JMSACL (Journal of Mass Spectrometry & Advances in the Clinical Lab)

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Translating pre-clinical research to clinical patient care. The official journal of the non-profit, MSACL. | The Journal of Mass Spectrometry and Advances in the Clinical Lab (JMSACL, formerly known as Clinical Mass Spectrometry) is an open access journal that publishes peer-reviewed articles addressing mass spectrometry and other advances in Laboratory Medicine and Pathology with a focus on development of diagnostic and related applications, including data science, to improve patient outcomes and reduce healthcare costs. Translating Pre-Clinical Research to Clinical Patient Care Beyond communication of the application of technologies in the routine clinical diagnostic setting, by publishing critically validated analytical protocols, the journal also addresses the translation of experimental techniques and analytical research into patient care, and the use of these technologies in clinical research and routine patient management. 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Translating Pre-Clinical Research to Clinical Patient Care Beyond communication of the application of technologies in the routine clinical diagnostic setting, by publishing critically validated analytical protocols, the journal also addresses the translation of experimental techniques and analytical research into patient care, and the use of these technologies in clinical research and routine patient management. 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The official journal of the non-profit, MSACL. | The Journal of Mass Spectrometry and Advances in the Clinical Lab (JMSACL, formerly known as Clinical Mass Spectrometry) is an open access journal that publishes peer-reviewed articles addressing mass spectrometry and other advances in Laboratory Medicine and Pathology with a focus on development of diagnostic and related applications, including data science, to improve patient outcomes and reduce healthcare costs. Translating Pre-Clinical Research to Clinical Patient Care Beyond communication of the application of technologies in the routine clinical diagnostic setting, by publishing critically validated analytical protocols, the journal also addresses the translation of experimental techniques and analytical research into patient care, and the use of these technologies in clinical research and routine patient management. 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class="top-card-layout__headline break-words font-sans text-md leading-open text-color-text"> Book and Periodical Publishing </h2> <h3 class="top-card-layout__first-subline font-sans text-md leading-open text-color-text-low-emphasis"> Del Mar, CA <span class="before:middot"></span> 920 followers </h3> <h4 class="top-card-layout__second-subline font-sans text-sm leading-open text-color-text-low-emphasis mt-0.5"> <span class="line-clamp-2">Translating pre-clinical research to clinical patient care. 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class="core-section-container__title section-title"> About us </h2>  <div class="core-section-container__content break-words"> <p class="break-words whitespace-pre-wrap text-color-text" data-test-id="about-us__description"> The Journal of Mass Spectrometry and Advances in the Clinical Lab (JMSACL, formerly known as Clinical Mass Spectrometry) is an open access journal that publishes peer-reviewed articles addressing mass spectrometry and other advances in Laboratory Medicine and Pathology with a focus on development of diagnostic and related applications, including data science, to improve patient outcomes and reduce healthcare costs. Translating Pre-Clinical Research to Clinical Patient Care Beyond communication of the application of technologies in the routine clinical diagnostic setting, by publishing critically validated analytical protocols, the journal also addresses the translation of experimental techniques and analytical research into patient care, and the use of these technologies in clinical research and routine patient management. The scope of the journal is not restricted to any particular technology, but covers the entire range of technologies and advancements that are expected to impact the clinical lab. The journal encourages submissions having a clear path to patient care, including basic and translational research, and animal studies. </p> <dl class="mt-6"> <div class="mb-2 flex papabear:mr-3 mamabear:mr-3 babybear:flex-wrap" data-test-id="about-us__website"> <dt class="font-sans text-md font-bold text-color-text break-words w-40 papabear:flex-shrink-0 papabear:mr-3 mamabear:flex-shrink-0 mamabear:mr-3 babybear:mb-1"> Website </dt> <dd