CINXE.COM

Publications Archive - Adaptive Biotech

<!doctype html> <html lang="en-US"> <head> <meta charset="UTF-8"><script type="text/javascript">(window.NREUM||(NREUM={})).init={ajax:{deny_list:["bam.nr-data.net"]}};(window.NREUM||(NREUM={})).loader_config={licenseKey:"NRJS-06e8c0ddbe21bad7c96",applicationID:"189529644"};;/*! For license information please see nr-loader-rum-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>g,gD:()=>h,xN:()=>p});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const u="[data-nr-mask]",d=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(u):""===t||null===t?e.mask_selector=u:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function g(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function p(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,d());const r=(0,s.nY)(e);r&&(r.init=l[e])}function h(e,t){if(!e)throw new Error(f);var r=g(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,xv:()=>n});const n="1.274.0",i="PROD",o="CDN"},6154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>c,RI:()=>i,WN:()=>d,bv:()=>o,gm:()=>a,mw:()=>s,sb:()=>u});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),u=c&&"undefined"==typeof SharedWorker,d=((()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);Array.isArray(e)&&e.length>=2&&e[1]})(),Date.now()-(0,n.t)())},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),g(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return g(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),g(e,t)})))}function g(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=g(n),c=h(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var p=m()[s[e]];p&&p.push([f,e,r,a]);return a},get:v,listeners:h,context:g,buffer:function(e,t){const r=m();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!m()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function g(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=h(e).concat(t)}function h(e){return n[e]||[]}function v(t){return d[t]=d[t]||e(f,t)}function m(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,bz:()=>a});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},3434:(e,t,r)=>{"use strict";r.d(t,{YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log";n.K7.logging},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{G4:()=>i});var n=r(2614);r(860).K7.sessionReplay;const i={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"};n.g.ERROR,n.g.FULL,n.g.OFF},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7603:(e,t,r)=>{"use strict";r.d(t,{j:()=>P});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),g=r(384),p=r(6344);const h=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],v=["setErrorHandler","finished","addToTrace","addRelease"];var m=r(1863),b=r(2614),y=r(993);var w=r(2646),A=r(3434);function R(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,A.YM)(i),a=new w.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function E(){const e=(0,g.pV)();h.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const x={};function _(e,t,g=!1){t||(0,c.Ak)(e,"api");const h={};var w=s.ee.get(e),A=w.get("tracer");x[e]=b.g.OFF,w.on(p.G4.REPLAY_RUNNING,(t=>{x[e]=t}));var E="api-",_=E+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),j(E,n,!0,o||null===r?"session":void 0)(t,r)}function T(){}h.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,w),function(e,t,r={},i=y.p_.INFO){(0,a.p)(f.xV,["API/logging/".concat(i.toLowerCase(),"/called")],void 0,n.K7.metrics,e),(0,a.p)(y.ET,[(0,m.t)(),t,r,i],void 0,n.K7.logging,e)}(w,e,t,r)},h.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,w),R(w,e,t,{customAttributes:r,level:i})},v.forEach((e=>{h[e]=j(E,e,!0,"api")})),h.addPageAction=j(E,"addPageAction",!0,n.K7.genericEvents),h.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,j(E,"setPageViewName",!0)()},h.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},h.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},h.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},h.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,w),w.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},h[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,w),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,w)},h[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,w),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,w)},h.interaction=function(e){return(new T).get("object"==typeof e?e:{})};const S=T.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,w),g||(0,a.p)(_+"tracer",[(0,m.t)(),e,r],i,n.K7.spa,w),function(){if(A.emit((o?"":"no-")+"fn-start",[(0,m.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw A.emit("fn-err",[arguments,this,t],r),t}finally{A.emit("fn-end",[(0,m.t)()],r)}}}};function j(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,w),i&&(0,a.p)(e+t,[(0,m.t)(),...arguments],r?null:this,i,w),r?void 0:this}}function k(){r.e(296).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),w.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{S[e]=j(_,e,void 0,g?n.K7.softNav:n.K7.spa)})),h.setCurrentRouteName=g?j(_,"routeName",void 0,n.K7.softNav):j(E,"routeName",!0,n.K7.spa),h.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,w),(0,a.p)("err",[t,(0,m.t)(),!1,r,!!x[e]],void 0,n.K7.jserrors,w)},d.RI?(0,u.GG)((()=>k()),!0):k(),h}var N=r(9417),T=r(8122);const S={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},j={};var k=r(5284);const I=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let O=!1;function P(e,t={},r,n){let{init:a,info:c,loader_config:u,runtime:l={},exposed:f=!0}=t;l.loaderType=r;const p=(0,g.pV)();c||(a=p.init,c=p.info,u=p.loader_config),(0,N.xN)(e.agentIdentifier,a||{}),function(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");j[e]=(0,T.a)(t,S);const r=(0,g.nY)(e);r&&(r.loader_config=j[e])}(e.agentIdentifier,u||{}),c.jsAttributes??={},d.bv&&(c.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,c);const h=(0,N.D0)(e.agentIdentifier),v=[c.beacon,c.errorBeacon];O||(h.proxy.assets&&(I(h.proxy.assets),v.push(h.proxy.assets)),h.proxy.beacon&&v.push(h.proxy.beacon),E(),(0,g.US)("activatedFeatures",k.B),e.runSoftNavOverSpa&&=!0===h.soft_navigations.enabled&&h.feature_flags.includes("soft_nav")),l.denyList=[...h.ajax.deny_list||[],...h.ajax.block_internal?v:[]],l.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,l),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=_(e.agentIdentifier,n,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=f),O=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>"nr-rum-1.274.0.min.js",i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={296:"sha512-gkYkZDAwQ9PwaDXs2YM+rNIdRej1Ac1mupWobRJ8eahQcXz6/sunGZCKklrzi5kWxhOGRZr2tn0rEKuLTXzfAA=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var g=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(g.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=g.bind(null,s.onerror),s.onload=g.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={840:0,374:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(7603);var l=i(1687),f=i(4234),g=i(5289),p=i(6154),h=i(384);const v=e=>p.RI&&!0===(0,s.gD)(e,"privacy.cookies_enabled");function m(e){return!!(0,h.dV)().o.MO&&v(e)&&!0===(0,s.gD)(e,"session_trace.enabled")}var b=i(6389);class y extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,b.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if(v(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(296).then(i.bind(i,3861));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(296).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(296).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,g.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return m(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var w=i(6630);class A extends y{static featureName=w.T;constructor(e,t=!0){super(e,w.T,t),this.importAggregator(e)}}var R=i(9908),E=i(2843),x=i(3878),_=i(782),N=i(1863);class T extends y{static featureName=_.T;constructor(e,t=!0){super(e,_.T,t),p.RI&&((0,E.u)((()=>(0,R.p)("docHidden",[(0,N.t)()],void 0,_.T,this.ee)),!0),(0,x.sp)("pagehide",(()=>(0,R.p)("winPagehide",[(0,N.t)()],void 0,_.T,this.ee))),this.importAggregator(e))}}var S=i(3969);class j extends y{static featureName=S.TZ;constructor(e,t=!0){super(e,S.TZ,t),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),p.gm?(this.features={},(0,h.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(A),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,h.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[A,T,j],loaderType:"lite"})})()})();</script> <meta name="viewport" content="width=device-width, initial-scale=1"> <link rel="profile" href="https://gmpg.org/xfn/11"> <meta name='robots' content='noindex, follow' /> <!