CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-disabled skin-theme-clientpref-day vector-toc-available" lang="sh-Latn" dir="ltr"> <head> <meta charset="UTF-8"> <title>Pegilirani interferon alfa-2b – Wikipedija/Википедија</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-disabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )shwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":[",\t.",".\t,"],"wgDigitTransformTable":["",""], "wgDefaultDateFormat":"dmy sh-latn","wgMonthNames":["","januar","februar","mart","april","maj","juni","juli","august","septembar","oktobar","novembar","decembar"],"wgRequestId":"2dd6a35f-1981-4c7a-a3ee-4b78042820b6","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Pegilirani_interferon_alfa-2b","wgTitle":"Pegilirani interferon alfa-2b","wgCurRevisionId":41866620,"wgRevisionId":41866620,"wgArticleId":1236850,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["Svi članci s mrtvim eksternim linkovima","Članci lekova bez strukture","Webarchive template wayback links","Interleukini","Antivirotici","Imunostimulanti","Depresogeni"],"wgPageViewLanguage":"sh-latn","wgPageContentLanguage":"sh-latn","wgPageContentModel":"wikitext","wgRelevantPageName":"Pegilirani_interferon_alfa-2b","wgRelevantArticleId":1236850,"wgTempUserName":null,"wgUserVariant":"sh-latn","wgIsProbablyEditable":true ,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"sh","pageLanguageDir":"ltr","pageVariantFallbacks":"sh-latn"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":true,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":8000,"wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q7160789","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false, "wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false,"wgSiteNoticeId":"2.8"};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready","ext.dismissableSiteNotice.styles":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.charinsert","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap", "ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking","ext.dismissableSiteNotice"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"});mw.user.options.set({"language":"sh-latn"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=sh-latn&modules=ext.cite.styles%7Cext.dismissableSiteNotice.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=sh-latn&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=sh-latn&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Pegilirani interferon alfa-2b – Wikipedija/Википедија"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//sh.m.wikipedia.org/wiki/Pegilirani_interferon_alfa-2b"> <link rel="alternate" type="application/x-wiki" title="Uredi" href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedija (sh)"> <link rel="EditURI" type="application/rsd+xml" href="//sh.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://sh.wikipedia.org/wiki/Pegilirani_interferon_alfa-2b"> <link rel="alternate" hreflang="sh" href="https://sh.wikipedia.org/wiki/Pegilirani_interferon_alfa-2b"> <link rel="alternate" hreflang="sh-Cyrl" href="https://sh.wikipedia.org/w/index.php?title=Pegilirani_interferon_alfa-2b&variant=sh-cyrl"> <link rel="alternate" hreflang="sh-Latn" href="https://sh.wikipedia.org/w/index.php?title=Pegilirani_interferon_alfa-2b&variant=sh-latn"> <link rel="alternate" hreflang="x-default" href="https://sh.wikipedia.org/wiki/Pegilirani_interferon_alfa-2b"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.sh"> <link rel="alternate" type="application/atom+xml" title="Wikipedija Atom fid" href="/w/index.php?title=Posebno:Nedavne_izmjene&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Pegilirani_interferon_alfa-2b rootpage-Pegilirani_interferon_alfa-2b skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Prijeđi na sadržaj</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Sajt"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Glavni meni" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Glavni meni</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Glavni meni</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">sakrij</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Navigacija </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Glavna_stranica" title="Posjetite glavnu stranicu [z]" accesskey="z"><span>Glavna stranica</span></a></li><li id="n-featuredcontent" class="mw-list-item"><a href="/wiki/Wikipedija:Istaknuti_%C4%8Dlanci" title="Pronađite najkvalitetnije članke"><span>Istaknuti članci</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Posebno:Nedavne_izmjene" title="Prelistajte nove izmjene [r]" accesskey="r"><span>Nedavne izmjene</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Posebno:Slu%C4%8Dajna_stranica" title="Otvorite slučajan članak [x]" accesskey="x"><span>Nasumičan članak</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Interakcija </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Pomo%C4%87:Sadr%C5%BEaj" title="Saznajte više o upotrebi i uređivanju"><span>Pomoć</span></a></li><li id="n-sidebar-village-pump" class="mw-list-item"><a href="/wiki/Wikipedija:Pijaca"><span>Pijaca</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedija:Portal_zajednice" title="Pronađite aktualne zadatke i akcije"><span>Radionica</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Wikipedija:Novosti" title="Pogledajte tekuće događaje i aktualnosti"><span>Novosti</span></a></li><li id="n-forum" class="mw-list-item"><a href="https://forum.movement-strategy.org/c/general/meduprojektniforum/40" rel="nofollow"><span>Međuprojektni forum</span></a></li><li id="n-discord" class="mw-list-item"><a href="https://discord.gg/khcKdUUxYY" rel="nofollow"><span>Discord</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Glavna_stranica" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedija" src="/static/images/mobile/copyright/wikipedia-wordmark-sh-latn.svg" style="width: 7.5em; height: 2em;"> <img class="mw-logo-tagline" alt="" src="/static/images/mobile/copyright/wikipedia-tagline-sh-latn.svg" width="120" height="18" style="width: 7.5em; height: 1.125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Posebno:Tra%C5%BEi" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Pretražite Wikipediju [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Pretraga</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Pretražite Wikipediju" aria-label="Pretražite Wikipediju" autocapitalize="sentences" title="Pretražite Wikipediju [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Posebno:Traži"> </div> <button class="cdx-button cdx-search-input__end-button">Pretraži</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Osobne alatke"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Izgled"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Izgled" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Izgled</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_sh.wikipedia.org&uselang=sh" class=""><span>Donacije</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Posebno:Stvori_ra%C4%8Dun&returnto=Pegilirani+interferon+alfa-2b" title="Preporučujemo da izradite račun i prijavite se, ali to nije obavezno" class=""><span>Izradi račun</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Posebno:Korisni%C4%8Dka_prijava&returnto=Pegilirani+interferon+alfa-2b" title="Preporučujemo da se prijavite, ali to nije obavezno [o]" accesskey="o" class=""><span>Prijavi me</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out user-links-collapsible-item" title="Više mogućnosti" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Osobne