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id="toc-Acute_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Fulminant_hepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Fulminant_hepatitis"> <div class="vector-toc-text"> 1.2 Fulminant hepatitis </div> </a> <ul id="toc-Fulminant_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Chronic_hepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Chronic_hepatitis"> <div class="vector-toc-text"> 1.3 Chronic hepatitis </div> </a> <ul id="toc-Chronic_hepatitis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Causes" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Causes"> <div class="vector-toc-text"> 2 Causes </div> </a> <button aria-controls="toc-Causes-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Causes subsection </button> <ul id="toc-Causes-sublist" class="vector-toc-list"> <li id="toc-Infectious" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Infectious"> <div class="vector-toc-text"> 2.1 Infectious </div> </a> <ul id="toc-Infectious-sublist" class="vector-toc-list"> <li id="toc-Viral_hepatitis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Viral_hepatitis"> <div class="vector-toc-text"> 2.1.1 Viral hepatitis </div> </a> <ul id="toc-Viral_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Parasitic_hepatitis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Parasitic_hepatitis"> <div class="vector-toc-text"> 2.1.2 Parasitic hepatitis </div> </a> <ul id="toc-Parasitic_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bacterial_hepatitis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Bacterial_hepatitis"> <div class="vector-toc-text"> 2.1.3 Bacterial hepatitis </div> </a> <ul id="toc-Bacterial_hepatitis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Metabolic" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Metabolic"> <div class="vector-toc-text"> 2.2 Metabolic </div> </a> <ul id="toc-Metabolic-sublist" class="vector-toc-list"> <li id="toc-Alcoholic_hepatitis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Alcoholic_hepatitis"> <div class="vector-toc-text"> 2.2.1 Alcoholic hepatitis </div> </a> <ul id="toc-Alcoholic_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Toxic_and_drug-induced_hepatitis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Toxic_and_drug-induced_hepatitis"> <div class="vector-toc-text"> 2.2.2 Toxic and drug-induced hepatitis </div> </a> <ul id="toc-Toxic_and_drug-induced_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Non-alcoholic_fatty_liver_disease" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Non-alcoholic_fatty_liver_disease"> <div class="vector-toc-text"> 2.2.3 Non-alcoholic fatty liver disease </div> </a> <ul id="toc-Non-alcoholic_fatty_liver_disease-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Autoimmune" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Autoimmune"> <div class="vector-toc-text"> 2.3 Autoimmune </div> </a> <ul id="toc-Autoimmune-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Genetic" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Genetic"> <div class="vector-toc-text"> 2.4 Genetic </div> </a> <ul id="toc-Genetic-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Ischemic_hepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Ischemic_hepatitis"> <div class="vector-toc-text"> 2.5 Ischemic hepatitis </div> </a> <ul id="toc-Ischemic_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Other" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Other"> <div class="vector-toc-text"> 2.6 Other </div> </a> <ul id="toc-Other-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Mechanism" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Mechanism"> <div class="vector-toc-text"> 3 Mechanism </div> </a> <button aria-controls="toc-Mechanism-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Mechanism subsection </button> <ul id="toc-Mechanism-sublist" class="vector-toc-list"> <li id="toc-Viral_hepatitis_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Viral_hepatitis_2"> <div class="vector-toc-text"> 3.1 Viral hepatitis </div> </a> <ul id="toc-Viral_hepatitis_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Steatohepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Steatohepatitis"> <div class="vector-toc-text"> 3.2 Steatohepatitis </div> </a> <ul id="toc-Steatohepatitis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Diagnosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Diagnosis"> <div class="vector-toc-text"> 4 Diagnosis </div> </a> <button aria-controls="toc-Diagnosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Diagnosis subsection </button> <ul id="toc-Diagnosis-sublist" class="vector-toc-list"> <li id="toc-Viral_hepatitis_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Viral_hepatitis_3"> <div class="vector-toc-text"> 4.1 Viral hepatitis </div> </a> <ul id="toc-Viral_hepatitis_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Alcoholic_versus_non-alcoholic" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Alcoholic_versus_non-alcoholic"> <div class="vector-toc-text"> 4.2 Alcoholic versus non-alcoholic </div> </a> <ul id="toc-Alcoholic_versus_non-alcoholic-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Virus_screening" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Virus_screening"> <div class="vector-toc-text"> 5 Virus screening </div> </a> <button aria-controls="toc-Virus_screening-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Virus screening subsection </button> <ul id="toc-Virus_screening-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_A" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_A"> <div class="vector-toc-text"> 5.1 Hepatitis A </div> </a> <ul id="toc-Hepatitis_A-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_B" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_B"> <div class="vector-toc-text"> 5.2 Hepatitis B </div> </a> <ul id="toc-Hepatitis_B-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_C" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_C"> <div class="vector-toc-text"> 5.3 Hepatitis C </div> </a> <ul id="toc-Hepatitis_C-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_D" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_D"> <div class="vector-toc-text"> 5.4 Hepatitis D </div> </a> <ul id="toc-Hepatitis_D-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Prevention" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prevention"> <div class="vector-toc-text"> 6 Prevention </div> </a> <button aria-controls="toc-Prevention-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Prevention subsection </button> <ul id="toc-Prevention-sublist" class="vector-toc-list"> <li id="toc-Vaccines" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Vaccines"> <div class="vector-toc-text"> 6.1 Vaccines </div> </a> <ul id="toc-Vaccines-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_A_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_A_2"> <div class="vector-toc-text"> 6.1.1 Hepatitis A </div> </a> <ul id="toc-Hepatitis_A_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_B_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_B_2"> <div class="vector-toc-text"> 6.1.2 Hepatitis B </div> </a> <ul id="toc-Hepatitis_B_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Other_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Other_2"> <div class="vector-toc-text"> 6.1.3 Other </div> </a> <ul id="toc-Other_2-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Behavioral_changes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Behavioral_changes"> <div class="vector-toc-text"> 6.2 Behavioral changes </div> </a> <ul id="toc-Behavioral_changes-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_A_3" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_A_3"> <div class="vector-toc-text"> 6.2.1 Hepatitis A </div> </a> <ul id="toc-Hepatitis_A_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_B_and_C" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_B_and_C"> <div class="vector-toc-text"> 6.2.2 Hepatitis B and C </div> </a> <ul id="toc-Hepatitis_B_and_C-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_D_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_D_2"> <div class="vector-toc-text"> 6.2.3 Hepatitis D </div> </a> <ul id="toc-Hepatitis_D_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_E" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_E"> <div class="vector-toc-text"> 6.2.4 Hepatitis E </div> </a> <ul id="toc-Hepatitis_E-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Alcoholic_and_metabolic_hepatitis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Alcoholic_and_metabolic_hepatitis"> <div class="vector-toc-text"> 6.2.5 Alcoholic and metabolic hepatitis </div> </a> <ul id="toc-Alcoholic_and_metabolic_hepatitis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Successes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Successes"> <div class="vector-toc-text"> 6.3 Successes </div> </a> <ul id="toc-Successes-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_A_4" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_A_4"> <div class="vector-toc-text"> 6.3.1 Hepatitis A </div> </a> <ul id="toc-Hepatitis_A_4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_B_3" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_B_3"> <div class="vector-toc-text"> 6.3.2 Hepatitis B </div> </a> <ul id="toc-Hepatitis_B_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_C_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_C_2"> <div class="vector-toc-text"> 6.3.3 Hepatitis C </div> </a> <ul id="toc-Hepatitis_C_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Alcoholic_hepatitis_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Alcoholic_hepatitis_2"> <div class="vector-toc-text"> 6.3.4 Alcoholic hepatitis </div> </a> <ul id="toc-Alcoholic_hepatitis_2-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> 7 Treatment </div> </a> <button aria-controls="toc-Treatment-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Treatment subsection </button> <ul id="toc-Treatment-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_A_5" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_A_5"> <div class="vector-toc-text"> 7.1 Hepatitis A </div> </a> <ul id="toc-Hepatitis_A_5-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_B_4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_B_4"> <div class="vector-toc-text"> 7.2 Hepatitis B </div> </a> <ul id="toc-Hepatitis_B_4-sublist" class="vector-toc-list"> <li id="toc-Acute" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Acute"> <div class="vector-toc-text"> 7.2.1 Acute </div> </a> <ul id="toc-Acute-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Chronic" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Chronic"> <div class="vector-toc-text"> 7.2.2 Chronic </div> </a> <ul id="toc-Chronic-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Hepatitis_C_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_C_3"> <div class="vector-toc-text"> 7.3 Hepatitis C </div> </a> <ul id="toc-Hepatitis_C_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_D_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_D_3"> <div class="vector-toc-text"> 7.4 Hepatitis D </div> </a> <ul id="toc-Hepatitis_D_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_E_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hepatitis_E_2"> <div class="vector-toc-text"> 7.5 Hepatitis E </div> </a> <ul id="toc-Hepatitis_E_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Alcoholic_hepatitis_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Alcoholic_hepatitis_3"> <div class="vector-toc-text"> 7.6 Alcoholic hepatitis </div> </a> <ul id="toc-Alcoholic_hepatitis_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Metabolic_hepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Metabolic_hepatitis"> <div class="vector-toc-text"> 7.7 Metabolic hepatitis </div> </a> <ul id="toc-Metabolic_hepatitis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Autoimmune_hepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Autoimmune_hepatitis"> <div class="vector-toc-text"> 7.8 Autoimmune hepatitis </div> </a> <ul id="toc-Autoimmune_hepatitis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Prognosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prognosis"> <div class="vector-toc-text"> 8 Prognosis </div> </a> <button aria-controls="toc-Prognosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Prognosis subsection </button> <ul id="toc-Prognosis-sublist" class="vector-toc-list"> <li id="toc-Acute_hepatitis_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Acute_hepatitis_2"> <div class="vector-toc-text"> 8.1 Acute hepatitis </div> </a> <ul id="toc-Acute_hepatitis_2-sublist" class="vector-toc-list"> <li id="toc-Fulminant_hepatitis_2" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Fulminant_hepatitis_2"> <div class="vector-toc-text"> 8.1.1 Fulminant hepatitis </div> </a> <ul id="toc-Fulminant_hepatitis_2-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Chronic_hepatitis_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Chronic_hepatitis_2"> <div class="vector-toc-text"> 8.2 Chronic hepatitis </div> </a> <ul id="toc-Chronic_hepatitis_2-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Epidemiology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Epidemiology"> <div class="vector-toc-text"> 9 Epidemiology </div> </a> <button aria-controls="toc-Epidemiology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Epidemiology subsection </button> <ul id="toc-Epidemiology-sublist" class="vector-toc-list"> <li id="toc-Viral_hepatitis_4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Viral_hepatitis_4"> <div class="vector-toc-text"> 9.1 Viral hepatitis </div> </a> <ul id="toc-Viral_hepatitis_4-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_A_6" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_A_6"> <div class="vector-toc-text"> 9.1.1 Hepatitis A </div> </a> <ul id="toc-Hepatitis_A_6-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_B_5" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_B_5"> <div class="vector-toc-text"> 9.1.2 Hepatitis B </div> </a> <ul id="toc-Hepatitis_B_5-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_C_4" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_C_4"> <div class="vector-toc-text"> 9.1.3 Hepatitis C </div> </a> <ul id="toc-Hepatitis_C_4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_D_4" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_D_4"> <div class="vector-toc-text"> 9.1.4 Hepatitis D </div> </a> <ul id="toc-Hepatitis_D_4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_E_3" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_E_3"> <div class="vector-toc-text"> 9.1.5 Hepatitis E </div> </a> <ul id="toc-Hepatitis_E_3-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Alcoholic_hepatitis_4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Alcoholic_hepatitis_4"> <div class="vector-toc-text"> 9.2 Alcoholic hepatitis </div> </a> <ul id="toc-Alcoholic_hepatitis_4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Non-alcoholic_steatohepatitis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Non-alcoholic_steatohepatitis"> <div class="vector-toc-text"> 9.3 Non-alcoholic steatohepatitis </div> </a> <ul id="toc-Non-alcoholic_steatohepatitis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> 10 History </div> </a> <button aria-controls="toc-History-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle History subsection </button> <ul id="toc-History-sublist" class="vector-toc-list"> <li id="toc-Early_observations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Early_observations"> <div class="vector-toc-text"> 10.1 Early observations </div> </a> <ul id="toc-Early_observations-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Willowbrook_State_School_experiments" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Willowbrook_State_School_experiments"> <div class="vector-toc-text"> 10.2 Willowbrook State School experiments </div> </a> <ul id="toc-Willowbrook_State_School_experiments-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Australia_antigen" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Australia_antigen"> <div class="vector-toc-text"> 10.3 Australia antigen </div> </a> <ul id="toc-Australia_antigen-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> 11 Society and culture </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Society and culture subsection </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Economic_burden" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Economic_burden"> <div class="vector-toc-text"> 11.1 Economic burden </div> </a> <ul id="toc-Economic_burden-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-2003_Monaca_outbreak" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#2003_Monaca_outbreak"> <div class="vector-toc-text"> 11.2 2003 Monaca outbreak </div> </a> <ul id="toc-2003_Monaca_outbreak-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Special_populations" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Special_populations"> <div class="vector-toc-text"> 12 Special populations </div> </a> <button aria-controls="toc-Special_populations-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Special populations subsection </button> <ul id="toc-Special_populations-sublist" class="vector-toc-list"> <li id="toc-HIV_co-infection" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#HIV_co-infection"> <div class="vector-toc-text"> 12.1 HIV co-infection </div> </a> <ul id="toc-HIV_co-infection-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pregnancy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pregnancy"> <div class="vector-toc-text"> 12.2 Pregnancy </div> </a> <ul id="toc-Pregnancy-sublist" class="vector-toc-list"> <li id="toc-Hepatitis_B_6" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_B_6"> <div class="vector-toc-text"> 12.2.1 Hepatitis B </div> </a> <ul id="toc-Hepatitis_B_6-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_C_5" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_C_5"> <div class="vector-toc-text"> 12.2.2 Hepatitis C </div> </a> <ul id="toc-Hepatitis_C_5-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hepatitis_E_4" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hepatitis_E_4"> <div class="vector-toc-text"> 12.2.3 Hepatitis E </div> </a> <ul id="toc-Hepatitis_E_4-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Vaccine" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Vaccine"> <div class="vector-toc-text"> 13 Vaccine </div> </a> <ul id="toc-Vaccine-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> 14 See also </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 15 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 16 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Toggle the table of contents </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading">Hepatitis</h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 86 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-86" aria-hidden="true" > 86 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A7%D9%84%D8%AA%D9%87%D8%A7%D8%A8_%D9%83%D8%A8%D8%AF%D9%8A" title="التهاب كبدي – Arabic" lang="ar" hreflang="ar" data-title="التهاب كبدي" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Asturian" lang="ast" hreflang="ast" data-title="Hepatitis" data-language-autonym="Asturianu" data-language-local-name="Asturian" class="interlanguage-link-target">Asturianu</a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Hepatit" title="Hepatit – Azerbaijani" lang="az" hreflang="az" data-title="Hepatit" data-language-autonym="Azərbaycanca" data-language-local-name="Azerbaijani" class="interlanguage-link-target">Azərbaycanca</a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%87%D9%BE%D8%A7%D8%AA%DB%8C%D8%AA" title="هپاتیت – South Azerbaijani" lang="azb" hreflang="azb" data-title="هپاتیت" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target">تۆرکجه</a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%B9%E0%A7%87%E0%A6%AA%E0%A6%BE%E0%A6%9F%E0%A6%BE%E0%A6%87%E0%A6%9F%E0%A6%BF%E0%A6%B8" title="হেপাটাইটিস – Bangla" lang="bn" hreflang="bn" data-title="হেপাটাইটিস" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target">বাংলা</a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D1%8B%D1%82" title="Гепатыт – Belarusian" lang="be" hreflang="be" data-title="Гепатыт" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target">Беларуская</a></li><li class="interlanguage-link interwiki-be-x-old mw-list-item"><a href="https://be-tarask.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D1%8B%D1%82" title="Гепатыт – Belarusian (Taraškievica orthography)" lang="be-tarask" hreflang="be-tarask" data-title="Гепатыт" data-language-autonym="Беларуская (тарашкевіца)" data-language-local-name="Belarusian (Taraškievica orthography)" class="interlanguage-link-target">Беларуская (тарашкевіца)</a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A5%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Хепатит – Bulgarian" lang="bg" hreflang="bg" data-title="Хепатит" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target">Български</a></li><li class="interlanguage-link interwiki-bo mw-list-item"><a href="https://bo.wikipedia.org/wiki/%E0%BD%98%E0%BD%86%E0%BD%B2%E0%BD%93%E0%BC%8B%E0%BD%9A%E0%BD%91%E0%BC%8D" title="མཆིན་ཚད། – Tibetan" lang="bo" hreflang="bo" data-title="མཆིན་ཚད།" data-language-autonym="བོད་ཡིག" data-language-local-name="Tibetan" class="interlanguage-link-target">བོད་ཡིག</a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Bosnian" lang="bs" hreflang="bs" data-title="Hepatitis" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target">Bosanski</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Catalan" lang="ca" hreflang="ca" data-title="Hepatitis" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Hepatitida" title="Hepatitida – Czech" lang="cs" hreflang="cs" data-title="Hepatitida" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Danish" lang="da" hreflang="da" data-title="Hepatitis" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target">Dansk</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Hepatitis" title="Hepatitis – German" lang="de" hreflang="de" data-title="Hepatitis" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-dv mw-list-item"><a href="https://dv.wikipedia.org/wiki/%DE%8A%DE%AA%DE%83%DE%A6%DE%89%DE%AD_%DE%8B%DE%AA%DE%85%DE%A6%DE%88%DE%AA%DE%82%DE%B0" title="ފުރަމޭ ދުޅަވުން – Divehi" lang="dv" hreflang="dv" data-title="ފުރަމޭ ދުޅަވުން" data-language-autonym="ދިވެހިބަސް" data-language-local-name="Divehi" class="interlanguage-link-target">ދިވެހިބަސް</a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Maksap%C3%B5letik" title="Maksapõletik – Estonian" lang="et" hreflang="et" data-title="Maksapõletik" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target">Eesti</a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%97%CF%80%CE%B1%CF%84%CE%AF%CF%84%CE%B9%CE%B4%CE%B1" title="Ηπατίτιδα – Greek" lang="el" hreflang="el" data-title="Ηπατίτιδα" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target">Ελληνικά</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Spanish" lang="es" hreflang="es" data-title="Hepatitis" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Hepatito" title="Hepatito – Esperanto" lang="eo" hreflang="eo" data-title="Hepatito" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target">Esperanto</a></li><li class="interlanguage-link interwiki-ext mw-list-item"><a href="https://ext.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Extremaduran" lang="ext" hreflang="ext" data-title="Hepatitis" data-language-autonym="Estremeñu" data-language-local-name="Extremaduran" class="interlanguage-link-target">Estremeñu</a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Basque" lang="eu" hreflang="eu" data-title="Hepatitis" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target">Euskara</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%87%D9%BE%D8%A7%D8%AA%DB%8C%D8%AA" title="هپاتیت – Persian" lang="fa" hreflang="fa" data-title="هپاتیت" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/H%C3%A9patite" title="Hépatite – French" lang="fr" hreflang="fr" data-title="Hépatite" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Heipit%C3%ADteas" title="Heipitíteas – Irish" lang="ga" hreflang="ga" data-title="Heipitíteas" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target">Gaeilge</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Hepatite" title="Hepatite – Galician" lang="gl" hreflang="gl" data-title="Hepatite" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-hak mw-list-item"><a href="https://hak.wikipedia.org/wiki/K%C3%B4n-y%C3%A0m" title="Kôn-yàm – Hakka Chinese" lang="hak" hreflang="hak" data-title="Kôn-yàm" data-language-autonym="客家語 / Hak-kâ-ngî" data-language-local-name="Hakka Chinese" class="interlanguage-link-target">客家語 / Hak-kâ-ngî</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EA%B0%84%EC%97%BC" title="간염 – Korean" lang="ko" hreflang="ko" data-title="간염" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-ha mw-list-item"><a href="https://ha.wikipedia.org/wiki/Ciwon_Hanta" title="Ciwon Hanta – Hausa" lang="ha" hreflang="ha" data-title="Ciwon Hanta" data-language-autonym="Hausa" data-language-local-name="Hausa" class="interlanguage-link-target">Hausa</a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%80%D5%A5%D5%BA%D5%A1%D5%BF%D5%AB%D5%BF" title="Հեպատիտ – Armenian" lang="hy" hreflang="hy" data-title="Հեպատիտ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target">Հայերեն</a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%AF%E0%A4%95%E0%A5%83%E0%A4%A4_%E0%A4%B6%E0%A5%8B%E0%A4%A5" title="यकृत शोथ – Hindi" lang="hi" hreflang="hi" data-title="यकृत शोथ" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target">हिन्दी</a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Croatian" lang="hr" hreflang="hr" data-title="Hepatitis" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target">Hrvatski</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Indonesian" lang="id" hreflang="id" data-title="Hepatitis" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-is mw-list-item"><a href="https://is.wikipedia.org/wiki/Lifrarb%C3%B3lga" title="Lifrarbólga – Icelandic" lang="is" hreflang="is" data-title="Lifrarbólga" data-language-autonym="Íslenska" data-language-local-name="Icelandic" class="interlanguage-link-target">Íslenska</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Epatite" title="Epatite – Italian" lang="it" hreflang="it" data-title="Epatite" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%93%D7%9C%D7%A7%D7%AA_%D7%9B%D7%91%D7%93" title="דלקת כבד – Hebrew" lang="he" hreflang="he" data-title="דלקת כבד" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-jv mw-list-item"><a href="https://jv.