CINXE.COM

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<span class="category_number highlight left">Cat. No. 7200</span> <span class="citations left"><a href="#citations" id="citation_count" class="scroll_to">7 Citations</a></span> <span class="submit_review left"><a href="/reviews/7200" rel="nofollow" class="btn btn-quaternary">Submit a Review</a></span> <span class="datasheet_link right"><a href="#ds_datasheets" class="scroll_to">Datasheet / COA / SDS</a></span> </div> <div class="product_wrapper"> <div class="product_ordering"> <form action="/products/tocriscreen-fda-approved-drugs_7200" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block"> <table class="add_to_cart"> <thead> <tr> <th class="ds_size_price_column">Pricing</th> <th class="ds_availability_column">Availability</th> <th class="ds_delivery_column"> </th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="7200/1 SET"> <td class="et_atc_results" colspan="3"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-72002f1set form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-72002f1set" name="catnum-7200%2F1+SET" value="" size="5" maxlength="3" /></div></td> </tr> </tbody> </table> <div class="ds_atc_pre_buttons"></div> <div class="ds_atc_buttons"> <button class="btn atc_print_quote_btn atc_hidden pull-left btn-default form-submit" style="display: none;" title="Enter quantities above and click to create a quote" type="submit" id="edit-print-quote" name="print_quote_btn" value="Print Quote">Print Quote</button> <a href="/support/bulk-quantities-form?catnum=7200" class="btn btn-secondary atc_hidden bulk_btn" style="display:none;" rel="nofollow" title="Competitive discounts on products purchased in bulk quantities">Bulk Orders</a> <button class="btn btn-primary atc_hidden atc_btn form-submit icon-before" style="display:none;" title="Enter quantities above and click to add to cart" type="submit" id="edit-add-to-cart" name="add_to_cart_btn" value="Add to Cart"><span class="icon glyphicon glyphicon-plus" aria-hidden="true"></span> Add to Cart</button> </div> <div class="ds_atc_post_buttons"></div> </div> <a href="/quote/instruments/ella-automated-immunoassay-system" class="btn btn-secondary atc_request_quote_simple_plex_assay" style="display:none" rel="nofollow">Request a Quote</a><input type="hidden" name="form_build_id" value="form-zSvwunywb-MtXPp0ytUNYEstQdbHw4PsluhQou6ObBc" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> <div class="product_image_wrapper"> <div class="product_image tocris_product_image">  <div id="tocris_product_images" class="carousel slide" data-ride="carousel">  <div class="carousel-inner" role="listbox"> <div class="item active"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Cat. No. 7200 - Tocriscreen FDA-Approved Drugs Library" href="https://resources.tocris.com/images/datasheets/7200_tocriscreen-fda-approved-drugs-library.jpg"> <img src="https://resources.tocris.com/images/datasheets/7200_tocriscreen-fda-approved-drugs-library.jpg" class="img-fluid" alt="Tocriscreen FDA-Approved Drugs logo" title="Tocriscreen FDA-Approved Drugs logo"> </a> </div> </div> </div> </div> </div> </div> <div class="product_info_wrapper"> <div class="product_info"> <span class="highlight">Description:</span> Drug repurposing library; a library of 190 compounds equivalent to active components of drug formulations approved by the FDA (100 μL 10 mM DMSO solutions) </div> </div> </div> <div class="tabbed_content"><div class="tab_menu"><div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details"><span>Datasheet</span></div><div class="tab tab_2" data-tab="2" data-tabname="product-citations"><span>Citations (7)</span></div><div class="tab tab_3" data-tab="3" data-tabname="product-reviews"><span>Reviews</span></div><div class="tab tab_4" data-tab="4" data-tabname="product-literature"><span>Literature (1)</span></div></div><div class="tab_content tab_1 tab_open" data-tab="1"><a id="product-details"></a><div> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to" href="#ds_biological_activity">Biological Activity</a> <a class="btn btn-quaternary scroll_to" href="#ds_technical_data">Technical Data</a> <a class="btn btn-quaternary scroll_to" href="#ds_datasheets">Datasheets</a> <a class="btn btn-quaternary scroll_to" href="#ds_reference_data">References</a> </div> <div id="ds_biological_activity" class="datasheet_section"> <h2>Biological