alatke" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Osobne alatke</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Korisnički meni" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_sh.wikipedia.org&uselang=sh"><span>Donacije</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Posebno:Stvori_ra%C4%8Dun&returnto=Pegilirani+interferon+alfa-2b" title="Preporučujemo da izradite račun i prijavite se, ali to nije obavezno"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Izradi račun</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Posebno:Korisni%C4%8Dka_prijava&returnto=Pegilirani+interferon+alfa-2b" title="Preporučujemo da se prijavite, ali to nije obavezno [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Prijavi me</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"><div id="mw-dismissablenotice-anonplace"></div><script>(function(){var node=document.getElementById("mw-dismissablenotice-anonplace");if(node){node.outerHTML="\u003Cdiv class=\"mw-dismissable-notice\"\u003E\u003Cdiv class=\"mw-dismissable-notice-close\"\u003E[\u003Ca tabindex=\"0\" role=\"button\"\u003Ezatvori\u003C/a\u003E]\u003C/div\u003E\u003Cdiv class=\"mw-dismissable-notice-body\"\u003E\u003C!-- CentralNotice --\u003E\u003Cdiv id=\"localNotice\" data-nosnippet=\"\"\u003E\u003Cdiv class=\"anonnotice\" lang=\"sh\" dir=\"ltr\"\u003E\u003Ctable class=\"plainlinks fmbox fmbox-system\" style=\"clear: both; margin: 0.2em 0; border: 1px solid #aaa; background: #f9f9f9; width: 100%; background: #f9f9f9; border:1px solid black; padding: 2px 5px\"\u003E\n\u003Ctbody\u003E\u003Ctr\u003E\t\n\u003Ctd class=\"mbox-image\"\u003E\n \u003Cspan typeof=\"mw:File\"\u003E\u003Ca href=\"/wiki/Wikipedija:Mjesec_Azije/2024\" title=\"Wikipedija:Mjesec Azije/2024\"\u003E\u003Cimg src=\"//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/WAM_logo_without_text.svg/25px-WAM_logo_without_text.svg.png\" decoding=\"async\" width=\"25\" height=\"27\" class=\"mw-file-element\" srcset=\"//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/WAM_logo_without_text.svg/38px-WAM_logo_without_text.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/WAM_logo_without_text.svg/50px-WAM_logo_without_text.svg.png 2x\" data-file-width=\"800\" data-file-height=\"859\" /\u003E\u003C/a\u003E\u003C/span\u003E\u003C/td\u003E\n\u003Ctd class=\"mbox-text\" style=\"\"\u003E Od 1. do 30. novembra održava se uređivački maraton \u003Ca href=\"/wiki/Wikipedija:Mjesec_Azije/2024\" title=\"Wikipedija:Mjesec Azije/2024\"\u003EMjesec Azije\u003C/a\u003E. \u003C/td\u003E\n\u003C/tr\u003E\n\u003C/tbody\u003E\u003C/table\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Sajt"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Sadržaj" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Sadržaj</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">sakrij</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Početak</div> </a> </li> <li id="toc-Mehanizam_Akcije" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mehanizam_Akcije"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Mehanizam Akcije</span> </div> </a> <ul id="toc-Mehanizam_Akcije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Genetički_faktori_koji_utiču_na_respons_tretmana" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Genetički_faktori_koji_utiču_na_respons_tretmana"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Genetički faktori koji utiču na respons tretmana</span> </div> </a> <ul id="toc-Genetički_faktori_koji_utiču_na_respons_tretmana-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prikaži/sakrij sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prikaži/sakrij sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading" lang="sh-Latn" dir="ltr"><span class="mw-page-title-main">Pegilirani interferon alfa-2b</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prijedi na druge jezične varijante članka. Dostupno je na 12 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-12" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">12 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A8%D9%8A%D8%BA%D9%86%D8%AA%D9%8A%D8%B1%D9%81%D9%8A%D8%B1%D9%88%D9%86_%E2%80%93_%D8%A3%D9%84%D9%81%D8%A7_%E2%80%93_2%D8%A8" title="بيغنتيرفيرون – ألفا – 2ب — Arapski" lang="ar" hreflang="ar" data-title="بيغنتيرفيرون – ألفا – 2ب" data-language-autonym="العربية" data-language-local-name="Arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b — Engleski" lang="en" hreflang="en" data-title="Peginterferon alfa-2b" data-language-autonym="English" data-language-local-name="Engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Peginterfer%C3%B3n_alfa-2b" title="Peginterferón alfa-2b — Španski" lang="es" hreflang="es" data-title="Peginterferón alfa-2b" data-language-autonym="Español" data-language-local-name="Španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Peginterf%C3%A9ron_alfa-2b" title="Peginterféron alfa-2b — Francuski" lang="fr" hreflang="fr" data-title="Peginterféron alfa-2b" data-language-autonym="Français" data-language-local-name="Francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%8A%D5%A5%D5%A3%D5%AB%D5%AC%D5%A1%D6%81%D5%BE%D5%A1%D5%AE_%D5%AB%D5%B6%D5%BF%D5%A5%D6%80%D6%86%D5%A5%D6%80%D5%B8%D5%B6_%D5%A1%D5%AC%D6%86%D5%A1-2b" title="Պեգիլացված ինտերֆերոն ալֆա-2b — Jermenski" lang="hy" hreflang="hy" data-title="Պեգիլացված ինտերֆերոն ալֆա-2b" data-language-autonym="Հայերեն" data-language-local-name="Jermenski" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b — Indonezijski" lang="id" hreflang="id" data-title="Peginterferon alfa-2b" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonezijski" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b — Malajski" lang="ms" hreflang="ms" data-title="Peginterferon alfa-2b" data-language-autonym="Bahasa Melayu" data-language-local-name="Malajski" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AA%E0%AD%87%E0%AC%9C%E0%AC%BF%E0%AC%A3%E0%AD%8D%E0%AC%9F%E0%AC%B0%E0%AC%AB%E0%AD%87%E0%AC%B0%E0%AC%A8_%E0%AC%86%E0%AC%B2%E0%AC%AB%E0%AC%BE-%E0%AD%A8%E0%AC%AC%E0%AC%BF" title="ପେଜିଣ୍ଟରଫେରନ ଆଲଫା-୨ବି — Orijski" lang="or" hreflang="or" data-title="ପେଜିଣ୍ଟରଫେରନ ଆଲଫା-୨ବି" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Orijski" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b — Poljski" lang="pl" hreflang="pl" data-title="Peginterferon alfa-2b" data-language-autonym="Polski" data-language-local-name="Poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Pegilirani_interferon_alfa-2b" title="Pegilirani interferon alfa-2b — Srpski" lang="sr" hreflang="sr" data-title="Pegilirani interferon alfa-2b" data-language-autonym="Српски / srpski" data-language-local-name="Srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9F%D0%B5%D0%B3%D1%96%D0%BB%D1%8C%D0%BE%D0%B2%D0%B0%D0%BD%D0%B8%D0%B9_%D1%96%D0%BD%D1%82%D0%B5%D1%80%D1%84%D0%B5%D1%80%D0%BE%D0%BD_%D0%B0%D0%BB%D1%8C%D1%84%D0%B0-2b" title="Пегільований інтерферон альфа-2b — Ukrajinski" lang="uk" hreflang="uk" data-title="Пегільований інтерферон альфа-2b" data-language-autonym="Українська" data-language-local-name="Ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b — Vijetnamski" lang="vi" hreflang="vi" data-title="Peginterferon alfa-2b" data-language-autonym="Tiếng Việt" data-language-local-name="Vijetnamski" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q7160789#sitelinks-wikipedia" title="Uredi međujezične poveznice" class="wbc-editpage">Uredi veze</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Pegilirani_interferon_alfa-2b" title="Vidi stranicu sadržaja [c]" accesskey="c"><span>Stranica</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Razgovor:Pegilirani_interferon_alfa-2b" rel="discussion" title="Razgovarajte