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class="layout-container mx-auto"><div class="flex flex-col md:flex-row items-start md:items-center gap-2 md:gap-8"><h1 class="sc-dUHDFv dLLBJn layout-title ">Pyxis Oncology's Cancer Drug Progress Stirs Analyst Concerns</h1></div></div></div><div class="main-content-container layout-container mx-auto"><div class="layout-flex flex flex-col w-full items-start relative"><div class="layout-main w-full overflow-hidden flex flex-grow flex-col justify-between"><div class="flex flex-col w-full items-start lg:flex-row"><div class="sc-cgpWsj WlvEv article-submitted flex flex-grow"><div class="article-submitted-content"><div><div class="article-author-wrap"><span>by </span><span class="author"><a class="author-name" data-action="Clicked Author Link" href="/author/vandana-singh">Vandana Singh</a>, Benzinga Editor</span><div class="sc-lgpMbK fQLLYS"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="20" height="20" fill="none"><rect width="20" height="20" 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style="height:40px" class="lazyload-placeholder"></div></div><div class="h-[40px] w-[128px]"></div></div></div><div class="key-points-wrapper"><div class="sc-cVuPSX dYfkGj key-points "><h6 class="key-points-header">Zinger Key Points</h6><ul><li class="">PYX-201 showed a 50% objective response rate in 2L and 3L HNSCC patients, including one complete response and two partial responses.</li><li class="">Analyst reduces PYX-201 success probability to 10%, forecasting a $2.80 stock price with limited catalysts until late 2025.</li></ul></div></div><figure class="sc-jDEWiW jFGXLf image-placement"><div class="article-image bg-gray-100"><span style="background:none;border:0;box-sizing:border-box;display:block;height:initial;margin:0;opacity:1;overflow:hidden;padding:0;width:initial;position:absolute;top:0;left:0;bottom:0;right:0"><div role="img" class="sc-ilxebA wqbbK"></div><img alt="" title="Pyxis Oncology's Cancer Drug Progress Stirs Analyst Concerns" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" style="border:none;bottom:0;box-sizing:border-box;display:block;height:0;left:0;margin:auto;max-height:100%;max-width:100%;min-height:100%;min-width:100%;padding:0;position:absolute;right:0;top:0;width:0;object-fit:cover"/><noscript><img alt="" title="Pyxis Oncology's Cancer Drug Progress Stirs Analyst Concerns" sizes="(max-width: 800px) 120px, (min-width: 800px) 400px" src="https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=3840" srcSet="https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=16 16w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=32 32w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=48 48w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=64 64w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=96 96w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=128 128w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=256 256w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=384 384w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=640 640w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=750 750w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=828 828w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=1080 1080w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=1200 1200w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=1920 1920w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=2048 2048w, https://cdn.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png?optimize=medium&dpr=2&auto=webp&width=3840 3840w" decoding="async" loading="lazy" style="border:none;bottom:0;box-sizing:border-box;display:block;height:0;left:0;margin:auto;max-height:100%;max-width:100%;min-height:100%;min-width:100%;padding:0;position:absolute;right:0;top:0;width:0;object-fit:cover"/></noscript></span></div></figure><div class="sc-fiqhMp hTMfOU article-content-body" id="node-42113042"><div style="height:2px"></div><div class="sc-kNHrWM kBGsYt article-content-body-only " id="article-body" itemProp="articleBody" itemscope="" itemType="https://schema.org/Article"><div><p>On Wednesday, <strong>Pyxis Oncology, Inc. </strong><span class="ticker" data-ticker="PYXS" data-exchange="NASDAQ" style="display: inline-block;">PYXS</span> released preliminary data from the ongoing Phase 1 clinical dose escalation study evaluating PYX-201 in <a target="_blank" href="https://www.benzinga.com/pressreleases/24/11/g42099028/pyxis-oncology-announces-favorable-preliminary-pyx-201-clinical-phase-1-part-1-data" rel="noreferrer noopener">multiple solid tumors</a>.