Activity for Tocriscreen FDA-Approved Drugs Library</h2> <p>Tocriscreen FDA-Approved Drugs Library is a library of 190 compounds equivalent to the pharmacologically active components of drug formulations approved by the FDA. Compounds supplied pre-dissolved in DMSO (100 μL, 10 mM solution). Contains compounds covering a diverse range of pharmaceutical targets and therapeutic areas e.g. immunology, oncology. Includes both established therapeutics, e.g. <a href='/products/tamoxifen-citrate_0999'>tamoxifen</a> (Cat. No. 0999) and <a href='/products/taxol_1097'>paclitaxel</a> (Cat. No. 1097), as well as more recently approved drugs such as <a href='/products/darunavir_6710'>darunavir</a> (Cat. No. 6710) and <a href='/products/sorafenib_6814'>sorafenib</a> (Cat. No. 6814). Ideal for <em>in vitro</em> and <em>in vivo</em> drug repurposing/repositioning studies.</p><p><em>This library replaces the <a href='/products/tocriscreen-library-of-fda-approved-compounds_5932'>Tocriscreen Library of FDA-Approved Compounds</a> (Cat. No. 5932).</em></p><p><em>All Tocris products are for biomedical research use only. They are not intended for human or veterinary use.</em></p> </div> <div class="datasheet_section"> <h2 id="other-caveat-heading">Key Format and Product Details for Tocriscreen FDA-Approved Drugs Library</h2> <p><div style='float:left; width:50%'> <ul> <li>All compounds are equivalent to active components of FDA-approved drug formulations</li> <li>Full chemical and biological data available in Excell and SD file formats</li> <li>96-well racks with Matrix storage tubes & SepraSeal caps</li> </ul> </div> <div style='float:left; width:50%'> <ul> <li>Compounds arranged with a maximum of 80 per rack with 3 racks per library</li> <li>Pre-dissolved in 100 <span class='symbol'>μ</span>L 10 mM DMSO solutions</li> <li>Compounds produced to same high chemical standard as Tocris catalog </ul> </div> <div style='clear:left'></div> <img loading="lazy" src='https://resources.tocris.com/images/tocriscreen/tocriscreen-FDA-target-classes.jpg' style='max-width:100%; margin:20px 0 10px 0' alt='Target Classes Covered by the Tocriscreen FDA-approved Drugs Library'> <p>The Tocriscreen FDA-approved Drugs Library contains bioactive compounds covering a diverse range of therapeutic classifications, derived using the WHO Anatomical Therapeutic Chemical Classification System code (ATC code).</p></p> </div> <div id="ds_screenset_request" class="datasheet_section"> <h3>Request Compound List</h3> <p>To request a list of the compounds available in the Tocriscreen FDA-Approved Drugs Library please click the request tile below. Compound lists can be provided in Excel or SD format.</p> <p> <a class="btn btn-quinary bottom-margin" rel="nofollow" href="/support/screening-inquiry/7200" title="Request compound list for Tocriscreen FDA-Approved Drugs Library">Request compound list for Tocriscreen FDA-Approved Drugs Library</a> </p> </div> <div id="ds_technical_data" class="datasheet_section"> <h2>Technical Data for Tocriscreen FDA-Approved Drugs Library</h2> <table class="technical_data_table"> <tr> <td class="tdt_name"> Storage </td> <td class="tdt_data"> Store at -20°C </td> </tr> </table> <p class="small">The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.</p> <p class="small">Tocris products are intended for laboratory research use only, unless stated otherwise.</p> </div>  <div id="ds_datasheets" class="datasheet_section"> <h2>Product Datasheets for Tocriscreen FDA-Approved Drugs Library</h2> <div class="row"> <div class="col-sm-12 col-md-6"> Certificate of Analysis is currently unavailable on-line.<br>Please contact <a href="/support/contact-us">Customer Service</a> <div class="visible-xs-block visible-sm-block datasheet_section_element"></div> </div> <div class="col-sm-12 col-md-6"> <a href="https://documents.tocris.com/pdfs/tocris_msds/7200_sds.pdf?1732331324" class="datasheet_download" id="safety_datasheet" target="_blank" title="View Safety Datasheet for Tocriscreen FDA-Approved Drugs Library (Cat. No. 7200)">Safety Datasheet</a> </div> </div> </div> <div id="ds_reference_data" class="datasheet_section"> <h2>References for Tocriscreen FDA-Approved Drugs Library</h2> <p> <em>References are publications that support the biological activity of the product.