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Sometido a Un Tratamiento Térmico" class="work-thumbnail" src="https://attachments.academia-assets.com/120738377/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/126931010/Recuperaci%C3%B3n_Del_F%C3%B3sforo_Presente_en_El_Bios%C3%B3lido_Despu%C3%A9s_De_Ser_Sometido_a_Un_Tratamiento_T%C3%A9rmico">Recuperación Del Fósforo Presente en El Biosólido Después De Ser Sometido a Un Tratamiento Térmico</a></div><div class="wp-workCard_item"><span>DYNA ENERGIA Y SOSTENIBILIDAD</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d3424890e9e2655e242102e4beec804d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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href="https://www.academia.edu/119659111/Re_Lambert_SR_Should_glasses_be_prescribed_for_all_children_with_moderate_hyperopia_Ophthalmology_2016_123_676_8_"><img alt="Research paper thumbnail of Re: Lambert SR: Should glasses be prescribed for all children with moderate hyperopia? 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(Ophthalmology 2016;123:676-8)","internal_url":"https://www.academia.edu/119659111/Re_Lambert_SR_Should_glasses_be_prescribed_for_all_children_with_moderate_hyperopia_Ophthalmology_2016_123_676_8_","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659110/3598_Inter_Screener_Agreement_in_Refractive_Error_Measurements_between_Nurse_and_Lay_Screener_in_Administering_Retinomax_and_SureSight"><img alt="Research paper thumbnail of 3598 Inter-Screener Agreement in Refractive Error Measurements between Nurse and Lay Screener in Administering Retinomax and SureSight" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659110/3598_Inter_Screener_Agreement_in_Refractive_Error_Measurements_between_Nurse_and_Lay_Screener_in_Administering_Retinomax_and_SureSight">3598 Inter-Screener Agreement in Refractive Error Measurements between Nurse and Lay Screener in Administering Retinomax and SureSight</a></div><div class="wp-workCard_item"><span>SciVee</span><span>, Mar 12, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659110; 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</script> <div class="js-work-strip profile--work_container" data-work-id="119659109"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659109/Myopia_in_Amish_Families_Linked_to_Five_Chromosomes"><img alt="Research paper thumbnail of Myopia in Amish Families Linked to Five Chromosomes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659109/Myopia_in_Amish_Families_Linked_to_Five_Chromosomes">Myopia in Amish Families Linked to Five Chromosomes</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Jul 13, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659109"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659109"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659109; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659109]").text(description); $(".js-view-count[data-work-id=119659109]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659109; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659109']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659109]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659109,"title":"Myopia in Amish Families Linked to Five Chromosomes","internal_url":"https://www.academia.edu/119659109/Myopia_in_Amish_Families_Linked_to_Five_Chromosomes","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659108/The_Association_between_Anisometropia_Measured_by_Vector_Analysis_and_Unilateral_Amblyopia_in_Preschoolers"><img alt="Research paper thumbnail of The Association between Anisometropia Measured by Vector Analysis and Unilateral Amblyopia in Preschoolers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659108/The_Association_between_Anisometropia_Measured_by_Vector_Analysis_and_Unilateral_Amblyopia_in_Preschoolers">The Association between Anisometropia Measured by Vector Analysis and Unilateral Amblyopia in Preschoolers</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Apr 22, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659108; 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</script> <div class="js-work-strip profile--work_container" data-work-id="119659107"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659107/Association_between_Amblyopia_and_Spherical_and_Cylindrical_Anisometropia_in_Preschoolers"><img alt="Research paper thumbnail of Association between Amblyopia and Spherical and Cylindrical Anisometropia in Preschoolers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659107/Association_between_Amblyopia_and_Spherical_and_Cylindrical_Anisometropia_in_Preschoolers">Association between Amblyopia and Spherical and Cylindrical Anisometropia in Preschoolers</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Apr 22, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659107"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659107"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659107; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659107]").text(description); $(".js-view-count[data-work-id=119659107]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659107; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659107']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659107]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659107,"title":"Association between Amblyopia and Spherical and Cylindrical Anisometropia in Preschoolers","internal_url":"https://www.academia.edu/119659107/Association_between_Amblyopia_and_Spherical_and_Cylindrical_Anisometropia_in_Preschoolers","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659106"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659106/Genomewide_scan_in_Ashkenazi_Jewish_families_demonstrates_evidence_of_linkage_of_ocular_refraction_to_a_QTL_on_chromosome_1p36"><img alt="Research paper thumbnail of Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36" class="work-thumbnail" src="https://attachments.academia-assets.com/115032401/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659106/Genomewide_scan_in_Ashkenazi_Jewish_families_demonstrates_evidence_of_linkage_of_ocular_refraction_to_a_QTL_on_chromosome_1p36">Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36</a></div><div class="wp-workCard_item"><span>Human Genetics</span><span>, Feb 24, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The development of refractive error is mediated by both environmental and genetic factors. We per...