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data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Menu główne</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">przypnij</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">ukryj</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Nawigacja </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Wikipedia:Strona_g%C5%82%C3%B3wna" title="Przejdź na stronę główną [z]" accesskey="z"><span>Strona główna</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Specjalna:Losowa_strona" title="Załaduj losową stronę [x]" accesskey="x"><span>Losuj artykuł</span></a></li><li id="n-Kategorie" class="mw-list-item"><a href="/wiki/Portal:Kategorie_G%C5%82%C3%B3wne"><span>Kategorie artykułów</span></a></li><li id="n-Featured-articles" class="mw-list-item"><a href="/wiki/Wikipedia:Wyr%C3%B3%C5%BCniona_zawarto%C5%9B%C4%87_Wikipedii"><span>Najlepsze artykuły</span></a></li><li id="n-FAQ" class="mw-list-item"><a href="/wiki/Pomoc:FAQ"><span>Częste pytania (FAQ)</span></a></li> </ul> </div> </div> <div id="p-zmiany" class="vector-menu mw-portlet mw-portlet-zmiany" > <div class="vector-menu-heading"> Dla czytelników </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-czytelnicy" class="mw-list-item"><a href="/wiki/Wikipedia:O_Wikipedii"><span>O Wikipedii</span></a></li><li id="n-contact" class="mw-list-item"><a href="/wiki/Wikipedia:Kontakt_z_wikipedystami"><span>Kontakt</span></a></li> </ul> </div> </div> <div id="p-edytorzy" class="vector-menu mw-portlet mw-portlet-edytorzy" > <div class="vector-menu-heading"> Dla wikipedystów </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-pierwsze-kroki" class="mw-list-item"><a href="/wiki/Pomoc:Pierwsze_kroki"><span>Pierwsze kroki</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Portal_wikipedyst%C3%B3w" title="O projekcie – co możesz zrobić, gdzie możesz znaleźć informacje"><span>Portal wikipedystów</span></a></li><li id="n-Noticeboard" class="mw-list-item"><a href="/wiki/Wikipedia:Tablica_og%C5%82osze%C5%84"><span>Ogłoszenia</span></a></li><li id="n-Guidelines" class="mw-list-item"><a href="/wiki/Wikipedia:Zasady"><span>Zasady</span></a></li><li id="n-helppage-name" class="mw-list-item"><a href="/wiki/Pomoc:Spis_tre%C5%9Bci"><span>Pomoc</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Specjalna:Ostatnie_zmiany" title="Lista ostatnich zmian w Wikipedii. [r]" accesskey="r"><span>Ostatnie zmiany</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Wikipedia:Strona_g%C5%82%C3%B3wna" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="wolna encyklopedia" src="/static/images/mobile/copyright/wikipedia-tagline-pl.svg" width="120" height="13" style="width: 7.5em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Specjalna:Szukaj" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Przeszukaj Wikipedię [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Szukaj</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Przeszukaj Wikipedię" aria-label="Przeszukaj Wikipedię" autocapitalize="sentences" title="Przeszukaj Wikipedię [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Specjalna:Szukaj"> </div> <button class="cdx-button cdx-search-input__end-button">Szukaj</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Narzędzia osobiste"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Wygląd"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Zmień rozmiar czcionki, szerokość oraz kolorystykę strony" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Wygląd" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Wygląd</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_pl.wikipedia.org&uselang=pl" class=""><span>Wspomóż Wikipedię</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Specjalna:Utw%C3%B3rz_konto&returnto=Genisteina" title="Zachęcamy do stworzenia konta i zalogowania, ale nie jest to obowiązkowe." class=""><span>Utwórz konto</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Specjalna:Zaloguj&returnto=Genisteina" title="Zachęcamy do zalogowania się, choć nie jest to obowiązkowe. [o]" accesskey="o" class=""><span>Zaloguj się</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Więcej opcji" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Narzędzia osobiste" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Narzędzia osobiste</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Menu użytkownika" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_pl.wikipedia.org&uselang=pl"><span>Wspomóż Wikipedię</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Specjalna:Utw%C3%B3rz_konto&returnto=Genisteina" title="Zachęcamy do stworzenia konta i zalogowania, ale nie jest to obowiązkowe."><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Utwórz konto</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Specjalna:Zaloguj&returnto=Genisteina" title="Zachęcamy do zalogowania się, choć nie jest to obowiązkowe. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Zaloguj się</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Strony dla anonimowych edytorów <a href="/wiki/Pomoc:Pierwsze_kroki" aria-label="Dowiedz się więcej na temat edytowania"><span>dowiedz się więcej</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Specjalna:M%C3%B3j_wk%C5%82ad" title="Lista edycji wykonanych z tego adresu IP [y]" accesskey="y"><span>Edycje</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Specjalna:Moja_dyskusja" title="Dyskusja użytkownika dla tego adresu IP [n]" accesskey="n"><span>Dyskusja</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Witryna"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Spis treści" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Spis treści</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">przypnij</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">ukryj</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Początek</div> </a> </li> <li id="toc-Działanie_przeciwrobacze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Działanie_przeciwrobacze"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Działanie przeciwrobacze</span> </div> </a> <ul id="toc-Działanie_przeciwrobacze-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Działanie_na_komórki_ludzkie" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Działanie_na_komórki_ludzkie"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Działanie na komórki ludzkie</span> </div> </a> <ul id="toc-Działanie_na_komórki_ludzkie-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Zespół_Sanfilippo" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Zespół_Sanfilippo"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Zespół Sanfilippo</span> </div> </a> <ul id="toc-Zespół_Sanfilippo-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Działanie_hormonopodobne" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Działanie_hormonopodobne"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Działanie hormonopodobne</span> </div> </a> <ul id="toc-Działanie_hormonopodobne-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Przypisy" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Przypisy"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Przypisy</span> </div> </a> <ul id="toc-Przypisy-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Spis treści" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Przełącz stan spisu treści" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Przełącz stan spisu treści</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Genisteina</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Przejdź do artykułu w innym języku. Treść dostępna w 24 językach" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-24" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">24 języki</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AC%D9%8A%D9%86%D9%8A%D8%B3%D9%8A%D8%AA%D9%86" title="جينيسيتن – arabski" lang="ar" hreflang="ar" data-title="جينيسيتن" data-language-autonym="العربية" data-language-local-name="arabski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%DA%98%D9%86%DB%8C%D8%B3%D8%AA%D8%A6%DB%8C%D9%86" title="ژنیستئین – South Azerbaijani" lang="azb" hreflang="azb" data-title="ژنیستئین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Geniste%C3%AFna" title="Genisteïna – kataloński" lang="ca" hreflang="ca" data-title="Genisteïna" data-language-autonym="Català" data-language-local-name="kataloński" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Genistein" title="Genistein – niemiecki" lang="de" hreflang="de" data-title="Genistein" data-language-autonym="Deutsch" data-language-local-name="niemiecki" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Genisteiin" title="Genisteiin – estoński" lang="et" hreflang="et" data-title="Genisteiin" data-language-autonym="Eesti" data-language-local-name="estoński" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Genistein" title="Genistein – angielski" lang="en" hreflang="en" data-title="Genistein" data-language-autonym="English" data-language-local-name="angielski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Geniste%C3%ADna" title="Genisteína – hiszpański" lang="es" hreflang="es" data-title="Genisteína" data-language-autonym="Español" data-language-local-name="hiszpański" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Genisteino" title="Genisteino – esperanto" lang="eo" hreflang="eo" data-title="Genisteino" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AC%D9%86%DB%8C%D8%B3%D8%AA%D8%A6%DB%8C%D9%86" title="جنیستئین – perski" lang="fa" hreflang="fa" data-title="جنیستئین" data-language-autonym="فارسی" data-language-local-name="perski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/G%C3%A9nist%C3%A9ine" title="Génistéine – francuski" lang="fr" hreflang="fr" data-title="Génistéine" data-language-autonym="Français" data-language-local-name="francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Genistein" title="Genistein – indonezyjski" lang="id" hreflang="id" data-title="Genistein" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonezyjski" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Genisteina" title="Genisteina – włoski" lang="it" hreflang="it" data-title="Genisteina" data-language-autonym="Italiano" data-language-local-name="włoski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Genisteinas" title="Genisteinas – litewski" lang="lt" hreflang="lt" data-title="Genisteinas" data-language-autonym="Lietuvių" data-language-local-name="litewski" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Geniste%C3%AFne" title="Genisteïne – niderlandzki" lang="nl" hreflang="nl" data-title="Genisteïne" data-language-autonym="Nederlands" data-language-local-name="niderlandzki" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%B2%E3%83%8B%E3%82%B9%E3%83%86%E3%82%A4%E3%83%B3" title="ゲニステイン – japoński" lang="ja" hreflang="ja" data-title="ゲニステイン" data-language-autonym="日本語" data-language-local-name="japoński" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Geniste%C3%ADna" title="Genisteína – portugalski" lang="pt" hreflang="pt" data-title="Genisteína" data-language-autonym="Português" data-language-local-name="portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Genistein%C4%83" title="Genisteină – rumuński" lang="ro" hreflang="ro" data-title="Genisteină" data-language-autonym="Română" data-language-local-name="rumuński" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B5%D0%BD%D0%B8%D1%81%D1%82%D0%B5%D0%B8%D0%BD" title="Генистеин – rosyjski" lang="ru" hreflang="ru" data-title="Генистеин" data-language-autonym="Русский" data-language-local-name="rosyjski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Genistein" title="Genistein – serbski" lang="sr" hreflang="sr" data-title="Genistein" data-language-autonym="Српски / srpski" data-language-local-name="serbski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Genistein" title="Genistein – serbsko-chorwacki" lang="sh" hreflang="sh" data-title="Genistein" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbsko-chorwacki" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Genisteiini" title="Genisteiini – fiński" lang="fi" hreflang="fi" data-title="Genisteiini" data-language-autonym="Suomi" data-language-local-name="fiński" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Genistein" title="Genistein – turecki" lang="tr" hreflang="tr" data-title="Genistein" data-language-autonym="Türkçe" data-language-local-name="turecki" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D0%B5%D0%BD%D1%96%D1%81%D1%82%D0%B5%D1%97%D0%BD" title="Геністеїн – ukraiński" lang="uk" hreflang="uk" data-title="Геністеїн" data-language-autonym="Українська" data-language-local-name="ukraiński" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E6%9F%93%E6%96%99%E6%9C%A8%E7%B4%A0" title="染料木素 – chiński" lang="zh" hreflang="zh" data-title="染料木素" data-language-autonym="中文" data-language-local-name="chiński" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q415957#sitelinks-wikipedia" title="Edytuj linki pomiędzy wersjami językowymi" class="wbc-editpage">Edytuj linki</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Przestrzenie nazw"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Genisteina" title="Zobacz stronę treści [c]" accesskey="c"><span>Artykuł</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Dyskusja:Genisteina" rel="discussion" title="Dyskusja o zawartości tej strony [t]" accesskey="t"><span>Dyskusja</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Zmień wariant języka" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">polski</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Widok"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Genisteina"><span>Czytaj</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Genisteina&veaction=edit" title="Edytuj tę stronę [v]" accesskey="v"><span>Edytuj</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Genisteina&action=edit" title="Edycja kodu źródłowego strony [e]" accesskey="e"><span>Edytuj kod źródłowy</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Genisteina&action=history" title="Starsze wersje tej strony [h]" accesskey="h"><span>Wyświetl historię</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Narzędzia dla stron"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Narzędzia" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Narzędzia</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Narzędzia</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">przypnij</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">ukryj</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Więcej opcji" > <div class="vector-menu-heading"> Działania </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Genisteina"><span>Czytaj</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Genisteina&veaction=edit" title="Edytuj tę stronę [v]" accesskey="v"><span>Edytuj</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Genisteina&action=edit" title="Edycja kodu źródłowego strony [e]" accesskey="e"><span>Edytuj kod źródłowy</span></a></li><li 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plik</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Specjalna:Strony_specjalne" title="Lista wszystkich stron specjalnych [q]" accesskey="q"><span>Strony specjalne</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Genisteina&oldid=73256216" title="Stały link do tej wersji tej strony"><span>Link do tej wersji</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Genisteina&action=info" title="Więcej informacji na temat tej strony"><span>Informacje o tej stronie</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Specjalna:Cytuj&page=Genisteina&id=73256216&wpFormIdentifier=titleform" title="Informacja o tym jak należy cytować tę stronę"><span>Cytowanie tego artykułu</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Specjalna:Skr%C3%B3%C4%87_adres_URL&url=https%3A%2F%2Fpl.wikipedia.org%2Fwiki%2FGenisteina"><span>Zobacz skrócony adres 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<div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Z Wikipedii, wolnej encyklopedii</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="pl" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r75123796">.mw-parser-output .chemiczny-infobox .ibox-inner>tbody>tr>th[colspan],.mw-parser-output .chemiczny-infobox>tbody>tr>th[colspan],.mw-parser-output .chemiczny-infobox .chem-head,.mw-parser-output .chemiczny-infobox .chemia-aktywny-head,.mw-parser-output .chemiczny-infobox>caption{background-color:#ffeece;color:black}.mw-parser-output .chemiczny-infobox .chemia-aktywny-head,.mw-parser-output .chemiczny-infobox .chem-head{font-weight:bold;text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .chemiczny-infobox .chem-head,html.skin-theme-clientpref-night .mw-parser-output .chemiczny-infobox .chemia-aktywny-head,html.skin-theme-clientpref-night .mw-parser-output .chemiczny-infobox caption{filter:brightness(0.85)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .chemiczny-infobox .chem-head,html.skin-theme-clientpref-os .mw-parser-output .chemiczny-infobox .chemia-aktywny-head,html.skin-theme-clientpref-os .mw-parser-output .chemiczny-infobox caption{filter:brightness(0.85)}}</style> <table class="infobox chemiczny-infobox" cellpadding="4"> <caption class="naglowek notheme"><style data-mw-deduplicate="TemplateStyles:r65781301">.mw-parser-output .infobox>caption>.iboxt-flex{display:flex;justify-content:flex-start;align-items:center;gap:4px}.mw-parser-output .infobox>caption>.iboxt-flex>.iboxt-ikona{flex-grow:0;flex-shrink:0;font-size:7px;max-width:40px;overflow:hidden}.mw-parser-output .infobox>caption>.iboxt-flex>.iboxt-tekst{flex-grow:1}.mw-parser-output .infobox>caption .iboxt-1{font-weight:bold}.mw-parser-output .infobox>caption .iboxt-2{font-style:italic}.mw-parser-output .infobox>caption .iboxt-3{font-style:italic;font-size:90%}</style><div class="iboxt-1">Genisteina</div> </caption> <tbody><tr class="grafika iboxs"> <td colspan="2" style="padding:0;"> <table class="ibox2"> <tbody><tr> <td style="text-align: center; vertical-align:middle;"><span class="skin-invert-image" typeof="mw:File"><a href="/wiki/Plik:Genistein.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Genistein.svg/240px-Genistein.svg.png" decoding="async" width="240" height="113" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Genistein.svg/360px-Genistein.