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class="h pbm"> <h1 class="ph"> 自然疗法可以逆转阿尔茨海默病的症状 <a href="https://blog.sciencenet.cn/blog.php?mod=recommend"><img src="./static/image/blog/recommendico.gif" width="22px" height="22px" /><font style="font-size:14px; color:#930;" face="宋体">精选</font></a> </h1> <p class="xg2"> <span class="xg1">已有 2799 次阅读</span> <span class="xg1">2024-11-22 20:42</span> <span class="pipe">|</span><span class="xg1">个人分类:<a href="https://blog.sciencenet.cn/home.php?mod=space&uid=212210&do=blog&classid=154035&view=me">药物动态</a></span><span class="pipe">|</span><span class="xg1">系统分类:<a href="https://blog.sciencenet.cn/home.php?mod=space&do=blog&view=all&uid=212210&catid=2">海外观察</a></span> </p> </div> <div id="blog_article" class="d cl" ><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">自然疗法可以逆转阿尔茨海默病的症状</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">诸平</span></p><p style="text-align:center"><a href="https://scitechdaily.com/images/Neuroscience-Brain-Mapping-Confusion-Dementia.jpg" target="_blank" target="_blank"><img src="http://image.sciencenet.cn/home/202411/22/203636p9qfq2573s3wrf7w.jpg" title="" alt="Neuroscience-Brain-Mapping-Confusion-Dementia.jpg" style="width: 464px; height: 429px;" height="429" width="464"/></a></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;">Fig. 1 </span><a href="https://scitechdaily.com/natural-remedy-reverses-alzheimers-symptoms-in-new-study/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Researchers found that Ziziphus jujuba seeds improve cognitive and motor functions in mice with neurodegenerative diseases, showing promise for future dementia prevention products.</span></a></p><p style="text-align:center"><a href="https://scitechdaily.com/images/Jujube-Dried-Seeds-scaled.jpg" target="_blank" target="_blank"><img src="http://image.sciencenet.cn/home/202411/22/203716pjf3e0za2jl9rqf0.jpg" title="" alt="Jujube-Dried-Seeds-scaled.jpg" style="width: 499px; height: 427px;" height="427" width="499"/></a></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;">Fig. 2 </span><a href="https://scitechdaily.com/natural-remedy-reverses-alzheimers-symptoms-in-new-study/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">These dried seeds of a type of jujube called Ziziphus jujuba Miller var. spinosa hold potential in preventing dementia. Credit: Osaka Metropolitan University</span></a></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">据日本大阪公立大学</span><span style="font-size: 18px; font-family: times new roman;">（</span><a href="https://www.omu.ac.jp/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Osaka Metropolitan University</span></a><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">）</span>2024<span style="font-size: 18px; font-family: 宋体;">年</span>11<span style="font-size: 18px; font-family: 宋体;">月</span>20<span style="font-size: 18px; font-family: 宋体;">日提供的消息，在新的研究中，自然疗法可以逆转阿尔茨海默病的症状（</span></span><a href="https://scitechdaily.com/natural-remedy-reverses-alzheimers-symptoms-in-new-study/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Natural Remedy Reverses Alzheimer’s Symptoms in New Study</span></a><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">）。原文详见：</span>Tomohiro Umeda, Ayumi Sakai, Rumi Uekado, Keiko Shigemori, Ryota Nakajima, Kei Yamana, Takami Tomiyama. Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice. </span><a href="https://doi.org/10.7554/eLife.100737.1" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">eLife</span></a><span style="font-size: 18px; font-family: times new roman;">, 13 September 2024. </span><a href="https://doi.org/10.7554/eLife.100737.1" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">DOI: 10.7554/eLife.100737.1</span></a><span style="font-size: 18px; font-family: times new roman;">. </span><a href="https://doi.org/10.7554/eLife.100737.1" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">https://doi.org/10.7554/eLife.100737.1</span></a></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><strong><span style="font-size: 18px; font-family: 宋体;">用提取物和粉末处理的模型小鼠表现出认知和运动功能的恢复（</span></strong><strong><span style="font-size: 18px; font-family: 宋体;"></span></strong><strong><a href="https://scitechdaily.com/natural-remedy-reverses-alzheimers-symptoms-in-new-study/" target="_blank" target="_blank">Model mice treated with extracts and powders exhibit restored cognitive and motor functions</a></strong><strong><span style="font-size: 18px; font-family: 宋体;">）</span></strong></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">开发一种突破性的痴呆症药物的努力正在受到关注，但传统药物可能为预防保健提供有价值的见解。