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The development of refractive error is mediated by both environmental and genetic factors. We performed regression-based quantitative trait locus (QTL) linkage analysis on Ashkenazi Jewish families to identify regions in the genome responsible for ocular refraction. We measured refractive error on individuals in 49 multi-generational American families of Ashkenazi Jewish descent. The average family size was 11.1 individuals and was composed of 2.7 generations. Recruitment criteria specified that each family contain at least two myopic members. The mean spherical equivalent refractive error in the sample was −3.46D (SD=3.29) and 87% of individuals were myopic. Microsatellite genotyping with 387 markers was performed on 411 individuals. We performed multipoint regression-based linkage analysis for ocular refraction and a log transformation of the trait using the statistical package Merlin-Regress. Empirical genomewide significance levels were estimated through gene-dropping simulations by generating random genotypes at each of the 387 markers in 200 replicates of our pedigrees. Maximum LOD scores of 9.5 for ocular refraction and 8.7 for log-transformed refraction (LTR) were observed at 49.1 cM on chromosome 1p36 between markers D1S552 and D1S1622. The empirical genomewide significance levels were P=0.065 for ocular refraction and P<0.005 for LTR, providing strong evidence for linkage of refraction to this locus. The inter-marker region containing the peak spans 11 Mb and contains approximately 189 genes. Conclusion: We found genomewide significant</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="accd0ee9b9718bdd377f151332c3f66e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032401,"asset_id":119659106,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032401/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659106"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659106"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659106; 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Methods: Cycloplegic and manifest refraction were measured and individuals with–1.00 D ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659100"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659100"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659100; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659100]").text(description); $(".js-view-count[data-work-id=119659100]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659100; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659100']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659100]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659100,"title":"Genomic Wide Linkage of Familial Myopia and evidence for a locus on chromosome 22","internal_url":"https://www.academia.edu/119659100/Genomic_Wide_Linkage_of_Familial_Myopia_and_evidence_for_a_locus_on_chromosome_22","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659097"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659097/Genome_wide_scan_of_additional_Jewish_families_confirms_linkage_of_a_myopia_susceptibility_locus_to_chromosome_22q12"><img alt="Research paper thumbnail of Genome-wide scan of additional Jewish families confirms linkage of a myopia susceptibility locus to chromosome 22q12" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659097/Genome_wide_scan_of_additional_Jewish_families_confirms_linkage_of_a_myopia_susceptibility_locus_to_chromosome_22q12">Genome-wide scan of additional Jewish families confirms linkage of a myopia susceptibility locus to chromosome 22q12</a></div><div class="wp-workCard_item"><span>PubMed</span><span>, Dec 4, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose: A genome-wide scan was previously reported for myopia in Ashkenazi Jews. In order to con...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose: A genome-wide scan was previously reported for myopia in Ashkenazi Jews. In order to confirm the previous linkage peaks, a collection of DNA samples from 19 new Ashkenazi Jewish families were tested for linkage in a genome wide scan. Methods: Families were ascertained from an Orthodox Ashkenazi Jewish community through mailings. Myopia was defined as equal to or greater than -1 diopter in both meridians in both eyes. The genome wide scan used markers from a modified Cooperative Human Linkage Center version 9 (402 markers). Parametric two-point linkage was calculated with FASTLINK while multipoint linkage was calculated with GENEHUNTER. Results: The results for the 19 families demonstrated several regions of suggestive linkage on chromosomes 7, 1, 17, and 22. A combined analysis of the 19 families and 44 previously reported families demonstrated an increase in the LOD score to 4.73 for the chromosome 22 locus. Conclusions: Multiple chromosomal regions have exhibited some evidence of linkage to a myopia susceptibility gene in this Ashkenazi Jewish population. The strongest evidence of linkage to such a susceptibility gene in these data is on chromosome 22.