=Am%20J%20Surg%20Pathol&doi=10.1097%2F00000478-200407000-00005&volume=28&pages=875-882&publication_year=2004&author=Zhou%2CH&author=Schaefer%2CN&author=Wolff%2CM&author=Fischer%2CHP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="87."><p class="c-article-references__text" id="ref-CR87">Howe JR, Klimstra DS, Moccia RD, Conlon KC, Brennan MF (1998) Factors predictive of survival in ampullary carcinoma. Ann Surg 228:87–94</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/00000658-199807000-00013" data-track-item_id="10.1097/00000658-199807000-00013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2F00000658-199807000-00013" aria-label="Article reference 87" data-doi="10.1097/00000658-199807000-00013">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9671071" aria-label="PubMed reference 87">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1191432" aria-label="PubMed Central reference 87">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK1czjsVWntA%3D%3D" aria-label="CAS reference 87">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 87" href="http://scholar.google.com/scholar_lookup?&title=Factors%20predictive%20of%20survival%20in%20ampullary%20carcinoma&journal=Ann%20Surg&doi=10.1097%2F00000658-199807000-00013&volume=228&pages=87-94&publication_year=1998&author=Howe%2CJR&author=Klimstra%2CDS&author=Moccia%2CRD&author=Conlon%2CKC&author=Brennan%2CMF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="88."><p class="c-article-references__text" id="ref-CR88">Schueneman A, Goggins M, Ensor J, Saka B, Neishaboori N, Lee S, Maitra A, Varadhachary G, Rezaee N, Wolfgang C, Adsay V, Wang H, Overman MJ (2015) Validation of histomolecular classification utilizing histological subtype, muc1, and cdx2 for prognostication of resected ampullary adenocarcinoma. Br J Cancer 113:64–68</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/bjc.2015.172" data-track-item_id="10.1038/bjc.2015.172" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fbjc.2015.172" aria-label="Article reference 88" data-doi="10.1038/bjc.2015.172">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25989273" aria-label="PubMed reference 88">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647538" aria-label="PubMed Central reference 88">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC2MXht1elsrvP" aria-label="CAS reference 88">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 88" href="http://scholar.google.com/scholar_lookup?&title=Validation%20of%20histomolecular%20classification%20utilizing%20histological%20subtype%2C%20muc1%2C%20and%20cdx2%20for%20prognostication%20of%20resected%20ampullary%20adenocarcinoma&journal=Br%20J%20Cancer&doi=10.1038%2Fbjc.2015.172&volume=113&pages=64-68&publication_year=2015&author=Schueneman%2CA&author=Goggins%2CM&author=Ensor%2CJ&author=Saka%2CB&author=Neishaboori%2CN&author=Lee%2CS&author=Maitra%2CA&author=Varadhachary%2CG&author=Rezaee%2CN&author=Wolfgang%2CC&author=Adsay%2CV&author=Wang%2CH&author=Overman%2CMJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="89."><p class="c-article-references__text" id="ref-CR89">Schiergens TS, Reu S, Neumann J, Renz BW, Niess H, Boeck S, Heinemann V, Bruns CJ, Jauch KW, Kleespies A (2015) Histomorphologic and molecular phenotypes predict gemcitabine response and overall survival in adenocarcinoma of the ampulla of vater. Surgery 158:151–161</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.surg.2015.02.001" data-track-item_id="10.1016/j.surg.2015.02.001" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.surg.2015.02.001" aria-label="Article reference 89" data-doi="10.1016/j.surg.2015.02.001">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25819575" aria-label="PubMed reference 89">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 89" href="http://scholar.google.com/scholar_lookup?