Human p300 Antibody (AF3789) by R&D Systems, Part of Bio-Techne

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<div id="product-page-details" data-template_in_use="antibody_template" data-time_total="1.228786945343" data-time_to_compile="0.087378025054932" data-time_to_build="0.86219096183777" data-time_datapoints="0.27921795845032" data-time_template="-0.27921795845032" data-time_post_epcc="0.9495689868927" data-time_epcc="0.27921795845032" data-render_time="Sunday 16th of February 2025 06:25:29 AM" data-fallback="FALSE" data-time_to_process_data="0.13622689247131" class="px-4 container" class="container"> <div id="above-fold-section"> <div class="mb-2 o__product-summary"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="validation-badges-header-wrapper"> <a class="biological-validation mr-3 d-inline-flex mt-1" href="/reagents/antibodies/antibody-validation" target="_blank" title="Biological Validation"></a> </div> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Human p300 Antibody </h1> <h2 class="font-weight-normal h4"> R&D Systems, part of Bio-Techne | Catalog # <span id="product-code" class="font-weight-bold">AF3789</span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div id="submit_review_wrapper" class="col-auto d-flex align-self-center"> <div id="submit_review"> <a href="/reviews/AF3789" class="submit_review" rel="nofollow"> <span class="icon-plus-circle d-none d-lg-inline pr-1"></span> Submit a review </a> </div> </div> <div id="citation_quick_link_wrapper" class="col-auto d-flex align-self-center"> <div id="citation_quicklink"> <a href="#citations" id="citation_count" data-tab="2" class="citations"> <span class="icon-icon-product-citations d-none d-lg-inline pr-1"></span> Citations (1)  </a> </div> </div> <div class="col-auto d-flex align-self-center"> <div> <div class="px-0 my-1" id="datasheet-summary-wrapper" data-section="section-base--top-jumplink"> <article class="top-jumplink-wrapper"> <span class="icon-icon-pdf text-error-red"></span> <a href="#product-documents" class="product-documents-top-link" rel="nofollow">Product Datasheet / COA / SDS</a> </article> </div> </div> </div> </div> </div> <div id="new_version_available"> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" alt="R&D Systems, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> <div class="row border-top mb-2" id="images-orderdetail-wrapper"> <div class="col-xl-6 mt-2" id="images-wrapper" data-section="image_summary"> <div id="image-tree" data-section="component-product-image-tree" class="vertical lightbox" data-mdb-zoom-effect="true"> <div id="product-image-gallery" class="row"> <div class="col-md-2 d-none d-md-block"> <ul class="list-inline m-0"> <li data-id="1" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Chromatin_Immunoprecipitation_11239.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Chromatin_Immunoprecipitation_11239.jpg" alt="Detection of p300-regulated Genes antibody by Chromatin Immunoprecipitation." title="Detection of p300-regulated Genes by Chromatin Immunoprecipitation." data-caption="Jurkat human acute T cell leukemia cell line treated with 50 ng/mL PMA and 200 ng/mL calcium ionomycin for 30 minutes was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. p300/DNA complexes were immunoprecipitated using 5 µg Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) or control antibody (Catalog # <a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/donkey-anti-goat-igg-biotinylated-antibody_baf109" target="_self">BAF109</a>). Immunocomplexes were captured using 50 µL of MagCellect Streptavidin Ferrofluid (Catalog # MAG999) and DNA was purified using chelating resin solution. The<em>fos</em>promoter was detected by standard PCR." data-badges='<span class="biological-validation"></span>' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Chromatin_Immunoprecipitation_11239.jpg" data-id="0" data-application="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Chromatin_Immunoprecipitation_11239.jpg" data-header="Human p300 Antibody, Catalog # AF3789" class="lazy" /> </div> </li> <li data-id="2" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunocytochemistry__Immunofluorescence_20772.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunocytochemistry__Immunofluorescence_20772.jpg" alt="p300 antibody in HeLa Human Cell Line by Immunocytochemistry (ICC)." title="p300 in HeLa Human Cell Line." data-caption="p300 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) at 1.7 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001" target="_self">NL001</a>) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunocytochemistry__Immunofluorescence_20772.jpg" data-id="1" data-application="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunocytochemistry__Immunofluorescence_20772.jpg" data-header="Human p300 Antibody, Catalog # AF3789" class="lazy" /> </div> </li> <li data-id="3" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Simple_Western_17009.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Simple_Western_17009.jpg" alt="Detection of Human p300 antibody by Simple WesternTM." title="Detection of Human p300 by Simple Western<sup>TM</sup>." data-caption="Simple Western lane view shows lysates of HeLa human cervical epithelial carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for p300 at approximately 308 kDa (as indicated) using 50 µg/mL of Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf109" target="_self">HAF109</a>). This experiment was conducted under reducing conditions and using the 66-440 kDa separation system." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Simple_Western_17009.jpg" data-id="2" data-application="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Simple_Western_17009.jpg" data-header="Human p300 Antibody, Catalog # AF3789" class="lazy" /> </div> </li> <li data-id="4" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunohistochemistry_20807.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunohistochemistry_20807.jpg" alt="p300 antibody in Human Colon Cancer Tissue by Immunohistochemistry (IHC-P)." title="p300 in Human Colon Cancer Tissue." data-caption="p300 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-visucyte-hrp-polymer_vc004" target="_self">VC004</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunohistochemistry_20807.jpg" data-id="3" data-application="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunohistochemistry_20807.jpg" data-header="Human p300 Antibody, Catalog # AF3789" class="lazy" /> </div> </li> </ul> </div> <div class="col-md-10 border rounded d-flex align-items-center justify-content-center product-image-lightbox"> <div class="text-center my-2" data-brand="rnd"> <img src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Western_Blot_5343.jpg" alt="Detection of Human p300 antibody by Western Blot." title="Detection of Human p300 by Western Blot." data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Western_Blot_5343.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Western_Blot_5343.jpg" data-caption="Western blot shows nuclear extracts of A431 human epithelial carcinoma cell line epidermoid carcinoma and HeLa human cervical epithelial carcinoma cell line cervical carcinoma cell lines. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf017" target="_self">HAF017</a>). A specific band was detected for p300 at approximately 300 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1." data-badges='' data-id="0" data-header="Human p300 Antibody, Catalog # AF3789" width="250" height="250" fetchpriority="high" as="image" class="search_result_thumbnail_image active" /> </div> </div> </div> </div> </div> <div class="col-xl-6 mt-2" id="orderdetails-wrapper" data-section="order_detail_block"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="AF3789"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-3 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart" class="atc-lines"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="AF3789" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">AF3789</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="AF3789-SP" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">AF3789-SP</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="promo-content alert alert-success" role="alert"> <p>Save on RUO reagents! 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" href="#preparation--storage"> Preparation & Storage</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#background"> Background</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#product-documents"> Product Documents</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#specific-notices"> Specific Notices</a> </li> </ul> </div> <div id="key_details" class="py-5 bt-pp-border-bottom" data-section="section-base--key-details"> <h3>Key Product Details</h3> <div class="mt-5 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Validated by</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Biological Validation </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Species Reactivity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <h4 class="d-block">Validated:</h4> <div class="d-block pb-2"> Human </div> <h4 class="d-block">Cited:</h4> <div class="d-block pb-2"> Mouse </div> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Applications</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <h4 class="d-block">Validated:</h4> <div class="d-block pb-2"> Chromatin Immunoprecipitation (ChIP), Immunocytochemistry, Immunohistochemistry, Simple Western, Western Blot </div> <h4 class="d-block">Cited:</h4> <div class="d-block pb-2"> Immunocytochemistry </div> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Label</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Unconjugated </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Antibody Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Polyclonal Goat IgG </div> </div> </div> <div class="container"> <div class="row product-data"> <div class="col-lg-6 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4><a href="/t/p300/antibodies">View all p300 Antibodies »</a></h4> </div> </div> </div> </div> <div class="border-top border-bottom recommended-products-section" id="recommendation-viewed" data-product_code="AF3789" data-type=viewed></div> <div id="product-specifications" class="bt-pp-border-bottom py-5" data-section="section-base--product-specifications"> <h3>Product Specifications</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Immunogen</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <EM>E. coli</EM>-derived recombinant human p300<br />His2283-His2414<br />Accession # Q09472 </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Specificity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Detects human p300 in Western blots. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Clonality</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Polyclonal </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Goat </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Isotype</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> IgG </div> </div> </div> </div> <div id="scientific-data" class="bt-pp-border-bottom py-5" data-anchor-label="Scientific Data" data-section="section-base--scientific-data"> <div> <h3>Scientific Data Images for Human p300 Antibody </h3> </div> <div class="product-data-wrapper mt-5" id="scientific-data-table" data-scientific-count="2"> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Western_Blot_5343.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Western_Blot_5343.jpg" alt="Detection of Human p300 antibody by Western Blot." title="Detection of Human p300 by Western Blot." data-caption="Western blot shows nuclear extracts of A431 human epithelial carcinoma cell line epidermoid carcinoma and HeLa human cervical epithelial carcinoma cell line cervical carcinoma cell lines. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf017" target="_self">HAF017</a>). A specific band was detected for p300 at approximately 300 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1." data-badges="" data-application="Western Blot" data-header="Human p300 Antibody, Catalog # AF3789" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Detection of Human p300 by Western Blot.</h4> Western blot shows nuclear extracts of A431 human epithelial carcinoma cell line epidermoid carcinoma and HeLa human cervical epithelial carcinoma cell line cervical carcinoma cell lines. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf017" target="_self">HAF017</a>). A specific band was detected for p300 at approximately 300 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Chromatin_Immunoprecipitation_11239.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Chromatin_Immunoprecipitation_11239.jpg" alt="Detection of p300-regulated Genes antibody by Chromatin Immunoprecipitation." title="Detection of p300-regulated Genes by Chromatin Immunoprecipitation." data-caption="Jurkat human acute T cell leukemia cell line treated with 50 ng/mL PMA and 200 ng/mL calcium ionomycin for 30 minutes was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. p300/DNA complexes were immunoprecipitated using 5 µg Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) or control antibody (Catalog # <a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/donkey-anti-goat-igg-biotinylated-antibody_baf109" target="_self">BAF109</a>). Immunocomplexes were captured using 50 µL of MagCellect Streptavidin Ferrofluid (Catalog # MAG999) and DNA was purified using chelating resin solution. The<em>fos</em>promoter was detected by standard PCR." data-badges="<span class="biological-validation"></span>" data-application="Chromatin Immunoprecipitation (ChIP)" data-header="Human p300 Antibody, Catalog # AF3789" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <div class="validation-badges-header-wrapper"> <a class="biological-validation mr-3 d-inline-flex mt-1" href="/reagents/antibodies/antibody-validation" target="_blank" title="Biological Validation"></a> </div> <h4 class="font-weight-bold">Detection of p300-regulated Genes by Chromatin Immunoprecipitation.</h4> Jurkat human acute T cell leukemia cell line treated with 50 ng/mL PMA and 200 ng/mL calcium ionomycin for 30 minutes was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. p300/DNA complexes were immunoprecipitated using 5 µg Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) or control antibody (Catalog # <a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/donkey-anti-goat-igg-biotinylated-antibody_baf109" target="_self">BAF109</a>). Immunocomplexes were captured using 50 µL of MagCellect Streptavidin Ferrofluid (Catalog # MAG999) and DNA was purified using chelating resin solution. The<em>fos</em>promoter was detected by standard PCR. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunocytochemistry__Immunofluorescence_20772.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunocytochemistry__Immunofluorescence_20772.jpg" alt="p300 antibody in HeLa Human Cell Line by Immunocytochemistry (ICC)." title="p300 in HeLa Human Cell Line." data-caption="p300 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) at 1.7 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001" target="_self">NL001</a>) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." data-badges="" data-application="Immunocytochemistry" data-header="Human p300 Antibody, Catalog # AF3789" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">p300 in HeLa Human Cell Line.</h4> p300 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) at 1.7 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001" target="_self">NL001</a>) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips. </div> </div> </div> <span class="product-data-wrapper table" id="more-scientific-data" style="display:none"> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Simple_Western_17009.