-- This site is optimized with the Yoast SEO Premium plugin v21.9 (Yoast SEO v23.7) - https://yoast.com/wordpress/plugins/seo/ --> <title>Publications Archive - Adaptive Biotech</title> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="website" /> <meta property="og:title" content="Publications Archive" /> <meta property="og:url" content="https://www.adaptivebiotech.com/publications/" /> <meta property="og:site_name" content="Adaptive Biotech" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@AdaptiveBiotech" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"CollectionPage","@id":"https://www.adaptivebiotech.com/publications/","url":"https://www.adaptivebiotech.com/publications/","name":"Publications Archive - Adaptive Biotech","isPartOf":{"@id":"https://www.adaptivebiotech.com/#website"},"breadcrumb":{"@id":"https://www.adaptivebiotech.com/publications/#breadcrumb"},"inLanguage":"en-US"},{"@type":"BreadcrumbList","@id":"https://www.adaptivebiotech.com/publications/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.adaptivebiotech.com/"},{"@type":"ListItem","position":2,"name":"Publications"}]},{"@type":"WebSite","@id":"https://www.adaptivebiotech.com/#website","url":"https://www.adaptivebiotech.com/","name":"Adaptive Biotech","description":"Powering the Age of Immune Medicine.","publisher":{"@id":"https://www.adaptivebiotech.com/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://www.adaptivebiotech.com/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https://www.adaptivebiotech.com/#organization","name":"Adaptive Biotechnologies","url":"https://www.adaptivebiotech.com/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https://www.adaptivebiotech.com/#/schema/logo/image/","url":"https://www.adaptivebiotech.com/wp-content/uploads/2020/12/adaptive_logo_blue_tm.svg","contentUrl":"https://www.adaptivebiotech.com/wp-content/uploads/2020/12/adaptive_logo_blue_tm.svg","width":150.414,"height":38.068,"caption":"Adaptive Biotechnologies"},"image":{"@id":"https://www.adaptivebiotech.com/#/schema/logo/image/"},"sameAs":["https://www.facebook.com/adaptivebiotech/","https://x.com/AdaptiveBiotech","https://www.instagram.com/adaptivebiotech/?hl=en","https://www.linkedin.com/company/adaptive-biotechnologies-corp-","https://www.youtube.com/channel/UCmTjXgdI6GAIkILAOgRk8hA"]}]}</script> <!-- / Yoast SEO Premium plugin. --> <link rel='dns-prefetch' href='//www.adaptivebiotech.com' /> <link rel="alternate" type="application/rss+xml" title="Adaptive Biotech &raquo; Feed" href="https://www.adaptivebiotech.com/feed/" /> <link rel="alternate" type="application/rss+xml" title="Adaptive Biotech &raquo; Comments Feed" href="https://www.adaptivebiotech.com/comments/feed/" /> <link rel="alternate" type="application/rss+xml" title="Adaptive Biotech &raquo; Publications Feed" href="https://www.adaptivebiotech.com/publications/?feed=rss2" /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/www.adaptivebiotech.com\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <style id='wp-block-library-inline-css' type='text/css'> :root{--wp-admin-theme-color:#007cba;--wp-admin-theme-color--rgb:0,124,186;--wp-admin-theme-color-darker-10:#006ba1;--wp-admin-theme-color-darker-10--rgb:0,107,161;--wp-admin-theme-color-darker-20:#005a87;--wp-admin-theme-color-darker-20--rgb:0,90,135;--wp-admin-border-width-focus:2px;--wp-block-synced-color:#7a00df;--wp-block-synced-color--rgb:122,0,223;--wp-bound-block-color:var(--wp-block-synced-color)}@media (min-resolution:192dpi){:root{--wp-admin-border-width-focus:1.5px}}.wp-element-button{cursor:pointer}:root{--wp--preset--font-size--normal:16px;--wp--preset--font-size--huge:42px}:root .has-very-light-gray-background-color{background-color:#eee}:root .has-very-dark-gray-background-color{background-color:#313131}:root .has-very-light-gray-color{color:#eee}:root .has-very-dark-gray-color{color:#313131}:root .has-vivid-green-cyan-to-vivid-cyan-blue-gradient-background{background:linear-gradient(135deg,#00d084,#0693e3)}:root .has-purple-crush-gradient-background{background:linear-gradient(135deg,#34e2e4,#4721fb 50%,#ab1dfe)}:root .has-hazy-dawn-gradient-background{background:linear-gradient(135deg,#faaca8,#dad0ec)}:root .has-subdued-olive-gradient-background{background:linear-gradient(135deg,#fafae1,#67a671)}:root .has-atomic-cream-gradient-background{background:linear-gradient(135deg,#fdd79a,#004a59)}:root .has-nightshade-gradient-background{background:linear-gradient(135deg,#330968,#31cdcf)}:root .has-midnight-gradient-background{background:linear-gradient(135deg,#020381,#2874fc)}.has-regular-font-size{font-size:1em}.has-larger-font-size{font-size:2.625em}.has-normal-font-size{font-size:var(--wp--preset--font-size--normal)}.has-huge-font-size{font-size:var(--wp--preset--font-size--huge)}.has-text-align-center{text-align:center}.has-text-align-left{text-align:left}.has-text-align-right{text-align:right}#end-resizable-editor-section{display:none}.aligncenter{clear:both}.items-justified-left{justify-content:flex-start}.items-justified-center{justify-content:center}.items-justified-right{justify-content:flex-end}.items-justified-space-between{justify-content:space-between}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#ddd;clip:auto!important;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}html :where(.has-border-color){border-style:solid}html :where([style*=border-top-color]){border-top-style:solid}html :where([style*=border-right-color]){border-right-style:solid}html :where([style*=border-bottom-color]){border-bottom-style:solid}html :where([style*=border-left-color]){border-left-style:solid}html :where([style*=border-width]){border-style:solid}html :where([style*=border-top-width]){border-top-style:solid}html :where([style*=border-right-width]){border-right-style:solid}html :where([style*=border-bottom-width]){border-bottom-style:solid}html :where([style*=border-left-width]){border-left-style:solid}html :where(img[class*=wp-image-]){height:auto;max-width:100%}:where(figure){margin:0 0 1em}html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:var(--wp-admin--admin-bar--height,0px)}@media screen and (max-width:600px){html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:0px}} </style> <link rel='stylesheet' id='search-filter-plugin-styles-css' href='https://www.adaptivebiotech.com/wp-content/plugins/search-filter-pro/public/assets/css/search-filter.min.css?ver=2.5.19' type='text/css' media='all' /> <link rel='stylesheet' id='adaptive-biotech-style-header-css' href='https://www.adaptivebiotech.com/wp-content/themes/adaptive-biotech/style.css?ver=1.1.0' type='text/css' media='all' /> <link rel='stylesheet' id='kanopi-pack-theme-css' href='https://www.adaptivebiotech.com/wp-content/themes/adaptive-biotech/assets/dist/css/theme.ece36f57cdd7499d6db2.css?ver=1.1.0' type='text/css' media='all' /> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script type="text/javascript" id="salesforce_nfpluginsettings-js-extra"> /* <![CDATA[ */ var salesforce_nfpluginsettings = {"clearLogRestUrl":"https:\/\/www.adaptivebiotech.com\/wp-json\/salesforce-crm\/debug-log\/delete-all","clearLogButtonId":"nfsalesforcecrm_clear_debug_logger","downloadLogRestUrl":"https:\/\/www.adaptivebiotech.com\/wp-json\/salesforce-crm\/debug-log\/get-all","downloadLogButtonId":"nfsalesforcecrm_download_debug_logger"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-content/plugins/ninja-forms-salesforce-crm/assets/js/nfpluginsettings.js?ver=3.3.3" id="salesforce_nfpluginsettings-js"></script> <script type="text/javascript" id="search-filter-plugin-build-js-extra"> /* <![CDATA[ */ var SF_LDATA = {"ajax_url":"https:\/\/www.adaptivebiotech.com\/wp-admin\/admin-ajax.php","home_url":"https:\/\/www.adaptivebiotech.com\/","extensions":[]}; /* ]]> */ </script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-content/plugins/search-filter-pro/public/assets/js/search-filter-build.min.js?ver=2.5.19" id="search-filter-plugin-build-js"></script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-content/plugins/search-filter-pro/public/assets/js/chosen.jquery.min.js?ver=2.5.19" id="search-filter-plugin-chosen-js"></script> <link rel="https://api.w.org/" href="https://www.adaptivebiotech.com/wp-json/" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://www.adaptivebiotech.com/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.6.2" /> <!-- Google Tag Manager --> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-WKQJBWJ');</script> <!-- End Google Tag Manager --> <link rel="icon" href="https://www.adaptivebiotech.com/wp-content/uploads/2020/12/cropped-favicon512-150x150.png" sizes="32x32" /> <link rel="icon" href="https://www.adaptivebiotech.com/wp-content/uploads/2020/12/cropped-favicon512-260x260.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://www.adaptivebiotech.com/wp-content/uploads/2020/12/cropped-favicon512-260x260.png" /> <meta name="msapplication-TileImage" content="https://www.adaptivebiotech.com/wp-content/uploads/2020/12/cropped-favicon512-300x300.png" /> <style type="text/css" id="wp-custom-css"> .card.card--alternating { width: 100%; overflow: hidden; } .sf-field-taxonomy-publication_categories label:before { display: none; } </style> </head> <body class="archive post-type-archive post-type-archive-publication wp-custom-logo hfeed no-sidebar"> <!-- Google Tag Manager (noscript) --> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-WKQJBWJ" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <!-- End Google Tag Manager (noscript) --> <div id="page" class="site"> <a class="skip-link screen-reader-text" href="#content">Skip to content</a> <section class="notification-bar" role="complementary"> <div class="notification-bar__content container container--wide"> <h2 id="notification-heading">ASCO and EHA 2024 MRD Highlights</h2> <a href="https://www.adaptivebiotech.com/wp-content/uploads/2024/08/Adaptive-Biopharma-ASCO-EHA-Digest-2024-1.pdf" aria-labelledby="notification-heading" role="button">Read More</a> </div> </section> <header id="adaptive-biotech-header-wrapper" class="site-header"> <div class="site-header__container container container--wide"> <div class="nav-utility"> <div class="menu-utility-menu-container"><ul id="header-utlity-menu" class="menu"><li id="menu-item-21011" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21011"><a href="http://investors.adaptivebiotech.com/">Investors</a></li> <li id="menu-item-21012" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21012"><a href="https://www.adaptivebiotech.com/career-listings/">Join Our Team</a></li> </ul></div> </div><!