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2023 Most Popular Preprints Award | Preprints.org
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.tap\:transition-transform{transition-duration:.15s;transition-property:transform;transition-timing-function:cubic-bezier(.4,0,.2,1)}.slider-tap .tap\:duration-300{transition-duration:.3s}.slider-tooltip-focus:not(.slider-focused) .tt-focus\:hidden{display:none!important}.slider-tooltip-focus.slider-focused:not(.slider-tooltip-hidden) .tt-focused\:block{display:block!important}.slider-tooltip-drag:not(.slider-state-drag) .tt-drag\:hidden{display:none!important}.slider-tooltip-drag.slider-state-drag .tt-dragging\:block\:not\(\.slider-tooltip-hidden\){display:block!important}@media not all and (min-width:1280px){.max-xl\:w-full{width:100%}}@media not all and (min-width:1024px){.max-lg\:items-center{align-items:center}.max-lg\:gap-x-6{-moz-column-gap:1.5rem;column-gap:1.5rem}.max-lg\:pt-lg{padding-top:1.5rem;padding-top:var(--spacing-lg)}}@media 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aria-hidden="true" role="img" data-testid="acute" weight="400" style="" width="16" height="16" viewBox="0 0 16 16" data-v-7bacba3b></svg><span data-v-7bacba3b>Follow up the updates of the awards</span><!--]--><!--[--><!--]--><!----><!----><!--[--><!----><!--]--></span></button><!--]--><!--]--></div></div><div class="m-container mx-auto" style="--container-ideal-width:92.5vw;" data-v-7bacba3b><!--[--><div class="pt-3xl" data-v-7bacba3b><!--[--><button aria-hidden="true" style="position:fixed;top:1;left:1;width:1;height:0;padding:0;margin:-1;overflow:hidden;clip:rect(0, 0, 0, 0);white-space:nowrap;border-width:0;" type="button"></button><div class="m-tabs [&>div]:w-fit"><div role="tablist" aria-orientation="horizontal" class="m-tabs__header relative mb-3 flex gap-2"><!--[--><!--[--><!--]--><!--]--></div><div class="m-tabs__panels"><!--[--><span aria-hidden="true" style="position:fixed;top:1;left:1;width:1;height:0;padding:0;margin:-1;overflow:hidden;clip:rect(0, 0, 0, 0);white-space:nowrap;border-width:0;" id="headlessui-tabs-panel-mui-143790" role="tabpanel" tabindex="-1" class="m-tab-panel focus:outline-none" data-v-7bacba3b></span><span aria-hidden="true" style="position:fixed;top:1;left:1;width:1;height:0;padding:0;margin:-1;overflow:hidden;clip:rect(0, 0, 0, 0);white-space:nowrap;border-width:0;" id="headlessui-tabs-panel-mui-143791" role="tabpanel" tabindex="-1" class="m-tab-panel focus:outline-none" data-v-7bacba3b></span><div id="headlessui-tabs-panel-mui-143792" role="tabpanel" tabindex="0" data-headlessui-state="selected" class="m-tab-panel focus:outline-none" data-v-7bacba3b><!--[--><!--]--></div><!--]--></div></div><!--]--><!----><!----><div class="pt-md" data-v-7bacba3b data-v-851fe0fa><div><!--[--><!--]--><div class="m-container mx-auto flex w-full flex-col-reverse lg:gap-xl py-section-mobile lg:flex-row lg:pb-3xl" style="--container-ideal-width:92.5vw;"><!--[--><main class="flex-auto lg:max-w-[80%] lg:min-h-screen"><!--[--><div class="pb-md lg:pb-lg" data-v-851fe0fa><div data-v-851fe0fa><p class="m-text text-body" data-v-851fe0fa><!--[--> Congratulations to all finalists for their outstanding achievements and contributions. Preprints.org is delighted to announce the 2023 Most Popular Preprints Award winners. This esteemed recognition has been conferred upon the following 16 preprints, acknowledged for accruing the highest votes in their respective subject categories: <!--]--></p></div></div><div class="lg:hidden lg:pb-0 sticky pt-md pb-md top-[4.625rem]" style="z-index:5;" data-v-851fe0fa><a href="#Biology_and_Life_Sciences" data-v-851fe0fa><div class="m-select common-field bg-white" data-v-851fe0fa><!--[--><div class="common-field__wrapper" data-headlessui-state><!----><div class="relative w-full cursor-default"><div class="flex items-center"><button id="headlessui-listbox-button-mui-143798" type="button" aria-haspopup="listbox" aria-expanded="false" data-headlessui-state data-testid="select-activator" class="common-field__dropdown-input [&>span]:overflow-hidden h-10"><span class="flex w-full items-center gap-1 [&>span]:truncate"><!----><span>Biology and Life Sciences</span></span><div class="flex"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="duration-400 transition-transform" style="" width="24" height="24" viewBox="0 0 16 16"></svg></div></button><!----></div><!----></div></div><!--]--><!----></div></a></div><div class="winner-container" data-v-851fe0fa><!--[--><div id="Biology_and_Life_Sciences" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Biology and Life Sciences<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Biology and Life Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Immunology and Microbiology<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Biology and Life Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Immunology and Microbiology<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202309.0139/v4" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">ST</span><span class="sr-only">Syamala Rani Thimmiraju</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Syamala Rani Thimmiraju<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">RA</span><span class="sr-only">Rakesh Adhikari</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Rakesh Adhikari<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MV</span><span class="sr-only">Maria J Villar</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Maria J Villar<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JL</span><span class="sr-only">Jungsoon Lee</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Jungsoon