</em> </p> <p> <span class="highlight">Li</span> <em>et al</em> (2015) <a href="https://www.ncbi.nlm.nih.gov/pubmed/26253201" rel="nofollow" target="_blank" title="View abstract"> Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. </a> Cell Stem Cell <strong><em>17</em></strong> 195 PMID: 26253201 <p> <span class="highlight">Edwards</span> <em>et al</em> (2014) <a href="https://www.ncbi.nlm.nih.gov/pubmed/24409953" rel="nofollow" target="_blank" title="View abstract"> The University of New Mexico Center for Molecular Discovery. </a> Comb.Chem.High Throughput Screen. <strong><em>17</em></strong> 256 PMID: 24409953 <hr/> <p>If you know of a relevant reference for Tocriscreen FDA-Approved Drugs Library, <a href="/suggest-reference/catnum/7200" rel="nofollow">please let us know</a>.</p> </div> <div class="rel_by_target datasheet_section"> <h2>View Related Products by Target</h2> <ul class="ds_rel_targets"> <li><a class="btn btn-quinary bottom-margin" href="/product-type/tocriscreen-compound-libraries" title="Browse all products for Tocriscreen™ Compound Libraries">Tocriscreen™ Compound Libraries</a></li> </ul> </div> <div class="product_keywords datasheet_section"> <p>Keywords: Tocriscreen FDA-Approved Drugs Library, Tocriscreen FDA-Approved Drugs Library supplier, biologically, active, pre-dissolved, DMSO, 10mM, solutions, Tocriscreen, Compound, Collections, Screening, Library, Libraries, HTS, HCS, high, throughput, content, FDA-approved, drug, library, repurposing, target, validation, repositioning, 7200, Tocris Bioscience</p> </div> </div> </div><div class="tab_content tab_2" data-tab="2"><a id="product-citations"></a><div id="citations"> <div class="datasheet_section_element"> <h3><span class="citations">7 Citations for Tocriscreen FDA-Approved Drugs Library</span></h3> <p> <em> Citations are publications that use Tocris products. Selected citations for Tocriscreen FDA-Approved Drugs Library include: </em> </p> <p> <span class="highlight">Shin</span> <em>et al</em> (2018) <a href="https://www.ncbi.nlm.nih.gov/pubmed/29795047" rel="nofollow" target="_blank" title="View abstract"> Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication <em>In Vitro</em>.</a> Viruses <strong><em>10</em></strong> E283 PMID: 29795047 </p> <p> <span class="highlight">Edmister</span> <em>et al</em> (2022) <a href="https://www.ncbi.nlm.nih.gov/pubmed/35449173" rel="nofollow" target="_blank" title="View abstract"> Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles.</a> Sci.Rep. <strong><em>12</em></strong> 6120 PMID: 35449173 </p> <p> <span class="highlight">Chaffey</span> <em>et al</em> (2024) <a href="https://www.ncbi.nlm.nih.gov/pubmed/38417608" rel="nofollow" target="_blank" title="View abstract"> Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages.</a> Eur.J.Pharmacol. <strong><em>969</em></strong> 176437 PMID: 38417608 </p> <p> <span class="highlight">Gore</span> <em>et al</em> (2023) <a href="https://www.ncbi.nlm.nih.gov/pubmed/36823315" rel="nofollow" target="_blank" title="View abstract"> Zebrafish Larvae Position Tracker (Z-LaP Tracker): a high-throughput deep-learning behavioral approach for the identification of calcineurin pathway-modulating drugs using zebrafish larvae.</a> Sci.Rep. <strong><em>13</em></strong> 3174 PMID: 36823315 </p> <div id="ds_extra_cits"> <p> <span class="highlight">Kim</span> <em>et al</em> (2023) <a href="https://www.ncbi.nlm.nih.gov/pubmed/37097659" rel="nofollow" target="_blank" title="View abstract"> Nebivolol sensitizes BT-474 breast cancer cells to FGFR inhibitors.</a> Anticancer Res. <strong><em>43</em></strong> 1973 PMID: 37097659 </p> <p> <span class="highlight">Gull</span> <em>et al</em> (2023) <a href="https://www.ncbi.nlm.nih.gov/pubmed/36180216" rel="nofollow" target="_blank" title="View abstract"> Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery.</a> Cold Spring Harb.Protoc. PMID: 36180216 </p> <p> <span class="highlight">Mehyar</span> <em>et al</em> (2020) <a href="https://www.ncbi.nlm.nih.gov/pubmed/33401979" rel="nofollow" target="_blank" title="View abstract"> Using <em>in silico</em> modelling and FRET-based assays in the discovery of novel FDA-approved drugs as inhibitors of MERS-CoV helicase.