o sadržini ove stranice [t]" accesskey="t"><span>Razgovor</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Promijeni jezičnu varijantu" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Latinica</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-varlang-0" class="selected ca-variants-sh-Latn mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&variant=sh-latn" lang="sh-Latn" hreflang="sh-Latn"><span>Latinica</span></a></li><li id="ca-varlang-1" class="ca-variants-sh-Cyrl mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&variant=sh-cyrl" lang="sh-Cyrl" hreflang="sh-Cyrl"><span>Ћирилица</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Teme"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Pegilirani_interferon_alfa-2b"><span>Prikaži</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi kod</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=history" title="Pogledajte prethodne verzije ove stranice [h]" accesskey="h"><span>Historija</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Pomagala"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Alatke" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Alatke</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Alati</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">sakrij</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Više mogućnosti" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Radnje </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Pegilirani_interferon_alfa-2b"><span>Prikaži</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi kod</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=history"><span>Historija</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Opšte </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Posebno:%C5%A0to_vodi_ovdje/Pegilirani_interferon_alfa-2b" title="Pogledajte listu svih stranica koje vode ovamo [j]" accesskey="j"><span>Šta vodi ovamo</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:Povezane_izmjene/Pegilirani_interferon_alfa-2b" rel="nofollow" title="Prelistajte nedavne izmjene stranica koje su povezane s ovom [k]" accesskey="k"><span>Povezane izmjene</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:Posebne_stranice" title="Pregledajte listu svih posebnih stranica [q]" accesskey="q"><span>Posebne stranice</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&oldid=41866620" title="Nabavite trajnu vezu do ove verzije stranice"><span>Trajna veza</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=info" title="Pronađite više informacija o ovoj stranici"><span>Podaci o stranici</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Posebno:Citiraj&page=Pegilirani_interferon_alfa-2b&id=41866620&wpFormIdentifier=titleform" title="Saznajte kako da citirate ovu stranicu"><span>Citiraj stranicu</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Posebno:Skra%C4%87iva%C4%8D_adresa&url=https%3A%2F%2Fsh.wikipedia.org%2Fwiki%2FPegilirani_interferon_alfa-2b"><span>Skrati URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Posebno:QrCode&url=https%3A%2F%2Fsh.wikipedia.org%2Fwiki%2FPegilirani_interferon_alfa-2b"><span>Preuzmi QR kod</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Štampanje/izvoz </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Posebno:Kolekcija&bookcmd=book_creator&referer=Pegilirani+interferon+alfa-2b"><span>Napravi knjigu</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Posebno:DownloadAsPdf&page=Pegilirani_interferon_alfa-2b&action=show-download-screen"><span>Preuzmi kao PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&printable=yes" title="Odštampajte ovu stranicu [p]" accesskey="p"><span>Odštampaj</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Na drugim projektima </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q7160789" title="Pogledajte povezanu stavku u skladištu podataka [g]" accesskey="g"><span>Stavka na Wikipodacima</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Pomagala"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Izgled"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Izgled</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">sakrij</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Izvor: Wikipedija</div> </div> <div id="contentSub" lang="sh-Latn" dir="ltr"><div id="mw-content-subtitle" lang="sh-Latn" dir="ltr"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sh-Latn" dir="ltr"><table class="infobox" style="text-align: left; font-size: 88%; width: 22em; line-height: 1.5em"> <caption style="font-size: 125%; font-weight: bold">Pegilirani interferon alfa-2b </caption> <tbody><tr> <th colspan="2" style="text-align: center; background-color: #ddd">(<a href="/wiki/IUPAC" class="mw-redirect" title="IUPAC">IUPAC</a>) ime </th></tr> <tr> <td colspan="2" style="text-align: center; vertical-align: top; background-color: #eee"><span style="font-size:11px">PEGylated human interferon alpha 2b</span> </td></tr> <tr> <th colspan="2" style="background-color: #ddd; text-align: center"><b>Klinički podaci</b> </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd"><b>Identifikatori</b> </th></tr> <tr> <td style="background-color: #def"><a href="/wiki/CAS_registarski_broj" title="CAS registarski broj">CAS broj</a> </td> <td style="background-color: #eee"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?term=99210-65-8&rn=1">99210-65-8</a></span> </td></tr> <tr> <td style="background-color: #def; width: 90px"><a href="/wiki/Anatomsko_Terapeutsko_Hemijsko_Klasifikacioni_Sistem" class="mw-redirect" title="Anatomsko Terapeutsko Hemijsko Klasifikacioni Sistem">ATC kod</a> </td> <td style="background-color: #eee"><a href="/wiki/ATC_kod_L03" title="ATC kod L03">L03</a><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=L03AB10">AB10</a></span> </td></tr> <tr> <td style="background-color: #def"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a> </td> <td style="background-color: #eee"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.drugbank.ca/cgi-bin/show_drug.cgi?CARD=BTD00048">BTD00048</a></span> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Hemijski podaci </th></tr> <tr> <td style="background-color: #def"><a href="/wiki/Hemijska_formula" class="mw-redirect" title="Hemijska formula">Formula</a> </td> <td style="background-color: #eee"><a href="/wiki/Ugljenik" title="Ugljenik"><span style="color: rgb(000,000,000); font-weight: bold;">C</span></a><sub>860</sub><a href="/wiki/Vodonik" class="mw-redirect" title="Vodonik"><span style="color: rgb(77,77,77); font-weight: bold;">H</span></a><sub>1353</sub><a href="/wiki/Azot" class="mw-redirect" title="Azot"><span style="color: rgb(0,0,128); font-weight: bold;">N</span></a><sub>229</sub><a href="/wiki/Kiseonik" title="Kiseonik"><span style="color: rgb(116,35,35); font-weight: bold;">O</span></a><sub>255</sub><a href="/wiki/Sumpor" title="Sumpor"><span style="color: rgb(114,97,31); font-weight: bold;">S</span></a><sub>9</sub><sup> </sup> </td></tr> <tr> <td style="background-color: #def"><a href="/wiki/Molarna_masa" title="Molarna masa">Mol. masa</a> </td> <td style="background-color: #eee">19269.1 g/mol </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd"><a href="/wiki/(L)ADME(R)_sistem" class="mw-redirect" title="(L)ADME(R) sistem">Farmakokinetički</a> podaci </th></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Poluvreme_eliminacije" title="Poluvreme eliminacije">Poluvreme eliminacije</a> </td> <td style="background-color: #eee">22-60 sata <sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd"><b>Farmakoinformacioni