CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '8e7f5dc77ee344bb',cH: 'oi69e0LOeLb5ZYG2VvxCmF64et7F7MPgqBi6kSYO2Gw-1732513880-1.2.1.1-HdHmc_SlU6gUlIQM3hXYsTsSDnntjPuEDK.mDb6v1Gl2KzihQrzRM3ej97CNwq2Q',cUPMDTk: "\/doi\/10.1021\/ja8053805?__cf_chl_tk=5P15G7ehAP7HdXu_LObopay0jJJhYEpS57h5CqAgAJ4-1732513880-1.0.1.1-0nrl_3_tp1aO4mFFVLlvFMAa007ovZdL51AqDj4qRvE",cFPWv: 'g',cITimeS: '1732513880',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/ja8053805?__cf_chl_f_tk=5P15G7ehAP7HdXu_LObopay0jJJhYEpS57h5CqAgAJ4-1732513880-1.0.1.1-0nrl_3_tp1aO4mFFVLlvFMAa007ovZdL51AqDj4qRvE",md: "TCmr8PH3SUlWJNAQ3KIXZ2i6WAOxm1AZBMcvYdzRe4Q-1732513880-1.2.1.1-eB5i.9YOQFEpMjb6X3Bc16NTd4wm2jjrvDNj.4NGj_CQ.guICPpV_.NOCH7CfCeWU9HRNT0sVa7QwpE26_TWfqGJGdvzIMu4CqYmBdaM9yqyldDiwbvOE2v8glpwfn98k2c.EfJy0o0K_qR3l7Tye7lMV0auzvduMooEmoMT1cq.0Yomfl1quoQ3JCH2Y1c7aOUAw7KTKfHkVSJN4EvMHvvgvpTy2cIuzBz_EGTb90wq90jVSUHeNsBIVrawFPrqYLCgM_1JwUD5tP0R0a8sGu3NneONzNHru3jpUEje.VtzFjOqDGtzcvUZLxPtQHkio1JLks8zvXT2gfTnkUv9memZVo29jDXsfxRXHuw2_yeViByugmy_BHGc51HaUZBf1zlXwVqEodpBo0BzAXII1gLZdrbsqz_zmfWYwoi9T_PmOS.qrM4O6EryU9kLAdLMdMJuZYbN.LlSkOrA6dxgRk5Nt6eg67IYdk3EHU9A8HilQea8QbYaZRwLKfdIhW1ZcRTULtyah2zicxde_J6RJhwkOp8tfmGKvmjXD3gcwYnFB8CHFe1Xji3ycikKV2tLJIyiWDx9U8AYc3C8nhm5NsRVYa5MZRBu3NYfkQ_jTshsZtouh.n9ViEKTben1oXdZV9xy2QEmk.MikLjVWxzYMNXgyoKSB0Crk8zltOGUQFBr4CvbGW8sCJSMOxG4mRMV.vmsYDRUaK07EZJpXiLO7Lqt32MTF_6LtwHP.VZG1_LXIfSCF8gOZGEnlm.30fYgjrrT6y9jmJGHYGDRigZ8KsOFb3X6NWa67ujV1HGUJsff.PjHuIN.NR8M3Ex.phi8mv8NRRqFNQX8RQDeXkbV7iWJuycEb_mS2XCf0of._D8OHiPpLdQcW6dmUipRcTvivDnThZCYXyTxDZ5LPwiqFDJSfd_6NJcru1HfSmew7WJKH2JQWfmLfHfZvYxDdrxwHYtmyrvA1NfQZmWQLLp6TWVXqzZQoo7B1AvahWEQQtRvAw9uu0o4f7bkP3JLooE2CApj84KnnU5VJas0sVPzOqsd3W3HsHJzA1tczEJf2WonZbAgTYCYtcijNAJvRnwLMMzXg0iA07oMs90ehd9s2ojj9937sLGcZPM3Q2pSt3Dva3HduPe.ZTBq7CwnNq3a7I1mhGMBiOaW0Y4u6PB9MrpMKtsn81UzTyngwcJIHQQcYZ3Bt_xtkQHCSBwlGVfsvpcOQvAu0.l042pGW9XikdW3ieVV58k2N82AhI_XNuRxefDc3ttNZGoZHU5LZkwSk_fUmkIEQxG8g_rCZfmvxOP3tq2yue04qRGTEehyqNnYuo3Af_eY0GZIpwXecfK9FQ.Y00BCgAjvMfmlnBqDNc09_qH0IlUy_vnYG8qL4kmiBiqSLrC0M0i0VrINhE2CRIe11ZKga7wfcRHyORkoY8sWKkEdlcFQ29_fbrwtY2agk28T7RpyNJeYfMaitf29fDMZW9McA9jIAXfXLKoC3bY.bwyMazzj8aC2NJL1MsPqiV9hMbl6QyiaRX5BoYvrfyh3UimIrB4ayiX5mi4WaHyS8utsup2Ci8JF25hrCu6_29Cc19KTUL8TBYq8oRwGMZSZxnBOSx5deM1VSj8rGtoNSP5WPPLHtBa6K7WPwrW5J.k8I6JHdJGbnhhBYUM0RYGOWKwzpZHOGBrziKhf5p9_r2YauNfFV3hCpUe13S2yhpEMWgel16yC0C7VvCpbQh2R4GoD1p8am6rHgnHpUVDai05zp1GkUuXQlN4iIq_3Y1M7A9bBRe.hajlm.hMeFsYkDB0DAYq0kgXeg9Wlz6vyf17D9ZFAbcIiG0TvFzSAk5VWN5NHM_RombaXpYa6SMADlr3dxyA8kOPWT3TGS.qDAYU1Yv9Sj0HAMQ8F.gttMHb9ibmi4T4IToXaq.xktHYupdqOjNFDlsPMKnMIdWMXa43WEW5ne0vBUwdV.Wog1WOu.izJ8Pja.jjLkvA5xw0Ix6NPlC126EUE..YdobhgSS_0O6815rmDXwBEIsG7ySB1eEuRMJ1rBvivJR4CNvSd8.Ia79fwMvm8A16JTzZpHviuTexmltLCsAaI7EfBqw7ThOYOl2v3XDnYyjgftnKJABkGuthMlTr90hrJM.4.D8GfUCXi_6w4I0ww4upR_mxiS54Z6Bykeq.o7RiQEUEUZs0t7DiIN01db_KPz_ZZKGkVXhzFYhBsi92SIN54bwpBR7hs45g4RpdKLUpZq0lgKOAS_39jfD.uNVReDimgdeRhPemeMhn2aXSHNXPk05iYE89GT4XR7pq8rfhyOna9B1HX4rxonX9hcQ3N9dYZvYCUqK.azGr7i3zrG7ItgU1LwDz1nFL7xkrKPnnOAMhpUxQOaLBzpieeEdR1YgSE0bHGjjY6.B1b8QGAR8BO3cUsLh7rkD7aO1AIOKtOomool1pD9MFPAKOq_3U9q6yjWsB1cQW4az2nl7kX1Vgq3IQ5LEy4VW2slZwjhwrFyMqAjGLDRdsriIS6Ofg.Raqbz2W7EM6Qa9.9h34snDraQalmtZH9CR1VWLi6z4oKCe.O8sFjUuPTnIv0J30uZyWzYqICN20d0atl_xaVwwaz.kwpdDriZrEgn24E21gOvLzc.2oki0gMvRSwvsFBXvzI1qKbuOMMcEStTL1SRnF1j.Bjr1z50XlxhnicCp_g4Cfgdg1tmsWz3I5wCJfIiCzI0NE4eBie_.LI8BvuZ8Asdkzrd8_PdaWrJdBJCi1MY3KN.CaBqsfLE5ikT3TLYYsDr.A1OczUKzDaDsJ4LEb.c8yevdo2Xz64fhPhX0HKUKR3egodflTjR7bwZ_qb7ThIrNfRe0d9WCppQFxJ2tAN1QRshJdbUR8QFK.AscqW7FWYr7V2TKHVw7tSycgfzAl1_93lFdFOw9nxMvwrt2t1CTCMjmak5WtzjFFEYSsPOs535nI4IZ3YEcl4bCOlg",mdrd: "pIejV8s8uNYOegEHaPIoaA1CJ3sMxYOSEN19xzJVCf4-1732513880-1.2.1.1-4c23osfvnNqFoa_eOuiyqvp0xkBLYEyV8TfA6gtqGUyik0zCitBz6oEt9VqdarK94Bnp4T1r5PjfJ7qgOmjIyHLGN5B91PVbfcRFp1tIcV9i6iPusqBcNsi8Bj0Fz2dCgJNhYTQwv1c_JC745QUDI2q25UjvTxZTHOxNHTYjIvEsWe_nKtt72k9h_ikOjECe0dV0Jg_NRYUHEkmGD5llZZJvs86bl4Q.IYkl2nRZzvxuJbicRpyGNbQGtDfJ_Ieklj3mKHButUqvxwqzcNVD4YeK40DKwdWyzKKImyH06vsfPkYLUJAg15UJbDWZVspgiYcLgrYBBTqfEjGAkDlOgM3F8Qr6eLV49k6zTvfHKFaZ4rAbtoPFM6y6bwuKtd8Qdgydf4FPWX_rJMSuAz_gRKMozQ9tqbz1MFxc8UEiyZKQjMRRoPzdCmcTmZPN_Kq.GbRFf1oI3xEnc0DCXCJ6tmAfYqXVqnolNjiUTGlCsvFE_vl6_nLTootQYHkJpcxDRhW3gjiM57nDZdzRZ9TGt8qLHmmhi7Bq4Qrjh7P6WAGxap0YuPe8MaN5qsA5yxVoxU_CYx9Ugj9cBBa3xtC53p82Sdlo5GchmNM8klFRksFVWPNWZTHLt_cXBh3suWrcwZSYcIkhTcijxSvmUQVGezhLSV.qsSsp8lZtSrqoW2nAef42GrPE5JbGfK0tBUB_klGehPzcwlNCHX8m7tHQssbqiBY4qI2qt0T18RNrgxo5m4EcInonop28VIX1KuKjvs_qNMH.5TeAU0Cp5yOjaHZ.m6htNUXmgYHDBQG7VxhZ_01LxkyBQVEZ2p8uirTnb2r04Ac2lBtcS0WIkCkfNlgFvHCHqVaRFy1vxxN580P4nypG1pROIsP6X_GBV4QPHxJrIStpbNpcP8H1Y3I1JXJfT827lYuCWB56x_xjBoHPNDzaO7FtXa5KCwPoX5xo69qwY6KygMqWNSXncP36e9e3fmZ.DzUq61YNy7601RLVta1XF4xsbIopnfXhKvhxwHkP9wOtZge5oijS0oFhOzeQ1anG8_scvNDL.ex8HbgKHXLRLnYQB_JVyur4t5lqIm_TUf7YrKBrDSQOQ3ovB1vA5OEmct_yn9zKyzSS7BdQoU14BuNaUguAoD02VR3rOxNtghNLmNHt6ug0_9blsk6Y5FeOKy4cxaPdXyKC.o8YMsgzpbUa_3uUtwT1XTQ3yB3f_Rroi.blqnpcDFlgoCssY185.bjewDI8meQNruPFVjWM3w_fLN5mJt73tpSnlnErxK1sgDeCmy5u1A.TRRTXVx.k3XrGK9i6ILTqm._7G_KGc_NxT.4xdsThRoTV1uYR5CHp6G8muSLN2H19gdJXNhnQQN.WKfTWPrjfkaldkj4O4oVG0.Q6tEbXlCJT0m.7sBM75YjqvozxfLbyul6MEISuSgKm410uzkRsuxXb8b9kQHlOJqr4gGnfxiTe0fG50U.6zzDNOQV864_gc60SoB.C8sEIEBFEVqdHYnApBr.ICnQEXQcUP8qSxtFnomxDI6z9FkUqjGyRh6zWYlSxjV8f.3GzXfLITsuz.1jMiwiFgdUDlXtmp4gP4Rxs5NE41D9LvRCs7J8lk0ZH6ZgQay4.w7zOmQkFb022TlBsK6x.RyEOdMVdqFs3kHov.W1oIOHRvDXpWnHF47MMpzywEYl5et5ZGrme5Z8rdD.f20Ou_0BvlBTTmVNyVLvMkTbVUu8QHF0ZmDPvt.4k8pkSpOaQDGkgayJUQ79lJ2bvpYKoj4WScX7GZA637_vIsp9Jwm.7j0_NmAXrOupaaWQnaDwe0GGWNFFpudzUU4tdURls6MTZAEznlNjs6KxLVAKVAcJX241WKFpnq3.9IYpnxNdRZ2dZhfrDJgJtJ.zf3YBX24_DVegxPZC38jFsYZJRfRFxPcbPESs_O1zIt7aRBrFs5BcxufAg731mgsU"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=8e7f5dc77ee344bb';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/ja8053805?__cf_chl_rt_tk=5P15G7ehAP7HdXu_LObopay0jJJhYEpS57h5CqAgAJ4-1732513880-1.0.1.1-0nrl_3_tp1aO4mFFVLlvFMAa007ovZdL51AqDj4qRvE" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>