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Genistein.svg/480px-Genistein.svg.png 2x" data-file-width="512" data-file-height="242" /></a></span> </td></tr> </tbody></table> </td></tr> <tr> <td colspan="2" style="padding:0;"> <table class="collapsible collapsed ibox-inner"> <tbody><tr> <th colspan="2" class="chem-head notheme" style="border-top:0px;">Nazewnictwo </th></tr> <tr> <td colspan="2" style="border-top:1px solid #aaa; spacing:0px; padding:0px; height:0px;"> </td></tr> <tr> <td colspan="2" style="background:var(--background-color-neutral, #eaecf0); color:inherit; text-align:left; font-weight:normal;">Nomenklatura systematyczna (<a href="/wiki/Mi%C4%99dzynarodowa_Unia_Chemii_Czystej_i_Stosowanej" title="Międzynarodowa Unia Chemii Czystej i Stosowanej">IUPAC</a>) </td></tr> <tr> <td colspan="2" style="text-align:center;"><div style="max-width: 240px; word-wrap: break-word;">4′,5,7-trihydroksyizoflawon</div> </td></tr> <tr> <td colspan="2" style="color:inherit; background:var(--background-color-neutral, #eaecf0); text-align:left; font-weight:normal; border-top:1px var(--border-color-base, #a2a9b1) dashed">Inne nazwy i oznaczenia </td></tr> <tr> <td colspan="2" style="text-align:center;">5,7-dihydroksy-3-(4-hydroksyfenylo)chromen-4-on </td></tr> </tbody></table> </td></tr> <tr> <td colspan="2" class="chem-head notheme" style="border-bottom:1px solid var(--border-color-base, #a2a9b1); border-top:1px solid var(--border-color-base, #a2a9b1);">Ogólne informacje </td></tr> <tr> <th>Wzór sumaryczny </th> <td> <p>C<sub>15</sub>H<sub>10</sub>O<sub>5</sub> </p> </td></tr> <tr> <th><a href="/wiki/Masa_molowa" title="Masa molowa">Masa molowa</a> </th> <td> <p>270,24 g/mol </p> </td></tr> <tr> <th>Wygląd </th> <td> <p>jasnożółty proszek<sup id="cite_ref-SA_1-0" class="reference"><a href="#cite_note-SA-1">[1]</a></sup> </p> </td></tr> <tr> <td colspan="2" class="chem-head notheme" style="border-bottom:1px solid var(--border-color-base, #a2a9b1); border-top:1px solid var(--border-color-base, #a2a9b1);">Identyfikacja </td></tr> <tr> <th><a href="/wiki/Numer_CAS" title="Numer CAS">Numer CAS</a> </th> <td> <p><a class="external text" href="https://tools.wmflabs.org/magnustools/cas.php?language=pl&cas=446-72-0">446-72-0</a> </p> </td></tr> <tr> <th><a href="/wiki/PubChem" title="PubChem">PubChem</a> </th> <td> <p><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/compound/5280961">5280961</a> </p> </td></tr> <tr> <th><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a> </th> <td> <p><a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB01645">DB01645</a> </p> </td></tr> <tr> <td colspan="2" style="padding:0;"> <table class="collapsible collapsed"> <tbody><tr> <th colspan="2" style="background:var(--background-color-neutral, #eaecf0); color:inherit; text-align:left; font-weight:normal; border-top:1px var(--border-color-base, #a2a9b1) dashed;"><a href="/wiki/SMILES" title="SMILES">SMILES</a> </th></tr> <tr> <td colspan="2" style="text-align:left; font-size:90%; padding:auto 0px auto 0px;"><div style="width: 240px; word-break: break-all;">C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O</div> </td></tr> </tbody></table> </td></tr> <tr> <td colspan="2" style="padding:0;"> <table class="collapsible collapsed"> <tbody><tr> <th colspan="2" style="background:var(--background-color-neutral, #eaecf0); color:inherit; text-align:left; font-weight:normal; border-top:1px var(--border-color-base, #a2a9b1) dashed;"><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a> </th></tr> <tr> <td colspan="2" style="text-align:left; font-size:90%; padding:auto 0px auto 0px;"><div style="width: 240px; word-break: break-all;">InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H</div> </td></tr> <tr style="background:var(--background-color-neutral, #eaecf0); color:inherit;"> <td colspan="2">InChIKey </td></tr> <tr> <td colspan="2" style="text-align:left; font-size:90%; padding:auto 0px auto 0px;"><div style="width: 240px; word-break: break-all;">TZBJGXHYKVUXJN-UHFFFAOYSA-N</div> </td></tr> </tbody></table> </td></tr> <tr> <td colspan="2" style="padding:0;"> <table class="collapsible collapsed ibox-inner"> <tbody><tr style="border-top:1px solid var(--border-color-base, #a2a9b1);"> <th colspan="2" class="chem-head notheme" style="border-top:1px solid var(--border-color-base, #a2a9b1);">Właściwości </th></tr> <tr> <td colspan="2" style="border-top:1px solid #aaa; spacing:0px; padding:0px; height:0px;"> </td></tr> <tr style="color:inherit; background-color:var(--background-color-neutral, #eaecf0)"> <td colspan="2"><a href="/wiki/Rozpuszczalno%C5%9B%C4%87" title="Rozpuszczalność">Rozpuszczalność</a> </td></tr> <tr> <td colspan="2">rozpuszczalna w <a href="/wiki/Dimetylosulfotlenek" title="Dimetylosulfotlenek">DMSO</a> i <a href="/wiki/Etanol" title="Etanol">etanolu</a><sup id="cite_ref-SA_1-1" class="reference"><a href="#cite_note-SA-1">[1]</a></sup> </td></tr> <tr> <td colspan="2" style="border-top:1px dashed #aaa; spacing:0px; padding:0px; height:0px;"> </td></tr> <tr> <th><a href="/wiki/Dysocjacja_termiczna" title="Dysocjacja termiczna">Temperatura rozkładu</a> </th> <td> <p>297–301,5 °C<sup id="cite_ref-CID_2-0" class="reference"><a href="#cite_note-CID-2">[2]</a></sup><sup id="cite_ref-DB_3-0" class="reference"><a href="#cite_note-DB-3">[3]</a></sup> </p> </td></tr> <tr> <th><a href="/wiki/Wsp%C3%B3%C5%82czynnik_podzia%C5%82u" title="Współczynnik podziału">logP</a> </th> <td> <p>2,84 </p> </td></tr> <tr> <th><a href="/wiki/Moc_kwasu" title="Moc kwasu">Kwasowość</a> (pK<sub>a</sub>) </th> <td> <p>7,08 </p> </td></tr> </tbody></table> </td></tr> <tr> <td colspan="2" style="padding:0;"> <table class="collapsible collapsed ibox-inner"> <tbody><tr style="border-top:1px solid var(--border-color-base, #a2a9b1);"> <th colspan="2" class="chem-head notheme" style="border-top:1px solid var(--border-color-base, #a2a9b1);">Niebezpieczeństwa </th></tr> <tr style="border-top:1px solid var(--border-color-base, #a2a9b1); color:inherit; background:var(--background-color-base, #fff)"> <td colspan="2"><a href="/wiki/Karta_charakterystyki" title="Karta charakterystyki">Karta charakterystyki</a>: <a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/PL/pl/sds/sigma/g6776">dane zewnętrzne</a> firmy Sigma-Aldrich [dostęp 2018-12-01] </td></tr> <tr> <td colspan="2" style="color:black; background-color:#FFEECE; border-bottom:1px var(--border-color-base, #a2a9b1) solid; border-top:1px var(--border-color-base, #a2a9b1) solid"> </td></tr> <tr> <td colspan="2" style="color:inherit; background:var(--background-color-base, #fff); border-top:1px var(--border-color-base, #a2a9b1) solid; font-weight:bold; text-align:center; border-bottom:1px var(--border-color-base, #a2a9b1) solid"><a href="/wiki/Globalnie_zharmonizowany_system_klasyfikacji_i_oznakowania_chemikali%C3%B3w" title="Globalnie zharmonizowany system klasyfikacji i oznakowania chemikaliów">Globalnie zharmonizowany system<br />klasyfikacji i oznakowania chemikaliów</a> </td></tr> <tr style="text-align:center; font-size:90%; color:inherit; background:var(--background-color-base, #fff);"> <td colspan="2">Na podstawie podanej karty charakterystyki </td></tr> <tr style="text-align:center; font-size:90%; color:inherit; background:var(--background-color-base, #fff);"> <td colspan="2"><div class="nopadding" style="margin:0 auto; width:100%;"> <table style="text-align:center; margin-left:auto; margin-right:auto; color:black; background:transparent;" class="nogrid" cellpadding="0"> <tbody><tr> <td><span typeof="mw:File"><a href="/wiki/Piktogramy_wskazuj%C4%85ce_rodzaj_zagro%C5%BCenia" title="Wykrzyknik"><img alt="Wykrzyknik" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/45px-GHS-pictogram-exclam.svg.png" decoding="async" width="45" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/68px-GHS-pictogram-exclam.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/90px-GHS-pictogram-exclam.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span> </td></tr> </tbody></table><b>Uwaga</b></div> </td></tr> <tr> <td colspan="2" style="border-top:1px dashed var(--border-color-base, #a2a9b1); spacing:0px; padding:0px; height:0px;"> </td></tr> <tr> <th><a href="/wiki/Zwroty_wskazuj%C4%85ce_rodzaj_zagro%C5%BCenia" title="Zwroty wskazujące rodzaj zagrożenia">Zwroty H</a> </th> <td> <p><abbr style="color:blue; border-bottom:1px dotted blue; text-decoration:none" title="H302: Działa szkodliwie po połknięciu.">H302</abbr> </p> </td></tr> <tr> <th><a href="/wiki/Zwroty_wskazuj%C4%85ce_%C5%9Brodki_ostro%C5%BCno%C5%9Bci" title="Zwroty wskazujące środki ostrożności">Zwroty P</a> </th> <td> <p><i>brak zwrotów P</i> </p> </td></tr> <tr> <td colspan="2" style="color:black; background-color:#FFEECE; border-bottom:1px var(--border-color-base, #a2a9b1) solid; border-top:1px var(--border-color-base, #a2a9b1) solid"> </td></tr> <tr> <th><a href="/wiki/Registry_of_Toxic_Effects_of_Chemical_Substances" title="Registry of Toxic Effects of Chemical Substances">Numer RTECS</a> </th> <td> <p>NR2392000 </p> </td></tr> </tbody></table> </td></tr> <tr> <td colspan="2" class="chem-head notheme" style="font-weight:normal; font-size:x-small; border-bottom:1px solid var(--border-color-base, #a2a9b1); border-top:1px solid var(--border-color-base, #a2a9b1);">Jeżeli nie podano inaczej, dane dotyczą<br /><a href="/wiki/Stan_standardowy" title="Stan standardowy">stanu standardowego</a> (25 °C, 1000 hPa) </td></tr> <tr> <td colspan="2" style="text-align:center; color:black; background-color:white; border-top:1px #aaa solid; height:12px;"> </td></tr> <tr> <td colspan="2" style="padding:0;"> <table class="collapsible collapsed ibox-inner"> <tbody><tr style="border-top: 1px solid #aaa"> <th colspan="2" class="chemia-aktywny-head notheme" style="border-top:1px solid #aaa;">Farmakokinetyka </th></tr> <tr> <td colspan="2" style="border-top:1px solid #aaa; spacing:0px; padding:0px; height:0px;"> </td></tr> <tr> <th>Działanie </th> <td> <p>przeciwnowotworowe </p> </td></tr> </tbody></table> </td></tr> <tr class="noprint plainlinks" style="border-top:1px solid var(--border-color-base, #a2a9b1); text-align:center;"> <td colspan="2" style="padding:0;"> <table cellpadding="4" cellspacing="0" style="width:100%; margin:0px; background:var(--background-color-base, #fff); color:inherit"> <tbody><tr> <td