{"title":"Association between ADHD Medication, Cannabis, and Nicotine Use, Mental Distress, and Other Psychoactive Substances","authors":"Nicole Scott, Emily Dwyer, Cara Patrissy, Samantha Bonventre, Lina Begdache","volume":205,"journal":"International Journal of Psychological and Behavioral Sciences","pagesStart":62,"pagesEnd":72,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/10013487","abstract":"<p>Across North America, the use and abuse of Attention Deficit Hyperactivity Disorder (ADHD) medication, cannabis, nicotine, and other psychoactive substances across college campuses have become an increasingly prevalent problem. Students frequently use these substances to aid their studying or deal with their mental health issues. However, it is still unknown what psychoactive substances are likely to be abused when college students illicitly use ADHD medication. In addition, it is not clear which psychoactive substance is associated with mental distress. Thus, the purpose of this study is to fill these gaps by assessing the use of different psychoactive substances when illicit ADHD medication is used; and how this association relates to mental stress. A total of 702 undergraduate students from different college campuses in the US completed an anonymous survey distributed online. Data were self-reported on demographics, the use of ADHD medications, cannabis, nicotine, other psychoactive drugs, and mental distress, and feelings and opinions on the use of illicit study drugs were all included in the survey. Mental distress was assessed using the Kessler Psychological Distress 6 Scale. Data were analyzed in SPSS, Version 25.0, using Pearson\u2019s Correlation Coefficient. Our results show use of ADHD medication, cannabis use (non-frequent and very frequent), and nicotine use (non-frequent and very frequent); there were both statistically significant positive and negative correlations to specific psychoactive substances and their corresponding frequencies. Along the same lines, ADHD medication, cannabis use (non-frequent and very frequent), and nicotine use (non-frequent and very frequent) had statistically significant positive and negative correlations to specific mental distress experiences. As these findings are combined, a vicious loop can initiate a cycle where individuals who abuse psychoactive substances may or may not be inclined to use other psychoactive substances. This may later inhibit brain functions in those main areas of the brain stem, amygdala, and prefrontal cortex where this vicious cycle may or may not impact their mental distress. Addressing the impact of study drug abuse and its potential to be associated with further substance abuse may provide an educational framework and support proactive approaches to promote awareness among college students.<\/p>","references":"[1]\tBurgard, D. (2013, April 15). Potential Trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: Wastewater analysis of amphetamine and ritalinic acid. Science Direct. Retrieved December 6, 2022, from https:\/\/www-sciencedirect-com.proxy.binghamton.edu\/science\/article\/pii\/S0048969713001836 \r\n[2]\tSussman, S., Pentz, M. A., Spruijt-Metz, D., & Miller, T. (2006). Misuse of \"study drugs:\" prevalence, consequences, and implications for policy. Substance abuse treatment, prevention, and policy, 1, 15. https:\/\/doi.org\/10.1186\/1747-597X-1-15 \r\n[3]\tWeyandt, L. (2016, October). Prescription Stimulant Medication Misuse: Where Are We and Where Do We Go from Here? Department of Health and Human Services, Exp Clin Psychopharmacol. Retrieved December 6, 2022, from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5113141\/pdf\/nihms818042.pdf \r\n[4]\tFaraone SV. The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit\/hyperactivity disorder and other psychiatric comorbidities. Neurosci Biobehav Rev. 2018 Apr;87:255-270. doi: 10.1016\/j.neubiorev.2018.02.001. Epub 2018 Feb 8. PMID: 29428394; PMCID: PMC8063758.