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Javanese" lang="jv" hreflang="jv" data-title="Hepatitis" data-language-autonym="Jawa" data-language-local-name="Javanese" class="interlanguage-link-target">Jawa</a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Гепатит – Kazakh" lang="kk" hreflang="kk" data-title="Гепатит" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target">Қазақша</a></li><li class="interlanguage-link interwiki-sw mw-list-item"><a href="https://sw.wikipedia.org/wiki/Homa_ya_ini" title="Homa ya ini – Swahili" lang="sw" hreflang="sw" data-title="Homa ya ini" data-language-autonym="Kiswahili" data-language-local-name="Swahili" class="interlanguage-link-target">Kiswahili</a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Гепатит – Kyrgyz" lang="ky" hreflang="ky" data-title="Гепатит" data-language-autonym="Кыргызча" data-language-local-name="Kyrgyz" class="interlanguage-link-target">Кыргызча</a></li><li class="interlanguage-link interwiki-lo mw-list-item"><a href="https://lo.wikipedia.org/wiki/%E0%BA%95%E0%BA%B1%E0%BA%9A%E0%BA%AD%E0%BA%B1%E0%BA%81%E0%BB%80%E0%BA%AA%E0%BA%9A" title="ຕັບອັກເສບ – Lao" lang="lo" hreflang="lo" data-title="ຕັບອັກເສບ" data-language-autonym="ລາວ" data-language-local-name="Lao" class="interlanguage-link-target">ລາວ</a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Latin" lang="la" hreflang="la" data-title="Hepatitis" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target">Latina</a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Hepat%C4%ABts" title="Hepatīts – Latvian" lang="lv" hreflang="lv" data-title="Hepatīts" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target">Latviešu</a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Hepatitas" title="Hepatitas – Lithuanian" lang="lt" hreflang="lt" data-title="Hepatitas" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target">Lietuvių</a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/M%C3%A1jgyullad%C3%A1s" title="Májgyulladás – Hungarian" lang="hu" hreflang="hu" data-title="Májgyulladás" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target">Magyar</a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A5%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Хепатит – Macedonian" lang="mk" hreflang="mk" data-title="Хепатит" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target">Македонски</a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%B9%E0%B5%86%E0%B4%AA%E0%B5%8D%E0%B4%AA%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B5%88%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B4%BF%E0%B4%B8%E0%B5%8D" title="ഹെപ്പറ്റൈറ്റിസ് – Malayalam" lang="ml" hreflang="ml" data-title="ഹെപ്പറ്റൈറ്റിസ്" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target">മലയാളം</a></li><li class="interlanguage-link interwiki-mr mw-list-item"><a href="https://mr.wikipedia.org/wiki/%E0%A4%95%E0%A4%BE%E0%A4%B5%E0%A5%80%E0%A4%B3" title="कावीळ – Marathi" lang="mr" hreflang="mr" data-title="कावीळ" data-language-autonym="मराठी" data-language-local-name="Marathi" class="interlanguage-link-target">मराठी</a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Penyakit_Hepatitis" title="Penyakit Hepatitis – Malay" lang="ms" hreflang="ms" data-title="Penyakit Hepatitis" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target">Bahasa Melayu</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Leverontsteking" title="Leverontsteking – Dutch" lang="nl" hreflang="nl" data-title="Leverontsteking" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E8%82%9D%E7%82%8E" title="肝炎 – Japanese" lang="ja" hreflang="ja" data-title="肝炎" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Hepatitt" title="Hepatitt – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Hepatitt" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target">Norsk bokmål</a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Hepatitt" title="Hepatitt – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Hepatitt" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target">Norsk nynorsk</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B9%E0%AD%87%E0%AC%AA%E0%AC%BE%E0%AC%9F%E0%AC%BE%E0%AC%87%E0%AC%9F%E0%AC%BF%E0%AC%B8" title="ହେପାଟାଇଟିସ – Odia" lang="or" hreflang="or" data-title="ହେପାଟାଇଟିସ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Gepatit" title="Gepatit – Uzbek" lang="uz" hreflang="uz" data-title="Gepatit" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target">Oʻzbekcha / ўзбекча</a></li><li class="interlanguage-link interwiki-pa mw-list-item"><a href="https://pa.wikipedia.org/wiki/%E0%A8%B9%E0%A9%88%E0%A8%AA%E0%A8%BE%E0%A8%9F%E0%A8%BE%E0%A8%88%E0%A8%9F%E0%A8%B8" title="ਹੈਪਾਟਾਈਟਸ – Punjabi" lang="pa" hreflang="pa" data-title="ਹੈਪਾਟਾਈਟਸ" data-language-autonym="ਪੰਜਾਬੀ" data-language-local-name="Punjabi" class="interlanguage-link-target">ਪੰਜਾਬੀ</a></li><li class="interlanguage-link interwiki-pnb mw-list-item"><a href="https://pnb.wikipedia.org/wiki/%DB%81%DB%8C%D9%BE%D8%A7%D9%B9%D8%A7%D8%A6%D9%B9%D8%B3" title="ہیپاٹائٹس – Western Punjabi" lang="pnb" hreflang="pnb" data-title="ہیپاٹائٹس" data-language-autonym="پنجابی" data-language-local-name="Western Punjabi" class="interlanguage-link-target">پنجابی</a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Zapalenie_w%C4%85troby" title="Zapalenie wątroby – Polish" lang="pl" hreflang="pl" data-title="Zapalenie wątroby" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target">Polski</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Hepatite" title="Hepatite – Portuguese" lang="pt" hreflang="pt" data-title="Hepatite" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Hepatit%C4%83" title="Hepatită – Romanian" lang="ro" hreflang="ro" data-title="Hepatită" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Гепатит – Russian" lang="ru" hreflang="ru" data-title="Гепатит" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-sco mw-list-item"><a href="https://sco.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Scots" lang="sco" hreflang="sco" data-title="Hepatitis" data-language-autonym="Scots" data-language-local-name="Scots" class="interlanguage-link-target">Scots</a></li><li class="interlanguage-link interwiki-sq mw-list-item"><a href="https://sq.wikipedia.org/wiki/Hepatiti" title="Hepatiti – Albanian" lang="sq" hreflang="sq" data-title="Hepatiti" data-language-autonym="Shqip" data-language-local-name="Albanian" class="interlanguage-link-target">Shqip</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Simple English" lang="en-simple" hreflang="en-simple" data-title="Hepatitis" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Hepatit%C3%ADda" title="Hepatitída – Slovak" lang="sk" hreflang="sk" data-title="Hepatitída" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target">Slovenčina</a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Slovenian" lang="sl" hreflang="sl" data-title="Hepatitis" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target">Slovenščina</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%A5%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82%D0%B8%D1%81" title="Хепатитис – Serbian" lang="sr" hreflang="sr" data-title="Хепатитис" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Hepatitis" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/H%C3%A9patitis" title="Hépatitis – Sundanese" lang="su" hreflang="su" data-title="Hépatitis" data-language-autonym="Sunda" data-language-local-name="Sundanese" class="interlanguage-link-target">Sunda</a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Hepatiitti" title="Hepatiitti – Finnish" lang="fi" hreflang="fi" data-title="Hepatiitti" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target">Suomi</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Hepatit" title="Hepatit – Swedish" lang="sv" hreflang="sv" data-title="Hepatit" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/Hepataytis" title="Hepataytis – Tagalog" lang="tl" hreflang="tl" data-title="Hepataytis" data-language-autonym="Tagalog" data-language-local-name="Tagalog" class="interlanguage-link-target">Tagalog</a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%95%E0%AE%B2%E0%AF%8D%E0%AE%B2%E0%AF%80%E0%AE%B0%E0%AE%B2%E0%AF%8D_%E0%AE%85%E0%AE%B4%E0%AE%B1%E0%AF%8D%E0%AE%9A%E0%AE%BF" title="கல்லீரல் அழற்சி – Tamil" lang="ta" hreflang="ta" data-title="கல்லீரல் அழற்சி" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target">தமிழ்</a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Гепатит – Tatar" lang="tt" hreflang="tt" data-title="Гепатит" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target">Татарча / tatarça</a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%B9%E0%B1%86%E0%B0%AA%E0%B0%9F%E0%B1%88%E0%B0%9F%E0%B0%BF%E0%B0%B8%E0%B1%8D" title="హెపటైటిస్ – Telugu" lang="te" hreflang="te" data-title="హెపటైటిస్" data-language-autonym="తెలుగు" data-language-local-name="Telugu" class="interlanguage-link-target">తెలుగు</a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%95%E0%B8%B1%E0%B8%9A%E0%B8%AD%E0%B8%B1%E0%B8%81%E0%B9%80%E0%B8%AA%E0%B8%9A" title="ตับอักเสบ – Thai" lang="th" hreflang="th" data-title="ตับอักเสบ" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target">ไทย</a></li><li class="interlanguage-link interwiki-din mw-list-item"><a href="https://din.wikipedia.org/wiki/Tuany%C3%ABcu%C3%A4ny" title="Tuanyëcuäny – Dinka" lang="din" hreflang="din" data-title="Tuanyëcuäny" data-language-autonym="Thuɔŋjäŋ" data-language-local-name="Dinka" class="interlanguage-link-target">Thuɔŋjäŋ</a></li><li class="interlanguage-link interwiki-tg mw-list-item"><a href="https://tg.wikipedia.org/wiki/%D2%B2%D0%B5%D0%BF%D0%BE%D1%82%D0%B8%D1%82" title="Ҳепотит – Tajik" lang="tg" hreflang="tg" data-title="Ҳепотит" data-language-autonym="Тоҷикӣ" data-language-local-name="Tajik" class="interlanguage-link-target">Тоҷикӣ</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Hepatit" title="Hepatit – Turkish" lang="tr" hreflang="tr" data-title="Hepatit" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82" title="Гепатит – Ukrainian" lang="uk" hreflang="uk" data-title="Гепатит" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-ur mw-list-item"><a href="https://ur.wikipedia.org/wiki/%D8%A7%D9%84%D8%AA%DB%81%D8%A7%D8%A8_%D8%AC%DA%AF%D8%B1" title="التہاب جگر – Urdu" lang="ur" hreflang="ur" data-title="التہاب جگر" data-language-autonym="اردو" data-language-local-name="Urdu" class="interlanguage-link-target">اردو</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Vi%C3%AAm_gan" title="Viêm gan – Vietnamese" lang="vi" hreflang="vi" data-title="Viêm gan" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li class="interlanguage-link interwiki-zh-classical mw-list-item"><a href="https://zh-classical.wikipedia.org/wiki/%E8%82%9D%E7%82%8E" title="肝炎 – Literary Chinese" lang="lzh" hreflang="lzh" data-title="肝炎" data-language-autonym="文言" data-language-local-name="Literary Chinese" class="interlanguage-link-target">文言</a></li><li class="interlanguage-link interwiki-war mw-list-item"><a href="https://war.wikipedia.org/wiki/Hepatitis" title="Hepatitis – Waray" lang="war" hreflang="war" data-title="Hepatitis" data-language-autonym="Winaray" data-language-local-name="Waray" class="interlanguage-link-target">Winaray</a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E8%82%9D%E7%82%8E" title="肝炎 – Wu" lang="wuu" hreflang="wuu" data-title="肝炎" data-language-autonym="吴语" data-language-local-name="Wu" class="interlanguage-link-target">吴语</a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E8%82%9D%E7%82%8E" title="肝炎 – Cantonese" lang="yue" hreflang="yue" data-title="肝炎" data-language-autonym="粵語" data-language-local-name="Cantonese" class="interlanguage-link-target">粵語</a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%82%9D%E7%82%8E" title="肝炎 – Chinese" lang="zh" hreflang="zh" data-title="肝炎" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target">中文</a></li> </ul> <div class="after-portlet after-portlet-lang"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q131742#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></div> </div> </div> </div> </header> <div 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.hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">"Hepatite" redirects here. For the mineral of that name, see <a href="/wiki/Baryte" title="Baryte">Baryte</a>.</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Hepatitis</th></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><a href="/wiki/File:Alcoholic_hepatitis.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Alcoholic_hepatitis.jpg/220px-Alcoholic_hepatitis.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Alcoholic_hepatitis.jpg/330px-Alcoholic_hepatitis.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/72/Alcoholic_hepatitis.jpg/440px-Alcoholic_hepatitis.jpg 2x" data-file-width="768" data-file-height="512" /></a></td></tr><tr><td colspan="2" class="infobox-full-data"><a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">Alcoholic hepatitis</a> as seen with a microscope, showing fatty changes (white circles), remnants of dead liver cells, and <a href="/wiki/Mallory_bodies" class="mw-redirect" title="Mallory bodies">Mallory bodies</a> (twisted-rope shaped inclusions within some liver cells). (<a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>)</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Infectious_disease_(medical_specialty)" class="mw-redirect" title="Infectious disease (medical specialty)">Infectious disease</a>, <a href="/wiki/Gastroenterology" title="Gastroenterology">gastroenterology</a>, <a href="/wiki/Hepatology" title="Hepatology">hepatology</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">Symptoms</a></th><td class="infobox-data"><a href="/wiki/Jaundice" title="Jaundice">Yellowish skin</a>, poor appetite, abdominal pain<a href="#cite_note-MedLine2016-1">[1]</a><a href="#cite_note-WHO2016QA-2">[2]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Complication_(medicine)" title="Complication (medicine)">Complications</a></th><td class="infobox-data"><a href="/wiki/Cirrhosis" title="Cirrhosis">Scarring of the liver</a>, <a href="/wiki/Liver_failure" title="Liver failure">liver failure</a>, <a href="/wiki/Liver_cancer" title="Liver cancer">liver cancer</a><a href="#cite_note-NIH2016-3">[3]</a></td></tr><tr><th scope="row" class="infobox-label">Duration</th><td class="infobox-data">Short term or long term<a href="#cite_note-MedLine2016-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label">Causes</th><td class="infobox-data"><a href="/wiki/Viruses" class="mw-redirect" title="Viruses">Viruses</a>, <a href="/wiki/Ethanol" title="Ethanol">alcohol</a>, toxins, autoimmune<a href="#cite_note-WHO2016QA-2">[2]</a><a href="#cite_note-NIH2016-3">[3]</a></td></tr><tr><th scope="row" class="infobox-label">Prevention</th><td class="infobox-data">Vaccination (for viral hepatitis),<a href="#cite_note-WHO2016QA-2">[2]</a> avoiding excessive alcohol</td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data">Medication, <a href="/wiki/Liver_transplant" class="mw-redirect" title="Liver transplant">liver transplant</a><a href="#cite_note-MedLine2016-1">[1]</a><a href="#cite_note-Trans2012-4">[4]</a></td></tr><tr><th scope="row" class="infobox-label">Frequency</th><td class="infobox-data">> 500 million cases<a href="#cite_note-NIH2016-3">[3]</a></td></tr><tr><th scope="row" class="infobox-label">Deaths</th><td class="infobox-data">> One million a year<a href="#cite_note-NIH2016-3">[3]</a></td></tr></tbody></table> Hepatitis is <a href="/wiki/Inflammation" title="Inflammation">inflammation</a> of the <a href="/wiki/Liver_parenchyma" class="mw-redirect" title="Liver parenchyma">liver tissue</a>.<a href="#cite_note-NIH2016-3">[3]</a><a href="#cite_note-MedlinePlus_2020-5">[5]</a> Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (<a href="/wiki/Jaundice" title="Jaundice">jaundice</a>), <a href="/wiki/Anorexia_(symptom)" title="Anorexia (symptom)">poor appetite</a>, <a href="/wiki/Vomiting" title="Vomiting">vomiting</a>, <a href="/wiki/Fatigue_(medicine)" class="mw-redirect" title="Fatigue (medicine)">tiredness</a>, <a href="/wiki/Abdominal_pain" title="Abdominal pain">abdominal pain</a>, and <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a>.<a href="#cite_note-MedLine2016-1">[1]</a><a href="#cite_note-WHO2016QA-2">[2]</a> Hepatitis is <a href="/wiki/Acute_(medicine)" title="Acute (medicine)">acute</a> if it resolves within six months, and <a href="/wiki/Chronic_condition" title="Chronic condition">chronic</a> if it lasts longer than six months.<a href="#cite_note-MedLine2016-1">[1]</a><a href="#cite_note-6">[6]</a> Acute hepatitis can <a href="/wiki/Self-limiting_(biology)" title="Self-limiting (biology)">resolve on its own</a>, progress to chronic hepatitis, or (rarely) result in <a href="/wiki/Acute_liver_failure" title="Acute liver failure">acute liver failure</a>.<a href="#cite_note-7">[7]</a> Chronic hepatitis may progress to scarring of the liver (<a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a>), <a href="/wiki/Liver_failure" title="Liver failure">liver failure</a>, and <a href="/wiki/Liver_cancer" title="Liver cancer">liver cancer</a>.<a href="#cite_note-NIH2016-3">[3]</a><a href="#cite_note-8">[8]</a> Hepatitis is most commonly caused by the virus <a href="/wiki/Hepatovirus_A" class="mw-redirect" title="Hepatovirus A">hepatovirus A</a>, <a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">B</a>, <a href="/wiki/Hepatitis_C_virus" title="Hepatitis C virus">C</a>, <a href="/wiki/Hepatitis_D_virus" class="mw-redirect" title="Hepatitis D virus">D</a>, and <a href="/wiki/Hepatitis_E_virus" class="mw-redirect" title="Hepatitis E virus">E</a>.<a href="#cite_note-WHO2016QA-2">[2]</a><a href="#cite_note-NIH2016-3">[3]</a> Other <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">viruses can also cause liver inflammation</a>, including <a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">cytomegalovirus</a>, <a href="/wiki/Epstein%E2%80%93Barr_virus" title="Epstein–Barr virus">Epstein–Barr virus</a>, and <a href="/wiki/Yellow_fever" title="Yellow fever">yellow fever virus</a>. Other common causes of hepatitis include <a href="/wiki/Alcoholism" title="Alcoholism">heavy alcohol use</a>, certain medications, toxins, other infections, <a href="/wiki/Autoimmune_diseases" class="mw-redirect" title="Autoimmune diseases">autoimmune diseases</a>,<a href="#cite_note-WHO2016QA-2">[2]</a><a href="#cite_note-NIH2016-3">[3]</a> and <a href="/wiki/Non-alcoholic_steatohepatitis" class="mw-redirect" title="Non-alcoholic steatohepatitis">non-alcoholic steatohepatitis</a> (NASH).<a href="#cite_note-NASH2014-9">[9]</a> Hepatitis A and E are mainly spread by contaminated food and water.<a href="#cite_note-NIH2016-3">[3]</a> Hepatitis B is mainly <a href="/wiki/Sexually_transmitted_infection" title="Sexually transmitted infection">sexually transmitted</a>, but may also be <a href="/wiki/Vertically_transmitted_infection" title="Vertically transmitted infection">passed from mother to baby</a> during <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> or <a href="/wiki/Childbirth" title="Childbirth">childbirth</a> and spread through infected <a href="/wiki/Blood" title="Blood">blood</a>.<a href="#cite_note-NIH2016-3">[3]</a> Hepatitis C is commonly spread through infected blood such as may occur during <a href="/wiki/Needle_sharing" title="Needle sharing">needle sharing</a> by <a href="/wiki/Drug_injection" title="Drug injection">intravenous drug users</a>.<a href="#cite_note-NIH2016-3">[3]</a> Hepatitis D can only infect people already infected with hepatitis B.<a href="#cite_note-NIH2016-3">[3]</a> Hepatitis A, B, and D are <a href="/wiki/Vaccine-preventable_diseases" class="mw-redirect" title="Vaccine-preventable diseases">preventable</a> with <a href="/wiki/Immunization" title="Immunization">immunization</a>.<a href="#cite_note-WHO2016QA-2">[2]</a> Medications may be used to treat chronic viral hepatitis.<a href="#cite_note-MedLine2016-1">[1]</a> Antiviral medications are recommended in all with chronic hepatitis C, except those with conditions that limit their life expectancy.<a href="#cite_note-AASLD-IDSA-10">[10]</a> There is no specific treatment for NASH; physical activity, a <a href="/wiki/Healthy_diet" title="Healthy diet">healthy diet</a>, and <a href="/wiki/Weight_loss" title="Weight loss">weight loss</a> are recommended.<a href="#cite_note-NASH2014-9">[9]</a> <a href="/wiki/Autoimmune_hepatitis" title="Autoimmune hepatitis">Autoimmune hepatitis</a> may be treated with <a href="/wiki/Immunosuppressants" class="mw-redirect" title="Immunosuppressants">medications to suppress the immune system</a>.<a href="#cite_note-11">[11]</a> A <a href="/wiki/Liver_transplant" class="mw-redirect" title="Liver transplant">liver transplant</a> may be an option in both acute and chronic liver failure.<a href="#cite_note-Trans2012-4">[4]</a> Worldwide in 2015, hepatitis A occurred in about 114 million people, chronic hepatitis B affected about 343 million people and chronic hepatitis C about 142 million people.<a href="#cite_note-12">[12]</a> In the United States, NASH affects about 11 million people and <a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">alcoholic hepatitis</a> affects about 5 million people.<a href="#cite_note-NASH2014-9">[9]</a><a href="#cite_note-13">[13]</a> Hepatitis results in more than a million deaths a year, most of which occur indirectly from liver scarring or liver cancer.<a href="#cite_note-NIH2016-3">[3]</a><a href="#cite_note-14">[14]</a> In the United States, hepatitis A is estimated to occur in about 2,500 people a year and results in about 75 deaths.<a href="#cite_note-15">[15]</a> The word is derived from the <a href="/wiki/Ancient_Greek" title="Ancient Greek">Greek</a> hêpar (<a href="https://en.wiktionary.org/wiki/%E1%BC%A7%CF%80%CE%B1%CF%81" class="extiw" title="wikt:ἧπαρ">ἧπαρ</a>), meaning "liver", and <a href="https://en.wiktionary.org/wiki/-itis" class="extiw" title="wikt:-itis">-itis</a> (-ῖτις), meaning "inflammation".<a href="#cite_note-16">[16]</a> <style data-mw-deduplicate="TemplateStyles:r886046785">.mw-parser-output .toclimit-2 .toclevel-1 ul,.mw-parser-output .toclimit-3 .toclevel-2 ul,.mw-parser-output .toclimit-4 .toclevel-3 ul,.mw-parser-output .toclimit-5 .toclevel-4 ul,.mw-parser-output .toclimit-6 .toclevel-5 ul,.mw-parser-output .toclimit-7 .toclevel-6 ul{display:none}</style><div class="toclimit-3"><meta property="mw:PageProp/toc" /></div> <div class="mw-heading mw-heading2"><h2 id="Signs_and_symptoms">Signs and symptoms</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=1" title="Edit section: Signs and symptoms">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Jaundice_eye.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/de/Jaundice_eye.jpg/290px-Jaundice_eye.jpg" decoding="async" width="290" height="208" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/de/Jaundice_eye.jpg/435px-Jaundice_eye.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/de/Jaundice_eye.jpg/580px-Jaundice_eye.jpg 2x" data-file-width="700" data-file-height="501" /></a><figcaption>Jaundiced eyes</figcaption></figure> Hepatitis has a broad spectrum of presentations that range from a complete lack of symptoms to severe <a href="/wiki/Liver_failure" title="Liver failure">liver failure</a>.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a><a href="#cite_note-Khalili_&_Burman-19">[19]</a> The acute form of hepatitis, generally caused by viral infection, is characterized by <a href="/wiki/Constitutional_symptoms" class="mw-redirect" title="Constitutional symptoms">constitutional symptoms</a> that are typically self-limiting.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a> Chronic hepatitis presents similarly, but can manifest <a href="/wiki/Medical_sign" class="mw-redirect" title="Medical sign">signs</a> and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ.<a href="#cite_note-Khalili_&_Burman-19">[19]</a><a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> <div class="mw-heading mw-heading3"><h3 id="Acute_hepatitis">Acute hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=2" title="Edit section: Acute hepatitis">edit</a>]</div> Acute viral hepatitis follows three distinct phases: <ol><li>The initial <a href="/wiki/Prodrome" title="Prodrome">prodromal phase</a> (preceding symptoms) involves <a href="/wiki/Non-specific" class="mw-redirect" title="Non-specific">non-specific</a> and <a href="/wiki/Flu-like" class="mw-redirect" title="Flu-like">flu-like</a> symptoms common to many acute viral infections. These include <a href="/wiki/Fatigue_(medical)" class="mw-redirect" title="Fatigue (medical)">fatigue</a>, <a href="/wiki/Nausea" title="Nausea">nausea</a>, <a href="/wiki/Vomiting" title="Vomiting">vomiting</a>, poor appetite, joint pain, and headaches.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a> Fever, when present, is most common in cases of hepatitis A and E.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Late in this phase, people can experience liver-specific symptoms, including <a href="/wiki/Choluria" title="Choluria">choluria</a> (dark urine) and clay-colored stools.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a></li> <li><a href="/wiki/Jaundice" title="Jaundice">Yellowing of the skin and whites of the eyes</a> follow the prodrome after about 1–2 weeks and can last for up to 4 weeks.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a> The non-specific symptoms seen in the prodromal typically resolve by this time, but people will develop an <a href="/wiki/Hepatomegaly" title="Hepatomegaly">enlarged liver</a> and right upper abdominal pain or discomfort.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> 10–20% of people will also experience an <a href="/wiki/Splenomegaly" title="Splenomegaly">enlarged spleen</a>, while some people will also experience a mild unintentional weight loss.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Khalili_&_Burman-19">[19]</a></li> <li>The recovery phase is characterized by resolution of the clinical symptoms of hepatitis with persistent elevations in <a href="/wiki/Liver_function_tests" title="Liver function tests">liver lab values</a> and potentially a persistently enlarged liver.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> All cases of hepatitis A and E are expected to fully resolve after 1–2 months.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Most hepatitis B cases are also self-limiting and will resolve in 3–4 months. Few cases of hepatitis C will resolve completely.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a></li></ol> Occasionally, however, acute hepatitis can cause <a href="/wiki/Liver_failure" title="Liver failure">liver failure</a>. Liver failure can be life threatening and may lead to a <a href="/wiki/Coma" title="Coma">coma</a> or even death.<a href="#cite_note-21">[21]</a> Both <a href="/wiki/Drug-induced_hepatitis" class="mw-redirect" title="Drug-induced hepatitis">drug-induced hepatitis</a> and <a href="/wiki/Autoimmune_hepatitis" title="Autoimmune hepatitis">autoimmune hepatitis</a> can present very similarly to acute viral hepatitis, with slight variations in symptoms depending on the cause.<a href="#cite_note-Fontana_&_Hayashi-22">[22]</a><a href="#cite_note-Manns_Lohse_Vergani-23">[23]</a> Cases of drug-induced hepatitis can manifest with systemic signs of an allergic reaction including rash, fever, <a href="/wiki/Serositis" title="Serositis">serositis</a> (inflammation of membranes lining certain organs), elevated <a href="/wiki/Eosinophil_granulocyte" class="mw-redirect" title="Eosinophil granulocyte">eosinophils</a> (a type of white blood cell), and <a href="/wiki/Bone_marrow_suppression" title="Bone marrow suppression">suppression of bone marrow activity</a>.