Nature Reviews Bioengineering

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Here, we would like to offer some insights on how to craft a comprehensive and authoritative assessment of a field.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Editorial</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-11" itemprop="datePublished">11 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs44222-024-00259-1/MediaObjects/44222_2024_259_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00259-1/MediaObjects/44222_2024_259_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00259-1/MediaObjects/44222_2024_259_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44222-024-00259-1" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Engineering circular RNA medicines</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Compared to linear mRNA, circular RNAs offer greater stability during storage and delivery, along with more sustained effects due to their circular structure. This Review provides an overview of circRNA-based therapeutics, highlighting key engineering principles, associated challenges and strategies to address such challenges.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiaofei Cao</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Zhengyi Cai</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Fangqing Zhao</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-20" itemprop="datePublished">20 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs44222-024-00255-5/MediaObjects/44222_2024_255_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00255-5/MediaObjects/44222_2024_255_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00255-5/MediaObjects/44222_2024_255_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44222-024-00255-5" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">The physico-chemical landscape of extracellular vesicles</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Extracellular vesicles are being explored for various biomedical applications, but face challenges with regard to isolation, characterization and manufacturing. This Review delineates the physico-chemical landscape of extracellular vesicles to identify the distinct challenges associated with the manufacturing and isolation of extracellular vesicles from biofluids and suggests opportunities to address them.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Mauro Manno</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Antonella Bongiovanni</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Paolo Arosio</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-12" itemprop="datePublished">12 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs44222-024-00257-3/MediaObjects/44222_2024_257_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00257-3/MediaObjects/44222_2024_257_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00257-3/MediaObjects/44222_2024_257_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44222-024-00257-3" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Imaging-guided precision hyperthermia with magnetic nanoparticles</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>This Review details the use of multifunctional magnetic nanoparticles in advanced magnetic imaging modalities and therapeutic hyperthermia. 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</article> </div></li> </ul> </div> <div class="app-latest-issue-row__side"> <div class="app-latest-issue-row__image"> <picture> <source type="image/webp" srcset="https://media.springernature.com/w440/springer-static/cover-hires/journal/44222/2/11?as=webp&q=95"> <img src="https://media.springernature.com/w440/springer-static/cover-hires/journal/44222/2/11?q=95" alt="Volume 2 Issue 11" itemprop="image"> </picture> </div> <div class="app-latest-issue-row__buttons app-latest-issue-row--by-3"> <div class="app-latest-issue-row__button"> <a href="/natrevbioeng/current-issue" class="u-button u-button--full-width" data-track="click" data-track-action="view current issue" data-track-label="button">Contents</a> </div> <div class="app-latest-issue-row__button"> <a href="/natrevbioeng/volumes/2" class="u-button u-button--full-width" data-track="click" data-track-action="click view all issues">View all issues</a> </div> <div class="app-latest-issue-row__button"><a href="/natrevbioeng/subscribe" 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https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-8ec09bd3a6d8d73158eae7841cdc2680.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img data-test="image-0" src="https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-8ec09bd3a6d8d73158eae7841cdc2680.jpg" alt="NRBioeng logo" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline" data-test="announcement-title-0"> <a href="https://bit.ly/3ibWMbi" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="click on homepage featured announcement" data-track-label="announcement 0"> Virtual lab visits </a> </h3> <div class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description" data-test="description-0"> <p>Interested in meeting our editors in a virtual 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Click the link above to find out more.</p> </div> </div> </div> </article> </li> <li class="app-announcement-list-row__item"> <article class="c-card c-card--flush u-pl-0 u-justify-content-space-between"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-077c59889000676b0ad354531f0300b2.jpg?as=webp 160w, https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-077c59889000676b0ad354531f0300b2.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img data-test="image-1" src="https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-077c59889000676b0ad354531f0300b2.jpg" alt="Slice of brain with circuits" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline" data-test="announcement-title-1"> <a href="https://www.youtube.com/watch?v=C0X4N_ihJAc" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="click on homepage featured announcement" data-track-label="announcement 1"> Clinical trials of brain-computer interfaces </a> </h3> <div class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description" data-test="description-1"> <p>Watch our webcast discussing the state of clinical trials of implantable brain-computer interfaces, with field leader Jose Contreras-Vidal and Mariska Vansteensel, an expert in conducting clinical trials of implanted brain machine interfaces.</p> </div> </div> </div> </article> </li> <li class="app-announcement-list-row__item"> <article class="c-card c-card--flush u-pl-0 u-justify-content-space-between"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-08d50828566b825c19cd6a5ef9213885.jpg?as=webp 160w, https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-08d50828566b825c19cd6a5ef9213885.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img data-test="image-2" src="https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/21404/announcement-image-08d50828566b825c19cd6a5ef9213885.jpg" alt="Person with wireless implants walking up stairs" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline" data-test="announcement-title-2"> <a href="https://www.nature.com/collections/gahbighdbh" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="click on homepage featured announcement" data-track-label="announcement 2"> Clinical translation of neurotechnologies </a> </h3> <div class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description" data-test="description-2"> <p>Neurotechnologies, such as brain-machine interfaces, have the potential to restore functions in individuals with neurological disorders, but face challenges in development, ethics and implementation. 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This Review discusses different approaches towards nanopore-based protein sequencing, outlining methods to distinguish amino acids, control protein translocation and detect post-translational modifications.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Justas Ritmejeris</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiuqi Chen</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Cees Dekker</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-21" itemprop="datePublished">21 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs44222-024-00259-1/MediaObjects/44222_2024_259_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00259-1/MediaObjects/44222_2024_259_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00259-1/MediaObjects/44222_2024_259_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44222-024-00259-1" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Engineering circular RNA medicines</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Compared to linear mRNA, circular RNAs offer greater stability during storage and delivery, along with more sustained effects due to their circular structure. 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This Review delineates the physico-chemical landscape of extracellular vesicles to identify the distinct challenges associated with the manufacturing and isolation of extracellular vesicles from biofluids and suggests opportunities to address them.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Mauro Manno</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Antonella Bongiovanni</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Paolo Arosio</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-12" itemprop="datePublished">12 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44222-024-00256-4" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">How to write an excellent Review article</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Review articles are our bread and butter. Here, we would like to offer some insights on how to craft a comprehensive and authoritative assessment of a field.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Editorial</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-11" itemprop="datePublished">11 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs44222-024-00257-3/MediaObjects/44222_2024_257_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00257-3/MediaObjects/44222_2024_257_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs44222-024-00257-3/MediaObjects/44222_2024_257_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44222-024-00257-3" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Imaging-guided precision hyperthermia with magnetic nanoparticles</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>This Review details the use of multifunctional magnetic nanoparticles in advanced magnetic imaging modalities and therapeutic hyperthermia. The potential of magnetic nanoparticles for imaging-guided precision heating of tumours and the need for integrated magnetic imaging and heating platforms are highlighted.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Ali Shakeri-Zadeh</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Jeff W. M. 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