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Simple_Western_17009.jpg" alt="Detection of Human p300 antibody by Simple WesternTM." title="Detection of Human p300 by Simple Western<sup>TM</sup>." data-caption="Simple Western lane view shows lysates of HeLa human cervical epithelial carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for p300 at approximately 308 kDa (as indicated) using 50 µg/mL of Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf109" target="_self">HAF109</a>). This experiment was conducted under reducing conditions and using the 66-440 kDa separation system." data-badges="" data-application="Simple Western" data-header="Human p300 Antibody, Catalog # AF3789" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Detection of Human p300 by Simple Western<sup>TM</sup>.</h4> Simple Western lane view shows lysates of HeLa human cervical epithelial carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for p300 at approximately 308 kDa (as indicated) using 50 µg/mL of Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf109" target="_self">HAF109</a>). This experiment was conducted under reducing conditions and using the 66-440 kDa separation system. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunohistochemistry_20807.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/p300_AF3789_Immunohistochemistry_20807.jpg" alt="p300 antibody in Human Colon Cancer Tissue by Immunohistochemistry (IHC-P)." title="p300 in Human Colon Cancer Tissue." data-caption="p300 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-visucyte-hrp-polymer_vc004" target="_self">VC004</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." data-badges="" data-application="Immunohistochemistry" data-header="Human p300 Antibody, Catalog # AF3789" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">p300 in Human Colon Cancer Tissue.</h4> p300 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Goat Anti-Human p300 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3789) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-visucyte-hrp-polymer_vc004" target="_self">VC004</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. </div> </div> </span> <div class="row"> <div class="col-md-2"> <a id="scientific-view-more" class="more"> View 2 more images </a> </div> </div> </div> </div> <div id="applications" class="py-5 bt-pp-border-bottom" data-anchor-label="Applications" data-section="section-antibody--applications"> <h3>Applications for Human p300 Antibody </h3> <div class="mt-5 py-2 container"> <div class="row"> <div class="col-lg-3 border font-weight-bold text-bg-dark py-2 align-top text-md-left text-white bg-dark-bt-blue d-none d-lg-block"> Application </div> <div class="col-lg-9 border align-top py-2 font-weight-bold text-white bg-dark-bt-blue d-none d-lg-block"> Recommended Usage </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Chromatin Immunoprecipitation (ChIP)</h4> </div> <div class="col-lg-9 border align-top py-2"> 5 µg/5 x 10<sup>6</sup> cells <br/>Sample: PMA and calcium ionomycin treated Jurkat human acute T cell leukemia cell line chromatin, <em>fos</em> promoter detected by standard PCR. </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Immunocytochemistry</h4> </div> <div class="col-lg-9 border align-top py-2"> 1-15 µg/mL <br/>Sample: Immersion fixed HeLa human cervical epithelial carcinoma cell line </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Immunohistochemistry</h4> </div> <div class="col-lg-9 border align-top py-2"> 5-25 µg/mL <br/>Sample: Immersion fixed paraffin-embedded sections of human colon cancer tissue </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Simple Western</h4> </div> <div class="col-lg-9 border align-top py-2"> 50 µg/mL <br/>Sample: HeLa human cervical epithelial carcinoma cell line </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Western Blot</h4> </div> <div class="col-lg-9 border align-top py-2"> 1 µg/mL <br/>Sample: A431 human epithelial carcinoma cell line epidermoid carcinoma and HeLa human cervical epithelial carcinoma cell line cervical carcinoma cell lines </div> </div> </div> </div> <div id="preparation--storage" class="bt-pp-border-bottom py-5" data-section="section-base--preparation-storage"> <h3>Formulation, Preparation, and Storage</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Purification</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Antigen Affinity-purified </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Reconstitution</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <div class="atc-container"> <div class="commerce-atc-reconstitution atc-block" data-type="reconstitution" data-blockid="ReconstitutionCart"> <div class="commerce-atc-reconstitution__instructions"> Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration. </div> <p class="atc-modal"></p> <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode=""> <div class="commerce-atc-reconstitution-header atc-header col-four row border-top pt-2 m-0"> <div class="commerce-atc-catnum atc-head col-md-6 font-weight-bold p-0">Reconstitution Buffer Available:</div> <div class="commerce-atc-price