<a href="#cite_note-Fontana_&_Hayashi-22">[22]</a> <div class="mw-heading mw-heading3"><h3 id="Fulminant_hepatitis">Fulminant hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=3" title="Edit section: Fulminant hepatitis">edit</a>]</div> Fulminant hepatitis, or massive hepatic <a href="/wiki/Necrosis" title="Necrosis">cell death</a>, is a rare and life-threatening complication of acute hepatitis that can occur in cases of hepatitis B, D, and E, in addition to drug-induced and autoimmune hepatitis.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Fontana_&_Hayashi-22">[22]</a><a href="#cite_note-Manns_Lohse_Vergani-23">[23]</a> The complication more frequently occurs in instances of hepatitis B and D co-infection at a rate of 2–20% and in pregnant women with hepatitis E at rate of 15–20% of cases.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a> In addition to the signs of acute hepatitis, people can also demonstrate signs of <a href="/wiki/Coagulopathy" title="Coagulopathy">coagulopathy</a> (abnormal coagulation studies with easy bruising and bleeding) and <a href="/wiki/Encephalopathy" title="Encephalopathy">encephalopathy</a> (confusion, disorientation, and <a href="/wiki/Somnolence" title="Somnolence">sleepiness</a>).<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-CURRENT_Diagnosis_&_Treatment-18">[18]</a> Mortality due to fulminant hepatitis is typically the result of various complications including <a href="/wiki/Cerebral_edema" title="Cerebral edema">cerebral edema</a>, <a href="/wiki/Gastrointestinal_bleeding" title="Gastrointestinal bleeding">gastrointestinal bleeding</a>, <a href="/wiki/Sepsis" title="Sepsis">sepsis</a>, <a href="/wiki/Respiratory_failure" title="Respiratory failure">respiratory failure</a>, or <a href="/wiki/Kidney_failure" title="Kidney failure">kidney failure</a>.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <div class="mw-heading mw-heading3"><h3 id="Chronic_hepatitis">Chronic hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=4" title="Edit section: Chronic hepatitis">edit</a>]</div> Acute cases of hepatitis are seen to be resolved well within a six-month period. When hepatitis is continued for more than six months it is termed chronic hepatitis.<a href="#cite_note-24">[24]</a> Chronic hepatitis is often asymptomatic early in its course and is detected only by liver laboratory studies for <a href="/wiki/Screening_(medicine)" title="Screening (medicine)">screening</a> purposes or to evaluate non-specific symptoms.<a href="#cite_note-Khalili_&_Burman-19">[19]</a><a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> As the inflammation progresses, patients can develop constitutional symptoms similar to acute hepatitis, including fatigue, nausea, vomiting, poor appetite, and joint pain.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Jaundice can occur as well, but much later in the disease process and is typically a sign of advanced disease.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Chronic hepatitis interferes with hormonal functions of the liver which can result in acne, <a href="/wiki/Hirsutism" title="Hirsutism">hirsutism</a> (abnormal hair growth), and <a href="/wiki/Amenorrhoea" class="mw-redirect" title="Amenorrhoea">amenorrhea</a> (lack of menstrual period) in women.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Extensive damage and scarring of the liver over time defines <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a>, a condition in which the liver's ability to function is permanently impeded.<a href="#cite_note-Khalili_&_Burman-19">[19]</a> This results in jaundice, weight loss, coagulopathy, <a href="/wiki/Ascites" title="Ascites">ascites</a> (abdominal fluid collection), and <a href="/wiki/Peripheral_edema" title="Peripheral edema">peripheral edema</a> (leg swelling).<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Cirrhosis can lead to other life-threatening complications such as <a href="/wiki/Hepatic_encephalopathy" title="Hepatic encephalopathy">hepatic encephalopathy</a>, <a href="/wiki/Esophageal_varices" title="Esophageal varices">esophageal varices</a>, <a href="/wiki/Hepatorenal_syndrome" title="Hepatorenal syndrome">hepatorenal syndrome</a>, and <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">liver cancer</a>.<a href="#cite_note-Khalili_&_Burman-19">[19]</a> <div class="mw-heading mw-heading2"><h2 id="Causes">Causes</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=5" title="Edit section: Causes">edit</a>]</div> Causes of hepatitis can be divided into the following major categories: infectious, metabolic, ischemic, autoimmune, genetic, and other. Infectious agents include viruses, bacteria, and parasites. Metabolic causes include prescription medications, toxins (most notably <a href="/wiki/Alcoholic_liver_disease" title="Alcoholic liver disease">alcohol</a>), and <a href="/wiki/Non-alcoholic_fatty_liver_disease" class="mw-redirect" title="Non-alcoholic fatty liver disease">non-alcoholic fatty liver disease</a>. <a href="/wiki/Autoimmune_hepatitis" title="Autoimmune hepatitis">Autoimmune</a> and genetic causes of hepatitis involve genetic predispositions and tend to affect characteristic populations.<a href="#cite_note-25">[25]</a> <div class="mw-heading mw-heading3"><h3 id="Infectious">Infectious</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=6" title="Edit section: Infectious">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Viral_hepatitis">Viral hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=7" title="Edit section: Viral hepatitis">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">Viral hepatitis</a></div> <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">Viral hepatitis</a> is the most common type of hepatitis worldwide, especially in Asia and Africa.<a href="#cite_note-26">[26]</a> Viral hepatitis is caused by five different viruses (hepatitis A, B, C, D, and E).<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <a href="/wiki/Hepatitis_A" title="Hepatitis A">Hepatitis A</a> and <a href="/wiki/Hepatitis_E" title="Hepatitis E">hepatitis E</a> behave similarly: they are both transmitted by the <a href="/wiki/Fecal%E2%80%93oral_route" title="Fecal–oral route">fecal–oral route</a>, are more common in developing countries, and are self-limiting illnesses that do not lead to chronic hepatitis.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-27">[27]</a><a href="#cite_note-28">[28]</a> <a href="/wiki/Hepatitis_B" title="Hepatitis B">Hepatitis B</a>, <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a>, and <a href="/wiki/Hepatitis_D" title="Hepatitis D">hepatitis D</a> are transmitted when blood or <a href="/wiki/Mucous_membrane" title="Mucous membrane">mucous membranes</a> are exposed to infected blood and body fluids, such as semen and vaginal secretions.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Viral particles have also been found in saliva and breastmilk. Kissing, sharing utensils, and breastfeeding do not lead to transmission unless these fluids are introduced into open sores or cuts.<a href="#cite_note-29">[29]</a> Many families who do not have safe drinking water or live in unhygienic homes have contracted hepatitis because saliva and blood droplets are often carried through the water and blood-borne illnesses spread quickly in unsanitary settings.<a href="#cite_note-30">[30]</a> Hepatitis B and C can present either acutely or chronically.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Hepatitis D is a defective virus that requires hepatitis B to replicate and is only found with hepatitis B co-infection.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> In adults, hepatitis B infection is most commonly self-limiting, with less than 5% progressing to chronic state, and 20 to 30% of those chronically infected developing cirrhosis or liver cancer.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a> Infection in infants and children frequently leads to chronic infection.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a> Unlike hepatitis B, most cases of hepatitis C lead to chronic infection.<a href="#cite_note-CDC_FAQ_on_Hepatitis_C-32">[32]</a> Hepatitis C is the second most common cause of cirrhosis in the US (second to alcoholic hepatitis).<a href="#cite_note-Friedman_55e-33">[33]</a> In the 1970s and 1980s, blood transfusions were a major factor in spreading hepatitis C virus.<a href="#cite_note-CDC_FAQ_on_Hepatitis_C-32">[32]</a> Since widespread screening of blood products for hepatitis C began in 1992, the risk of acquiring hepatitis C from a blood transfusion has decreased from approximately 10% in the 1970s to 1 in 2 million currently.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <div class="mw-heading mw-heading4"><h4 id="Parasitic_hepatitis">Parasitic hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=8" title="Edit section: Parasitic hepatitis">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Echinococcus_granulosus.JPG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d9/Echinococcus_granulosus.JPG/220px-Echinococcus_granulosus.JPG" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d9/Echinococcus_granulosus.JPG/330px-Echinococcus_granulosus.JPG 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d9/Echinococcus_granulosus.JPG/440px-Echinococcus_granulosus.JPG 2x" data-file-width="3000" data-file-height="2250" /></a><figcaption>Echinococcus granulosus</figcaption></figure> <a href="/wiki/Parasites_of_humans" class="mw-redirect" title="Parasites of humans">Parasites</a> can also infect the liver and activate the immune response, resulting in symptoms of acute hepatitis with increased serum <a href="/wiki/Immunoglobulin_E" title="Immunoglobulin E">IgE</a> (though chronic hepatitis is possible with chronic infections).<a href="#cite_note-Harder_&_Mehlhorn-34">[34]</a> Of the <a href="/wiki/Protozoa" title="Protozoa">protozoans</a>, <a href="/wiki/Trypanosoma_cruzi" title="Trypanosoma cruzi">Trypanosoma cruzi</a>, <a href="/wiki/Leishmaniasis" title="Leishmaniasis">Leishmania</a> species, and the <a href="/wiki/Malaria" title="Malaria">malaria</a>-causing <a href="/wiki/Plasmodium" title="Plasmodium">Plasmodium</a> species all can cause liver inflammation.<a href="#cite_note-Harder_&_Mehlhorn-34">[34]</a> Another protozoan, <a href="/wiki/Entamoeba_histolytica" title="Entamoeba histolytica">Entamoeba histolytica</a>, causes hepatitis with distinct liver abscesses.<a href="#cite_note-Harder_&_Mehlhorn-34">[34]</a> Of the worms, the <a href="/wiki/Cestode_infection" class="mw-redirect" title="Cestode infection">cestode</a> <a href="/wiki/Echinococcus_granulosus" title="Echinococcus granulosus">Echinococcus granulosus</a>, also known as the dog tapeworm, infects the liver and forms characteristic hepatic <a href="/wiki/Echinococcosis" title="Echinococcosis">hydatid cysts</a>.<a href="#cite_note-Harder_&_Mehlhorn-34">[34]</a> The liver <a href="/wiki/Fluke_(parasite)" class="mw-redirect" title="Fluke (parasite)">flukes</a> <a href="/wiki/Fasciola_hepatica" title="Fasciola hepatica">Fasciola hepatica</a> and <a href="/wiki/Clonorchis_sinensis" title="Clonorchis sinensis">Clonorchis sinensis</a> live in the bile ducts and cause progressive hepatitis and liver fibrosis.<a href="#cite_note-Harder_&_Mehlhorn-34">[34]</a> <div class="mw-heading mw-heading4"><h4 id="Bacterial_hepatitis">Bacterial hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=9" title="Edit section: Bacterial hepatitis">edit</a>]</div> Bacterial infection of the liver commonly results in <a href="/wiki/Pyogenic_liver_abscess" title="Pyogenic liver abscess">pyogenic liver abscesses</a>, acute hepatitis, or <a href="/wiki/Granuloma" title="Granuloma">granulomatous</a> (or chronic) liver disease.<a href="#cite_note-Wisplinghoff_&_Appleton-35">[35]</a> Pyogenic abscesses commonly involve <a href="/wiki/Enteric" class="mw-redirect" title="Enteric">enteric</a> bacteria such as <a href="/wiki/Escherichia_coli" title="Escherichia coli">Escherichia coli</a> and <a href="/wiki/Klebsiella_pneumoniae" title="Klebsiella pneumoniae">Klebsiella pneumoniae</a> and are composed of multiple bacteria up to 50% of the time.<a href="#cite_note-Wisplinghoff_&_Appleton-35">[35]</a> Acute hepatitis is caused by <a href="/wiki/Neisseria_meningitidis" title="Neisseria meningitidis">Neisseria meningitidis</a>, <a href="/wiki/Neisseria_gonorrhoeae" title="Neisseria gonorrhoeae">Neisseria gonorrhoeae</a>, <a href="/wiki/Bartonella_henselae" title="Bartonella henselae">Bartonella henselae</a>, <a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">Borrelia burgdorferi</a>, <a href="/wiki/Salmonella" title="Salmonella">salmonella</a> species, <a href="/wiki/Brucella" title="Brucella">brucella</a> species and <a href="/wiki/Campylobacter" title="Campylobacter">campylobacter</a> species.<a href="#cite_note-Wisplinghoff_&_Appleton-35">[35]</a> Chronic or granulomatous hepatitis is seen with infection from <a href="/wiki/Mycobacterium" title="Mycobacterium">mycobacteria</a> species, <a href="/wiki/Tropheryma_whipplei" class="mw-redirect" title="Tropheryma whipplei">Tropheryma whipplei</a>, <a href="/wiki/Treponema_pallidum" title="Treponema pallidum">Treponema pallidum</a>, <a href="/wiki/Coxiella_burnetii" title="Coxiella burnetii">Coxiella burnetii</a>, and <a href="/wiki/Rickettsia" title="Rickettsia">rickettsia</a> species.<a href="#cite_note-Wisplinghoff_&_Appleton-35">[35]</a> <div class="mw-heading mw-heading3"><h3 id="Metabolic">Metabolic</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=10" title="Edit section: Metabolic">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Alcoholic_hepatitis">Alcoholic hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=11" title="Edit section: Alcoholic hepatitis">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">Alcoholic hepatitis</a></div> Excessive alcohol consumption is a significant cause of hepatitis and is the most common cause of cirrhosis in the U.S.<a href="#cite_note-Friedman_55e-33">[33]</a> Alcoholic hepatitis is within the spectrum of <a href="/wiki/Alcoholic_liver_disease" title="Alcoholic liver disease">alcoholic liver disease</a>. This ranges in order of severity and reversibility from <a href="/wiki/Alcoholic_fatty_liver" class="mw-redirect" title="Alcoholic fatty liver">alcoholic steatosis</a> (least severe, most reversible), <a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">alcoholic hepatitis</a>, cirrhosis, and liver cancer (most severe, least reversible).<a href="#cite_note-Friedman_55e-33">[33]</a> Hepatitis usually develops over years-long exposure to alcohol, occurring in 10 to 20% of alcoholics.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a> The most important risk factors for the development of alcoholic hepatitis are quantity and duration of alcohol intake.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a> Long-term alcohol intake in excess of 80 grams of alcohol a day in men and 40 grams a day in women is associated with development of alcoholic hepatitis (1 beer or 4 ounces of wine is equivalent to 12g of alcohol).<a href="#cite_note-Friedman_55e-33">[33]</a> Alcoholic hepatitis can vary from asymptomatic <a href="/wiki/Hepatomegaly" title="Hepatomegaly">hepatomegaly</a> (enlarged liver) to symptoms of acute or chronic hepatitis to liver failure.<a href="#cite_note-Friedman_55e-33">[33]</a> <div class="mw-heading mw-heading4"><h4 id="Toxic_and_drug-induced_hepatitis">Toxic and drug-induced hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=12" title="Edit section: Toxic and drug-induced hepatitis">edit</a>]</div> Many chemical agents, including medications, industrial toxins, and herbal and dietary supplements, can cause hepatitis.<a href="#cite_note-Harrison's_Principles_chapter_361_(Toxic_and_Drug-Induced)-37">[37]</a><a href="#cite_note-Occupational_exposure_to_solvents-38">[38]</a> The spectrum of drug-induced liver injury varies from acute hepatitis to chronic hepatitis to acute liver failure.<a href="#cite_note-Harrison's_Principles_chapter_361_(Toxic_and_Drug-Induced)-37">[37]</a> Toxins and medications can cause liver injury through a variety of mechanisms, including direct <a href="/wiki/Cell_damage" title="Cell damage">cell damage</a>, disruption of cell metabolism, and causing structural changes.<a href="#cite_note-39">[39]</a> Some drugs such as <a href="/wiki/Paracetamol" title="Paracetamol">paracetamol</a> exhibit predictable dose-dependent liver damage while others such as <a href="/wiki/Isoniazid" title="Isoniazid">isoniazid</a> cause idiosyncratic and unpredictable reactions that vary by person.<a href="#cite_note-Harrison's_Principles_chapter_361_(Toxic_and_Drug-Induced)-37">[37]</a> There are wide variations in the mechanisms of liver injury and <a href="/wiki/Latency_period" class="mw-redirect" title="Latency period">latency period</a> from exposure to development of clinical illness.<a href="#cite_note-Friedman_55e-33">[33]</a> Many types of drugs can cause liver injury, including the <a href="/wiki/Analgesic" title="Analgesic">analgesic</a> paracetamol; <a href="/wiki/Antibiotic" title="Antibiotic">antibiotics</a> such as isoniazid, <a href="/wiki/Nitrofurantoin" title="Nitrofurantoin">nitrofurantoin</a>, <a href="/wiki/Amoxicillin/clavulanic_acid" title="Amoxicillin/clavulanic acid">amoxicillin-clavulanate</a>, <a href="/wiki/Erythromycin" title="Erythromycin">erythromycin</a>, and <a href="/wiki/Trimethoprim/sulfamethoxazole" title="Trimethoprim/sulfamethoxazole">trimethoprim-sulfamethoxazole</a>; <a href="/wiki/Anticonvulsant" title="Anticonvulsant">anticonvulsants</a> such as <a href="/wiki/Valproate" title="Valproate">valproate</a> and <a href="/wiki/Phenytoin" title="Phenytoin">phenytoin</a>; cholesterol-lowering <a href="/wiki/Statin" title="Statin">statins</a>; <a href="/wiki/Steroid" title="Steroid">steroids</a> such as <a href="/wiki/Oral_contraceptive_pill" title="Oral contraceptive pill">oral contraceptives</a> and <a href="/wiki/Anabolic_steroid" title="Anabolic steroid">anabolic steroids</a>; and <a href="/wiki/Highly_Active_Anti-Retroviral_Therapy" class="mw-redirect" title="Highly Active Anti-Retroviral Therapy">highly active anti-retroviral therapy</a> used in the treatment of <a href="/wiki/HIV/AIDS" title="HIV/AIDS">HIV/AIDS</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> Of these, amoxicillin-clavulanate is the most common cause of drug-induced liver injury, and <a href="/wiki/Paracetamol_toxicity" class="mw-redirect" title="Paracetamol toxicity">paracetamol toxicity</a> the most common cause of acute liver failure in the United States and Europe.<a href="#cite_note-Harrison's_Principles_chapter_361_(Toxic_and_Drug-Induced)-37">[37]</a> <a href="/wiki/Herb" title="Herb">Herbal remedies</a> and <a href="/wiki/Dietary_supplement" title="Dietary supplement">dietary supplements</a> are another important cause of hepatitis; these are the most common causes of drug-induced hepatitis in Korea.<a href="#cite_note-40">[40]</a> The United States–based <a rel="nofollow" class="external text" href="http://www.dilin.org/">Drug Induced Liver Injury Network</a> linked more than 16% of cases of hepatotoxicity to herbal and dietary supplements.<a href="#cite_note-NIH_-_herbal_supplements-41">[41]</a> In the United States, herbal and dietary supplements – unlike <a href="/wiki/Pharmaceutical_drug" class="mw-redirect" title="Pharmaceutical drug">pharmaceutical drugs</a> – are unregulated by the <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a>.<a href="#cite_note-NIH_-_herbal_supplements-41">[41]</a> The <a href="/wiki/National_Institutes_of_Health" title="National Institutes of Health">National Institutes of Health</a> maintains the <a rel="nofollow" class="external text" href="https://livertox.nlm.nih.gov">LiverTox</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190724165846/https://livertox.nlm.nih.gov/">Archived</a> 2019-07-24 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> database for consumers to track all known prescription and non-prescription compounds associated with liver injury.<a href="#cite_note-42">[42]</a> Exposure to other <a href="/wiki/Hepatotoxin" title="Hepatotoxin">hepatotoxins</a> can occur accidentally or intentionally through ingestion, inhalation, and skin absorption. The industrial toxin <a href="/wiki/Carbon_tetrachloride" title="Carbon tetrachloride">carbon tetrachloride</a> and the wild mushroom <a href="/wiki/Amanita_phalloides" title="Amanita phalloides">Amanita phalloides</a> are other known hepatotoxins.<a href="#cite_note-Harrison's_Principles_chapter_361_(Toxic_and_Drug-Induced)-37">[37]</a><a href="#cite_note-Occupational_exposure_to_solvents-38">[38]</a><a href="#cite_note-43">[43]</a> <div class="mw-heading mw-heading4"><h4 id="Non-alcoholic_fatty_liver_disease">Non-alcoholic fatty liver disease</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=13" title="Edit section: Non-alcoholic fatty liver disease">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Non-alcoholic_fatty_liver_disease" class="mw-redirect" title="Non-alcoholic fatty liver disease">Non-alcoholic fatty liver disease</a></div> Non-alcoholic hepatitis is within the spectrum of non-alcoholic liver disease (NALD), which ranges in severity and reversibility from <a href="/wiki/Non-alcoholic_fatty_liver_disease" class="mw-redirect" title="Non-alcoholic fatty liver disease">non-alcoholic fatty liver disease</a> (NAFLD) to non-alcoholic steatohepatitis (NASH) to cirrhosis to liver cancer, similar to the spectrum of alcoholic liver disease.<a href="#cite_note-Harrison's_Principles_chapter_364_(Nonalcoholic)-44">[44]</a> Non-alcoholic liver disease occurs in people with little or no history of alcohol use, and is instead strongly associated with <a href="/wiki/Metabolic_syndrome" title="Metabolic syndrome">metabolic syndrome</a>, obesity, <a href="/wiki/Insulin_resistance" title="Insulin resistance">insulin resistance</a> and <a href="/wiki/Diabetes_mellitus_type_2" class="mw-redirect" title="Diabetes mellitus type 2">diabetes</a>, and hypertriglyceridemia.<a href="#cite_note-Friedman_55e-33">[33]</a> Over time, non-alcoholic fatty liver disease can progress to non-alcoholic <a href="/wiki/Steatohepatitis" title="Steatohepatitis">steatohepatitis</a>, which additionally involves liver cell death, liver inflammation and possible fibrosis.<a href="#cite_note-Friedman_55e-33">[33]</a> Factors accelerating progression from NAFLD to NASH are obesity, older age, non-African American ethnicity, female gender, diabetes mellitus, hypertension, higher <a href="/wiki/Alanine_transaminase" title="Alanine transaminase">ALT</a> or <a href="/wiki/Aspartate_transaminase" title="Aspartate transaminase">AST</a> level, higher AST/ALT ratio, low platelet count, and an <a rel="nofollow" class="external text" href="http://www.nature.com/ijo/journal/v28/n10/fig_tab/0802734t1.html">ultrasound steatosis score</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> In the early stages (as with NAFLD and early NASH), most patients are asymptomatic or have mild <a href="/wiki/Quadrant_(abdomen)" class="mw-redirect" title="Quadrant (abdomen)">right upper quadrant</a> pain, and diagnosis is suspected on the basis of abnormal <a href="/wiki/Liver_function_tests" title="Liver function tests">liver function tests</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> As the disease progresses, symptoms typical of chronic hepatitis may develop.<a href="#cite_note-National_Digestive_Diseases_Information_Clearinghouse_NDDIC-45">[45]</a> While imaging can show fatty liver, only <a href="/wiki/Liver_biopsy" title="Liver biopsy">liver biopsy</a> can demonstrate inflammation and fibrosis characteristic of NASH.<a href="#cite_note-Masuoka_2013_106–122-46">[46]</a> 9 to 25% of patients with NASH develop cirrhosis.<a href="#cite_note-Friedman_55e-33">[33]</a> NASH is recognized as the third most common cause of liver disease in the United States.<a href="#cite_note-National_Digestive_Diseases_Information_Clearinghouse_NDDIC-45">[45]</a> <div class="mw-heading mw-heading3"><h3 id="Autoimmune">Autoimmune</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=14" title="Edit section: Autoimmune">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Autoimmune_hepatitis" title="Autoimmune hepatitis">Autoimmune hepatitis</a></div> Autoimmune hepatitis is a chronic disease caused by an abnormal immune response against liver cells.<a href="#cite_note-47">[47]</a> The disease is thought to have a genetic predisposition as it is associated with certain <a href="/wiki/Human_leukocyte_antigen" title="Human leukocyte antigen">human leukocyte antigens</a> involved in the immune response.<a href="#cite_note-48">[48]</a> As in other autoimmune diseases, circulating <a href="/wiki/Autoantibody" title="Autoantibody">auto-antibodies</a> may be present and are helpful in diagnosis.<a href="#cite_note-Czaja_Autoimmune-49">[49]</a> Auto-antibodies found in patients with autoimmune hepatitis include the <a href="/wiki/Sensitivity_and_specificity" title="Sensitivity and specificity">sensitive but less specific</a> <a href="/wiki/Anti-nuclear_antibody" class="mw-redirect" title="Anti-nuclear antibody">anti-nuclear antibody (ANA)</a>, smooth muscle antibody (SMA), and <a href="/wiki/Anti-neutrophil_cytoplasmic_antibody" title="Anti-neutrophil cytoplasmic antibody">atypical perinuclear antineutrophil cytoplasmic antibody (p-ANCA)</a>.<a href="#cite_note-Czaja_Autoimmune-49">[49]</a> Other autoantibodies that are less common but more specific to autoimmune hepatitis are the antibodies against liver kidney microsome 1 (LKM1) and soluble liver antigen (SLA).<a href="#cite_note-Czaja_Autoimmune-49">[49]</a> Autoimmune hepatitis can also be triggered by drugs (such as <a href="/wiki/Nitrofurantoin" title="Nitrofurantoin">nitrofurantoin</a>, <a href="/wiki/Hydralazine" title="Hydralazine">hydralazine</a>, and <a href="/wiki/Methyldopa" title="Methyldopa">methyldopa</a>), after liver transplant, or by viruses (such as hepatitis A, <a href="/wiki/Epstein%E2%80%93Barr_virus" title="Epstein–Barr virus">Epstein-Barr virus</a>, or <a href="/wiki/Measles" title="Measles">measles</a>).<a href="#cite_note-Friedman_55e-33">[33]</a> Autoimmune hepatitis can present anywhere within the spectrum from asymptomatic to acute or chronic hepatitis to fulminant liver failure.<a href="#cite_note-Friedman_55e-33">[33]</a> Patients are asymptomatic 25–34% of the time, and the diagnosis is suspected on the basis of abnormal liver function tests.<a href="#cite_note-Czaja_Autoimmune-49">[49]</a> Some studies show between 25% and 75% of cases present with signs and symptoms of acute hepatitis.<a href="#cite_note-Friedman_55e-33">[33]</a><a href="#cite_note-:0-50">[50]</a> As with other autoimmune diseases, autoimmune hepatitis usually affects young females (though it can affect patients of either sex of any age), and patients can exhibit classic signs and symptoms of autoimmunity such as fatigue, anemia, anorexia, <a href="/wiki/Amenorrhoea" class="mw-redirect" title="Amenorrhoea">amenorrhea</a>, acne, arthritis, <a href="/wiki/Pleurisy" title="Pleurisy">pleurisy</a>, <a href="/wiki/Thyroiditis" title="Thyroiditis">thyroiditis</a>, <a href="/wiki/Ulcerative_colitis" title="Ulcerative colitis">ulcerative colitis</a>, <a href="/wiki/Nephritis" title="Nephritis">nephritis</a>, and <a href="/wiki/Maculopapular_rash" title="Maculopapular rash">maculopapular rash</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> Autoimmune hepatitis increases the risk for cirrhosis, and the risk for liver cancer is increased by about 1% for each year of the disease.