CINXE.COM
KEGG REACTION: R04285
<!doctype html> <html><head> <title>KEGG REACTION: R04285</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1732429257"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1732429257"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1732429257" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } else{ obj.style.display = 'none'; clk.innerHTML = ' » '+show; } } } function toggleData(bobj,e){ var id = bobj.id.replace(/[^0-9]/g,''); var dt = document.getElementById('kcfd'+id); e.preventDefault(); if(!dt.style.display||dt.style.display == 'none'){ document.getElementById('kcfb'+id).innerHTML = 'Hide'; dt.style.display = 'block'; } else{ document.getElementById('kcfb'+id).innerHTML = 'Show'; dt.style.display = 'none'; } } function btn(bobj,img) { bobj.src = "/Fig/bget/button_" + img + ".gif"; } function btn_e(e) { e = e || event; var obj = e.target; var img = e.target.src; var img_base = img.replace(/\\/g,'/').replace(/(b|bd|bh)\.gif$/,''); if(e.type == 'mousedown'||e.type == 'touchstart'){ obj.src = img_base +'bd.gif'; } else if(e.type == 'mouseover'){ obj.src = img_base +'bh.gif'; } else if(e.type == 'mouseup'||e.type == 'touchend'){ obj.src = img_base +'b.gif'; } else if(e.type == 'mouseout'){ obj.src = img_base +'b.gif'; } } function init(){ for(var i=1;i<=1;i++){ if(document.getElementById('kcfb'+i)){ document.getElementById('kcfb'+i).onclick = function(e){toggleData(this,e);}; } } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="675"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg2.gif"></a></td><td> </td><td><a name="reaction:R04285"></a><font class="title2">REACTION: R04285</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_reaction.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">R04285 Reaction <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Definition</span></th> <td class="td20 defd"><div class="cel"><div class="cel">6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+<br> </div></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Equation</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/C04244">C04244</a> + <a href="/entry/C00006">C00006</a> <=> <a href="/entry/C03684">C03684</a> + <a href="/entry/C00005">C00005</a> + <a href="/entry/C00080">C00080</a><br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap"></span></th> <td class="td20 defd"><a href="/Fig/reaction/R04285.gif"><img border=0 name="img0" align="bottom" src="/Fig/reaction/R04285.gif" style="max-width:600px"></a></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction class</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/RC00001">RC00001</a> </span></td><td>C00005_C00006</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/RC00205">RC00205</a> </span></td><td>C03684_C04244</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Enzyme</span></th> <td class="td20 defd"><div class="cel"><a href="/entry/1.1.1.21">1.1.1.21</a> <a href="/entry/1.1.1.184">1.1.1.184</a> <a href="/entry/1.1.1.220">1.1.1.220</a><br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn00790+R04285">rn00790</a> </span></td><td>Folate biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn01100+R04285">rn01100</a> </span></td><td>Metabolic pathways</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td20 defd"><div class="cel"><span class="nowrap">Enzymatic reactions [BR:<a href="/brite/br08201+R04285">br08201</a>]<br> 1. Oxidoreductase reactions<br> 1.1 Acting on the CH-OH group of donors<br> 1.1.1 With NAD+ or NADP+ as acceptor<br> 1.1.1.21<br> R04285 6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+<br> 1.1.1.184<br> R04285 6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+<br> 1.1.1.220<br> R04285 6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+<br> IUBMB reaction hierarchy [BR:<a href="/brite/br08202+R04285">br08202</a>]<br> 1. Oxidoreductase reactions<br> 1.1.1.184<br> R03557 Secondary alcohol <=> Ketone<br> R04285 6-Lactoyl-5,6,7,8-tetrahydropterin <=> 6-Pyruvoyltetrahydropterin<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=R04285';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K00011">K00011</a> </span></td><td>aldehyde reductase [EC:<a href="/entry/1.1.1.21">1.1.1.21</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K00079">K00079</a> </span></td><td>carbonyl reductase 1 [EC:<a href="/entry/1.1.1.184">1.1.1.184</a> <a href="/entry/1.1.1.189">1.1.1.189</a> <a href="/entry/1.1.1.197">1.1.1.197</a>]</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">1 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/21867484">21867484</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Werner ER, Blau N, Thony B</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">Tetrahydrobiopterin: biochemistry and pathophysiology.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">Biochem J 438:397-414 (2011)<br>DOI:<a href="https://doi.org/10.1042/BJ20110293">10.1042/BJ20110293</a></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">2 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/9405351">9405351</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">EMBO J 16:7219-30 (1997)<br>DOI:<a href="https://doi.org/10.1093/emboj/16.24.7219">10.1093/emboj/16.24.7219</a></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">3 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/3536512">3536512</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Takikawa S, Curtius HC, Redweik U, Leimbacher W, Ghisla S.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">Eur J Biochem 161:295-302 (1986)<br>DOI:<a href="https://doi.org/10.1111/j.1432-1033.1986.tb10446.x">10.1111/j.1432-1033.1986.tb10446.x</a></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">RHEA: </span></td><td><a href="https://www.rhea-db.org/reaction?id=11775">11775</a></td></tr></table></td></tr> <tr><th class="th21 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td21 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?reaction+R04285';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>