-- .nav-utlity --> <div class="site-nav"> <div class="site-branding js-site-branding"> <div class="site-branding__image"> <a href="https://www.adaptivebiotech.com"> <img src="https://www.adaptivebiotech.com/wp-content/uploads/2020/12/adaptive_logo_blue_tm.svg" class="attachment-full size-full" alt="Logo for Adaptive Biotechnologies" decoding="async" /> </a> </div> <button id="menu-toggle" class="menu-toggle" aria-controls="adaptive-biotech-main-navigation" aria-expanded="false"> <svg class="icon-menu-toggle" aria-hidden="true" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 100"> <g class="svg-menu-toggle"> <path class="line line-1" d="M5 13h90v14H5z"></path> <path class="line line-2" d="M5 43h90v14H5z"></path> <path class="line line-3" d="M5 73h90v14H5z"></path> </g> </svg> <span class="screen-reader-text">Toggle Main Menu</span> </button> </div><!-- .site-branding --> <nav id="adpt-nav-wrapper" class="main-navigation nav--main"> <ul id="adaptive-biotech-main-navigation" class="adaptive-menu" role="menubar"><li role="menuitem" class="js-menu-heading menu-heading column-count-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-9528"><button class="dropdown-toggle" aria-expanded="false" data-toggles="submenu_9528" aria-label="Toggle Immune Medicine"><span>Immune Medicine<span class="sub-nav-toggle"></span></span></button> <ul class="sub-menu" id="submenu_9528"> <li role="menuitem" class="submenu-heading menu-column-1 menu-item menu-item-type-custom menu-item-object-custom menu-item-21013"><span>About</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21014"><a href="https://www.adaptivebiotech.com/our-platform/"><span>Immune Medicine Platform</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21015"><a href="https://www.adaptivebiotech.com/the-adaptive-immune-system/"><span>The Adaptive Immune System</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21016"><a href="https://www.adaptivebiotech.com/tcr-antigen-map/"><span>TCR Antigen Map</span></a> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21018"><a href="/publications/?_sft_publication_categories=immune-medicine"><span>Publications</span></a> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21269"><span>Pharma Services</span></li> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27730"><a href="https://www.adaptivebiotech.com/research-development-applications/"><span>Research &#038; Development Applications</span></a> <li role="menuitem" class="column-end menu-item menu-item-type-post_type menu-item-object-page menu-item-27731"><a href="https://www.adaptivebiotech.com/adaptive-immunosequencing/"><span>Adaptive Immunosequencing</span></a></ul></li> <li role="menuitem" class="submenu-heading menu-column-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-21020"><span>Drug Discovery</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27779"><a href="https://www.adaptivebiotech.com/tcr-therapeutics/"><span>TCR Therapeutics</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27781"><a href="https://www.adaptivebiotech.com/antibody-therapeutics/"><span>Antibody Therapeutics</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27780"><a href="https://www.adaptivebiotech.com/target-discovery/"><span>Target Discovery</span></a> <li role="menuitem" class="column-end menu-item menu-item-type-post_type menu-item-object-page menu-item-27782"><a href="https://www.adaptivebiotech.com/drug-discovery-pipeline/"><span>Pipeline</span></a></ul></li> </ul> <li role="menuitem" class="js-menu-heading menu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-9529"><button class="dropdown-toggle" aria-expanded="false" data-toggles="submenu_9529" aria-label="Toggle MRD"><span>MRD<span class="sub-nav-toggle"></span></span></button> <ul class="sub-menu" id="submenu_9529"> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21026"><span>About</span></li> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21027"><a href="/pipeline/#diagnostics"><span>Clinical Portfolio &#038; Pipeline</span></a> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21028"><a href="/publications/?_sft_publication_categories=mrd"><span>Publications</span></a> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21029"><span>Clinical Diagnostics</span></li> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21030"><a target="_blank" href="https://www.clonoseq.com/"><span>clonoSEQ</span></a> </ul> <li role="menuitem" class="js-menu-heading menu-heading column-count-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-9530"><button class="dropdown-toggle" aria-expanded="false" data-toggles="submenu_9530" aria-label="Toggle News & Events"><span>News &#038; Events<span class="sub-nav-toggle"></span></span></button> <ul class="sub-menu" id="submenu_9530"> <li role="menuitem" class="submenu-heading menu-column-1 menu-item menu-item-type-custom menu-item-object-custom menu-item-21032"><span>Blog</span><ul class="menu-column"> <li role="menuitem" class="blog--link menu-item menu-item-type-post_type menu-item-object-post menu-item-29576"><a href="https://www.adaptivebiotech.com/2024/10/24/jims-journey-the-power-of-collaboration-in-blood-cancer-care/"><span>Jim’s Journey: The Power of Collaboration in Blood Cancer Care</span></a> <li role="menuitem" class="blog--link menu-item menu-item-type-post_type menu-item-object-post menu-item-29094"><a href="https://www.adaptivebiotech.com/2024/06/27/pride-month-at-adaptive-celebrating-progress-and-community/"><span>Pride Month at Adaptive: Celebrating Progress and Community</span></a> <li role="menuitem" class="blog--link menu-item menu-item-type-post_type menu-item-object-post menu-item-29013"><a href="https://www.adaptivebiotech.com/2024/06/07/decoding-public-t-cell-signatures-of-disease-with-tens-of-thousands-of-t-cell-receptor-repertoires/"><span>Decoding Public T-cell Signatures of Disease with Tens of Thousands of T-cell Receptor Repertoires</span></a> <li role="menuitem" class="btn btn--link column-end menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-21042"><a href="https://www.adaptivebiotech.com/blog/"><span>See all posts</span></a></ul></li> <li role="menuitem" class="submenu-heading menu-column-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-21031"><span>Media</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21034"><a target="_blank" href="https://investors.adaptivebiotech.com/news-events/news-releases"><span>Press Releases</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21035"><a href="https://www.adaptivebiotech.com/media-resources/"><span>Media Resources</span></a> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21033"><span>Events</span></li> <li role="menuitem" class="column-end menu-item menu-item-type-post_type menu-item-object-page menu-item-21043"><a href="https://www.adaptivebiotech.com/conferences-events/"><span>Conferences &#038; Events</span></a></ul></li> </ul> <li role="menuitem" class="js-menu-heading menu-heading column-count-2 menu-item menu-item-type-custom menu-item-object-custom current-menu-ancestor current-menu-parent menu-item-has-children menu-item-9531"><button class="dropdown-toggle" aria-expanded="false" data-toggles="submenu_9531" aria-label="Toggle Our Science"><span>Our Science<span class="sub-nav-toggle"></span></span></button> <ul class="sub-menu" id="submenu_9531"> <li role="menuitem" class="submenu-heading menu-column-1 menu-item menu-item-type-custom menu-item-object-custom menu-item-21046"><span>Publications</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom current-menu-item menu-item-21051"><a href="/publications/"><span>Research Publications</span></a> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21279"><span>Credentials</span></li> <li role="menuitem" class="column-end menu-item menu-item-type-post_type menu-item-object-page menu-item-21278"><a href="https://www.adaptivebiotech.com/licenses-and-accreditation/"><span>Licenses and Accreditation</span></a></ul></li> <li role="menuitem" class="submenu-heading menu-column-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-21045"><span>Medical</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21047"><a href="https://www.adaptivebiotech.com/medical-affairs/"><span>Medical Affairs</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21048"><a href="https://www.adaptivebiotech.com/medical-information/"><span>Medical Information</span></a> <li role="menuitem" class="column-end menu-item menu-item-type-post_type menu-item-object-page menu-item-21049"><a href="https://www.adaptivebiotech.com/congress-data-presentations/"><span>Data &#038; Congresses</span></a></ul></li> </ul> <li role="menuitem" class="js-menu-heading menu-heading column-count-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-9532"><button class="dropdown-toggle" aria-expanded="false" data-toggles="submenu_9532" aria-label="Toggle About Us"><span>About Us<span class="sub-nav-toggle"></span></span></button> <ul class="sub-menu" id="submenu_9532"> <li role="menuitem" class="submenu-heading menu-column-1 menu-item menu-item-type-custom menu-item-object-custom menu-item-21053"><span>About Us</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21056"><a href="https://www.adaptivebiotech.com/who-we-are/"><span>Who We Are</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21057"><a href="https://www.adaptivebiotech.com/our-story/"><span>Our