&title=Histomorphologic%20and%20molecular%20phenotypes%20predict%20gemcitabine%20response%20and%20overall%20survival%20in%20adenocarcinoma%20of%20the%20ampulla%20of%20vater&journal=Surgery&doi=10.1016%2Fj.surg.2015.02.001&volume=158&pages=151-161&publication_year=2015&author=Schiergens%2CTS&author=Reu%2CS&author=Neumann%2CJ&author=Renz%2CBW&author=Niess%2CH&author=Boeck%2CS&author=Heinemann%2CV&author=Bruns%2CCJ&author=Jauch%2CKW&author=Kleespies%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="90."><p class="c-article-references__text" id="ref-CR90">Amin Mb, ed. <i>AJCC cancer staging manual</i>, 2017, Springer</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="91."><p class="c-article-references__text" id="ref-CR91">Balachandran P, Sikora SS, Kapoor S, Krishnani N, Kumar A, Saxena R, Kapoor VK (2006) Long-term survival and recurrence patterns in ampullary cancer. Pancreas 32:390–395</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/01.mpa.0000220864.80034.63" data-track-item_id="10.1097/01.mpa.0000220864.80034.63" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2F01.mpa.0000220864.80034.63" aria-label="Article reference 91" data-doi="10.1097/01.mpa.0000220864.80034.63">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16670621" aria-label="PubMed reference 91">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 91" href="http://scholar.google.com/scholar_lookup?&title=Long-term%20survival%20and%20recurrence%20patterns%20in%20ampullary%20cancer&journal=Pancreas&doi=10.1097%2F01.mpa.0000220864.80034.63&volume=32&pages=390-395&publication_year=2006&author=Balachandran%2CP&author=Sikora%2CSS&author=Kapoor%2CS&author=Krishnani%2CN&author=Kumar%2CA&author=Saxena%2CR&author=Kapoor%2CVK"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="92."><p class="c-article-references__text" id="ref-CR92">Hsu HP, Yang TM, Hsieh YH, Shan YS, Lin PW (2007) Predictors for patterns of failure after pancreaticoduodenectomy in ampullary cancer. Ann Surg Oncol 14:50–60</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1245/s10434-006-9136-3" data-track-item_id="10.1245/s10434-006-9136-3" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1245%2Fs10434-006-9136-3" aria-label="Article reference 92" data-doi="10.1245/s10434-006-9136-3">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17054003" aria-label="PubMed reference 92">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 92" href="http://scholar.google.com/scholar_lookup?&title=Predictors%20for%20patterns%20of%20failure%20after%20pancreaticoduodenectomy%20in%20ampullary%20cancer&journal=Ann%20Surg%20Oncol&doi=10.1245%2Fs10434-006-9136-3&volume=14&pages=50-60&publication_year=2007&author=Hsu%2CHP&author=Yang%2CTM&author=Hsieh%2CYH&author=Shan%2CYS&author=Lin%2CPW"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="93."><p class="c-article-references__text" id="ref-CR93">Hsu HP, Shan YS, Hsieh YH, Yang TM, Lin PW (2007) Predictors of recurrence after pancreaticoduodenectomy in ampullary cancer: comparison between non-, early and late recurrence. J Formos Med Assoc 106:432–443</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0929-6646(09)60292-8" data-track-item_id="10.1016/S0929-6646(09)60292-8" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0929-6646%2809%2960292-8" aria-label="Article reference 93" data-doi="10.1016/S0929-6646(09)60292-8">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17588836" aria-label="PubMed reference 93">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2sXovFWksbw%3D" aria-label="CAS reference 93">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 93" href="http://scholar.google.com/scholar_lookup?&title=Predictors%20of%20recurrence%20after%20pancreaticoduodenectomy%20in%20ampullary%20cancer%3A%20comparison%20between%20non-%2C%20early%20and%20late%20recurrence&journal=J%20Formos%20Med%20Assoc&doi=10.1016%2FS0929-6646%2809%2960292-8&volume=106&pages=432-443&publication_year=2007&author=Hsu%2CHP&author=Shan%2CYS&author=Hsieh%2CYH&author=Yang%2CTM&author=Lin%2CPW"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="94."