<a href="#cite_note-Friedman_55e-33">[33]</a> Many people with autoimmune hepatitis have other <a href="/wiki/Autoimmune_disease" title="Autoimmune disease">autoimmune diseases</a>.<a href="#cite_note-51">[51]</a> Autoimmune hepatitis is distinct from the other autoimmune diseases of the liver, <a href="/wiki/Primary_biliary_cirrhosis" class="mw-redirect" title="Primary biliary cirrhosis">primary biliary cirrhosis</a> and <a href="/wiki/Primary_sclerosing_cholangitis" title="Primary sclerosing cholangitis">primary sclerosing cholangitis</a>, both of which can also lead to scarring, fibrosis, and cirrhosis of the liver.<a href="#cite_note-Friedman_55e-33">[33]</a><a href="#cite_note-Czaja_Autoimmune-49">[49]</a> <div class="mw-heading mw-heading3"><h3 id="Genetic">Genetic</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=15" title="Edit section: Genetic">edit</a>]</div> Genetic causes of hepatitis include <a href="/wiki/Alpha_1-antitrypsin_deficiency" class="mw-redirect" title="Alpha 1-antitrypsin deficiency">alpha-1-antitrypsin deficiency</a>, <a href="/wiki/HFE_hereditary_haemochromatosis" class="mw-redirect" title="HFE hereditary haemochromatosis">hemochromatosis</a>, and <a href="/wiki/Wilson%27s_disease" title="Wilson's disease">Wilson's disease</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> In alpha-1-antitrypsin deficiency, a <a href="/wiki/Co-dominant_expression" class="mw-redirect" title="Co-dominant expression">co-dominant</a> mutation in the gene for alpha-1-antitrypsin results in the abnormal accumulation of the mutant AAT protein within liver cells, leading to liver disease.<a href="#cite_note-52">[52]</a> Hemochromatosis and Wilson's disease are both <a href="/wiki/Autosomal_recessive" class="mw-redirect" title="Autosomal recessive">autosomal recessive</a> diseases involving abnormal storage of minerals.<a href="#cite_note-Friedman_55e-33">[33]</a> In hemochromatosis, excess amounts of iron accumulate in multiple body sites, including the liver, which can lead to cirrhosis.<a href="#cite_note-Friedman_55e-33">[33]</a> In Wilson's disease, excess amounts of copper accumulate in the liver and brain, causing cirrhosis and dementia.<a href="#cite_note-Friedman_55e-33">[33]</a> When the liver is involved, alpha-1-antitrypsin deficiency and Wilson's disease tend to present as hepatitis in the neonatal period or in childhood.<a href="#cite_note-Friedman_55e-33">[33]</a> Hemochromatosis typically presents in adulthood, with the onset of clinical disease usually after age 50.<a href="#cite_note-Friedman_55e-33">[33]</a> <div class="mw-heading mw-heading3"><h3 id="Ischemic_hepatitis">Ischemic hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=16" title="Edit section: Ischemic hepatitis">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Ischemic_hepatitis" title="Ischemic hepatitis">Ischemic hepatitis</a></div> <a href="/wiki/Ischemic_hepatitis" title="Ischemic hepatitis">Ischemic hepatitis</a> (also known as shock liver) results from reduced blood flow to the liver as in shock, heart failure, or vascular insufficiency.<a href="#cite_note-Hepatic_ischemia-53">[53]</a> The condition is most often associated with <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a> but can also be caused by <a href="/wiki/Shock_(circulatory)" title="Shock (circulatory)">shock</a> or <a href="/wiki/Sepsis" title="Sepsis">sepsis</a>. <a href="/wiki/Blood_testing" class="mw-redirect" title="Blood testing">Blood testing</a> of a person with ischemic hepatitis will show very high levels of <a href="/wiki/Elevated_transaminases" title="Elevated transaminases">transaminase enzymes</a> (<a href="/wiki/Aspartate_transaminase" title="Aspartate transaminase">AST</a> and <a href="/wiki/Alanine_transaminase" title="Alanine transaminase">ALT</a>). The condition usually resolves if the underlying cause is treated successfully. Ischemic hepatitis rarely causes permanent liver damage.<a href="#cite_note-54">[54]</a> <div class="mw-heading mw-heading3"><h3 id="Other">Other</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=17" title="Edit section: Other">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Neonatal_hepatitis" title="Neonatal hepatitis">Neonatal hepatitis</a></div> Hepatitis can also occur in neonates and is attributable to a variety of causes, some of which are not typically seen in adults.<a href="#cite_note-Biliary_disease_in_infancy-55">[55]</a> Congenital or perinatal infection with the hepatitis viruses, <a href="/wiki/Toxoplasma_gondii" title="Toxoplasma gondii">toxoplasma</a>, <a href="/wiki/Rubella" title="Rubella">rubella</a>, <a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">cytomegalovirus</a>, and <a href="/wiki/Syphilis" title="Syphilis">syphilis</a> can cause neonatal hepatitis.<a href="#cite_note-Biliary_disease_in_infancy-55">[55]</a> Structural abnormalities such as <a href="/wiki/Biliary_atresia" title="Biliary atresia">biliary atresia</a> and <a href="/wiki/Choledochal_cysts" title="Choledochal cysts">choledochal cysts</a> can lead to <a href="/wiki/Cholestasis" title="Cholestasis">cholestatic liver injury</a> leading to neonatal hepatitis.<a href="#cite_note-Biliary_disease_in_infancy-55">[55]</a> <a href="/wiki/Inborn_error_of_metabolism" class="mw-redirect" title="Inborn error of metabolism">Metabolic diseases</a> such as <a href="/wiki/Glycogen_storage_disease" title="Glycogen storage disease">glycogen storage disorders</a> and <a href="/wiki/Lysosomal_storage_disease" title="Lysosomal storage disease">lysosomal storage disorders</a> are also implicated.<a href="#cite_note-Biliary_disease_in_infancy-55">[55]</a> Neonatal hepatitis can be <a href="/wiki/Idiopathy" class="mw-redirect" title="Idiopathy">idiopathic</a>, and in such cases, biopsy often shows large multinucleated cells in the liver tissue.<a href="#cite_note-56">[56]</a> This disease is termed giant cell hepatitis and may be associated with viral infection, autoimmune disorders, and drug toxicity.<a href="#cite_note-57">[57]</a><a href="#cite_note-58">[58]</a> <div class="mw-heading mw-heading2"><h2 id="Mechanism">Mechanism</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=18" title="Edit section: Mechanism">edit</a>]</div> The specific mechanism varies and depends on the underlying cause of the hepatitis. Generally, there is an initial insult that causes liver injury and activation of an inflammatory response, which can become chronic, leading to progressive <a href="/wiki/Fibrosis" title="Fibrosis">fibrosis</a> and <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a>.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <div class="mw-heading mw-heading3"><h3 id="Viral_hepatitis_2">Viral hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=19" title="Edit section: Viral hepatitis">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Stages_of_Liver_disease_NIDDK_NIH.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/Stages_of_Liver_disease_NIDDK_NIH.gif/290px-Stages_of_Liver_disease_NIDDK_NIH.gif" decoding="async" width="290" height="162" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/Stages_of_Liver_disease_NIDDK_NIH.gif/435px-Stages_of_Liver_disease_NIDDK_NIH.gif 1.5x, //upload.wikimedia.org/wikipedia/commons/1/16/Stages_of_Liver_disease_NIDDK_NIH.gif 2x" data-file-width="446" data-file-height="249" /></a><figcaption>Stages of liver disease</figcaption></figure> The pathway by which hepatic viruses cause <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">viral hepatitis</a> is best understood in the case of hepatitis B and C.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> The viruses do not directly activate <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a> (cell death).<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Nakamoto_&_Kaneko-59">[59]</a> Rather, infection of liver cells activates the <a href="/wiki/Innate_immune_system" title="Innate immune system">innate</a> and <a href="/wiki/Adaptive_immune_system" title="Adaptive immune system">adaptive</a> arms of the <a href="/wiki/Immune_system" title="Immune system">immune system</a> leading to an inflammatory response which causes cellular damage and death, including viral-induced apoptosis via the induction of the death receptor-mediated signaling pathway.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Nakamoto_&_Kaneko-59">[59]</a><a href="#cite_note-60">[60]</a><a href="#cite_note-61">[61]</a> Depending on the strength of the immune response, the types of immune cells involved and the ability of the virus to evade the body's defense, infection can either lead to clearance (acute disease) or persistence (chronic disease) of the virus.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> The chronic presence of the virus within liver cells results in multiple waves of <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>, injury and <a href="/wiki/Wound_healing" title="Wound healing">wound healing</a> that over time lead to scarring or <a href="/wiki/Fibrosis" title="Fibrosis">fibrosis</a> and culminate in <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>.<a href="#cite_note-Nakamoto_&_Kaneko-59">[59]</a><a href="#cite_note-62">[62]</a> People with impaired immune response are at greater risk of developing chronic infection.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <a href="/wiki/Natural_killer_cell" title="Natural killer cell">Natural killer cells</a> are the primary drivers of the initial innate response and create a <a href="/wiki/Cytokine" title="Cytokine">cytokine</a> environment that results in the recruitment of <a href="/wiki/T_helper_cell" title="T helper cell">CD4 T-helper</a> and <a href="/wiki/Cytotoxic_T_cell" title="Cytotoxic T cell">CD8 cytotoxic T-cells</a>.<a href="#cite_note-Rehermann_Killer_Cells-63">[63]</a><a href="#cite_note-Heim_&_Thimme-64">[64]</a> <a href="/wiki/Interferon_type_I" title="Interferon type I">Type I interferons</a> are the cytokines that drive the antiviral response.<a href="#cite_note-Heim_&_Thimme-64">[64]</a> In chronic Hepatitis B and C, natural killer cell function is impaired.<a href="#cite_note-Rehermann_Killer_Cells-63">[63]</a> <div class="mw-heading mw-heading3"><h3 id="Steatohepatitis">Steatohepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=20" title="Edit section: Steatohepatitis">edit</a>]</div> <a href="/wiki/Steatohepatitis" title="Steatohepatitis">Steatohepatitis</a> is seen in both alcoholic and non-alcoholic liver disease and is the culmination of a cascade of events that began with injury. In the case of <a href="/wiki/Non-alcoholic_fatty_liver_disease" class="mw-redirect" title="Non-alcoholic fatty liver disease">non-alcoholic steatohepatitis</a>, this cascade is initiated by changes in metabolism associated with obesity, insulin resistance, and lipid dysregulation.<a href="#cite_note-Hardy_Oakley_Anstee_Day-65">[65]</a><a href="#cite_note-Yoon_&_Cha_Pathogenesis-66">[66]</a> In <a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">alcoholic hepatitis</a>, chronic excess alcohol use is the culprit.<a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> Though the inciting event may differ, the progression of events is similar and begins with accumulation of free <a href="/wiki/Fatty_acid" title="Fatty acid">fatty acids</a> (FFA) and their breakdown products in the liver cells in a process called <a href="/wiki/Steatosis" title="Steatosis">steatosis</a>.<a href="#cite_note-Hardy_Oakley_Anstee_Day-65">[65]</a><a href="#cite_note-Yoon_&_Cha_Pathogenesis-66">[66]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> This initially reversible process overwhelms the <a href="/wiki/Hepatocyte" title="Hepatocyte">hepatocyte</a>'s ability to maintain lipid homeostasis leading to a toxic effect as fat molecules accumulate and are broken down in the setting of an <a href="/wiki/Cellular_stress_response" title="Cellular stress response">oxidative stress response</a>.<a href="#cite_note-Hardy_Oakley_Anstee_Day-65">[65]</a><a href="#cite_note-Yoon_&_Cha_Pathogenesis-66">[66]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> Over time, this abnormal lipid deposition triggers the <a href="/wiki/Immune_system" title="Immune system">immune system</a> via <a href="/wiki/Toll-like_receptor" title="Toll-like receptor">toll-like receptor 4</a> (TLR4) resulting in the production of inflammatory <a href="/wiki/Cytokine" title="Cytokine">cytokines</a> such as TNF that cause liver cell injury and death.<a href="#cite_note-Hardy_Oakley_Anstee_Day-65">[65]</a><a href="#cite_note-Yoon_&_Cha_Pathogenesis-66">[66]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> These events mark the transition to <a href="/wiki/Steatohepatitis" title="Steatohepatitis">steatohepatitis</a> and in the setting of chronic injury, <a href="/wiki/Fibrosis" title="Fibrosis">fibrosis</a> eventually develops setting up events that lead to cirrhosis and hepatocellular carcinoma.<a href="#cite_note-Hardy_Oakley_Anstee_Day-65">[65]</a> Microscopically, changes that can be seen include steatosis with large and swollen hepatocytes (<a href="/wiki/Ballooning_degeneration" title="Ballooning degeneration">ballooning</a>), evidence of cellular injury and cell death (apoptosis, necrosis), evidence of inflammation in particular in <a href="/wiki/Liver" title="Liver">zone 3 of the liver</a>, variable degrees of fibrosis and <a href="/wiki/Mallory_body" title="Mallory body">Mallory bodies</a>.<a href="#cite_note-Hardy_Oakley_Anstee_Day-65">[65]</a><a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a><a href="#cite_note-69">[69]</a> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=21" title="Edit section: Diagnosis">edit</a>]</div> <table class="wikitable" style="float: right; margin-left:15px; text-align:center"> <tbody><tr> <th scope="col">Most elevated aminotransferase </th> <th scope="col">Cause </th></tr> <tr> <td rowspan="9">ALT </td> <td>Chronic hepatitis B, C, and D </td></tr> <tr> <td>Nonalcoholic liver disease </td></tr> <tr> <td>Acute viral hepatitis </td></tr> <tr> <td>Medications/toxins </td></tr> <tr> <td>Autoimmune hepatitis </td></tr> <tr> <td>Wilson's disease </td></tr> <tr> <td>Alpha-1-antitrypsin deficiency </td></tr> <tr> <td>Hemochromatosis </td></tr> <tr> <td>Ischemic hepatitis (severe elevation up to thousands) </td></tr> <tr> <td rowspan="2">AST </td> <td>Alcoholic liver disease </td></tr> <tr> <td>Cirrhosis </td></tr></tbody></table> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Histopathology_of_acute_hepatitis.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Histopathology_of_acute_hepatitis.jpg/220px-Histopathology_of_acute_hepatitis.jpg" decoding="async" width="220" height="164" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Histopathology_of_acute_hepatitis.jpg/330px-Histopathology_of_acute_hepatitis.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Histopathology_of_acute_hepatitis.jpg/440px-Histopathology_of_acute_hepatitis.jpg 2x" data-file-width="635" data-file-height="474" /></a><figcaption>Histopathology of acute hepatitis with lobular disarray and associated lymphocytic inflammation, acidophil body formation (arrow) and bilirubinostasis.</figcaption></figure> Diagnosis of hepatitis is made on the basis of some or all of the following: a person's signs and symptoms, medical history including sexual and substance use history, blood tests, <a href="/wiki/Medical_imaging" title="Medical imaging">imaging</a>, and <a href="/wiki/Liver_biopsy" title="Liver biopsy">liver biopsy</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> In general, for viral hepatitis and other acute causes of hepatitis, the person's blood tests and clinical picture are sufficient for diagnosis.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Friedman_55e-33">[33]</a> For other causes of hepatitis, especially chronic causes, blood tests may not be useful.<a href="#cite_note-Friedman_55e-33">[33]</a> In this case, liver biopsy is the <a href="/wiki/Gold_standard_(test)" title="Gold standard (test)">gold standard</a> for establishing the diagnosis: <a href="/wiki/Histopathology" title="Histopathology">histopathologic</a> analysis is able to reveal the precise extent and pattern of inflammation and <a href="/wiki/Fibrosis" title="Fibrosis">fibrosis</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> Biopsy is typically not the initial diagnostic test because it is invasive and is associated with a small but significant risk of bleeding that is increased in people with liver injury and cirrhosis.<a href="#cite_note-70">[70]</a> Blood testing includes <a href="/wiki/Liver_function_tests" title="Liver function tests">liver enzymes</a>, <a href="/wiki/Serology" title="Serology">serology</a> (i.e. for autoantibodies), <a href="/wiki/Nucleic_acid_test" title="Nucleic acid test">nucleic acid testing</a> (i.e. for hepatitis virus DNA/RNA), <a href="/wiki/Blood_chemistry_study" class="mw-redirect" title="Blood chemistry study">blood chemistry</a>, and <a href="/wiki/Complete_blood_count" title="Complete blood count">complete blood count</a>.<a href="#cite_note-Friedman_55e-33">[33]</a> Characteristic patterns of liver enzyme abnormalities can point to certain causes or stages of hepatitis.<a href="#cite_note-71">[71]</a><a href="#cite_note-72">[72]</a> Generally, <a href="/wiki/Aspartate_transaminase" title="Aspartate transaminase">AST</a> and <a href="/wiki/Alanine_transaminase" title="Alanine transaminase">ALT</a> are elevated in most cases of hepatitis regardless of whether the person shows any symptoms.<a href="#cite_note-Friedman_55e-33">[33]</a> The degree of elevation (i.e. levels in the hundreds vs. in the thousands), the predominance for AST vs. ALT elevation, and the ratio between AST and ALT are informative of the diagnosis.<a href="#cite_note-Friedman_55e-33">[33]</a> <a href="/wiki/Medical_ultrasound" title="Medical ultrasound">Ultrasound</a>, <a href="/wiki/CT_scan" title="CT scan">CT</a>, and <a href="/wiki/Magnetic_resonance_imaging" title="Magnetic resonance imaging">MRI</a> can all identify steatosis (fatty changes) of the liver tissue and nodularity of the liver surface suggestive of cirrhosis.<a href="#cite_note-73">[73]</a><a href="#cite_note-74">[74]</a> CT and especially MRI are able to provide a higher level of detail, allowing visualization and characterize such structures as vessels and tumors within the liver.<a href="#cite_note-75">[75]</a> Unlike steatosis and cirrhosis, no imaging test is able to detect liver inflammation (i.e. hepatitis) or fibrosis.<a href="#cite_note-Friedman_55e-33">[33]</a> Liver biopsy is the only definitive diagnostic test that is able to assess inflammation and fibrosis of the liver.<a href="#cite_note-Friedman_55e-33">[33]</a> <div class="mw-heading mw-heading3"><h3 id="Viral_hepatitis_3">Viral hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=22" title="Edit section: Viral hepatitis">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">Viral hepatitis</a></div> Viral hepatitis is primarily diagnosed through blood tests for levels of viral <a href="/wiki/Antigen" title="Antigen">antigens</a> (such as the <a href="/wiki/HBsAg" title="HBsAg">hepatitis B surface</a> or <a href="/wiki/HBcAg" title="HBcAg">core</a> antigen), anti-viral antibodies (such as the anti-hepatitis B surface antibody or anti-hepatitis A antibody), or viral DNA/RNA.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Friedman_55e-33">[33]</a> In early infection (i.e. within 1 week), <a href="/wiki/Immunoglobulin_M" title="Immunoglobulin M">IgM</a> antibodies are found in the blood.<a href="#cite_note-Friedman_55e-33">[33]</a> In late infection and after recovery, <a href="/wiki/Immunoglobulin_G" title="Immunoglobulin G">IgG</a> antibodies are present and remain in the body for up to years.<a href="#cite_note-Friedman_55e-33">[33]</a> Therefore, when a patient is positive for IgG antibody but negative for IgM antibody, he is considered <a href="/wiki/Immunity_(medical)" class="mw-redirect" title="Immunity (medical)">immune</a> from the virus via either prior infection and recovery or prior vaccination.<a href="#cite_note-Friedman_55e-33">[33]</a> In the case of hepatitis B, blood tests exist for multiple virus antigens (which are different components of the <a href="/wiki/File:HBV.png" title="File:HBV.png">virion particle</a>) and antibodies.<a href="#cite_note-pmid26568915-76">[76]</a> The combination of antigen and antibody positivity can provide information about the stage of infection (acute or chronic), the degree of viral replication, and the infectivity of the virus.<a href="#cite_note-pmid26568915-76">[76]</a> <div class="mw-heading mw-heading3"><h3 id="Alcoholic_versus_non-alcoholic">Alcoholic versus non-alcoholic</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=23" title="Edit section: Alcoholic versus non-alcoholic">edit</a>]</div> The most apparent distinguishing factor between <a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">alcoholic steatohepatitis</a> (ASH) and <a href="/wiki/Nonalcoholic_Steatohepatitis" class="mw-redirect" title="Nonalcoholic Steatohepatitis">nonalcoholic steatohepatitis</a> (NASH) is a history of excessive alcohol use.<a href="#cite_note-Neuman,_French,_et_al-77">[77]</a> Thus, in patients who have no or negligible alcohol use, the diagnosis is unlikely to be alcoholic hepatitis. In those who drink alcohol, the diagnosis may just as likely be alcoholic or nonalcoholic hepatitis especially if there is concurrent obesity, diabetes, and metabolic syndrome. In this case, alcoholic and nonalcoholic hepatitis can be distinguished by the pattern of liver enzyme abnormalities; specifically, in alcoholic steatohepatitis AST>ALT with ratio of AST:ALT>2:1 while in nonalcoholic steatohepatitis ALT>AST with ratio of ALT:AST>1.5:1.<a href="#cite_note-Neuman,_French,_et_al-77">[77]</a> Liver biopsies show identical findings in patients with ASH and NASH, specifically, the presence of <a href="/wiki/Granulocyte" title="Granulocyte">polymorphonuclear</a> infiltration, hepatocyte <a href="/wiki/Necrosis" title="Necrosis">necrosis</a> and <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a> in the form of <a href="/wiki/Ballooning_degeneration" title="Ballooning degeneration">ballooning degeneration</a>, <a href="/wiki/Mallory_body" title="Mallory body">Mallory bodies</a>, and fibrosis around veins and sinuses.<a href="#cite_note-Friedman_55e-33">[33]</a> <div class="mw-heading mw-heading2"><h2 id="Virus_screening">Virus screening</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=24" title="Edit section: Virus screening">edit</a>]</div> The purpose of screening for viral hepatitis is to identify people infected with the disease as early as possible, even before symptoms and transaminase elevations may be present. This allows for early treatment, which can both prevent disease progression and decrease the likelihood of transmission to others.<a href="#cite_note-78">[78]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_A">Hepatitis A</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=25" title="Edit section: Hepatitis A">edit</a>]</div> Hepatitis A causes an acute illness that does not progress to chronic liver disease. Therefore, the role of screening is to assess immune status in people who are at high risk of contracting the virus, as well as in people with known liver disease for whom hepatitis A infection could lead to liver failure.<a href="#cite_note-79">[79]</a><a href="#cite_note-80">[80]</a> People in these groups who are not already immune can receive the <a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">hepatitis A vaccine</a>.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] Those at high risk and in need of screening include:<a href="#cite_note-WHO_Hep_A_Fact_Sheet_July_2015-81">[81]</a><a href="#cite_note-Voise_2011-82">[82]</a><a href="#cite_note-CDC_Adult_Vaccine-83">[83]</a> <ul><li>People in close contact (either living with or having sexual contact) with someone who has hepatitis A</li> <li>People traveling to an area with endemic hepatitis A</li> <li>People who do not have access to clean water</li> <li>People who use illicit drugs</li> <li>People with liver disease</li> <li>People with poor sanitary habits such as not washing hands after using the restroom or changing diapers</li></ul> The presence of anti-hepatitis A <a href="/wiki/Immunoglobulin_G" title="Immunoglobulin G">IgG</a> in the blood indicates past infection with the virus or prior vaccination.<a href="#cite_note-84">[84]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_B">Hepatitis B</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=26" title="Edit section: Hepatitis B">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Hepatitis_B_virus_v2.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Hepatitis_B_virus_v2.png/220px-Hepatitis_B_virus_v2.png" decoding="async" width="220" height="151" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Hepatitis_B_virus_v2.png/330px-Hepatitis_B_virus_v2.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Hepatitis_B_virus_v2.png/440px-Hepatitis_B_virus_v2.png 2x" data-file-width="843" data-file-height="577" /></a><figcaption>Hepatitis B virus v2</figcaption></figure> The <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a>, <a href="/wiki/World_Health_Organization" title="World Health Organization">WHO</a>, <a href="/wiki/United_States_Preventive_Services_Task_Force" title="United States Preventive Services Task Force">USPSTF</a>, and <a href="/wiki/American_Congress_of_Obstetricians_and_Gynecologists" class="mw-redirect" title="American Congress of Obstetricians and Gynecologists">ACOG</a> recommend routine hepatitis B screening for certain high-risk populations.<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a><a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a> Specifically, these populations include people who are: <ul><li>Beginning <a href="/wiki/Immunosuppressive_drug" title="Immunosuppressive drug">immunosuppressive</a> or <a href="/wiki/Chemotherapy" title="Chemotherapy">cytotoxic therapy</a><a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a></li> <li>Blood, organ, or tissue donors<a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a></li> <li>Born in countries where the prevalence of hepatitis B is high (defined as ≥2% of the population), whether or not they have been vaccinated<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a></li> <li>Born in the United States whose parents are from countries where the prevalence of hepatitis B is very high (defined as ≥8% of the population), and who were not vaccinated<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a></li> <li>Found to have elevated <a href="/wiki/Liver_function_tests" title="Liver function tests">liver enzymes</a> without a known cause<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a></li> <li><a href="/wiki/HIV/AIDS" title="HIV/AIDS">HIV</a> positive<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a></li> <li>In close contact with (i.e. live or have sex with) people known to have hepatitis B<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a></li> <li>Incarcerated<a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a></li> <li><a href="/wiki/Intravenous_drug_users" class="mw-redirect" title="Intravenous drug users">Intravenous drug users</a><a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a></li> <li><a href="/wiki/Men_who_have_sex_with_men" title="Men who have sex with men">Men who have sex with men</a><a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a></li> <li>On <a href="/wiki/Hemodialysis" title="Hemodialysis">hemodialysis</a><a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a></li> <li>Pregnant<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a></li></ul> Screening consists of a blood test that detects hepatitis B surface antigen (<a href="/wiki/HBsAg" title="HBsAg">HBsAg</a>). If HBsAg is present, a second test – usually done on the same blood sample – that detects the antibody for the hepatitis B core antigen (anti-<a href="/wiki/HBcAg" title="HBcAg">HBcAg</a>) can differentiate between acute and chronic infection.