atc-head col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-md-3 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ReconstitutionCart" class="atc-lines"> <div class="commerce-atc-reconstitution-line productline col-four row py-2 m-0" data-catalog="RB01"> <div class="commerce-atc-title col-md-6 p-0"> <a href="">RB01: </a> </div> <div class="commerce-atc-price col-md-3"> </div> <div class="commerce-atc-quantity col-md-3 text-right p-0"> </div> </div> </div> <div class="atc-control ReconstitutionCart-control text-right mt-2"> <input type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc col-xs-4"/> </div> </div> </form> </div> </div> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Formulation</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Shipping</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Stability & Storage</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>6 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL> </div> </div> </div> </div> <div id="background" class="py-5 bt-pp-border-bottom" data-section="section-base--background-info"> <h3>Background: p300</h3> <article class="product-data-wrapper"> <p>The E1A-binding protein p300 is a histone acetyltransferase that also acts to acetylate other proteins, such as p53. p300 acts as a transcriptional coactivator that can serve as an adaptor molecule to bridge to transcriptional regulators. In addition, p300 binds to PCNA and may participate in chromatin remodeling.</p> </article> <div id="background_wrapper" class="px-3 mt-2"> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Long Name</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> E1A-binding Protein p300 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Alternate Names</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> EP300 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Entrez Gene IDs</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.ncbi.nlm.nih.gov/gene?term=2033" class="a___link-external" target="_blank" rel="nofollow">2033</a> (Human); <a href="https://www.ncbi.nlm.nih.gov/gene?term=328572" class="a___link-external" target="_blank" rel="nofollow">328572</a> (Mouse) </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Gene Symbol</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> EP300 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>UniProt</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.uniprot.org/uniprot/?query=Q09472" class="a___link-external" target="_blank" rel="nofollow">Q09472</a> </div> </div> </div> <h4 class="mt-3">Additional p300 Products</h4> <ul class="list-unstyled"> <li class="py-1"><a href="/t/p300" data-product="p300">All Products for p300 </a></li> <li class="py-1"><a href="/t/p300/elisa-kits" data-application="p300 ELISA Kits">p300 ELISA Kits </a></li> <li class="py-1"><a href="/t/p300/antibodies" data-application="p300 Primary Antibodies">p300 Primary Antibodies </a></li> <li class="py-1"><a href="/t/p300/proteins-enzymes" data-application="p300 Proteins and Enzymes">p300 Proteins and Enzymes </a></li> </ul> </div> <div id="product-documents" data-section="section-base--product-documents"> <div id="accordion" class="border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3"> Product Documents for Human p300 Antibody </h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#accordion"> <div class="card-body"> <div class="row mb-2"> <div class="col-md-6"> <a href="https://resources.rndsystems.com/pdfs/datasheets/af3789.pdf" class="datasheet_link" target="_blank" rel="nofollow">Download Product Datasheets</a> </div> </div> </div> </div> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#accordion"> <div class="card-body"> <form novalidate="novalidate" data-drupal-selector="product-coa-form" action="#coa-form" method="post" id="product-coa-form" accept-charset="UTF-8"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please enter a lot number in the search box below.</p> <p><strong>Note:</strong> Certificate of Analysis not available for kit components.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form novalidate="novalidate" 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value="cs-cz">Czech</option> <option value="da-dk">Danish</option> <option value="nl-nl">Dutch</option> <option value="en-us">English</option> <option value="de-de">German</option> <option value="fr-fr">French</option> <option value="hu-hu">Hungarian</option> <option value="it-it">Italian</option> <option value="nb-no">Norwegian</option> <option value="pl-pl">Polish</option> <option value="es-es">Spanish</option> <option value="sv-se">Swedish</option> </select> <span class="sds-pdf-result datasheet-loading"></span> </div> <div class="col my-3 pt-1 text-center text-lg-left"> <a class="sds-link datasheet_link datasheet-button-link text-wrap text-bt-blue" > Download SDS </a> </div> </div> </div> </div> </div> </div> <div id="specific-notices" class="py-5" data-section="section-base--specific-notices"> <h3>Product Specific Notices for Human p300 Antibody </h3> <p></p><p>For research use only</p> </div> </div> <div class="tab-pane fade" id="citations_reviews" role="tabpanel" 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Human p300 Antibody (AF3789) by R&D Systems, Part of Bio-Techne