Lee<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">ZL</span><span class="sr-only">Zhuyun Liu</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Zhuyun Liu<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">RK</span><span class="sr-only">Rakhi Kundu</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Rakhi Kundu<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">YC</span><span class="sr-only">Yi-Lin Chen</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Yi-Lin Chen<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SS</span><span class="sr-only">Suman Sharma</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Suman Sharma<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">KG</span><span class="sr-only">Karm Ghei</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Karm Ghei<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">BK</span><span class="sr-only">Brian Keegan</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Brian Keegan<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">LV</span><span class="sr-only">Leroy Versteeg</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Leroy Versteeg<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">PG</span><span class="sr-only">Portia M Gillespie</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Portia M Gillespie<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AC</span><span class="sr-only">Allan Ciciriello</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Allan Ciciriello<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NY</span><span class="sr-only">Nelufa Yesmin</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Nelufa Yesmin<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">CP</span><span class="sr-only">Cristina Poveda</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Cristina Poveda<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NU</span><span class="sr-only">Nestor Uzcategui</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Nestor Uzcategui<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">WC</span><span class="sr-only">Wen-Hsiang Chen</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Wen-Hsiang Chen<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JK</span><span class="sr-only">Jason T Kimata</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Jason T Kimata<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">BZ</span><span class="sr-only">Bin Zhan</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Bin Zhan<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">US</span><span class="sr-only">Ulrich Strych</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Ulrich Strych<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MB</span><span class="sr-only">Maria Elena Bottazzi</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Maria Elena Bottazzi<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">PH</span><span class="sr-only">Peter Hotez</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Peter Hotez<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JP</span><span class="sr-only">Jeroen Pollet</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Jeroen Pollet<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->30 Sep 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Biology and Life Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Ecology, Evolution, Behavior and Systematics<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Biology and Life Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Ecology, Evolution, Behavior and Systematics<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202306.0413/v3" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">LB</span><span class="sr-only">Livia Beccacece</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Livia Beccacece<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">FC</span><span class="sr-only">Filippo Costa</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Filippo Costa<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JP</span><span class="sr-only">Jennifer Paola Pascali</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Jennifer Paola Pascali<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">FG</span><span class="sr-only">Federico Manuel Giorgi</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Federico Manuel Giorgi<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->28 Jun 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Chemistry_and_Materials_Science" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Chemistry and Materials Science<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Chemistry and Materials Science<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Analytical Chemistry<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Chemistry and Materials Science<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Analytical Chemistry<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202306.1846/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Metabolome Mining of Curcuma longa L. Using HPLC-MS/MS and Molecular Networking</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">RB</span><span class="sr-only">Rabin Budhathoki</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Rabin Budhathoki<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AT</span><span class="sr-only">Arjun Prasad Timilsina</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Arjun Prasad Timilsina<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">BR</span><span class="sr-only">Bishnu P. Regmi</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Bishnu P. Regmi<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">KS</span><span