Immunotherapy can prevent dangerous blood transfusion in foetus

<!DOCTYPE html> <html lang="en" dir="ltr"> <head> <meta charset="utf-8" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/themes/custom/drupack/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="alternate" hreflang="en" href="https://www.uzleuven.be/en/news/immunotherapy-can-prevent-dangerous-blood-transfusion-foetus" /> <link rel="alternate" hreflang="nl" href="https://www.uzleuven.be/nl/nieuws/immunotherapie-kan-gevaarlijke-bloedtransfusie-bij-foetus-voorkomen" /> <link rel="dns-prefetch" href="https://www.googletagmanager.com"> <link rel="dns-prefetch" href="https://wmimages.uzleuven.be"> <link rel="dns-prefetch" href="https://assets.uzleuven.be"> <title>Immunotherapy can prevent dangerous blood transfusion in foetus | UZ Leuven</title> <meta name="twitter:card" content="summary" /> <meta property="og:title" content="Immunotherapy can prevent dangerous blood transfusion in foetus" /> <meta name="description" content="A new study shows that the drug nipocalimab is a good alternative for the not harmless blood transfusion in a rhesus pregnancy: the drug ensures that the mother's antibodies can no longer go to the foetus. " /> <meta property="og:description" content="A new study shows that the drug nipocalimab is a good alternative for the not harmless blood transfusion in a rhesus pregnancy: the drug ensures that the mother's antibodies can no longer go to the foetus. 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This might cause issues with some parts of the website. Please update to the most recent version of your browser, or use another browser like <a data-fragment="" href="https://www.google.nl/intl/nl/chrome/?brand=CHBD&gclsrc=aw.ds&&gclid=EAIaIQobChMI5sqI8cj76AIV2eR3Ch31RA_tEAAYASAAEgLILPD_BwE">Google Chrome</a>.</p> </div> </div> </div> </div> </div> <main class="l-page__content"> <div data-drupal-messages-fallback class="hidden"></div> <nav class="breadcrumb hero__breadcrumb" aria-label="Breadcrumb"> <ol class="breadcrumb__list"> <li class="breadcrumb__item"><a class="breadcrumb__link" href="/en"><span class="breadcrumb__link__text">Home</span></a> <span class="breadcrumb__icon" aria-hidden="true"></span> </li> <li class="breadcrumb__item"><a class="breadcrumb__link" href="/en/news"><span class="breadcrumb__link__text">News</span></a> </li> <li class="breadcrumb__item"> <a class="visually-hidden" aria-current="page">Immunotherapy can prevent dangerous blood transfusion in foetus</a></li> </ol> </nav> <header class="hero is-none"> <div class="hero__content"> <h1 class="hero__title header-hero "> <span class="hero__title__text">Immunotherapy can prevent dangerous blood transfusion in foetus</span> </h1> <div class="hero__date meta">8 August 2024</div> <div class="hero__intro text ">A new study shows that the drug nipocalimab is a good alternative for the not harmless blood transfusion in a rhesus pregnancy: the drug ensures that the mother's antibodies can no longer go to the foetus. </div> </div> </header> <div class="l-content"> <article class="l-content__cbs "> <div class="cbs "> <div id="4db9a459-22fe-46ab-a404-aa1193a58943" class="block--text text"> <p>In rhesus pregnancy, antibodies from the pregnant mother can lead to anaemia for the foetus in the uterus. To treat anaemia, doctors today give blood transfusion to the foetus through the umbilical cord. This is a delicate procedure that requires quite some specialist experience. A new study show that the drug nipocalimab is a good alternative. The results of the phase 2 trial were recently published in the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2314466" target="_blank" rel="noreferrer noopener">New England Journal of Medicine</a>. <br><br>UZ Leuven was one of the 20 hospitals that tested the new drug in pregnant mothers that had already suffered a problematic rhesus pregnancy before. In 7 of the 14 women that were monitored the baby did not life in the the previous pregnancies. After treatment with the drug nipocalimab 13 out of the 14 babies survived: a very good result, especially if you know that rhesus disease and the immunity problem usually get worse in ever pregnancy.  </p> </div> <blockquote class="quote" id="the-drug-can-become-the-first-non-surgical-treatment-for-rhesus-pregnancies"> <div class="quote__content "> <svg class="quote__quotemark" width="50" height="36" xmlns="http://www.w3.org/2000/svg"><path d="M10.976 13.09c6.034 0 10.926 5.13 10.926 11.455C21.902 30.872 17.01 36 10.976 36 4.94 36 .049 30.872.049 24.545L0 22.91C0 10.257 9.784 0 21.854 0v6.545c-4.17 0-8.09 1.703-11.038 4.793a16.413 16.413 0 0 0-1.553 1.893c.558-.092 1.13-.14 1.713-.14zm28.097 0C45.108 13.09 50 18.22 50 24.546 50 30.872 45.108 36 39.073 36c-6.034 0-10.927-5.128-10.927-11.455l-.048-1.636C28.098 10.257 37.882 0 49.95 0v6.545c-4.17 0-8.09 1.703-11.038 4.793a16.404 16.404 0 0 0-1.552 1.893c.558-.092 1.13-.14 1.712-.14z" fill="#007ACC" fill-rule="nonzero"/></svg> <div class="quote__text"> The drug can become the first non-surgical treatment for rhesus pregnancies </div> <img class="quote__img quote__img--no-crop" src="https://wmimages.uzleuven.be/styles/1d41396c1273794b4b4f4759cfde2dfc2f9128dd/2024-08/roland_devlieger.jpg?style=W3sianBlZyI6eyJxdWFsaXR5Ijo3NX19LHsicmVzaXplIjp7ImZpdCI6ImNvdmVyIiwid2lkdGgiOjI0MCwiaGVpZ2h0IjoyNDAsImdyYXZpdHkiOiJjZW50ZXIiLCJ3aXRob3V0RW5sYXJnZW1lbnQiOnRydWV9fV0=&sign=80d4a8702ec97049b25145fa82cc14b6819eb659128147a1049538090a6dff54" /> <div class="quote__source">prof. dr. Roland Devlieger</div> </div> </blockquote> <div id="8551f294-74bf-457f-8f0d-64a3f2ffb8f9" class="block--text text"> <p>Nipocalimab is a biochemical antibody that resembles human antibodies. It has the ability to readily bind to cells in the layers of the placenta, thus retaining the mother's antibodies and preventing them from entering the uterus. The results of the phase 2 study are encouraging for the phase 3 study that will now be started. In the new study, in which UZ Leuven is also participating, people with milder form of rhesus pregnancies will also receive the product and be compared with pregnant women who receive a placebo drug during a rhesus pregnancy. Any woman who already had a rhesus pregnancy in the past with at least 1 blood transfusion to the uterus is eligible to participate in the study. If the product can be approved after that phase 3 study, it could be the first non-surgical treatment for rhesus pregnancies.</p><h4>Game changer</h4><p><strong>Prof. dr. Roland Devlieger</strong>, gynaecologist at UZ Leuven: “It is the first time that we have found a drug that can prevent the mother's antibodies to transfer to the foetus. A rhesus pregnancy continues to be be dangerous disorder. In Belgium we screeb every pregnant woman for antibodies and and we can intervene in time to prevent severe anaemia and death of the baby. But in some countries it remains an important health problem. What's more, a blood transfusion remains a a delicate procedure that can only be performed in specialised hospitals with experienced doctors. The excellent results of immunotherapy with nipocalimab can therefore be a game changer for the follow-up of women with a rhesus pregnancy.”</p> </div> <div id="ec6d916a-b1e8-40b5-87b0-612f7502b181" class="block--text text"> <p>Also in other foetal diseases caused by the wrong combination of antibodies in the foetus and the mother, this kind of immunotherapy may be important, for example in incompatible maternal and foetal platelets or in congenital foetal heart disease. UZ Leuven will participate in follow-up studies for both rhesus pregnancies and incompatible platelets. <br><br>Read the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2314466" target="_blank" rel="noreferrer noopener">study in the New England Journal of Medicine</a>.