</a> SAR QSAR Environ Res <strong><em>6</em></strong> 1 PMID: 33401979 </p> </div> <div class="clearfix"> <button class="btn btn-quinary ds_extra_cits pull-right toggle_cits_down" id="toggle_cits"></button> </div> <hr/> <p> Do you know of a great paper that uses Tocriscreen FDA-Approved Drugs Library from Tocris? <a href="/suggest-citation/catnum/7200" rel="nofollow">Please let us know</a>. </p> </div> </div> </div><div class="tab_content tab_3" data-tab="3"><a id="product-reviews"></a><h3>Reviews for Tocriscreen FDA-Approved Drugs Library</h3> <div class="row datasheet_section"> <div class="col-md-6"> <p>There are currently no reviews for this product. Be the first to <a href="/reviews/7200" rel="nofollow">review Tocriscreen FDA-Approved Drugs Library</a> and earn rewards! </p> </div> <div class="col-md-6"> <div class="well"> <h4>Have you used Tocriscreen FDA-Approved Drugs Library?</h4> <h5><strong>Submit a review and receive an Amazon gift card.</strong></h5> <div class="review_reward_txt"> <p>$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image</p> <p>$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image</p> <p>$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image</p> </div> <a class="btn btn-quinary" href="/reviews/7200" rel="nofollow">Submit a Review</a> </div> </div> </div> </div><div class="tab_content tab_4" data-tab="4"><a id="product-literature"></a><div id="literature"> <h3>Literature in this Area</h3> <p>Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!</p> <p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p> <hr/> <div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/product-guides/fullsize/697383.jpg?v=2" data-toggle="lightbox" data-title="Tocriscreen Compound Libraries " data-footer="<a href='/literature/literature-request/697383' rel='nofollow' title='Request copy of the Tocriscreen Compound Libraries'>Request copy</a> or <a href='/literature/literature-request/p697383' rel='nofollow' title='Request PDF of the Tocriscreen Compound Libraries'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/697383.jpg?v=2" alt="Tocriscreen Compound Libraries " class="img-fluid"></a></div> <h4>Tocriscreen Compound Libraries </h4> <p>This brochure gives an overview of the unique Tocriscreen<sup>TM</sup> bioactive compound library range, including</p> <ul class='bullet_list'> <li>Tocriscreen 2.0 Compound Library</li> <li>Focused Tocriscreen Libraries</li> <li>Tocriscreen FDA-approved Drug Library</li> <li>Tocriscreen PRO Custom Service</li> </ul> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/697383" rel="nofollow" title="Request copy of the Tocriscreen Compound Libraries ">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p697383" rel="nofollow" title="Request PDF of the Tocriscreen Compound Libraries ">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/product-guides" title="View all Product Guides & Listings">View all Product Guides & Listings</a></li> </ul> </div></div></div> </div></div></div><div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="distributor_region"></div>  <div class="widget"> <div class="widget_title">Literature in this Area</div> <div class="widget_content carousel slide" id="ds_literature_scroller" data-ride="carousel" data-interval="8000">  <div class="carousel-inner"><div class="item active"><div class="highlight">Tocriscreen Compound Libraries</div> <a href="/literature/product-guides/tocriscreen-compound-libraries"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/697383.jpg?v=2" alt="Tocriscreen Compound Libraries "></a><p class="small">Learn more about Tocriscreen bioactive compound libraries, and our Tocriscreen PRO custom compound library service.</p><a class="btn btn-quinary" href="/literature/literature-request/697383" rel="nofollow" title="Request copy of the Tocriscreen Compound Libraries ">Request copy</a><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p697383" rel="nofollow" title="Request PDF of the Tocriscreen Compound Libraries ">Request PDF<div class="lit_request_pdf"></div></a></div></div>  </div> </div> <div class="widget"> <div class="sidebar-box-wrapper"> <a href="/reviews/7200" title="Submit a Product Review" rel="nofollow"><img loading="lazy" alt="Submit a Product Review" class="fp_four_box_image" src="//resources.tocris.com/images/homepage/featured/reviews.jpg"></a> <article class="box-content"> <h3> <a href="/reviews/7200" title="Submit a Product Review" rel="nofollow">Submit a Review & Earn an Amazon Gift Card</a> </h3> <p>You can now submit reviews for your favorite Tocris products. 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