><p class="c-article-references__text" id="ref-CR94">Todoroki T, Koike N, Morishita Y, Kawamoto T, Ohkohchi N, Shoda J, Fukuda Y, Takahashi H (2003) Patterns and predictors of failure after curative resections of carcinoma of the ampulla of vater. Ann Surg Oncol 10:1176–1183</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1245/ASO.2003.07.512" data-track-item_id="10.1245/ASO.2003.07.512" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1245%2FASO.2003.07.512" aria-label="Article reference 94" data-doi="10.1245/ASO.2003.07.512">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14654474" aria-label="PubMed reference 94">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 94" href="http://scholar.google.com/scholar_lookup?&title=Patterns%20and%20predictors%20of%20failure%20after%20curative%20resections%20of%20carcinoma%20of%20the%20ampulla%20of%20vater&journal=Ann%20Surg%20Oncol&doi=10.1245%2FASO.2003.07.512&volume=10&pages=1176-1183&publication_year=2003&author=Todoroki%2CT&author=Koike%2CN&author=Morishita%2CY&author=Kawamoto%2CT&author=Ohkohchi%2CN&author=Shoda%2CJ&author=Fukuda%2CY&author=Takahashi%2CH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="95."><p class="c-article-references__text" id="ref-CR95">Kim RD, Kundhal PS, McGilvray ID et al (2006) Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma. J Am Coll Surg 202:112–119</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.jamcollsurg.2005.08.002" data-track-item_id="10.1016/j.jamcollsurg.2005.08.002" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.jamcollsurg.2005.08.002" aria-label="Article reference 95" data-doi="10.1016/j.jamcollsurg.2005.08.002">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16377504" aria-label="PubMed reference 95">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 95" href="http://scholar.google.com/scholar_lookup?&title=Predictors%20of%20failure%20after%20pancreaticoduodenectomy%20for%20ampullary%20carcinoma&journal=J%20Am%20Coll%20Surg&doi=10.1016%2Fj.jamcollsurg.2005.08.002&volume=202&pages=112-119&publication_year=2006&author=Kim%2CRD&author=Kundhal%2CPS&author=McGilvray%2CID"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="96."><p class="c-article-references__text" id="ref-CR96">Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, Wolfgang CL, Eckhauser F, Edil BH, Choti MA, Schulick RD, Pawlik TM (2010) Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointes Surg 14:379–387</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s11605-009-1080-7" data-track-item_id="10.1007/s11605-009-1080-7" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s11605-009-1080-7" aria-label="Article reference 96" data-doi="10.1007/s11605-009-1080-7">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 96" href="http://scholar.google.com/scholar_lookup?&title=Clinicopathologic%20analysis%20of%20ampullary%20neoplasms%20in%20450%20patients%3A%20implications%20for%20surgical%20strategy%20and%20long-term%20prognosis&journal=J%20Gastrointes%20Surg&doi=10.1007%2Fs11605-009-1080-7&volume=14&pages=379-387&publication_year=2010&author=Winter%2CJM&author=Cameron%2CJL&author=Olino%2CK&author=Herman%2CJM&author=de%20Jong%2CMC&author=Hruban%2CRH&author=Wolfgang%2CCL&author=Eckhauser%2CF&author=Edil%2CBH&author=Choti%2CMA&author=Schulick%2CRD&author=Pawlik%2CTM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="97."><p class="c-article-references__text" id="ref-CR97">Woo SM, Ryu JK, Lee SH, Yoo JW, Park JK, Kim YT, Jang JY, Kim SW, Kang GH, Yoon YB (2007) Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol 14:3195–3201</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1245/s10434-007-9537-y" data-track-item_id="10.1245/s10434-007-9537-y" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1245%2Fs10434-007-9537-y" aria-label="Article reference 97" data-doi="10.1245/s10434-007-9537-y">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17710498" aria-label="PubMed reference 97">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 97" href="http://scholar.google.com/scholar_lookup?