<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-89">[89]</a> People who are high-risk whose blood tests negative for HBsAg can receive the <a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">hepatitis B vaccine</a> to prevent future infection.<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a><a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_C">Hepatitis C</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=27" title="Edit section: Hepatitis C">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HCV_structure.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/HCV_structure.png/220px-HCV_structure.png" decoding="async" width="220" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/HCV_structure.png/330px-HCV_structure.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/96/HCV_structure.png/440px-HCV_structure.png 2x" data-file-width="638" data-file-height="524" /></a><figcaption>HCV structure</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><video id="mwe_player_0" poster="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv/220px--ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv.jpg" controls="" preload="none" data-mw-tmh="" class="mw-file-element" width="220" height="59" data-durationhint="39" data-mwtitle="ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv" data-mwprovider="wikimediacommons" resource="/wiki/File:ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv"><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv.480p.vp9.webm" type="video/webm; codecs="vp9, opus"" data-transcodekey="480p.vp9.webm" data-width="854" data-height="228" /><source src="//upload.wikimedia.org/wikipedia/commons/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv" type="video/ogg; codecs="theora"" data-width="960" data-height="256" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv.144p.mjpeg.mov" type="video/quicktime" data-transcodekey="144p.mjpeg.mov" data-width="256" data-height="68" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv.240p.vp9.webm" type="video/webm; codecs="vp9, opus"" data-transcodekey="240p.vp9.webm" data-width="426" data-height="114" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv.360p.vp9.webm" type="video/webm; codecs="vp9, opus"" data-transcodekey="360p.vp9.webm" data-width="640" data-height="170" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a4/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv/ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014.ogv.360p.webm" type="video/webm; codecs="vp8, vorbis"" data-transcodekey="360p.webm" data-width="640" data-height="170" /></video><figcaption>ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-Protein-Mobilises-Lipid-Stores-for-Hepatitis-C-Virus-ppat.1005568.s014</figcaption></figure> The <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a>, <a href="/wiki/World_Health_Organization" title="World Health Organization">WHO</a>, <a href="/wiki/United_States_Preventive_Services_Task_Force" title="United States Preventive Services Task Force">USPSTF</a>, <a href="/wiki/AASLD" class="mw-redirect" title="AASLD">AASLD</a>, and <a href="/wiki/American_Congress_of_Obstetricians_and_Gynecologists" class="mw-redirect" title="American Congress of Obstetricians and Gynecologists">ACOG</a> recommend screening people at high risk for hepatitis C infection.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a> These populations include people who are: <ul><li>Adults in the United States born between 1945 and 1965<a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Blood or organ donors.<a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Born to HCV-positive mothers<a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>HIV-positive<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Incarcerated, or who have been in the past<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Intranasal illicit drug users<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Intravenous drug users (past or current)<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Men who have sex with men<a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>On long-term hemodialysis, or who have been in the past<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Pregnant, and engaging in high-risk behaviors<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a></li> <li>Recipients of blood products or organs prior to 1992 in the United States<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Recipients of tattoos in an "unregulated setting"<a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Sex workers<a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a></li> <li>Workers in a healthcare setting who have had a needlestick injury<a href="#cite_note-AASLD-IDSA-10">[10]</a></li></ul> For people in the groups above whose exposure is ongoing, screening should be periodic, though there is no set optimal screening interval.<a href="#cite_note-Task_Force-92">[92]</a> The AASLD recommends screening men who have sex with men who are HIV-positive annually.<a href="#cite_note-AASLD-IDSA-10">[10]</a> People born in the US between 1945 and 1965 should be screened once (unless they have other exposure risks).<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a> Screening consists of a blood test that detects anti-hepatitis C virus antibody. If anti-hepatitis C virus antibody is present, a confirmatory test to detect HCV RNA indicates chronic disease.<a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_D">Hepatitis D</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=28" title="Edit section: Hepatitis D">edit</a>]</div> The <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a>, <a href="/wiki/World_Health_Organization" title="World Health Organization">WHO</a>, <a href="/wiki/United_States_Preventive_Services_Task_Force" title="United States Preventive Services Task Force">USPSTF</a>, <a href="/wiki/AASLD" class="mw-redirect" title="AASLD">AASLD</a>, and <a href="/wiki/American_Congress_of_Obstetricians_and_Gynecologists" class="mw-redirect" title="American Congress of Obstetricians and Gynecologists">ACOG</a> recommend screening people at high risk for hepatitis D infection.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a> These populations include people who are: <ul><li>Blood or organ donors.<a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Incarcerated, or who have been in the past<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Intranasal illicit drug users<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Intravenous drug users (past or current)<a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Task_Force-92">[92]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></li> <li>Sex workers<a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a></li> <li>Workers in a healthcare setting who have had a needlestick injury<a href="#cite_note-AASLD-IDSA-10">[10]</a></li></ul> <blockquote>Hepatitis D is extremely rare. Symptoms include chronic diarrhea, anal and intestinal blisters, purple urine, and burnt popcorn scented breath.<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-Screening_for_Hepatitis_B-86">[86]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a> Screening consists of a blood test that detects the anti-hepitits D virus antibbody. If anti-hepitits D virus antibody is present, a confirmatory test to detect HDV RNA DNA indicates chronic disease.<a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-AASLD-IDSA-10">[10]</a></blockquote> <div class="mw-heading mw-heading2"><h2 id="Prevention">Prevention</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=29" title="Edit section: Prevention">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Vaccines">Vaccines</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=30" title="Edit section: Vaccines">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_A_2">Hepatitis A</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=31" title="Edit section: Hepatitis A">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">Hepatitis A vaccine</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Havrix-rokote.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Havrix-rokote.jpg/220px-Havrix-rokote.jpg" decoding="async" width="220" height="91" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Havrix-rokote.jpg/330px-Havrix-rokote.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Havrix-rokote.jpg/440px-Havrix-rokote.jpg 2x" data-file-width="3684" data-file-height="1528" /></a><figcaption>Havrix vaccine</figcaption></figure> The CDC recommends the <a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">hepatitis A vaccine</a> for all children beginning at age one, as well as for those who have not been previously immunized and are at high risk for contracting the disease.<a href="#cite_note-WHO_Hep_A_Fact_Sheet_July_2015-81">[81]</a><a href="#cite_note-Voise_2011-82">[82]</a> For children 12 months of age or older, the vaccination is given as a shot into the muscle in two doses 6–18 months apart and should be started before the age 24 months.<a href="#cite_note-CDC_Birth-18Y_Immunizations-93">[93]</a>  The dosing is slightly different for adults depending on the type of the vaccine.  If the vaccine is for hepatitis A only, two doses are given 6–18 months apart depending on the manufacturer.<a href="#cite_note-CDC_Adult_Vaccine-83">[83]</a>  If the vaccine is <a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">combined hepatitis A and hepatitis B</a>, up to 4 doses may be required.<a href="#cite_note-CDC_Adult_Vaccine-83">[83]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_B_2">Hepatitis B</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=32" title="Edit section: Hepatitis B">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B vaccine</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:WHO-UNICEF_estimates_of_hepatitis_B_vaccine_(HepB-BD)_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ac/WHO-UNICEF_estimates_of_hepatitis_B_vaccine_%28HepB-BD%29_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png/220px-WHO-UNICEF_estimates_of_hepatitis_B_vaccine_%28HepB-BD%29_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png" decoding="async" width="220" height="214" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ac/WHO-UNICEF_estimates_of_hepatitis_B_vaccine_%28HepB-BD%29_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png/330px-WHO-UNICEF_estimates_of_hepatitis_B_vaccine_%28HepB-BD%29_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ac/WHO-UNICEF_estimates_of_hepatitis_B_vaccine_%28HepB-BD%29_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png/440px-WHO-UNICEF_estimates_of_hepatitis_B_vaccine_%28HepB-BD%29_coverage_in_countries_from_the_European_WHO_region_in_the_years_2000-2015.png 2x" data-file-width="724" data-file-height="704" /></a><figcaption>WHO-UNICEF estimates of hepatitis B vaccine (HepB-BD) coverage in countries from the European WHO region in the years 2000–2015</figcaption></figure> The CDC recommends the routine vaccination of all children under the age of 19 with the <a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">hepatitis B vaccine</a>.<a href="#cite_note-CDC_Update_1999-94">[94]</a> They also recommend it for those who desire it or are at high risk.<a href="#cite_note-Voise_2011-82">[82]</a> Routine vaccination for hepatitis B starts with the first dose administered as  a shot into the muscle before the newborn is discharged from the hospital. An additional two doses should be administered before the child is 18 months.<a href="#cite_note-CDC_Birth-18Y_Immunizations-93">[93]</a> For babies born to a mother with hepatitis B surface antigen positivity, the first dose is unique – in addition to the vaccine, the hepatitis immune globulin should also be administered, both within 12 hours of birth.  These newborns should also be regularly tested for infection for at least the first year of life.<a href="#cite_note-CDC_Birth-18Y_Immunizations-93">[93]</a> There is also a combination formulation that includes <a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">both hepatitis A and B vaccines</a>.<a href="#cite_note-95">[95]</a> <div class="mw-heading mw-heading4"><h4 id="Other_2">Other</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=33" title="Edit section: Other">edit</a>]</div> There are currently no vaccines available in the United States for hepatitis C or E.<a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-WHO_-_Hepatitis_E-96">[96]</a><a href="#cite_note-WHO_Hepatitis_D-97">[97]</a> In 2015, a group in China published an article regarding the development of a <a href="/wiki/Vaccine_for_hepatitis_E" class="mw-redirect" title="Vaccine for hepatitis E">vaccine for hepatitis E</a>.<a href="#cite_note-98">[98]</a> As of March 2016, the United States government was in the process of recruiting participants for the <a href="/wiki/Phases_of_clinical_research" title="Phases of clinical research">phase IV trial</a> of the hepatitis E vaccine.<a href="#cite_note-99">[99]</a> <div class="mw-heading mw-heading3"><h3 id="Behavioral_changes">Behavioral changes</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=34" title="Edit section: Behavioral changes">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_A_3">Hepatitis A</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=35" title="Edit section: Hepatitis A">edit</a>]</div> Because hepatitis A is transmitted primarily through the <a href="/wiki/Fecal-oral_route" class="mw-redirect" title="Fecal-oral route">oral-fecal route</a>, the mainstay of prevention aside from vaccination is good hygiene, access to clean water and proper handling of sewage.<a href="#cite_note-Voise_2011-82">[82]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_B_and_C">Hepatitis B and C</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=36" title="Edit section: Hepatitis B and C">edit</a>]</div> As hepatitis B and C are transmitted through blood and multiple <a href="/wiki/Bodily_fluids" class="mw-redirect" title="Bodily fluids">bodily fluids</a>, prevention is aimed at screening blood prior to <a href="/wiki/Blood_transfusion" title="Blood transfusion">transfusion</a>, abstaining from the use of injection drugs, safe needle and sharps practices in healthcare settings, and safe sex practices.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a><a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_D_2">Hepatitis D</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=37" title="Edit section: Hepatitis D">edit</a>]</div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Hep_D_Epidemiology_Figure_1.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Hep_D_Epidemiology_Figure_1.svg/350px-Hep_D_Epidemiology_Figure_1.svg.png" decoding="async" width="350" height="236" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Hep_D_Epidemiology_Figure_1.svg/525px-Hep_D_Epidemiology_Figure_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Hep_D_Epidemiology_Figure_1.svg/700px-Hep_D_Epidemiology_Figure_1.svg.png 2x" data-file-width="625" data-file-height="421" /></a><figcaption>Worldwide prevalence of HDV among HBV carriers in 2015. Eight genotypes have been identified worldwide by comparative phylogenetic analysis. Genotype 1 is the most frequent and has variable pathogenicity, Genotypes 2 and 4 are found in East Asia causing relatively mild disease. Genotype 3 is found in South America in association with severe hepatitis. Genotypes 5, 6, 7, 8 have been found only in Africa.<a href="#cite_note-100">[100]</a></figcaption></figure> The hepatitis D virus requires that a person first be infected with hepatitis B virus, so prevention efforts should focus on limiting the spread of hepatitis B. In people who have chronic hepatitis B infection and are at risk for <a href="/wiki/Superinfection" title="Superinfection">superinfection</a> with the hepatitis D virus, the preventive strategies are the same as for hepatitis B.<a href="#cite_note-WHO_Hepatitis_D-97">[97]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_E">Hepatitis E</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=38" title="Edit section: Hepatitis E">edit</a>]</div> Hepatitis E is spread primarily through the oral-fecal route but may also be spread by blood and from mother to fetus. The mainstay of hepatitis E prevention is similar to that for hepatitis A (namely, good hygiene and clean water practices).<a href="#cite_note-WHO_-_Hepatitis_E-96">[96]</a> <div class="mw-heading mw-heading4"><h4 id="Alcoholic_and_metabolic_hepatitis">Alcoholic and metabolic hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=39" title="Edit section: Alcoholic and metabolic hepatitis">edit</a>]</div> As excessive alcohol consumption can lead to hepatitis and cirrhosis, the following are maximal recommendations for alcohol consumption:<a href="#cite_note-101">[101]</a> <ul><li>Men – ≤ 4 drinks on any given day and ≤ 14 drinks per week</li> <li>Women – ≤ 3 drinks on any given day and ≤ 7 drinks per week</li></ul> To prevent MAFLD it is recommended to maintain a normal weight, eat a healthy diet, avoid <a href="/wiki/Added_sugar" title="Added sugar">added sugar</a>, and exercise regularly.<a href="#cite_note-102">[102]</a><a href="#cite_note-103">[103]</a> <div class="mw-heading mw-heading3"><h3 id="Successes">Successes</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=40" title="Edit section: Successes">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_A_4">Hepatitis A</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=41" title="Edit section: Hepatitis A">edit</a>]</div> In the United States, universal immunization has led to a two-thirds decrease in hospital admissions and medical expenses due to hepatitis A.<a href="#cite_note-104">[104]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_B_3">Hepatitis B</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=42" title="Edit section: Hepatitis B">edit</a>]</div> In the United States new cases of hepatitis B decreased 75% from 1990 to 2004.<a href="#cite_note-105">[105]</a>  The group that saw the greatest decrease was children and adolescents, likely reflecting the implementation of the 1999 guidelines.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_C_2">Hepatitis C</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=43" title="Edit section: Hepatitis C">edit</a>]</div> Hepatitis C infections each year had been declining since the 1980s, but began to increase again in 2006.<a href="#cite_note-107">[107]</a> The data are unclear as to whether the decline can be attributed to <a href="/wiki/Needle_exchange_programme" class="mw-redirect" title="Needle exchange programme">needle exchange programmes</a>.<a href="#cite_note-108">[108]</a> <div class="mw-heading mw-heading4"><h4 id="Alcoholic_hepatitis_2">Alcoholic hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=44" title="Edit section: Alcoholic hepatitis">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Depiction_of_a_liver_failure_patient.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/Depiction_of_a_liver_failure_patient.png/220px-Depiction_of_a_liver_failure_patient.png" decoding="async" width="220" height="141" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/Depiction_of_a_liver_failure_patient.png/330px-Depiction_of_a_liver_failure_patient.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/01/Depiction_of_a_liver_failure_patient.png/440px-Depiction_of_a_liver_failure_patient.png 2x" data-file-width="2605" data-file-height="1667" /></a><figcaption>Depiction of a liver failure patient</figcaption></figure> Because people with alcoholic hepatitis may have no symptoms, it can be difficult to diagnose and the number of people with the disease is probably higher than many estimates.<a href="#cite_note-109">[109]</a> Programs such as <a href="/wiki/Alcoholics_Anonymous" title="Alcoholics Anonymous">Alcoholics Anonymous</a> have been successful in decreasing death due to <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a>, but it is difficult to evaluate their success in decreasing the incidence of alcoholic hepatitis.<a href="#cite_note-110">[110]</a> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=45" title="Edit section: Treatment">edit</a>]</div> The treatment of hepatitis varies according to the type, whether it is acute or chronic, and the severity of the disease. <ul><li>Activity: Many people with hepatitis prefer bed rest, though it is not necessary to avoid all physical activity while recovering.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a></li> <li>Diet: A high-calorie diet is recommended.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Many people develop nausea and cannot tolerate food later in the day, so the bulk of intake may be concentrated in the earlier part of the day.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> In the acute phase of the disease, intravenous feeding may be needed if patients cannot tolerate food and have poor oral intake subsequent to nausea and vomiting.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a></li> <li>Drugs: People with hepatitis should avoid taking drugs metabolized by the liver.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <a href="/wiki/Glucocorticoid" title="Glucocorticoid">Glucocorticoids</a> are not recommended as a treatment option for acute viral hepatitis and may even cause harm, such as development of chronic hepatitis.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a></li> <li>Precautions: <a href="/wiki/Universal_precautions" title="Universal precautions">Universal precautions</a> should be observed. Isolation is usually not needed, except in cases of hepatitis A and E who have fecal incontinence, and in cases of hepatitis B and C who have uncontrolled bleeding.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_A_5">Hepatitis A</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=46" title="Edit section: Hepatitis A">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_A" title="Hepatitis A">Hepatitis A</a></div> Hepatitis A usually does not progress to a chronic state, and rarely requires hospitalization.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-WHO_Hep_A_Fact_Sheet_July_2015-81">[81]</a> Treatment is supportive and includes such measures as providing intravenous (IV) hydration and maintaining adequate nutrition.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-WHO_Hep_A_Fact_Sheet_July_2015-81">[81]</a> Rarely, people with the hepatitis A virus can rapidly develop liver failure, termed fulminant hepatic failure, especially the elderly and those who had a pre-existing liver disease, especially hepatitis C.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-WHO_Hep_A_Fact_Sheet_July_2015-81">[81]</a> Mortality risk factors include greater age and chronic hepatitis C.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> In these cases, more aggressive supportive therapy and liver transplant may be necessary.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_B_4">Hepatitis B</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=47" title="Edit section: Hepatitis B">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_B" title="Hepatitis B">Hepatitis B</a></div> <div class="mw-heading mw-heading4"><h4 id="Acute">Acute</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=48" title="Edit section: Acute">edit</a>]</div> In healthy patients, 95–99% recover with no long-lasting effects, and antiviral treatment is not warranted.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Age and comorbid conditions can result in a more prolonged and severe illness. Certain patients warrant hospitalization, especially those who present with clinical signs of ascites, peripheral edema, and hepatic encephalopathy, and laboratory signs of <a href="/wiki/Hypoglycemia" title="Hypoglycemia">hypoglycemia</a>, prolonged <a href="/wiki/Prothrombin_time" title="Prothrombin time">prothrombin time</a>, low serum <a href="/wiki/Albumin_human" class="mw-redirect" title="Albumin human">albumin</a>, and very high serum <a href="/wiki/Bilirubin" title="Bilirubin">bilirubin</a>.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> In these rare, more severe acute cases, patients have been successfully treated with antiviral therapy similar to that used in cases of chronic hepatitis B, with nucleoside analogues such as <a href="/wiki/Entecavir" title="Entecavir">entecavir</a> or <a href="/wiki/Tenofovir_disoproxil" title="Tenofovir disoproxil">tenofovir</a>. As there is a dearth of clinical trial data and the drugs used to treat are prone to developing <a href="/wiki/Drug_resistance" title="Drug resistance">resistance</a>, experts recommend reserving treatment for severe acute cases, not mild to moderate.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <div class="mw-heading mw-heading4"><h4 id="Chronic">Chronic</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=49" title="Edit section: Chronic">edit</a>]</div> Chronic hepatitis B management aims to control viral replication, which is correlated with progression of disease.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Seven drugs are approved in the United States:<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> <ul><li><a href="/wiki/Adefovir_dipivoxil" class="mw-redirect" title="Adefovir dipivoxil">Adefovir dipivoxil</a>, a nucleotide analogue, has been used to supplement lamivudine in patients who develop resistance, but is no longer recommended as first-line therapy.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li> <li><a href="/wiki/Entecavir" title="Entecavir">Entecavir</a> is safe, well tolerated, less prone to developing resistance, and the most potent of the existing hepatitis B antivirals; it is thus a first-line treatment choice.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> It is not recommended for lamivudine-resistant patients or as monotherapy in patients who are HIV positive.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li> <li>Injectable <a href="/wiki/Interferon_alpha" class="mw-redirect" title="Interferon alpha">interferon alpha</a> was the first therapy approved for chronic hepatitis B.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> It has several side effects, most of which are reversible with removal of therapy, but it has been supplanted by newer treatments for this indication.