</p> <p>Among evaluable Head and Neck Squamous Cell Carcinoma (HNSCC) patients treated at an identified dose range of PYX-201 from 3.6 – 5.4 mg/kg (n=6), a confirmed 50% objective response rate (ORR) was observed, including one confirmed complete response (CR) and two confirmed partial responses (PR).</p> <p>The company additionally announced a Clinical Trial Collaboration Agreement with <strong>Merck & Co Inc </strong><span class="ticker" data-ticker="MRK" data-exchange="NYSE" style="display: inline-block;">MRK</span> for a Pyxis Oncology-sponsored study of PYX-201 in combination with Merck’s Keytruda (pembrolizumab) in patients with 1L and 2L HNSCC, HR+/HER2- breast cancer, and triple-negative breast cancer (TNBC) and sarcoma.</p> <ul> <li>PYX-201 and Keytruda combination dose escalation and expansion study in 1L and 2L HNSCC with preliminary clinical data readout expected in the second half of 2025.</li> <li>PYX-201 monotherapy study in 2L and 3L HNSCC patients who are platinum and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the second half of 2025.</li> <li>PYX-201 monotherapy study in 2L and 3L HNSCC patients who are EGFR and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the first half of 2026.</li> </ul> <p>Exploratory PYX-201 Phase 1 monotherapy expansion cohorts are planned for ovarian cancer, NSCLC, HR+/HER2 breast cancer, TNBC, and sarcoma. Preliminary clinical data are expected in the second half of 2025.</p> <ul> <li>The company also expects to initiate the PYX-201 and Keytruda combination study in HR+/HER2 breast cancer, TNBC, and sarcoma, with preliminary clinical data expected in the second half of 2025 and the first half of 2026.</li> <li>Preclinical studies of PYX-201 combined with other agents in ovarian cancer and NSCLC will commence in 2025, followed by clinical studies with preliminary clinical data expected in 2026.</li> </ul> <p>PYX-201 demonstrated favorable preliminary tolerability profile data with low incidence of dose discontinuation, interruptions, or delays due to treatment-related adverse events.</p> <p>William Blair analysts note that PYX-201 shows limited effectiveness outside of head-and-neck cancer, with only 8.7% of patients (2 out of 23) responding to tolerable doses of 3.6 mg/kg, 4.4 mg/kg, and 5.4 mg/kg.</p> <p>“At this point, we are unsure whether the three unconfirmed responses could ultimately be confirmed,” the analysts writes.</p> <p>The analysts has reduced the probability of success for PYX-201 to 10% from 35%. The updated fair value stands at $250 million or roughly $4.25 per share, comprising $1.77 per share from PYX-201 and $2.48 per share of cash.</p> <p>With no major stock-moving events expected until the second half of 2025, the analysts estimate the stock will trade around $2.80 per share soon. William Blair says it includes $1.77 per share for PYX-201 and $1.07 for remaining cash by late 2025.</p> <p>William Blair downgrades <a target="_blank" href="https://www.benzinga.com/quote/PYXS/analyst-ratings" rel="noreferrer noopener">Pyxis to Market Perform</a>, saying, “Since we view the head-and-neck cancer results as difficult to differentiate, coupled with modest activity in other solid tumor histologies.”</p> <p><strong>Price Action:</strong> PYXS stock is down 42.15% to $2.21 during premarket trading on Thursday.</p> <p><strong>Read Next:</strong></p> <ul> <li><strong><a href="https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence" target="_blank" rel="noreferrer noopener">Qualcomm’s Shift From Handsets To AI And Automotive Wins Analysts’ Confidence</a></strong></li> </ul> <p><em>Image created using artificial intelligence via Midjourney.</em></p></div><a class="text-sm my-4" href="https://www.benzinga.com/apis?utm_source=benzinga.com&utm_campaign=article-bottom" rel="noreferrer" target="_blank">Market News and Data brought to you by Benzinga APIs</a><p class="copyright">© 2024 Benzinga.com. 