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659097"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659097"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659097; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659097]").text(description); $(".js-view-count[data-work-id=119659097]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659097']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659097]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659097,"title":"Genome-wide scan of additional Jewish families confirms linkage of a myopia susceptibility locus to chromosome 22q12","internal_url":"https://www.academia.edu/119659097/Genome_wide_scan_of_additional_Jewish_families_confirms_linkage_of_a_myopia_susceptibility_locus_to_chromosome_22q12","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659096"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659096/Genome_wide_Scan_of_African_American_and_White_Families_for_Linkage_to_Myopia"><img alt="Research paper thumbnail of Genome-wide Scan of African-American and White Families for Linkage to Myopia" class="work-thumbnail" src="https://attachments.academia-assets.com/115032391/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659096/Genome_wide_Scan_of_African_American_and_White_Families_for_Linkage_to_Myopia">Genome-wide Scan of African-American and White Families for Linkage to Myopia</a></div><div class="wp-workCard_item"><span>American Journal of Ophthalmology</span><span>, Mar 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">PURPOSE-To identify myopia susceptibility genes influencing common myopia in 94 African-American ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">PURPOSE-To identify myopia susceptibility genes influencing common myopia in 94 African-American and 36 White families. DESIGN-A prospective study of families with myopia consisting of a minimum of two individuals affected with myopia. METHODS-Extended families consisting of at least two siblings affected with myopia were ascertained. A genome-wide linkage scan using 387 markers was conducted by the Center for Inherited Disease Research. Linkage analyses were conducted with parametric and nonparametric methods. Model-free linkage analysis was performed maximizing over penetrance and over dominance (that is, fitting a wide range of both dominant and recessive models). RESULTS-Under the model-free analysis, the maximum two point heterogeneity logarithm of the odds score (MALOD) was 2.87 at D6S1009 in the White cohort and the maximum multipoint MALOD was 2.42 at D12S373-D12S1042 in the same cohort. The nonpara-metric linkage (NPL) maximum multipoint at D6S1035 had a P value of .005. An overall multipoint NPL score was obtained by combining NPL scores from both populations. The highest combined NPL score was observed at D20S478 with a significant P value of .008. Suggestive evidence of linkage in the White cohort mapped to a previously mapped locus on chromosome 11 at D11S1981 (NPL = 2.14; P = .02). CONCLUSIONS-Suggestive evidence of linkage to myopia in both African Americans and Whites was seen on chromosome 20 and became more significant when the scores were combined for both groups. The locus on chromosome 11 independently confirms a report by Hammond and associates mapping a myopia quantitative trait locus to this region. The prevalence of myopia has increased over the last several decades. Myopia is expected to affect 10% to 25% of adults in the United States, Europe, and Australia. 1-3 Prevalences of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e39e11ce6267725a75ec67ec18ea858" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032391,"asset_id":119659096,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032391/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659096"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659096"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659096; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659096]").text(description); $(".js-view-count[data-work-id=119659096]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659096; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659096']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e39e11ce6267725a75ec67ec18ea858" } } $('.js-work-strip[data-work-id=119659096]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659096,"title":"Genome-wide Scan of African-American and White Families for Linkage to Myopia","internal_url":"https://www.academia.edu/119659096/Genome_wide_Scan_of_African_American_and_White_Families_for_Linkage_to_Myopia","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[{"id":115032391,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115032391/thumbnails/1.jpg","file_name":"pmc4152232.pdf","download_url":"https://www.academia.edu/attachments/115032391/download_file","bulk_download_file_name":"Genome_wide_Scan_of_African_American_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115032391/pmc4152232-libre.pdf?1716218233=\u0026response-content-disposition=attachment%3B+filename%3DGenome_wide_Scan_of_African_American_and.pdf\u0026Expires=1739949052\u0026Signature=gkZQW~7po3TKFnOmo4t2INAo6HLJSTOMbTa0ZVW5FqgpY-Mbv1FXptXEAcfsw0QHJLrkzOJA4DZjwD7lsyIFEbULXSuN0nvtmLJ9vZb30UqMC32Cmvr4P3Ws7kocEAXM4Qd0nV8ofVgwRTJpWWAwonN0CEswWRcawUebki7ZDdN5KBUaRNPaAOx5q8hn4erP-n8CEjyGn2AQ7jBJkPCkTTAWwPd1xnriQ3dnnR5djq16sRAKLiFdAC0GHNyBi6EjMDM3GZky~I~IbVTVGk8XWri1tXgFu-XLhz3nUAgipuGJx4FD2SQXCmRuQYmAdnGRmwoGqgwgMRSMcKVyv0nhYg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115032392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115032392/thumbnails/1.jpg","file_name":"pmc4152232.pdf","download_url":"https://www.academia.edu/attachments/115032392/download_file","bulk_download_file_name":"Genome_wide_Scan_of_African_American_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115032392/pmc4152232-libre.pdf?1716218233=\u0026response-content-disposition=attachment%3B+filename%3DGenome_wide_Scan_of_African_American_and.pdf\u0026Expires=1739949052\u0026Signature=c4HpNFix9y2MAOOB3JIexdGUGxW8556ASsDJwlPE2LDvP3oU~D0g9CH6DNLsK3LbRV~OplW5cLDUn-g3PqtlVchoHXY~l6zog7jOBdO-KWn6GZ2B4y6hF~3VQ6mVJmNdouqarCvUvb5-u1vna2m2R9BoN9t84kl2kolYY~EJU2MY9Q7yyTXkivU9eQ6vV~9E4mGI5JJEvDx6fIbuZY-w8MXO6dy6oPFNVtzHeIsjq0UzWLW9cEvfxdkJ5D0OKNxjZu~ArQ3wWdI0KdjOcBLqgEB3utCGuCLSxmL6nNd1ZJXHkSn8rnuMK7FTQbJycS-y5k0egmHp3BRBbOKNA2P08A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659095"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659095/Candidate_high_myopia_loci_on_chromosomes_18p_and_12q_do_not_play_a_major_role_in_susceptibility_to_common_myopia"><img alt="Research paper thumbnail of Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia" class="work-thumbnail" src="https://attachments.academia-assets.com/115032390/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659095/Candidate_high_myopia_loci_on_chromosomes_18p_and_12q_do_not_play_a_major_role_in_susceptibility_to_common_myopia">Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia</a></div><div class="wp-workCard_item"><span>BMC Medical Genetics</span><span>, Aug 3, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: To determine whether previously reported loci predisposing to nonsyndromic high myopi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: To determine whether previously reported loci predisposing to nonsyndromic high myopia show linkage to common myopia in pedigrees from two ethnic groups: Ashkenazi Jewish and Amish. We hypothesized that these high myopia loci might exhibit allelic heterogeneity and be responsible for moderate /mild or common myopia. Methods: Cycloplegic and manifest refraction were performed on 38 Jewish and 40 Amish families. Individuals with at least-1.00 D in each meridian of both eyes were classified as myopic. Genomic DNA was genotyped with 12 markers on chromosomes 12q21-23 and 18p11.3. Parametric and nonparametric linkage analyses were conducted to determine whether susceptibility alleles at these loci are important in families with less severe, clinical forms of myopia. Results: There was no strong evidence of linkage of common myopia to these candidate regions: all two-point and multipoint heterogeneity LOD scores were < 1.0 and non-parametric linkage pvalues were > 0.01. However, one Amish family showed slight evidence of linkage (LOD>1.0) on 12q; another 3 Amish families each gave LOD >1.0 on 18p; and 3 Jewish families each gave LOD >1.0 on 12q. Conclusions: Significant evidence of linkage (LOD> 3) of myopia was not found on chromosome 18p or 12q loci in these families. These results suggest that these loci do not play a major role in the causation of common myopia in our families studied.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae4e0d7b3d77d1575c715c0641f9d5fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032390,"asset_id":119659095,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032390/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659095"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659095"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659095; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659090"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659090/Sensitivity_of_Screening_Tests_for_Detecting_Vision_In_Preschoolers_targeted_Vision_Disorders_When_Specificity_Is_94_"><img alt="Research paper thumbnail of Sensitivity of Screening Tests for Detecting Vision In Preschoolers-targeted Vision Disorders When Specificity Is 94%" class="work-thumbnail" src="https://attachments.academia-assets.com/115032469/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659090/Sensitivity_of_Screening_Tests_for_Detecting_Vision_In_Preschoolers_targeted_Vision_Disorders_When_Specificity_Is_94_">Sensitivity of Screening Tests for Detecting Vision In Preschoolers-targeted Vision Disorders When Specificity Is 94%</a></div><div class="wp-workCard_item"><span>Optometry and Vision Science</span><span>, May 1, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose. To compare the sensitivity of 11 preschool vision screening tests administered by licens...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose. To compare the sensitivity of 11 preschool vision screening tests administered by licensed eye care professionals for the detection of the 4 Vision in Preschoolers (VIP)-targeted vision disorders when specificity is 94%. Methods. This study consisted of a sample (n ‫؍‬ 2588) of 3-to 5-year-old children enrolled in Head Start programs, 57% of whom had failed an initial Head Start vision screening. Screening results from 11 tests were compared with results from a standardized comprehensive eye examination that was used to classify children with respect to the four VIP-targeted vision disorders: amblyopia, strabismus, significant refractive error, and unexplained reduced visual acuity (VA). With overall specificity set to 94%, we calculated the sensitivity for the detection of each targeted vision disorder. Results. With the overall specificity set to 94%, the most accurate tests for detection of amblyopia were noncycloplegic retinoscopy (NCR) (88% sensitivity), the SureSight Vision Screener (80%), and the Retinomax Autorefractor (78%). For detection of strabismus, the most accurate tests were the MTI Photoscreener (65%), the cover-uncover test (60%), the Stereo Smile II stereoacuity test (58%), the SureSight Vision Screener (54%), and the Retinomax Autorefractor (54% in year 1, 53% in year 2). The most accurate tests for detection of significant refractive error were NCR (74%), the Retinomax Autorefractor (66%), the SureSight Vision Screener (63%), and the Lea Symbols VA test (58%). For detection of reduced VA, the most accurate tests were the Lea Symbols Distance VA test (48%), the Retinomax Autorefractor (39%), and NCR (38%). Conclusions. Similar to the previously reported results at 90% specificity, the screening tests vary widely in sensitivity with specificity set at 94%. The rankings of the sensitivities for detection of the 4 VIP-targeted vision disorders are similar to those with specificity set to 90%.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4aa25a7a0ff9b03682cd952cf6f3335b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032469,"asset_id":119659090,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032469/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659090"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659090"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659090; 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(Ophthalmology 2016;123:676-8)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659111/Re_Lambert_SR_Should_glasses_be_prescribed_for_all_children_with_moderate_hyperopia_Ophthalmology_2016_123_676_8_">Re: Lambert SR: Should glasses be prescribed for all children with moderate hyperopia? 