</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">大阪公立大学医学研究生院</span><span style="font-size: 18px; font-family: times new roman;">（</span><a href="https://scitechdaily.com/tag/osaka-metropolitan-university/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Osaka Metropolitan University’s Graduate School of Medicine</span></a><span style="font-size: 18px; font-family: times new roman;">）<span style="font-size: 18px; font-family: 宋体,SimSun;">特聘教授</span></span><a href="https://www.med.osaka-cu.ac.jp/Neurosci/member.html" style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: 宋体,SimSun;">富山贵美</span></a><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">（</span>Takami Tomiyama<span style="font-size: 18px; font-family: 宋体;">）领导的研究小组发现，给模型小鼠服用一种名为酸枣（</span></span><a href="https://www.iplant.cn/frps2019/frps/Ziziphus%20jujuba%20var.%20spinosa" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Ziziphus jujuba Miller vars . spinosa</span></a><span style="font-size: 18px; font-family: times new roman;">）<span style="font-size: 18px; font-family: 宋体,SimSun;">的干种子（酸枣仁），有望恢复其认知和运动功能。</span></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><strong><span style="font-size: 18px; font-family: 宋体;">模型小鼠研究的有希望的结果（</span></strong><strong><span style="font-size: 18px; font-family: 宋体;"></span></strong><strong><a href="https://scitechdaily.com/natural-remedy-reverses-alzheimers-symptoms-in-new-study/" target="_blank" target="_blank">Promising Results from Model Mice Studies</a></strong><strong><span style="font-size: 18px; font-family: 宋体;">）</span></strong></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">研究小组对患有阿尔茨海默病（</span>Alzheimer’s disease<span style="font-size: 18px; font-family: 宋体;">）、额颞叶痴呆（</span>frontotemporal dementia<span style="font-size: 18px; font-family: 宋体;">）、帕金森氏病（</span>Parkinson’s disease<span style="font-size: 18px; font-family: 宋体;">）、路易体痴呆（</span>dementia with Lewy bodies<span style="font-size: 18px; font-family: 宋体;">）等疾病的模型小鼠给予酸枣仁（</span>Zizyphi spinosi semen<span style="font-size: 18px; font-family: 宋体;">）热水提取物进行实验，结果发现，小鼠的认知功能和运动功能得到了恢复。</span></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">此外，当将种子碾碎成粉末并给模型小鼠服用时，研究小组发现，模型小鼠的认知功能恢复到高于对照组小鼠的水平。另外，这些粉末明显抑制了老年小鼠的细胞衰老，并将它们的认知功能提高到与年轻小鼠相似的水平。</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">此前，研究小组成员分别报告说，在使用夏威夷草药</span>Mamaki<span style="font-size: 18px; font-family: 宋体;">（</span></span><a href="https://pubmed.ncbi.nlm.nih.gov/37783918/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Hawaiian herb Mamaki</span></a><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">）和中草药石菖蒲（</span><em>Acorus gramineus</em><span style="font-size: 18px; font-family: 宋体;">）后，模型小鼠的痴呆症病理得到改善，认知和运动功能得到恢复。</span></span></p><p style="line-height: 2em;"><a href="https://www.med.osaka-cu.ac.jp/Neurosci/member.html" style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: 宋体,SimSun;">富山贵美</span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">教授表示：“我们的研究结果有望开发出中老年人可以自行服用的痴呆症预防产品。”</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">富山贵美是名流制药株式会社</span><span style="font-size: 18px; font-family: times new roman;">（</span><a href="https://cerebro-p.com/company/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">セレブロファーマ<span style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;">株式会社</span></span></a><span style="font-size: 18px; font-family: times new roman;"> / </span><a href="https://cerebro-p.com/company/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Cerebro Pharma Inc.</span></a><span style="font-size: 18px; font-family: times new roman;">）<span style="font-size: 18px; font-family: 宋体,SimSun;">的创始人，本研究得到了名流制药株式会社</span>（</span><a href="https://cerebro-p.com/company/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Cerebro Pharma Inc.