style="vertical-align:middle; width:30px;"><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/Category:Genistein" title="Commons"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/21px-Commons-logo.svg.png" decoding="async" width="21" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/31px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/42px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> </td> <td style="vertical-align:middle;"><a href="https://commons.wikimedia.org/wiki/Category:Genistein" class="extiw" title="commons:Category:Genistein">Multimedia w Wikimedia Commons</a> </td></tr></tbody></table> </td></tr> </tbody></table> <p><b>Genisteina</b> – <a href="/wiki/Zwi%C4%85zki_organiczne" title="Związki organiczne">organiczny związek chemiczny</a> z grupy <a href="/wiki/Flawonoidy" title="Flawonoidy">flawonoidów</a> (dokładniej izoflawonów). Występuje w roślinach z rodziny <a href="/wiki/Bobowate" title="Bobowate">bobowatych</a>, w tym w ziarnie <a href="/wiki/Soja" title="Soja">soi</a> (<i>Soiae semen</i>). W roślinach występuje w postaci wolnej (jako <a href="/wiki/Aglikon" title="Aglikon">aglikon</a>) lub <a href="/wiki/Wi%C4%85zanie_O-glikozydowe" title="Wiązanie O-glikozydowe">związana glikozydowo</a> (<a href="/w/index.php?title=Genistyna&action=edit&redlink=1" class="new" title="Genistyna (strona nie istnieje)">genistyna</a>). </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Działanie_przeciwrobacze"><span id="Dzia.C5.82anie_przeciwrobacze"></span>Działanie przeciwrobacze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Genisteina&veaction=edit&section=1" title="Edytuj sekcję: Działanie przeciwrobacze" class="mw-editsection-visualeditor"><span>edytuj</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Genisteina&action=edit&section=1" title="Edytuj kod źródłowy sekcji: Działanie przeciwrobacze"><span>edytuj kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tradycyjnym środkiem zwalczającym pasożyty używanym przez plemiona <a href="/wiki/Indie" title="Indie">indyjskie</a> jest wyciąg z <a href="/wiki/Kora" title="Kora">kory</a> <a href="/wiki/Bulwa_(botanika)" title="Bulwa (botanika)">bulwy</a> <a href="/wiki/Ro%C5%9Bliny_str%C4%85czkowe" title="Rośliny strączkowe">rośliny strączkowej</a> <i><a href="/w/index.php?title=Felmingia_vestita&action=edit&redlink=1" class="new" title="Felmingia vestita (strona nie istnieje)">Felmingia vestita</a></i>, w którym za przeciwrobacze właściwości odpowiada genisteina<sup id="cite_ref-Tandon-1997_4-0" class="reference"><a href="#cite_note-Tandon-1997-4">[4]</a></sup>. Badania potwierdziły skuteczność tego preparatu przeciwko niektórym <a href="/wiki/Przywry_digeniczne" title="Przywry digeniczne">przywrom</a> (np. <a href="/wiki/Motylica_w%C4%85trobowa" title="Motylica wątrobowa">motylicy wątrobowej</a><sup id="cite_ref-Toner-2008_5-0" class="reference"><a href="#cite_note-Toner-2008-5">[5]</a></sup> i <i><a href="/wiki/Fasciolopsis_buski" title="Fasciolopsis buski">Fasciolopsis buski</a><sup id="cite_ref-Kar-2002_6-0" class="reference"><a href="#cite_note-Kar-2002-6">[6]</a></sup></i>) oraz <a href="/wiki/Tasiemce" title="Tasiemce">tasiemcowi</a> <i><a href="/w/index.php?title=Raillietina_echinobothrida&action=edit&redlink=1" class="new" title="Raillietina echinobothrida (strona nie istnieje)">Raillietina echinobothrida</a></i><sup id="cite_ref-Kar-2002_6-1" class="reference"><a href="#cite_note-Kar-2002-6">[6]</a></sup>. Wykazane zostało także działanie toksyczne genisteiny oraz jej pochodnych (<i>Rm6423</i> i <i>Rm6426</i>) wobec <a href="/wiki/Tasiemiec_b%C4%85blowcowy" title="Tasiemiec bąblowcowy">tasiemca bąblowcowego</a> i <a href="/wiki/B%C4%85blowiec_wielojamowy" title="Bąblowiec wielojamowy">bąblowca wielojamowego</a><sup id="cite_ref-Naguleswaran-2006_7-0" class="reference"><a href="#cite_note-Naguleswaran-2006-7">[7]</a></sup>. Działanie przeciwrobacze genisteiny związane jest z hamowaniem <a href="/wiki/Glikoliza" title="Glikoliza">glikolizy</a> i <a href="/wiki/Glikogenoliza" title="Glikogenoliza">glikogenolizy</a><sup id="cite_ref-Das-2004_8-0" class="reference"><a href="#cite_note-Das-2004-8">[8]</a></sup> oraz zaburzaniu sygnalizacji zależnej od jonów <span style="white-space:nowrap">Ca<span style="display:inline-block; margin-bottom:-0.3em; vertical-align:0.7em; line-height:1.0em; font-size:80%; text-align:left;">2+<br /></span></span> oraz poziomu <a href="/wiki/Tlenek_azotu" title="Tlenek azotu">NO</a> w <a href="/wiki/Paso%C5%BCyt_wewn%C4%99trzny" title="Pasożyt wewnętrzny">pasożytach</a><sup id="cite_ref-Das-2006_9-0" class="reference"><a href="#cite_note-Das-2006-9">[9]</a></sup><sup id="cite_ref-Das-2009_10-0" class="reference"><a href="#cite_note-Das-2009-10">[10]</a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Działanie_na_komórki_ludzkie"><span id="Dzia.C5.82anie_na_kom.C3.B3rki_ludzkie"></span>Działanie na komórki ludzkie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Genisteina&veaction=edit&section=2" title="Edytuj sekcję: Działanie na komórki ludzkie" class="mw-editsection-visualeditor"><span>edytuj</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Genisteina&action=edit&section=2" title="Edytuj kod źródłowy sekcji: Działanie na komórki ludzkie"><span>edytuj kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Genisteina ma właściwości <a href="/wiki/Leki_cytostatyczne" title="Leki cytostatyczne">cytostatyczne</a> i <a href="/wiki/Cytotoksyczno%C5%9B%C4%87" title="Cytotoksyczność">cytotoksyczne</a> wobec komórek, zarówno zdrowych, jak i <a href="/wiki/Kom%C3%B3rka_nowotworowa" title="Komórka nowotworowa">nowotworowych</a>. Mechanizmów tych działań dopatruje się w hamowaniu aktywności <a href="/wiki/Kinazy" title="Kinazy">kinaz</a> <a href="/wiki/Tyrozyna" title="Tyrozyna">tyrozynowych</a> przekazujących sygnały do wzrostu komórek oraz <a href="/wiki/Topoizomerazy" title="Topoizomerazy">topoizomerazy II</a> – <a href="/wiki/Bia%C5%82ka" title="Białka">białka</a> odpowiedzialnego za stabilność <a href="/wiki/Kwas_deoksyrybonukleinowy" title="Kwas deoksyrybonukleinowy">DNA</a><sup id="cite_ref-Morris-2003_11-0" class="reference"><a href="#cite_note-Morris-2003-11">[11]</a></sup>. Może kierować w ten sposób komórki na <a href="/wiki/Apoptoza" title="Apoptoza">szlak apoptotyczny</a>. Właściwość ta może być uznana za korzystną w przypadku leczenia chorób nowotworowych. Z drugiej strony jej działanie może być szkodliwe dla komórek zdrowych. Tak jak inne <a href="/wiki/Flawonoidy" title="Flawonoidy">flawonoidy</a> wpływające na topoizomerazy, może działać <a href="/wiki/Mutagen" title="Mutagen">mutagennie</a>, np. powoduje pęknięcia DNA w genie <i>MLL</i>, którego <a href="/wiki/Mutacja" title="Mutacja">mutacje</a> są częste w ostrych białaczkach<sup id="cite_ref-Thirman-1993_12-0" class="reference"><a href="#cite_note-Thirman-1993-12">[12]</a></sup><sup id="cite_ref-Strick-2000_13-0" class="reference"><a href="#cite_note-Strick-2000-13">[13]</a></sup>. Takie działanie wykazano w <a href="/wiki/Kom%C3%B3rki_macierzyste" title="Komórki macierzyste">komórkach macierzystych</a> krwi traktowanych flavonoidami <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a>.</i><sup id="cite_ref-Janssen-2007_14-0" class="reference"><a href="#cite_note-Janssen-2007-14">[14]</a></sup> Wysoki poziom flawonoidów w diecie kobiet ciężarnych jest podejrzewany o zwiększanie ryzyka wystąpienia u niemowląt <a href="/wiki/Ostra_bia%C5%82aczka_szpikowa" title="Ostra białaczka szpikowa">ostrych białaczek szpikowych</a> (AML) stanowiących ok. 15% z całkowitej zachorowalności niemowląt na białaczki (34/milion urodzeń w <a href="/wiki/Stany_Zjednoczone" title="Stany Zjednoczone">USA</a>)<sup id="cite_ref-Ross-1998_15-0" class="reference"><a href="#cite_note-Ross-1998-15">[15]</a></sup><sup id="cite_ref-Ross-2000_16-0" class="reference"><a href="#cite_note-Ross-2000-16">[16]</a></sup><sup id="cite_ref-Spector-2005_17-0" class="reference"><a href="#cite_note-Spector-2005-17">[17]</a></sup>. Dziewczynki karmione w niemowlęctwie mlekiem sojowym (zawierającym genisteinę) częściej mają <a href="/wiki/B%C3%B3le_menstruacyjne" title="Bóle menstruacyjne">bolesne miesiączki</a> jako młode dorosłe<sup id="cite_ref-Upson_18-0" class="reference"><a href="#cite_note-Upson-18">[18]</a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Zespół_Sanfilippo"><span id="Zesp.C3.B3.C5.82_Sanfilippo"></span>Zespół Sanfilippo</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Genisteina&veaction=edit&section=3" title="Edytuj sekcję: Zespół Sanfilippo" class="mw-editsection-visualeditor"><span>edytuj</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Genisteina&action=edit&section=3" title="Edytuj kod źródłowy sekcji: Zespół Sanfilippo"><span>edytuj kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Z badań wykonanych w zespole <a href="/wiki/Grzegorz_W%C4%99grzyn" title="Grzegorz Węgrzyn">Grzegorza Węgrzyna</a> (Katedra Biologii Molekularnej <a href="/wiki/Uniwersytet_Gda%C5%84ski" title="Uniwersytet Gdański">Uniwersytetu Gdańskiego</a>) wynika, że genisteina powoduje zmniejszenie kumulowania <a href="/wiki/Glikozoaminoglikany" title="Glikozoaminoglikany">glikozoaminoglikanów</a>, których rozkład jest zaburzony w <a href="/wiki/Zesp%C3%B3%C5%82_Sanfilippo" title="Zespół Sanfilippo">chorobie Sanfilippo</a>. Z badań <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i>, na zwierzętach oraz <a href="/wiki/Eksperyment_kliniczny" title="Eksperyment kliniczny">badań klinicznych</a> wynika, że postęp tej choroby może być znacznie spowolniony lub zahamowany