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Research & Development World</title> <meta name="description" content="Researchers at Oak Ridge National Laboratory have developed a physics-informed, active learning (AL)-driven autonomous microscopy, which enables active autonomous discovery of physics during real-time experiments." /> <link rel="canonical" href="https://www.rdworldonline.com/physics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Physics-Informed, Active Learning–Driven Autonomous Microscopy for Science Discovery is the R&D 100 winner of the day - Research & Development World" /> <meta property="og:description" content="Researchers at Oak Ridge National Laboratory have developed a physics-informed, active learning (AL)-driven autonomous microscopy, which enables active autonomous discovery of physics during real-time experiments." /> <meta property="og:url" content="https://www.rdworldonline.com/physics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day/" /> <meta property="og:site_name" content="Research & Development World" /> <meta property="article:published_time" content="2024-06-25T21:41:29+00:00" /> <meta property="og:image" content="https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery2.jpg" /> <meta property="og:image:width" content="209" /> <meta property="og:image:height" content="200" /> <meta property="og:image:type" content="image/jpeg" /> <meta name="author" content="Heather Hall" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Written by" /> <meta name="twitter:data1" content="Heather Hall" /> <meta name="twitter:label2" content="Est. reading time" /> <meta name="twitter:data2" content="1 minute" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://www.rdworldonline.com/physics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day/","url":"https://www.rdworldonline.com/physics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day/","name":"Physics-Informed, Active Learning–Driven Autonomous Microscopy for Science Discovery is the R&D 100 winner of the day - 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class="site-inner"><div class="wrap"><div class="content-sidebar-wrap"><main class="content"><article class="type-post entry" aria-label="Physics-Informed, Active Learning–Driven Autonomous Microscopy for Science Discovery is the R&D 100 winner of the day"><header class="entry-header"><h1 class="entry-title">Physics-Informed, Active Learning–Driven Autonomous Microscopy for Science Discovery is the R&D 100 winner of the day</h1> <p class="entry-meta"><span class="entry-author">By <a href="https://www.rdworldonline.com/author/hhall/" class="entry-author-link" rel="author"><span class="entry-author-name">Heather Hall</span></a></span> | <time class="entry-time">June 25, 2024</time></p></header><div class="entry-content"><div class="addtoany_share_save_container addtoany_content addtoany_content_top"><div class="a2a_kit a2a_kit_size_16 addtoany_list" data-a2a-url="https://www.rdworldonline.com/physics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day/" data-a2a-title="Physics-Informed, Active Learning–Driven Autonomous Microscopy for Science Discovery is the R&D 100 winner of the day"><a class="a2a_button_facebook" href="https://www.addtoany.com/add_to/facebook?linkurl=https%3A%2F%2Fwww.rdworldonline.com%2Fphysics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day%2F&linkname=Physics-Informed%2C%20Active%20Learning%E2%80%93Driven%20Autonomous%20Microscopy%20for%20Science%20Discovery%20is%20the%20R%26D%20100%20winner%20of%20the%20day" title="Facebook" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_x" 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href="https://www.addtoany.com/add_to/email?linkurl=https%3A%2F%2Fwww.rdworldonline.com%2Fphysics-informed-active-learning-driven-autonomous-microscopy-for-science-discovery-is-the-rd-100-winner-of-the-day%2F&linkname=Physics-Informed%2C%20Active%20Learning%E2%80%93Driven%20Autonomous%20Microscopy%20for%20Science%20Discovery%20is%20the%20R%26D%20100%20winner%20of%20the%20day" title="Email" rel="nofollow noopener" target="_blank"></a><a class="a2a_dd addtoany_share_save addtoany_share" href="https://www.addtoany.com/share"></a></div></div><p><a href="https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery.jpg"><img fetchpriority="high" decoding="async" class="alignleft size-medium wp-image-72581" src="https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery-300x287.jpg" alt="" width="300" height="287" srcset="https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery-300x287.jpg 300w, https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery-768x735.jpg 768w, https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery-249x238.jpg 249w, https://www.rdworldonline.com/wp-content/uploads/2024/06/Product-Photo-of-Physics-Informed-Active-Learning-Driven-Autonomous-Microscopy-for-Science-Discovery.