Story</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21058"><a href="https://www.adaptivebiotech.com/timeline/"><span>Innovation Timeline</span></a> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21059"><a href="https://www.adaptivebiotech.com/adaptive-leadership/"><span>Leadership</span></a> <li role="menuitem" class="column-end menu-item menu-item-type-post_type menu-item-object-page menu-item-27868"><a href="https://www.adaptivebiotech.com/corporate-social-responsibility/"><span>Corporate Social Responsibility</span></a></ul></li> <li role="menuitem" class="submenu-heading menu-column-2 menu-item menu-item-type-custom menu-item-object-custom menu-item-21281"><span>Careers</span><ul class="menu-column"> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27783"><a href="https://www.adaptivebiotech.com/career-listings/"><span>Career Listings</span></a> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21055"><span>Connect</span></li> <li role="menuitem" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21062"><a href="https://www.adaptivebiotech.com/contact-us/"><span>Contact</span></a> <li role="menuitem" class="submenu-heading menu-item menu-item-type-custom menu-item-object-custom menu-item-21287"><span>Investors</span></li> <li role="menuitem" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-21060"><a target="_blank" href="https://investors.adaptivebiotech.com/"><span>Investor Relations</span></a> <li role="menuitem" class="column-end menu-item menu-item-type-custom menu-item-object-custom menu-item-21061"><a target="_blank" href="https://investors.adaptivebiotech.com/news-events/news-releases"><span>Newsroom</span></a></ul></li> </ul> </ul> </nav> </div><!-- .site-nav --> </div><!-- .container container--wide --> </header><!-- #adaptive-biotech-header-wrapper --> <div id="content"> <div id="primary" class="content-area"> <main id="main" class="site-main"> <header class="publication--heading" style="background-image:url(https://www.adaptivebiotech.com/wp-content/uploads/2023/11/adaptive-a-hero-waves-2.webp);"> <div class="publication--heading-opacity"></div> <div class="container publication--heading-content"> <h1 class="publication--heading-h1">Browse our 650+ Publications​</h1> <form data-sf-form-id='8920' data-is-rtl='0' data-maintain-state='' data-results-url='https://www.adaptivebiotech.com/publications/' data-ajax-form-url='https://www.adaptivebiotech.com/?sfid=8920&amp;sf_action=get_data&amp;sf_data=form' data-display-result-method='post_type_archive' data-use-history-api='1' data-template-loaded='0' data-lang-code='en' data-ajax='0' data-init-paged='1' data-auto-update='1' action='https://www.adaptivebiotech.com/publications/' method='post' class='searchandfilter' id='search-filter-form-8920' autocomplete='off' data-instance-count='1'><ul><li class="sf-field-search" data-sf-field-name="search" data-sf-field-type="search" data-sf-field-input-type=""> <label> <input placeholder="Search …" name="_sf_search[]" class="sf-input-text" type="text" value="" title=""></label> </li><li class="sf-field-taxonomy-publication_categories" data-sf-field-name="_sft_publication_categories" data-sf-field-type="taxonomy" data-sf-field-input-type="select"> <label> <select name="_sft_publication_categories[]" class="sf-input-select" title=""> <option class="sf-level-0 sf-item-0 sf-option-active" selected="selected" data-sf-count="0" data-sf-depth="0" value="">All</option> <option class="sf-level-0 sf-item-294" data-sf-count="893" data-sf-depth="0" value="immune-medicine">Immune Medicine</option> <option class="sf-level-0 sf-item-293" data-sf-count="108" data-sf-depth="0" value="mrd">MRD</option> </select></label> </li></ul></form> </div> </header> <div class="container vertical-padding--medium"> <h2 class="publication--heading-h2">Latest Publications</h2> <article id="post-29619" class="publication--item post-29619 publication type-publication status-publish hentry publication_categories-mrd publication_tags-blood"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://ashpublications.org/blood/article/doi/10.1182/blood.2024025563/518286/Zanubrutinib-Obinutuzumab-and-Venetoclax-for-First">Zanubrutinib, Obinutuzumab, and Venetoclax for First-Line Treatment of Mantle Cell Lymphoma with a TP53 Mutation</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Kumar A, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Blood </div> <!-- publication--tags --> <div class="publication--date"> October 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Anita Kumar, MD1, Jacob Soumerai, MD2, Jeremy S. Abramson, MD2, Jeffrey A. Barnes, MD2, PhD, Philip Caron, MD1, Shalini Chhabra, MD1, Maria Chabowska, BSc1, Ahmet Dogan, MD1, PhD1, Lorenzo Falchi, MD1, Clare Grieve, MPH1, Julie E. Haydu, MD PhD2, Patrick Connor Johnson, MD2, Ashlee Joseph BS1, Hailey E. Kelly2, Alyssa Labarre1, Jennifer Kimberly Lue, MD1, Rosalba Martignetti2, Joanna Mi, NP1, Alison Moskowitz, MD1, Colette Owens, MD1, Sean Plummer2, Madeline Puccio2, Gilles Salles, MD, PhD1, Venkatraman Seshan, PhD1, Elizabeth Simkins2, Natalie Slupe1, Honglei Zhang, MD1, and Andrew D. Zelenetz, MD, PhD1 1. Memorial-Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA 2. Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA, USA </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29619 --> <article id="post-29634" class="publication--item post-29634 publication type-publication status-publish hentry publication_categories-mrd publication_tags-j-clin-oncol"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://ascopubs.org/doi/10.1200/JCO.24.00321">Outcomes After Brexucabtagene Autoleucel Administered as a Standard Therapy for Adults With Relapsed/Refractory B-Cell ALL</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Roloff G, et al. </div><!-- publication--contributors --> <div class="publication--tags"> J Clin Oncol </div> <!-- publication--tags --> <div class="publication--date"> October 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Gregory W. Roloff, MD1; Ibrahim Aldoss, MD2 ; Noam E. Kopmar, MD3 ; Chenyu Lin, MD4 ; Simone E. Dekker, MD, PhD5; Vishal K. Gupta, MD6 ; Timothy E. O’Connor, MD7; Nikeshan Jeyakumar, MD8; Ibrahim N. Muhsen, MD9 ; Yannis Valtis, MD10 ; Naveed Ahmed, DO10; Amy Zhang, MPH8; Katharine Miller, PhD, MPH8 ; Kaitlyn C. Dykes, MD11; Mohamed Ahmed, MD12; Evan C. Chen, MD13 ; Santiago Mercadal, MD14 ; Marc Schwartz, MD15; Sean I. Tracy, MD, PhD16 ; Bhagirathbhai Dholaria, MBBS17 ; Akash Mukherjee, MD18; Minoo Battiwalla, MD, MS19 ; Aaron C. Logan, MD, PhD20 ; Abdullah Ladha, MD21 ; Caitlin Guzowski, MBA22; Rasmus T. Hoeg, MD23; Talal Hilal, MBBCh24 ; Jozal Moore, MD25; Matthew P. Connor, MD26 ; LaQuisa C. Hill, MD27 ; Stephanie B. Tsai, MD7; Joshua P. Sasine, MD, PhD12 ; Melhem M. Solh, MD22 ; Vamsi K. Kota, MD28 ; Divya Koura, MD11; Muthu Veeraputhiran, MD18; Jessica T. Leonard, MD5; Noelle V. Frey, MD, MS26 ; Jae H. Park, MD10 ; Marlise R. Luskin, MD, MSCE13 ; Veronika Bachanova, MD, PhD16; Ahmed Galal, MD4; Vinod Pullarkat, MD2; Wendy Stock, MD1 ; Ryan D. Cassaday, MD3 ; Bijal D. Shah, MD, MS29; Rawan Faramand, MD29; and Lori Muffly, MD, MS8 ; on behalf of the ROCCA Consortium 1Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 2Division of Leukemia, Department of Hematology and Hematopoitic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 3Division of Hematology and Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA 4Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC 5Division of Hematology-Oncology, Knight Cancer Institute, Oregon Health &amp; Science University, Portland, OR 6Division of Hematology &amp; Oncology, University of California Los Angeles, Los Angeles, CA 7Division of Hematology/Oncology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 8Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA 9Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX 10Memorial Sloan Kettering Cancer Center, New York, NY 11Department of Medicine, Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, San Diego, CA 12Cedars-Sinai Medical Center, Los Angeles, CA 13Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA 14Transplant and Cellular Therapy Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 15University of Colorado Anschutz School of Medicine, Aurora, CO 16Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 17Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 18University of Arkansas Medical Center, Little Rock, AK 19Sarah Cannon Transplant and Cell Therapy Network, Nashville, TN 20Department of Medicine, Division of Hematology and Blood and Marrow Transplantation, University of California, San Francisco, CA 21Department of Hematology, Norris Cancer Center, University of Southern California, Los Angeles, CA 22Blood and Marrow Transplant Program, Northside Hospital, Atlanta, GA 23Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento, CA 24Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ 25Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 26Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 27Center for Cell and Gene Therapy, Baylor College of Medicine and Houston Methodist Hospital, Houston, TX 28Georgia Cancer Center, Augusta University, Augusta, GA 29Moffitt Cancer Center, Tampa, FL </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29634 --> <article id="post-29620" class="publication--item post-29620 publication type-publication status-publish hentry publication_categories-mrd publication_tags-clinical-lymphoma-myeloma-leukemia"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://pubmed.ncbi.nlm.nih.gov/39477701/">Measurable Residual Disease Testing Following Non-Intensive Chemoimmunotherapy Is Predictive of Need for Maintenance Therapy in Previously Untreated Mantle Cell Lymphoma: A Wisconsin Oncology Network Study</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Chang J, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Clinical Lymphoma Myeloma &amp; Leukemia </div> <!