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class="copyright-section text-center w-full whitespace-nowrap mt-2">© 2024 Benzinga | All Rights Reserved</div></div></div></div><script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"article":{"id":"673f41373f4e8b0001bafc62","nodeId":42113042,"userId":288925,"versionId":50386806,"type":"story","published":true,"createdAt":"2024-11-21T14:18:34Z","updatedAt":"2024-11-21T14:18:35Z","title":"Pyxis Oncology's Cancer Drug Progress Stirs Analyst Concerns","titleSeo":"Pyxis Oncology Reports Data From Lead Cancer Drug Program In Solid Tumors, Analyst Downgrades As Challenges Remain","body":"\u003cp\u003eOn Wednesday, \u003cstrong\u003ePyxis Oncology, Inc.\u0026nbsp;\u003c/strong\u003e\u003cspan class=\"ticker\"\n data-ticker=\"PYXS\"\n data-exchange=\"NASDAQ\"\n style=\"display: inline-block;\"\u003ePYXS\u003c/span\u003e released preliminary data from the ongoing Phase 1 clinical dose escalation study evaluating PYX-201 in \u003ca target=\"_blank\" href=\"https://www.benzinga.com/pressreleases/24/11/g42099028/pyxis-oncology-announces-favorable-preliminary-pyx-201-clinical-phase-1-part-1-data\" rel=\"noreferrer noopener\"\u003emultiple solid tumors\u003c/a\u003e.\u003c/p\u003e\n\n\n\n\u003cp\u003eAmong evaluable Head and Neck Squamous Cell Carcinoma (HNSCC) patients treated at an identified dose range of PYX-201 from 3.6 – 5.4 mg/kg (n=6), a confirmed 50% objective response rate (ORR) was observed, including one confirmed complete response (CR) and two confirmed partial responses (PR).\u003c/p\u003e\n\n\n\n\u003cp\u003eThe company additionally announced a Clinical Trial Collaboration Agreement with \u003cstrong\u003eMerck \u0026amp; Co Inc \u003c/strong\u003e\u003cspan class=\"ticker\"\n data-ticker=\"MRK\"\n data-exchange=\"NYSE\"\n style=\"display: inline-block;\"\u003eMRK\u003c/span\u003e for a Pyxis Oncology-sponsored study of PYX-201 in combination with Merck\u0026#8217;s Keytruda (pembrolizumab) in patients with 1L and 2L HNSCC, HR+/HER2- breast cancer, and triple-negative breast cancer (TNBC) and sarcoma.\u003c/p\u003e\n\n\n\n\u003cul\u003e\n\u003cli\u003ePYX-201 and Keytruda combination dose escalation and expansion study in 1L and 2L HNSCC with preliminary clinical data readout expected in the second half of 2025.\u003c/li\u003e\n\n\n\n\u003cli\u003ePYX-201 monotherapy study in 2L and 3L HNSCC patients who are platinum and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the second half of 2025.\u003c/li\u003e\n\n\n\n\u003cli\u003ePYX-201 monotherapy study in 2L and 3L HNSCC patients who are EGFR and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the first half of 2026.\u003c/li\u003e\n\u003c/ul\u003e\n\n\n\n\u003cp\u003eExploratory PYX-201 Phase 1 monotherapy expansion cohorts are planned for ovarian cancer, NSCLC, HR+/HER2 breast cancer, TNBC, and sarcoma. Preliminary clinical data are expected in the second half of 2025.\u003c/p\u003e\n\n\n\n\u003cul\u003e\n\u003cli\u003eThe company also expects to initiate the PYX-201 and Keytruda combination study in HR+/HER2 breast cancer, TNBC, and sarcoma, with preliminary clinical data expected in the second half of 2025 and the first half of 2026.\u003c/li\u003e\n\n\n\n\u003cli\u003ePreclinical studies of PYX-201 combined with other agents in ovarian cancer and NSCLC will commence in 2025, followed by clinical studies with preliminary clinical data expected in 2026.\u003c/li\u003e\n\u003c/ul\u003e\n\n\n\n\u003cp\u003ePYX-201 demonstrated favorable preliminary tolerability profile data with low incidence of dose discontinuation, interruptions, or delays due to treatment-related adverse events.\u003c/p\u003e\n\n\n\n\u003cp\u003eWilliam Blair analysts note that PYX-201 shows limited effectiveness outside of head-and-neck cancer, with only 8.7% of patients (2 out of 23) responding to tolerable doses of 3.6 mg/kg, 4.4 mg/kg, and 5.4 mg/kg.\u003c/p\u003e\n\n\n\n\u003cp\u003e\u0026#8220;At this point, we are unsure whether the three unconfirmed responses could ultimately be confirmed,\u0026#8221; the analysts writes.\u003c/p\u003e\n\n\n\n\u003cp\u003eThe analysts has reduced the probability of success for PYX-201 to 10% from 35%. The updated fair value stands at $250 million or roughly $4.25 per share, comprising $1.77 per share from PYX-201 and $2.48 per share of cash.\u003c/p\u003e\n\n\n\n\u003cp\u003eWith no major stock-moving events expected until the second half of 2025, the analysts estimate the stock will trade around $2.80 per share soon. William Blair says it includes $1.77 per share for PYX-201 and $1.07 for remaining cash by late 2025.