class="sr-only">Khaga Raj Sharma</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Khaga Raj Sharma<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NA</span><span class="sr-only">Niraj Aryal</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Niraj Aryal<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NP</span><span class="sr-only">Niranjan Parajuli</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Niranjan Parajuli<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->27 Jun 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Review<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Chemistry and Materials Science<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Medicinal Chemistry<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Chemistry and Materials Science<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Medicinal Chemistry<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202308.1912/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Polymers in 3D Printing of External Maxillofacial Prostheses and Their Retention Systems</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SA</span><span class="sr-only">Samvel V. Apresyan</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Samvel V. Apresyan<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AS</span><span class="sr-only">Alexandr G. Stepanov</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Alexandr G. Stepanov<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AV</span><span class="sr-only">Alexander A. Vikhrov</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Alexander A. Vikhrov<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MM</span><span class="sr-only">Maxim S. Myasoedov</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Maxim S. Myasoedov<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AP</span><span class="sr-only">Anna I. Prostyakova</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Anna I. Prostyakova<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AG</span><span class="sr-only">Alla N. Generalova</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Alla N. Generalova<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->29 Aug 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Computer_Science_and_Mathematics" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Computer Science and Mathematics<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Computer Science and Mathematics<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Algebra and Number Theory<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Computer Science and Mathematics<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Algebra and Number Theory<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202108.0146/v27" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>A Proof of the Riemann Hypothesis Based on a New Expression of the Completed Zeta Function</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">WZ</span><span class="sr-only">Weicun Zhang</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Weicun Zhang<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->30 Oct 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Computer Science and Mathematics<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Artificial Intelligence and Machine Learning<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Computer Science and Mathematics<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Artificial Intelligence and Machine Learning<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202308.0148/v2" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>GPT-4 Can't Reason</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">KA</span><span class="sr-only">Konstantine Arkoudas</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Konstantine Arkoudas<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->07 Aug 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Engineering" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Engineering<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Engineering<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Other<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Engineering<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Other<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202306.1106/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>An Explainable Vision Transformer Model Based White Blood Cells Classification and Localization</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">OK</span><span class="sr-only">Oguzhan Katar</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Oguzhan Katar<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">OY</span><span class="sr-only">Ozal Yildirim</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Ozal Yildirim<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->15 Jun 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Review<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Engineering<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Bioengineering<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Engineering<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Bioengineering<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202303.0072/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Glycosylation Shapes the Efficacy and Safety of Diverse Protein, Gene and Cell Therapies</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">FR</span><span class="sr-only">Frances Rocamora</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Frances Rocamora<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AP</span><span