-- publication--tags --> <div class="publication--date"> October 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Julie E. Chang MD,1 Danielle McQuinn MD, 1 Meredith Hyun MS,2 KyungMann Kim PhD,2,3 Vaishalee P Kenkre MD,1 Saurabh A. Rajguru MD,1 Priyanka A. Pophali MD,1 Mariah Endres,3 Mitch Howard,3 Tim Wassenaar MD, MS,4 Ruth Callaway Warren MD,5 Ryan J Mattison MD,1 Kari B Wisinski MD1 Christopher D Fletcher MD1 1Department of Medicine, University of Wisconsin School of Medicine and Public Health 2Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health 3University of Wisconsin Carbone Cancer Center, Madison, WI 4ProHealth Care, Waukesha, WI 5Green Bay Oncology, St. Vincent Regional Cancer Center, Green Bay, WI </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29620 --> <article id="post-29617" class="publication--item post-29617 publication type-publication status-publish hentry publication_categories-mrd publication_tags-blood-advances"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://pubmed.ncbi.nlm.nih.gov/39024542/">A.R.R.O.W.2: once- vs twice-weekly carfilzomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Dimopoulos M, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Blood Advances </div> <!-- publication--tags --> <div class="publication--date"> October 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Meletios A. Dimopoulos,1 Daniel Coriu,2,3 Sosana Delimpasi,4 Ivan ˇ Spiˇcka,5 Terry Upchurch,6 Belle Fang,6 Rakhshandra Talpur,6 Edward Faber,7 Meral Beksac,8 and Xavier Leleu9 1Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; 2Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania; 3Department of Haematology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 4Department of Hematology and Bone Marrow Transplantation Unit, Evangelismos Hospital, Athens, Greece; 5First Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University and General Hospital, Prague, Czech Republic; 6Amgen Inc, Thousand Oaks, CA; 7Oncology Hematology Care, Inc, Cincinnati, OH; 8Hematology, Ankara Liv Hospital, Istinye University, Ankara, Turkey; and 9Department of Hematology and Cellular Therapy, CIC U1402 CHU de Poitiers, Poitiers, France </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29617 --> <article id="post-29618" class="publication--item post-29618 publication type-publication status-publish hentry publication_categories-mrd publication_tags-blood-cancer-journal"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://www.nature.com/articles/s41408-024-01156-x">Discontinuation of maintenance therapy in multiple myeloma guided by multimodal measurable residual disease negativity(MRD2STOP)</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Derman B, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Blood Cancer Journal </div> <!-- publication--tags --> <div class="publication--date"> October 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Benjamin A. Derman1✉, Ajay Major 2, Jennifer Cooperrider1, Ken Jiang1, Aubrianna Ramsland1, Theodore Karrison3, Tadeusz Kubicki 1 and Andrzej J. Jakubowiak1 1Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA. 2Division of Hematology, University of Colorado School of Medicine, Aurora, CO, USA. 3Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29618 --> <article id="post-29633" class="publication--item post-29633 publication type-publication status-publish hentry publication_categories-mrd publication_tags-blood"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://ashpublications.org/blood/article/doi/10.1182/blood.2024025945/518044/Safety-and-Efficacy-of-Standard-of-Care">Safety and Efficacy of Standard of Care Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Sidana S, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Blood </div> <!-- publication--tags --> <div class="publication--date"> October 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Surbhi Sidana1*, Krina K. Patel2*, Lauren C. Peres*3, Radhika Bansal4, Mehmet H. Kocoglu5, Leyla Shune6, Shebli Atrash7, Kinaya Smith8, Shonali Midha9, Christopher Ferreri,7, Binod Dhakal8, Danai Dima10, Patrick Costello9, Charlotte Wagner11, Ran Reshef12, Hitomi Hosoya1, Lekha Mikkilineni1, Djordje Atanackovic5, Saurabh Chhabra13, Ricardo Parrondo14, Omar Nadeem9, Hashim Mann,15 Nilesh Kalariya2, Vanna Hovanky1, Gabriel De Avila3, Ciara L Freeman3, Frederick L. Locke3, Melissa Alsina3, Sandy Wong16, Megan Herr17, Myo Htut18, Joseph McGuirk6, Douglas W. Sborov11, Jack Khouri10, Thomas Martin16, Murali Janakiram18*, Yi Lin4*, and Doris K. Hansen3* *S.S, K.K.P, L.C.P are co-first authors; M.J, Y.L, and D.K.H are co-senior authors. Affiliations: 1. Stanford University School of Medicine 2. The University of Texas MD Anderson Cancer Center, 3. Moffitt Cancer Center, 4. Mayo Clinic, Rochester, 5. University of Maryland School of Medicine, 6. University of Kansas Medical Center, 7. Levine Cancer Institute, 8. Medical College of Wisconsin, 9. Dana-Farber Cancer Institute, 10. Cleveland Clinic Taussig Cancer Center. 11. Huntsman Cancer Institute at the University of Utah, 12. Columbia University Irving Medical Center, 13. Division of Hematology/Oncology, Department of Medicine, Mayo Clinic, Phoenix, Arizona, 14. Mayo Clinic, Jacksonville 15. Virginia Commonwealth University, 16. University of California San Francisco, 17. Rosewell Park Cancer Center, 18. City of Hope Comprehensive Cancer Center, </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29633 --> <article id="post-29621" class="publication--item post-29621 publication type-publication status-publish hentry publication_categories-mrd publication_tags-blood"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://ashpublications.org/blood/article/doi/10.1182/blood.2024025746/518000/Daratumumab-with-lenalidomide-as-maintenance-after">Daratumumab with lenalidomide as maintenance after transplant in newly diagnosed multiple myeloma: the AURIGA study</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Badros A, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Blood </div> <!-- publication--tags --> <div class="publication--date"> September 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Ashraf Badros,1 Laahn Foster,2 Larry D. Anderson Jr,3 Chakra P. Chaulagain,4 Erin Pettijohn,5 Andrew J. Cowan,6 Caitlin Costello,7 Sarah Larson,8 Douglas W. Sborov,9 Kenneth H. Shain,10 Rebecca Silbermann,11 Nina Shah,12* Alfred Chung,12 Maria Krevvata,13 Huiling Pei,14 Sharmila Patel,15 Vipin Khare,15 Annelore Cortoos,15 Robin Carson,13 Thomas S. Lin,15 and Peter Voorhees16 1Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, United States; 2Division of Hematology Oncology, University of Virginia, Charlottesville, VA, United States; 3Myeloma, Waldenstrom’s and Amyloidosis Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States; 4Department of Hematology and Oncology, Myeloma and Amyloidosis Program, Cleveland Clinic Florida, Weston, FL, United States; 5Cancer and Hematology Centers of Western Michigan, Grand Rapids, MI, United States; 6Division of Medical Oncology, Fred Hutch Cancer Center/University of Washington, Seattle, WA, United States; 7Moores Cancer Center, University of California San Diego, La Jolla, CA, United States; 8Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 9Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States; 10Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, United States; 11Knight Cancer Institute, Oregon Health &amp; Science University, Portland, OR, United States; 12Department of Medicine, University of California San Francisco, San Francisco, CA, United States; 13Janssen Research &amp; Development, LLC, Spring House, PA, United States; 14Janssen Research &amp; Development, LLC, Titusville, NJ, United States; 15Janssen Scientific Affairs, LLC, a Johnson &amp; Johnson company, Horsham, PA, United States; 16Levine Cancer Institute, Atrium Health Wake Forest University School of Medicine, Charlotte, NC, United States. </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29621 --> <article id="post-29615" class="publication--item post-29615 publication type-publication status-publish hentry publication_categories-mrd publication_tags-leukemia"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://www.nature.com/articles/s41375-024-02410-8">Epcoritamab in relapsed/refractory large B-cell lymphoma:2-year follow-up from the pivotal EPCORE NHL-1 trial</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Thieblemont C, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Leukemia </div> <!-- publication--tags --> <div class="publication--date"> September 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Catherine Thieblemont 1✉, Yasmin H. Karimi2, Herve Ghesquieres3, Chan Y. Cheah4, Michael Roost Clausen5, David Cunningham6, Wojciech Jurczak 7, Young Rok Do8, Robin Gasiorowski 9, David John Lewis10, Tae Min Kim 11, Marjolein van der Poel12, Michelle Limei Poon13, Tatyana Feldman14, Kim M. Linton15, Anna Sureda 16, Martin Hutchings17, Minh H. Dinh 18, Nurgul Kilavuz19, David Soong19, Thomas Mark20, Mariana Sacchi19, Tycel Phillips21,23 and Pieternella J. Lugtenburg22 1Assistance Publique &amp; Hôpitaux de Paris (APHP), Hôpital Saint-Louis, Hémato-oncologie, Université de Paris, Paris, France. 2Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA. 3Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France. 4Sir Charles Gairdner Hospital and the University of Western Australia, Nedlands, Australia. 5Vejle Hospital, Vejle, Denmark. 6The Royal Marsden NHS Foundation Trust, Sutton, UK. 7MSC National Research Institute of Oncology, Kraków, Poland. 8Keimyung University Dongsan Medical Center, Daegu, Republic of Korea. 9Concord Hospital, University of Sydney, Sydney, Australia. 10University Hospitals Plymouth NHS Trust, Derriford Hospital, Plymouth, UK. 11Seoul National University Hospital, Seoul, Republic of Korea. 12Lunenburg Lymphoma Phase I/II Consortium-HOVON/LLPC, Maastricht, Department of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. 13National University Hospital, Singapore, Singapore. 14John Theurer Cancer Center at Hackensack Meridian Health, Hackensack Meridian Health School of Medicine, Hackensack, NJ, USA. 15The Christie NHS Foundation Trust, Manchester Cancer Research Centre, and Division of Cancer Sciences, University of Manchester, Manchester, UK. 16Clinical Hematology Department, Institut Català d’Oncologia – L’Hospitalet, IDIBELL, Universitat de Barcelona, Barcelona, Spain. 17Rigshospitalet and University of Copenhagen, Copenhagen, Denmark. 18AbbVie, North Chicago, IL, USA. 19Genmab, Plainsboro, NJ, USA. 20Genmab, Copenhagen, Denmark. 21University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. 22Lunenburg Lymphoma Phase I/II Consortium-HOVON/LLPC, Erasmus MC Cancer Institute, Department of Hematology, University Medical Center, Rotterdam, The Netherlands. 23Present address: City of Hope, Duarte, CA, USA. ✉email: catherine.thieblemont@aphp.fr </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29615 --> <article id="post-29456" class="publication--item post-29456 publication type-publication status-publish hentry publication_categories-mrd publication_tags-lancet-oncology"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://pubmed.ncbi.nlm.nih.gov/39270702/">Atezolizumab, venetoclax, and obinutuzumab combination in Richter transformation diffuse large B-cell lymphoma(MOLTO): a multicentre, single-arm, phase 2 trial</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Tedeschi A, et al. </div><!-- publication--contributors --> <div class="publication--tags"> Lancet Oncology </div> <!-- publication--tags --> <div class="publication--date"> September 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Alessandra Tedeschi*, Anna Maria Frustaci*, Adalgisa Condoluci, Marta Coscia, Roberto Chiarle, Pier Luigi Zinzani, Marina Motta, Gianluca Gaidano, Giulia Quaresmini, Lydia Scarfò, Gioacchino Catania, Marina Deodato, Rebecca Jones, Valentina Tabanelli, Valentina Griggio, Georg Stüssi, Angelica Calleri, Katia Pini, Roberto Cairoli, Thorsten Zenz, Alessio Signori, Emanuele Zucca, Davide Rossi, Marco Montillo Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Niguarda Cancer Center, Milan, Italy (A Tedeschi MD, A M Frustaci MD, M Deodato MD, R Cairoli MD, M Montillo MD); Department of Oncology, Institute of Oncology Research, Bellinzona, Switzerland (A Condoluci MD, Prof D Rossi MD, K Pini BS, Prof E Zucca MD); Clinic of Hematology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland (A Condoluci, Prof D Rossi, Prof G Stüssi MD, Prof E Zucca MD); University Division of Hematology, AOU Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy (R Jones MD, V Griggio PhD); Department of Oncology ASST Sette Laghi,\ Ospedale di Circolo, Varese, Italy (Prof M Coscia MD);Division of Hematopathology, IEO European Institute of Oncology IRCCS, Milan, Italy (Prof R Chiarle MD, V Tabanelli MD, A Calleri PhD); Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy (Prof R Chiarle); Department of Pathology, Boston Children’s Hospital, Boston, MA, USA (Prof R Chiarle); Azienda Ospedaliero–Universitaria di Bologna, Istituto di Ematologia “L e A Seràgnoli”, Bologna, Italy </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29456 --> <article id="post-29351" class="publication--item post-29351 publication type-publication status-publish hentry publication_categories-covid publication_categories-immune-medicine publication_tags-annals-of-clinical-and-translational-neurology"> <header class="publication--header"> <h2 class="publication--title"><a target="_blank" rel="nofollow noopener" href="https://www.medrxiv.org/content/10.1101/2024.01.23.24301671v1.">Longitudinal study of immunity to SARS-CoV2 inocrelizumab-treated MS patients up to 2 years after COVID-19 vaccination</a></h2> </header><!-- .publication--header --> <div class="publication--meta"> <div class="publication--contributors"> Kister I., et al. </div><!-- publication--contributors --> <div class="publication--tags"> Annals of Clinical and Translational Neurology </div> <!-- publication--tags --> <div class="publication--date"> August 2024 </div> <!-- publication--date --> </div><!-- .publication--meta --> <div class="publication--authors"> <div class="publication--authors-toggle js-authors-collapse-toggle"><span class="fa-solid fa-plus publication--authors-icon"></span> Authors and Affiliates</div> <div class="publication--authors-content js-authors-collapse"> Ilya Kister, Ryan Curtin, Amanda L. Piquet, Tyler Borko, Jinglan Pei, Barbara L Banbury, Tamar E. Bacon, Angie Kim, Michael Tuen, Yogambigai Velmurugu, Samantha Nyovanie, Sean Selva, Marie I. Samanovic, Mark J. Mulligan, Yury Patskovsky, Jessica Priest, Mark Cabatingan, Ryan C. Winger, Michelle Krogsgaard &amp; Gregg J. Silverman </div><!-- publication--authors-content--> </div><!-- publication--authors --> </article><!-- #post-29351 --> <div class="publication--navigation"> <span class="publication--navigation publication--navigation-previous publication--navigation-empty"><span>Previous</span></span> <span class="publication--navigation publication--navigation-next"><a href="https://www.adaptivebiotech.com/publications/?sf_paged=2" >Next</a></span> </div> </div> </main><!-- #main --> </div><!-- #primary --> </div><!-- #content --> <div class="sub-footer" role="complementary"> <div class="container"> <div id="block-cta_footer" class="block block--cta fill fill--navy "> <div class="cta__content"> <h2 class="h3--mimic">The latest from Adaptive</h2> </div> <a tabindex="" class="btn btn--reverse" href="https://investors.adaptivebiotech.com/news-events/news-releases" aria-label="News Releases: The latest from Adaptive" target="_self" rel=""> News Releases </a> </div> </div> </div> <footer id="bt-footer" class="site-footer"> <div class="container"> <div class="site-footer__nav"> <div id="footer-1" class="footer__column"> <section id="nav_menu-2" class="widget widget_nav_menu"><h2 class="widget-title">Immune Medicine</h2><div class="menu-immune-medicine-menu-container"><ul id="menu-immune-medicine-menu" class="menu"><li id="menu-item-20905" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20905"><a href="https://www.adaptivebiotech.com/our-platform/">Immune Medicine Platform</a></li> <li id="menu-item-20906" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20906"><a href="https://www.adaptivebiotech.com/the-adaptive-immune-system/">The Adaptive Immune System</a></li> <li id="menu-item-20907" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20907"><a href="https://www.adaptivebiotech.com/tcr-antigen-map/">TCR Antigen Map</a></li> <li id="menu-item-20910" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20910"><a href="https://adaptivebiotech.com/publications">Publications</a></li> </ul></div></section><section id="nav_menu-4" class="widget widget_nav_menu"><h2 class="widget-title">Pharma Services</h2><div class="menu-pharma-services-container"><ul id="menu-pharma-services" class="menu"><li id="menu-item-27308" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27308"><a href="https://www.adaptivebiotech.com/research-development-applications/">Research &#038; Development Applications</a></li> <li id="menu-item-27309" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27309"><a href="https://www.adaptivebiotech.com/adaptive-immunosequencing/">Adaptive Immunosequencing</a></li> </ul></div></section><section id="nav_menu-3" class="widget widget_nav_menu"><h2 class="widget-title">Drug Discovery</h2><div class="menu-drug-discovery-menu-container"><ul id="menu-drug-discovery-menu" class="menu"><li id="menu-item-27310" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27310"><a href="https://www.adaptivebiotech.com/tcr-therapeutics/">TCR Therapeutics</a></li> <li id="menu-item-27311" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27311"><a href="https://www.adaptivebiotech.com/antibody-therapeutics/">Antibody Therapeutics</a></li> <li id="menu-item-27312" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27312"><a href="https://www.adaptivebiotech.com/target-discovery/">Target Discovery</a></li> </ul></div></section> </div> <div id="footer-2" class="footer__column"> <section id="nav_menu-12" class="widget widget_nav_menu"><h2 class="widget-title">MRD</h2><div class="menu-mrd-menu-container"><ul id="menu-mrd-menu" class="menu"><li id="menu-item-20915" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20915"><a href="https://adaptivebiotech.com/pipeline#diagnostics">Clinical Portfolio &#038; Pipeline</a></li> <li id="menu-item-20916" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20916"><a