przez stosowanie odpowiedniej dawki genisteiny<sup id="cite_ref-Piotrowska_19-0" class="reference"><a href="#cite_note-Piotrowska-19">[19]</a></sup><sup id="cite_ref-Koton_20-0" class="reference"><a href="#cite_note-Koton-20">[20]</a></sup><sup id="cite_ref-Wegrzyn_21-0" class="reference"><a href="#cite_note-Wegrzyn-21">[21]</a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Działanie_hormonopodobne"><span id="Dzia.C5.82anie_hormonopodobne"></span>Działanie hormonopodobne</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Genisteina&veaction=edit&section=4" title="Edytuj sekcję: Działanie hormonopodobne" class="mw-editsection-visualeditor"><span>edytuj</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Genisteina&action=edit&section=4" title="Edytuj kod źródłowy sekcji: Działanie hormonopodobne"><span>edytuj kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><span class="need_ref" style="text-decoration: underline dotted grey;" title="Te informacje wymagają podania przypisów bibliograficznych od 2024-03">Genisteina należy do <a href="/wiki/Fitoestrogeny" title="Fitoestrogeny">fitoestrogenów</a> – wykazuje powinowactwo do <a href="/w/index.php?title=Receptory_beta-estrogenowe&action=edit&redlink=1" class="new" title="Receptory beta-estrogenowe (strona nie istnieje)">receptorów beta-estrogenowych</a> i może je pobudzać (działanie <a href="/wiki/Agonista" title="Agonista">agonistyczne</a>) lub hamować (działanie <a href="/wiki/Antagonista_(farmakologia)" title="Antagonista (farmakologia)">antagonistyczne</a>). Właściwości te mają znaczenie w prewencji <a href="/wiki/Rak_sutka" title="Rak sutka">nowotworów piersi</a> u kobiet i <a href="/wiki/Rak_gruczo%C5%82u_krokowego" title="Rak gruczołu krokowego">gruczołu krokowego</a> u mężczyzn.</span><sup class="noprint" title="Te informacje wymagają podania przypisów bibliograficznych od 2024-03">[<a href="/wiki/Pomoc:Przypisy" title="Pomoc:Przypisy">potrzebny przypis</a>]</sup> </p><p>Na podstawie badań <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i> oraz <i><a href="/wiki/In_vivo" title="In vivo">in vivo</a></i> stwierdzono, że genisteina może także przyśpieszać wzrost niektórych rodzajów raka piersi<sup id="cite_ref-Yang2010_22-0" class="reference"><a href="#cite_note-Yang2010-22">[22]</a></sup> oraz zmniejszać ich wrażliwość na <a href="/wiki/Tamoksyfen" title="Tamoksyfen">tamoksifen</a> oraz <a href="/wiki/Letrozol" title="Letrozol">letrozol</a> – podstawowe leki stosowane w terapii tych nowotworów<sup id="cite_ref-Helferich-2008_23-0" class="reference"><a href="#cite_note-Helferich-2008-23">[23]</a></sup><sup id="cite_ref-Tonetti-2007_24-0" class="reference"><a href="#cite_note-Tonetti-2007-24">[24]</a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Przypisy">Przypisy</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Genisteina&veaction=edit&section=5" title="Edytuj sekcję: Przypisy" class="mw-editsection-visualeditor"><span>edytuj</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Genisteina&action=edit&section=5" title="Edytuj kod źródłowy sekcji: Przypisy"><span>edytuj kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="do-not-make-smaller refsection"><div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-SA-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-SA_1-0">a</a></sup> <sup><a href="#cite_ref-SA_1-1">b</a></sup></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/PL/pl/sds/sigma/g6776">Genistein (nr G6776)</a> – karta charakterystyki produktu Sigma-Aldrich (<a href="/wiki/Merck_(niemieckie_przedsi%C4%99biorstwo)" title="Merck (niemieckie przedsiębiorstwo)">Merck</a>) na obszar Polski. [dostęp 2018-12-01]. <small>(<a href="/wiki/Wikiprojekt:Chemia/Problemy_z_kartami_charakterystyki_Sigma-Aldrich" title="Wikiprojekt:Chemia/Problemy z kartami charakterystyki Sigma-Aldrich">przeczytaj, jeśli nie wyświetla się prawidłowa wersja karty charakterystyki</a>)</small></span> </li> <li id="cite_note-CID-2"><span class="mw-cite-backlink"><a href="#cite_ref-CID_2-0">↑</a></span> <span class="reference-text"><cite class="citation web open-access"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0000446720"><i>Genistein</i></a>, [w:] ChemIDplus [online], <a href="/wiki/National_Library_of_Medicine" title="National Library of Medicine">United States National Library of Medicine</a><span class="accessdate"> [dostęp 2012-09-01]</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=unknown&rft.atitle=Genistein&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.jtitle=%5B%5BNational+Library+of+Medicine%7CUnited+States+National+Library+of+Medicine%5D%5D&rft_id=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fsubstance%2F%3Fsource%3Dchemidplus%26sourceid%3D0000446720" style="display:none"> </span> <span class="lang-list">(<abbr title="Treść w języku angielskim (English)">ang.</abbr>)</span>.</cite></span> </li> <li id="cite_note-DB-3"><span class="mw-cite-backlink"><a href="#cite_ref-DB_3-0">↑</a></span> <span class="reference-text"><cite class="citation web open-access"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB01645"><i>Genistein</i></a>, [w:] <a href="/wiki/DrugBank" title="DrugBank">DrugBank</a> [online], <a href="/wiki/Uniwersytet_Alberty" title="Uniwersytet Alberty">University of Alberta</a>, DB01645<span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=unknown&rft.atitle=Genistein&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.jtitle=%5B%5BUniwersytet+Alberty%7CUniversity+of+Alberta%5D%5D&rft_id=https%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB01645" style="display:none"> </span> <span class="lang-list">(<abbr title="Treść w języku angielskim (English)">ang.</abbr>)</span>.</cite></span> </li> <li id="cite_note-Tandon-1997-4"><span class="mw-cite-backlink"><a href="#cite_ref-Tandon-1997_4-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">V.</span><span class="cite-name-initials" style="display:none">V.</span> </span><span class="cite-lastname">Tandon</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">V.</span><span class="cite-name-initials">V.</span></span><span class="cite-at-al" title="V. Tandon, P. Pal, B. Roy, H.S. Rao, K.S. Reddy"> i inni</span>, <i>In vitro anthelmintic activity of root-tuber extract of Flemingia vestita, an indigenous plant in Shillong, India</i>, „Parasitology Research”, 83 (5), 1997, s. 492–498, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1007%2Fs004360050286">10.1007/s004360050286</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9197399">9197399</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=1997&rft.atitle=In+vitro+anthelmintic+activity+of+root-tuber+extract+of+Flemingia+vestita%2C+an+indigenous+plant+in+Shillong%2C+India&rft.jtitle=Parasitology+Research&rft.volume=83&rft.edition=5&rft_id=info%3Apmid%2F9197399&rft_id=info%3Adoi%2F10.1007%2Fs004360050286" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Toner-2008-5"><span class="mw-cite-backlink"><a href="#cite_ref-Toner-2008_5-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">E.</span><span class="cite-name-initials" style="display:none">E.</span> </span><span class="cite-lastname">Toner</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">E.</span><span class="cite-name-initials">E.</span></span><span class="cite-at-al" title="E. Toner, G.P. Brennan, K. Wells, J.G. McGeown, I. Fairweather"> i inni</span>, <i>Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica</i>, „Parasitology”, 135 (10), 2008, s. 1189–1203, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1017%2FS0031182008004630">10.1017/S0031182008004630</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18771609">18771609</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2008&rft.atitle=Physiological+and+morphological+effects+of+genistein+against+the+liver+fluke%2C+Fasciola+hepatica&rft.jtitle=Parasitology&rft.volume=135&rft.edition=10&rft_id=info%3Apmid%2F18771609&rft_id=info%3Adoi%2F10.1017%2FS0031182008004630" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Kar-2002-6"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Kar-2002_6-0">a</a></sup> <sup><a href="#cite_ref-Kar-2002_6-1">b</a></sup></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Pradip K.</span><span class="cite-name-initials" title="Pradip K." style="display:none">P.K.</span> </span><span class="cite-lastname">Kar</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Pradip K.</span><span class="cite-name-initials" title="Pradip K.">P.K.</span></span>, <span class="cite-name-before"><span class="cite-name-full">Veena</span><span class="cite-name-initials" title="Veena" style="display:none">V.</span> </span><span class="cite-lastname">Tandon</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Veena</span><span class="cite-name-initials" title="Veena">V.</span></span>, <span class="cite-name-before"><span class="cite-name-full">Nirmalendu</span><span class="cite-name-initials" title="Nirmalendu" style="display:none">N.</span> </span><span class="cite-lastname">Saha</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Nirmalendu</span><span class="cite-name-initials" title="Nirmalendu">N.