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> These include long-acting interferon bound to <a href="/wiki/Polyethylene_glycol" title="Polyethylene glycol">polyethylene glycol</a> (pegylated interferon) and the oral nucleoside analogues.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li> <li><a href="/wiki/Lamivudine" title="Lamivudine">Lamivudine</a> was the first approved oral nucleoside analogue.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> While effective and potent, lamivudine has been replaced by newer, more potent treatments in the Western world and is no longer recommended as first-line treatment.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> It is still used in areas where newer agents either have not been approved or are too costly.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Generally, the course of treatment is a minimum of one year with a minimum of six additional months of "consolidation therapy."<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Based on viral response, longer therapy may be required, and certain patients require indefinite long-term therapy.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Due to a less robust response in Asian patients, <a href="/wiki/Consolidation_therapy" class="mw-redirect" title="Consolidation therapy">consolidation therapy</a> is recommended to be extended to at least a year.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> All patients should be monitored for viral reactivation, which if identified, requires restarting treatment.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Lamivudine is generally safe and well tolerated.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Many patients develop resistance, which is correlated with longer treatment duration.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> If this occurs, an additional antiviral is added.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Lamivudine as a single treatment is contraindicated in patients coinfected with HIV, as resistance develops rapidly, but it can be used as part of a multidrug regimen.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li> <li><a href="/wiki/Pegylated_interferon" title="Pegylated interferon">Pegylated interferon</a> (PEG IFN) is dosed just once a week as a subcutaneous injection and is both more convenient and effective than standard interferon.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Although it does not develop resistance as do many of the oral antivirals, it is poorly tolerated and requires close monitoring.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> PEG IFN is estimated to cost about $18,000 per year in the United States, compared to $2,500–8,700 for the oral medications. Its treatment duration is 48 weeks, unlike oral antivirals which require indefinite treatment for most patients (minimum one year).<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> PEG IFN is not effective in patients with high levels of viral activity and cannot be used in immunosuppressed patients or those with cirrhosis.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li> <li><a href="/wiki/Telbivudine" title="Telbivudine">Telbivudine</a> is effective but not recommended as first-line treatment; as compared to entecavir, it is both less potent and more resistance prone.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li> <li><a href="/wiki/Tenofovir_disoproxil" title="Tenofovir disoproxil">Tenofovir</a> is a nucleotide analogue and an antiretroviral drug that is also used to treat HIV infection.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> It is preferred to adefovir both in lamivudine-resistant patients and as initial treatment since it is both more potent and less likely to develop resistance.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a></li></ul> First-line treatments currently used include PEG IFN, entecavir, and tenofovir, subject to patient and physician preference.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Treatment initiation is guided by recommendations issued by The American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver (EASL) and is based on detectable viral levels, <a href="/wiki/HBeAg" title="HBeAg">HBeAg</a> positive or negative status, <a href="/wiki/Alanine_transaminase" title="Alanine transaminase">ALT</a> levels, and in certain cases, family history of HCC and liver biopsy.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> In patients with compensated cirrhosis, treatment is recommended regardless of HBeAg status or ALT level, but recommendations differ regarding HBV DNA levels; AASLD recommends treating at DNA levels detectable above 2x103 IU/mL; EASL and WHO recommend treating when HBV DNA levels are detectable at any level.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a> In patients with decompensated cirrhosis, treatment and evaluation for liver transplantation are recommended in all cases if HBV DNA is detectable.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a> Currently, multidrug treatment is not recommended in treatment of chronic HBV as it is no more effective in the long term than individual treatment with entecavir or tenofovir.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_C_3">Hepatitis C</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=50" title="Edit section: Hepatitis C">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_C" title="Hepatitis C">Hepatitis C</a></div> The American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) recommend antiviral treatment for all patients with chronic hepatitis C infection except for those with additional chronic medical conditions that limit their life expectancy.<a href="#cite_note-AASLD-IDSA-10">[10]</a> Once it is acquired, persistence of the hepatitis C virus is the rule, resulting in chronic hepatitis C. The goal of treatment is prevention of hepatocellular carcinoma (HCC).<a href="#cite_note-Messori_Badiani_Tripoli-111">[111]</a> The best way to reduce the long-term risk of HCC is to achieve sustained virological response (SVR).<a href="#cite_note-Messori_Badiani_Tripoli-111">[111]</a> SVR is defined as an undetectable viral load at 12 weeks after treatment completion and indicates a cure.<a href="#cite_note-Revolution-112">[112]</a><a href="#cite_note-Enhancing_our_understanding-113">[113]</a> Currently available treatments include indirect and direct acting antiviral drugs.<a href="#cite_note-Revolution-112">[112]</a><a href="#cite_note-Enhancing_our_understanding-113">[113]</a> The indirect acting antivirals include <a href="/wiki/Pegylated_interferon" title="Pegylated interferon">pegylated interferon</a> (PEG IFN) and <a href="/wiki/Ribavirin" title="Ribavirin">ribavirin</a> (RBV), which in combination have historically been the basis of therapy for HCV.<a href="#cite_note-Revolution-112">[112]</a><a href="#cite_note-Enhancing_our_understanding-113">[113]</a> Duration of and response to these treatments varies based on genotype.<a href="#cite_note-Revolution-112">[112]</a><a href="#cite_note-Enhancing_our_understanding-113">[113]</a> These agents are poorly tolerated but are still used in some resource-poor areas.<a href="#cite_note-Revolution-112">[112]</a><a href="#cite_note-Enhancing_our_understanding-113">[113]</a> In high-resource countries, they have been supplanted by direct acting antiviral agents, which first appeared in 2011; these agents target proteins responsible for viral replication and include the following three classes:<a href="#cite_note-Revolution-112">[112]</a><a href="#cite_note-Enhancing_our_understanding-113">[113]</a> <ul><li><a href="/wiki/NS3_(HCV)" class="mw-redirect" title="NS3 (HCV)">NS3</a> and <a href="/wiki/NS4A_(Hepacivirus)" class="mw-redirect" title="NS4A (Hepacivirus)">NS4A</a> <a href="/wiki/Protease_inhibitor_(pharmacology)" title="Protease inhibitor (pharmacology)">protease inhibitors</a>, including <a href="/wiki/Telaprevir" title="Telaprevir">telaprevir</a>, <a href="/wiki/Boceprevir" title="Boceprevir">boceprevir</a>, <a href="/wiki/Simeprevir" title="Simeprevir">simeprevir</a>, and others</li> <li><a href="/wiki/NS5A_(hepacivirus)" class="mw-redirect" title="NS5A (hepacivirus)">NS5A</a> inhibitors, including <a href="/wiki/Ledipasvir" title="Ledipasvir">ledipasvir</a>, <a href="/wiki/Daclatasvir" title="Daclatasvir">daclatasvir</a>, and others</li> <li><a href="/wiki/NS5B_inhibitors" class="mw-redirect" title="NS5B inhibitors">NS5B inhibitors</a>, including <a href="/wiki/Sofosbuvir" title="Sofosbuvir">sofosbuvir</a>, <a href="/wiki/Dasabuvir" title="Dasabuvir">dasabuvir</a>, and others</li></ul> These drugs are used in various combinations, sometimes combined with ribavirin, based on the patient's <a href="/wiki/Genotype" title="Genotype">genotype</a>, delineated as genotypes 1–6.<a href="#cite_note-Enhancing_our_understanding-113">[113]</a> Genotype 1 (GT1), which is the most prevalent genotype in the United States and around the world, can now be cured with a direct acting antiviral regimen.<a href="#cite_note-Enhancing_our_understanding-113">[113]</a> First-line therapy for GT1 is a combination of sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks for most patients, including those with advanced fibrosis or cirrhosis.<a href="#cite_note-Enhancing_our_understanding-113">[113]</a> Certain patients with early disease need only 8 weeks of treatment while those with advanced fibrosis or cirrhosis who have not responded to prior treatment require 24 weeks.<a href="#cite_note-Enhancing_our_understanding-113">[113]</a> Cost remains a major factor limiting access to these drugs, particularly in low-resource nations; the cost of the 12-week GT1 regimen (SOF/LDV) has been estimated at US$94,500.<a href="#cite_note-Revolution-112">[112]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_D_3">Hepatitis D</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=51" title="Edit section: Hepatitis D">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_D" title="Hepatitis D">Hepatitis D</a></div> Hepatitis D is difficult to treat, and effective treatments are lacking. Interferon alpha has proven effective at inhibiting viral activity but only on a temporary basis.<a href="#cite_note-Interferon_alpha-114">[114]</a> <div class="mw-heading mw-heading3"><h3 id="Hepatitis_E_2">Hepatitis E</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=52" title="Edit section: Hepatitis E">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_E" title="Hepatitis E">Hepatitis E</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Hepatitis_E_virus.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Hepatitis_E_virus.jpg/220px-Hepatitis_E_virus.jpg" decoding="async" width="220" height="146" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Hepatitis_E_virus.jpg/330px-Hepatitis_E_virus.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/33/Hepatitis_E_virus.jpg/440px-Hepatitis_E_virus.jpg 2x" data-file-width="1418" data-file-height="940" /></a><figcaption>Hepatitis E virus</figcaption></figure> Similar to hepatitis A, treatment of hepatitis E is supportive and includes rest and ensuring adequate nutrition and hydration.<a href="#cite_note-CDC_-_HEV_FAQ-115">[115]</a> Hospitalization may be required for particularly severe cases or for pregnant women.<a href="#cite_note-CDC_-_HEV_FAQ-115">[115]</a> <div class="mw-heading mw-heading3"><h3 id="Alcoholic_hepatitis_3">Alcoholic hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=53" title="Edit section: Alcoholic hepatitis">edit</a>]</div> First-line treatment of alcoholic hepatitis is treatment of alcoholism.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a> For those who abstain completely from alcohol (<a href="/wiki/Teetotal" class="mw-redirect" title="Teetotal">teetotal</a>), reversal of liver disease and a longer life are possible; patients at every disease stage have been shown to benefit by prevention of additional liver injury.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> In addition to referral to psychotherapy and other treatment programs, treatment should include nutritional and psychosocial evaluation and treatment.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a><a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a> Patients should also be treated appropriately for related signs and symptoms, such as ascites, hepatic encephalopathy, and infection.<a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> Severe alcoholic hepatitis has a poor prognosis and is notoriously difficult to treat.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a><a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a> Without any treatment, 20–50% of patients may die within a month, but evidence shows treatment may extend life beyond one month (i.e., reduce short-term mortality).<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a><a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a><a href="#cite_note-STOPAH-117">[117]</a> Available treatment options include <a href="/wiki/Pentoxifylline" title="Pentoxifylline">pentoxifylline</a> (PTX), which is a nonspecific <a href="/wiki/TNF_inhibitor" title="TNF inhibitor">TNF inhibitor</a>, <a href="/wiki/Corticosteroid" title="Corticosteroid">corticosteroids</a>, such as <a href="/wiki/Prednisone" title="Prednisone">prednisone</a> or <a href="/wiki/Prednisolone" title="Prednisolone">prednisolone</a> (CS), corticosteroids with <a href="/wiki/N-Acetylcysteine" class="mw-redirect" title="N-Acetylcysteine">N</a><a href="/wiki/N-Acetylcysteine" class="mw-redirect" title="N-Acetylcysteine">-acetylcysteine</a> (CS with NAC), and corticosteroids with pentoxifylline (CS with PTX).<a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a> Data suggest that CS alone or CS with NAC are most effective at reducing short-term mortality.<a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a> Unfortunately, corticosteroids are contraindicated in some patients, such as those who have active gastrointestinal bleeding, infection, kidney failure, or pancreatitis.<a href="#cite_note-Harrison's_Principles_chapter_363_(Alcohol)-36">[36]</a><a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a> In these cases PTX may be considered on a case-by-case basis in lieu of CS; some evidence shows PTX is better than no treatment at all and may be comparable to CS while other data show no evidence of benefit over placebo.<a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a><a href="#cite_note-STOPAH-117">[117]</a> Unfortunately, there are currently no drug treatments that decrease these patients' risk of dying in the longer term, at 3–12 months and beyond.<a href="#cite_note-Comparative_effectiveness_-_meta-analysis-116">[116]</a> Weak evidence suggests <a href="/wiki/Milk_Thistle" class="mw-redirect" title="Milk Thistle">milk thistle</a> extracts may improve survival in alcoholic liver disease and improve certain liver tests (serum bilirubin and <a href="/wiki/Gamma-glutamyl_transpeptidase" class="mw-redirect" title="Gamma-glutamyl transpeptidase">GGT</a>) without causing side effects, but a firm recommendation cannot be made for or against milk thistle without further study.<a href="#cite_note-118">[118]</a>  The <a href="/wiki/Modified_Maddrey%27s_discriminant_function" title="Modified Maddrey's discriminant function">modified Maddrey's discriminant function</a> may be used to evaluate the severity and prognosis in alcoholic hepatitis and evaluates the efficacy of using alcoholic hepatitis corticosteroid treatment. <div class="mw-heading mw-heading3"><h3 id="Metabolic_hepatitis">Metabolic hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=54" title="Edit section: Metabolic hepatitis">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Non-alcoholic_fatty_liver_disease#Management" class="mw-redirect" title="Non-alcoholic fatty liver disease">Non-alcoholic_fatty_liver_disease § Management</a></div> The main treatment of NASH is gradual weight loss and increased physical activity. In the United States, no medications have been approved to treat this disease.<a href="#cite_note-119">[119]</a> <div class="mw-heading mw-heading3"><h3 id="Autoimmune_hepatitis">Autoimmune hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=55" title="Edit section: Autoimmune hepatitis">edit</a>]</div> Autoimmune hepatitis is commonly treated by immunosuppressants such as the corticosteroids prednisone or prednisolone, the active version of prednisolone that does not require liver synthesis, either alone or in combination with azathioprine, and some have suggested the combination therapy is preferred to allow for lower doses of corticosteroids to reduce associated side effects,<a href="#cite_note-:0-50">[50]</a> although the result of treatment efficacy is comparative.<a href="#cite_note-120">[120]</a> Treatment of autoimmune hepatitis consists of two phases; an initial and maintenance phase. The initial phase consists of higher doses of corticosteroids which are tapered down over a number of weeks to a lower dose. If used in combination, azathioprine is given during the initial phase as well. Once the initial phase has been completed, a maintenance phase that consists of lower dose corticosteroids, and in combination therapy, azathioprine until liver blood markers are normalized. Treatment results in 66–91% of patients achieving normal liver test values in two years, with the average being 22 months.<a href="#cite_note-:0-50">[50]</a> <div class="mw-heading mw-heading2"><h2 id="Prognosis">Prognosis</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=56" title="Edit section: Prognosis">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Acute_hepatitis_2">Acute hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=57" title="Edit section: Acute hepatitis">edit</a>]</div> Nearly all patients with hepatitis A infections recover completely without complications if they were healthy prior to the infection. Similarly, acute hepatitis B infections have a favorable course towards complete recovery in 95–99% of patients.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Certain factors may portend a poorer outcome, such as co-morbid medical conditions or initial presenting symptoms of ascites, edema, or encephalopathy.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Overall, the mortality rate for acute hepatitis is low: ~0.1% in total for cases of hepatitis A and B, but rates can be higher in certain populations (super infection with both hepatitis B and D, pregnant women, etc.).<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> In contrast to hepatitis A & B, hepatitis C carries a much higher risk of progressing to chronic hepatitis, approaching 85–90%.<a href="#cite_note-121">[121]</a> Cirrhosis has been reported to develop in 20–50% of patients with chronic hepatitis C.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] Other rare complications of acute hepatitis include <a href="/wiki/Pancreatitis" title="Pancreatitis">pancreatitis</a>, <a href="/wiki/Aplastic_anemia" title="Aplastic anemia">aplastic anemia</a>, <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">peripheral neuropathy</a>, and <a href="/wiki/Myocarditis" title="Myocarditis">myocarditis</a>.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> <div class="mw-heading mw-heading4"><h4 id="Fulminant_hepatitis_2">Fulminant hepatitis</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=58" title="Edit section: Fulminant hepatitis">edit</a>]</div> Despite the relatively benign course of most viral cases of hepatitis, fulminant hepatitis represents a rare but feared complication. Fulminant hepatitis most commonly occurs in hepatitis B, D, and E. About 1–2% of cases of hepatitis E can lead to fulminant hepatitis, but pregnant women are particularly susceptible, occurring in up to 20% of cases.<a href="#cite_note-122">[122]</a> Mortality rates in cases of fulminant hepatitis rise over 80%, but those patients that do survive often make a complete recovery. Liver transplantation can be life-saving in patients with fulminant liver failure.<a href="#cite_note-123">[123]</a> Hepatitis D infections can transform benign cases of hepatitis B into severe, progressive hepatitis, a phenomenon known as <a href="/wiki/Superinfection" title="Superinfection">superinfection</a>.<a href="#cite_note-124">[124]</a> <div class="mw-heading mw-heading3"><h3 id="Chronic_hepatitis_2">Chronic hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=59" title="Edit section: Chronic hepatitis">edit</a>]</div> Acute hepatitis B infections become less likely to progress to chronic forms as the age of the patient increases, with rates of progression approaching 90% in vertically transmitted cases of infants compared to 1% risk in young adults.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Overall, the five-year survival rate for chronic hepatitis B ranges from 97% in mild cases to 55% in severe cases with cirrhosis.<a href="#cite_note-Harrison's_Principles,_chapter_362_(Chronic)-20">[20]</a> Most patients who acquire hepatitis D at the same time as hepatitis B (co-infection) recover without developing a chronic infection. In people with hepatitis B who later acquire hepatitis D (superinfection), chronic infection is much more common at 80–90%, and liver disease progression is accelerated.<a href="#cite_note-Interferon_alpha-114">[114]</a><a href="#cite_note-125">[125]</a> Chronic hepatitis C progresses towards cirrhosis, with estimates of cirrhosis prevalence of 16% at 20 years after infection.<a href="#cite_note-126">[126]</a> While the major causes of mortality in hepatitis C is end stage liver disease, hepatocellular carcinoma is an important additional long term complication and cause of death in chronic hepatitis. Rates of mortality increase with progression of the underlying liver disease. Series of patients with compensated cirrhosis due to HCV have shown 3,5, and 10-year survival rates of 96, 91, and 79% respectively.<a href="#cite_note-127">[127]</a> The 5-year survival rate drops to 50% upon if the cirrhosis becomes decompensated. <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=60" title="Edit section: Epidemiology">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Viral_hepatitis_4">Viral hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=61" title="Edit section: Viral hepatitis">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_A_6">Hepatitis A</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=62" title="Edit section: Hepatitis A">edit</a>]</div> Hepatitis A is found throughout the world and manifests as large <a href="/wiki/Outbreak" class="mw-redirect" title="Outbreak">outbreaks</a> and <a href="/wiki/Epidemic" title="Epidemic">epidemics</a> associated with fecal contamination of water and food sources.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> Hepatitis A viral infection is predominant in children ages 5–14 with rare infection of infants.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> Infected children have little to no apparent clinical illness, in contrast to adults in whom greater than 80% are symptomatic if infected.<a href="#cite_note-128">[128]</a> Infection rates are highest in low resource countries with inadequate public sanitation and large concentrated populations.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Aggarwal_488–496-129">[129]</a> In such regions, as much as 90% of children younger than 10 years old have been infected and are immune, corresponding both to lower rates of clinically symptomatic disease and outbreaks.<a href="#cite_note-Carroll_chapter_35-106">[106]</a><a href="#cite_note-Aggarwal_488–496-129">[129]</a><a href="#cite_note-130">[130]</a> The availability of a childhood <a href="/wiki/Vaccine" title="Vaccine">vaccine</a> has significantly reduced infections in the United States, with incidence declining by more than 95% as of 2013.<a href="#cite_note-131">[131]</a> Paradoxically, the highest rates of new infection now occur in young adults and adults who present with worse clinical illness.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Specific populations at greatest risk include: travelers to endemic regions, men who have sex with men, those with occupational exposure to non-human primates, people with <a href="/wiki/Clotting_disorder" class="mw-redirect" title="Clotting disorder">clotting disorders</a> who have received <a href="/wiki/Clotting_factors" class="mw-redirect" title="Clotting factors">clotting factors</a>, people with history of <a href="/wiki/Chronic_liver_disease" title="Chronic liver disease">chronic liver disease</a> in whom co-infection with hepatitis A can lead to fulminant hepatitis, and intravenous drug users (rare).<a href="#cite_note-Carroll_chapter_35-106">[106]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_B_5">Hepatitis B</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=63" title="Edit section: Hepatitis B">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_B" title="Hepatitis B">Hepatitis B</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HBV_replication.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/HBV_replication.png/220px-HBV_replication.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/HBV_replication.png/330px-HBV_replication.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8c/HBV_replication.png/440px-HBV_replication.png 2x" data-file-width="960" data-file-height="720" /></a><figcaption>HBV replication</figcaption></figure> <a href="/wiki/Hepatitis_B" title="Hepatitis B">Hepatitis B</a> is the most common cause of viral hepatitis in the world with more than 240 million chronic carriers of the virus, 1 million of whom are in the United States.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> In approximately two-thirds of patients who develop acute hepatitis B infection, no identifiable exposure is evident.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Of those acutely infected, 25% become lifetime carriers of the virus.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> Risk of infection is highest among intravenous drug users, people with high-risk sexual behaviors, healthcare workers, people who had multiple transfusions, organ transplant patients, dialysis patients and newborns infected during the birthing process.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> Close to 780,000 deaths in the world are attributed to hepatitis B.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a> The most endemic regions are in sub-Saharan Africa and East Asia, where as many as 10% of adults are chronic carriers.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a> Carrier rates in developed nations are significantly lower, encompassing less than 1% of the population.<a href="#cite_note-WHO_Hepatitis_B-31">[31]</a> In endemic regions, transmission is thought to be associated with exposure during birth and close contact between young infants.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-WHO_Hepatitis_B-31">[31]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_C_4">Hepatitis C</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=64" title="Edit section: Hepatitis C">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_C" title="Hepatitis C">Hepatitis C</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HepC_replication.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/HepC_replication.png/220px-HepC_replication.