class="sr-only">Angelo G Peralta</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Angelo G Peralta<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SS</span><span class="sr-only">Seunghyeon Shin</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Seunghyeon Shin<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JS</span><span class="sr-only">James Sorrentino</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->James Sorrentino<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MW</span><span class="sr-only">Mina Wu</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Mina Wu<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">ET</span><span class="sr-only">Eric A Toth</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Eric A Toth<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">TF</span><span class="sr-only">Thomas R Fuerst</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Thomas R Fuerst<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NL</span><span class="sr-only">Nathan E Lewis</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Nathan E Lewis<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->03 Mar 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Environmental_and_Earth_Sciences" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Environmental and Earth Sciences<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Environmental and Earth Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Geophysics and Geology<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Environmental and Earth Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Geophysics and Geology<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202302.0390/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Understanding Landslide Expression in SAR Backscatter Data: A Global Study</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">EL</span><span class="sr-only">Erin Lindsay</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Erin Lindsay<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AG</span><span class="sr-only">Alexandra Jarna Ganerød</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Alexandra Jarna Ganerød<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">GD</span><span class="sr-only">Graziella Devoli</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Graziella Devoli<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JR</span><span class="sr-only">Johannes Reiche</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Johannes Reiche<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SN</span><span class="sr-only">Steinar Nordal</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Steinar Nordal<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">RF</span><span class="sr-only">Regula Frauenfelder</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Regula Frauenfelder<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">LT</span><span class="sr-only">Lars-Christian Tokle</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Lars-Christian Tokle<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->22 Feb 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Environmental and Earth Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Remote Sensing<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Environmental and Earth Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Remote Sensing<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202310.2060/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Production of High-Resolution Map of Biomass Carbon over Forests in Malaysia Estimated using Aboveground Carbon Density Indicator (ACDI) and a Collection of 12 Years Inventory Data</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">HO</span><span class="sr-only">Hamdan Omar</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Hamdan Omar<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MM</span><span class="sr-only">Muhamad Afizzul Misman</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Muhamad Afizzul Misman<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">VL</span><span class="sr-only">Valeria Linggok</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Valeria Linggok<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SH</span><span class="sr-only">Suhaini Haron</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Suhaini Haron<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">AB</span><span class="sr-only">Ahmad Ashrin Mohd Bohari</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Ahmad Ashrin Mohd Bohari<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MS</span><span class="sr-only">Mohammad Nor Firdaus Haji Sariee</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Mohammad Nor Firdaus Haji Sariee<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->31 Oct 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Physical_Sciences" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Physical Sciences<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Physical Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Theoretical Physics<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Physical Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Theoretical Physics<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202207.0399/v44" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Euclidean Relativity Solves 15 Mysteries of Physics</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">MN</span><span class="sr-only">Markolf H. Niemz</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Markolf H. Niemz<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->29 