\u003c/p\u003e\n\n\n\n\u003cp\u003eWilliam Blair downgrades \u003ca target=\"_blank\" href=\"https://www.benzinga.com/quote/PYXS/analyst-ratings\" rel=\"noreferrer noopener\"\u003ePyxis to Market Perform\u003c/a\u003e, saying, \u0026#8220;Since we view the head-and-neck cancer results as difficult to differentiate, coupled with modest activity in other solid tumor histologies.\u0026#8221;\u003c/p\u003e\n\n\n\n\u003cp\u003e\u003cstrong\u003ePrice Action:\u003c/strong\u003e PYXS stock is down 42.15% to $2.21 during premarket trading on Thursday.\u003c/p\u003e\n\n\n\n\u003cp\u003e\u003cstrong\u003eRead Next:\u003c/strong\u003e\u003c/p\u003e\n\n\n\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e\u003ca href=\"https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence\" target=\"_blank\" rel=\"noreferrer noopener\"\u003eQualcomm\u0026#8217;s Shift From Handsets To AI And Automotive Wins Analysts\u0026#8217; Confidence\u003c/a\u003e\u003c/strong\u003e\u003c/li\u003e\n\u003c/ul\u003e\n\n\n\n\u003cp\u003e\u003cem\u003eImage created using artificial intelligence via Midjourney.\u003c/em\u003e\u003c/p\u003e","name":"Vandana Singh","assets":[{"type":"image","title":"biotech lab ai2","alt":"biotech lab","source":"Midjourney","mime":"","primary":true,"attributes":{"fid":"900696","filename":"biotech-lab-ai2.png","filepath":"files/images/story/2024/11/21/biotech-lab-ai2.png","filesize":0,"image_attributes":{"resolution":{"height":0,"width":0,"dpi":0}}}}],"partnerUrl":"","teaserText":"Pyxis Oncology announces mixed Phase 1 PYX-201 data, collaboration with Merck, and analyst downgrade citing limited efficacy beyond head-and-neck cancer.","canonicalPath":"general/biotech/24/11/42113042/pyxis-oncologys-cancer-drug-progress-stirs-analyst-concerns","tags":[{"tid":868681,"vid":3,"name":"Expert Ideas"},{"tid":913345,"vid":3,"name":"Stories That Matter"},{"tid":768599,"vid":3,"name":"why it's moving"}],"tickers":[{"tid":820014,"vid":2,"name":"PYXS","primary":true},{"tid":15497,"vid":2,"name":"MRK","description":"Merck \u0026 Company"}],"channels":[{"tid":68,"vid":1,"name":"Analyst Color"},{"tid":19868,"vid":1,"name":"Biotech"},{"tid":57,"vid":1,"name":"News"},{"tid":70,"vid":1,"name":"Downgrades"},{"tid":140295,"vid":1,"name":"Health Care"},{"tid":138079,"vid":1,"name":"Top Stories"},{"tid":67,"vid":1,"name":"Analyst Ratings"},{"tid":24,"vid":1,"name":"Movers"},{"tid":22,"vid":1,"name":"Trading Ideas"},{"tid":18467,"vid":1,"name":"General"}],"quotes":[{"exchange":"NASDAQ","name":"Pyxis Oncology","price":1.98,"symbol":"PYXS","type":"STOCK","volume":905705},{"exchange":"NYSE","name":"Merck \u0026 Co","price":100.63,"symbol":"MRK","type":"STOCK","volume":2330659}],"keyItems":[{"value":"PYX-201 showed a 50% objective response rate in 2L and 3L HNSCC patients, including one complete response and two partial responses."},{"value":"Analyst reduces PYX-201 success probability to 10%, forecasting a $2.80 stock price with limited catalysts until late 2025."}],"isBzPost":true,"isBzProPost":true,"doNotDistribute":false,"sentiment":0,"meta":{"SectorV2":{"SIC":[{"IndustryCode":2834,"Industry":"Pharmaceutical Preparations","IndustryGroup":283,"MajorGroup":28,"Division":""}],"NAICS":[{"NationalIndustryCode":325412,"NationalIndustry":"Pharmaceutical Preparation Manufacturing ","IndustryCode":32541,"Industry":"Pharmaceutical and Medicine Manufacturing","IndustryGroupCode":3254,"IndustryGroup":"Pharmaceutical and Medicine Manufacturing","SubSectorCode":325,"SubSector":"Chemical Manufacturing","SectorCode":32,"Sector":"Manufacturing"}],"Morningstar":[{"IndustryCode":20620010,"Industry":"Drug Manufacturers—General","IndustryGroupCode":20620,"IndustryGroup":"Drug Manufacturers","SectorCode":206,"Sector":"Healthcare","SuperSectorCode":2,"SuperSector":"Defensive"},{"IndustryCode":20610010,"Industry":"Biotechnology","IndustryGroupCode":20610,"IndustryGroup":"Biotechnology","SectorCode":206,"Sector":"Healthcare","SuperSectorCode":2,"SuperSector":"Defensive"}]},"Partner":null,"PartnerTaxonomy":null,"SEC":null,"Author":null,"Authors":[{"uid":"0","name":""}],"Flags":{"ShowCopyrightNotice":true,"EvergreenContent":false,"ShowAdvertiserDisclosure":false,"ContributedContent":false,"AddGoogleStandoutMetaTag":false,"MediaSiteDNDOverride":false,"SendToYahooFinance":false,"SendToRobinhood":true,"SendToMSN":true,"GeneratedByAI":false},"Reach":{"Disclosure":{}},"Reference":null,"Ext":null,"wp_post_meta":{"post_id":658761,"post_path":"general/biotech/24/11/42113042/pyxis-oncologys-cancer-drug-progress-stirs-analyst-concerns","post_type":"post","campaign_strategy":"Default"}},"image":"https://www.