&title=Recurrence%20and%20prognostic%20factors%20of%20ampullary%20carcinoma%20after%20radical%20resection%3A%20comparison%20with%20distal%20extrahepatic%20cholangiocarcinoma&journal=Ann%20Surg%20Oncol&doi=10.1245%2Fs10434-007-9537-y&volume=14&pages=3195-3201&publication_year=2007&author=Woo%2CSM&author=Ryu%2CJK&author=Lee%2CSH&author=Yoo%2CJW&author=Park%2CJK&author=Kim%2CYT&author=Jang%2CJY&author=Kim%2CSW&author=Kang%2CGH&author=Yoon%2CYB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="98."><p class="c-article-references__text" id="ref-CR98">Kang HJ, Eo SH, Kim SC, Park KM, Lee YJ, Lee SK, Yu E, Cho HJ, Hong SM (2014) Increased number of metastatic lymph nodes in adenocarcinoma of the ampulla of vater as a prognostic factor: a proposal of new nodal classification. Surgery 155:74–84</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.surg.2013.08.004" data-track-item_id="10.1016/j.surg.2013.08.004" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.surg.2013.08.004" aria-label="Article reference 98" data-doi="10.1016/j.surg.2013.08.004">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24238122" aria-label="PubMed reference 98">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 98" href="http://scholar.google.com/scholar_lookup?&title=Increased%20number%20of%20metastatic%20lymph%20nodes%20in%20adenocarcinoma%20of%20the%20ampulla%20of%20vater%20as%20a%20prognostic%20factor%3A%20a%20proposal%20of%20new%20nodal%20classification&journal=Surgery&doi=10.1016%2Fj.surg.2013.08.004&volume=155&pages=74-84&publication_year=2014&author=Kang%2CHJ&author=Eo%2CSH&author=Kim%2CSC&author=Park%2CKM&author=Lee%2CYJ&author=Lee%2CSK&author=Yu%2CE&author=Cho%2CHJ&author=Hong%2CSM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="99."><p class="c-article-references__text" id="ref-CR99">Ohike N, Coban I, Kim GE, Basturk O, Tajiri T, Krasinskas A, Bandyopadhyay S, Morohoshi T, Shimada Y, Kooby DA, Staley CA, Goodman M, Volkan Adsay N (2010) Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas. Am J Surg Pathol 34:1417–1424</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1097/PAS.0b013e3181f0b05a" data-track-item_id="10.1097/PAS.0b013e3181f0b05a" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1097%2FPAS.0b013e3181f0b05a" aria-label="Article reference 99" data-doi="10.1097/PAS.0b013e3181f0b05a">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20871215" aria-label="PubMed reference 99">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163902" aria-label="PubMed Central reference 99">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 99" href="http://scholar.google.com/scholar_lookup?&title=Tumor%20budding%20as%20a%20strong%20prognostic%20indicator%20in%20invasive%20ampullary%20adenocarcinomas&journal=Am%20J%20Surg%20Pathol&doi=10.1097%2FPAS.0b013e3181f0b05a&volume=34&pages=1417-1424&publication_year=2010&author=Ohike%2CN&author=Coban%2CI&author=Kim%2CGE&author=Basturk%2CO&author=Tajiri%2CT&author=Krasinskas%2CA&author=Bandyopadhyay%2CS&author=Morohoshi%2CT&author=Shimada%2CY&author=Kooby%2CDA&author=Staley%2CCA&author=Goodman%2CM&author=Volkan%20Adsay%2CN"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="100."><p class="c-article-references__text" id="ref-CR100">Bhatia S, Miller RC, Haddock MG, Donohue JH, Krishnan S (2006) Adjuvant therapy for ampullary carcinomas: the mayo clinic experience. Int J Radiat Oncol Biol Phys 66:514–519</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.ijrobp.2006.04.018" data-track-item_id="10.1016/j.ijrobp.2006.04.018" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.ijrobp.2006.04.018" aria-label="Article reference 100" data-doi="10.1016/j.ijrobp.2006.04.018">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16863684" aria-label="PubMed reference 100">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 100" href="http://scholar.google.com/scholar_lookup?