Nov 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Physical Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Theoretical Physics<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Physical Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Theoretical Physics<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/201711.0022/v7" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>The Geometrization of Maxwell’s Equations and the Emergence of Gravity</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">RB</span><span class="sr-only">Raymond Beach</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Raymond Beach<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->15 May 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Medicine_and_Pharmacology_&_Public_Health_and_Healthcare" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Medicine and Pharmacology & Public Health and Healthcare<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Review<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Medicine and Pharmacology<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Cardiac and Cardiovascular Systems<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Medicine and Pharmacology<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Cardiac and Cardiovascular Systems<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202307.1198/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Autopsy Proven Fatal COVID-19 Vaccine-Induced Myocarditis</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NH</span><span class="sr-only">Nicolas Hulscher</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Nicolas Hulscher<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">RH</span><span class="sr-only">Roger Hodkinson</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Roger Hodkinson<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">WM</span><span class="sr-only">William Makis</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->William Makis<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">PM</span><span class="sr-only">Peter McCullough</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Peter McCullough<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->18 Jul 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Medicine and Pharmacology<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Oncology and Oncogenics<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Medicine and Pharmacology<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Oncology and Oncogenics<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202108.0327/v3" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens against E2F1-Driven Melanoma Progression</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NS</span><span class="sr-only">Nivedita Singh</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Nivedita Singh<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">FK</span><span class="sr-only">Faiz M. Khan</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Faiz M. Khan<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">LB</span><span class="sr-only">Lakshmi Bala</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Lakshmi Bala<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">JV</span><span class="sr-only">Julio Vera</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Julio Vera<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">OW</span><span class="sr-only">Olaf Wolkenhauer</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Olaf Wolkenhauer<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">BP</span><span class="sr-only">Brigitte Pützer</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Brigitte Pützer<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SL</span><span class="sr-only">Stella Logotheti</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Stella Logotheti<!--]--></p></div><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">SG</span><span class="sr-only">Shailendra K. Gupta</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Shailendra K. Gupta<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->12 Jun 2023<!--]--></p></div></div><!--]--><div data-v-851fe0fa><div class="flex items-center justify-between pt-md" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-semibold" data-v-851fe0fa><!--[-->Finalist<!--]--></h6><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg></div><!----></div></div></div><div id="Social_Sciences,_Arts_and_Humanities_&_Business,_Economics_and_Management" class="heading-with-anchor" data-v-851fe0fa><div class="bg-surface-subtle p-md rounded-xl mb-lg" data-v-851fe0fa><h5 class="m-heading text-inherit m-h5 font-semibold" data-v-851fe0fa><!--[-->Social Sciences, Arts and Humanities & Business, Economics and Management<!--]--></h5><!--[--><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><div class="m-icon-custom text-color-inherit" data-v-851fe0fa><!--[--><img src="/_ipx/s_24x24/icons/workspace_premium.png" onerror="this.setAttribute('data-error', 1)" width="24" height="24" alt="Bookmarked" data-nuxt-img srcset="/_ipx/s_24x24/icons/workspace_premium.png 1x, /_ipx/s_48x48/icons/workspace_premium.png 2x" role="img" class="mx-auto" data-v-851fe0fa><!--]--></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>1st Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Social Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Education<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div></div><div class="block lg:hidden text-right" data-v-851fe0fa><div class="flex justify-end my-sm" data-v-851fe0fa><button class="m-button m-button--lg m-button--tertiary rounded" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--><!