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(Ophthalmology 2016;123:676-8)","internal_url":"https://www.academia.edu/119659111/Re_Lambert_SR_Should_glasses_be_prescribed_for_all_children_with_moderate_hyperopia_Ophthalmology_2016_123_676_8_","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659110/3598_Inter_Screener_Agreement_in_Refractive_Error_Measurements_between_Nurse_and_Lay_Screener_in_Administering_Retinomax_and_SureSight"><img alt="Research paper thumbnail of 3598 Inter-Screener Agreement in Refractive Error Measurements between Nurse and Lay Screener in Administering Retinomax and SureSight" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659110/3598_Inter_Screener_Agreement_in_Refractive_Error_Measurements_between_Nurse_and_Lay_Screener_in_Administering_Retinomax_and_SureSight">3598 Inter-Screener Agreement in Refractive Error Measurements between Nurse and Lay Screener in Administering Retinomax and SureSight</a></div><div class="wp-workCard_item"><span>SciVee</span><span>, Mar 12, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659110; 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</script> <div class="js-work-strip profile--work_container" data-work-id="119659109"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659109/Myopia_in_Amish_Families_Linked_to_Five_Chromosomes"><img alt="Research paper thumbnail of Myopia in Amish Families Linked to Five Chromosomes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659109/Myopia_in_Amish_Families_Linked_to_Five_Chromosomes">Myopia in Amish Families Linked to Five Chromosomes</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Jul 13, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659109"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659109"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659109; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659109]").text(description); $(".js-view-count[data-work-id=119659109]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659109; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659109']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659109]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659109,"title":"Myopia in Amish Families Linked to Five Chromosomes","internal_url":"https://www.academia.edu/119659109/Myopia_in_Amish_Families_Linked_to_Five_Chromosomes","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659108/The_Association_between_Anisometropia_Measured_by_Vector_Analysis_and_Unilateral_Amblyopia_in_Preschoolers"><img alt="Research paper thumbnail of The Association between Anisometropia Measured by Vector Analysis and Unilateral Amblyopia in Preschoolers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659108/The_Association_between_Anisometropia_Measured_by_Vector_Analysis_and_Unilateral_Amblyopia_in_Preschoolers">The Association between Anisometropia Measured by Vector Analysis and Unilateral Amblyopia in Preschoolers</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Apr 22, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659108; 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</script> <div class="js-work-strip profile--work_container" data-work-id="119659107"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659107/Association_between_Amblyopia_and_Spherical_and_Cylindrical_Anisometropia_in_Preschoolers"><img alt="Research paper thumbnail of Association between Amblyopia and Spherical and Cylindrical Anisometropia in Preschoolers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659107/Association_between_Amblyopia_and_Spherical_and_Cylindrical_Anisometropia_in_Preschoolers">Association between Amblyopia and Spherical and Cylindrical Anisometropia in Preschoolers</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Apr 22, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659107"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659107"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659107; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659107]").text(description); $(".js-view-count[data-work-id=119659107]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659107; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659107']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659107]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659107,"title":"Association between Amblyopia and Spherical and Cylindrical Anisometropia in Preschoolers","internal_url":"https://www.academia.edu/119659107/Association_between_Amblyopia_and_Spherical_and_Cylindrical_Anisometropia_in_Preschoolers","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659106"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659106/Genomewide_scan_in_Ashkenazi_Jewish_families_demonstrates_evidence_of_linkage_of_ocular_refraction_to_a_QTL_on_chromosome_1p36"><img alt="Research paper thumbnail of Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36" class="work-thumbnail" src="https://attachments.academia-assets.com/115032401/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659106/Genomewide_scan_in_Ashkenazi_Jewish_families_demonstrates_evidence_of_linkage_of_ocular_refraction_to_a_QTL_on_chromosome_1p36">Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36</a></div><div class="wp-workCard_item"><span>Human Genetics</span><span>, Feb 24, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The development of refractive error is mediated by both environmental and genetic factors. We per...