</span></span>, <i>Anthelmintic efficacy of Flemingia vestita: genistein-induced effect on the activity of nitric oxide synthase and nitric oxide in the trematode parasite, Fasciolopsis buski</i>, „Parasitology International”, 51 (3), 2002, s. 249–257, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2FS1383-5769%2802%2900032-6">10.1016/S1383-5769(02)00032-6</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12243779">12243779</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2002&rft.atitle=Anthelmintic+efficacy+of+Flemingia+vestita%3A+genistein-induced+effect+on+the+activity+of+nitric+oxide+synthase+and+nitric+oxide+in+the+trematode+parasite%2C+Fasciolopsis+buski&rft.jtitle=Parasitology+International&rft.volume=51&rft.edition=3&rft_id=info%3Apmid%2F12243779&rft_id=info%3Adoi%2F10.1016%2FS1383-5769%2802%2900032-6" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Naguleswaran-2006-7"><span class="mw-cite-backlink"><a href="#cite_ref-Naguleswaran-2006_7-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid pmc nourl"><span class="cite-name-before"><span class="cite-name-full">Arunasalam</span><span class="cite-name-initials" title="Arunasalam" style="display:none">A.</span> </span><span class="cite-lastname">Naguleswaran</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Arunasalam</span><span class="cite-name-initials" title="Arunasalam">A.</span></span><span class="cite-at-al" title="Arunasalam Naguleswaran, Martin Spicher, Nathalie Vonlaufen, Luis M. Ortega-Mora, Paul Torgerson"> i inni</span>, <i>In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus</i>, „Antimicrobial Agents and Chemotherapy”, 50 (11), 2006, s. 3770–3778, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1128%2FAAC.00578-06">10.1128/AAC.00578-06</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16954323">16954323</a>, <a href="/wiki/PMCID" title="PMCID">PMCID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635224/">PMC1635224</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2006&rft.atitle=In+vitro+metacestodicidal+activities+of+genistein+and+other+isoflavones+against+Echinococcus+multilocularis+and+Echinococcus+granulosus&rft.jtitle=Antimicrobial+Agents+and+Chemotherapy&rft.volume=50&rft.edition=11&rft_id=info%3Apmid%2F16954323&rft_id=info%3Apmc%2F1635224&rft_id=info%3Adoi%2F10.1128%2FAAC.00578-06" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Das-2004-8"><span class="mw-cite-backlink"><a href="#cite_ref-Das-2004_8-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">B.</span><span class="cite-name-initials" style="display:none">B.</span> </span><span class="cite-lastname">Das</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">B.</span><span class="cite-name-initials">B.</span></span>, <span class="cite-name-before"><span class="cite-name-full">V.</span><span class="cite-name-initials" style="display:none">V.</span> </span><span class="cite-lastname">Tandon</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">V.</span><span class="cite-name-initials">V.</span></span>, <span class="cite-name-before"><span class="cite-name-full">N.</span><span class="cite-name-initials" style="display:none">N.</span> </span><span class="cite-lastname">Saha</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">N.</span><span class="cite-name-initials">N.</span></span>, <i>Anthelmintic efficacy of Flemingia vestita (Fabaceae): alteration in the activities of some glycolytic enzymes in the cestode, Raillietina echinobothrida</i>, „Parasitology Research”, 93 (4), 2004, s. 253–261, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1007%2Fs00436-004-1122-8">10.1007/s00436-004-1122-8</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15138892">15138892</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2004&rft.atitle=Anthelmintic+efficacy+of+Flemingia+vestita+%28Fabaceae%29%3A+alteration+in+the+activities+of+some+glycolytic+enzymes+in+the+cestode%2C+Raillietina+echinobothrida&rft.jtitle=Parasitology+Research&rft.volume=93&rft.edition=4&rft_id=info%3Apmid%2F15138892&rft_id=info%3Adoi%2F10.1007%2Fs00436-004-1122-8" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Das-2006-9"><span class="mw-cite-backlink"><a href="#cite_ref-Das-2006_9-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Bidyadhar</span><span class="cite-name-initials" title="Bidyadhar" style="display:none">B.</span> </span><span class="cite-lastname">Das</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Bidyadhar</span><span class="cite-name-initials" title="Bidyadhar">B.</span></span>, <span class="cite-name-before"><span class="cite-name-full">Veena</span><span class="cite-name-initials" title="Veena" style="display:none">V.</span> </span><span class="cite-lastname">Tandon</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Veena</span><span class="cite-name-initials" title="Veena">V.</span></span>, <span class="cite-name-before"><span class="cite-name-full">Nirmalendu</span><span class="cite-name-initials" title="Nirmalendu" style="display:none">N.</span> </span><span class="cite-lastname">Saha</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Nirmalendu</span><span class="cite-name-initials" title="Nirmalendu">N.</span></span>, <i>Effect of isoflavone from Flemingia vestita (Fabaceae) on the Ca<sup>2+</sup> homeostasis in Raillietina echinobothrida, the cestode of domestic fowl</i>, „Parasitology International”, 55 (1), 2006, s. 17–21, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.parint.2005.08.002">10.1016/j.parint.2005.08.002</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16198617">16198617</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2006&rft.atitle=Effect+of+isoflavone+from+Flemingia+vestita+%28Fabaceae%29+on+the+Ca%3Csup%3E2%2B%3C%2Fsup%3E+homeostasis+in+Raillietina+echinobothrida%2C+the+cestode+of+domestic+fowl&rft.jtitle=Parasitology+International&rft.volume=55&rft.edition=1&rft_id=info%3Apmid%2F16198617&rft_id=info%3Adoi%2F10.1016%2Fj.parint.2005.08.002" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Das-2009-10"><span class="mw-cite-backlink"><a href="#cite_ref-Das-2009_10-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Bidyadhar</span><span class="cite-name-initials" title="Bidyadhar" style="display:none">B.</span> </span><span class="cite-lastname">Das</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Bidyadhar</span><span class="cite-name-initials" title="Bidyadhar">B.</span></span><span class="cite-at-al" title="Bidyadhar Das, Veena Tandon, Larisha M. Lyndem, Alexander I. Gray, Valerie A. Ferro"> i inni</span>, <i>Phytochemicals from Flemingia vestita (Fabaceae) and Stephania glabra (Menispermeaceae) alter cGMP concentration in the cestode Raillietina echinobothrida</i>, „Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology”, 149 (3), 2009, s. 397–403, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.cbpc.2008.09.012">10.1016/j.cbpc.2008.09.012</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18854226">18854226</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2009&rft.atitle=Phytochemicals+from+Flemingia+vestita+%28Fabaceae%29+and+Stephania+glabra+%28Menispermeaceae%29+alter+cGMP+concentration+in+the+cestode+Raillietina+echinobothrida&rft.jtitle=Comparative+Biochemistry+and+Physiology+Part+C%3A+Toxicology+%26+Pharmacology&rft.volume=149&rft.edition=3&rft_id=info%3Apmid%2F18854226&rft_id=info%3Adoi%2F10.1016%2Fj.cbpc.2008.09.012" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Morris-2003-11"><span class="mw-cite-backlink"><a href="#cite_ref-Morris-2003_11-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">S.M.</span><span class="cite-name-initials" style="display:none">S.M.</span> </span><span class="cite-lastname">Morris</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">S.M.</span><span class="cite-name-initials">S.M.</span></span><span class="cite-at-al" title="S.M. Morris, G.S. Akerman, A.R. Warbritton, R.E. Patton, D.R. Doerge"> i inni</span>, <i>Effect of dietary genistein on cell replication indices in C57BL6 mice</i>, „Cancer Letters”, 195 (2), 2003, s. 139–145, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2FS0304-3835%2803%2900155-1">10.1016/S0304-3835(03)00155-1</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12767521">12767521</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2003&rft.atitle=Effect+of+dietary+genistein+on+cell+replication+indices+in+C57BL6+mice&rft.jtitle=Cancer+Letters&rft.volume=195&rft.edition=2&rft_id=info%3Apmid%2F12767521&rft_id=info%3Adoi%2F10.1016%2FS0304-3835%2803%2900155-1" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Thirman-1993-12"><span class="mw-cite-backlink"><a href="#cite_ref-Thirman-1993_12-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl c"><span class="cite-name-before"><span class="cite-name-full">M.J.</span><span class="cite-name-initials" style="display:none">M.J.</span> </span><span class="cite-lastname">Thirman</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">M.J.</span><span class="cite-name-initials">M.J.</span></span><span class="cite-at-al" title="M.J. Thirman, H.J. Gill, R.C. Burnett, D. Mbangkollo, N.R. McCabe"> i inni</span>, <i>Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations</i>, „<a href="/wiki/The_New_England_Journal_of_Medicine" title="The New England Journal of Medicine">The New England Journal of Medicine</a>”, 329 (13), 1993, s. 909–914, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1056%2FNEJM199309233291302">10.1056/NEJM199309233291302</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/8361504">8361504</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=1993&rft.atitle=Rearrangement+of+the+MLL+gene+in+acute+lymphoblastic+and+acute+myeloid+leukemias+with+11q23+chromosomal+translocations&rft.jtitle=The+New+England+Journal+of+Medicine&rft.volume=329&rft.edition=13&rft_id=info%3Apmid%2F8361504&rft_id=info%3Adoi%2F10.1056%2FNEJM199309233291302" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Strick-2000-13"><span class="mw-cite-backlink"><a href="#cite_ref-Strick-2000_13-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid pmc nourl c"><span class="cite-name-before"><span class="cite-name-full">R.