\r\n[5]\tWeyandt LL, White TL, Gudmundsdottir BG, Nitenson AZ, Rathkey ES, De Leon KA, Bjorn SA. Neurocognitive, Autonomic, and Mood Effects of Adderall: A Pilot Study of Healthy College Students. Pharmacy. 2018; 6(3):58. https:\/\/doi.org\/10.3390\/pharmacy6030058 \r\n[6]\tRabiner, D. L., & Anastopoulos, A. D. (2009). The misuse and diversion of prescribed ADHD medications by college students. Journal of Attention Disorders, 13(2), 144\u2013153. https:\/\/doi.org\/10.1177\/1087054708320414 \r\n[7]\tNational Institutes of Health. (2021, September 8). Marijuana use at historic high among college-aged adults in 2020. National Institute on Drug Abuse. Retrieved December 6, 2022, from https:\/\/www.nih.gov\/news-events\/news-releases\/marijuana-use-historic-high-among-college-aged-adults-2020 \r\n[8]\tNational Center for Injury Prevention and Control. (2021, October). Marijuana: What we know - centers for disease control and prevention. Center for Disease Control and Prevention-National Center for Injury Prevention and Control. Retrieved March 19, 2023, from https:\/\/www.cdc.gov\/marijuana\/factsheets\/pdf\/MarijuanaFactSheets-WhatWeKnow-508compliant.pdf \r\n[9]\tSheikh, NK, Dua A. (2022, May 2). Cannabinoids. National Library of Medicine. Retrieved December 6, 2022, from https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK556062\/#:~:text=Go%20to %3A,Mechanism%20of%20Action,and%20playing%20a%20homeostatic%20role \r\n[10]\tBeck, K. H., Caldeira, K. M., Vincent, K. B., O'Grady, K. E., Wish, E. D., & Arria, A. M. (2009). The social context of cannabis use: Relationship to cannabis use disorders and depressive symptoms among college students. Addictive Behaviors, 34(9), 764\u2013768. https:\/\/doi.org\/10.1016\/j.addbeh.2009.05.001 \r\n[11]\tVan Ours, J. C., & Williams, J. (2011). Cannabis use and mental health problems. Journal of Applied Econometrics, 26(7), 1137\u20131156. https:\/\/doi.org\/ https:\/\/doi.org\/10.1002\/jae.1182 \r\n[12]\tSharpe, L., Sinclair, J., Kramer, A., de Manincor, M., & Sarris, J. (2020). Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties. Journal of translational medicine, 18(1), 374. https:\/\/doi.org\/10.1186\/s12967-020-02518-2 \r\n[13]\tArria, A. M., Caldeira, K. M., Bugbee, B. A., Vincent, K. B., & O'Grady, K. E. (2015). The academic consequences of marijuana use during college. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 29(3), 564\u2013575. https:\/\/doi.org\/10.1037\/adb0000108\r\n[14]\tCenter for Disease Controls and Prevention. (2008, November 14). Smoking-attributable mortality, years of potential life lost, and productivity losses --- United States, 2000--2004. Centers for Disease Control and Prevention. Retrieved December 4, 2022, from https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5745a3.html \r\n[15]\tOffice of the Surgeon General (US), & Office on Smoking and Health (US). (2004). The Health Consequences of Smoking: A Report of the Surgeon General. Centers for Disease Control and Prevention (US).\r\n[16]\tBenowitz, N. L. (2010, June 17). Nicotine addiction. New England Journal of Medicine. Retrieved December 4, 2022, from https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmra0809890?casa_token= 2rLY--7vesIAAAAA%3Avy7HpSsx0ea1KBs4Xh2i5HApEd- K_Gov4O4sRoFO8AdRE0zPpkiZwDQtDEfwICLo_B8JXeSwGXLbmA \r\n[17]\tFaure, P., Tolu, S., Valverde, S., & Naud\u00e9, J. (2014). Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity. Neuroscience, 282, 86\u2013100. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.05.040\r\n[18]\tR. DiFranza, J. (2015). A 2015 update on the natural history and diagnosis of nicotine addiction. http:\/\/www.eurekaselect.com. Retrieved December 4, 2022, from https:\/\/dx.doi.org\/10.2174\/1573396311666150501002703\r\n[19]\tYuan, M., & Cross, S. (2015, May 27). Nicotine and the adolescent brain - yuan - 2015 - the journal of ... The Journal of Physiology. Retrieved December 4, 2022, from https:\/\/doi.org\/10.1113\/JP270492 \r\n[20]\tKasza KA, Ambrose BK, Conway KP, Borek N, Taylor K, Goniewicz ML, Cummings KM, Sharma E, Pearson JL, Green VR, Kaufman AR, Bansal-Travers M, Travers MJ, Kwan J, Tworek C, Cheng YC, Yang L, Pharris-Ciurej N, van Bemmel DM, Backinger CL, Compton WM, Hyland AJ. Tobacco-Product Use by Adults and Youths in the United States in 2013 and 2014. N Engl J Med. 2017 Jan 26;376(4):342-353. doi: 10.1056\/NEJMsa1607538. Erratum in: N Engl J Med. 2018 Feb 1;378(5):492. PMID: 28121512; PMCID: PMC5317035.\r\n[21]\tLatimer LA, Batanova M, Loukas A. Prevalence and harm perceptions of various tobacco products among college students. Nicotine Tob Res. 2014 May;16(5):519-26. doi: 10.1093\/ntr\/ntt174. Epub 2013 Nov 9. PMID: 24212764.\r\n[22]\tWorld Health Organization. (2005, January). Promoting mental health: Concepts, emerging evidence, practice2005. World Health Organization. Retrieved December 6, 2022, from https:\/\/www.who.int\/publications\/i\/item\/9241562943\r\n[23]\tSchroeder S. A. (2016). Smoking cessation should be an integral part of serious mental illness treatment. World psychiatry: Official Journal of the World Psychiatric Association (WPA), 15(2), 175\u2013176. https:\/\/doi.org\/10.1002\/wps.20332\r\n[24]\tLouisa Degenhardt, BA (Hons), and Wayne Hall, PhD, The relationship between tobacco use, substance-use disorders and mental health: results from the National Survey of Mental Health and Well-being, Nicotine & Tobacco Research, Volume 3, Issue 3, August 2001, Pages 225\u2013234, https:\/\/doi.org\/10.1080\/14622200110050457\r\n[25]\tNegash, A., Khan, M. A., Medhin, G., Wondimagegn, D., & Araya, M. (2020). Mental distress, perceived need, and barriers to receive professional mental health care among university students in Ethiopia. BMC psychiatry, 20(1), 187. https:\/\/doi.org\/10.1186\/s12888-020-02602-3\r\n[26]\tHan KM, Ham BJ. How Inflammation Affects the Brain in Depression: A Review of Functional and Structural MRI Studies. J Clin Neurol. 2021 Oct;17(4):503-515. doi: 10.3988\/jcn.2021.17.4.503. PMID: 34595858; PMCID: PMC8490908.\r\n[27]\tPedrelli, P., Nyer, M., Yeung, A., Zulauf, C., & Wilens, T. (2015). College Students: Mental Health Problems and Treatment Considerations. Academic psychiatry: the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, 39(5), 503\u2013511. https:\/\/doi.org\/10.1007\/s40596-014-0205-9\r\n[28]\tJenkins BW, Khokhar JY. Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models. Front Psychiatry. 2021 Feb 5;12:597725. doi: 10.3389\/fpsyt.2021.597725. PMID: 33613338; PMCID: PMC7892618.\r\n[29]\tMart\u00ednez-V\u00e9lez NA, Tiburcio M, Natera Rey G, Villatoro Vel\u00e1zquez JA, Arroyo-Belmonte M, S\u00e1nchez-Hern\u00e1ndez GY, Fern\u00e1ndez-Torres M. Psychoactive Substance Use and Its Relationship to Stress, Emotional State, Depressive Symptomatology, and Perceived Threat During the COVID-19 Pandemic in Mexico. Front Public Health. 2021 Aug 23;9:709410. doi: 10.3389\/fpubh.2021.709410. PMID: 34497792; PMCID: PMC8419305.