podaci</b> </th></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Trudno%C4%87a" title="Trudnoća">Trudnoća</a> </td> <td style="background-color: #eee">? </td></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Regulacija_terapeutskih_dobara" title="Regulacija terapeutskih dobara">Pravni status</a> </td> <td style="background-color: #eee"> </td></tr> </tbody></table> <p><b><a href="/w/index.php?title=PEGilacija&action=edit&redlink=1" class="new" title="PEGilacija (stranica ne postoji)">Pegilirani</a> <a href="/wiki/Interferon" title="Interferon">interferon</a> alfa-2b</b> za tretman <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitisa C</a> je razvio Schering-Plough. Prodajno ime je <b>Peg Intron</b>. Odobren je januara <a href="/wiki/2001" title="2001">2001</a>. </p><p>PEG-interferon alfa je <a href="/w/index.php?title=Pegilirani&action=edit&redlink=1" class="new" title="Pegilirani (stranica ne postoji)">pegilirani</a> <a href="/wiki/Interferon" title="Interferon">interferon</a> koji se sastoji od 165 <a href="/wiki/Aminokiselina" title="Aminokiselina">aminokiselina</a>. <a href="/wiki/Polietilen_glikol" title="Polietilen glikol">PEG</a> (<a href="/wiki/Polietilen_glikol" title="Polietilen glikol">polietilen glikol</a>) zaštićuje molekul od proteolitičkog razlaganja i produžava <a href="/w/index.php?title=Biolo%C5%A1ki_polu%C5%BEivot&action=edit&redlink=1" class="new" title="Biološki poluživot (stranica ne postoji)">biološki poluživot</a> <a href="/wiki/Interferon" title="Interferon">interferon</a> <a href="/w/index.php?title=Rotein&action=edit&redlink=1" class="new" title="Rotein (stranica ne postoji)">roteina</a>. Dok se PEG-interferon alfa-2b obično koristi kao tretman za <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a>, bilo je pokazano da potencijalno može biti efikasan u tretmanu malignog <a href="/wiki/Melanom" title="Melanom">melanoma</a>. Takođe se koristi kod bolesnika sa <a href="/w/index.php?title=Neurofibromatoza&action=edit&redlink=1" class="new" title="Neurofibromatoza (stranica ne postoji)">neurofibromatozom</a> za umanjenje <a href="/w/index.php?title=Neurofibrom&action=edit&redlink=1" class="new" title="Neurofibrom (stranica ne postoji)">neurofibroma</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Mehanizam_Akcije">Mehanizam Akcije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&veaction=edit&section=1" title="Uredi odjeljak Mehanizam Akcije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit&section=1" title="Uredi kôd odjeljka Mehanizam Akcije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Jedan od glavnih mehanizama dejstva koji PEG-interferona alfa-2b koristi je <a href="/wiki/JAK-STAT_signalni_put" title="JAK-STAT signalni put">JAK-STAT</a> put signalizacije. Osnovni mehanizam je da se PEG-interferon alfa-2b vezuje za svoje receptore, interferon-alfa receptor 1 i 2 (IFNAR1/2). Nakon vezivanja liganda, <a href="/w/index.php?title=Tyk2&action=edit&redlink=1" class="new" title="Tyk2 (stranica ne postoji)">Tyk2</a> <a href="/wiki/Protein" title="Protein">protein</a> koji je povezan sa <a href="/w/index.php?title=IFNAR1&action=edit&redlink=1" class="new" title="IFNAR1 (stranica ne postoji)">IFNAR1</a> podleže <a href="/wiki/Fosforilacija" title="Fosforilacija">fosforilaciji</a> što dovodi do fosforilacije <a href="/w/index.php?title=Jak1&action=edit&redlink=1" class="new" title="Jak1 (stranica ne postoji)">Jak1</a> koji je asociran sa <a href="/w/index.php?title=IFNAR2&action=edit&redlink=1" class="new" title="IFNAR2 (stranica ne postoji)">IFNAR2</a>. Ove kinaze nastavljaju prenos signala putem fosforilacije prenosioca signala i aktivatora transkripcije (<a href="/w/index.php?title=STAT&action=edit&redlink=1" class="new" title="STAT (stranica ne postoji)">STAT</a>) 1 i 2. Fosforilisani <a href="/w/index.php?title=STAT&action=edit&redlink=1" class="new" title="STAT (stranica ne postoji)">STAT</a> se disocira od receptor heterodimera i formira interferon <a href="/wiki/Transkripcioni_faktor" title="Transkripcioni faktor">transkripcioni faktor</a> sa <a href="/w/index.php?title=P48&action=edit&redlink=1" class="new" title="P48 (stranica ne postoji)">p48</a> i <a href="/w/index.php?title=IRF9&action=edit&redlink=1" class="new" title="IRF9 (stranica ne postoji)">IRF9</a>, čime se formira interferon stimulišući transkripcioni faktor-3 (<a href="/w/index.php?title=ISGF3&action=edit&redlink=1" class="new" title="ISGF3 (stranica ne postoji)">ISGF3</a>). Ovaj transkripcioni faktor se translocira u <a href="/wiki/Nukleus" class="mw-redirect" title="Nukleus">nukleus</a> gde on transkribuje nekoliko gena sa ulogom u: kontroli ćelijskog ciklusa, ćelijskom diferencijacijom, <a href="/wiki/Apoptoza" title="Apoptoza">apoptozom</a>, i imunim odgovorom.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>PEG-interferon alfa-2b dejstvuje kao multifunkcionalni imunoregulatorni citokin putem transkribovanja nekoliko gena, uključujući <a href="/wiki/Interleukin_4" title="Interleukin 4">interleukin 4</a> (IL4). Ovoj citokin je odgovoran za induciranje <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije">T pomoćnih ćelija</a> da postanu tip 2 pomoćne <a href="/w/index.php?title=T_%C4%87elije&action=edit&redlink=1" class="new" title="T ćelije (stranica ne postoji)">T ćelije</a>. To ultimativno rezultuje u stimulaciji B ćelija da se proliferiraju i povećaju njihovu produkciju antitela. Ovime se omogućava imuni odgovor, jer <a href="/w/index.php?title=B_%C4%87elije&action=edit&redlink=1" class="new" title="B ćelije (stranica ne postoji)">B ćelije</a> učestvuju u predaju signala imunskom sistema da je strani antigen prisutan.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Još jedan značajni mehanizam <a href="/wiki/Interferon_tip_I#IFN-α" title="Interferon tip I">tip I interferona alfa</a> (IFNα) je da on stimulate <a href="/wiki/Apoptoza" title="Apoptoza">apoptozu</a> malignih ćelijskih linija. Prethodna istraživanja su pokazala da <a href="/wiki/Interferon_tip_I#IFN-α" title="Interferon tip I">IFNα</a> može da uzrokuje arest ćelijskog ciklusa kod U266, Daudi, i Rhek-1 ćelijskih linija.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Naknadne studije su istražile da li <a href="/wiki/Kaspaza" title="Kaspaza">kaspaze</a> učestvuju u apoptozi opisanoj u prethodnoj studiji, i pokušale su da ustanove ulogu oslobađanja <a href="/wiki/Mitohondrija" class="mw-redirect" title="Mitohondrija">mitohondrijalnog</a> <a href="/w/index.php?title=Citohrom_c&action=edit&redlink=1" class="new" title="Citohrom c (stranica ne postoji)">citohroma c</a>. Potvrđeno je da dolazi do rascepa putem kaspaze-3, -8, i -9. Sve tri od ovih <a href="/w/index.php?title=Cistein_proteaza&action=edit&redlink=1" class="new" title="Cistein proteaza (stranica ne postoji)">cistein proteaza</a> igraju važnu ulogu u inicijaciji i aktivaciji apoptotičke kaskade. Osim toga, bilo je pokazano da IFNα indukuje gubitak potencijala mitohondrijalne membrane, što rezultuje u oslobađanju <a href="/w/index.php?title=Citohroma_c&action=edit&redlink=1" class="new" title="Citohroma c (stranica ne postoji)">citohroma c</a> iz <a href="/wiki/Mitohondrija" class="mw-redirect" title="Mitohondrija">mitohondrija</a>. Dalja istraživanja su u toku da bi se utvrdili uzvodni aktivatori apoptotičkog puta koje IFNα inducira.