&title=Adjuvant%20therapy%20for%20ampullary%20carcinomas%3A%20the%20mayo%20clinic%20experience&journal=Int%20J%20Radiat%20Oncol%20Biol%20Phys&doi=10.1016%2Fj.ijrobp.2006.04.018&volume=66&pages=514-519&publication_year=2006&author=Bhatia%2CS&author=Miller%2CRC&author=Haddock%2CMG&author=Donohue%2CJH&author=Krishnan%2CS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="101."><p class="c-article-references__text" id="ref-CR101">Lee JH, Whittington R, Williams NN, Berry MF, Vaughn DJ, Haller DG, Rosato EF (2000) Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas. Int J Radiat Oncol Biol Phys 47:945–953</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0360-3016(00)00537-X" data-track-item_id="10.1016/S0360-3016(00)00537-X" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0360-3016%2800%2900537-X" aria-label="Article reference 101" data-doi="10.1016/S0360-3016(00)00537-X">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10863064" aria-label="PubMed reference 101">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3czitlagsQ%3D%3D" aria-label="CAS reference 101">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 101" href="http://scholar.google.com/scholar_lookup?&title=Outcome%20of%20pancreaticoduodenectomy%20and%20impact%20of%20adjuvant%20therapy%20for%20ampullary%20carcinomas&journal=Int%20J%20Radiat%20Oncol%20Biol%20Phys&doi=10.1016%2FS0360-3016%2800%2900537-X&volume=47&pages=945-953&publication_year=2000&author=Lee%2CJH&author=Whittington%2CR&author=Williams%2CNN&author=Berry%2CMF&author=Vaughn%2CDJ&author=Haller%2CDG&author=Rosato%2CEF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="102."><p class="c-article-references__text" id="ref-CR102">Kim K, Chie EK, Jang JY, Kim SW, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW (2009) Role of adjuvant chemoradiotherapy for ampulla of vater cancer. Int J Radiat Oncol Biol Phys 75:436–441</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.ijrobp.2008.11.067" data-track-item_id="10.1016/j.ijrobp.2008.11.067" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.ijrobp.2008.11.067" aria-label="Article reference 102" data-doi="10.1016/j.ijrobp.2008.11.067">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19394162" aria-label="PubMed reference 102">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1MXhtV2ktrnP" aria-label="CAS reference 102">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 102" href="http://scholar.google.com/scholar_lookup?&title=Role%20of%20adjuvant%20chemoradiotherapy%20for%20ampulla%20of%20vater%20cancer&journal=Int%20J%20Radiat%20Oncol%20Biol%20Phys&doi=10.1016%2Fj.ijrobp.2008.11.067&volume=75&pages=436-441&publication_year=2009&author=Kim%2CK&author=Chie%2CEK&author=Jang%2CJY&author=Kim%2CSW&author=Oh%2CDY&author=Im%2CSA&author=Kim%2CTY&author=Bang%2CYJ&author=Ha%2CSW"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="103."><p class="c-article-references__text" id="ref-CR103">Palta M, Patel P, Broadwater G, Willett C, Pepek J, Tyler D, Zafar SY, Uronis H, Hurwitz H, White R, Czito B (2012) Carcinoma of the ampulla of vater: patterns of failure following resection and benefit of chemoradiotherapy. Ann Surg Oncol 19:1535–1540</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1245/s10434-011-2117-1" data-track-item_id="10.1245/s10434-011-2117-1" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1245%2Fs10434-011-2117-1" aria-label="Article reference 103" data-doi="10.1245/s10434-011-2117-1">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22045467" aria-label="PubMed reference 103">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 103" href="http://scholar.google.com/scholar_lookup?&title=Carcinoma%20of%20the%20ampulla%20of%20vater%3A%20patterns%20of%20failure%20following%20resection%20and%20benefit%20of%20chemoradiotherapy&journal=Ann%20Surg%20Oncol&doi=10.1245%2Fs10434-011-2117-1&volume=19&pages=1535-1540&publication_year=2012&author=Palta%2CM&author=Patel%2CP&author=Broadwater%2CG&author=Willett%2CC&author=Pepek%2CJ&author=Tyler%2CD&author=Zafar%2CSY&author=Uronis%2CH&author=Hurwitz%2CH&author=White%2CR&author=Czito%2CB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="104."