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png","isHeadline":false,"shouldDisplayedInFrame":false,"blocks":[{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"On Wednesday, ","nodeType":3,"tag":"","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Pyxis Oncology, Inc. 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2025.","nodeType":1,"tag":"li","tagAttributes":{}},{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"\n\n\n\n","nodeType":3,"tag":"","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"PYX-201 monotherapy study in 2L and 3L HNSCC patients who are platinum and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the second half of 2025.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"PYX-201 monotherapy study in 2L and 3L HNSCC patients who are platinum and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the second half of 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and Keytruda combination dose escalation and expansion study in 1L and 2L HNSCC with preliminary clinical data readout expected in the second half of 2025.\u003c/li\u003e\n\n\n\n\u003cli\u003ePYX-201 monotherapy study in 2L and 3L HNSCC patients who are platinum and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the second half of 2025.\u003c/li\u003e\n\n\n\n\u003cli\u003ePYX-201 monotherapy study in 2L and 3L HNSCC patients who are EGFR and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the first half of 2026.\u003c/li\u003e\n","nodeType":1,"tag":"ul","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Exploratory PYX-201 Phase 1 monotherapy expansion cohorts are planned for ovarian cancer, NSCLC, HR+/HER2 breast cancer, TNBC, and sarcoma. Preliminary clinical data are expected in the second half of 2025.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Exploratory PYX-201 Phase 1 monotherapy expansion cohorts are planned for ovarian cancer, NSCLC, HR+/HER2 breast cancer, TNBC, and sarcoma. Preliminary clinical data are expected in the second half of 2025.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"\n","nodeType":3,"tag":"","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"The company also expects to initiate the PYX-201 and Keytruda combination study in HR+/HER2 breast cancer, TNBC, and sarcoma, with preliminary clinical data expected in the second half of 2025 and the first half of 2026.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"The company also expects to initiate the PYX-201 and Keytruda combination study in HR+/HER2 breast cancer, TNBC, and sarcoma, with preliminary clinical data expected in the second half of 2025 and the first half of 2026.","nodeType":1,"tag":"li","tagAttributes":{}},{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"\n\n\n\n","nodeType":3,"tag":"","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Preclinical studies of PYX-201 combined with other agents in ovarian cancer and NSCLC will commence in 2025, followed by clinical studies with preliminary clinical data expected in 2026.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Preclinical studies of PYX-201 combined with other agents in ovarian cancer and NSCLC will commence in 2025, followed by clinical studies with preliminary clinical data expected in 2026.","nodeType":1,"tag":"li","tagAttributes":{}},{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"\n","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"\n\u003cli\u003eThe company also expects to initiate the PYX-201 and Keytruda combination study in HR+/HER2 breast cancer, TNBC, and sarcoma, with preliminary clinical data expected in the second half of 2025 and the first half of 2026.\u003c/li\u003e\n\n\n\n\u003cli\u003ePreclinical studies of PYX-201 combined with other agents in ovarian cancer and NSCLC will commence in 2025, followed by clinical studies with preliminary clinical data expected in 2026.\u003c/li\u003e\n","nodeType":1,"tag":"ul","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"PYX-201 demonstrated favorable preliminary tolerability profile data with low incidence of dose discontinuation, interruptions, or delays due to treatment-related adverse events.