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The development of refractive error is mediated by both environmental and genetic factors. We performed regression-based quantitative trait locus (QTL) linkage analysis on Ashkenazi Jewish families to identify regions in the genome responsible for ocular refraction. We measured refractive error on individuals in 49 multi-generational American families of Ashkenazi Jewish descent. The average family size was 11.1 individuals and was composed of 2.7 generations. Recruitment criteria specified that each family contain at least two myopic members. The mean spherical equivalent refractive error in the sample was −3.46D (SD=3.29) and 87% of individuals were myopic. Microsatellite genotyping with 387 markers was performed on 411 individuals. We performed multipoint regression-based linkage analysis for ocular refraction and a log transformation of the trait using the statistical package Merlin-Regress. Empirical genomewide significance levels were estimated through gene-dropping simulations by generating random genotypes at each of the 387 markers in 200 replicates of our pedigrees. Maximum LOD scores of 9.5 for ocular refraction and 8.7 for log-transformed refraction (LTR) were observed at 49.1 cM on chromosome 1p36 between markers D1S552 and D1S1622. The empirical genomewide significance levels were P=0.065 for ocular refraction and P<0.005 for LTR, providing strong evidence for linkage of refraction to this locus. The inter-marker region containing the peak spans 11 Mb and contains approximately 189 genes. Conclusion: We found genomewide significant</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="accd0ee9b9718bdd377f151332c3f66e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032401,"asset_id":119659106,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032401/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659106"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659106"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659106; 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Methods: Cycloplegic and manifest refraction were measured and individuals with–1.00 D ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659100"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659100"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659100; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659100]").text(description); $(".js-view-count[data-work-id=119659100]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659100; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659100']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659100]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659100,"title":"Genomic Wide Linkage of Familial Myopia and evidence for a locus on chromosome 22","internal_url":"https://www.academia.edu/119659100/Genomic_Wide_Linkage_of_Familial_Myopia_and_evidence_for_a_locus_on_chromosome_22","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659097"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659097/Genome_wide_scan_of_additional_Jewish_families_confirms_linkage_of_a_myopia_susceptibility_locus_to_chromosome_22q12"><img alt="Research paper thumbnail of Genome-wide scan of additional Jewish families confirms linkage of a myopia susceptibility locus to chromosome 22q12" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659097/Genome_wide_scan_of_additional_Jewish_families_confirms_linkage_of_a_myopia_susceptibility_locus_to_chromosome_22q12">Genome-wide scan of additional Jewish families confirms linkage of a myopia susceptibility locus to chromosome 22q12</a></div><div class="wp-workCard_item"><span>PubMed</span><span>, Dec 4, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose: A genome-wide scan was previously reported for myopia in Ashkenazi Jews. In order to con...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose: A genome-wide scan was previously reported for myopia in Ashkenazi Jews. In order to confirm the previous linkage peaks, a collection of DNA samples from 19 new Ashkenazi Jewish families were tested for linkage in a genome wide scan. Methods: Families were ascertained from an Orthodox Ashkenazi Jewish community through mailings. Myopia was defined as equal to or greater than -1 diopter in both meridians in both eyes. The genome wide scan used markers from a modified Cooperative Human Linkage Center version 9 (402 markers). Parametric two-point linkage was calculated with FASTLINK while multipoint linkage was calculated with GENEHUNTER. Results: The results for the 19 families demonstrated several regions of suggestive linkage on chromosomes 7, 1, 17, and 22. A combined analysis of the 19 families and 44 previously reported families demonstrated an increase in the LOD score to 4.73 for the chromosome 22 locus. Conclusions: Multiple chromosomal regions have exhibited some evidence of linkage to a myopia susceptibility gene in this Ashkenazi Jewish population. The strongest evidence of linkage to such a susceptibility gene in these data is on chromosome 22.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659097"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659097"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659097; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659097]").text(description); $(".js-view-count[data-work-id=119659097]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659097']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=119659097]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659097,"title":"Genome-wide scan of additional Jewish families confirms linkage of a myopia susceptibility locus to chromosome 22q12","internal_url":"https://www.academia.edu/119659097/Genome_wide_scan_of_additional_Jewish_families_confirms_linkage_of_a_myopia_susceptibility_locus_to_chromosome_22q12","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659096"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659096/Genome_wide_Scan_of_African_American_and_White_Families_for_Linkage_to_Myopia"><img alt="Research paper thumbnail of Genome-wide Scan of African-American and White Families for Linkage to Myopia" class="work-thumbnail" src="https://attachments.academia-assets.com/115032391/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659096/Genome_wide_Scan_of_African_American_and_White_Families_for_Linkage_to_Myopia">Genome-wide Scan of African-American and White Families for Linkage to Myopia</a></div><div class="wp-workCard_item"><span>American Journal of Ophthalmology</span><span>, Mar 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">PURPOSE-To identify myopia susceptibility genes influencing common myopia in 94 African-American ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">PURPOSE-To identify myopia susceptibility genes influencing common myopia in 94 African-American and 36 White families. DESIGN-A prospective study of families with myopia consisting of a minimum of two individuals affected with myopia. METHODS-Extended families consisting of at least two siblings affected with myopia were ascertained. A genome-wide linkage scan using 387 markers was conducted by the Center for Inherited Disease Research. Linkage analyses were conducted with parametric and nonparametric methods. Model-free linkage analysis was performed maximizing over penetrance and over dominance (that is, fitting a wide range of both dominant and recessive models). RESULTS-Under the model-free analysis, the maximum two point heterogeneity logarithm of the odds score (MALOD) was 2.87 at D6S1009 in the White cohort and the maximum multipoint MALOD was 2.42 at D12S373-D12S1042 in the same cohort. The nonpara-metric linkage (NPL) maximum multipoint at D6S1035 had a P value of .005. An overall multipoint NPL score was obtained by combining NPL scores from both populations. The highest combined NPL score was observed at D20S478 with a significant P value of .008. Suggestive evidence of linkage in the White cohort mapped to a previously mapped locus on chromosome 11 at D11S1981 (NPL = 2.14; P = .02). CONCLUSIONS-Suggestive evidence of linkage to myopia in both African Americans and Whites was seen on chromosome 20 and became more significant when the scores were combined for both groups. The locus on chromosome 11 independently confirms a report by Hammond and associates mapping a myopia quantitative trait locus to this region. The prevalence of myopia has increased over the last several decades. Myopia is expected to affect 10% to 25% of adults in the United States, Europe, and Australia. 1-3 Prevalences of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e39e11ce6267725a75ec67ec18ea858" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032391,"asset_id":119659096,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032391/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659096"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659096"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659096; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=119659096]").text(description); $(".js-view-count[data-work-id=119659096]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 119659096; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='119659096']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e39e11ce6267725a75ec67ec18ea858" } } $('.js-work-strip[data-work-id=119659096]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":119659096,"title":"Genome-wide Scan of African-American and White Families for Linkage to Myopia","internal_url":"https://www.academia.edu/119659096/Genome_wide_Scan_of_African_American_and_White_Families_for_Linkage_to_Myopia","owner_id":33522260,"coauthors_can_edit":true,"owner":{"id":33522260,"first_name":"Elise","middle_initials":null,"last_name":"Ciner","page_name":"EliseCiner","domain_name":"independent","created_at":"2015-08-01T18:49:06.335-07:00","display_name":"Elise Ciner","url":"https://independent.academia.edu/EliseCiner"},"attachments":[{"id":115032391,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115032391/thumbnails/1.jpg","file_name":"pmc4152232.pdf","download_url":"https://www.academia.edu/attachments/115032391/download_file","bulk_download_file_name":"Genome_wide_Scan_of_African_American_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115032391/pmc4152232-libre.pdf?1716218233=\u0026response-content-disposition=attachment%3B+filename%3DGenome_wide_Scan_of_African_American_and.pdf\u0026Expires=1739949052\u0026Signature=gkZQW~7po3TKFnOmo4t2INAo6HLJSTOMbTa0ZVW5FqgpY-Mbv1FXptXEAcfsw0QHJLrkzOJA4DZjwD7lsyIFEbULXSuN0nvtmLJ9vZb30UqMC32Cmvr4P3Ws7kocEAXM4Qd0nV8ofVgwRTJpWWAwonN0CEswWRcawUebki7ZDdN5KBUaRNPaAOx5q8hn4erP-n8CEjyGn2AQ7jBJkPCkTTAWwPd1xnriQ3dnnR5djq16sRAKLiFdAC0GHNyBi6EjMDM3GZky~I~IbVTVGk8XWri1tXgFu-XLhz3nUAgipuGJx4FD2SQXCmRuQYmAdnGRmwoGqgwgMRSMcKVyv0nhYg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115032392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115032392/thumbnails/1.jpg","file_name":"pmc4152232.pdf","download_url":"https://www.academia.edu/attachments/115032392/download_file","bulk_download_file_name":"Genome_wide_Scan_of_African_American_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115032392/pmc4152232-libre.pdf?1716218233=\u0026response-content-disposition=attachment%3B+filename%3DGenome_wide_Scan_of_African_American_and.pdf\u0026Expires=1739949052\u0026Signature=c4HpNFix9y2MAOOB3JIexdGUGxW8556ASsDJwlPE2LDvP3oU~D0g9CH6DNLsK3LbRV~OplW5cLDUn-g3PqtlVchoHXY~l6zog7jOBdO-KWn6GZ2B4y6hF~3VQ6mVJmNdouqarCvUvb5-u1vna2m2R9BoN9t84kl2kolYY~EJU2MY9Q7yyTXkivU9eQ6vV~9E4mGI5JJEvDx6fIbuZY-w8MXO6dy6oPFNVtzHeIsjq0UzWLW9cEvfxdkJ5D0OKNxjZu~ArQ3wWdI0KdjOcBLqgEB3utCGuCLSxmL6nNd1ZJXHkSn8rnuMK7FTQbJycS-y5k0egmHp3BRBbOKNA2P08A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659095"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659095/Candidate_high_myopia_loci_on_chromosomes_18p_and_12q_do_not_play_a_major_role_in_susceptibility_to_common_myopia"><img alt="Research paper thumbnail of Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia" class="work-thumbnail" src="https://attachments.academia-assets.com/115032390/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659095/Candidate_high_myopia_loci_on_chromosomes_18p_and_12q_do_not_play_a_major_role_in_susceptibility_to_common_myopia">Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia</a></div><div class="wp-workCard_item"><span>BMC Medical Genetics</span><span>, Aug 3, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: To determine whether previously reported loci predisposing to nonsyndromic high myopi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: To determine whether previously reported loci predisposing to nonsyndromic high myopia show linkage to common myopia in pedigrees from two ethnic groups: Ashkenazi Jewish and Amish. We hypothesized that these high myopia loci might exhibit allelic heterogeneity and be responsible for moderate /mild or common myopia. Methods: Cycloplegic and manifest refraction were performed on 38 Jewish and 40 Amish families. Individuals with at least-1.00 D in each meridian of both eyes were classified as myopic. Genomic DNA was genotyped with 12 markers on chromosomes 12q21-23 and 18p11.3. Parametric and nonparametric linkage analyses were conducted to determine whether susceptibility alleles at these loci are important in families with less severe, clinical forms of myopia. Results: There was no strong evidence of linkage of common myopia to these candidate regions: all two-point and multipoint heterogeneity LOD scores were < 1.0 and non-parametric linkage pvalues were > 0.01. However, one Amish family showed slight evidence of linkage (LOD>1.0) on 12q; another 3 Amish families each gave LOD >1.0 on 18p; and 3 Jewish families each gave LOD >1.0 on 12q. Conclusions: Significant evidence of linkage (LOD> 3) of myopia was not found on chromosome 18p or 12q loci in these families. These results suggest that these loci do not play a major role in the causation of common myopia in our families studied.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae4e0d7b3d77d1575c715c0641f9d5fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032390,"asset_id":119659095,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032390/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659095"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659095"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659095; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="119659090"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/119659090/Sensitivity_of_Screening_Tests_for_Detecting_Vision_In_Preschoolers_targeted_Vision_Disorders_When_Specificity_Is_94_"><img alt="Research paper thumbnail of Sensitivity of Screening Tests for Detecting Vision In Preschoolers-targeted Vision Disorders When Specificity Is 94%" class="work-thumbnail" src="https://attachments.academia-assets.com/115032469/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/119659090/Sensitivity_of_Screening_Tests_for_Detecting_Vision_In_Preschoolers_targeted_Vision_Disorders_When_Specificity_Is_94_">Sensitivity of Screening Tests for Detecting Vision In Preschoolers-targeted Vision Disorders When Specificity Is 94%</a></div><div class="wp-workCard_item"><span>Optometry and Vision Science</span><span>, May 1, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose. To compare the sensitivity of 11 preschool vision screening tests administered by licens...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose. To compare the sensitivity of 11 preschool vision screening tests administered by licensed eye care professionals for the detection of the 4 Vision in Preschoolers (VIP)-targeted vision disorders when specificity is 94%. Methods. This study consisted of a sample (n ‫؍‬ 2588) of 3-to 5-year-old children enrolled in Head Start programs, 57% of whom had failed an initial Head Start vision screening. Screening results from 11 tests were compared with results from a standardized comprehensive eye examination that was used to classify children with respect to the four VIP-targeted vision disorders: amblyopia, strabismus, significant refractive error, and unexplained reduced visual acuity (VA). With overall specificity set to 94%, we calculated the sensitivity for the detection of each targeted vision disorder. Results. With the overall specificity set to 94%, the most accurate tests for detection of amblyopia were noncycloplegic retinoscopy (NCR) (88% sensitivity), the SureSight Vision Screener (80%), and the Retinomax Autorefractor (78%). For detection of strabismus, the most accurate tests were the MTI Photoscreener (65%), the cover-uncover test (60%), the Stereo Smile II stereoacuity test (58%), the SureSight Vision Screener (54%), and the Retinomax Autorefractor (54% in year 1, 53% in year 2). The most accurate tests for detection of significant refractive error were NCR (74%), the Retinomax Autorefractor (66%), the SureSight Vision Screener (63%), and the Lea Symbols VA test (58%). For detection of reduced VA, the most accurate tests were the Lea Symbols Distance VA test (48%), the Retinomax Autorefractor (39%), and NCR (38%). Conclusions. Similar to the previously reported results at 90% specificity, the screening tests vary widely in sensitivity with specificity set at 94%. The rankings of the sensitivities for detection of the 4 VIP-targeted vision disorders are similar to those with specificity set to 90%.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4aa25a7a0ff9b03682cd952cf6f3335b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115032469,"asset_id":119659090,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115032469/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659090"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659090"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659090; 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</script> <div class="js-work-strip profile--work_container" data-work-id="119659085"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/119659085/African_American_families_show_genome_wide_significant_linkage_to_myopia_at_7p15_2_14_2"><img alt="Research paper thumbnail of African-American families show genome-wide significant linkage to myopia at 7p15.2-14.2" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/119659085/African_American_families_show_genome_wide_significant_linkage_to_myopia_at_7p15_2_14_2">African-American families show genome-wide significant linkage to myopia at 7p15.2-14.2</a></div><div class="wp-workCard_item"><span>Investigative Ophthalmology & Visual Science</span><span>, Jul 13, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="119659085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="119659085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 119659085; 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