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Genetički_faktori_koji_utiču_na_respons_tretmana"><span id="Geneti.C4.8Dki_faktori_koji_uti.C4.8Du_na_respons_tretmana"></span>Genetički faktori koji utiču na respons tretmana</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&veaction=edit&section=2" title="Uredi odjeljak Genetički faktori koji utiču na respons tretmana" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit&section=2" title="Uredi kôd odjeljka Genetički faktori koji utiču na respons tretmana"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Za genotip 1 <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitisa C</a> tretiran sa <a href="/wiki/Pegilirani_interferon_alfa-2a" title="Pegilirani interferon alfa-2a">pegiliranim interferonom alfa-2a</a> ili pegiliranim interferonom-alfa 2b (brend Pegasys ili PEG-Intron) u kombinaciji sa <a href="/wiki/Ribavirin" title="Ribavirin">ribavirinom</a>, bilo je pokazano da su genetički polimorfizmi blizo ljudskog <a href="/w/index.php?title=IL28&action=edit&redlink=1" class="new" title="IL28 (stranica ne postoji)">IL28</a>B gena, koji kodira interferon lambda 3, asocirani sa značajnim razlikama u responsu na tretman. Ovaj nalaz, originalno objavljen u <a href="/wiki/Nature" title="Nature">Nature</a> <sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>, je ukazao da genotip 1 <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a> pacijenta koji nose određene genetičke varijante alela blizo <a href="/w/index.php?title=IL28&action=edit&redlink=1" class="new" title="IL28 (stranica ne postoji)">IL28</a>B gene imaju veće šanse da postignu održiv virološki odziv nakon tretmana nego drugi. Kasniji izveštaj is istog žurnala<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> je demonstrirao da su iste genetičke varijante takođe povezane sa prirodnim čišćenjem genotip 1 <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a> virusa. </p> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&veaction=edit&section=3" title="Uredi odjeljak Literatura" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit&section=3" title="Uredi kôd odjeljka Literatura"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r41556849">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="http://www.fda.gov/downloads/Drugs/DrugSafety/UCM133677.pdf">„DrugSafety”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=DrugSafety&rft.atitle=&rft_id=http%3A%2F%2Fwww.fda.gov%2Fdownloads%2FDrugs%2FDrugSafety%2FUCM133677.pdf&rfr_id=info:sid/en.wikipedia.org:Pegilirani_interferon_alfa-2b"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/ct2/show/NCT00049530?term=PEG+interferon+alpha+2b+melanoma&rank=1">„PEG-Interferon Alfa-2b in Treating Patients With Stage IV Melanoma - Full Text View - ClinicalTrials.gov”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=PEG-Interferon+Alfa-2b+in+Treating+Patients+With+Stage+IV+Melanoma+-+Full+Text+View+-+ClinicalTrials.gov&rft.atitle=&rft_id=http%3A%2F%2Fwww.clinicaltrials.gov%2Fct2%2Fshow%2FNCT00049530%3Fterm%3DPEG%2Binterferon%2Balpha%2B2b%2Bmelanoma%26rank%3D1&rfr_id=info:sid/en.wikipedia.org:Pegilirani_interferon_alfa-2b"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="http://drugrxus.com/P/Peginterferon%20alfa-2b.htm">„Peginterferon alfa-2b”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Peginterferon+alfa-2b&rft.atitle=&rft_id=http%3A%2F%2Fdrugrxus.com%2FP%2FPeginterferon%2520alfa-2b.htm&rfr_id=info:sid/en.wikipedia.org:Pegilirani_interferon_alfa-2b"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Ward A. et al. "The Jak-Stat pathway in normal and perturbed hematopoiesis". <i>BLOOD</i>. January 2000; VOL 95, Number 1, 19-26</span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="http://www.networksandpathways.org/pathway?name=IFNalpha&description=IFN%20alpha">„PATHWAYS :: IFN alpha”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=PATHWAYS+%3A%3A+IFN+alpha&rft.atitle=&rft_id=http%3A%2F%2Fwww.networksandpathways.org%2Fpathway%3Fname%3DIFNalpha%26description%3DIFN%2520alpha&rfr_id=info:sid/en.wikipedia.org:Pegilirani_interferon_alfa-2b"><span style="display: none;"> </span></span><sup class="noprint Inline-Template"><span title=" since August 2021" style="white-space: nowrap;">[<i><a href="/wiki/Wikipedija:Mrtvi_eksterni_linkovi" title="Wikipedija:Mrtvi eksterni linkovi">mrtav link</a></i>]</span></sup></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">Thomas H. et al. "Mechanisms of Action of Interferon and Nucleoside Analogues". <i>Journal of hepatology</i>.2004 Feb; 40(2):364.</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">Sangfel O, Erickson S, et al. (1997). Cell Growth Differ.,8;343-352</span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text">Thyrell et al. “Mechanisms of Interferon-alpha induced apoptosis in malignant cells”. Oncogene: Nature Publishing Group. 2002. 21; 1251-1262</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text"><span class="citation Journal">Ge D, Fellay J, Thompson AJ, <i>et al.</i> (2009). „Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance”. <i>Nature</i> <b>461</b> (7262): 399–401. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fnature08309">10.1038/nature08309</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/19684573">19684573</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+variation+in+IL28B+predicts+hepatitis+C+treatment-induced+viral+clearance&rft.jtitle=Nature&rft.aulast=Ge+D%2C+Fellay+J%2C+Thompson+AJ%2C+%27%27et+al.%27%27&rft.au=Ge+D%2C+Fellay+J%2C+Thompson+AJ%2C+%27%27et+al.%27%27&rft.date=2009&rft.volume=461&rft.issue=7262&rft.pages=399%E2%80%93401&rft_id=info:doi/10.1038%2Fnature08309&rft_id=info:pmid/19684573&rfr_id=info:sid/en.wikipedia.org:Pegilirani_interferon_alfa-2b"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text"><span class="citation Journal">Thomas DL, Thio CL, Martin MP, <i>et al.</i> (2009). „Genetic variation in IL28B and spontaneous clearance of hepatitis C virus”. <i>Nature</i> <b>461</b> (7265): 798–801. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fnature08463">10.1038/nature08463</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/19759533">19759533</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+variation+in+IL28B+and+spontaneous+clearance+of+hepatitis+C+virus&rft.jtitle=Nature&rft.aulast=Thomas+DL%2C+Thio+CL%2C+Martin+MP%2C+%27%27et+al.%27%27&rft.au=Thomas+DL%2C+Thio+CL%2C+Martin+MP%2C+%27%27et+al.%27%27&rft.date=2009&rft.volume=461&rft.issue=7265&rft.pages=798%E2%80%93801&rft_id=info:doi/10.1038%2Fnature08463&rft_id=info:pmid/19759533&rfr_id=info:sid/en.wikipedia.org:Pegilirani_interferon_alfa-2b"><span style="display: none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&veaction=edit&section=4" title="Uredi odjeljak Spoljašnje veze" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Pegilirani_interferon_alfa-2b&action=edit&section=4" title="Uredi kôd odjeljka Spoljašnje veze"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="noprint tright portal" style="border:solid #aaa 1px;margin:0.5em 0 0.5em 0.5em;"> <table style="background:#f9f9f9; font-size:85%; line-height:110%; max-width:250px;"> <tbody><tr> <td style="text-align: center;"><span typeof="mw:File"><a href="/wiki/Datoteka:Portal.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/32px-Portal.svg.png" decoding="async" width="32" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/47px-Portal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/63px-Portal.svg.png 2x" data-file-width="36" data-file-height="32" /></a></span> </td> <td style="padding: 0 0.2em; vertical-align: middle"><i><b><a href="/w/index.php?title=Portal:Medicina&action=edit&redlink=1" class="new" title="Portal:Medicina (stranica ne postoji)">Portal Medicina </a></b></i> </td></tr> <tr valign="middle"> <td style="text-align: center;"><span typeof="mw:File"><a href="/wiki/Datoteka:P_chemistry.