href="https://adaptivebiotech.com/publications">Publications</a></li> </ul></div></section><section id="nav_menu-6" class="widget widget_nav_menu"><h2 class="widget-title">Clinical Diagnostics</h2><div class="menu-clinical-diagnostics-clonoseq-menu-container"><ul id="menu-clinical-diagnostics-clonoseq-menu" class="menu"><li id="menu-item-20917" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20917"><a href="https://www.clonoseq.com/">clonoSEQ</a></li> </ul></div></section> </div> <div id="footer-3" class="footer__column"> <section id="nav_menu-11" class="widget widget_nav_menu"><h2 class="widget-title">News &#038; Events</h2><div class="menu-news-events-menu-container"><ul id="menu-news-events-menu" class="menu"><li id="menu-item-20918" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20918"><a href="https://investors.adaptivebiotech.com/news-events/news-releases">Press Releases</a></li> <li id="menu-item-20919" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20919"><a href="https://www.adaptivebiotech.com/media-resources/">Media Resources</a></li> <li id="menu-item-20920" class="menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-20920"><a href="https://www.adaptivebiotech.com/blog/">Blog</a></li> <li id="menu-item-20921" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20921"><a href="https://www.adaptivebiotech.com/conferences-events/">Conferences &#038; Events</a></li> </ul></div></section> </div> <div id="footer-4" class="footer__column"> <section id="block-2" class="widget widget_block"> <h2 class="wp-block-heading">Our Science</h2> </section><section id="nav_menu-8" class="widget widget_nav_menu"><h2 class="widget-title">Publications</h2><div class="menu-publications-menu-container"><ul id="menu-publications-menu" class="menu"><li id="menu-item-20927" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20927"><a href="https://adaptivebiotech.com/publications">Research Publications</a></li> </ul></div></section><section id="nav_menu-13" class="widget widget_nav_menu"><h2 class="widget-title">Credentials</h2><div class="menu-credentials-container"><ul id="menu-credentials" class="menu"><li id="menu-item-27314" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27314"><a href="https://www.adaptivebiotech.com/licenses-and-accreditation/">Licenses &#038; Accreditation</a></li> </ul></div></section><section id="nav_menu-9" class="widget widget_nav_menu"><h2 class="widget-title">Medical</h2><div class="menu-medical-menu-container"><ul id="menu-medical-menu" class="menu"><li id="menu-item-20925" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20925"><a href="https://www.adaptivebiotech.com/medical-affairs/">Medical Affairs</a></li> <li id="menu-item-20926" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20926"><a href="https://www.adaptivebiotech.com/medical-information/">Medical Information</a></li> <li id="menu-item-20924" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20924"><a href="https://www.adaptivebiotech.com/congress-data-presentations/">Data &#038; Congress</a></li> </ul></div></section> </div> <div id="footer-5" class="footer__column"> <section id="nav_menu-10" class="widget widget_nav_menu"><h2 class="widget-title">About Us</h2><div class="menu-about-us-menu-container"><ul id="menu-about-us-menu" class="menu"><li id="menu-item-20929" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20929"><a href="https://www.adaptivebiotech.com/who-we-are/">Who We Are</a></li> <li id="menu-item-20931" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20931"><a href="https://www.adaptivebiotech.com/our-story/">Our Story</a></li> <li id="menu-item-20932" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20932"><a href="https://www.adaptivebiotech.com/timeline/">Innovation Timeline</a></li> <li id="menu-item-20930" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20930"><a href="https://www.adaptivebiotech.com/adaptive-leadership/">Leadership</a></li> <li id="menu-item-20933" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20933"><a href="https://investors.adaptivebiotech.com/">Investor Relations</a></li> <li id="menu-item-20934" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-20934"><a href="https://investors.adaptivebiotech.com/news-events/news-releases">Newsroom</a></li> <li id="menu-item-20935" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20935"><a href="https://www.adaptivebiotech.com/contact-us/">Contact</a></li> <li id="menu-item-20936" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20936"><a href="https://www.adaptivebiotech.com/career-listings/">Careers</a></li> </ul></div></section> </div> </div><!-- .site-footer__nav --> <div class="site-footer__info"> <div class="footer__image-phone"> <img src="https://www.adaptivebiotech.com/wp-content/uploads/2020/12/adaptive_logo_gray_tm.svg" class="attachment-full size-full" alt="Logo for Adaptive Biotechnologies" decoding="async" loading="lazy" /> Diagnostics (888) 552-8988 | Corporate (206) 659-0067 <img width="350" height="144" src="https://www.adaptivebiotech.com/wp-content/uploads/2023/07/cap-accredited-2.webp" class="attachment-full size-full" alt="" decoding="async" loading="lazy" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/07/cap-accredited-2.webp 350w, https://www.adaptivebiotech.com/wp-content/uploads/2023/07/cap-accredited-2-300x123.webp 300w" sizes="(max-width: 350px) 100vw, 350px" /> </div><!-- .footer__image-phone --> <div class="footer__social-copy-nav"> <div class="footer__social-copy"> <div class="footer__social"> <a href="https://www.facebook.com/pages/Adaptive-Biotechnologies/125974454184631" class="social social--facebook" aria-label="Open in a new window" target="_blank"> <span class="screen-reader-text">View our facebook'</span> </a> <a href="https://www.youtube.com/channel/UCmTjXgdI6GAIkILAOgRk8hA/feed" class="social social--youtube" aria-label="Open in a new window" target="_blank"> <span class="screen-reader-text">View our youtube'</span> </a> <a href="https://twitter.com/AdaptiveBiotech" class="social social--twitter" aria-label="Open in a new window" target="_blank"> <span class="screen-reader-text">View our twitter'</span> </a> <a href="https://www.instagram.com/adaptivebiotech" class="social social--instagram" aria-label="Open in a new window" target="_blank"> <span class="screen-reader-text">View our instagram'</span> </a> <a href="https://www.linkedin.com/company/1252860" class="social social--linkedin" aria-label="Open in a new window" target="_blank"> <span class="screen-reader-text">View our linkedin'</span> </a> </div><!-- .footer__social --> </div><!-- .footer__social-copy --> <div class="menu-legal-menu-container"><ul id="footer-legal-menu" class="menu"><li id="menu-item-27722" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27722"><a href="https://www.adaptivebiotech.com/sitemap/">Sitemap</a></li> <li id="menu-item-20946" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-20946"><a rel="privacy-policy" href="https://www.adaptivebiotech.com/online-privacy-policy/">Privacy Policy</a></li> <li id="menu-item-20945" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20945"><a href="https://www.adaptivebiotech.com/cookie-policy/">Cookie Policy</a></li> <li id="menu-item-27430" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-27430"><a href="https://www.adaptivebiotech.com/notice-at-collection/">Notice at Collection</a></li> <li id="menu-item-20948" class="js-do-not-sell menu-item menu-item-type-custom menu-item-object-custom menu-item-20948"><a>Do Not Sell or Share My Info</a></li> <li id="menu-item-20947" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20947"><a href="https://www.adaptivebiotech.com/terms-of-service/">Terms of Service</a></li> <li id="menu-item-20944" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-20944"><a href="https://www.adaptivebiotech.com/code-of-conduct/">Code of Conduct</a></li> </ul></div> </div><!-- .footer__social-copy-nav --> <div class="footer__copyright"> © Adaptive Biotechnologies. All Rights Reserved. </div> </div><!-- .site-footer__info --> </div><!-- .container --> </footer><!-- #colophon --> </div><!-- #page --> <style id='wp-block-heading-inline-css' type='text/css'> h1.has-background,h2.has-background,h3.has-background,h4.has-background,h5.has-background,h6.has-background{padding:1.25em 2.375em}h1.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h1.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h2.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h2.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h3.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h3.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h4.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h4.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h5.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h5.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h6.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h6.