><p class="c-article-references__text" id="ref-CR104">Jabbour SK, Mulvihill D (2014) Defining the role of adjuvant therapy: ampullary and duodenal adenocarcinoma. Semin Radiat Oncol 24:85–93</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.semradonc.2013.11.001" data-track-item_id="10.1016/j.semradonc.2013.11.001" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.semradonc.2013.11.001" aria-label="Article reference 104" data-doi="10.1016/j.semradonc.2013.11.001">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24635865" aria-label="PubMed reference 104">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 104" href="http://scholar.google.com/scholar_lookup?&title=Defining%20the%20role%20of%20adjuvant%20therapy%3A%20ampullary%20and%20duodenal%20adenocarcinoma&journal=Semin%20Radiat%20Oncol&doi=10.1016%2Fj.semradonc.2013.11.001&volume=24&pages=85-93&publication_year=2014&author=Jabbour%2CSK&author=Mulvihill%2CD"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="105."><p class="c-article-references__text" id="ref-CR105">Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW, European Study Group for Pancreatic Cancer (2012) Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA 308:147–156</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="106."><p class="c-article-references__text" id="ref-CR106">Hechtman JF, Liu W, Sadowska J, Zhen L, Borsu L, Arcila ME, Won HH, Shah RH, Berger MF, Vakiani E, Shia J, Klimstra DS (2015) Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of erbb2 (her2). Mod Pathol 28:1123–1129</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/modpathol.2015.57" data-track-item_id="10.1038/modpathol.2015.57" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fmodpathol.2015.57" aria-label="Article reference 106" data-doi="10.1038/modpathol.2015.57">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25975284" aria-label="PubMed reference 106">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977532" aria-label="PubMed Central reference 106">PubMed Central</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BC2MXht1KiurvF" aria-label="CAS reference 106">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 106" href="http://scholar.google.com/scholar_lookup?&title=Sequencing%20of%20279%20cancer%20genes%20in%20ampullary%20carcinoma%20reveals%20trends%20relating%20to%20histologic%20subtypes%20and%20frequent%20amplification%20and%20overexpression%20of%20erbb2%20%28her2%29&journal=Mod%20Pathol&doi=10.1038%2Fmodpathol.2015.57&volume=28&pages=1123-1129&publication_year=2015&author=Hechtman%2CJF&author=Liu%2CW&author=Sadowska%2CJ&author=Zhen%2CL&author=Borsu%2CL&author=Arcila%2CME&author=Won%2CHH&author=Shah%2CRH&author=Berger%2CMF&author=Vakiani%2CE&author=Shia%2CJ&author=Klimstra%2CDS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="107."><p class="c-article-references__text" id="ref-CR107">Alvi MA, McArt DG, Kelly P, Fuchs MA, Alderdice M, McCabe C, Bingham V, McGready C, Tripathi S, Emmert-Streib F, Loughrey MB, McQuaid S, Maxwell P, Hamilton PW, Turkington R, James JA, Wilson RH, Salto-Tellez M (2015) Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility. 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Primary small bowel adenomas and adenocarcinomas—recent advances. <i>Virchows Arch</i> <b>473</b>, 265–273 (2018). https://doi.org/10.1007/s00428-018-2400-7</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1007/s00428-018-2400-7?format=refman&flavour=citation">Download citation<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p><ul class="c-bibliographic-information__list" data-test="publication-history"><li class="c-bibliographic-information__list-item"><p>Received<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2017-11-24">24 November 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