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/P_chemistry.svg/31px-P_chemistry.svg.png" decoding="async" width="31" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/P_chemistry.svg/47px-P_chemistry.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/ca/P_chemistry.svg/62px-P_chemistry.svg.png 2x" data-file-width="400" data-file-height="360" /></a></span> </td> <td style="padding: 0 0.2em; vertical-align: middle"><i><b><a href="/w/index.php?title=Portal:Hemija&action=edit&redlink=1" class="new" title="Portal:Hemija (stranica ne postoji)">Portal Hemija </a></b></i> </td></tr> </tbody></table></div> <ul><li><a rel="nofollow" class="external text" href="http://www.fda.gov/cder/biologics/products/pegsche011901.htm">"Informacija o FDA odobrenju"</a></li> <li><a rel="nofollow" class="external text" href="http://www.pegintron.com">"Peg Intron Vebsajt"</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180804195727/http://pegintron.com/">Arhivirano</a> 2018-08-04 na <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine-u</a></li> <li><a rel="nofollow" class="external text" href="http://www.druglib.com/adverse-reactions_side-effects/peg-intron/seriousness_death/reaction_platelet_count_decreased/">"Smrtni slučajevi vezani za upotrebu laka"</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20090404070747/http://www.druglib.com/adverse-reactions_side-effects/peg-intron/seriousness_death/reaction_platelet_count_decreased">Arhivirano</a> 2009-04-04 na <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine-u</a></li> <li><a href="/wiki/Medical_Subject_Headings" class="mw-redirect" title="Medical Subject Headings">MeSH</a> <i><a rel="nofollow" class="external text" href="//www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Peg+Intron">Peg+Intron </a></i></li></ul> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/Cytokines" title="Cytokines"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <a href="https://commons.wikimedia.org/wiki/Glavna_strana" class="extiw" title="commons:Glavna strana">Vikimedija ostava</a> ima još multimedijalnih fajlova vezanih za: <b><i><a href="https://commons.wikimedia.org/wiki/Category:Cytokines" class="extiw" title="commons:Category:Cytokines">Pegilirani interferon alfa-2b</a></i></b></li></ul> <div style="clear:both;"></div> <div class="navbox-styles nomobile"><style data-mw-deduplicate="TemplateStyles:r41348688">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}</style></div><div role="navigation" class="navbox" aria-labelledby="Ćelijska_komunikacija:_Citokini" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><style data-mw-deduplicate="TemplateStyles:r41556979">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r41556873">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-prikaži"><a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat"><abbr title="Pogledajte šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">p</abbr></a></li><li class="nv-razgovor"><a href="/wiki/Razgovor_o_%C5%A1ablonu:Citokini-lat" title="Razgovor o šablonu:Citokini-lat"><abbr title="Razgovarajte o šablonu" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a class="external text" href="https://sh.wikipedia.org/w/index.php?title=%C5%A0ablon:Citokini-lat&action=edit"><abbr title="Uredite šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Ćelijska_komunikacija:_Citokini" style="font-size:114%;margin:0 4em"><a href="/wiki/%C4%86elijska_komunikacija" title="Ćelijska komunikacija">Ćelijska komunikacija</a>: <a href="/wiki/Citokini" class="mw-redirect" title="Citokini">Citokini</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po familiji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-1" class="mw-disambig" title="IL-1">IL-1</a> superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_1" title="Interleukin 1">1</a> (<a href="/wiki/Antagonist_interleukin-1_receptora" title="Antagonist interleukin-1 receptora">1Ra</a>) •  <a href="/wiki/Interleukin_18" title="Interleukin 18">18</a> •  <a href="/wiki/Interleukin_33" title="Interleukin 33">33</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">poput <a href="/wiki/IL-6" class="mw-disambig" title="IL-6">IL-6</a>/<a href="/wiki/Glikoprotein_130" title="Glikoprotein 130">gp130</a> koristeći</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_6" title="Interleukin 6">6</a>  •  <a href="/wiki/Interleukin_11" title="Interleukin 11">11</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_30" title="Interleukin 30">30</a> •  <a href="/wiki/Interleukin_31" title="Interleukin 31">31</a> (+ne IL <a href="/wiki/Onkostatin_M" title="Onkostatin M">Onkostatin M</a>, <a href="/wiki/Inhibitorni_faktor_leukemije" title="Inhibitorni faktor leukemije">Inhibitorni faktor leukemije</a>, <a href="/wiki/Cilijarni_neurotrofni_faktor" title="Cilijarni neurotrofni faktor">Cilijarni neurotrofni faktor</a>, <a href="/wiki/Kardiotrofin_1" title="Kardiotrofin 1">Kardiotrofin 1</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-10" class="mw-disambig" title="IL-10">IL-10</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_10" title="Interleukin 10">10</a> •  <a href="/wiki/Interleukin_19" title="Interleukin 19">19</a> •  <a href="/wiki/Interleukin_20" title="Interleukin 20">20</a> •  <a href="/wiki/Interleukin_22" title="Interleukin 22">22</a> •  <a href="/wiki/Interleukin_24" title="Interleukin 24">24</a> •  <a href="/wiki/Interleukin_26" title="Interleukin 26">26</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">Interferon tip III</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_28" title="Interleukin 28">28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">29</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Zajedni%C4%8Dki_gama_lanac" class="mw-redirect" title="Zajednički gama lanac">Zajednički γ-lanac</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_2" title="Interleukin 2">2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">15</a> •  <a href="/wiki/Interleukin_3" title="Interleukin 3">3</a> •  <a href="/wiki/Interleukin_4" title="Interleukin 4">4</a> •  <a href="/wiki/Interleukin_7" title="Interleukin 7">7</a> •  <a href="/wiki/Interleukin_9" title="Interleukin 9">9</a> •  <a href="/wiki/Interleukin_13" title="Interleukin 13">13</a> •  <a href="/wiki/Interleukin_21" title="Interleukin 21">21</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-12" class="mw-disambig" title="IL-12">IL-12</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_12" title="Interleukin 12">12</a> (<a href="/wiki/Interleukin_12B" title="Interleukin 12B">B</a>) •  <a href="/wiki/Interleukin_23" title="Interleukin 23">23</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_35" title="Interleukin 35">35</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Drugi</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_5" title="Interleukin 5">5</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/Interleukin_14" title="Interleukin 14">14</a> •  <a href="/wiki/Interleukin_16" title="Interleukin 16">16</a> •  <a href="/wiki/Interleukin_17" title="Interleukin 17">17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">25</a> (<a href="/wiki/Interleukin_17A" title="Interleukin 17A">A</a>) •  <a href="/wiki/Interleukin_32" title="Interleukin 32">32</a>  •  <a href="/wiki/Interleukin_34" title="Interleukin 34">34</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Hemokini" class="mw-redirect" title="Hemokini">Hemokini</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CCL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CCL1" title="CCL1">1</a> •  <a