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id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <input type="hidden" name="ctl00$RootHolder$SortedValue" id="SortedValue" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">859</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (63)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (616)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Receptor, Cannabinoid, CB1/antagonists &amp; inhibitors</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div 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di Marzo V, Nicois A, Marfella B, Cristino L, Luongo L, Guida F, Candeletti S, Gobbi G, Romualdi P, Maione S. Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(17736);'>Neuropharmacology</em> 2025;<b>266</b>:110265. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39674399' target='_blank'>39674399</a> DOI: <a href='https://dx.doi.org/10.1016/j.neuropharm.2024.110265' target='_blank'>10.1016/j.neuropharm.2024.110265</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.neuropharm.2024.110265','39674399', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.neuropharm.2024.110265' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17736);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.neuropharm.2024.110265" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cannabidiol has been shown to ameliorate neuropathic pain and its affective components. Previous studies highlighted the pharmacological interaction between the CBD and opioid system, particularly the MOR, but the understanding of the interaction between CBD and kappa opioid receptor (KOR), physiologically stimulated by the endogenous opioid dynorphin, remains elusive. We assessed the pharmacological interactions between CBD and nor-BNI, a selective KOR antagonist in a rat neuropathic pain model. We show an increase in dynorphin peptide and its KOR receptors in the hippocampus' dentate gyrus (DG) of neuropathic rats showing allodynia, and memory deficits. Consistent with these findings, neuropathic pain was associated with long-term potentiation (LTP) impairment in the entorhinal cortex-DG, also referred to as the lateral perforant pathway (LPP). Moreover, a downregulation of the endocannabinoid 2-AG and an upregulation of the cannabinoid CB1 receptors in the DG were detected in neuropathic pain animals. Either an acute KOR antagonist administration or one-week CBD treatment normalized dynorphin levels and improved affective symptoms, LTP and receptor expression, whereas only CBD showed an anti-allodynic effect. In addition, CBD normalized the SNI-induced changes in neuroplasticity as well as endocannabinoid and GABA levels in the DG. Noteworthy, the acute blockade of the KOR carried out after CBD repeated administration causes the re-installment of some neuropathic condition symptoms. As a whole, these original results indicate a critical relationship between the adaptive changes in the hippocampus produced by CBD and the need to maintain the recovered physiological dynorphin tone to preserve the therapeutic effect of CBD in neuropathic rats. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabidiol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabidiol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognition</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Murrieta AC</b>, Mendoza-Espinosa P, Velasco-Bolom JL, Contreras-Torres FF. Identification and structural characterization of CB1 receptor antagonists: A comprehensive virtual screening and molecular dynamics study of arachidin-2. <em class='incite-journal-name' onclick='ShowInCiteJournal(3689);'>Biophys Chem</em> 2025;<b>318</b>:107385. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39721421' target='_blank'>39721421</a> DOI: <a href='https://dx.doi.org/10.1016/j.bpc.2024.107385' target='_blank'>10.1016/j.bpc.2024.107385</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bpc.2024.107385','39721421', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.bpc.2024.107385' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3689);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.bpc.2024.107385" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The cannabinoid receptor 1 (CB1) is an essential component of the endocannabinoid system, responsible for regulating various physiological processes such as pain, mood, and appetite. Despite increasing interest in the therapeutic potential of CB1 modulators, the precise mechanisms by which small molecules modulate receptor activity-particularly without fully transitioning between active and inactive states-remain partially understood. In this study, the complexity of CB1-ligand interactions was evaluated for the inactive CB1 state. A comprehensive pipeline, integrating ligand-based similarity search, 2D fingerprint-based reverse virtual screening and molecular dynamics (MD) simulations, identified compounds with core scaffolds commonly found in bioactive natural products, such as stilbenoids and polyphenolic compounds. Arachidin-2 (AR2) and a polyphenolic derivative were subjected to extended MD simulations, revealing their ability to stabilize the inactive CB1 state across key helices. The distinct stability differences observed in the helices HI, HIV, and HVI of the active CB1 state further highlighted ligand-specific conformational dynamics. A comparative analysis with co-crystallized synthetic ligands AM6538 and AM841 demonstrated the distinct binding behaviors of natural and synthetic ligands. AR2 showed more favorable binding to the inactive form (-22.0 kcal/mol) than to the active state. Similarly, the polyphenolic compound exhibited a greater binding difference (∼6 kcal/mol) between the inactive and active states. Notably, AM6538 and AM841 demonstrated the strongest binding (∼30 kcal/mol) to the inactive and active state, respectively. Key residues stabilizing the identified compounds in CB1-inactive state included PHE102, GLY166, PHE170, VAL196, LEU359, SER383, and CIS386. These findings underscore the utility of computational methods in the discovery and development of novel CB1 modulators for potential biomedical applications. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antagonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arachidin-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arachidin-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB1+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB1 receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+docking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular docking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+dynamics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular dynamics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stilbenoids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stilbenoids</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Dynamics+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Dynamics Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ligands%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ligands</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Evaluation%2c+Preclinical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Evaluation, Preclinical</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Structure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Structure</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Aloisio Caruso E</b>, De Nunzio V, Tutino V, Notarnicola M. The Endocannabinoid System: Implications in Gastrointestinal Physiology and Pathology. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2025;<b>26</b>:1306. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39941074' target='_blank'>39941074</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11818434' target='_blank'>PMC11818434</a> DOI: <a href='https://dx.doi.org/10.3390/ijms26031306' target='_blank'>10.3390/ijms26031306</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms26031306','39941074', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3390/ijms26031306' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/ijms26031306');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/10/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/31/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/02/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/16/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.3390/ijms26031306" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The endocannabinoid system (ECS), composed of receptors, endocannabinoids, and enzymes that regulate biosynthesis and degradation, plays a fundamental role in the physiology and pathology of the gastrointestinal tract, particularly in the small and large intestine and liver. Specifically, cannabinoid receptor type 1 (CB1R) and cannabinoid receptor type 2 (CB2R), located principally in the nervous system and immune cells, orchestrate processes such as intestinal motility, intestinal and hepatic inflammation, and energy metabolism, respectively. The main endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), influence appetite, body weight regulation, and inflammatory states and thus have implications in obesity, non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS). Recent studies have highlighted the therapeutic potential of targeting the ECS to modulate gastrointestinal and metabolic diseases. In particular, peripheral CB1R antagonists and CB2R agonists have shown efficacy in treating intestinal inflammation, reducing hepatic steatosis, and controlling IBS symptoms. Moreover, the ECS is emerging as a potential target for the treatment of colorectal cancer, acting on cell proliferation and apoptosis. This review highlights the opportunity to exploit the endocannabinoid system in the search for innovative therapeutic strategies, emphasizing the importance of a targeted approach to optimize treatment efficacy and minimize side effects. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">colorectal cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endocannabinoid+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endocannabinoid system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastrointestinal+physiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastrointestinal physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22irritable+bowel+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">irritable bowel syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22non-alcoholic+fatty+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">non-alcoholic fatty liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">obesity</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Tract%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Tract/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Tract%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Tract/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Cannabinoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Cannabinoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irritable+Bowel+Syndrome%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irritable Bowel Syndrome/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irritable+Bowel+Syndrome%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irritable Bowel Syndrome/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irritable+Bowel+Syndrome%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irritable Bowel Syndrome/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Diseases/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministero+della+Salute%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DDG 851/23 Ministero della Salute</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Rodriguez CEB</b>, Vanegas SO, Reck AM, Schrom Y, Kinsey SG. Combined Endocannabinoid and Cyclooxygenase Inhibition Additively Attenuates Post-Surgical Pain. <em class='incite-journal-name' onclick='ShowInCiteJournal(4489);'>Cannabis Cannabinoid Res</em> 2025;<b>10</b>:e102-e111. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39899366' target='_blank'>39899366</a> DOI: <a href='https://dx.doi.org/10.1089/can.2024.0088' target='_blank'>10.1089/can.2024.0088</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1089/can.2024.0088','39899366', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1089/can.2024.0088' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4489);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/04/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1089/can.2024.0088" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Introduction: Post-surgical pain arises following a clinical operation, often persisting throughout recovery. While current treatments reduce pain, repeated use increases the probability of adverse events. monoacylglycerol lipase (MAGL) inhibition has previously been shown to produce analgesia, either through CB1 or CB2 mechanisms, dependent on the underlying pain phenotype. Thus, this study investigated the analgesic potential of inhibiting MAGL, alone and in combination with the analgesic non-steroidal anti-inflammatory drug (NSAID) diclofenac sodium in a model of post-surgical pain. Methods: Male and female C57BL/6J mice were subjected to hindpaw incision (HPI) surgery. Mechanical allodynia, climbing, grip strength, and thermal preference were measured 24 h following HPI. The dose-dependent anti-allodynic effects of the MAGL inhibitors (irreversible MAGL inhibitor [JZL184] and selective MAGL inhibitor [MJN110]) and the NSAID diclofenac, as well as the additive potential of combined MAGL and cyclooxygenase (COX) inhibition, were assessed. Selective antagonists of CB1 and CB2 receptors were used to challenge the cannabinoid-receptor mechanism of JZL184. Similarly, the anti-allodynic effects of the CB2-selective agonist (LY2828360) were tested. JZL184 was administered repeatedly to determine tolerance. Finally, hindpaw cytokines were quantified via multiplex ELISA 24 h after HPI surgery. Results: Approximately 24 h post-surgery, the MAGL inhibitors JZL184 (≥4 mg/kg) or MJN110 (≥5 mg/kg), as well as the NSAID diclofenac sodium (≥16.67 mg/kg), attenuated HPI-induced mechanical allodynia, as assessed with von Frey filaments. The anti-allodynic effects of JZL184 (40 mg/kg) were blocked by pre-treatment of the CB2 antagonist SR144528 (3 mg/kg) but not the CB1-selective antagonist rimonabant (SR141716A; 3 mg/kg), suggesting a CB2-mediated mechanism of anti-allodynia via MAGL inhibition. Similarly, LY2828360 (3 mg/kg) reduced HPI-induced allodynia. Moreover, when administered repeatedly, the anti-allodynic effects of JZL184 (8 mg/kg) persisted and did not undergo tolerance. A separate cohort was administered a sub-analgesic dose of JZL184 (1 mg/kg), diclofenac sodium (1.85 mg/kg), or both compounds concurrently. This subthreshold JZL184 and diclofenac sodium combination attenuated HPI-induced allodynia, suggesting an additive drug interaction. Finally, HPI per se increased pro-inflammatory cytokine levels, which were unaltered by MAGL inhibition despite the anti-allodynia assessed behaviorally. Conclusion: These data support simultaneously targeting endocannabinoids and COX enzymes as a potential post-operative pain management approach. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB2+cannabinoid+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB2 cannabinoid receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAGL+inhibition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAGL inhibition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endocannabinoid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endocannabinoid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hindpaw+incision%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hindpaw incision</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22post-surgical+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">post-surgical pain</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diclofenac%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diclofenac/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pain%2c+Postoperative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pain, Postoperative/drug therapy</a></li><li><a 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target="_blank">Succinimides</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Gonçalves de Queiroz BF</b>, Cristina de Sousa Fonseca F, Pinto Barra WC, Viana GB, Irie AL, de Castro Perez A, Lima Romero TR, Gama Duarte ID. Interaction between the dopaminergic and endocannabinoid systems promotes peripheral antinociception. <em class='incite-journal-name' onclick='ShowInCiteJournal(8802);'>Eur J Pharmacol</em> 2025;<b>987</b>:177195. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39662656' target='_blank'>39662656</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejphar.2024.177195' target='_blank'>10.1016/j.ejphar.2024.177195</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejphar.2024.177195','39662656', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.ejphar.2024.177195' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8802);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.ejphar.2024.177195" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Dopamine has been widely related to pain modulation, at central and peripheral levels. In this study we aimed to investigate the mechanisms involved in peripheral antinociception, evaluating the interaction between the dopaminergic and endocannabinoid systems in this event. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Male Swiss mice (30-40 g) were pre-sensitized by administration of the hyperalgesic PGE2 (2 μg/paw). The nociceptive threshold was measured using the paw withdrawal test. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Dopamine (80 ng/paw) promoted antinociception. This effect was reversed by the CB1 and CB2 cannabinoid receptor antagonists AM251 (20, 40, and 80 μg/paw) and AM630 (25, 50, and 100 μg/paw). JZL (4 μg/paw), an inhibitor of the degradation of the 2-arachidonylglycerol (2-AG), potentiated the antinociceptive action of the submaximal dose of dopamine (5 ng/paw). While anandamide degradation and reuptake inhibitors (MAFP 0.5 μg/paw and VDM11 2.5 μg/paw) did not promote changes in intermediate antinociception induced by dopamine. Anandamide at a submaximal dose (12.5 ng/paw) promoted intermediate antinociception that was not potentiated by the administration of the dopamine reuptake inhibitor GBR 12783 (16 μg/paw). In contrast, the administration of GBR potentiated the intermediate antinociception induced by a submaximal dose of 2-AG (10 μg/paw). Furthermore, the dopaminergic receptor antagonists D2 Remoxipride (4 μg/paw) and D3 U99194 (16 μg/paw) reversed the antinociception mediated by the maximum dose of this endocannabinoid (20 μg/paw). In contrast, the D4 receptor antagonist L-745,870 (16 μg/paw) did not change the nociceptive threshold. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">In this way, we demonstrate the interaction between the dopaminergic and endocannabinoid systems to promote analgesia peripherally. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Analgesia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Analgesia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dopamine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dopamine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peripheral+antinociception%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peripheral antinociception</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Senthil Kumar KJ</b>, Gokila Vani M, Dakpa G, Wang SY. Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type-1 antagonistic mechanism and alters cellular metabolism in intestinal epithelial cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(3495);'>Biofactors</em> 2025;<b>51</b>:e2106. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39143845' target='_blank'>39143845</a> DOI: <a href='https://dx.doi.org/10.1002/biof.2106' target='_blank'>10.1002/biof.2106</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/biof.2106','39143845', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1002/biof.2106' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3495);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/biofactors' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1002/biof.2106" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Limonene, a dietary monocyclic monoterpene commonly found in citrus fruits and various aromatic plants, has garnered increasing interest as a gastrointestinal protectant. This study aimed to assess the effects of limonene on intestinal epithelial barrier function and investigate the involvement of cannabinoid receptor type-1 (CB1R) in vitro. Additionally, the study focused on examining the metabolomic changes induced by limonene in the intestinal epithelial cells (Caco-2). Initial analysis of transepithelial electrical resistance (TEER) revealed that both l-limonene and d-limonene, isomers of limonene, led to a dose- and time-dependent increase in TEER in normal cells and those inflamed by pro-inflammatory cytokines mixture (CytoMix). Furthermore, both types of limonene reduced CytoMix-induced paracellular permeability, as demonstrated by a decrease in Lucifer yellow flux. Moreover, d-limonene and l-limonene treatment increased the expression of tight junction molecules (TJs) such as occludin, claudin-1, and ZO-1, at both the transcriptional and translational levels. d-Limonene upregulates E-cadherin, a molecule involved in adherens junctions (AJs). Mechanistic investigations demonstrated that d-limonene and l-limonene treatment significantly inhibited CB1R at the protein, while the mRNA level remained unchanged. Notably, the inhibitory effect of d-limonene on CB1R was remarkably similar to that of pharmacological CB1R antagonists, such as rimonabant and ORG27569. d-limonene also alters Caco-2 cell metabolites. A substantial reduction in β-glucose and 2-succinamate was detected, suggesting limonene may impact intestinal epithelial cells' glucose uptake and glutamate metabolism. These findings suggest that d-limonene's CB1R antagonistic property could effectively aid in the recovery of intestinal barrier damage, marking it a promising gastrointestinal protectant. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB1R%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB1R</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adherence+junction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adherence junction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intestinal+epithelial+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intestinal epithelial cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22limonene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">limonene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolites%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolites</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tight+junction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tight junction</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Limonene%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Limonene/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Limonene%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Limonene/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caco-2+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caco-2 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Dorsomedial Striatum (DMS) CB1R Signaling Promotes Pavlovian Devaluation Sensitivity in Male Long Evans Rats and Reduces DMS Inhibitory Synaptic Transmission in Both Sexes. <em class='incite-journal-name' onclick='ShowInCiteJournal(8414);'>eNeuro</em> 2025;<b>12</b>:ENEURO.0341-24.2024. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39746803' target='_blank'>39746803</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779511' target='_blank'>PMC11779511</a> DOI: <a href='https://dx.doi.org/10.1523/eneuro.0341-24.2024' target='_blank'>10.1523/eneuro.0341-24.2024</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1523/eneuro.0341-24.2024','39746803', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1523/eneuro.0341-24.2024' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8414);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/04/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1523/eneuro.0341-24.2024" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cannabinoid receptor-1 (CB1R) signaling in the dorsal striatum regulates the shift from flexible to habitual behavior in instrumental outcome devaluation. Based on prior work establishing individual-, sex-, and experience-dependent differences in pavlovian behaviors, we predicted a role for dorsomedial striatum (DMS) CB1R signaling in driving rigid responding in pavlovian autoshaping and outcome devaluation. We trained male and female Long Evans rats in pavlovian lever autoshaping (PLA). We gave intra-DMS infusions of the CB1R inverse agonist, rimonabant, before satiety-induced outcome devaluation test sessions, where we sated rats on training pellets or home cage chow and tested them in brief nonreinforced PLA sessions. Overall, inhibition of DMS CB1R signaling prevented pavlovian outcome devaluation but did not affect behavior in reinforced PLA sessions. Males were sensitive to devaluation while females were not, and DMS CB1R blockade impaired devaluation sensitivity in males. Because these results suggest DMS CB1R signaling supports flexible responding, we investigated how DMS CB1R signaling impacts local inhibitory synaptic transmission in male and female Long Evans rats. We recorded spontaneous inhibitory postsynaptic currents (sIPSC) from DMS neurons at baseline and after application of a CB1R agonist, WIN 55,212-2. We found that male rats showed decreased sIPSC frequency compared with females and that CB1R activation reduced DMS inhibitory transmission independent of sex. Altogether our results demonstrate that DMS CB1Rs regulate pavlovian devaluation sensitivity and DMS inhibitory synaptic transmission and suggest that basal sex differences in inhibitory synaptic transmission may underly sex differences in DMS function and behavioral flexibility. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22devaluation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">devaluation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dorsal+striatum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dorsal striatum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endocannabinoids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endocannabinoids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pavlovian+conditioning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pavlovian conditioning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sex+differences%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sex differences</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Long-Evans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Long-Evans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rimonabant%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rimonabant/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synaptic+Transmission%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synaptic Transmission/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synaptic+Transmission%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synaptic Transmission/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Conditioning%2c+Classical%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Conditioning, Classical/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Conditioning%2c+Classical%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Conditioning, Classical/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Corpus+Striatum%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Corpus Striatum/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Corpus+Striatum%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Corpus Striatum/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+Characteristics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex Characteristics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inhibitory+Postsynaptic+Potentials%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inhibitory Postsynaptic Potentials/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inhibitory+Postsynaptic+Potentials%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inhibitory Postsynaptic Potentials/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+Receptor+Antagonists%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid Receptor Antagonists/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DA043533 NIDA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22School+of+Medicine%2c+University+of+Maryland+(UMSOM)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">School of Medicine, University of Maryland (UMSOM)</a></li></ul> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Ramshini E</b>, Shabani M. Cannabinoid receptor type 1 agonist disrupts methamphetamine-induced conditioned place preference in adolescent male rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(17886);'>Neurosci Lett</em> 2025;<b>844</b>:138033. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39489281' target='_blank'>39489281</a> DOI: <a href='https://dx.doi.org/10.1016/j.neulet.2024.138033' target='_blank'>10.1016/j.neulet.2024.138033</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.neulet.2024.138033','39489281', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.neulet.2024.138033' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17886);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.neulet.2024.138033" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Addiction can be viewed as a state of compulsive engagement in drug use. It is believed that drug-associated memories maintain compulsive drug-seeking behavior. Therefore, disrupting drug-associated memories may reduce drug-seeking behavior. In the present study, a conditioned place preference (CPP) apparatus was conducted to evaluate the effect of cannabinoid receptor type 1 (CB1R) agonist and antagonist on the acquisition of CPP induced by methamphetamine (METH). Anxiety behaviors and memory retrieval were assessed using elevated plus maze (EPM) and step-through passive avoidance tasks. In this study using a 5-day schedule of CPP, exposure to METH increased the time spent in the drug-paired compartment, and CB1Rs agonist (WIN 55,212-2, WIN) disrupted the METH-induced CPP. In the EPM experiment, METH significantly decreased the ratio of times spent in the open arms to total times spent in any arms (OAT) and the ratio of entries into open arms to total entries (OAE), indicating that METH increases anxiety-like behaviors. However, the CB1Rs antagonist (SR141716A, SR) reversed METH-induced anxiety behaviors. The results obtained in the passive avoidance experiment showed that blockade of brain CB1Rs by SR improves METH-induced amnesia. In summary, CB1Rs appear to modulate METH-associated memories, and antagonists of CB1Rs may serve as a therapeutic target for METH-induced anxiety behaviors. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+receptor+type+1+agonist%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid receptor type 1 agonist</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+receptor+type+1+antagonist%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid receptor type 1 antagonist</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoid+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoid system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methamphetamine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methamphetamine</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methamphetamine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methamphetamine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+Receptor+Agonists%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid Receptor Agonists/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Naphthalenes%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Naphthalenes/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Morpholines%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Morpholines/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzoxazines%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzoxazines/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rimonabant%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rimonabant/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%2fpsychology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety/psychology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Avoidance+Learning%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Avoidance Learning/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Central+Nervous+System+Stimulants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Central Nervous System Stimulants/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Xue J</b>, Xu Z, Zhang J, Hou H, Ge L, Yang K. Systematic review/meta-analysis on the role of CB1R regulation in sleep-wake cycle in rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(168342);'>J Evid Based Med</em> 2024;<b>17</b>:714-728. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39325651' target='_blank'>39325651</a> DOI: <a href='https://dx.doi.org/10.1111/jebm.12643' target='_blank'>10.1111/jebm.12643</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/jebm.12643','39325651', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/jebm.12643' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168342);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/jemd/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1111/jebm.12643" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">A systematic review/meta-analysis was conducted to investigate the effect of cannabinoid type-1 receptor (CB1R) regulation on the sleep-wake cycle of rats and to provide new ideas and evidence-based basis for clinical research on the treatment of sleep disorders. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We searched Cochrane Library, PubMed, Web of Science, Embase, Chinese Biomedicine Literature Database (CBM), China National Knowledge Infrastructure, WanFang, and VIP databases for relevant papers, about the effects of CB1R agonists/antagonists on sleep-wake cycle in rats, from inception to November 2023. Two reviewers performed study screening, data extraction, and risk of bias assessment using the SYRCLE's risk of bias tool. Meta-analysis was performed using RevMan 5.3 software. Heterogeneity test was performed on the included studies (Test standard α = 0.1). I2 value was used to evaluate the heterogeneity. Forest plot was drawn, and p ≤ 0.05 indicates statistically significant difference. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">A total of 16 trials involving 484 experimental rats were included. The methodological quality evaluation results showed that the overall quality of the included studies was low. The results of the meta-analysis showed that single administration of CB1R agonists could shorten the wakefulness (W) time in the first 6 h (h) (standardized mean difference (SMD) = -2.52, 95% confidence interval (CI) (-3.83, -1.22), p = 0.0002) and 24 h (SMD = -0.84, 95% CI (-1.31, -0.36), p = 0.0005) after administration, prolong nonrapid eye movement sleep (NREM) time (SMD = 1.75, 95% CI (0.54, 2.95), p = 0.005) and rapid eye movement sleep (REM) time (SMD = 1.76, 95% CI (0.26, 3.26), p = 0.02), and increase REM frequency after administration (SMD = 1.67, 95% CI (0.98, 2.35), p < 0.00001), these results were all statistically different. There were no significant differences in sleep latency and average duration of REM. Single administration of CB1R antagonists prolonged the first 6 h W time after administration (SMD = 1.36, 95%CI (0.29, 2.43), p = 0.01), shortened the first 6 h NREM time (SMD = -1.73, 95% CI (-2.88, -0.57), p = 0.003) and REM time (SMD = -2.07, 95% CI (-3.17, -0.96), p = 0.0003) after administration, and increased the frequency of W after administration (SMD = 3.57, 95% CI (1.42, 5.72), p = 0.001). There was no statistical difference in the average duration of W. REM time and REM frequency increased after continuous CB1R agonist withdrawal. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">According to the existing evidence, CB1R played a pivotal role in regulating the sleep-wake cycle in rats. CB1R agonists tended to reduce W time, increase NREM and REM sleep times, boost REM frequency, and promote sleep. Conversely, CB1R antagonists could increase the duration and frequency of W, shorten NREM and REM sleep times, and promote W. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cannabinoid+type+1+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cannabinoid type 1 receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22meta%e2%80%90analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">meta‐analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sleep%e2%80%90wake+cycle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sleep‐wake cycle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22systematic+review%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">systematic review</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wakefulness%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wakefulness/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Circadian+Rhythm%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Circadian Rhythm/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gansu+Province+Science+and+Technology+Foundation+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">23JRRA1251 Gansu Province Science and Technology Foundation Project</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Cho H</b>, Oh DE, Nam Y, Lee SH, Kim TH. Bioelectronic sensing platform emulating the human endocannabinoid system for assessing and modulating of cannabinoid activity. <em class='incite-journal-name' onclick='ShowInCiteJournal(3874);'>Biosens Bioelectron</em> 2024;<b>264</b>:116686. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39173339' target='_blank'>39173339</a> DOI: <a href='https://dx.doi.org/10.1016/j.bios.2024.116686' target='_blank'>10.1016/j.bios.2024.116686</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bios.2024.116686','39173339', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bios.2024.116686' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3874);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.bios.2024.116686" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cannabinoids are involved in physiological and neuromodulatory processes through their interactions with the human cannabinoid receptor-based endocannabinoid system. Their association with neurodegenerative diseases and brain reward pathways underscores the importance of evaluating and modulating cannabinoid activity for both understanding physiological mechanisms and developing therapeutic drugs. The use of agonists and antagonists could be strategic approaches for modulation. In this study, we introduce a bioelectronic sensor designed to monitor cannabinoid binding to receptors and assess their agonistic and antagonistic properties. We produced human cannabinoid receptor 1 (hCB1R) via an Escherichia coli expression system and incorporated it into nanodiscs (NDs). These hCB1R-NDs were then immobilized on a single-walled carbon nanotube field-effect transistor (swCNT-FET) to construct a bioelectronic sensing platform. This novel system can sensitively detect the cannabinoid ligand anandamide (AEA) at concentrations as low as 1 fM, demonstrating high selectivity and real-time response. It also successfully identified the hCB1R agonist Δ9-tetrahydrocannabinol and observed that the hCB1R antagonist rimonabant diminished the sensor signal upon AEA binding, indicating the antagonism-based modulation of ligand interaction. Consequently, our bioelectronic sensing platform holds potential for ligand detection and analysis of agonism and antagonism. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosensing+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosensing Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanotubes%2c+Carbon%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanotubes, Carbon/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transistors%2c+Electronic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transistors, Electronic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyunsaturated+Alkamides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyunsaturated Alkamides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyunsaturated+Alkamides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyunsaturated Alkamides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arachidonic+Acids%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arachidonic Acids/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arachidonic+Acids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arachidonic Acids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+Receptor+Agonists%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid Receptor Agonists/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dronabinol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dronabinol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dronabinol%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dronabinol/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Escherichia+coli%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Escherichia coli/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Escherichia+coli%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Escherichia coli/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Alayoubi M</b>, Henry BA, Cahill CM, Cooper ZD. Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action. <em class='incite-journal-name' onclick='ShowInCiteJournal(7946);'>Drugs</em> 2024;<b>84</b>:1395-1417. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39388076' target='_blank'>39388076</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602823' target='_blank'>PMC11602823</a> DOI: <a href='https://dx.doi.org/10.1007/s40265-024-02098-1' target='_blank'>10.1007/s40265-024-02098-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s40265-024-02098-1','39388076', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s40265-024-02098-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7946);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1007/s40265-024-02098-1" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">With rapid expansion of cannabis legalization worldwide, rates of cannabis use and cannabis use disorder (CUD) are increasing; the need for safe and effective medications to treat CUD is urgent. This narrative review evaluates evidence for promising pharmacotherapies to treat CUD from randomized, placebo-controlled trials. Pharmacotherapies for CUD are categorized based on compound targets (e.g., cannabinoid receptor 1 [CB1] agonists such as nabilone, serotonergic compounds such as bupropion, GABAergic compounds such as zolpidem) and outcomes are organized by predetermined withdrawal symptoms, cannabis craving, and cannabis relapse/use. Most promising pharmacotherapies for CUD are drugs that act on the endocannabinoid system and specifically at the CB1 receptor. Priority populations such as females, certain racial/ethnic groups, and age groups experience a different course of CUD progression, symptoms, and drug effects that are important to consider when evaluating outcomes related to CUD. Possible explanations for these disparities are explored, along with the clinical trials that explore these demographics in treating CUD with pharmacotherapies. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Marijuana+Abuse%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Marijuana Abuse/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Randomized+Controlled+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Randomized Controlled Trials as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Substance+Withdrawal+Syndrome%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Substance Withdrawal Syndrome/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+Receptor+Agonists%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid Receptor Agonists/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+Receptor+Agonists%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid Receptor Agonists/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+Research+Program%2c+National+Institute+on+Drug+Abuse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DA047296S1 Intramural Research Program, National Institute on Drug Abuse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DA057252 NIDA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+Research+Program%2c+National+Institute+on+Drug+Abuse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DA047296 Intramural Research Program, National Institute on Drug Abuse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R25 DA050723 NIDA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DA047296 NIDA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+Research+Program%2c+National+Institute+on+Drug+Abuse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DA057252 Intramural Research Program, National Institute on Drug Abuse</a></li></ul> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Yang H</b>, Park M, Lee JH, Kim B, Moon CS, Bae S, Kim Y, Lee HJ, Park CY. New peripherally-restricted CB1 receptor antagonists, PMG-505-010 and -013 ameliorate obesity-associated NAFLD and fibrosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3668);'>Biomed Pharmacother</em> 2024;<b>180</b>:117501. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366030' target='_blank'>39366030</a> DOI: <a href='https://dx.doi.org/10.1016/j.biopha.2024.117501' target='_blank'>10.1016/j.biopha.2024.117501</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biopha.2024.117501','39366030', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biopha.2024.117501' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3668);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.biopha.2024.117501" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The endocannabinoid system plays a crucial role in metabolic regulation, prompting the investigation of cannabinoid type 1 receptor (CB1R) antagonists for obesity and its complications like non-alcoholic fatty liver disease (NAFLD). Concerns over psychiatric side effects led to the development of peripheral CB1R antagonists that circumvent the blood-brain barrier (BBB). In this study, we synthesized PMG-505-010 and PMG-505-013 as peripherally restricted CB1 receptor antagonists by modifying rimonabant to minimize BBB penetration. Physicochemical analysis confirmed their reduced lipophilicity and increased polarity compared to rimonabant, indicating limited brain exposure. Molecular docking studies revealed similar binding modes to rimonabant at CB1R, characterized by robust hydrophobic interactions. Functionally, they acted as CB1R antagonists and inverse agonists, effectively reversing CP55,940-induced cAMP inhibition. In a murine model of obesity-related NAFLD, PMG-505-010 and -013 improved metabolic profiles, including fasting blood glucose levels and dyslipidemia. They also ameliorated hepatic injury, steatosis, and inflammation, evidenced by reduced liver enzymes, lipid peroxidation, hepatic lipid levels, and inflammatory cytokine levels. Notably, these compounds inhibited hepatic fibrosis by reducing extracellular matrix (ECM) deposition and altering fibrosis-related gene and protein expressions. In conclusion, PMG-505-010 and PMG-505-013 hold promise for treating obesity-related liver diseases, including NAFLD and fibrosis, through selective peripheral CB1R targeting, potentially avoiding CNS-related side effects seen with earlier CB1R antagonists. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+type+1+receptor+(CB1R)+antagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid type 1 receptor (CB1R) antagonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoid+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoid system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hepatic+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hepatic fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nonalcoholic+fatty+liver+disease+(NAFLD)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nonalcoholic fatty liver disease (NAFLD)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22peripheral+CB1R+targeting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">peripheral CB1R targeting</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-alcoholic+Fatty+Liver+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-alcoholic Fatty Liver Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rimonabant%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rimonabant/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+Receptor+Antagonists%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid Receptor Antagonists/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Atwal N</b>, Sokolaj E, Mitchell VA, Winters BL, Vaughan CW. Disrupted stress-induced analgesia in a neuropathic pain state is rescued by the endocannabinoid degradation inhibitor JZL195. <em class='incite-journal-name' onclick='ShowInCiteJournal(14695);'>J Neurochem</em> 2024;<b>168</b>:3801-3812. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38922705' target='_blank'>38922705</a> DOI: <a href='https://dx.doi.org/10.1111/jnc.16146' target='_blank'>10.1111/jnc.16146</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/jnc.16146','38922705', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/jnc.16146' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14695);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1111/jnc.16146" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Acute stress normally engages descending brain pathways to produce an antinociceptive response, known as stress-induced analgesia. Paradoxically, these descending pain modulatory pathways are also involved in the maintenance of the abnormal pain associated with chronic neuropathic pain. It remains unclear how stress-induced analgesia is affected by neuropathic pain states. We therefore examined the impact of a chronic constriction nerve-injury (CCI) model of neuropathic pain on restraint stress-induced analgesia in C57BL/6 mice. Thirty minutes of restraint stress produced analgesia in the hotplate thermal nociceptive assay that was less in CCI compared to control mice who underwent a sham-surgery. In sham but not CCI mice, stress-induced analgesia was reduced by the opioid receptor antagonist naltrexone. The cannabinoid CB1 receptor antagonist AM281 did not affect stress-induced analgesia in either sham or CCI mice. Low-dose pre-treatment with the dual fatty acid amide hydrolase and monoacylglycerol lipase inhibitor JZL195 increased stress-induced analgesia in CCI but not sham mice. The JZL195 enhancement of stress-induced analgesia in CCI mice was abolished by AM281 but was unaffected by naltrexone. These findings indicate that the acute opioid-mediated analgesic response to a psychological stressor is disrupted in a nerve-injury model of neuropathic pain. Importantly, this impairment of stress-induced analgesia was rescued by blockade of endocannabinoid breakdown via a cannabinoid CB1 receptor dependent mechanism. These findings suggest that subthreshold treatment with endocannabinoid degradation blockers could be used to alleviate the disruption of endogenous pain control systems in a neuropathic pain state. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22analgesia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">analgesia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cannabinoid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cannabinoid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endogenous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endogenous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuropathic+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuropathic pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">stress</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuralgia%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuralgia/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuralgia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuralgia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoids/metabolism</a></li><li><a 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id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Chagas LA</b>, Penna J, Gonçalves JF, Elias L, Antunes-Rodrigues J, Ruginsk SG. Acute rimonabant treatment prevents anhedonia and memory loss in rats submitted to mild restraint stress. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2024;<b>474</b>:115175. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39098399' target='_blank'>39098399</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115175' target='_blank'>10.1016/j.bbr.2024.115175</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115175','39098399', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115175' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.bbr.2024.115175" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Stress-related disorders are becoming increasingly common and are often associated with cognitive impairments. Within this context, the endocannabinoid (ECB) system, particularly the type 1 cannabinoid (CB1) receptor, seems to play a decisive role in restoring body homeostasis. There is consistent evidence in the literature that disrupted CB1-mediated neurotransmission can ultimately contribute to stress-related diseases. Therefore, the present study aimed to evaluate the participation of CB1 receptors in the integrity of stress-induced peripheral and behavioral responses. For this purpose, male adult Wistar rats underwent physical restraint (1 h/day, for 7 days), followed by a single administration of rimonabant (CB1 receptor antagonist, 3 mg/Kg, intraperitonial) at the end of stress protocol. Animals were then subjected to evaluation of neuroendocrine responses, behavioral tests and quantification of Iba-1 (microglial) immunoreactivity in the parvocellular subdivisions of the paraventricular nucleus of the hypothalamus (PVN). No effects of restraint stress or rimonabant administration were detected on body mass variation. However, stress significantly increased adrenal relative mass and corticosterone secretion, and reduced thymus relative size. The stress effects on adrenal size and corticosterone plasma levels were absent in rimonabant-treated rats, but the thymus size was further reduced in the restraint-rimonabant group. Restraint stress also induced anhedonia, a depression-like behavior, and reduced object recognition index, indicating memory recovery impairment. Treatment with the CB1 antagonist significantly reversed stress-induced anhedonia and memory deficit. In the PVN, restraint stress reduced the number of Iba-1 positive cells in the medial parvocellular region of vehicle- but not rimonabant-treated animals. Taken together, these results indicate that the acute inhibition of the CB1-mediated endogenous pathway restores stress-induced depression-like behaviors and memory loss, suggesting a role for endocannabinoids in the neuro-immune-endocrine interplay at both peripheral and hypothalamic levels. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB1+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB1 receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoid+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoid system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Restraint+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Restraint stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rimonabant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rimonabant</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Paraventricular+Hypothalamic+Nucleus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Paraventricular Hypothalamic Nucleus/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piperidines%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piperidines/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyrazoles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyrazoles/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Dalle S</b>, Schouten M, Deboutte J, de Lange E, Ramaekers M, Koppo K. The molecular signature of the peripheral cannabinoid receptor 1 antagonist AM6545 in adipose, liver and muscle tissue. <em class='incite-journal-name' onclick='ShowInCiteJournal(22824);'>Toxicol Appl Pharmacol</em> 2024;<b>491</b>:117081. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39216835' target='_blank'>39216835</a> DOI: <a href='https://dx.doi.org/10.1016/j.taap.2024.117081' target='_blank'>10.1016/j.taap.2024.117081</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.taap.2024.117081','39216835', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.taap.2024.117081' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22824);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.taap.2024.117081" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The endocannabinoid system plays an important role in the regulation of metabolism, growth and regeneration of peripheral tissues, including liver, adipose and muscle tissue. Studies in cells, rodents and humans showed that cannabinoid receptor 1 (CB1) antagonist treatment is an effective strategy to improve features of metabolic health such as substrate metabolism, at least in models of metabolic dysregulation. However, acute signaling events that might induce these metabolic adaptations are not understood. It is not clear whether, and to which extent, a single treatment with a CB1 antagonist induces acute effects in peripheral, metabolic tissues. Therefore, the present study compared the phosphorylation status of signaling pathways and metabolic markers in liver, adipose and muscle tissue of mice treated with the peripherally restricted CB1 antagonist AM6545 and vehicle-treated mice. Protein kinase A phosphorylation was downregulated in white and brown adipose tissue, whereas the mitogen-activated protein kinase, phospho-extracellular signal-regulated kinase, was higher in liver, white adipose and muscle tissue of AM6545-treated mice. Additionally, Akt-mammalian target of rapamycin activation was higher in all tissues of AM6545-treated mice, whereas the phosphorylation status of metabolic markers remained unaffected. These data indicate that acute CB1 antagonism is effective to induce phosphorylation events of signaling cascades and metabolic markers in metabolic tissues of healthy, lean mice within a 90-min time window. The observed adaptations to AM6545 treatment do not fully align with earlier in vitro and in vivo findings, which could be ascribed to differences in cell type, exposure intensity (dose and time), health status and species. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AM6545%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AM6545</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoid+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoid receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22G+protein-coupled+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">G protein-coupled receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitogen-activated+protein+kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitogen-activated protein kinases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+kinase+A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein kinase A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mTOR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mTOR</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Skeletal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Skeletal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Skeletal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Skeletal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyrazoles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyrazoles/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Cooper ME</b>, Nørregaard PK, Högberg T, Andersson G, Receveur JM, Linget JM, Elling CE. Efficacy in diet-induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837. <em class='incite-journal-name' onclick='ShowInCiteJournal(4298);'>Br J Pharmacol</em> 2024;<b>181</b>:3926-3943. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38886096' target='_blank'>38886096</a> DOI: <a href='https://dx.doi.org/10.1111/bph.16401' target='_blank'>10.1111/bph.16401</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/bph.16401','38886096', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/bph.16401' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4298);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/20/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1111/bph.16401" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND PURPOSE</div><div class="abstract-content">The cannabinoid CB1 receptor has a well-established role in appetite regulation. Drugs antagonizing central CB1 receptors, most notably rimonabant, induced weight loss and improved the metabolic profile in obese individuals but were discontinued due to psychiatric side effects. However, metabolic benefits were only partially attributable to weight loss, implying a role for peripheral receptors, and peripherally restricted CB1 receptor antagonists have since been of interest. Herein, we describe the evaluation of the peripherally restricted potent CB1 receptor inverse agonists TM38837 and TM39875, with acidic functionality, which were administered daily to diet-induced obese (DIO) mice for 5 weeks at doses for which CNS-mediated effects were minimal. </div><div class="abstract-label">EXPERIMENTAL APPROACH</div><div class="abstract-content">Compounds were tested in dose-response in acute studies to compare efficacy (gastric transport) and extent of CNS exposure (hypothermia and satiety sequence) to demonstrate peripheral restriction and select doses for the subsequent chronic DIO study. </div><div class="abstract-label">KEY RESULTS</div><div class="abstract-content">TM38837 but not TM39875 produced considerable (26%) weight loss, linked to a sustained reduction in food intake, together with improvements in plasma markers of inflammation and glucose homeostasis. Pharmacokinetic analysis indicated high plasma and low brain levels for both compounds with high liver levels for TM38837 (but not TM39875) due to hepatic uptake. </div><div class="abstract-label">CONCLUSION AND IMPLICATIONS</div><div class="abstract-content">Weight loss and metabolic benefits of TM38837 are likely not CNS-mediated but could be linked to enhanced liver exposure, which implicates intracellular CB1 receptors in hepatocytes as a possible driver of obesity and co-morbidities. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB1+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB1 receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TM38837%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TM38837</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hepatocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hepatocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inverse+agonist%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inverse agonist</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver+targeted%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver targeted</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">obesity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22peripherally+restricted%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">peripherally restricted</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dose-Response+Relationship%2c+Drug%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dose-Response Relationship, Drug</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Inverse+Agonism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Inverse Agonism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eating%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eating/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Obese%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Obese</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Kurtov M</b>, Rubinić I, Likić R. The endocannabinoid system in appetite regulation and treatment of obesity. <em class='incite-journal-name' onclick='ShowInCiteJournal(158154);'>Pharmacol Res Perspect</em> 2024;<b>12</b>:e70009. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39292202' target='_blank'>39292202</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409765' target='_blank'>PMC11409765</a> DOI: <a href='https://dx.doi.org/10.1002/prp2.70009' target='_blank'>10.1002/prp2.70009</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/prp2.70009','39292202', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(158154);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1002/prp2.70009" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The endocannabinoid system (ECS) is a complex cell-signaling system that is responsible for maintaining homeostasis by modulating various regulatory reactions in response to internal and environmental changes. The influence of ECS on appetite regulation has been a subject of much recent research, however, the full extent of its impact remains unknown. Current evidence links human obesity to ECS activation, increased endocannabinoid levels in both central and peripheral tissues, along with cannabinoid receptor type 1 (CBR1) up-regulation. These findings imply the potential pharmacological use of the ECS in the treatment of obesity. Here, we present various pathophysiological processes in obesity involving the ECS, highlighting different pharmacological options for modulating endocannabinoid activity to treat obesity. However, the potential of those pharmacological possibilities remains under investigation and requires further research. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocannabinoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocannabinoids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Appetite+Regulation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Appetite Regulation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Obesity+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Obesity Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Obesity+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Obesity Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Soler-Cedeño O</b>, Alton H, Bi GH, Linz E, Ji L, Makriyannis A, Xi ZX. AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects. <em class='incite-journal-name' onclick='ShowInCiteJournal(17746);'>Neuropsychopharmacology</em> 2024;<b>49</b>:1678-1688. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38600154' target='_blank'>38600154</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399149' target='_blank'>PMC11399149</a> DOI: <a href='https://dx.doi.org/10.1038/s41386-024-01861-y' target='_blank'>10.1038/s41386-024-01861-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41386-024-01861-y','38600154', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41386-024-01861-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17746);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mts-npp.nature.com/cgi-bin/main.plex' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1038/s41386-024-01861-y" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Preclinical research has demonstrated the efficacy of CB1 receptor (CB1R) antagonists in reducing drug-taking behavior. However, clinical trials with rimonabant, a CB1R antagonist with inverse agonist profile, failed due to severe adverse effects, such as depression and suicidality. As a result, efforts have shifted towards developing novel neutral CB1R antagonists without an inverse agonist profile for treating substance use disorders. Here, we assessed AM6527, a CB1R neutral antagonist, in addiction animal models. Our findings revealed that AM6527 did not affect cocaine self-administration under fixed-ratio reinforcement schedules but dose-dependently inhibited it under progressive-ratio reinforcement schedules. Additionally, AM6527 dose-dependently inhibited heroin self-administration under both fixed-ratio and progressive-ratio reinforcement schedules and oral sucrose self-administration under a fixed-ratio reinforcement schedule, as well as cocaine- or heroin-triggered reinstatement of drug-seeking behavior in rats. However, chronic AM6527 administration for five consecutive days significantly inhibited heroin self-administration only during the initial two days, indicating tolerance development. Notably, AM6527 did not produce rewarding or aversive effects by itself in classical electrical intracranial self-stimulation and conditioned place preference tests. However, in optical intracranial self-stimulation (oICSS) maintained by optogenetic stimulation of midbrain dopamine neurons in DAT-cre mice, both AM6527 and rimonabant dose-dependently inhibited dopamine-dependent oICSS behavior. Together, these findings suggest that AM6527 effectively reduces drug-taking and seeking behaviors without rimonabant-like adverse effects. Thus, AM6527 warrants further investigation as a potential pharmacotherapy for opioid and cocaine use disorders. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a 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HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZIA DA000633 Intramural NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26+Human+Services+%7c+NIH+%7c+National+Institute+on+Drug+Abuse+(NIDA)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01DA023142-01 U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26+Human+Services+%7c+NIH+%7c+National+Institute+on+Drug+Abuse+(NIDA)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZIA-DA000633 U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Cosentino L</b>, Urbinati C, Lanzillotta C, De Rasmo D, Valenti D, Pellas M, Quattrini MC, Piscitelli F, Kostrzewa M, Di Domenico F, Pietraforte D, Bisogno T, Signorile A, Vacca RA, De Filippis B. Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome. <em class='incite-journal-name' onclick='ShowInCiteJournal(17387);'>Mol Autism</em> 2024;<b>15</b>:39. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39300547' target='_blank'>39300547</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414047' target='_blank'>PMC11414047</a> DOI: <a href='https://dx.doi.org/10.1186/s13229-024-00617-1' target='_blank'>10.1186/s13229-024-00617-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13229-024-00617-1','39300547', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13229-024-00617-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17387);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1186/s13229-024-00617-1" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett syndrome (RTT), a rare neurologic disorder that severely affects mainly females carrying mutations in the X-linked MECP2 gene. A pool of CB1 cannabinoid receptors (CB1R), the primary receptor subtype of the endocannabinoid system in the brain, is located on brain mitochondrial membranes (mtCB1R), where it can locally regulate energy production, synaptic transmission and memory abilities through the inhibition of the intra-mitochondrial protein kinase A (mtPKA). In the present study, we asked whether an overactive mtCB1R-mtPKA signaling might underlie the brain mitochondrial alterations in RTT and whether its modulation by systemic administration of the CB1R inverse agonist rimonabant might improve bioenergetics and cognitive defects in mice modeling RTT. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Rimonabant (0.3 mg/kg/day, intraperitoneal injections) was administered daily to symptomatic female mice carrying a truncating mutation of the Mecp2 gene and its effects on brain mitochondria functionality, systemic oxidative status, and memory function were assessed. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">mtCB1R is overexpressed in the RTT mouse brain. Subchronic treatment with rimonabant normalizes mtCB1R expression in RTT mouse brains, boosts mtPKA signaling, and restores the defective brain mitochondrial bioenergetics, abnormal peripheral redox homeostasis, and impaired cognitive abilities in RTT mice. </div><div class="abstract-label">LIMITATIONS</div><div class="abstract-content">The lack of selectivity of the rimonabant treatment towards mtCB1R does not allow us to exclude that the beneficial effects exerted by the treatment in the RTT mouse model may be ascribed more broadly to the modulation of CB1R activity and distribution among intracellular compartments, rather than to a selective effect on mtCB1R-mediated signaling. The low sample size of few experiments is a further limitation that has been addressed replicating the main findings under different experimental conditions. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">The present data identify mtCB1R overexpression as a novel molecular alteration in the RTT mouse brain that may underlie defective brain mitochondrial bioenergetics and cognitive dysfunction. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain mitochondria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB1+cannabinoid+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB1 cannabinoid receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Energy+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Energy metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intellectual+disability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intellectual disability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouse+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouse model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PKA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PKA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rett+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rett syndrome</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; 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text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Thomsen LR</b>, Glass M, Rosengren RJ. The impact of piperazine and antipsychotic co-exposures and CB1 blockade on the effects elicited by AMB-FUBINACA, a synthetic cannabinoid, in mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(8802);'>Eur J Pharmacol</em> 2024;<b>979</b>:176844. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39053868' target='_blank'>39053868</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejphar.2024.176844' target='_blank'>10.1016/j.ejphar.2024.176844</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejphar.2024.176844','39053868', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ejphar.2024.176844' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8802);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.ejphar.2024.176844" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND & PURPOSE</div><div class="abstract-content">The constant emergence and broad toxicological effects of synthetic cannabinoids create a discernible public health threat. The synthetic cannabinoid AMB-FUBINACA (AMB-FUB) is a potent agonist at the CB1 receptor and has been associated with numerous fatalities. Synthetic cannabinoids are commonly abused alongside other drugs and medications, including a "party pill" drug, para-fluorophenylpiperazine (pFPP), and the antipsychotic risperidone. This research aimed to investigate the mechanisms underpinning AMB-FUB toxicity and the impact of clinically relevant co-exposures in vivo. </div><div class="abstract-label">EXPERIMENTAL APPROACH</div><div class="abstract-content">Male and female C57Bl/6 mice received a single dose of AMB-FUB (3 or 6 mg kg-1), pFPP (10 or 20 mg kg-1) or vehicle intraperitoneally. Mice were co-exposed to AMB-FUB (3 mg kg-1) and pFPP (10 mg kg-1) or risperidone (0.5 mg kg-1) to investigate these drug combinations. To study receptor-dependency and potential rescue of AMB-FUB toxicity, rimonabant (3 mg kg-1) was administered both pre- and post-AMB-FUB. Adverse effects caused by drug administration, including hypothermia and convulsions, were recorded. </div><div class="abstract-label">KEY RESULTS</div><div class="abstract-content">AMB-FUB induced CB1-dependent hypothermia and convulsions in mice. The combination of AMB-FUB and pFPP significantly potentiated hypothermia, as did risperidone pre-treatment. Interestingly, risperidone provided significant protection from AMB-FUB-induced convulsions in female mice. Pre- and post-treatment with rimonabant was able to significantly attenuate both hypothermia and convulsions in mice administered AMB-FUB. </div><div class="abstract-label">CONCLUSION & IMPLICATIONS</div><div class="abstract-content">Factors such as dose, CB1 signalling, and substance co-exposure significantly contribute to the toxicity of AMB-FUBINACA. Mechanistic understanding of synthetic cannabinoid toxicity and fatality can help inform overdose treatment strategies and identify vulnerable populations of synthetic cannabinoid users. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMB-FUBINACA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMB-FUBINACA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Co-exposure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Co-exposure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22In+vivo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">In vivo</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synthetic+cannabinoid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synthetic cannabinoid</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipsychotic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipsychotic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipsychotic+Agents%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipsychotic Agents/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipsychotic+Agents%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipsychotic Agents/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piperazines%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piperazines/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risperidone%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risperidone/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piperazine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piperazine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rimonabant%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rimonabant/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Aguirre-Rodríguez CA</b>, Delgado A, Alatorre A, Oviedo-Chávez A, Martínez-Escudero JR, Barrientos R, Querejeta E. Local activation of CB1 receptors by synthetic and endogenous cannabinoids dampens burst firing mode of reticular thalamic nucleus neurons in rats under ketamine anesthesia. <em class='incite-journal-name' onclick='ShowInCiteJournal(9165);'>Exp Brain Res</em> 2024;<b>242</b>:2137-2157. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38980339' target='_blank'>38980339</a> DOI: <a href='https://dx.doi.org/10.1007/s00221-024-06889-6' target='_blank'>10.1007/s00221-024-06889-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00221-024-06889-6','38980339', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00221-024-06889-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9165);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1007/s00221-024-06889-6" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The reticular thalamic nucleus (RTN) is a thin shell that covers the dorsal thalamus and controls the overall information flow from the thalamus to the cerebral cortex through GABAergic projections that contact thalamo-cortical neurons (TC). RTN neurons receive glutamatergic afferents fibers from neurons of the sixth layer of the cerebral cortex and from TC collaterals. The firing mode of RTN neurons facilitates the generation of sleep-wake cycles; a tonic mode or desynchronized mode occurs during wake and REM sleep and a burst-firing mode or synchronized mode is associated with deep sleep. Despite the presence of cannabinoid receptors CB1 (CB1Rs) and mRNA that encodes these receptors in RTN neurons, there are few works that have analyzed the participation of endocannabinoid-mediated transmission on the electrical activity of RTN. Here, we locally blocked or activated CB1Rs in ketamine anesthetized rats to analyze the spontaneous extracellular spiking activity of RTN neurons. Our results show the presence of a tonic endocannabinoid input, since local infusion of AM 251, an antagonist/inverse agonist, modifies RTN neurons electrical activity; furthermore, local activation of CB1Rs by anandamide or WIN 55212-2 produces heterogeneous effects in the basal spontaneous spiking activity, where the main effect is an increase in the spiking rate accompanied by a decrease in bursting activity in a dose-dependent manner; this effect is inhibited by AM 251. In addition, previous activation of GABA-A receptors suppresses the effects of CB1Rs on reticular neurons. Our results show that local activation of CB1Rs primarily diminishes the burst firing mode of RTn neurons. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Burst+firing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Burst firing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CB1+receptors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB1 receptors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endogenous+cannabinoids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endogenous cannabinoids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reticular+thalamic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reticular thalamic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thalamo-cortical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thalamo-cortical</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a 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id="citation22" class="article-citation"> <b>McFadden MH</b>, Emeritt MB, Xu H, Cui Y, Leterrier C, Zala D, Venance L, Lenkei Z. Actomyosin-mediated inhibition of synaptic vesicle release under CB<sub>1</sub>R activation. <em class='incite-journal-name' onclick='ShowInCiteJournal(22922);'>Transl Psychiatry</em> 2024;<b>14</b>:335. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39168993' target='_blank'>39168993</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339458' target='_blank'>PMC11339458</a> DOI: <a href='https://dx.doi.org/10.1038/s41398-024-03017-4' target='_blank'>10.1038/s41398-024-03017-4</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41398-024-03017-4','39168993', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41398-024-03017-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22922);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mts-tp.nature.com/cgi-bin/main.plex' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/23/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1038/s41398-024-03017-4" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Long-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic mechanisms of functional plasticity remain poorly understood. Here, we show that changes in synaptic efficacy induced by activation of the cannabinoid type-1 receptor (CB1R), one of the most widespread G-protein coupled receptors in the brain, requires contractility of the neuronal actomyosin cytoskeleton. Specifically, using a synaptophysin-pHluorin probe (sypH2), we show that inhibitors of non-muscle myosin II (NMII) ATPase as well as one of its upstream effectors Rho-associated kinase (ROCK) prevent the reduction of synaptic vesicle release induced by CB1R activation. Using 3D STORM super-resolution microscopy, we find that activation of CB1R induces a redistribution of synaptic vesicles within presynaptic boutons in an actomyosin dependent manner, leading to vesicle clustering within the bouton and depletion of synaptic vesicles from the active zone. We further show, using sypH2, that inhibitors of NMII and ROCK specifically restore the release of the readily releasable pool of synaptic vesicles from the inhibition induced by CB1R activation. Finally, using slice electrophysiology, we find that activation of both NMII and ROCK is necessary for the long-term, but not the short-term, form of CB1R induced synaptic plasticity at excitatory cortico-striatal synapses. We thus propose a novel mechanism underlying CB1R-induced plasticity, whereby CB1R activation leads to a contraction of the actomyosin cytoskeleton inducing a reorganization of the functional presynaptic vesicle pool, preventing vesicle release and inducing long-term depression. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular+neuroscience%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular neuroscience</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22long-term+memory%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">long-term memory</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synaptic+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synaptic Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synaptic+Vesicles%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synaptic Vesicles/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Actomyosin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Actomyosin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rho-Associated+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rho-Associated Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuronal+Plasticity%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuronal Plasticity/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuronal+Plasticity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuronal Plasticity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Presynaptic+Terminals%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Presynaptic Terminals/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Presynaptic+Terminals%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Presynaptic Terminals/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myosin+Type+II%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myosin Type II/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Diester CM</b>, Balint H, Gillespie JC, Lichtman AH, Sim-Selley LJ, Selley DE, Negus SS. Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(15211);'>J Pharmacol Exp Ther</em> 2024;<b>390</b>:291-301. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38262742' target='_blank'>38262742</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338278' target='_blank'>PMC11338278</a> DOI: <a href='https://dx.doi.org/10.1124/jpet.123.001940' target='_blank'>10.1124/jpet.123.001940</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1124/jpet.123.001940','38262742', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1124/jpet.123.001940' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(15211);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/25/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1124/jpet.123.001940" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">MJN110 inhibits the enzyme monoacylglycerol lipase (MAGL) to increase levels of the endocannabinoid 2-arachidonoylglycerol , an endogenous high-efficacy agonist of cannabinoid 1 and 2 receptors (CB1/2R). MAGL inhibitors are under consideration as candidate analgesics, and we reported previously that acute MJN110 produced partial antinociception in an assay of pain-related behavioral depression in mice. Given the need for repeated analgesic administration in many pain patients and the potential for analgesic tolerance during repeated treatment, this study examined antinociceptive effects of repeated MJN110 on pain-related behavioral depression and CB1R-mediated G-protein function. Male and female ICR mice were treated daily for 7 days in a 2 × 2 design with (a) 1.0 mg/kg/d MJN110 or its vehicle followed by (b) intraperitoneal injection of dilute lactic acid (IP acid) or its vehicle as a visceral noxious stimulus to depress nesting behavior. After behavioral testing, G-protein activity was assessed in lumbar spinal cord (LSC) and five brain regions using an assay of CP55,940-stimulated [35S]GTPɣS activation. As reported previously, acute MJN110 produced partial but significant relief of IP acid-induced nesting depression on day 1. After 7 days, MJN110 continued to produce significant but partial antinociception in males, while antinociceptive tolerance developed in females. Repeated MJN110 also produced modest decreases in maximum levels of CP55,940-induced [35S]GTPɣS binding in spinal cord and most brain regions. These results indicate that repeated treatment with a relatively low antinociceptive MJN110 dose produces only partial and sex-dependent transient antinociception associated with the emergence of CB1R desensitization in this model of IP acid-induced nesting depression. SIGNIFICANCE STATEMENT: The drug MJN110 inhibits monoacylglycerol lipase (MAGL) to increase levels of the endogenous cannabinoid 2-arachidonoylglycerol and produce potentially useful therapeutic effects including analgesia. This study used an assay of pain-related behavioral depression in mice to show that repeated MJN110 treatment produced (1) weak but sustained antinociception in male mice, (2) antinociceptive tolerance in females, and (3) modest cannabinoid-receptor desensitization that varied by region and sex. Antinociceptive tolerance may limit the utility of MJN110 for treatment of pain. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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Postnatal hypofunction of N-methyl-D-aspartate receptors alters perforant path synaptic plasticity and filtering and impairs dentate gyrus-mediated spatial discrimination. <em class='incite-journal-name' onclick='ShowInCiteJournal(4298);'>Br J Pharmacol</em> 2024;<b>181</b>:2701-2724. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38631821' target='_blank'>38631821</a> DOI: <a href='https://dx.doi.org/10.1111/bph.16375' target='_blank'>10.1111/bph.16375</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/bph.16375','38631821', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/bph.16375' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4298);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1111/bph.16375" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND PURPOSE</div><div class="abstract-content">Transient hypofunction of the NMDA receptor represents a convergence point for the onset and further development of psychiatric disorders, including schizophrenia. Although the cumulative evidence indicates dysregulation of the hippocampal formation in schizophrenia, the integrity of the synaptic transmission and plasticity conveyed by the somatosensorial inputs to the dentate gyrus, the perforant pathway synapses, have barely been explored in this pathological condition. </div><div class="abstract-label">EXPERIMENTAL APPROACH</div><div class="abstract-content">We identified a series of synaptic alterations of the lateral and medial perforant paths in animals postnatally treated with the NMDA antagonist MK-801. This dysregulation suggests decreased cognitive performance, for which the dentate gyrus is critical. </div><div class="abstract-label">KEY RESULTS</div><div class="abstract-content">We identified alterations in the synaptic properties of the lateral and medial perforant paths to the dentate gyrus synapses in slices from MK-801-treated animals. Altered glutamate release and decreased synaptic strength precede an impairment in the induction and expression of long-term potentiation (LTP) and CB1 receptor-mediated long-term depression (LTD). Remarkably, by inhibiting the degradation of 2-arachidonoylglycerol (2-AG), an endogenous ligand of the CB1 receptor, we restored the LTD in animals treated with MK-801. Additionally, we showed for the first time, that spatial discrimination, a cognitive task that requires dentate gyrus integrity, is impaired in animals exposed to transient hypofunction of NMDA receptors. </div><div class="abstract-label">CONCLUSION AND IMPLICATIONS</div><div class="abstract-content">Dysregulation of glutamatergic transmission and synaptic plasticity from the entorhinal cortex to the dentate gyrus has been demonstrated, which may explain the cellular dysregulations underlying the altered cognitive processing in the dentate gyrus associated with schizophrenia. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAGL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAGL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MK%e2%80%90801%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MK‐801</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cannabinoid+receptor+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cannabinoid receptor 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dentate+gyrus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dentate gyrus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22perforant+path%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">perforant path</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22schizophrenia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">schizophrenia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22spatial+discrimination%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">spatial discrimination</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+N-Methyl-D-Aspartate%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+N-Methyl-D-Aspartate%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, N-Methyl-D-Aspartate/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dentate+Gyrus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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<b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CONAHCyT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">725800 CONAHCyT</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Haghdoost M</b>, Young S, Holloway AK, Roberts M, Zvorsky I, Bonn-Miller MO. CBD Versus CBDP: Comparing In Vitro Receptor-Binding Activities. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:7724. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39062976' target='_blank'>39062976</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11277192' target='_blank'>PMC11277192</a> DOI: <a href='https://dx.doi.org/10.3390/ijms25147724' target='_blank'>10.3390/ijms25147724</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms25147724','39062976', 'Receptor, Cannabinoid, CB1/antagonists & inhibitors')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms25147724' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.3390/ijms25147724" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Phytocannabinoids with seven-carbon alkyl chains (phorols) have gained a lot of attention, as they are commonly believed to be more potent versions of typical cannabinoids with shorter alkyl chains. At the time of this article, cannabidiphorol (CBDP) and tetrahydrocannabiphorol (THCP) can both be purchased in the North American market, even though their biological activities are nearly unknown. To investigate their relative potency, we conducted in vitro receptor-binding experiments with CBDP (cannabinoid CB1/CB2 receptor antagonism, serotonin 5HT-1A agonism, dopamine D2S (short form) agonism, and mu-opioid negative allosteric modulation) and compared the observed activity with that of CBD. To our knowledge, this is the first publication to investigate CBDP's receptor activity in vitro. A similar activity profile was observed for both CBD and CBDP, with the only notable difference at the CB2 receptor. Contrary to common expectations, CBD was found to be a slightly more potent CB2 antagonist than CBDP (p < 0.05). At the highest tested concentration, CBD demonstrated antagonist activity with a 33% maximum response of SR144528 (selective CB2 antagonist/inverse agonist). CBDP at the same concentration produced a weaker antagonist activity. A radioligand binding assay revealed that among cannabinoid and serotonin receptors, CB2 is likely the main biological target of CBDP. However, both CBD and CBDP were found to be significantly less potent than SR144528. The interaction of CBDP with the mu-opioid receptor (MOR) produced unexpected results. Although the cannabidiol family is considered to be a set of negative allosteric modulators (NAMs) of opioid receptors, we observed a significant increase in met-enkephalin-induced mu-opioid internalization when cells were incubated with 3 µM of CBDP and 1 µM met-enkephalin, a type of activity expected from positive allosteric modulators (PAMs). To provide a structural explanation for the observed PAM effect, we conducted molecular docking simulations. These simulations revealed the co-binding potential of CBDP (or CBD) and met-enkephalin to the MOR. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22agonist%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">agonist</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antagonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cannabidiol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cannabidiol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cannabidiphorol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cannabidiphorol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cannabinoid+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cannabinoid receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Opioid%2c+mu%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Opioid, mu/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Opioid%2c+mu%2fagonists%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Opioid, mu/agonists</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Cannabinoid%2c+CB1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Cannabinoid, CB1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Binding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Binding</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cannabinoids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cannabinoids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Receptor, Cannabinoid, CB1/antagonists & inhibitors (859 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Receptor, Cannabinoid, CB1/antagonists & inhibitors (859 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>