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" /></a>There are multiple challenges to developing autonomous microscopy. It requires a balance between the workflows, development of task-specific machine-learning methods, understanding of the interplay between physics discovery and machine learning and end-to-end definition of the discovery workflows. Researchers at <strong>Oak Ridge National Laboratory</strong> have developed a physics-informed, active learning (AL)-driven autonomous microscopy, which enables active autonomous discovery of physics during real-time experiments. This product is universal to any microscopic technique and can be adapted for application in other experiments, such as chemical syntheses and battery lifetime testing. The software suite comprises active learning algorithms and control software for microscopes and other experimental tools that expedite scientific discovery.</p> <p> </p> <p> </p> </div><footer class="entry-footer"></footer></article><div class="related-articles"><h4 class="block-header">Related Articles <a href="https://www.rdworldonline.com/topics/rd-100/">Read More ></a></h4><div class="article-listing"><div class="row"><article class="entry-summary"><a href="https://www.rdworldonline.com/call-for-nominations-the-2025-rd-100-awards/" class="entry-image-link"><img width="268" height="170" src="https://www.rdworldonline.com/wp-content/uploads/2024/08/RD100-268x170.jpg" class="attachment-ea_summary size-ea_summary wp-image-72884 wp-post-image" alt="R&D 100 Awards" decoding="async" /></a><h5 class="entry-title"><a href="https://www.rdworldonline.com/call-for-nominations-the-2025-rd-100-awards/">Call for Nominations: The 2025 R&D 100 Awards</a></h5></article><article class="entry-summary"><a href="https://www.rdworldonline.com/berelex-green-eco-friendly-antiviral-antifungal-and-antibacterial-paint/" class="entry-image-link"></a><h5 class="entry-title"><a href="https://www.rdworldonline.com/berelex-green-eco-friendly-antiviral-antifungal-and-antibacterial-paint/">R&D 100 winner of the day: Berelex Green eco-friendly, antiviral, antifungal, and antibacterial paint</a></h5></article><article class="entry-summary"><a href="https://www.rdworldonline.com/frontier-radio/" class="entry-image-link"></a><h5 class="entry-title"><a href="https://www.rdworldonline.com/frontier-radio/">R&D 100 winner of the day: Frontier-X</a></h5></article><article class="entry-summary"><a href="https://www.rdworldonline.com/traffic-violation-catcher/" class="entry-image-link"></a><h5 class="entry-title"><a href="https://www.rdworldonline.com/traffic-violation-catcher/">R&D 100 winner of the day: Traffic Violation Catcher</a></h5></article></div></div></div></main><aside class="sidebar sidebar-primary widget-area" role="complementary" aria-label="Primary Sidebar"><section id="custom_html-11" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><div class="textwidget custom-html-widget"><center> <div style="display: flex; flex-direction: column; justify-content: center; width: 300px;"> <div align="center"> <a href="https://www.rdworldonline.com/enews-sign-up/" target="_blank"> <img src="https://www.rdworldonline.com/wp-content/uploads/2023/12/RDWorld-300x100-1.jpg" alt="rd newsletter"> </a> </div> <div align="center" style="width: 300px; line-height: 20px; padding-top: 10px;"> <span style="font-weight: bold; color: #0c506d; text-align: center; font-size: 20px;"> EXPAND YOUR KNOWLEDGE AND STAY CONNECTED </span> </div> <div align="center" style="line-height: 16px; padding-top: 5px;"> <span style="text-align: center; font-size: 16px;"> Get the latest info on technologies, trends, and strategies in Research & Development. </span> </div> <div align="center" style="padding-top: 10px;"> <a href="https://www.rdworldonline.com/enews-sign-up/"> <button style="background-color: #18325b; color: white; font-weight: bold; border: none; padding: 10px; font-size: 16px; cursor: pointer;"> GET THE ENEWSLETTER </button> </a> </div> </div> </center> </div></div></section> <section id="custom_html-5" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><div class="textwidget custom-html-widget"><center><div id='div-gpt-rdworld_sidebar1' style="align:center"> <script> googletag.cmd.push(function() { googletag.display('div-gpt-rdworld_sidebar1'); }); </script> </div> </center></div></div></section> <section id="custom_html-10" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><div class="textwidget custom-html-widget"><center><a href="https://index.rdworldonline.com"><img src="/wp-content/uploads/2023/05/RD-House-Promo.jpg" alt="RD 25 Power Index"></a></center></div></div></section> <section id="custom_html-8" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><h4 class="widget-title widgettitle">R&D World Digital Issues</h4> <div class="textwidget custom-html-widget"><div id="digital" style="padding: 0 15px 10px 15px;"> <a href="/topics/digital-issues/"><img align="left" style="padding:0 10px; width: 100px;" src="/wp-content/uploads/2025/01/rdworld-fall24-coverifinal.jpg" alt="Fall 2024 issue" /></a> <p><a href="/topics/digital-issues/" style="text-decoration: underline;">Browse the most current issue</a> of R&D World and back issues in an easy to use high quality format. 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