--[--> Download <!--]--><!----><!----><!--[--><!----><!--]--></span></button></div><div class="flex flex-wrap" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded !p-sm !text-color-subtle mr-xs mb-xs" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Social Sciences<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 !h-6 rounded lg:ml-sm !p-sm !text-color-subtle" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Education<!--]--></span><!--[--><!----><!--]--><!----></div></div></div><div class="pt-sm" data-v-851fe0fa><a href="/manuscript/202312.0564/v1" data-v-851fe0fa><h6 class="m-heading text-inherit m-h6 font-normal" data-v-851fe0fa>Bridging Digital Competence and Sustainability: Unveiling the Synergistic Potential of Design and Maker Education</h6></a></div><div class="flex items-center flex-wrap" data-v-851fe0fa><!--[--><div class="flex items-center pr-sm pt-xs" data-v-851fe0fa><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] flex-none text-xs" data-testid="m-avatar" data-v-851fe0fa><span translate="no">NL</span><span class="sr-only">Noble Po-kan Lo</span></div><p class="m-text text-xs pl-xs" data-v-851fe0fa><!--[-->Noble Po-kan Lo<!--]--></p></div><!--]--></div><!----><div class="pt-sm" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><!--[--><!----><!--]--><!--[--> See More <!--]--><!----><!----><!--[--><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16" data-v-851fe0fa></svg><!--]--></span></button></div><div data-v-851fe0fa><p class="m-text text-sm !text-color-subtle pt-sm" data-v-851fe0fa><!--[-->08 Dec 2023<!--]--></p></div></div><div class="pb-md border-b border-color-default" data-v-851fe0fa><div class="pt-md flex" data-v-851fe0fa><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="workspace_premium" style="" width="24" height="24" viewBox="0 0 16 16" data-v-851fe0fa></svg><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-default !text-color-default !h-6 font-semibold rounded ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[--><span data-v-851fe0fa>2nd Prize</span><!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 !bg-brand-sunken !text-color-default !h-6 font-semibold ml-sm !p-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Article<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="hidden lg:block lg:flex pt-md justify-between items-center" data-v-851fe0fa><div class="lg:flex" data-v-851fe0fa><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Business, Economics and Management<!--]--></span><!--[--><!----><!--]--><!----></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 border border-color-bold px-2 rounded lg:ml-sm" data-v-851fe0fa><!--[--><!----><!--]--><span class="flex items-center whitespace-nowrap text-xs leading-normal"><!--[-->Business and Management<!--]--></span><!--[--><!----><!--]--><!----></div></div><div class="flex" data-v-851fe0fa><button class="m-button m-button--sm m-button--tertiary rounded after:hidden" type="button" data-v-851fe0fa><!----><span class="inline-flex 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Preprints","288-posts","/blog/category/learn-about-preprints",{"id":15,"title":16,"cacheKey":17,"href":18},1383,"Platform Features","1383-posts","/blog/category/platform-features",{"id":20,"title":21,"cacheKey":22,"href":23},22,"Community Content","22-posts","/blog/category/community-content",{"id":25,"title":26,"cacheKey":27,"href":28},1351,"Featured Preprints","1351-posts","/blog/category/featured-preprints",{"id":30,"title":31,"cacheKey":32,"href":33},1380,"Preprints and Society","1380-posts","/blog/category/preprints-and-society",{"id":35,"title":36,"cacheKey":37,"href":38},1381,"News and Announcements","1381-posts","/blog/category/news-and-announcements",{"cacheTime":7},{"code":41,"msg":42,"data":43},0,"success",{"url":44},"https://www.preprints.org/rss",{"code":41,"msg":42,"data":46},{"subscribed":47},false,{"code":41,"msg":42,"data":49},[50,57,64,71,78,85,91,98,105,112,119],{"id":7,"name":51,"name_system":52,"parent_id":53,"image_banner":54,"description":55,"converted_name_system":56},"Arts and Humanities","arts_and_humanities",null,"https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/bb621e164c1f8a2a8bfd78d6ac510e15.jpg","Immerse yourself in a world of creativity and critical thinking with our preprints in arts and humanities. Uncover the depths of human expression, history, and thought across disciplines like archaeology, literature, and philosophy. Explore diverse perspectives that enrich our understanding of cultural heritage and the human experience.","arts-and-humanities",{"id":58,"name":59,"name_system":60,"parent_id":53,"image_banner":61,"description":62,"converted_name_system":63},16,"Biology and Life Sciences","biology_and_life_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/8d795777f5834c04ac4b98f9c94c4c6b.jpg","Journey into the intricate world of living organisms with our preprints. From molecular mechanisms to ecosystem interactions, discover the wonders of life and the natural world through cutting-edge research. Dive into the forefront of biological discovery and explore the complexities of our living world.","biology-and-life-sciences",{"id":65,"name":66,"name_system":67,"parent_id":53,"image_banner":68,"description":69,"converted_name_system":70},41,"Business, Economics and Management","business_economics_and_management","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/ab197ef385773a30f4650e40ae8f03d5.jpg","Explore the dynamic world of business operations, economic theories, and organizational leadership with our preprints. Uncover insights in