\r\n[30]\tDuPaul, G. J., Weyandt, L. L., O\u2019Dell, S. M., & Varejao, M. (2009). College Students With ADHD: Current Status and Future Directions. Journal of Attention Disorders, 13(3), 234\u2013250. https:\/\/doi.org\/10.1177\/1087054709340650\r\n[31]\tBoak, A., Elton-Marshall, T., Mann, R. E. & Hamilton, H. A. (2020). Drug use among Ontario students, 1977-2019: Detailed findings from the Ontario Student Use and Health Survey (OSDUHS) Toronto, ON: Center for Addiction and Mental Health\r\n[32]\tProchaska, J. J., Sung, H. Y., Max, W., Shi, Y., & Ong, M. (2012). Validity study of the K6 Fscale as a measure of moderate mental distress based on mental health treatment need and utilization. International journal of methods in psychiatric research, 21(2), 88\u201397. https:\/\/doi.org\/10.1002\/mpr.1349\r\n[33]\tCrum AJ, Salovey P, Achor S. Rethinking stress: the role of mindsets in determining the stress response. J Pers Soc Psychol. 2013 Apr; 104(4):716-33. doi: 10.1037\/a0031201. Epub 2013 Feb 25. PMID: 23437923.\r\n[34]\tCohen, S., Kamarck, T., & Mermelstein, R. (1983). Perceived Stress Scale, Database record. APA PsycTests. https:\/\/doi.org\/10.1037\/t02889-000\r\n[35]\tSmith BW, Dalen J, Wiggins K, Tooley E, Christopher P, Bernard J. The brief resilience scale: assessing the ability to bounce back. Int J Behav Med. 2008;15(3):194-200. doi: 10.1080\/10705500802222972. PMID: 18696313. \r\n[36]\tT. Kuther, The Role of GPA in Graduate School Admissions, ThoughtCo. (2018). https:\/\/www.thoughtco.com\/gpa-role-in-graduate-school-admissions-1685863.\r\n[37]\tRolland, A. D., & Smith, P. J. (2016, November 30). Aided by Adderall: Illicit use of ADHD medications by college students. Journal of the National Collegiate Honors Council. Retrieved December 6, 2022, from https:\/\/eric.ed.gov\/?id=EJ1222138 \r\n[38]\tS\u00f6r\u00f6s, P., Hoxhaj, E., Borel, P., Sadohara, C., Feige, B., Matthies, S., M\u00fcller, H. H. O., Bachmann, K., Schulze, M., & Philipsen, A. (2019). Hyperactivity\/restlessness is associated with increased functional connectivity in adults with ADHD: a dimensional analysis of resting state fMRI. BMC psychiatry, 19(1), 43. https:\/\/doi.org\/10.1186\/s12888-019-2031-9 \r\n[39]\tMoonzwe, L. S., Schensul, J. J., & Kostick, K. M. (2011). The role of MDMA (Ecstasy) in coping with negative life situations among urban young adults. Journal of psychoactive drugs, 43(3), 199\u2013210. https:\/\/doi.org\/10.1080\/02791072.2011.605671\r\n[40]\tSchoenfelder, E. N., Faraone, S. V., & Kollins, S. H. (2014). Stimulant treatment of ADHD and cigarette smoking: a meta-analysis. Pediatrics, 133(6), 1070\u20131080. https:\/\/doi.org\/10.1542\/peds.2014-0179\r\n[41]\tBegdache, L., Kianmehr, H., Sabounchi, N., Marszalek, A., & Dolma, N. (2021). Common and differential associations between levels of alcohol drinking, gender-specific neuro behaviors and mental distress in college students. Trends in Neuroscience and Education, 19, 100129. https:\/\/doi.org\/10.1016\/j.tine.2020.100129\r\n[42]\tHardey, S., Thomas, S., Stein, S., Kelley, R., & Ackermann, K. (2022, September 9). Addiction as a coping mechanism and healthy alternatives. American Addiction Centers. Retrieved December 7, 2022, from https:\/\/americanaddictioncenters.org\/sobriety-guide\/coping-mechanism \r\n[43]\tSchwarz, A. (2013). Drowned in a Stream of Prescriptions. The New York Times. Retrieved December 6, 2022 from https:\/\/www.nytimes.com\/2013\/02\/03\/us\/concerns-about-adhd-practices- and-amphetamine-addiction.html#:~:text=QUESTIONNAIRE %20Richard%20Fee%20first%20received,order%20to%20get%20a%20prescription.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 205, 2024"}