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"PYX-201 demonstrated favorable preliminary tolerability profile data with low incidence of dose discontinuation, interruptions, or delays due to treatment-related adverse events.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"William Blair analysts note that PYX-201 shows limited effectiveness outside of head-and-neck cancer, with only 8.7% of patients (2 out of 23) responding to tolerable doses of 3.6 mg/kg, 4.4 mg/kg, and 5.4 mg/kg.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"William Blair analysts note that PYX-201 shows limited effectiveness outside of head-and-neck cancer, with only 8.7% of patients (2 out of 23) responding to tolerable doses of 3.6 mg/kg, 4.4 mg/kg, and 5.4 mg/kg.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"“At this point, we are unsure whether the three unconfirmed responses could ultimately be confirmed,” the analysts writes.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"“At this point, we are unsure whether the three unconfirmed responses could ultimately be confirmed,” the analysts writes.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"The analysts has reduced the probability of success for PYX-201 to 10% from 35%. The updated fair value stands at $250 million or roughly $4.25 per share, comprising $1.77 per share from PYX-201 and $2.48 per share of cash.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"The analysts has reduced the probability of success for PYX-201 to 10% from 35%. The updated fair value stands at $250 million or roughly $4.25 per share, comprising $1.77 per share from PYX-201 and $2.48 per share of cash.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"With no major stock-moving events expected until the second half of 2025, the analysts estimate the stock will trade around $2.80 per share soon. William Blair says it includes $1.77 per share for PYX-201 and $1.07 for remaining cash by late 2025.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"With no major stock-moving events expected until the second half of 2025, the analysts estimate the stock will trade around $2.80 per share soon. William Blair says it includes $1.77 per share for PYX-201 and $1.07 for remaining cash by late 2025.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"William Blair downgrades ","nodeType":3,"tag":"","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Pyxis to Market Perform","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Pyxis to Market Perform","nodeType":1,"tag":"a","tagAttributes":{"target":"_blank","href":"https://www.benzinga.com/quote/PYXS/analyst-ratings","rel":"noreferrer noopener"}},{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":", saying, “Since we view the head-and-neck cancer results as difficult to differentiate, coupled with modest activity in other solid tumor histologies.”","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"William Blair downgrades \u003ca target=\"_blank\" href=\"https://www.benzinga.com/quote/PYXS/analyst-ratings\" rel=\"noreferrer noopener\"\u003ePyxis to Market Perform\u003c/a\u003e, saying, “Since we view the head-and-neck cancer results as difficult to differentiate, coupled with modest activity in other solid tumor histologies.”","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Price Action:","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Price Action:","nodeType":1,"tag":"strong","tagAttributes":{}},{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":" PYXS stock is down 42.15% to $2.21 during premarket trading on Thursday.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"\u003cstrong\u003ePrice Action:\u003c/strong\u003e PYXS stock is down 42.15% to $2.21 during premarket trading on Thursday.","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Read Next:","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Read Next:","nodeType":1,"tag":"strong","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"\u003cstrong\u003eRead Next:\u003c/strong\u003e","nodeType":1,"tag":"p","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"\n","nodeType":3,"tag":"","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Qualcomm’s Shift From Handsets To AI And Automotive Wins Analysts’ Confidence","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Qualcomm’s Shift From Handsets To AI And Automotive Wins Analysts’ Confidence","nodeType":1,"tag":"a","tagAttributes":{"href":"https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence","target":"_blank","rel":"noreferrer noopener"}}],"extracted":[],"hasChild":true,"innerHTML":"\u003ca href=\"https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence\" target=\"_blank\" rel=\"noreferrer noopener\"\u003eQualcomm’s Shift From Handsets To AI And Automotive Wins Analysts’ Confidence\u003c/a\u003e","nodeType":1,"tag":"strong","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"\u003cstrong\u003e\u003ca href=\"https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence\" target=\"_blank\" rel=\"noreferrer noopener\"\u003eQualcomm’s Shift From Handsets To AI And Automotive Wins Analysts’ Confidence\u003c/a\u003e\u003c/strong\u003e","nodeType":1,"tag":"li","tagAttributes":{}},{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"\n","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"\n\u003cli\u003e\u003cstrong\u003e\u003ca href=\"https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence\" target=\"_blank\" rel=\"noreferrer noopener\"\u003eQualcomm’s Shift From Handsets To AI And Automotive Wins Analysts’ Confidence\u003c/a\u003e\u003c/strong\u003e\u003c/li\u003e\n","nodeType":1,"tag":"ul","tagAttributes":{}},{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[{"blockName":"core/html","childBlocks":[],"extracted":[],"hasChild":false,"innerHTML":"Image created using artificial intelligence via Midjourney.","nodeType":3,"tag":"","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"Image created using artificial intelligence via Midjourney.","nodeType":1,"tag":"em","tagAttributes":{}}],"extracted":[],"hasChild":true,"innerHTML":"\u003cem\u003eImage created using artificial intelligence via Midjourney.\u003c/em\u003e","nodeType":1,"tag":"p","tagAttributes":{}}],"parsedBody":["\u003cp\u003eOn Wednesday, \u003cstrong\u003ePyxis Oncology, Inc.\u0026nbsp;\u003c/strong\u003e\u003cspan class=\"ticker\"\n data-ticker=\"PYXS\"\n data-exchange=\"NASDAQ\"\n style=\"display: inline-block;\"\u003ePYXS\u003c/span\u003e released preliminary data from the ongoing Phase 1 clinical dose escalation study evaluating PYX-201 in \u003ca target=\"_blank\" href=\"https://www.benzinga.com/pressreleases/24/11/g42099028/pyxis-oncology-announces-favorable-preliminary-pyx-201-clinical-phase-1-part-1-data\" rel=\"noreferrer noopener\"\u003emultiple solid tumors\u003c/a\u003e.\u003c/p\u003e","\n\n\n\n","\u003cp\u003eAmong evaluable Head and Neck Squamous Cell Carcinoma (HNSCC) patients treated at an identified dose range of PYX-201 from 3.6 – 5.4 mg/kg (n=6), a confirmed 50% objective response rate (ORR) was observed, including one confirmed complete response (CR) and two confirmed partial responses (PR).\u003c/p\u003e","\n\n\n\n","\u003cp\u003eThe company additionally announced a Clinical Trial Collaboration Agreement with \u003cstrong\u003eMerck \u0026amp; Co Inc \u003c/strong\u003e\u003cspan class=\"ticker\"\n data-ticker=\"MRK\"\n data-exchange=\"NYSE\"\n style=\"display: inline-block;\"\u003eMRK\u003c/span\u003e for a Pyxis Oncology-sponsored study of PYX-201 in combination with Merck\u0026#8217;s Keytruda (pembrolizumab) in patients with 1L and 2L HNSCC, HR+/HER2- breast cancer, and triple-negative breast cancer (TNBC) and sarcoma.\u003c/p\u003e","\n\n\n\n","\u003cul\u003e\n\u003cli\u003ePYX-201 and Keytruda combination dose escalation and expansion study in 1L and 2L HNSCC with preliminary clinical data readout expected in the second half of 2025.\u003c/li\u003e\n\n\n\n\u003cli\u003ePYX-201 monotherapy study in 2L and 3L HNSCC patients who are platinum and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the second half of 2025.\u003c/li\u003e\n\n\n\n\u003cli\u003ePYX-201 monotherapy study in 2L and 3L HNSCC patients who are EGFR and PD-1 inhibitor experienced, with preliminary clinical data readout expected in the first half of 2026.\u003c/li\u003e\n\u003c/ul\u003e","\n\n\n\n","\u003cp\u003eExploratory PYX-201 Phase 1 monotherapy expansion cohorts are planned for ovarian cancer, NSCLC, HR+/HER2 breast cancer, TNBC, and sarcoma. Preliminary clinical data are expected in the second half of 2025.\u003c/p\u003e","\n\n\n\n","\u003cul\u003e\n\u003cli\u003eThe company also expects to initiate the PYX-201 and Keytruda combination study in HR+/HER2 breast cancer, TNBC, and sarcoma, with preliminary clinical data expected in the second half of 2025 and the first half of 2026.