href="/wiki/CCL2" title="CCL2">2</a> •  <a href="/wiki/Makrofagni_inflamatorni_protein" title="Makrofagni inflamatorni protein">3</a> •  <a href="/wiki/CCL4" title="CCL4">4</a> •  <a href="/wiki/CCL5" title="CCL5">5</a> •  <a href="/wiki/CCL6" title="CCL6">6</a> •  <a href="/wiki/CCL7" title="CCL7">7</a> •  <a href="/wiki/CCL8" title="CCL8">8</a> •  <a href="/wiki/CCL9" title="CCL9">9</a> •  <a href="/wiki/CCL9" title="CCL9">10</a> •  <a href="/wiki/CCL11" title="CCL11">11</a> •  <a href="/wiki/CCL12" title="CCL12">12</a> •  <a href="/wiki/CCL13" title="CCL13">13</a> •  <a href="/wiki/CCL14" title="CCL14">14</a> •  <a href="/wiki/CCL15" title="CCL15">15</a> •  <a href="/wiki/CCL16" title="CCL16">16</a> •  <a href="/wiki/CCL17" title="CCL17">17</a> •  <a href="/wiki/CCL18" title="CCL18">18</a> •  <a href="/wiki/CCL19" title="CCL19">19</a> •  <a href="/wiki/CCL20" title="CCL20">20</a> •  <a href="/wiki/CCL21" title="CCL21">21</a> •  <a href="/wiki/CCL22" title="CCL22">22</a> •  <a href="/wiki/CCL23" title="CCL23">23</a> •  <a href="/wiki/CCL24" title="CCL24">24</a> •  <a href="/wiki/CCL25" title="CCL25">25</a> •  <a href="/wiki/CCL26" title="CCL26">26</a> •  <a href="/wiki/CCL27" title="CCL27">27</a> •  <a href="/wiki/CCL28" title="CCL28">28</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CXCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CXCL1" title="CXCL1">1</a> •  <a href="/wiki/CXCL2" title="CXCL2">2</a> •  <a href="/wiki/CXCL3" title="CXCL3">3</a> •  <a href="/wiki/Trombocit_faktor_4" title="Trombocit faktor 4">4</a> •  <a href="/wiki/CXCL5" title="CXCL5">5</a> •  <a href="/wiki/CXCL6" title="CXCL6">6</a> •  <a href="/wiki/CXCL7" title="CXCL7">7</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/CXCL9" title="CXCL9">9</a> •  <a href="/wiki/CXCL10" title="CXCL10">10</a> •  <a href="/wiki/CXCL11" title="CXCL11">11</a> •  <a href="/wiki/CXCL12" title="CXCL12">12</a> •  <a href="/wiki/CXCL13" title="CXCL13">13</a> •  <a href="/wiki/CXCL14" title="CXCL14">14</a> •  <a href="/wiki/CXCL15" title="CXCL15">15</a> •  <a href="/wiki/CXCL16" title="CXCL16">16</a> •  <a href="/wiki/CXCL17" title="CXCL17">17</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CX3CL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CX3CL1" title="CX3CL1">1</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">XCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/XCL1" title="XCL1">1</a> •  <a href="/wiki/XCL2" title="XCL2">2</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Faktori_nekroze_tumora" title="Faktori nekroze tumora">TNF</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Glavni</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">TNF (<a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">ligand</a>) superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/4-1BB_ligand" title="4-1BB ligand">4-1BB ligand</a> •  <a href="/wiki/Faktor_aktivacije_B-%C4%87elija" title="Faktor aktivacije B-ćelija">Faktor aktivacije B-ćelija</a> •  <a href="/wiki/Fas_ligand" title="Fas ligand">FAS ligand</a> •  <a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a> •  <a href="/wiki/OX40L" title="OX40L">OX40L</a> •  <a href="/wiki/RANKL" title="RANKL">RANKL</a> •  <a href="/wiki/TRAIL" title="TRAIL">TRAIL</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Klaster_diferencijacije" title="Klaster diferencijacije">Klaster diferencijacije</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CD70" title="CD70">CD70</a> •  <a href="/wiki/CD153" title="CD153">CD153</a> •  <a href="/wiki/CD154" title="CD154">CD154</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon" title="Interferon">Interferon</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_I" title="Interferon tip I">I</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">alfa ( <a href="/wiki/Pegilirani_interferon_alfa-2a" title="Pegilirani interferon alfa-2a">Pegilirani 2a</a>, <a class="mw-selflink selflink">Pegilirani 2b</a>), beta (<a href="/wiki/Interferon_beta-1a" title="Interferon beta-1a">1a</a>, <a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">1b</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_II" title="Interferon tip II">II</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interferon-gama" title="Interferon-gama">Gama</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">III</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_28" title="Interleukin 28">IL-28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Drugi</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Monokin" title="Monokin">Monokin</a> •  <a href="/wiki/Limfokin" title="Limfokin">Limfokin</a> (<a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a>, <a href="/wiki/Faktor_transfera" title="Faktor transfera">Faktor transfera</a>) •  <a href="/wiki/Faktor_rasta" title="Faktor rasta">Faktor rasta</a> •  <a href="/wiki/Hematopoeza" title="Hematopoeza">Hematopoeza</a> (<a href="/wiki/Faktor_stem_%C4%87elija" title="Faktor stem ćelija">Faktor stem ćelija</a>, <a href="/wiki/Faktor_stimulacije_kolonije" title="Faktor stimulacije kolonije">Faktor stimulacije kolonije</a>) •  <a href="/wiki/GPI_(gen)" title="GPI (gen)">Faktor autokrinog motiliteta</a> •  <a href="/wiki/Osteopontin" title="Osteopontin">Osteopontin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po funkciji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><i><a href="/wiki/Proinflamatorni_citokin" title="Proinflamatorni citokin">proinflamatorni citokin</a></i> (<a href="/wiki/Interleukin_1" title="Interleukin 1">IL-1</a>, <a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>1</i></a> (<a href="/wiki/Interferon-gama" title="Interferon-gama">INF-gama</a> i <a href="/wiki/Faktor_nekroze_tumora-beta" class="mw-redirect" title="Faktor nekroze tumora-beta">TNF-beta</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>2</i></a> (<a href="/wiki/Interleukin_4" title="Interleukin 4">IL-4</a>, <a href="/wiki/Interleukin_5" title="Interleukin 5">IL-5</a>, <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a>, <a href="/wiki/Interleukin_10" title="Interleukin 10">IL-10</a>, <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a>) •  <a href="/wiki/T_pomo%C4%87ne_17_%C4%87elije" title="T pomoćne 17 ćelije"><i>T<sub>h</sub>17</i></a> (<a href="/wiki/Interleukin_17" title="Interleukin 17">IL-17</a>,<a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a>)</div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i><a href="/wiki/%C5%A0ablon:Biohemija_metanavs-lat" title="Šablon:Biohemija metanavs-lat">B</a> <a href="/wiki/%C5%A0ablon:Prenos_signala-lat" title="Šablon:Prenos signala-lat">trdu</a>: <a href="/w/index.php?title=%C5%A0ablon:Intercelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intercelularni signalni peptidi i proteini-lat (stranica ne postoji)">peptidi</a> (<a href="/wiki/%C5%A0ablon:Neuropeptidi-lat" title="Šablon:Neuropeptidi-lat">nrpl</a>/<a href="/wiki/%C5%A0ablon:Faktori_rasta-lat" title="Šablon:Faktori rasta-lat">grfl</a>/<a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat">cytl</a>/<a href="/wiki/%C5%A0ablon:Hormoni-lat" title="Šablon:Hormoni-lat">horl</a>), <a href="/w/index.php?title=%C5%A0ablon:Receptori_%C4%87elijske_povr%C5%A1ine-lat&action=edit&redlink=1" class="new" title="Šablon:Receptori ćelijske površine-lat (stranica ne postoji)">receptori</a> (<a href="/w/index.php?title=%C5%A0ablon:Ligand-kontrolisani_jonski_kanali-lat&action=edit&redlink=1" class="new" title="Šablon:Ligand-kontrolisani jonski kanali-lat (stranica ne postoji)">lgic</a>, <a href="/w/index.php?title=%C5%A0ablon:Enzim-vezani_receptori-lat&action=edit&redlink=1" class="new" title="Šablon:Enzim-vezani