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]){rotate:180deg} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #FFF;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--color--navy: #0b2662;--wp--preset--color--teal: #00ac9f;--wp--preset--color--green: #3daf7b;--wp--preset--color--green-a-11-y: #2e855e;--wp--preset--color--blue: #2154d7;--wp--preset--color--blue-light: #3bb5fd;--wp--preset--color--blue-pale: #bae5ff;--wp--preset--color--gold: #eaaa3c;--wp--preset--color--purple: #5a3c8a;--wp--preset--color--dark-grey: #3f454f;--wp--preset--color--light-grey: #f7f7fb;--wp--preset--color--black-alt: #2c2c2c;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--font-family--dm-sans: 'DM Sans', sans-serif;--wp--preset--font-family--axiforma: Axiforma, sans-serif;--wp--preset--font-family--tt-norms: 'TT Norms Pro', sans-serif;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}.wp-block-button .wp-block-button__link{--wp--preset--color--green: #3daf7b;--wp--preset--color--green-a-11-y: #2e855e;--wp--preset--color--blue: #2154d7;--wp--preset--color--blue-light: #3bb5fd;--wp--preset--color--black-alt: #2c2c2c;--wp--preset--color--white: #FFF;}.wp-block-heading{--wp--preset--font-size--extra-small: 24px;--wp--preset--font-size--extra-large: 50px;}:root { --wp--style--global--content-size: 875px;--wp--style--global--wide-size: 1460px; }:where(body) { margin: 0; }.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }.wp-site-blocks > .alignright { float: right; margin-left: 2em; }.wp-site-blocks > .aligncenter { justify-content: center; margin-left: auto; margin-right: auto; }:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}.is-layout-flow > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-flow > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-flow > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-constrained > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-constrained > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > :where(:not(.alignleft):not(.alignright):not(.alignfull)){max-width: var(--wp--style--global--content-size);margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignwide{max-width: var(--wp--style--global--wide-size);}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}body{padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}a:where(:not(.wp-element-button)){text-decoration: underline;}:root :where(.wp-element-button, .wp-block-button__link){background-color: #32373c;border-width: 0;color: #fff;font-family: inherit;font-size: inherit;line-height: inherit;padding: calc(0.667em + 2px) calc(1.333em + 2px);text-decoration: none;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-navy-color{color: var(--wp--preset--color--navy) !important;}.has-teal-color{color: var(--wp--preset--color--teal) !important;}.has-green-color{color: var(--wp--preset--color--green) !important;}.has-green-a-11-y-color{color: var(--wp--preset--color--green-a-11-y) !important;}.has-blue-color{color: var(--wp--preset--color--blue) !important;}.has-blue-light-color{color: var(--wp--preset--color--blue-light) !important;}.has-blue-pale-color{color: var(--wp--preset--color--blue-pale) !important;}.has-gold-color{color: var(--wp--preset--color--gold) !important;}.has-purple-color{color: var(--wp--preset--color--purple) !important;}.has-dark-grey-color{color: var(--wp--preset--color--dark-grey) !important;}.has-light-grey-color{color: var(--wp--preset--color--light-grey) !important;}.has-black-alt-color{color: var(--wp--preset--color--black-alt) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-navy-background-color{background-color: var(--wp--preset--color--navy) !important;}.has-teal-background-color{background-color: var(--wp--preset--color--teal) !important;}.has-green-background-color{background-color: var(--wp--preset--color--green) !important;}.has-green-a-11-y-background-color{background-color: var(--wp--preset--color--green-a-11-y) !important;}.has-blue-background-color{background-color: var(--wp--preset--color--blue) !important;}.has-blue-light-background-color{background-color: var(--wp--preset--color--blue-light) !important;}.has-blue-pale-background-color{background-color: var(--wp--preset--color--blue-pale) !important;}.has-gold-background-color{background-color: var(--wp--preset--color--gold) !important;}.has-purple-background-color{background-color: var(--wp--preset--color--purple) !important;}.has-dark-grey-background-color{background-color: var(--wp--preset--color--dark-grey) !important;}.has-light-grey-background-color{background-color: var(--wp--preset--color--light-grey) !important;}.has-black-alt-background-color{background-color: var(--wp--preset--color--black-alt) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-navy-border-color{border-color: var(--wp--preset--color--navy) !important;}.has-teal-border-color{border-color: var(--wp--preset--color--teal) !important;}.has-green-border-color{border-color: var(--wp--preset--color--green) !important;}.has-green-a-11-y-border-color{border-color: var(--wp--preset--color--green-a-11-y) !important;}.has-blue-border-color{border-color: var(--wp--preset--color--blue) !important;}.has-blue-light-border-color{border-color: var(--wp--preset--color--blue-light) !important;}.has-blue-pale-border-color{border-color: var(--wp--preset--color--blue-pale) !important;}.has-gold-border-color{border-color: var(--wp--preset--color--gold) !important;}.has-purple-border-color{border-color: var(--wp--preset--color--purple) !important;}.has-dark-grey-border-color{border-color: var(--wp--preset--color--dark-grey) !important;}.has-light-grey-border-color{border-color: var(--wp--preset--color--light-grey) !important;}.has-black-alt-border-color{border-color: var(--wp--preset--color--black-alt) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;}.has-dm-sans-font-family{font-family: var(--wp--preset--font-family--dm-sans) !important;}.has-axiforma-font-family{font-family: var(--wp--preset--font-family--axiforma) !important;}.has-tt-norms-font-family{font-family: var(--wp--preset--font-family--tt-norms) !important;}.wp-block-button .wp-block-button__link.has-green-color{color: var(--wp--preset--color--green) !important;}.wp-block-button .wp-block-button__link.has-green-a-11-y-color{color: var(--wp--preset--color--green-a-11-y) !important;}.wp-block-button .wp-block-button__link.has-blue-color{color: var(--wp--preset--color--blue) !important;}.wp-block-button .wp-block-button__link.has-blue-light-color{color: var(--wp--preset--color--blue-light) !important;}.wp-block-button .wp-block-button__link.has-black-alt-color{color: var(--wp--preset--color--black-alt) !important;}.wp-block-button .wp-block-button__link.has-white-color{color: var(--wp--preset--color--white) !important;}.wp-block-button .wp-block-button__link.has-green-background-color{background-color: var(--wp--preset--color--green) !important;}.wp-block-button .wp-block-button__link.has-green-a-11-y-background-color{background-color: var(--wp--preset--color--green-a-11-y) !important;}.wp-block-button .wp-block-button__link.has-blue-background-color{background-color: var(--wp--preset--color--blue) !important;}.wp-block-button .wp-block-button__link.has-blue-light-background-color{background-color: var(--wp--preset--color--blue-light) !important;}.wp-block-button .wp-block-button__link.has-black-alt-background-color{background-color: var(--wp--preset--color--black-alt) !important;}.wp-block-button .wp-block-button__link.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.wp-block-button .wp-block-button__link.has-green-border-color{border-color: var(--wp--preset--color--green) !important;}.wp-block-button .wp-block-button__link.has-green-a-11-y-border-color{border-color: var(--wp--preset--color--green-a-11-y) !important;}.wp-block-button .wp-block-button__link.has-blue-border-color{border-color: var(--wp--preset--color--blue) !important;}.wp-block-button .wp-block-button__link.has-blue-light-border-color{border-color: var(--wp--preset--color--blue-light) !important;}.wp-block-button .wp-block-button__link.has-black-alt-border-color{border-color: var(--wp--preset--color--black-alt) !important;}.wp-block-button .wp-block-button__link.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.wp-block-heading.has-extra-small-font-size{font-size: var(--wp--preset--font-size--extra-small) !important;}.wp-block-heading.has-extra-large-font-size{font-size: var(--wp--preset--font-size--extra-large) !important;} </style> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-includes/js/jquery/ui/core.min.js?ver=1.13.3" id="jquery-ui-core-js"></script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-includes/js/jquery/ui/datepicker.min.js?ver=1.13.3" id="jquery-ui-datepicker-js"></script> <script type="text/javascript" id="jquery-ui-datepicker-js-after"> /* <![CDATA[ */ jQuery(function(jQuery){jQuery.datepicker.setDefaults({"closeText":"Close","currentText":"Today","monthNames":["January","February","March","April","May","June","July","August","September","October","November","December"],"monthNamesShort":["Jan","Feb","Mar","Apr","May","Jun","Jul","Aug","Sep","Oct","Nov","Dec"],"nextText":"Next","prevText":"Previous","dayNames":["Sunday","Monday","Tuesday","Wednesday","Thursday","Friday","Saturday"],"dayNamesShort":["Sun","Mon","Tue","Wed","Thu","Fri","Sat"],"dayNamesMin":["S","M","T","W","T","F","S"],"dateFormat":"MM d, yy","firstDay":1,"isRTL":false});}); /* ]]> */ </script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-content/themes/adaptive-biotech/assets/dist/js/runtime.59d71b009ea0c5f4a767.js?ver=1.1.0" id="kanopi-pack-runtime-js"></script> <script type="text/javascript" src="https://www.adaptivebiotech.com/wp-content/themes/adaptive-biotech/assets/dist/js/legacy.0adc66091992b7fd61d5.js?ver=1.1.0" id="kanopi-pack-legacy-js"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-06e8c0ddbe21bad7c96","applicationID":"189529644","transactionName":"M1AGYUIACEtZAUJZCwoaJVZECAlWFwNEUwwNQwEYQBQEVFEBV0QNC1s=","queueTime":0,"applicationTime":356,"atts":"HxcFFwoaG0U=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>

Pages: 1 2 3 4 5 6 7 8 9 10