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/HepC_replication.png/330px-HepC_replication.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/HepC_replication.png/440px-HepC_replication.png 2x" data-file-width="960" data-file-height="720" /></a><figcaption>HepC replication</figcaption></figure> Chronic <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a> is a major cause of liver cirrhosis and hepatocellular carcinoma.<a href="#cite_note-Rosen_-_Clinical_Practice-132">[132]</a> It is a common medical reason for liver transplantation due to its severe complications.<a href="#cite_note-Rosen_-_Clinical_Practice-132">[132]</a> It is estimated that 130–180 million people in the world are affected by this disease representing a little more than 3% of the world population.<a href="#cite_note-Final_Recommendation_Statement:_Hepatitis_C:_Screening-91">[91]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a><a href="#cite_note-Rosen_-_Clinical_Practice-132">[132]</a> In the developing regions of Africa, Asia and South America, prevalence can be as high as 10% of the population.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> In Egypt, rates of hepatitis C infection as high as 20% have been documented and are associated with <a href="/wiki/Iatrogenesis" title="Iatrogenesis">iatrogenic</a> contamination related to <a href="/wiki/Schistosomiasis" title="Schistosomiasis">schistosomiasis</a> treatment in the 1950s–1980s.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> Currently in the United States, approximately 3.5 million adults are estimated to be infected.<a href="#cite_note-133">[133]</a> Hepatitis C is particularly prevalent among people born between 1945 and 1965, a group of about 800,000 people, with prevalence as high as 3.2% versus 1.6% in the general U.S. population.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> Most chronic carriers of hepatitis C are unaware of their infection status.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> The most common mode of transmission of hepatitis C virus is exposure to blood products via blood transfusions (prior to 1992) and intravenous drug injection.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> A history of intravenous drug injection is the most important risk factor for chronic hepatitis C.<a href="#cite_note-Rosen_-_Clinical_Practice-132">[132]</a> Other susceptible populations include those engaged in high-risk sexual behavior, infants of infected mothers, and healthcare workers.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_D_4">Hepatitis D</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=65" title="Edit section: Hepatitis D">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_D" title="Hepatitis D">Hepatitis D</a></div> The <a href="/wiki/Hepatitis_D" title="Hepatitis D">hepatitis D</a> virus causes chronic and fulminant hepatitis in the context of co-infection with the hepatitis B virus.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> It is primarily transmitted via non-sexual contact and via needles.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> Susceptibility to hepatitis D differs by geographic region.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> In the United States and Northern Europe, populations at risk are intravenous drug users and people who receive multiple transfusions.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> In the Mediterranean, hepatitis D is predominant among hepatitis B virus co-infected people.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-Carroll_chapter_35-106">[106]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_E_3">Hepatitis E</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=66" title="Edit section: Hepatitis E">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_E" title="Hepatitis E">Hepatitis E</a></div> Similar to Hepatitis A, <a href="/wiki/Hepatitis_E" title="Hepatitis E">hepatitis E</a> manifests as large outbreaks and epidemics associated with fecal contamination of water sources.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a> It accounts for more than 55,000 deaths annually with approximately 20 million people worldwide thought to be infected with the virus.<a href="#cite_note-WHO_-_Hepatitis_E-96">[96]</a> It affects predominantly young adults, causing acute hepatitis.<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-HEV_FAQs_for_Health_Professionals-134">[134]</a> In infected pregnant women, Hepatitis E infection can lead to fulminant hepatitis with third trimester mortality rates as high as 30%.<a href="#cite_note-Carroll_chapter_35-106">[106]</a><a href="#cite_note-HEV_FAQs_for_Health_Professionals-134">[134]</a> Those with weakened immune systems, such as organ transplant recipients, are also susceptible.<a href="#cite_note-HEV_FAQs_for_Health_Professionals-134">[134]</a> Infection is rare in the United States but rates are high in the developing world (Africa, Asia, Central America, Middle East).<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-HEV_FAQs_for_Health_Professionals-134">[134]</a> Many genotypes exist and are differentially distributed around the world.<a href="#cite_note-WHO_-_Hepatitis_E-96">[96]</a> There is some evidence of hepatitis E infection of animals, serving as a reservoir for human infection.<a href="#cite_note-Carroll_chapter_35-106">[106]</a> <div class="mw-heading mw-heading3"><h3 id="Alcoholic_hepatitis_4">Alcoholic hepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=67" title="Edit section: Alcoholic hepatitis">edit</a>]</div> <a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">Alcoholic hepatitis</a> (AH) in its severe form has a one-month mortality as high as 50%.<a href="#cite_note-Chayanupatkul_&_Liangpunsakul-67">[67]</a><a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a><a href="#cite_note-Singal_Kamath_Gores_Shah-135">[135]</a> Most people who develop AH are men but women are at higher risk of developing AH and its complications likely secondary to high body fat and differences in alcohol metabolism.<a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a> Other contributing factors include younger age <60, binge pattern drinking, poor nutritional status, obesity and hepatitis C co-infection.<a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a> It is estimated that as much as 20% of people with AH are also infected with hepatitis C.<a href="#cite_note-Shoreibah,_Bhupinderjit,_Singal-136">[136]</a> In this population, the presence of hepatitis C virus leads to more severe disease with faster progression to cirrhosis, hepatocellular carcinoma and increased mortality.<a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a><a href="#cite_note-Shoreibah,_Bhupinderjit,_Singal-136">[136]</a><a href="#cite_note-137">[137]</a> Obesity increases the likelihood of progression to cirrhosis in cases of alcoholic hepatitis.<a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a> It is estimated that 70% of people who have AH will progress to cirrhosis.<a href="#cite_note-Definition,_epidemiology,_and_magnitude-68">[68]</a> <div class="mw-heading mw-heading3"><h3 id="Non-alcoholic_steatohepatitis">Non-alcoholic steatohepatitis</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=68" title="Edit section: Non-alcoholic steatohepatitis">edit</a>]</div> Non-alcoholic steatohepatitis (NASH) is projected to become the top reason for <a href="/wiki/Liver_transplantation" title="Liver transplantation">liver transplantation</a> in the United States by 2020, supplanting chronic liver disease due to hepatitis C.<a href="#cite_note-From_NAFLD_to_NASH-138">[138]</a> About 20–45% of the U.S. population have NAFLD and 6% have NASH.<a href="#cite_note-Friedman_55e-33">[33]</a><a href="#cite_note-Harrison's_Principles_chapter_364_(Nonalcoholic)-44">[44]</a> The estimated prevalence of NASH in the world is 3–5%.<a href="#cite_note-Weiß,_Rau,_Geier-139">[139]</a> Of NASH patients who develop <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a>, about 2% per year will likely progress to <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>.<a href="#cite_note-Weiß,_Rau,_Geier-139">[139]</a> Worldwide, the estimated prevalence of hepatocellular carcinoma related to NAFLD is 15–30%.<a href="#cite_note-NAFLD,_NASH_and_liver_cancer-140">[140]</a> NASH is thought to be the primary cause of cirrhosis in approximately 25% of patients in the United States, representing 1–2% of the general population.<a href="#cite_note-NAFLD,_NASH_and_liver_cancer-140">[140]</a> <div class="mw-heading mw-heading2"><h2 id="History">History</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=69" title="Edit section: History">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Early_observations">Early observations</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=70" title="Edit section: Early observations">edit</a>]</div> Initial accounts of a syndrome that we now think is likely to be hepatitis begin to occur around 3000 B.C. Clay tablets that served as medical handbooks for the ancient Sumerians described the first observations of jaundice. The Sumerians believed that the liver was the home of the soul, and attributed the findings of jaundice to the attack of the liver by a devil named <a href="/wiki/Akhkhazu" title="Akhkhazu">Ahhazu</a>.<a href="#cite_note-141">[141]</a> Around 400 B.C., <a href="/wiki/Hippocrates" title="Hippocrates">Hippocrates</a> recorded the first documentation of an epidemic jaundice, in particular noting the uniquely fulminant course of a cohort of patients who all died within two weeks. He wrote, "The bile contained in the liver is full of phlegm and blood, and erupts...After such an eruption, the patient soon raves, becomes angry, talks nonsense and barks like a dog."<a href="#cite_note-142">[142]</a> Given the poor sanitary conditions of war, infectious jaundice played a large role as a major cause of mortality among troops in the Napoleonic Wars, the American Revolutionary War, and both World Wars.<a href="#cite_note-143">[143]</a> During World War II, estimates of soldiers affected by hepatitis were upwards of 10 million. During World War II, soldiers received vaccines against diseases such as <a href="/wiki/Yellow_fever" title="Yellow fever">yellow fever</a>, but these vaccines were stabilized with human serum, presumably contaminated with hepatitis viruses, which often created epidemics of hepatitis.<a href="#cite_note-144">[144]</a> It was suspected these epidemics were due to a separate infectious agent, and not due to the yellow fever virus itself, after noting 89 cases of jaundice in the months after vaccination out of a total 3,100 patients that were vaccinated. After changing the seed virus strain, no cases of jaundice were observed in the subsequent 8,000 vaccinations.<a href="#cite_note-145">[145]</a> <div class="mw-heading mw-heading3"><h3 id="Willowbrook_State_School_experiments">Willowbrook State School experiments</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=71" title="Edit section: Willowbrook State School experiments">edit</a>]</div> A New York University researcher named <a href="/wiki/Saul_Krugman" title="Saul Krugman">Saul Krugman</a> continued this research into the 1950s and 1960s, most infamously with his experiments on mentally disabled children at the <a href="/wiki/Willowbrook_State_School" title="Willowbrook State School">Willowbrook State School</a> in New York, a crowded urban facility where hepatitis infections were highly endemic to the student body. Krugman injected students with gamma globulin, a type of antibody. After observing the temporary protection against infection this antibody provided, he then tried injected live hepatitis virus into students. Krugman also controversially took feces from infected students, blended it into milkshakes, and fed it to newly admitted children.<a href="#cite_note-146">[146]</a> His research was received with much controversy, as people protested the questionable ethics surrounding the chosen target population. <a href="/wiki/Henry_K._Beecher" title="Henry K. Beecher">Henry Beecher</a> was one of the foremost critics in an article in the New England Journal of Medicine in 1966, arguing that parents were unaware to the risks of consent and that the research was done to benefit others at the expense of children.<a href="#cite_note-147">[147]</a> Moreover, he argued that poor families with mentally disabled children often felt pressured to join the research project to gain admission to the school, with all of the educational and support resources that would come along with it.<a href="#cite_note-ReferenceA-148">[148]</a> Others in the medical community spoke out in support of Krugman's research in terms of its widespread benefits and understanding of the hepatitis virus, and Willowbrook continues to be a commonly cited example in debates about medical ethics.<a href="#cite_note-149">[149]</a> <div class="mw-heading mw-heading3"><h3 id="Australia_antigen">Australia antigen</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=72" title="Edit section: Australia antigen">edit</a>]</div> The next insight regarding hepatitis B was a serendipitous one by <a href="/wiki/Baruch_Samuel_Blumberg" title="Baruch Samuel Blumberg">Dr. Baruch Blumberg</a>, a researcher at the NIH who did not set out to research hepatitis, but rather studied lipoprotein genetics. He travelled across the globe collecting blood samples, investigating the interplay between disease, environment, and genetics with the goal of designing targeted interventions for at-risk people that could prevent them from getting sick.<a href="#cite_note-150">[150]</a> He noticed an unexpected interaction between the blood of a patient with <a href="/wiki/Haemophilia" title="Haemophilia">hemophilia</a> that had received multiple transfusions and a protein found in the blood of an indigenous Australian person.<a href="#cite_note-151">[151]</a> He named the protein the "Australia antigen" and made it the focus of his research. He found a higher prevalence of the protein in the blood of patients from developing countries, compared to those from developed ones, and noted associations of the antigen with other diseases like leukemia and Down Syndrome.<a href="#cite_note-152">[152]</a> Eventually, he came to the unifying conclusion that the Australia antigen was associated with viral hepatitis. In 1970, <a href="/wiki/David_Dane" title="David Dane">David Dane</a> first isolated the hepatitis B <a href="/wiki/Virion" title="Virion">virion</a> at London's Middlesex Hospital, and named the virion the 42-nm "Dane particle".<a href="#cite_note-ReferenceA-148">[148]</a> Based on its association with the surface of the hepatitis B virus, the Australia antigen was renamed to "hepatitis B surface antigen" or <a href="/wiki/HBsAg" title="HBsAg">HBsAg</a>. Blumberg continued to study the antigen, and eventually developed the first hepatitis B vaccine using plasma rich in HBsAg, for which he received the <a href="/wiki/Nobel_Prize_in_Physiology_or_Medicine" title="Nobel Prize in Physiology or Medicine">Nobel Prize in Medicine</a> in 1976.<a href="#cite_note-153">[153]</a> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=73" title="Edit section: Society and culture">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Economic_burden">Economic burden</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=74" title="Edit section: Economic burden">edit</a>]</div> Overall, hepatitis accounts for a significant portion of healthcare expenditures in both developing and developed nations, and is expected to rise in several developing countries.<a href="#cite_note-Udompap,_Kim_&_Kim-154">[154]</a><a href="#cite_note-Reducing_the_neglected_burden-155">[155]</a> While hepatitis A infections are self-limited events, they are associated with significant costs in the United States.<a href="#cite_note-Current_Childhood_Vaccination_Strategies-156">[156]</a> It has been estimated that <a href="/wiki/Direct_cost" class="mw-redirect" title="Direct cost">direct and indirect costs</a> are approximately $1817 and $2459 respectively per case, and that an average of 27 work days is lost per infected adult.<a href="#cite_note-Current_Childhood_Vaccination_Strategies-156">[156]</a> A 1997 report demonstrated that a single hospitalization related to hepatitis A cost an average of $6,900 and resulted in around $500 million in total annual healthcare costs.<a href="#cite_note-157">[157]</a> Cost effectiveness studies have found widespread vaccination of adults to not be feasible, but have stated that a combination hepatitis A and B vaccination of children and at risk groups (people from endemic areas, healthcare workers) may be.<a href="#cite_note-158">[158]</a> Hepatitis B accounts for a much larger percentage of health care spending in endemic regions like Asia.<a href="#cite_note-159">[159]</a><a href="#cite_note-Economics_of_treating_in_Asia-160">[160]</a> In 1997 it accounted for 3.2% of South Korea's total health care expenditures and resulted in $696 million in direct costs.<a href="#cite_note-Economics_of_treating_in_Asia-160">[160]</a> A large majority of that sum was spent on treating disease symptoms and complications.<a href="#cite_note-161">[161]</a> Chronic hepatitis B infections are not as endemic in the United States, but accounted for $357 million in hospitalization costs in the year 1990.<a href="#cite_note-Udompap,_Kim_&_Kim-154">[154]</a> That number grew to $1.5 billion in 2003, but remained stable as of 2006, which may be attributable to the introduction of effective drug therapies and vaccination campaigns.<a href="#cite_note-Udompap,_Kim_&_Kim-154">[154]</a><a href="#cite_note-Reducing_the_neglected_burden-155">[155]</a> People infected with chronic hepatitis C tend to be frequent users of the health care system globally.<a href="#cite_note-Younossi,_Kanwal,_Saab,_et_al-162">[162]</a> It has been estimated that a person infected with hepatitis C in the United States will result in a monthly cost of $691.<a href="#cite_note-Younossi,_Kanwal,_Saab,_et_al-162">[162]</a> That number nearly doubles to $1,227 for people with compensated (stable) cirrhosis, while the monthly cost of people with decompensated (worsening) cirrhosis is almost five times as large at $3,682.<a href="#cite_note-Younossi,_Kanwal,_Saab,_et_al-162">[162]</a> The wide-ranging effects of hepatitis make it difficult to estimate indirect costs, but studies have speculated that the total cost is $6.5 billion annually in the United States.<a href="#cite_note-Udompap,_Kim_&_Kim-154">[154]</a> In Canada, 56% of HCV related costs are attributable to cirrhosis and total expenditures related to the virus are expected to peak at CAD$396 million in the year 2032.<a href="#cite_note-163">[163]</a> <div class="mw-heading mw-heading3"><h3 id="2003_Monaca_outbreak">2003 Monaca outbreak</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=75" title="Edit section: 2003 Monaca outbreak">edit</a>]</div> The largest outbreak of hepatitis A virus in United States history occurred among people who ate at a now-defunct Mexican food restaurant located in Monaca, Pennsylvania in late 2003.<a href="#cite_note-green_onions-164">[164]</a> Over 550 people who visited the restaurant between September and October 2003 were infected with the virus, three of whom died as a direct result.<a href="#cite_note-green_onions-164">[164]</a> The outbreak was brought to the attention of health officials when local <a href="/wiki/Emergency_medicine" title="Emergency medicine">emergency medicine</a> physicians noticed a significant increase in cases of hepatitis A in the county.<a href="#cite_note-165">[165]</a> After conducting its investigation, the <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a> attributed the source of the outbreak to the use of contaminated raw <a href="/wiki/Scallion" title="Scallion">green onion</a>. The restaurant was purchasing its green onion stock from farms in Mexico at the time.<a href="#cite_note-green_onions-164">[164]</a> It is believed that the green onions may have been contaminated through the use of contaminated water for crop irrigation, rinsing, or icing or by handling of the vegetables by infected people.<a href="#cite_note-green_onions-164">[164]</a> Green onion had caused similar outbreaks of hepatitis A in the southern United States prior to this, but not to the same magnitude.<a href="#cite_note-green_onions-164">[164]</a> The CDC believes that the restaurant's use of a large communal bucket for chopped raw green onion allowed non-contaminated plants to be mixed with contaminated ones, increasing the number of vectors of infection and amplifying the outbreak.<a href="#cite_note-green_onions-164">[164]</a> The restaurant was closed once it was discovered to be the source, and over 9,000 people were given hepatitis A <a href="/wiki/Antibody" title="Antibody">immune globulin</a> because they had either eaten at the restaurant or had been in close contact with someone who had.<a href="#cite_note-green_onions-164">[164]</a> <div class="mw-heading mw-heading2"><h2 id="Special_populations">Special populations</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=76" title="Edit section: Special populations">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="HIV_co-infection">HIV co-infection</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=77" title="Edit section: HIV co-infection">edit</a>]</div> Persons infected with HIV have a particularly high burden of <a href="/wiki/Hepatitis_C_and_HIV_coinfection" title="Hepatitis C and HIV coinfection">HIV-HCV co-infection</a>.<a href="#cite_note-HIV_co-infection-166">[166]</a><a href="#cite_note-Platt,_Easterbrook_et_al-167">[167]</a> In a recent study by the <a href="/wiki/World_Health_Organization" title="World Health Organization">WHO</a>, the likelihood of being infected with hepatitis C virus was six times greater in those who also had HIV.<a href="#cite_note-Platt,_Easterbrook_et_al-167">[167]</a> The prevalence of HIV-HCV co-infection worldwide was estimated to be 6.2% representing more than 2.2 million people.<a href="#cite_note-Platt,_Easterbrook_et_al-167">[167]</a> Intravenous drug use was an independent risk factor for HCV infection.<a href="#cite_note-Rosen_-_Clinical_Practice-132">[132]</a> In the WHO study, the prevalence of HIV-HCV co-infection was markedly higher at 82.4% in those who injected drugs compared to the general population (2.4%).<a href="#cite_note-Platt,_Easterbrook_et_al-167">[167]</a> In a study of HIV-HCV co-infection among HIV positive men who have sex with men (MSM), the overall prevalence of anti-hepatitis C antibodies was estimated to be 8.1% and increased to 40% among HIV positive MSM who also injected drugs.<a href="#cite_note-HIV_co-infection-166">[166]</a> <div class="mw-heading mw-heading3"><h3 id="Pregnancy">Pregnancy</h3>[<a href="/w/index.php?title=Hepatitis&action=edit&section=78" title="Edit section: Pregnancy">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_B_6">Hepatitis B</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=79" title="Edit section: Hepatitis B">edit</a>]</div> <a href="/wiki/Vertically_transmitted_infection" title="Vertically transmitted infection">Vertical transmission</a> is a significant contributor of new <a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">HBV</a> cases each year, with 35–50% of transmission from mother to neonate in endemic countries.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-mother-to-neonate-168">[168]</a> Vertical transmission occurs largely via a neonate's exposure to maternal blood and vaginal secretions during birth.<a href="#cite_note-mother-to-neonate-168">[168]</a> While the risk of progression to chronic infection is approximately 5% among adults who contract the virus, it is as high as 95% among neonates subject to vertical transmission.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-169">[169]</a> The risk of viral transmission is approximately 10–20% when maternal blood is positive for HBsAg, and up to 90% when also positive for <a href="/wiki/HBeAg" title="HBeAg">HBeAg</a>.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a> Given the high risk of perinatal transmission, the <a href="/wiki/Centre_for_Disease_Control" class="mw-redirect" title="Centre for Disease Control">CDC</a> recommends screening all pregnant women for HBV at their first prenatal visit.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-170">[170]</a> It is safe for non-immune pregnant women to receive the HBV vaccine.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-mother-to-neonate-168">[168]</a> Based on the limited available evidence, the <a href="/wiki/American_Association_for_the_Study_of_Liver_Diseases" title="American Association for the Study of Liver Diseases">American Association for the Study of Liver Diseases</a> (AASLD) recommends antiviral therapy in pregnant women whose viral load exceeds 200,000 IU/mL.<a href="#cite_note-AASLD_guidelines_for_chronic_B-171">[171]</a> A growing body of evidence shows that antiviral therapy initiated in the third trimester significantly reduces transmission to the neonate.<a href="#cite_note-mother-to-neonate-168">[168]</a><a href="#cite_note-AASLD_guidelines_for_chronic_B-171">[171]</a> A systematic review of the Antiretroviral Pregnancy Registry database found that there was no increased risk of congenital anomalies with <a href="/wiki/Tenofovir_disoproxil" title="Tenofovir disoproxil">Tenofovir</a>; for this reason, along with its potency and low risk of resistance, the AASLD recommends this drug.<a href="#cite_note-AASLD_guidelines_for_chronic_B-171">[171]</a><a href="#cite_note-172">[172]</a> A 2010 systematic review and meta-analysis found that <a href="/wiki/Lamivudine" title="Lamivudine">Lamivudine</a> initiated early in the third trimester also significantly reduced mother-to-child transmission of HBV, without any known adverse effects.<a href="#cite_note-173">[173]</a> The <a href="/wiki/American_Congress_of_Obstetricians_and_Gynecologists" class="mw-redirect" title="American Congress of Obstetricians and Gynecologists">ACOG</a> states that the evidence available does not suggest any particular mode of delivery (i.e. <a href="/wiki/Vaginal_delivery" title="Vaginal delivery">vaginal</a> vs. <a href="/wiki/Caesarean_section" title="Caesarean section">cesarean</a>) is better at reducing vertical transmission in mothers with HBV.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a> The <a href="/wiki/World_Health_Organization" title="World Health Organization">WHO</a> and CDC recommend that neonates born to mothers with HBV should receive hepatitis B immune globulin (<a href="/wiki/Hepatitis_B_immune_globulin" title="Hepatitis B immune globulin">HBIG</a>) as well as the <a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">HBV vaccine</a> within 12 hours of birth.<a href="#cite_note-CDC_recommendations_for_Hepatitis_B-85">[85]</a><a href="#cite_note-WHO_guidelines_for_chronic_Hepatitis_B-87">[87]</a> For infants who have received HBIG and the HBV vaccine, breastfeeding is safe.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-mother-to-neonate-168">[168]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_C_5">Hepatitis C</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=80" title="Edit section: Hepatitis C">edit</a>]</div> Estimates of the rate of <a href="/wiki/Hepatitis_C_virus" title="Hepatitis C virus">HCV</a> vertical transmission range from 2–8%; a 2014 systematic review and meta-analysis found the risk to be 5.8% in HCV-positive, HIV-negative women.