class="font-sans text-md text-color-text break-words overflow-hidden"> <a class="link-no-visited-state hover:no-underline" data-tracking-control-name="about_website" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fwww%2Ejmsacl%2Eorg&urlhash=qEKe&trk=about_website" target="_blank" rel="noopener" data-tracking-will-navigate aria-describedby="websiteLinkDescription"> https://www.jmsacl.org <icon class="align-middle" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/49229g4q0jsla5l1xojq1wob9" aria-hidden="true"></icon> </a> <p class="hidden" id="websiteLinkDescription">External link for JMSACL (Journal of Mass Spectrometry & Advances in the Clinical Lab)</p> </dd> </div> <div class="mb-2 flex papabear:mr-3 mamabear:mr-3 babybear:flex-wrap" data-test-id="about-us__industry"> <dt class="font-sans text-md font-bold text-color-text break-words w-40 papabear:flex-shrink-0 papabear:mr-3 mamabear:flex-shrink-0 mamabear:mr-3 babybear:mb-1"> Industry </dt> <dd class="font-sans text-md text-color-text break-words overflow-hidden"> Book and Periodical Publishing </dd> </div> <div class="mb-2 flex papabear:mr-3 mamabear:mr-3 babybear:flex-wrap" data-test-id="about-us__size"> <dt class="font-sans text-md font-bold text-color-text break-words w-40 papabear:flex-shrink-0 papabear:mr-3 mamabear:flex-shrink-0 mamabear:mr-3 babybear:mb-1"> Company size </dt> <dd class="font-sans text-md text-color-text break-words overflow-hidden"> 2-10 employees </dd> </div> <div class="mb-2 flex papabear:mr-3 mamabear:mr-3 babybear:flex-wrap" data-test-id="about-us__headquarters"> <dt class="font-sans text-md font-bold text-color-text break-words w-40 papabear:flex-shrink-0 papabear:mr-3 mamabear:flex-shrink-0 mamabear:mr-3 babybear:mb-1"> Headquarters </dt> <dd class="font-sans text-md text-color-text break-words overflow-hidden"> Del Mar, CA </dd> </div> <div class="mb-2 flex papabear:mr-3 mamabear:mr-3 babybear:flex-wrap" data-test-id="about-us__organizationType"> <dt class="font-sans text-md font-bold text-color-text break-words w-40 papabear:flex-shrink-0 papabear:mr-3 mamabear:flex-shrink-0 mamabear:mr-3 babybear:mb-1"> Type </dt> <dd class="font-sans text-md text-color-text break-words overflow-hidden"> Nonprofit </dd> </div> <div class="mb-2 flex papabear:mr-3 mamabear:mr-3 babybear:flex-wrap" data-test-id="about-us__foundedOn"> <dt class="font-sans text-md font-bold text-color-text break-words w-40 papabear:flex-shrink-0 papabear:mr-3 mamabear:flex-shrink-0 mamabear:mr-3 babybear:mb-1"> Founded </dt> <dd class="font-sans text-md text-color-text break-words overflow-hidden"> 2016 </dd> </div>  </dl> </div> </section>  <section class="core-section-container core-section-container--with-border border-b-1 border-solid border-color-border-faint py-4 locations">  <h2 class="core-section-container__title section-title"> Locations </h2>  <div class="core-section-container__content break-words"> <ul class="show-more-less__list show-more-less__list--no-hidden-elems" data-impression-id="org-locations_show-more-less"> <li class="mb-3 papabear:w-50% papabear:odd:mr-2 papabear:odd:w-[calc(50%-16px)]"> <span class="tag-sm tag-enabled"> Primary </span> <div id="address-0">  <p> Del Mar, CA 92014, US </p> </div> <a class="link-no-visited-state hover:no-underline" data-tracking-control-name="org-locations_url" href="https://www.bing.com/maps?where=Del+Mar+92014+CA+US&trk=org-locations_url" target="_blank" rel="noopener" data-tracking-will-navigate aria-describedby="address-0"> Get directions 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href="https://www.linkedin.com/signup?session_redirect=https%3A%2F%2Fwww%2Elinkedin%2Ecom%2Fsearch%2Fresults%2Fpeople%2F%3FfacetCurrentCompany%3D%255B90933198%255D&trk=public_biz_employees-join" data-tracking-control-name="public_biz_employees-join" data-tracking-will-navigate> See all employees </a> </div> </section> <section class="core-section-container core-section-container--with-border border-b-1 border-solid border-color-border-faint py-4 updates" data-test-id="updates">  <h2 class="core-section-container__title section-title"> Updates </h2>  <div class="core-section-container__content break-words"> <ul class="updates__list"> <li class="mb-1"> <div data-id="entire-feed-card-link" class="relative"> <a class="main-feed-card__overlay-link absolute left-0 top-0 h-full w-full z-1 !border-0" href="https://www.linkedin.com/posts/jmsacl_single-cell-untargeted-lipidomics-using-liquid-activity-7296220797436641280-hUcb" data-id="main-feed-card__full-link" 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</div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  920 followers </p>  <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 2d  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list 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ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Report this post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">Source: (Journal of proteome research) Single cell lipidomics advances using liquid chromatography-ion mobility-mass spectrometry enable profiling of lipids in individual cells, revealing insights into cellular heterogeneity in disorders. The method identified 161 lipids in positive ion mode and 20 phospholipid species in negative ion mode from human cholangiocarcinoma cells, paving the way for single cell multiomics integration.