</span><span class="cite-name-initials" style="display:none">R.</span> </span><span class="cite-lastname">Strick</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">R.</span><span class="cite-name-initials">R.</span></span><span class="cite-at-al" title="R. Strick, P.L. Strissel, S. Borgers, S.L. Smith, J.D. Rowley"> i inni</span>, <i>Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia</i>, „<a href="/wiki/Proceedings_of_the_National_Academy_of_Sciences_of_the_United_States_of_America" title="Proceedings of the National Academy of Sciences of the United States of America">Proceedings of the National Academy of Sciences of the United States of America</a>”, 97 (9), 2000, s. 4790–4795, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1073%2Fpnas.070061297">10.1073/pnas.070061297</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10758153">10758153</a>, <a href="/wiki/PMCID" title="PMCID">PMCID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC18311/">PMC18311</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2000&rft.atitle=Dietary+bioflavonoids+induce+cleavage+in+the+MLL+gene+and+may+contribute+to+infant+leukemia&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.volume=97&rft.edition=9&rft_id=info%3Apmid%2F10758153&rft_id=info%3Apmc%2F18311&rft_id=info%3Adoi%2F10.1073%2Fpnas.070061297" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Janssen-2007-14"><span class="mw-cite-backlink"><a href="#cite_ref-Janssen-2007_14-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Sahar Barjesteh van Waalwijk van</span><span class="cite-name-initials" title="Sahar Barjesteh van Waalwijk van" style="display:none">S.B.W.</span> </span><span class="cite-lastname">Doorn-Khosrovani</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Sahar Barjesteh van Waalwijk van</span><span class="cite-name-initials" title="Sahar Barjesteh van Waalwijk van">S.B.W.</span></span><span class="cite-at-al" title="Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Jannie Janssen, Lou M. Maas, Roger W.L. Godschalk, Jan G. Nijhuis"> i inni</span>, <i>Dietary flavonoids induce MLL translocations in primary human CD34+ cells</i>, „Carcinogenesis”, 28 (8), 2007, s. 1703–1709, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1093%2Fcarcin%2Fbgm102">10.1093/carcin/bgm102</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17468513">17468513</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2007&rft.atitle=Dietary+flavonoids+induce+MLL+translocations+in+primary+human+CD34%2B+cells&rft.jtitle=Carcinogenesis&rft.volume=28&rft.edition=8&rft_id=info%3Apmid%2F17468513&rft_id=info%3Adoi%2F10.1093%2Fcarcin%2Fbgm102" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Ross-1998-15"><span class="mw-cite-backlink"><a href="#cite_ref-Ross-1998_15-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">J.A.</span><span class="cite-name-initials" style="display:none">J.A.</span> </span><span class="cite-lastname">Ross</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">J.A.</span><span class="cite-name-initials">J.A.</span></span>, <i>Maternal diet and infant leukemia: a role for DNA topoisomerase II inhibitors?</i>, „International Journal of Cancer”, 11 (Supplement), 1998, s. 26–28, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1002%2F%28SICI%291097-0215%281998%2978%3A11%2B%3C26%3A%3AAID-IJC8%3E3.0.CO%3B2-M">10.1002/(SICI)1097-0215(1998)78:11+<26::AID-IJC8>3.0.CO;2-M</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9876473">9876473</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=1998&rft.atitle=Maternal+diet+and+infant+leukemia%3A+a+role+for+DNA+topoisomerase+II+inhibitors%3F&rft.jtitle=International+Journal+of+Cancer&rft.volume=11&rft.edition=Supplement&rft_id=info%3Apmid%2F9876473&rft_id=info%3Adoi%2F10.1002%2F%28SICI%291097-0215%281998%2978%3A11%2B%3C26%3A%3AAID-IJC8%3E3.0.CO%3B2-M" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Ross-2000-16"><span class="mw-cite-backlink"><a href="#cite_ref-Ross-2000_16-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid pmc nourl c"><span class="cite-name-before"><span class="cite-name-full">J.A.</span><span class="cite-name-initials" style="display:none">J.A.</span> </span><span class="cite-lastname">Ross</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">J.A.</span><span class="cite-name-initials">J.A.</span></span>, <i>Dietary flavonoids and the MLL gene: A pathway to infant leukemia?</i>, „<a href="/wiki/Proceedings_of_the_National_Academy_of_Sciences_of_the_United_States_of_America" title="Proceedings of the National Academy of Sciences of the United States of America">Proceedings of the National Academy of Sciences of the United States of America</a>”, 97 (9), 2000, s. 4411–4413, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1073%2Fpnas.97.9.441115767345">10.1073/pnas.97.9.441115767345</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10781030">10781030</a>, <a href="/wiki/PMCID" title="PMCID">PMCID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC34309/">PMC34309</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2000&rft.atitle=Dietary+flavonoids+and+the+MLL+gene%3A+A+pathway+to+infant+leukemia%3F&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.volume=97&rft.edition=9&rft_id=info%3Apmid%2F10781030&rft_id=info%3Apmc%2F34309&rft_id=info%3Adoi%2F10.1073%2Fpnas.97.9.441115767345" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Spector-2005-17"><span class="mw-cite-backlink"><a href="#cite_ref-Spector-2005_17-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Logan G.</span><span class="cite-name-initials" title="Logan G." style="display:none">L.G.</span> </span><span class="cite-lastname">Spector</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Logan G.</span><span class="cite-name-initials" title="Logan G.">L.G.</span></span><span class="cite-at-al" title="Logan G. Spector, Yang Xie, Leslie L. Robison, Nyla A. Heerema, Joanne M. Hilden"> i inni</span>, <i>Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children’s oncology group</i>, „Cancer Epidemiology, Biomarkers & Prevention”, 14 (3), 2005, s. 651–655, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1158%2F1055-9965.EPI-04-0602">10.1158/1055-9965.EPI-04-0602</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15767345">15767345</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2005&rft.atitle=Maternal+diet+and+infant+leukemia%3A+the+DNA+topoisomerase+II+inhibitor+hypothesis%3A+a+report+from+the+children%E2%80%99s+oncology+group&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.volume=14&rft.edition=3&rft_id=info%3Apmid%2F15767345&rft_id=info%3Adoi%2F10.1158%2F1055-9965.EPI-04-0602" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Upson-18"><span class="mw-cite-backlink"><a href="#cite_ref-Upson_18-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Kristen</span><span class="cite-name-initials" title="Kristen" style="display:none">K.</span> </span><span class="cite-lastname">Upson</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Kristen</span><span class="cite-name-initials" title="Kristen">K.</span></span><span class="cite-at-al" title="Kristen Upson, Margaret A. Adgent, Ganesa Wegienka, Donna D. Baird"> i inni</span>, <i>Soy-based infant formula feeding and menstrual pain in a cohort of women aged 23-35 years</i>, „Human Reproduction”, 2018, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1093%2Fhumrep%2Fdey303">10.1093/humrep/dey303</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/30412246">30412246</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2018&rft.jtitle=Human+Reproduction&rft.atitle=Soy-based+infant+formula+feeding+and+menstrual+pain+in+a+cohort+of+women+aged+23-35+years&rft_id=info%3Apmid%2F30412246&rft_id=info%3Adoi%2F10.1093%2Fhumrep%2Fdey303" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Piotrowska-19"><span class="mw-cite-backlink"><a href="#cite_ref-Piotrowska_19-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Ewa</span><span class="cite-name-initials" title="Ewa" style="display:none">E.</span> </span><span class="cite-lastname">Piotrowska</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Ewa</span><span class="cite-name-initials" title="Ewa">E.</span></span><span class="cite-at-al" title="Ewa Piotrowska, Joanna Jakóbkiewicz-Banecka, Sylwia Barańska, Anna Tylki-Szymańska, Barbara Czartoryska"> i inni</span>, <i>Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses</i>, „European journal of human genetics”, 14 (7), 2006, s. 846–852, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fsj.ejhg.5201623">10.1038/sj.ejhg.5201623</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16670689">16670689</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2006&rft.atitle=Genistein-mediated+inhibition+of+glycosaminoglycan+synthesis+as+a+basis+for+gene+expression-targeted+isoflavone+therapy+for+mucopolysaccharidoses&rft.jtitle=European+journal+of+human+genetics&rft.volume=14&rft.edition=7&rft_id=info%3Apmid%2F16670689&rft_id=info%3Adoi%2F10.1038%2Fsj.ejhg.5201623" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Koton-20"><span class="mw-cite-backlink"><a href="#cite_ref-Koton_20-0">↑</a></span> <span class="reference-text"><cite class="citation web"><span class="cite-name-before"><span class="cite-name-full">Marta</span><span class="cite-name-initials" title="Marta" style="display:none">M.