CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "journals.physiology.org",cType: 'managed',cRay: '8ec08dd39f68ce13',cH: '0hBAEBns7nBJqwQb.TSD2kodo0k5ZI5NW90XHbYGwaU-1733197422-1.2.1.1-92aYw2Rf9LFggsvAgNIdKZPyICQWlSBC112AzK5GOgHhN..FPUb.FO1MGkcM9SOP',cUPMDTk: "\/doi\/10.1152\/ajplung.2000.279.6.L1066?__cf_chl_tk=6r0yDNuny9m6esiBdLyapCNRPcCdivqYw9UbIHmE.wE-1733197422-1.0.1.1-ryvlokZO5GQOp07DBc_ChWOvn6mmsbcIXfn.lFNNJug",cFPWv: 'b',cITimeS: '1733197422',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1152\/ajplung.2000.279.6.L1066?__cf_chl_f_tk=6r0yDNuny9m6esiBdLyapCNRPcCdivqYw9UbIHmE.wE-1733197422-1.0.1.1-ryvlokZO5GQOp07DBc_ChWOvn6mmsbcIXfn.lFNNJug",md: "fSHKeQqUi3MurfTc21kC48655DNdquVgI7x.zd.hano-1733197422-1.2.1.1-F4bPULfVFSHfyVytaGS4QppqFAVJmO9bbnjjfMW.6nJ1H.XkHrkOymiTTmFkf5ozHDNOR22oOVg3FhIP.ElcARNhCzQACqbhYxasAixdzPxksy_97vB1LrAcx9JN5xmwh_r0lQi0Kqhamm3umbnI1AcIsDuSiRsCQDRqu2okL2NeEKAaTb05_oN6SaDOT5RErl5bno37hRKLIrJTABvgdJvWjOA9IDXsRse36YUay5a3FtTn7vw.._om6dABttph64eEQJC4gPYTrip1yUZw2aTT.WFNWfmXjXB4GMBRgzxwPMHk56xqq0AWwIurLqNZXjUIkE21Kkq9OdYIbvXAOTYoeOrkiz5Rimn2gIYT0OGC0pk3T.KR1JDLEuPQfvHy6EuwsEkoe8w0803DpyLDn8HwtVrjw6cMutl224c.2vhIsEqnDKb8F_pltLzjjPWoR3i68ghZ90JMtxVLhwzJHcXAz2nvNYQITOz9LqMtn6vUVuIJ8rRBFdiUXzDtx2w5S3cYmUoPME_OsIdSbKq6Xc5VRRbn0mDd3PO4LXL31t55UUKhYZjDXwTCudzaUau2vdQj.Xj6d5s2dBZBRjiqciPUnN_Riq0EYBtTwcWNq3p.HfXW3qFYX5h31M3SSjAyMcXvaealbBpyNyfKEq..uBAQCNQdFdhfLZuj9PExSB71RHtxDHj192oPzlICb_oyDkkF70jnOpGITGyjOi0xCDePXqg_b1RETv.4ozFUKwEdgFQFzo9tqJRvlOuQFx8e_5X_hUg7IIM3NI1LZoItKpUGrzF2Zf2TWnMgvKnPnuzqB6YbYB20Jk1aTVDewKo9FCLYp3.UDD9HpXUZNOm5Koz6iXla2N0vrVRpSSIHtlc8GDlH6g.h3gyvWeRorECZeJcbyWor.RuR._1IY4cnoMeb5gPM56RWKHqf0xAU9G3QJrz9901nuOFjHHMO9Cw595zWWkb2ZquJRDBcngEPDOhDX4Ixhfv3TQ33Cv.54ZABvGFp1kcrb3VHDxJvneKrcbEWsPCpXs1IBtH9gYsLl.gSJxtH9ce110F8aRYevG9XGYC.FHPdJUSId51tt0MHzxPykSIzQuVAyG4KEBo92Q0LwEJ8FAzCbN0ZRw99mlB4eDTttFZxpMxhbmJOGc3dyPfkQDSatTGthFhe0NEu1rhWkC3wQbe3nJlgSSEy.Y9FqQ.uGqOIjGZs.VPGVM.9FDFPelUKuG_2F5ijz1ETFgQ6bQRZS_8pwI3QprZzKvzG3OfUZ0lG5WONtaxnGXI0wNs8op4TEvJCHa8hFuhx6cePXZ2M280o2obhiT_QbP4bJ8GRRadrYJ_0Y_V1aU3ZbOzGAlP6eMabmhXysV7YR0g7Ycfxhx51IArjPCfIiRfvoXUra4txoIyMboBVyOdRVW48x.lNgvlcNN0Hnnz5TS94WJzuq.Wegdx6YognuxXxKzUWNVSOlOO_XtFFPN_Na.NH6xmkzgCwpTz6_luT0lwxX8wxxBNeVAgMHtK4x8.oTDeckjGwDi1PdeB.y1CCuZqqR1zHY9Ta2.3i2ce1KiHixL_Tfq0BcCHBmUeT7YAPTAFNz9cVPtDWciL_GnWtHIinHGNjRxRHxHLmenlD23qdgQv_p7X623hS2ZYJmrP05w_sxCB.iVkST_HQA5MBVWYmNZZYYWYn0f_NWMmtxjt3KGegGToS.OYzr3c6GE4EoEKukIyT1yJU1pCDfAjwltWTolIFPau3A4hu0ngtMub1nXUvMOib8cE9xl9Bxrek6xfpAIcrsH0Ohnh216wGxjsVrsSqm2JSVofjqaSnGmXwgN4Z1ViJ45TchynbBizIklDAw5H66gZgkV2w6.NMHVyOV7rDsWL9gYnlrVqgCjg.A7CP.Y5NQZhvP0eqjDACvT5MYJaeKzSXpjzH42uAjGrmR0p_y6jqFZo48Dm7oGy_SUzKlHf.4rbfGpT77_s8Kudfiw7KPWYKUWa71KEx.VY83UZqU1Ar5vLcIi3zxjbheikKbGFAZGB3ItlXxIcK5zTtqKUmfpvVoHutIo4_4b4tFHF3gxNnjriEvIwuUOqO4JB4M5xmxzCWPE70Kb_hiyAkmxgfL.x3URnwiKeNdTyTdRX7XoWKa53Zaxa9btt7yQD4VLz0y2mLvDgfF.a.65uPgACsre18eQAu8RT5l8y81zJhj7EHUbf9h18icM7Myy.GDqGDFb7_KRQqeqgU1jgo9A2Ep.h_VabfhBgX6Vkp3SKCG1dplroESImxyFcZeCfpAXWjKxPRG0iS5WeR10PzRnj.8QXqhiOew.UvcoonqifglRayMAg8vXoJo0adr_gpPLlPJhHk1.XXtKz_8x_4N_Ycsdt3QnOGZaKG_au_bvchFy9OVeeY5zs7NM8I7y5HiEANQuM6ALDFDcaP2.CFYVkD2jv61rMtgOuZT9vAwRalzGuGuRGlkP.1JlpzZ.XxC1JhuMxCvBOKINhMzxCqAt3YOR8pLPVDy27W3LfCnEkknIakkwts.n7SyVwgbD5c2rGRjGo4lxcSN76GwXywqmldK1FLDLCWljU9nnYhBVXLMGkdSTOrdcKrE2R7M8VBRFy5BbyEO.D0K8gnlZ0VOGpeLG_GEH3_1j7XKaidzL78UGxHIeWsE7IPFqJpZHoC6VkzzS5MoubUzb1ohSlLiH75IUlIzRFAEDyaevFpreYzgjXDAPR3xovqkxyc2w0wUx48vF3c3cwitxve2Nv1gZqO0CB4FL4IIkRIlNsc1FUs4IA2OiXuUV.w_y94QEftWB42EdOjOApA0OQAV8jAAnFXAvfvfeTQLZz2HLFBjs.I90eHcrC0Gz2JjByrn3Z_aD1wJQSTC.RnQMvl7q93sYvWXv11BeN2kJ5TpXowAwFOqDg9LxcuOEBRXgJGN8Cx7zOZTihXhar87JinWXf2OZZ.lBne1p_wfiGcf6JDAhT1ZwdyvMxMumfN7ehVuY6Xs.hqUjTG4tzycyNqQrCp8ejxxtBbz96d9GOQtJ14EiFniXJ3Eu9fKU5iKg",mdrd: "7BbL939Rt252uOec2LeSEkwMqwOmY_JSbNFhXNWpPyo-1733197422-1.2.1.1-LxMnE5wwdR0OmHXhwvX6eOSqZR2_CAuSlqE8hobB_tkqbqqSuusvXNXoer2fFFFlTzN.APr_6i9HGglKm_PqcoUC6COJ3c1pESBmro01SyrWoL.Sy0VYGLQozWpJnoNH.5P4JzctebYlhs9HHSy8VI12Kg.LJOLiel4fledZstSdl4KgL4X45on3kzggREruaCk2GZFtfHGY1qp2tB7gW52XfmFuuWIsxNtVc2ipeo7GOG.Q5isluLax7QaKHcuWNew1VUtguSPvdznInziDKvzKB2dFgZ8OapYrsKQMJVE0rtNkSfGnsfWEiL.h88mNtKYx_WnyG5L7AQjEJNI86gb_z8lt7rIYZ6w6ra_dSLrLVhl7on.c3723_v9IOa4Y0lLyRLYZCTe4G.lz16qRapNLXM57vbSLQ2y6n4xjc03BwmMFE8QaXOCl9Z3rl0twiNcB.XdkK3gn_NIYd2iOfBm2QqDtSn9y8g3VlgMaD.57esztgQVCZCZV0LsVEal1tPPG5NlOpkHI2KSgb4V5Xi4PKiFcUFc024gNB8OOX4y6IELJB3gA5r3SU7aMSL3JQigOVNMnB8F2FO8ZM4CIrURyJHLQfaw8ZcIo.qhGdv3BY7hFSjr0KUefbXJXy7CdDki5yUAefA5gUC4.czUCvYIcDs5N_GPDKvAxgcmyah1ipkY6KANH_3F2Y4BdGOX.5_yWJp5pg5LUxLK25GZKck8ouPlr4_9cH0z4gF4r13VwGPhK30aaMRWYep6occbEKkNS3EzcSsza4799beiNdtyON6SONQxnD2tjdJ0DE4v4XC4J.TKyb8iMkVVr82Gmcb_sara3BH89ZqmiBgz2LOdJaDPjHimSjnWlHij5zY3OqbAISSHJsuxW3xXRlijzZHyRmFsVabevQSSqgKtXG0SE3U0eqjwERZDJh6UHzJKIVP2V0OdQeJyo_ui5SrPPxiPhNuSLtfCG3zhLBJ0hU8ynYCHDxbxdnB34RKucANNjFoqf51T41.3ilXC_9MZ.0.SQZ7E7OX8f4RcBv.EcymFdYTITR4qefQmaWzA3C_BNassfmNc1n6OYFJp0MYCeIIu3OldKI6RRvQIr1OAOX8OCu2zqTb5nPrOcnD4wQuR9NttKOTItSydaoUOFF_csl1X4JrZk06tu6d.VyyYHwq0gutdab3mN4WyeS4e9yY15jltyL7yjhX4FJ5tSMNLRTmsKzenH2_6NXPePO0NgbHBOp2PyPTXfAASL9pE7tKA7M.YvY1g.kWIbQUrnidFlLPoPNTltWTeBh8LVqdzJZOVY_bTiixUn5m8bRy8uElSA4pPMi.XIixNQlrCR73kpWZ4Jy1K_iWFNszV9s3bKUsYsP_OrNPOJAOz5jiOj8iMKgnpV0icq8uHj9_7SdePXJjPljsaagm0fEY72WWKrtx8v.2h4hmdMYbr7FJTwgipPgYJO9EWi.4ULg91DJtc46zLqZq82bCkasCBlqAeDqXKRMWujX0f5bDIv8O_4.J0thCN7GvIkZxrlX_q4eBetslamq.0g5hTHgpEFYs_Vkwv_Pw4ZeckM1Xe.JQSD6p0UypzEvM3pl9WW1i5gTNWWN_xVZvEtd53IWvSq2magXM94P55FGZ0kp9LNC3EO.1RHKeXPOuohlyCmhquiY9Z_6IYKhQNt1aVSogamNJtz1XJl0gGrL.ZWjkoOrHkPILZubLaSblMQZLuJUG3pz1_pBsKfcY2igc4m6k4Z328dmHqB99OdJakpVaUWgIJyFbouXa_5O7S2LTUs6VfPnqcG_lHWI0VRH72KfCWeRRDM.n_kOx_hW7x6E8LKh89kmQDbQ8UQnW91YPsBE6PNpvRoGTul6X4CPqobtBR5_4DDfJBcojm0KRd1Uawtnuvh2vnw9SQy7S9j6vxLailNlWzywBd6asRtHEA3thxCBLJ0zR7733bSqKMwVvX1FrzYxXfupiCkFT9_Iv0HIt8ya6vy"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8ec08dd39f68ce13';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1152\/ajplung.2000.279.6.L1066?__cf_chl_rt_tk=6r0yDNuny9m6esiBdLyapCNRPcCdivqYw9UbIHmE.wE-1733197422-1.0.1.1-ryvlokZO5GQOp07DBc_ChWOvn6mmsbcIXfn.lFNNJug" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>