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39950635%2F%3Ffc%3D20241202214358%26ff%3D20250214122705%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=yhZk&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Single Cell Untargeted Lipidomics Using Liquid Chromatography Ion Mobility-Mass Spectrometry" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" 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Analyzed 42 patients, revealing five key metabolites correlated with tacrolimus. Developed predictive model with good accuracy, suggesting potential for personalized tacrolimus therapy monitoring.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39949902%2F%3Ffc%3D20241202214358%26ff%3D20250214061742%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=JCoV&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Identification of urinary metabolites correlated with tacrolimus levels through high-precision liquid chromatography-mass spectrometry and machine learning algorithms in kidney transplant patients" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/sync/v2/D4D27AQFRiPBP63t5dg/articleshare-shrink_800/articleshare-shrink_800/0/1739532412560?e=2147483647&v=beta&t=Hqw5DutcCx_y6tr8IJ-bxS9E85aXewyWYvbvewin_uM" data-ghost-classes="tw-feed-content-ghost-image" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/42byfw7gh464l64dlwodbbdez">  <section class="flex justify-between article-content__header py-1"> <header> <h2 class="tw-feed-content-title" dir="ltr" data-test-id="article-content__title"> Identification of urinary metabolites correlated with tacrolimus levels through high-precision liquid chromatography-mass spectrometry and machine learning algorithms in kidney transplant patients </h2> <h3 class="tw-feed-content-subtitle" data-test-id="article-content__subtitle"> pubmed.ncbi.nlm.nih.gov </h3> </header>  </section> </a>   <code id="i18n_reaction_singular" style="display: none"></code> <code id="i18n_reactions_plural" style="display: none"></code> <div class="flex items-center 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</div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  920 followers </p>  <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 3d  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list hidden container-raised absolute w-auto overflow-y-auto flex-col items-stretch z-1 bottom-auto top-[100%]" role="menu" tabindex="-1"> <li class="ellipsis-menu__item border-t-1 border-solid border-color-border-low-emphasis first-of-type:border-none flex"> <a href="/uas/login?fromSignIn=true&session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fjmsacl&trk=organization_guest_main-feed-card_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7296037851870179330" data-semaphore-tracking-prefix="organization_guest_main-feed-card_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore 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Biopsies revealed complex suggesting endothelial injury leading to MPGN. Literature review indicates poor prognosis; all similar cases required dialysis within 3 years. New disease entity awareness is needed.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39947166%2F%3Ffc%3D20241202214358%26ff%3D20250214002031%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=77NM&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Membranoproliferative glomerulonephritis with striated ultrastructural deposits with significantly elevated fibrinogen and fibronectin on mass spectrometry analysis: A case report and literature review" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/sync/v2/D5627AQHEbBwX5cjCMQ/articleshare-shrink_800/articleshare-shrink_800/0/1739510978369?e=2147483647&v=beta&t=Jy0jOBcyMr3PX5AAwZTgSstkPotd1TcvjqU-Ei3q4us" data-ghost-classes="tw-feed-content-ghost-image" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/42byfw7gh464l64dlwodbbdez">  <section class="flex justify-between article-content__header py-1"> <header> <h2 class="tw-feed-content-title" dir="ltr" data-test-id="article-content__title"> Membranoproliferative glomerulonephritis with striated ultrastructural