<span style="font-size: 18px; font-family: 宋体; color: windowtext;">）</span></span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">和帝人公司</span><span style="font-size: 18px; font-family: times new roman;">（</span><a href="https://www.teijin.com/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Teijin Ltd.</span></a><span style="font-size: 18px; font-family: times new roman;">）<span style="font-size: 18px; font-family: 宋体,SimSun;">的资助</span>。</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">上述介绍，仅供参考。欲了解更多信息，敬请注意浏览</span><a href="https://doi.org/10.7554/eLife.100737.1" style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: 宋体,SimSun;">原文</span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">或者</span><a href="https://scitechdaily.com/natural-remedy-reverses-alzheimers-symptoms-in-new-study/" style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: 宋体,SimSun;">相关报道</span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">。</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;"></span></p><p style="text-align: center;"><a href="https://www.omu.ac.jp/en/info/research-news/entry-65861.html" target="_self" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Chinese herbal medicine’s potential in preventing dementia</span></a></p><p style="line-height: 2em;"><a href="https://doi.org/10.7554/eLife.100737.1" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Abstract</span></a></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;">Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these diseases to remove toxic proteins, repair damaged neurons, and suppress cellular senescence. As a source for such prophylactic agents, we selected <em>Zizyphi spinosi semen</em> (ZSS), a medicinal herb used in traditional Chinese medicine. ZSS hot water extract ameliorated Aβ and tau pathology and cognitive impairment in mouse models of Alzheimer’s disease and frontotemporal dementia. Non-extracted ZSS simple crush powder showed stronger effects than the extract and improved α-synuclein pathology and cognitive/motor function in Parkinson’s disease model mice. Furthermore, when administered to normal aged mice, the ZSS powder suppressed cellular senescence, reduced DNA oxidation, promoted brain-derived neurotrophic factor expression and neurogenesis, and enhanced cognition to levels similar to those in young mice. The quantity of known active ingredients of ZSS, jujuboside A, jujuboside B, and spinosin, was not proportional to the nootropic activity of ZSS. These results suggest that ZSS simple crush powder is a promising dietary material for the prevention of neurodegenerative diseases and brain aging.</span></p> <br /><br /> <label style="font-size:13px; color:#850f0f">转载本文请联系原作者获取授权，同时请注明本文来自诸平科学网博客。<br />链接地址：</label><a href="https://blog.sciencenet.cn/blog-212210-1461217.html" target="_blank" style="font-size:13px; color:#850f0f">https://blog.sciencenet.cn/blog-212210-1461217.html </a> <br /><br />上一篇：<a href='blog-212210-1461053.html' target='_black'>类风湿关节炎个体化治疗的新方法</a><br />下一篇：<a href='blog-212210-1461340.html' target='_black'>这一化学突破可能会改变从医学到农业的一切</a>  </div> <div id="click_div"><table cellpadding="0" cellspacing="0" class="atd"> <tr></tr> </table> <script type="text/javascript"> function errorhandle_clickhandle(message, values) { if(values['id']) { showCreditPrompt(); show_click(values['idtype'], values['id'], values['clickid']); } } </script> </div> <div class="o cl">   <div id="shareblog"></div>  <a href="https://blog.sciencenet.cn/home.php?mod=spacecp&ac=favorite&type=blog&id=1461217&spaceuid=212210&handlekey=favoritebloghk_1461217" id="a_favorite" onclick="showWindow(this.id, this.href, 'get', 0);" class="oshr ofav">收藏</a>  IP: 111.20.218.*<span class="pipe">|</span> <a href="https://blog.sciencenet.cn/home.php?mod=spacecp&ac=blog&blogid=1461217&op=edithot&handlekey=bloghothk_1461217" id="blog_hot_1461217" onclick="showWindow(this.id, this.href, 'get', 0);">热度</a><span class="pipe">|</span>  </div> </div> <div class="ct_vw cl">  <div> <div id="div_main_content" class="mbm">  <h4 class="bbs pbn"> <span><label>当前推荐数：</label><font color="#FF0000" id="recommendcount">3</font> <label style="margin-left:10px;" id="recommendtag">推荐人：</label> <span id="recommendbody"> <a href="https://blog.sciencenet.cn/home.php?mod=space&uid=41701" style="margin-right:5px; 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