business, economics, and management that shape global commerce and innovation. Stay informed on the latest trends and research driving the landscape of business and economics.","business-economics-and-management",{"id":72,"name":73,"name_system":74,"parent_id":53,"image_banner":75,"description":76,"converted_name_system":77},50,"Chemistry and Materials Science","chemistry_and_materials_science","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/cc2a7d5d84540df918315b4feb38028a.jpg","Unravel the mysteries of matter and its transformations with our preprints. From atomic structures to novel material synthesis, stay informed on the latest research in this fascinating field. Explore the diverse properties and applications of chemistry and materials science that shape our world.","chemistry-and-materials-science",{"id":79,"name":80,"name_system":81,"parent_id":53,"image_banner":82,"description":83,"converted_name_system":84},71,"Computer Science and Mathematics","computer_science_and_mathematics","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/5b0a41a25a67d1112cb8833b497bf7be.jpg","Embark on a journey through the foundational principles of algorithms, artificial intelligence, and mathematical theories with our preprints. Explore cutting-edge research in computational mathematics and data analysis that drives innovation in the digital age. Dive into a world of innovation and discovery in this exciting field.","computer-science-and-mathematics",{"id":86,"name":87,"name_system":88,"parent_id":53,"image_banner":89,"description":90,"converted_name_system":88},94,"Engineering","engineering","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/908d2aac5be9f3be128d20cc98154c17.jpg","Explore the diverse realms of engineering with our preprints, where innovation meets expertise across various disciplines. From industrial processes to energy technologies, delve into the forefront of engineering advancements. Stay updated on the latest research shaping the dynamic and ever-evolving field of engineering.",{"id":92,"name":93,"name_system":94,"parent_id":53,"image_banner":95,"description":96,"converted_name_system":97},113,"Environmental and Earth Sciences","environmental_and_earth_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/427574c3272a512b9412d12b3bfb3f51.jpg","Investigate the dynamic processes shaping our planet with our preprints. From atmospheric phenomena to oceanography, explore the interconnected systems of our planet and the innovative solutions shaping its future. Stay informed on research that impacts our environment and sustainability.","environmental-and-earth-sciences",{"id":99,"name":100,"name_system":101,"parent_id":53,"image_banner":102,"description":103,"converted_name_system":104},130,"Medicine and Pharmacology","medicine_and_pharmacology","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/98c86d1fdf40abfda51ca959f75f3499.jpg","Embark on a journey through the vast world of medicine and pharmacology with our preprints. Explore breakthroughs in healthcare, from cardiology to neurology, which improve human health outcomes. Delve into the frontiers of medical research and pharmaceutical development that enhance quality of life.","medicine-and-pharmacology",{"id":106,"name":107,"name_system":108,"parent_id":53,"image_banner":109,"description":110,"converted_name_system":111},166,"Physical Sciences","physical_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/c2d6e400b105b8c3d32ec59f26ab969d.jpg","Explore the fundamental laws governing matter and energy in the universe with our preprints. From quantum mechanics to cosmology, stay abreast of research that advances our understanding of the natural world. Dive into a world of scientific discovery that pushes the boundaries of knowledge.","physical-sciences",{"id":113,"name":114,"name_system":115,"parent_id":53,"image_banner":116,"description":117,"converted_name_system":118},185,"Public Health and Healthcare","public_health_and_healthcare","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/ef7c6de55fa117659c3b6090edc7c4ff.jpg","Examine critical issues in public health policy, epidemiology, and healthcare systems with our preprints. Stay updated on research into health disparities, infectious disease control, and healthcare management, which informs public health interventions. Explore the latest trends in healthcare that impact population well-being and equity.","public-health-and-healthcare",{"id":120,"name":121,"name_system":122,"parent_id":53,"image_banner":123,"description":124,"converted_name_system":125},193,"Social Sciences","social_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-09-12/910c960e3a6808861523728f0f26b2df.png","Gain insights into human behavior, societies, and cultures with our preprints. Explore disciplines like psychology, sociology, and political science, which shape our world and inform public policy. Stay engaged with research that explores social issues, cultural dynamics, and economic systems, enriching our understanding of human interactions.","social-sciences",{"code":41,"msg":42,"data":127},[128,765,1137,1378,1764,2309,2467,2941],{"category":59,"manuscripts":129},[130,268,305,361,405,472,523,581,694,748],{"manuscript_id":131,"manuscript_version":132,"hash_key":133,"id":134,"version":132,"voted":47,"votes":135,"article_title":136,"article_abstract":137,"article_keywords":138,"top_subject_name":59,"subject_name":139,"article_type_name":140,"published_at":141,"download_url":142,"rank":7,"authors":143},"202309.0139",4,"6fcd046eaa9e9ec635f3fdc49c4a2281",70,271,"A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2","(1) Background: We previously reported the development of a