\u003c/li\u003e\n\n\n\n\u003cli\u003ePreclinical studies of PYX-201 combined with other agents in ovarian cancer and NSCLC will commence in 2025, followed by clinical studies with preliminary clinical data expected in 2026.\u003c/li\u003e\n\u003c/ul\u003e","\n\n\n\n","\u003cp\u003ePYX-201 demonstrated favorable preliminary tolerability profile data with low incidence of dose discontinuation, interruptions, or delays due to treatment-related adverse events.\u003c/p\u003e","\n\n\n\n","\u003cp\u003eWilliam Blair analysts note that PYX-201 shows limited effectiveness outside of head-and-neck cancer, with only 8.7% of patients (2 out of 23) responding to tolerable doses of 3.6 mg/kg, 4.4 mg/kg, and 5.4 mg/kg.\u003c/p\u003e","\n\n\n\n","\u003cp\u003e\u0026#8220;At this point, we are unsure whether the three unconfirmed responses could ultimately be confirmed,\u0026#8221; the analysts writes.\u003c/p\u003e","\n\n\n\n","\u003cp\u003eThe analysts has reduced the probability of success for PYX-201 to 10% from 35%. The updated fair value stands at $250 million or roughly $4.25 per share, comprising $1.77 per share from PYX-201 and $2.48 per share of cash.\u003c/p\u003e","\n\n\n\n","\u003cp\u003eWith no major stock-moving events expected until the second half of 2025, the analysts estimate the stock will trade around $2.80 per share soon. William Blair says it includes $1.77 per share for PYX-201 and $1.07 for remaining cash by late 2025.\u003c/p\u003e","\n\n\n\n","\u003cp\u003eWilliam Blair downgrades \u003ca target=\"_blank\" href=\"https://www.benzinga.com/quote/PYXS/analyst-ratings\" rel=\"noreferrer noopener\"\u003ePyxis to Market Perform\u003c/a\u003e, saying, \u0026#8220;Since we view the head-and-neck cancer results as difficult to differentiate, coupled with modest activity in other solid tumor histologies.\u0026#8221;\u003c/p\u003e","\n\n\n\n","\u003cp\u003e\u003cstrong\u003ePrice Action:\u003c/strong\u003e PYXS stock is down 42.15% to $2.21 during premarket trading on Thursday.\u003c/p\u003e","\n\n\n\n","\u003cp\u003e\u003cstrong\u003eRead Next:\u003c/strong\u003e\u003c/p\u003e","\n\n\n\n","\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e\u003ca href=\"https://www.benzinga.com/analyst-ratings/price-target/24/11/42098028/qualcomms-shift-from-handsets-to-ai-and-automotive-wins-analysts-confidence\" target=\"_blank\" rel=\"noreferrer noopener\"\u003eQualcomm\u0026#8217;s Shift From Handsets To AI And Automotive Wins Analysts\u0026#8217; Confidence\u003c/a\u003e\u003c/strong\u003e\u003c/li\u003e\n\u003c/ul\u003e","\n\n\n\n","\u003cp\u003e\u003cem\u003eImage created using artificial intelligence via Midjourney.\u003c/em\u003e\u003c/p\u003e"],"author":{"about":"Vandana Singh, MBA Finance is an Editor of the Benzinga Breaking News. Vandana has been covering the healthcare sector for over 10 years, including providing support services to renowned investment banks.","byLine":"Benzinga Editor","companyTitle":null,"companyUrl":null,"facebook":null,"firstname":"Vandana","lastname":"Singh","linkedin":null,"name":"Vandana Singh","picture":"files/profile_pictures/288925_profPic.jpeg","profileUrl":"/author/vandana-singh","twitter":null,"uid":288925},"primaryImage":{"alt":"Pyxis Oncology's Cancer Drug Progress Stirs Analyst Concerns","height":574,"url":"https://www.benzinga.com/files/images/story/2024/11/21/biotech-lab-ai2.png","width":1024},"terms":[{"tid":"68","vid":"1","name":"Analyst 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moving","parent_id":"0","type":"Entities","url_drupal":"taxonomy/term/768599","url_public":"topic/why-its-moving"}],"commentCount":1,"metaProps":{"author":"Vandana Singh","authorId":288925,"authorType":"Benzinga Editor","authorURL":"/author/vandana-singh","canonical":"https://www.benzinga.com/general/biotech/24/11/42113042/pyxis-oncologys-cancer-drug-progress-stirs-analyst-concerns","dateCreated":"2024-11-21T09:18:34.000-05:00","dateUpdated":"2024-11-21T09:18:35.000-05:00","description":"Pyxis Oncology announces mixed Phase 1 PYX-201 data, collaboration with Merck, and analyst downgrade citing limited efficacy beyond head-and-neck cancer.","dimensions":{"authorName":"Vandana Singh","channels":["Analyst Color","Biotech","News","Downgrades","Health Care","Top Stories","Analyst Ratings","Movers","Trading 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