</p> </div> <div id="feedback" data-i18n="{"formSource":"node:d1041a47-f08d-4f2c-8fa7-8af06637a082","done":"Thanks for your feedback.","title":"Remarks about this page?","button_yes":"Let us know","email_label":"Email","feedback_label":"Feedback","submit_label":"Submit feedback","error_messages":{"required":"This field is required.","email":"Invalid email.","min_char":"At least 20 characters are required."},"description":"For personal medical enquiries, you have to make an appointment with a physician."}"></div> <div class="meta"> Last edit: 9 August 2024 </div> </div> </article> </div> </main> <footer> <div class="footer"> <div class="footer__row"> <div class="footer__inside"> <div class="footer__columns"> <div class="footer__column"> <h4 class="footer__heading heading-3">Contact</h4> <p><a href="tel:+3216332211" target="_blank" rel="noreferrer noopener">+32 16 33 22 11</a></p> <p>Herestraat 49, 3000 Leuven, Belgium</p> <p><a href="/en/node/13495">All contact information</a></p> <div class="social-list"> <span class="social-list__title">Also find us on:</span> <ul class="list horizontal-list is-small"> <li> <a class="footer__social icon--facebook" href="https://www.facebook.com/uzleuven" target="_blank" rel="noopener noreferrer"> <svg width="24" height="24"><use xlink:href="#facebook"></use></svg> <span class="visually-hidden">Facebook</span> </a> </li> <li> <a class="footer__social icon--twitter" href="https://twitter.com/uzleuven" target="_blank" rel="noopener noreferrer"> <svg width="24" height="24"><use xlink:href="#twitter"></use></svg> <span class="visually-hidden">Twitter</span> </a> </li> <li> <a class="footer__social icon--linkedin" href="https://www.linkedin.com/company/uz-leuven" target="_blank" rel="noopener noreferrer"> <svg width="24" height="24"><use xlink:href="#linkedin"></use></svg> <span class="visually-hidden">LinkedIn</span> </a> </li> </ul> </div> </div> <div class="footer__column"> <h4 class="footer__heading heading-3"> <a class="heading-link" href="/en/consultation-and-admission"><span class="heading-link__text">Consultation and admission</span></a> </h4> <ul class="list"> <li> <a href="/en/consultation-and-admission/consultation-and-function-tests">Consultation</a> </li> <li> <a href="/en/consultation-and-admission/admission">Admission</a> </li> <li> <a href="/en/visits">Visiting hours</a> </li> <li> <a href="/en/greeting-card">Send a greeting card</a> </li> </ul> </div> <div class="footer__column"> <h4 class="footer__heading heading-3"> <a class="heading-link" href="/en/about-us"><span class="heading-link__text">About UZ Leuven</span></a> </h4> <ul class="list"> <li> <a href="/en/news-and-calendar">News and publications</a> </li> <li> <a href="/en/press-and-media">For press and media</a> </li> </ul> </div> </div> </div> </div> <div class="footer__row"> <div class="footer__inside"> <div class="footer__logos footer__columns"></div> </div> </div> </div> <div class="closure"> <div class="closure__inside"> <div class="closure__content"> <ul class="list horizontal-list is-nav closure__links" id="closure"> <li class="closure__item"><a class="closure__link" href="/en/cookie-policy">Cookie policy</a></li> <li class="closure__item"><a class="closure__link" href="/en/privacy-and-your-patient-record">Privacy</a></li> </ul> </div> <div class="closure__wieni"> <a class="wieni" href="https://www.wieni.be" target="_blank" title="site by wieni" rel="noopener noreferrer"> <svg class="wieni__logo" width="61" height="22"><use xlink:href="#wieni"></use></svg> </a> </div> </div> </div> </footer> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"en\/","currentPath":"node\/21577","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"wmcustom_urls":{"search":"\/en\/search"},"analytics":{"nodeType":"Nieuws","isMedischeDienst":0},"outdatedBrowser":{"title":"Your browser is out-of-date","message":"\u003Cp\u003EIt seems you\u0027re using an outdated version of browser-name. 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Immunotherapy can prevent dangerous blood transfusion in foetus | UZ Leuven