deposits with significantly elevated fibrinogen and fibronectin on mass spectrometry analysis: A case report and literature review </h2> <h3 class="tw-feed-content-subtitle" data-test-id="article-content__subtitle"> pubmed.ncbi.nlm.nih.gov </h3> </header>  </section> </a>   <code id="i18n_reaction_singular" style="display: none"></code> <code id="i18n_reactions_plural" style="display: none"></code>  <div 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Spectrometry &amp; Advances in the Clinical Lab)" data-tracking-will-navigate> JMSACL (Journal of Mass Spectrometry & Advances in the Clinical Lab) </a>  </div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  920 followers </p>  <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 3d  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 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data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Report this post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">Source: (Critical reviews in analytical chemistry) ICP-MS shows great potential in cancer research for tumor marker detection, identifying cancer biomolecules, discovering biomarkers, and studying drug uptake and distribution at the single-cell level, aiding in diagnosis, treatment evaluation, and drug discovery.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39945584%2F%3Futm_source%3DOther%26utm_medium%3Drss%26utm_campaign%3Dpubmed-2%26utm_content%3D1H77a1bY629-rOIu4QEUTAX3QvI9QH85df_uFZqcXVZyePvgHY%26fc%3D20241202214358%26ff%3D20250213122429%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=_NdS&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="The Application of Inductively Coupled Plasma Mass Spectrometry in Cancer Research" class="lazy-load 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</div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  920 followers </p>  <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 3d  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list hidden container-raised absolute w-auto overflow-y-auto flex-col items-stretch z-1 bottom-auto top-[100%]" role="menu" tabindex="-1"> <li class="ellipsis-menu__item border-t-1 border-solid border-color-border-low-emphasis first-of-type:border-none flex"> <a href="/uas/login?fromSignIn=true&session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fjmsacl&trk=organization_guest_main-feed-card_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7295836068501721090" data-semaphore-tracking-prefix="organization_guest_main-feed-card_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore 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pneumoniae). 2229 mass spectra analyzed using algorithms; CatBoost outperforms others (AUROC 0.91, F1 score 0.78 for E. coli). Transfer learning was less effective. Findings suggest gradient-boosting techniques can enhance resistance prediction, with potential clinical applications for early diagnosis. Future work needed on data standardization and algorithm refinement to combat antimicrobial resistance.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39940908%2F%3Ffc%3D20241202214358%26ff%3D20250213105837%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=hrz-&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Integrating Machine Learning with MALDI-TOF Mass Spectrometry for Rapid and Accurate Antimicrobial Resistance Detection in Clinical Pathogens" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/sync/v2/D5627AQHyvWz0cCzYEA/articleshare-shrink_800/articleshare-shrink_800/0/1739462869665?e=2147483647&v=beta&t=PYv6X9s1p5BxCcUSynjTpecRop_uLGpCtO4iQnfPOM0" data-ghost-classes="tw-feed-content-ghost-image" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/42byfw7gh464l64dlwodbbdez">  <section class="flex justify-between article-content__header py-1"> <header> <h2 class="tw-feed-content-title" dir="ltr" data-test-id="article-content__title"> Integrating Machine Learning with MALDI-TOF Mass Spectrometry for Rapid and Accurate Antimicrobial Resistance Detection in Clinical Pathogens </h2> <h3 class="tw-feed-content-subtitle" data-test-id="article-content__subtitle"> pubmed.ncbi.nlm.nih.gov </h3> </header>  </section> </a>   <code id="i18n_reaction_singular" style="display: none"></code> <code id="i18n_reactions_plural" style="display: none"></code> <div class="flex items-center font-sans text-sm babybear:text-xs 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</div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  920 followers </p>  <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 3d  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list 