receptori-lat (stranica ne postoji)">enzr</a>, <a href="/wiki/%C5%A0ablon:G_protein_spregnuti_receptori-lat" title="Šablon:G protein spregnuti receptori-lat">gprc</a>, <a href="/wiki/%C5%A0ablon:Imunoglobulinska_superfamilija_imunskih_receptora-lat" title="Šablon:Imunoglobulinska superfamilija imunskih receptora-lat">igsr</a>, <a href="/w/index.php?title=%C5%A0ablon:Integrini-lat&action=edit&redlink=1" class="new" title="Šablon:Integrini-lat (stranica ne postoji)">intg</a>, <a href="/wiki/%C5%A0ablon:Neuropeptidni_receptori-lat" title="Šablon:Neuropeptidni receptori-lat">nrpr</a>/<a href="/wiki/%C5%A0ablon:Receptori_faktora_rasta-lat" title="Šablon:Receptori faktora rasta-lat">grfr</a>/<a href="/wiki/%C5%A0ablon:Citokinski_receptori-lat" class="mw-redirect" title="Šablon:Citokinski receptori-lat">cytr</a>), <a href="/w/index.php?title=%C5%A0ablon:Intracelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intracelularni signalni peptidi i proteini-lat (stranica ne postoji)">itra</a> (<a href="/w/index.php?title=%C5%A0ablon:Adapterski_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Adapterski proteini-lat (stranica ne postoji)">adap</a>, <a href="/wiki/%C5%A0ablon:Regulatori_GTP-vezuju%C4%87ih_proteina-lat" title="Šablon:Regulatori GTP-vezujućih proteina-lat">gbpr</a>, <a href="/w/index.php?title=%C5%A0ablon:Aktivacija_MAP_kinaze-lat&action=edit&redlink=1" class="new" title="Šablon:Aktivacija MAP kinaze-lat (stranica ne postoji)">mapk</a>), <a href="/w/index.php?title=%C5%A0ablon:Kalcjiumska_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:Kalcjiumska signalizacija-lat (stranica ne postoji)">calc</a>, <a href="/wiki/%C5%A0ablon:Lipidna_signalizacija-lat" title="Šablon:Lipidna signalizacija-lat">lipd</a>, signalni putevi (<a href="/w/index.php?title=%C5%A0ablon:Hedgehog_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hedgehog signalni put-lat (stranica ne postoji)">hedp</a>, <a href="/w/index.php?title=%C5%A0ablon:Wnt_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Wnt signalni put-lat (stranica ne postoji)">wntp</a>, <a href="/w/index.php?title=%C5%A0ablon:TGF_beta_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:TGF beta signalizacija-lat (stranica ne postoji)">tgfp</a>+<a href="/wiki/%C5%A0ablon:MAPK_ERK_signalni_put-lat" title="Šablon:MAPK ERK signalni put-lat">mapp</a>, <a href="/w/index.php?title=%C5%A0ablon:Notch_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Notch signalni put-lat (stranica ne postoji)">notp</a>, <a href="/w/index.php?title=%C5%A0ablon:JAK-STAT_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:JAK-STAT signalni put-lat (stranica ne postoji)">jakp</a>, <a href="/wiki/%C5%A0ablon:Apoptozni_signalni_put-lat" title="Šablon:Apoptozni signalni put-lat">fsap</a>, <a href="/w/index.php?title=%C5%A0ablon:Hippo_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hippo signalni put-lat (stranica ne postoji)">hipp</a>, <a href="/w/index.php?title=%C5%A0ablon:TLR_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:TLR signalni put-lat (stranica ne postoji)">tlrp</a>)</i></div></td></tr></tbody></table></div> <p><a href="/w/index.php?title=%C5%A0ablon:Imunostimulanti&action=edit&redlink=1" class="new" title="Šablon:Imunostimulanti (stranica ne postoji)">Šablon:Imunostimulanti</a> </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="" lang="sh-Latn" dir="ltr">Izvor: <a dir="ltr" href="https://sh.wikipedia.org/w/index.php?title=Pegilirani_interferon_alfa-2b&oldid=41866620">https://sh.wikipedia.org/w/index.php?title=Pegilirani_interferon_alfa-2b&oldid=41866620</a></div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Posebno:Kategorije" title="Posebno:Kategorije">Kategorije</a>: <ul><li><a href="/wiki/Kategorija:Interleukini" title="Kategorija:Interleukini">Interleukini</a></li><li><a href="/wiki/Kategorija:Antivirotici" title="Kategorija:Antivirotici">Antivirotici</a></li><li><a href="/wiki/Kategorija:Imunostimulanti" title="Kategorija:Imunostimulanti">Imunostimulanti</a></li><li><a href="/wiki/Kategorija:Depresogeni" title="Kategorija:Depresogeni">Depresogeni</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Sakrivene kategorije: <ul><li><a href="/wiki/Kategorija:Svi_%C4%8Dlanci_s_mrtvim_eksternim_linkovima" title="Kategorija:Svi članci s mrtvim eksternim linkovima">Svi članci s mrtvim eksternim linkovima</a></li><li><a href="/wiki/Kategorija:%C4%8Clanci_lekova_bez_strukture" title="Kategorija:Članci lekova bez strukture">Članci lekova bez strukture</a></li><li><a href="/wiki/Kategorija:Webarchive_template_wayback_links" title="Kategorija:Webarchive template wayback links">Webarchive template wayback links</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" lang="sh-Latn" dir="ltr"> <ul id="footer-info"> <li id="footer-info-lastmod"> Ova stranica je posljednji put izmijenjena 30. aprila 2024. u 18:12.</li> <li id="footer-info-copyright">Tekst je dostupan pod licencom <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-ShareAlike</a>; mogu se primijeniti i dodatni uslovi. Za više informacija pogledajte <a class="external text" href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use">Uslove korištenja</a>.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Pravila o privatnosti</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedija:O_projektu">O projektu</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedija:Op%C4%87e_odricanje_odgovornosti">Odricanje odgovornosti</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Kodeks ponašanja</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Programeri</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/sh.wikipedia.org">Statistika</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Izjava o kolačićima</a></li> <li id="footer-places-mobileview"><a href="//sh.m.wikipedia.org/w/index.php?title=Pegilirani_interferon_alfa-2b&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobilni prikaz</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-6b8d669998-gc94b","wgBackendResponseTime":168,"wgPageParseReport":{"limitreport":{"cputime":"0.344","walltime":"0.419","ppvisitednodes":{"value":7487,"limit":1000000},"postexpandincludesize":{"value":143176,"limit":2097152},"templateargumentsize":{"value":21367,"limit":2097152},"expansiondepth":{"value":17,"limit":100},"expensivefunctioncount":{"value":0,"limit":500},"unstrip-depth":{"value":0,"limit":20},"unstrip-size":{"value":14986,"limit":5000000},"entityaccesscount":{"value":0,"limit":400},"timingprofile":["100.00% 337.217 1 -total"," 56.60% 190.870 6 Šablon:Navbox"," 42.13% 142.079 1 Šablon:Reflist"," 37.69% 127.107 1 Šablon:Citokini"," 21.26% 71.697 5 Šablon:Navbox_subgroup"," 15.67% 52.858 1 Šablon:Dead_link"," 15.43% 52.028 6 Šablon:Citation/core"," 14.62% 49.312 1 Šablon:Fix"," 13.90% 46.871 1 Šablon:Category_handler"," 9.68% 32.642 1 Šablon:Drugbox-lat"]},"scribunto":{"limitreport-timeusage":{"value":"0.096","limit":"10.000"},"limitreport-memusage":{"value":1633496,"limit":52428800}},"cachereport":{"origin":"mw-api-int.codfw.main-5fd4fc67fd-hnrb2","timestamp":"20241105051131","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Pegilirani interferon alfa-2b","url":"https:\/\/sh.wikipedia.org\/wiki\/Pegilirani_interferon_alfa-2b","sameAs":"http:\/\/www.wikidata.org\/entity\/Q7160789","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q7160789","author":{"@type":"Organization","name":"Doprinositelji Wikimedijinim projektima"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2014-04-05T11:52:13Z","dateModified":"2024-04-30T17:12:34Z"}</script> </body> </html>