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-Benova_-_vertical_transmission-174">[174]</a> The same study found the risk of vertical transmission to be 10.8% in HCV-positive, HIV-positive women.<a href="#cite_note-Benova_-_vertical_transmission-174">[174]</a> Other studies have found the risk of vertical transmission to be as high as 44% among HIV-positive women.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a> The risk of vertical transmission is higher when the virus is detectable in the mother's blood.<a href="#cite_note-Benova_-_vertical_transmission-174">[174]</a> Evidence does not indicate that mode of delivery (i.e. vaginal vs. cesarean) has an effect on vertical transmission.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a> For women who are HCV-positive and HIV-negative, breastfeeding is safe. CDC guidelines suggest avoiding it if a woman's nipples are cracked or bleeding to reduce the risk of transmission.<a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-CDC_-_HCV_prevention-90">[90]</a> <div class="mw-heading mw-heading4"><h4 id="Hepatitis_E_4">Hepatitis E</h4>[<a href="/w/index.php?title=Hepatitis&action=edit&section=81" title="Edit section: Hepatitis E">edit</a>]</div> Pregnant women who contract <a href="/wiki/Hepatitis_E_virus" class="mw-redirect" title="Hepatitis E virus">HEV</a> are at significant risk of developing fulminant hepatitis with maternal mortality rates as high as 20–30%, most commonly in the third trimester .<a href="#cite_note-Harrison's_Principles,_chapter_360_(Acute_Viral)-17">[17]</a><a href="#cite_note-ACOG_Practice_Bulletin-88">[88]</a><a href="#cite_note-mother-to-neonate-168">[168]</a> A 2016 systematic review and meta-analysis of 47 studies that included 3968 people found maternal <a href="/wiki/Case_fatality_rate" title="Case fatality rate">case-fatality rates</a> (CFR) of 20.8% and fetal CFR of 34.2%; among women who developed fulminant hepatic failure, CFR was 61.2%.<a href="#cite_note-175">[175]</a> <div class="mw-heading mw-heading2"><h2 id="Vaccine">Vaccine</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=82" title="Edit section: Vaccine">edit</a>]</div> An essential defense against hepatitis infections, especially those caused by Hepatitis A and B, is the hepatitis vaccination. The Hepatitis B vaccination is quite effective and frequently used. The frequency of hepatitis-related liver illnesses and fatalities has been considerably decreased by the immunization campaigns.<a href="#cite_note-176">[176]</a> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=83" title="Edit section: See also">edit</a>]</div> <ul><li><a href="/wiki/Idiopathic_granulomatous_hepatitis" title="Idiopathic granulomatous hepatitis">Idiopathic granulomatous hepatitis</a></li> <li><a href="/wiki/World_Hepatitis_Day" title="World Hepatitis Day">World Hepatitis Day</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Hepatitis&action=edit&section=84" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-MedLine2016-1">^ <a href="#cite_ref-MedLine2016_1-0">a</a> <a href="#cite_ref-MedLine2016_1-1">b</a> <a href="#cite_ref-MedLine2016_1-2">c</a> <a href="#cite_ref-MedLine2016_1-3">d</a> <a href="#cite_ref-MedLine2016_1-4">e</a> <a href="#cite_ref-MedLine2016_1-5">f</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://medlineplus.gov/hepatitis.html">"Hepatitis"</a>. 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href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-31">af</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-32">ag</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-33">ah</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-34">ai</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-35">aj</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-36">ak</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-37">al</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-38">am</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-39">an</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-40">ao</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-41">ap</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-42">aq</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-43">ar</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-44">as</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-45">at</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-46">au</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-47">av</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-48">aw</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-49">ax</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-50">ay</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-51">az</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-52">ba</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-53">bb</a> <a href="#cite_ref-Harrison's_Principles,_chapter_360_(Acute_Viral)_17-54">bc</a> <a 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dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-label="Navbox32" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q131742" class="extiw" title="d:Q131742">D</a></div><div class="hlist" style="text-align:left;"><ul><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/K75.9">K75.9</a></li><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=573.3">573.3</a></li><li><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D006505">D006505</a></li><li><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb20061.htm">20061</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/medlineplus/ency/article/001154.htm">001154</a></li></ul></div></div></td></tr></tbody></table></div> <ul><li><a rel="nofollow" class="external text" href="https://www.cdc.gov/ncidod/diseases/hepatitis/">Viral Hepatitis at the Centers for Disease Control</a></li> <li><a rel="nofollow" class="external text" href="https://www.who.int/topics/hepatitis/en/">WHO fact sheet of hepatitis</a></li></ul> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Diseases_of_the_human_digestive_system290" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Digestive_system_diseases" title="Template:Digestive system diseases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Digestive_system_diseases" title="Template talk:Digestive system diseases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Digestive_system_diseases" title="Special:EditPage/Template:Digestive system diseases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Diseases_of_the_human_digestive_system290" style="font-size:114%;margin:0 4em">Diseases of the <a href="/wiki/Human_digestive_system" title="Human digestive system">human digestive system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gastrointestinal_tract#Upper_gastrointestinal_tract" title="Gastrointestinal tract">Upper GI tract</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Esophageal_disease" title="Esophageal disease">Esophagus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Esophagitis" title="Esophagitis">Esophagitis</a> <ul><li><a href="/wiki/Esophageal_candidiasis" title="Esophageal candidiasis">Candidal</a></li> <li><a href="/wiki/Eosinophilic_esophagitis" title="Eosinophilic esophagitis">Eosinophilic</a></li> <li><a href="/wiki/Herpetiform_esophagitis" class="mw-redirect" title="Herpetiform esophagitis">Herpetiform</a></li></ul></li> <li>Rupture <ul><li><a href="/wiki/Boerhaave_syndrome" class="mw-redirect" title="Boerhaave syndrome">Boerhaave syndrome</a></li> <li><a href="/wiki/Mallory%E2%80%93Weiss_syndrome" title="Mallory–Weiss syndrome">Mallory–Weiss syndrome</a></li></ul></li> <li><a href="/wiki/Zenker%27s_diverticulum" title="Zenker's diverticulum">Zenker's diverticulum</a></li> <li><a href="/wiki/Barrett%27s_esophagus" title="Barrett's esophagus">Barrett's esophagus</a></li> <li><a href="/wiki/Esophageal_motility_disorder" title="Esophageal motility disorder">Esophageal motility disorder</a> <ul><li><a href="/wiki/Nutcracker_esophagus" title="Nutcracker esophagus">Nutcracker esophagus</a></li> <li><a href="/wiki/Achalasia" class="mw-redirect" title="Achalasia">Achalasia</a></li> <li><a href="/wiki/Esophagogastric_junction_outflow_obstruction" title="Esophagogastric junction outflow obstruction">Esophagogastric junction outflow obstruction</a></li> <li><a href="/wiki/Diffuse_esophageal_spasm" title="Diffuse esophageal spasm">Diffuse esophageal spasm</a></li> <li><a href="/wiki/Gastroesophageal_reflux_disease" title="Gastroesophageal reflux disease">Gastroesophageal reflux disease</a> (GERD)</li></ul></li> <li><a href="/wiki/Laryngopharyngeal_reflux" title="Laryngopharyngeal reflux">Laryngopharyngeal reflux</a> (LPR)</li> <li><a href="/wiki/Esophageal_stricture" title="Esophageal stricture">Esophageal stricture</a></li> <li><a href="/wiki/Esophageal_inlet_patch" title="Esophageal inlet patch">Inlet patch</a></li> <li><a href="/wiki/Megaesophagus" title="Megaesophagus">Megaesophagus</a></li> <li><a href="/wiki/Esophageal_intramural_pseudodiverticulosis" title="Esophageal intramural pseudodiverticulosis">Esophageal intramural pseudodiverticulosis</a></li> <li><a href="/wiki/Acute_esophageal_necrosis" title="Acute esophageal necrosis">Acute esophageal necrosis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Stomach_disease" title="Stomach disease">Stomach</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gastritis" title="Gastritis">Gastritis</a> <ul><li><a href="/wiki/Atrophic_gastritis" title="Atrophic gastritis">Atrophic</a></li> <li><a href="/wiki/M%C3%A9n%C3%A9trier%27s_disease" title="Ménétrier's disease">Ménétrier's disease</a></li> <li><a href="/wiki/Gastroenteritis" title="Gastroenteritis">Gastroenteritis</a></li></ul></li> <li><a href="/wiki/Peptic_ulcer" class="mw-redirect" title="Peptic ulcer">Peptic (gastric) ulcer</a> <ul><li><a href="/wiki/Cushing_ulcer" title="Cushing ulcer">Cushing ulcer</a></li> <li><a href="/wiki/Dieulafoy%27s_lesion" title="Dieulafoy's lesion">Dieulafoy's lesion</a></li></ul></li> <li><a href="/wiki/Dyspepsia" class="mw-redirect" title="Dyspepsia">Dyspepsia</a> <ul><li><a href="/wiki/Functional_dyspepsia" title="Functional dyspepsia">Functional dyspepsia</a></li></ul></li> <li><a href="/wiki/Pyloric_stenosis" title="Pyloric stenosis">Pyloric stenosis</a></li> <li><a href="/wiki/Achlorhydria" title="Achlorhydria">Achlorhydria</a></li> <li><a href="/wiki/Gastroparesis" title="Gastroparesis">Gastroparesis</a></li> <li><a href="/wiki/Gastroptosis" title="Gastroptosis">Gastroptosis</a></li> <li><a href="/wiki/Portal_hypertensive_gastropathy" title="Portal hypertensive gastropathy">Portal hypertensive gastropathy</a></li> <li><a href="/wiki/Gastric_antral_vascular_ectasia" title="Gastric antral vascular ectasia">Gastric antral vascular ectasia</a></li> <li><a href="/wiki/Gastric_dumping_syndrome" class="mw-redirect" title="Gastric dumping syndrome">Gastric dumping syndrome</a></li> <li><a href="/wiki/Gastric_volvulus" title="Gastric volvulus">Gastric volvulus</a></li> <li><a href="/wiki/Buried_bumper_syndrome" title="Buried bumper syndrome">Buried bumper syndrome</a></li> <li><a href="/wiki/Gastrinoma" title="Gastrinoma">Gastrinoma</a> <ul><li><a href="/wiki/Zollinger%E2%80%93Ellison_syndrome" title="Zollinger–Ellison syndrome">Zollinger–Ellison syndrome</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gastrointestinal_tract#Lower_gastrointestinal_tract" title="Gastrointestinal tract">Lower GI tract</a> <a href="/wiki/Enteropathy" title="Enteropathy">Enteropathy</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Small_intestine" title="Small intestine">Small intestine</a> (<a href="/wiki/Duodenum" title="Duodenum">Duodenum</a>/<a href="/wiki/Jejunum" title="Jejunum">Jejunum</a>/<a href="/wiki/Ileum" title="Ileum">Ileum</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enteritis" title="Enteritis">Enteritis</a> <ul><li><a href="/wiki/Duodenitis" title="Duodenitis">Duodenitis</a></li> <li><a href="/wiki/Jejunitis" title="Jejunitis">Jejunitis</a></li> <li><a href="/wiki/Ileitis" title="Ileitis">Ileitis</a></li></ul></li> <li><a href="/wiki/Peptic_ulcer" class="mw-redirect" title="Peptic ulcer">Peptic (duodenal) ulcer</a> <ul><li><a href="/wiki/Curling%27s_ulcer" title="Curling's ulcer">Curling's ulcer</a></li></ul></li> <li><a href="/wiki/Malabsorption" title="Malabsorption">Malabsorption</a>: <a href="/wiki/Coeliac_disease" title="Coeliac disease">Coeliac</a></li> <li><a href="/wiki/Tropical_sprue" title="Tropical sprue">Tropical sprue</a></li> <li><a href="/wiki/Blind_loop_syndrome" title="Blind loop syndrome">Blind loop syndrome</a></li> <li><a href="/wiki/Small_intestinal_bacterial_overgrowth" title="Small intestinal bacterial overgrowth">Small intestinal bacterial overgrowth</a></li> <li><a href="/wiki/Whipple%27s_disease" title="Whipple's disease">Whipple's</a></li> <li><a href="/wiki/Short_bowel_syndrome" title="Short bowel syndrome">Short bowel syndrome</a></li> <li><a href="/wiki/Steatorrhea" title="Steatorrhea">Steatorrhea</a></li> <li><a href="/wiki/Milroy_disease" class="mw-redirect" title="Milroy disease">Milroy disease</a></li> <li><a href="/wiki/Bile_acid_malabsorption" title="Bile acid malabsorption">Bile acid malabsorption</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Large_intestine" title="Large intestine">Large intestine</a> (<a href="/wiki/Vermiform_appendix" class="mw-redirect" title="Vermiform appendix">Appendix</a>/<a href="/wiki/Colon_(anatomy)" class="mw-redirect" title="Colon (anatomy)">Colon</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Appendicitis" title="Appendicitis">Appendicitis</a></li> <li><a href="/wiki/Colitis" title="Colitis">Colitis</a> <ul><li><a href="/wiki/Pseudomembranous_colitis" class="mw-redirect" title="Pseudomembranous colitis">Pseudomembranous</a></li> <li><a href="/wiki/Ulcerative_colitis" title="Ulcerative colitis">Ulcerative</a></li> <li><a href="/wiki/Ischemic_colitis" title="Ischemic colitis">Ischemic</a></li> <li><a href="/wiki/Microscopic_colitis" title="Microscopic colitis">Microscopic</a></li> <li><a href="/wiki/Collagenous_colitis" title="Collagenous colitis">Collagenous</a></li> <li><a href="/wiki/Lymphocytic_colitis" title="Lymphocytic colitis">Lymphocytic</a></li></ul></li> <li><a href="/wiki/Dysentery" title="Dysentery">Dysentery</a></li> <li><a href="/wiki/Functional_colonic_disease" class="mw-redirect" title="Functional colonic disease">Functional colonic disease</a> <ul><li><a href="/wiki/Irritable_bowel_syndrome" title="Irritable bowel syndrome">IBS</a></li> <li><a href="/wiki/Intestinal_pseudoobstruction" class="mw-redirect" title="Intestinal pseudoobstruction">Intestinal pseudoobstruction</a> / <a href="/wiki/Ogilvie_syndrome" title="Ogilvie syndrome">Ogilvie syndrome</a></li></ul></li> <li><a href="/wiki/Megacolon" title="Megacolon">Megacolon</a> / <a href="/wiki/Toxic_megacolon" title="Toxic megacolon">Toxic megacolon</a></li> <li><a href="/wiki/Diverticulitis" title="Diverticulitis">Diverticulitis</a>/<a href="/wiki/Diverticulosis" title="Diverticulosis">Diverticulosis</a>/<a href="/wiki/Segmental_colitis_associated_with_diverticulosis" title="Segmental colitis associated with diverticulosis">SCAD</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Large and/or small</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enterocolitis" title="Enterocolitis">Enterocolitis</a> <ul><li><a href="/wiki/Necrotizing_enterocolitis" title="Necrotizing enterocolitis">Necrotizing</a></li></ul></li> <li><a href="/wiki/Gastroenterocolitis" title="Gastroenterocolitis">Gastroenterocolitis</a></li> <li><a href="/wiki/Inflammatory_bowel_disease" title="Inflammatory bowel disease">IBD</a> <ul><li><a href="/wiki/Crohn%27s_disease" title="Crohn's disease">Crohn's disease</a></li></ul></li> <li><a href="/wiki/Vascular_disease" title="Vascular disease">Vascular</a>: <a href="/wiki/Abdominal_angina" title="Abdominal angina">Abdominal angina</a></li> <li><a href="/wiki/Mesenteric_ischemia" class="mw-redirect" title="Mesenteric ischemia">Mesenteric ischemia</a></li> <li><a href="/wiki/Angiodysplasia" title="Angiodysplasia">Angiodysplasia</a></li> <li><a href="/wiki/Bowel_obstruction" title="Bowel obstruction">Bowel obstruction</a>: <a href="/wiki/Ileus" title="Ileus">Ileus</a></li> <li><a href="/wiki/Intussusception_(medical_disorder)" title="Intussusception (medical disorder)">Intussusception</a></li> <li><a href="/wiki/Volvulus" title="Volvulus">Volvulus</a></li> <li><a href="/wiki/Fecal_impaction" title="Fecal impaction">Fecal impaction</a></li> <li><a href="/wiki/Constipation" title="Constipation">Constipation</a> <ul><li><a href="/wiki/Functional_constipation" title="Functional constipation">Functional</a></li></ul></li> <li><a href="/wiki/Diarrhea" title="Diarrhea">Diarrhea</a> <ul><li><a href="/wiki/Infectious_diarrhea" class="mw-redirect" title="Infectious diarrhea">Infectious</a></li></ul></li> <li><a href="/wiki/Adhesion_(medicine)" title="Adhesion (medicine)">Intestinal adhesions</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Rectum" title="Rectum">Rectum</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proctitis" title="Proctitis">Proctitis</a> <ul><li><a href="/wiki/Radiation_proctitis" title="Radiation proctitis">Radiation proctitis</a></li></ul></li> <li><a href="/wiki/Proctalgia_fugax" title="Proctalgia fugax">Proctalgia fugax</a></li> <li><a href="/wiki/Rectal_prolapse" title="Rectal prolapse">Rectal prolapse</a></li> <li><a href="/wiki/Anismus" title="Anismus">Anismus</a></li> <li><a href="/wiki/Solitary_rectal_ulcer_syndrome" title="Solitary rectal ulcer syndrome">Solitary rectal ulcer syndrome</a></li> <li><a href="/wiki/Rectal_stricture" title="Rectal stricture">Rectal stricture</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Anal_canal" title="Anal canal">Anal canal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anal_fissure" title="Anal fissure">Anal fissure</a>/<a href="/wiki/Anal_fistula" title="Anal fistula">Anal fistula</a></li> <li><a href="/wiki/Anal_abscess" class="mw-redirect" title="Anal abscess">Anal abscess</a></li> <li><a href="/wiki/Hemorrhoid" title="Hemorrhoid">Hemorrhoid</a></li> <li><a href="/wiki/Anal_dysplasia" title="Anal dysplasia">Anal dysplasia</a></li> <li><a href="/wiki/Pruritus_ani" title="Pruritus ani">Pruritus ani</a></li> <li><a href="/wiki/Anal_stricture" title="Anal stricture">Anal stricture</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gastrointestinal_bleeding" title="Gastrointestinal bleeding">GI bleeding</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Blood_in_stool" title="Blood in stool">Blood in stool</a></li> <li><a href="/wiki/Upper_gastrointestinal_bleeding" title="Upper gastrointestinal bleeding">Upper</a> <ul><li><a href="/wiki/Hematemesis" title="Hematemesis">Hematemesis</a></li> <li><a href="/wiki/Melena" title="Melena">Melena</a></li></ul></li> <li><a href="/wiki/Lower_gastrointestinal_bleeding" title="Lower gastrointestinal bleeding">Lower</a> <ul><li><a href="/wiki/Hematochezia" title="Hematochezia">Hematochezia</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Accessory_digestive_gland" class="mw-redirect" title="Accessory digestive gland">Accessory</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Liver_disease" title="Liver disease">Liver</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Hepatitis</a> <ul><li><a href="/wiki/Viral_hepatitis" title="Viral hepatitis">Viral hepatitis</a></li> <li><a href="/wiki/Autoimmune_hepatitis" title="Autoimmune hepatitis">Autoimmune hepatitis</a></li> <li><a href="/wiki/Alcoholic_hepatitis" title="Alcoholic hepatitis">Alcoholic hepatitis</a></li></ul></li> <li><a href="/wiki/Cirrhosis" title="Cirrhosis">Cirrhosis</a> <ul><li><a href="/wiki/Primary_biliary_cirrhosis" class="mw-redirect" title="Primary biliary cirrhosis">PBC</a></li></ul></li> <li><a href="/wiki/Fatty_liver" class="mw-redirect" title="Fatty liver">Fatty liver</a> <ul><li><a href="/wiki/Metabolic_dysfunction%E2%80%93associated_steatotic_liver_disease" title="Metabolic dysfunction–associated steatotic liver disease">MASLD</a></li></ul></li> <li><a href="/wiki/Vascular_disease" title="Vascular disease">Vascular</a> <ul><li><a href="/wiki/Budd%E2%80%93Chiari_syndrome" title="Budd–Chiari syndrome">Budd–Chiari syndrome</a></li> <li><a href="/wiki/Hepatic_veno-occlusive_disease" title="Hepatic veno-occlusive disease">Hepatic veno-occlusive disease</a></li> <li><a href="/wiki/Portal_hypertension" title="Portal hypertension">Portal hypertension</a></li> <li><a href="/wiki/Nutmeg_liver" class="mw-redirect" title="Nutmeg liver">Nutmeg liver</a></li></ul></li> <li><a href="/wiki/Alcoholic_liver_disease" title="Alcoholic liver disease">Alcoholic liver disease</a></li> <li><a href="/wiki/Liver_failure" title="Liver failure">Liver failure</a> <ul><li><a href="/wiki/Hepatic_encephalopathy" title="Hepatic encephalopathy">Hepatic encephalopathy</a></li> <li><a href="/wiki/Acute_liver_failure" title="Acute liver failure">Acute liver failure</a></li></ul></li> <li><a href="/wiki/Liver_abscess" title="Liver abscess">Liver abscess</a> <ul><li><a href="/wiki/Pyogenic_liver_abscess" title="Pyogenic liver abscess">Pyogenic</a></li> <li><a href="/wiki/Amoebic_liver_abscess" title="Amoebic liver abscess">Amoebic</a></li></ul></li> <li><a href="/wiki/Hepatorenal_syndrome" title="Hepatorenal syndrome">Hepatorenal syndrome</a></li> <li><a href="/wiki/Peliosis_hepatis" title="Peliosis hepatis">Peliosis hepatis</a></li> <li><a href="/wiki/Metabolic_disorder" title="Metabolic disorder">Metabolic disorders</a> <ul><li><a href="/wiki/Wilson%27s_disease" title="Wilson's disease">Wilson's disease</a></li> <li><a href="/wiki/Hemochromatosis" class="mw-redirect" title="Hemochromatosis">Hemochromatosis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gallbladder_disease" title="Gallbladder disease">Gallbladder</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholecystitis" title="Cholecystitis">Cholecystitis</a></li> <li><a href="/wiki/Gallstone" title="Gallstone">Gallstone / Cholelithiasis</a></li> <li><a href="/wiki/Cholesterolosis_of_gallbladder" title="Cholesterolosis of gallbladder">Cholesterolosis</a></li> <li><a href="/wiki/Adenomyomatosis" title="Adenomyomatosis">Adenomyomatosis</a></li> <li><a href="/wiki/Postcholecystectomy_syndrome" title="Postcholecystectomy syndrome">Postcholecystectomy syndrome</a></li> <li><a href="/wiki/Porcelain_gallbladder" title="Porcelain gallbladder">Porcelain gallbladder</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bile_duct" title="Bile duct">Bile duct</a>/ Other <a href="/wiki/Biliary_tree" class="mw-redirect" title="Biliary tree">biliary tree</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholangitis" class="mw-redirect" title="Cholangitis">Cholangitis</a> <ul><li><a href="/wiki/Primary_sclerosing_cholangitis" title="Primary sclerosing cholangitis">Primary sclerosing cholangitis</a></li> <li><a href="/wiki/Secondary_sclerosing_cholangitis" title="Secondary sclerosing cholangitis">Secondary sclerosing cholangitis</a></li> <li><a href="/wiki/Ascending_cholangitis" title="Ascending cholangitis">Ascending</a></li></ul></li> <li><a href="/wiki/Cholestasis" title="Cholestasis">Cholestasis</a>/<a href="/wiki/Mirizzi%27s_syndrome" title="Mirizzi's syndrome">Mirizzi's syndrome</a></li> <li><a href="/wiki/Biliary_fistula" title="Biliary fistula">Biliary fistula</a></li> <li><a href="/wiki/Haemobilia" title="Haemobilia">Haemobilia</a></li></ul> <ul><li><a href="/wiki/Common_bile_duct" title="Common bile duct">Common bile duct</a> <ul><li><a href="/wiki/Choledocholithiasis" class="mw-redirect" title="Choledocholithiasis">Choledocholithiasis</a></li> <li><a href="/wiki/Biliary_dyskinesia" title="Biliary dyskinesia">Biliary dyskinesia</a></li></ul></li> <li><a href="/wiki/Sphincter_of_Oddi_dysfunction" title="Sphincter of Oddi dysfunction">Sphincter of Oddi dysfunction</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pancreatic_disease" title="Pancreatic disease">Pancreatic</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pancreatitis" title="Pancreatitis">Pancreatitis</a> <ul><li><a href="/wiki/Acute_pancreatitis" title="Acute pancreatitis">Acute</a></li> <li><a href="/wiki/Chronic_pancreatitis" title="Chronic pancreatitis">Chronic</a></li> <li><a href="/wiki/Hereditary_pancreatitis" title="Hereditary pancreatitis">Hereditary</a></li> <li><a href="/wiki/Pancreatic_abscess" title="Pancreatic abscess">Pancreatic abscess</a></li></ul></li> <li><a href="/wiki/Pancreatic_pseudocyst" title="Pancreatic pseudocyst">Pancreatic pseudocyst</a></li> <li><a href="/wiki/Exocrine_pancreatic_insufficiency" title="Exocrine pancreatic insufficiency">Exocrine pancreatic insufficiency</a></li> <li><a href="/wiki/Pancreatic_fistula" title="Pancreatic fistula">Pancreatic fistula</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Hernia43" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hernia" title="Hernia">Hernia</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Diaphragmatic_hernia" title="Diaphragmatic hernia">Diaphragmatic</a> <ul><li><a href="/wiki/Congenital_diaphragmatic_hernia" title="Congenital diaphragmatic hernia">Congenital</a></li></ul></li> <li><a href="/wiki/Hiatus_hernia" class="mw-redirect" title="Hiatus hernia">Hiatus</a></li></ul> <ul><li><a href="/wiki/Inguinal_hernia" title="Inguinal hernia">Inguinal</a> <ul><li><a href="/wiki/Indirect_inguinal_hernia" class="mw-redirect" title="Indirect inguinal hernia">Indirect</a></li> <li><a href="/wiki/Direct_inguinal_hernia" class="mw-redirect" title="Direct inguinal hernia">Direct</a></li></ul></li> <li><a href="/wiki/Umbilical_hernia" title="Umbilical hernia">Umbilical</a></li> <li><a href="/wiki/Femoral_hernia" title="Femoral hernia">Femoral</a></li> <li><a href="/wiki/Obturator_hernia" title="Obturator hernia">Obturator</a></li> <li><a href="/wiki/Spigelian_hernia" title="Spigelian hernia">Spigelian</a></li></ul> <ul><li><a href="/wiki/Lumbar_hernia" class="mw-redirect" title="Lumbar hernia">Lumbar</a> <ul><li><a href="/wiki/Petit%27s_hernia" title="Petit's hernia">Petit's</a></li> <li><a href="/wiki/Grynfeltt%E2%80%93Lesshaft_hernia" title="Grynfeltt–Lesshaft hernia">Grynfeltt–Lesshaft</a></li></ul></li></ul> <ul><li>Undefined location <ul><li><a href="/wiki/Incisional_hernia" title="Incisional hernia">Incisional</a></li> <li><a href="/wiki/Internal_hernia" title="Internal hernia">Internal hernia</a></li> <li><a href="/wiki/Richter%27s_hernia" title="Richter's hernia">Richter's</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Peritoneal_disease" class="mw-redirect" title="Peritoneal disease">Peritoneal</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Peritonitis" title="Peritonitis">Peritonitis</a> <ul><li><a href="/wiki/Spontaneous_bacterial_peritonitis" title="Spontaneous bacterial peritonitis">Spontaneous bacterial peritonitis</a></li></ul></li> <li><a href="/wiki/Hemoperitoneum" title="Hemoperitoneum">Hemoperitoneum</a></li> <li><a href="/wiki/Pneumoperitoneum" title="Pneumoperitoneum">Pneumoperitoneum</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> 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