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href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fwww%2Esciencedirect%2Ecom%2Fscience%2Farticle%2Fpii%2FS2667145X25000045&urlhash=rJ_-&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="MRM-based LC-MS method for accurate C-peptide quantitation" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/sync/v2/D5627AQGaMJe7kPYAjg/articleshare-shrink_800/articleshare-shrink_800/0/1739448662080?e=2147483647&v=beta&t=dx7TS-GBcEf3_0wkXSfqsCfpTxqMEsyb8jQQIj6z_C0" data-ghost-classes="tw-feed-content-ghost-image" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/42byfw7gh464l64dlwodbbdez">  <section class="flex justify-between article-content__header py-1"> <header> <h2 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Analyzes 31 patients, revealing higher free lenvatinib in those with hepatic dysfunction (CP class B). Free concentration reflects hepatic function decline more sensitively than total concentration, suggesting clinical utility in impaired liver function.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39938627%2F%3Ffc%3D20241202214358%26ff%3D20250213002656%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=soQ3&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Sensitive quantification of free lenvatinib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and the clinical significance of measuring free lenvatinib concentration" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" 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data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Report this post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">Source: (Biochimica et biophysica acta. General subjects) Lipids analyzed via Raman spectroscopy and mass spectrometry reveal mechanisms of imatinib resistance in chronic myeloid leukemia (CML) blast crisis. Resistance detection, essential for treatment adjustments, was achieved by differentiating resistant from sensitive cells. Mass spectrometry provided lipid profiles linking changes to phospholipase A2 modulation via p38MAPK, highlighting the role of lipid alterations in TKI resistance.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39938699%2F%3Ffc%3D20241202214358%26ff%3D20250213001902%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=TtPo&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Analysis of lipids by Raman spectroscopy and mass spectrometry provides a detection tool and mechanistic insight into imatinib resistance in CML-BC" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" 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enable sensitive in situ detection of protein lipoylation through laser desorption/ionization mass spectrometry (LDI-MS). A butyraldehyde probe labels lipoylated proteins, linked to gold nanoparticles via click chemistry. Mass tags release under laser irradiation indicate lipoylation presence. This method enhances signal amplification and reveals lipoylation distribution in tissues, aiding in understanding biological processes and disease diagnosis.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39935505%2F%3Ffc%3D20241202214358%26ff%3D20250212061720%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=NSOb&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Chemoselective and laser cleavable probes for in situ protein lipoylation detection by laser desorption/ionization mass spectrometry" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" 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</div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  920 followers </p>  <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 5d  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="organization_guest_main-feed-card_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list 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vectors. Microfilariae were sourced from wild boars. Results showed complete separation of stages, with acetoacetic acid and hydroxylamine as notable metabolites. Hydroxylamine may serve as a marker for detecting infective larvae in onchocerciasis vector surveys.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fpubmed%2Encbi%2Enlm%2Enih%2Egov%2F39933644%2F%3Ffc%3D20241202214358%26ff%3D20250212001614%26v%3D2%2E18%2E0%2Epost9%2Be462414&urlhash=XoHo&trk=organization_guest_main-feed-card_feed-article-content" target="_self" data-tracking-control-name="organization_guest_main-feed-card_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content" role="button"> <img alt="Metabolomic analysis of larval stages of Onchocerca japonica (Spirurida: Onchocercidae), raised in black fly (Diptera: Simuliidae) vectors, by gas chromatography-tandem mass spectrometry" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" 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