</span> </span><span class="cite-lastname">Koton-Czarnecka</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Marta</span><span class="cite-name-initials" title="Marta">M.</span></span>, <a rel="nofollow" class="external text" href="https://web.archive.org/web/20101018053929/http://www.pulsmedycyny.com.pl/index/archiwum/7244,genisteina,leczeniu,choroby.html"><i>Genisteina w leczeniu choroby Sanfilippo</i></a> [online], Puls Medycyny, 6 września 2006 [zarchiwizowane z <a rel="nofollow" class="external text" href="http://www.pulsmedycyny.com.pl/index/archiwum/7244,genisteina,leczeniu,choroby.html">adresu</a> 2010-10-18]<span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=book&rft.aufirst=Marta&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.btitle=Genisteina+w+leczeniu+choroby+Sanfilippo&rft.date=2006-09-06&rft.aulast=Koton-Czarnecka&rft_id=http%3A%2F%2Fwww.pulsmedycyny.com.pl%2Findex%2Farchiwum%2F7244%2Cgenisteina%2Cleczeniu%2Cchoroby.html" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Wegrzyn-21"><span class="mw-cite-backlink"><a href="#cite_ref-Wegrzyn_21-0">↑</a></span> <span class="reference-text"><cite class="citation web"><a href="/wiki/Grzegorz_W%C4%99grzyn" title="Grzegorz Węgrzyn"><span class="cite-name-before"><span class="cite-name-full">Grzegorz</span><span class="cite-name-initials" title="Grzegorz" style="display:none">G.</span> </span><span class="cite-lastname">Węgrzyn</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Grzegorz</span><span class="cite-name-initials" title="Grzegorz">G.</span></span></a>, <a rel="nofollow" class="external text" href="https://web.archive.org/web/20191002184152/https://www.uratujmyzycie.org.pl/index.php/dla-rodzicow/59-stosowanie-leku-soyfem-w-leczeniu-choroby-sanfilippo"><i>Stosowanie leku Soyfem w leczeniu choroby Sanfilippo</i></a> [online], www.uratujmyzycie.org.pl<span class="accessdate"> [dostęp 2019-10-02]</span> [zarchiwizowane z <a rel="nofollow" class="external text" href="https://www.uratujmyzycie.org.pl/index.php/dla-rodzicow/59-stosowanie-leku-soyfem-w-leczeniu-choroby-sanfilippo">adresu</a> 2019-10-02]<span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=book&rft.aufirst=Grzegorz&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.btitle=Stosowanie+leku+Soyfem+w+leczeniu+choroby+Sanfilippo&rft.aulast=W%C4%99grzyn&rft_id=https%3A%2F%2Fwww.uratujmyzycie.org.pl%2Findex.php%2Fdla-rodzicow%2F59-stosowanie-leku-soyfem-w-leczeniu-choroby-sanfilippo" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Yang2010-22"><span class="mw-cite-backlink"><a href="#cite_ref-Yang2010_22-0">↑</a></span> <span class="reference-text"><cite class="citation journal open-access doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Xiaohe</span><span class="cite-name-initials" title="Xiaohe" style="display:none">X.</span> </span><span class="cite-lastname">Yang</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Xiaohe</span><span class="cite-name-initials" title="Xiaohe">X.</span></span><span class="cite-at-al" title="Xiaohe Yang, Shihe Yang, Christine McKimmey, Bolin Liu, Susan M. Edgerton"> i inni</span>, <i>Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation</i>, „Carcinogenesis”, 31 (4), 2010, s. 695–702, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1093%2Fcarcin%2Fbgq007">10.1093/carcin/bgq007</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/20067990">20067990</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2010&rft.atitle=Genistein+induces+enhanced+growth+promotion+in+ER-positive%2FerbB-2-overexpressing+breast+cancers+by+ER-erbB-2+cross+talk+and+p27%2Fkip1+downregulation&rft.jtitle=Carcinogenesis&rft.volume=31&rft.edition=4&rft_id=info%3Apmid%2F20067990&rft_id=info%3Adoi%2F10.1093%2Fcarcin%2Fbgq007" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Helferich-2008-23"><span class="mw-cite-backlink"><a href="#cite_ref-Helferich-2008_23-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">W.G.</span><span class="cite-name-initials" style="display:none">W.G.</span> </span><span class="cite-lastname">Helferich</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">W.G.</span><span class="cite-name-initials">W.G.</span></span>, <span class="cite-name-before"><span class="cite-name-full">J.E.</span><span class="cite-name-initials" style="display:none">J.E.</span> </span><span class="cite-lastname">Andrade</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">J.E.</span><span class="cite-name-initials">J.E.</span></span>, <span class="cite-name-before"><span class="cite-name-full">M.S.</span><span class="cite-name-initials" style="display:none">M.S.</span> </span><span class="cite-lastname">Hoagland</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">M.S.</span><span class="cite-name-initials">M.S.</span></span>, <i>Phytoestrogens and breast cancer: a complex story</i>, „Inflammopharmacology”, 16 (5), 2008, s. 219–226, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1007%2Fs10787-008-8020-0">10.1007/s10787-008-8020-0</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18815740">18815740</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2008&rft.atitle=Phytoestrogens+and+breast+cancer%3A+a+complex+story&rft.jtitle=Inflammopharmacology&rft.volume=16&rft.edition=5&rft_id=info%3Apmid%2F18815740&rft_id=info%3Adoi%2F10.1007%2Fs10787-008-8020-0" style="display:none"> </span>.</cite></span> </li> <li id="cite_note-Tonetti-2007-24"><span class="mw-cite-backlink"><a href="#cite_ref-Tonetti-2007_24-0">↑</a></span> <span class="reference-text"><cite class="citation journal doi pmid nourl"><span class="cite-name-before"><span class="cite-name-full">Debra A.</span><span class="cite-name-initials" title="Debra A." style="display:none">D.A.</span> </span><span class="cite-lastname">Tonetti</span><span class="cite-name-after" style="display:none"> <span class="cite-name-full">Debra A.</span><span class="cite-name-initials" title="Debra A.">D.A.</span></span><span class="cite-at-al" title="Debra A. Tonetti, Yiyun Zhang, Huiping Zhao, Sok-Bee Lim, Andreas I. Constantinou"> i inni</span>, <i>The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKC alpha</i>, „Nutrition and Cancer”, 58 (2), 2007, s. 222–229, <a href="/wiki/DOI_(identyfikator_cyfrowy)" title="DOI (identyfikator cyfrowy)">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1080%2F01635580701328545">10.1080/01635580701328545</a>, <a href="/wiki/PMID" title="PMID">PMID</a>: <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17640169">17640169</a><span class="Z3988" title="ctx_ver=Z39.88-2004&rft.gengre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.date=2007&rft.atitle=The+effect+of+the+phytoestrogens+genistein%2C+daidzein%2C+and+equol+on+the+growth+of+tamoxifen-resistant+T47D%2FPKC+alpha&rft.jtitle=Nutrition+and+Cancer&rft.volume=58&rft.edition=2&rft_id=info%3Apmid%2F17640169&rft_id=info%3Adoi%2F10.1080%2F01635580701328545" style="display:none"> </span>.</cite></span> </li> </ol></div></div></div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Źródło: „<a dir="ltr" href="https://pl.wikipedia.org/w/index.php?title=Genisteina&oldid=73256216">https://pl.wikipedia.org/w/index.php?title=Genisteina&oldid=73256216</a>”</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Specjalna:Kategorie" title="Specjalna:Kategorie">Kategorie</a>: <ul><li><a href="/wiki/Kategoria:Izoflawony" title="Kategoria:Izoflawony">Izoflawony</a></li><li><a href="/wiki/Kategoria:Polifenole" title="Kategoria:Polifenole">Polifenole</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Ukryte kategorie: <ul><li><a href="/wiki/Kategoria:Szablon_cytowania_zamieni%C5%82_nazw%C4%99_czasopisma" title="Kategoria:Szablon cytowania zamienił nazwę czasopisma">Szablon cytowania zamienił nazwę czasopisma</a></li><li><a href="/wiki/Kategoria:W%C5%82a%C5%9Bciwo%C5%9B%C4%87_P231_taka_sama_jak_wpisana_lokalnie" title="Kategoria:Właściwość P231 taka sama jak wpisana lokalnie">Właściwość P231 taka sama jak wpisana lokalnie</a></li><li><a href="/wiki/Kategoria:W%C5%82a%C5%9Bciwo%C5%9B%C4%87_P234_pobrana_lokalnie" title="Kategoria:Właściwość P234 pobrana lokalnie">Właściwość P234 pobrana lokalnie</a></li><li><a href="/wiki/Kategoria:W%C5%82a%C5%9Bciwo%C5%9B%C4%87_P235_pobrana_lokalnie" title="Kategoria:Właściwość P235 pobrana lokalnie">Właściwość P235 pobrana lokalnie</a></li><li><a href="/wiki/Kategoria:Odno%C5%9Bnik_do_Commons_pobrany_z_Wikidanych_(Zwi%C4%85zek_chemiczny_infobox)" title="Kategoria:Odnośnik do Commons pobrany z Wikidanych (Związek chemiczny infobox)">Odnośnik do Commons pobrany z Wikidanych (Związek chemiczny infobox)</a></li><li><a href="/wiki/Kategoria:W%C5%82a%C5%9Bciwo%C5%9B%C4%87_P662_taka_sama_jak_wpisana_lokalnie" title="Kategoria:Właściwość P662 taka sama jak wpisana lokalnie">Właściwość P662 taka sama jak wpisana lokalnie</a></li><li><a href="/wiki/Kategoria:W%C5%82a%C5%9Bciwo%C5%9B%C4%87_P715_taka_sama_jak_wpisana_lokalnie" title="Kategoria:Właściwość P715 taka sama jak wpisana lokalnie">Właściwość P715 taka sama jak wpisana lokalnie</a></li><li><a href="/wiki/Kategoria:Artyku%C5%82y_z_brakuj%C4%85cymi_przypisami_od_2024-03" title="Kategoria:Artykuły z brakującymi przypisami od 2024-03">Artykuły z brakującymi przypisami od 2024-03</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Tę stronę ostatnio edytowano 25 mar 2024, 07:35.</li> <li id="footer-info-copyright">Tekst udostępniany na licencji <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.pl">Creative Commons: uznanie autorstwa, na tych samych warunkach</a>, z możliwością obowiązywania dodatkowych ograniczeń. 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