recombinant protein SARS-CoV-2 vaccine, consisting of the Receptor-Binding Domain (RBD) of the SARS-CoV-2 spike protein, adjuvanted with aluminum hydroxide (alum) and CpG oligonucleotides. In mice and non-human primates, our wild-type (WT) RBD vaccine induced high neutralizing antibody titers against the WT isolate of the virus, and, with partners in India and Indonesia it was later developed into two closely resembling human vaccines, Corbevax and Indovac. Here, we describe the development and characterization of a next-generation vaccine adapted to the recently emerging XBB variants of SARS-CoV-2. (2) Methods: We conducted preclinical studies in mice using a novel yeast-produced SARS-CoV-2 XBB.1.5 RBD subunit vaccine candidate formulated with alum and CpG. We examined the neutralization profile of sera obtained from mice vaccinated twice intramuscularly at a 21-day interval with the XBB.1.5-based RBD vaccine, against WT, Beta, Delta, BA.4, BQ.1.1, BA.2.75.2, XBB.1.16, XBB.1.5 and EG.5.1 SARS-CoV-2 pseudoviruses. (3) Results: The XBB.1.5 RBD/CpG/alum vaccine elicited a robust antibody response in mice. Furthermore, serum from vaccinated mice demonstrated potent neutralization against the XBB.1.5 pseudovirus as well as several other Omicron pseudoviruses. However, regardless of high antibody cross-reactivity by ELISA, the anti-XBB.1.5 RBD antigen serum showed low neutralizing titers against the WT and Delta virus variants. (4) Conclusions: Whereas we observed modest cross-neutralization against Omicron subvariants by sera from mice vaccinated with the WT RBD/CpG/Alum vaccine or with the BA.4/5-based vaccine, sera raised against the XBB.1.5 RBD showed robust cross-neutralization. These findings underscore the imminent opportunity for an updated vaccine formulation utilizing the XBB.1.5 RBD antigen.","Immune escape; Vaccine efficacy; COVID-19; SARS-CoV-2","Immunology and Microbiology","Article","2023-09-30 07:44:51","/frontend/manuscript/6fcd046eaa9e9ec635f3fdc49c4a2281/download_pub",[144,150,155,160,165,170,175,180,185,190,195,201,207,212,217,222,227,232,238,244,250,256,261],{"id":145,"name":146,"email":147,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":149},405746,"Syamala Rani Thimmiraju","syamala.thimmiraju@bcm.edu","","https://sciprofiles.com/profile/3160160",{"id":151,"name":152,"email":153,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":154},405747,"Rakesh Adhikari","rakesh.adhikari@bcm.edu","https://sciprofiles.com/profile/author/ejRLTFpzWURFTnVYRHVDYTlDeGVITjQweWI1Ukl2d01uVmx4ME5BUmQ3az0=",{"id":156,"name":157,"email":158,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":159},405748,"Maria J Villar","mariajose.villarmondragon@bcm.edu","https://sciprofiles.com/profile/author/YjVuUjRrTkhJRUJhRTVsL2F0T1VzRlFEYjgvdmtEd3VIL2lsTjR1eTBLWWtEZVMrUi9Hekk4TWdlTW9XRXAwNA==",{"id":161,"name":162,"email":163,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":164},405749,"Jungsoon Lee","jslee@bcm.edu","https://sciprofiles.com/profile/author/MHNSV0VXbmVkaWhxYWU2VEM0ZGhMQT09",{"id":166,"name":167,"email":168,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":169},405750,"Zhuyun Liu","zhuyun.liu@bcm.edu","https://sciprofiles.com/profile/author/TkNteXFmYzhVR3FtSlFrd2VqZTJudmhJUkdFL2hrRDl1VmQ0WVpsY2pycz0=",{"id":171,"name":172,"email":173,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":174},405751,"Rakhi Kundu","rakhi.tyagikundu@bcm.edu","https://sciprofiles.com/profile/author/b3dtTDBHd0czd25zSXNlV3VMY1FBTSt4WjRkcGo4akNEeSt6cXppSDV2RT0=",{"id":176,"name":177,"email":178,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":179},405752,"Yi-Lin Chen","yi-lin.chen@bcm.edu","https://sciprofiles.com/profile/author/dkZVMUpUalM1eEo5d2lSMDBlMXdUT0VITTg2SlN6WEVkbytma1JPTmU1Yz0=",{"id":181,"name":182,"email":183,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":184},405753,"Suman Sharma","suman.sharma@bcm.edu","https://sciprofiles.com/profile/3140884",{"id":186,"name":187,"email":188,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":189},405754,"Karm Ghei","karm.ghei@bcm.edu","https://sciprofiles.com/profile/author/NVAwVGdiN1Y0ejFycUJCY2tMM3pKa09BZ2NuTytCaWFDaEx2alBjbjdJZz0=",{"id":191,"name":192,"email":193,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":194},405755,"Brian Keegan","bkeegan@bcm.edu","https://sciprofiles.com/profile/author/cTBYYnZoUEQwQ1hsaXJOdWRsdmdnUT09",{"id":196,"name":197,"email":198,"is_corresponding":47,"orcid_link":199,"author_mark":148,"sp_link":200},405756,"Leroy Versteeg","leroy.versteeg@bcm.edu","https://orcid.org/0000-0001-5250-5746","https://sciprofiles.com/profile/1069287",{"id":202,"name":203,"email":204,"is_corresponding":47,"orcid_link":205,"author_mark":148,"sp_link":206},405757,"Portia M Gillespie","pmgilles@bcm.edu","https://orcid.org/0000-0003-2951-4550","https://sciprofiles.com/profile/3160335",{"id":208,"name":209,"email":210,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":211},405758,"Allan Ciciriello","allan.ciciriello@bcm.edu","https://sciprofiles.com/profile/author/cUpwU0oxbi9XaUE2WjRDeG90SU01NHVpWUxRQnpFUjRYZFBlUVhoa2x5OD0=",{"id":213,"name":214,"email":215,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":216},405759,"Nelufa Yesmin","nelufa.islam@bcm.edu","https://sciprofiles.com/profile/3140460",{"id":218,"name":219,"email":220,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":221},405760,"Cristina Poveda","cristina.poveda@bcm.edu","https://sciprofiles.com/profile/826495",{"id":223,"name":224,"email":225,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":226},405761,"Nestor Uzcategui","nestor.uzcateguiaraujo@bcm.edu","https://sciprofiles.com/profile/author/YS9yUmFTNmtlM245VFdDeW1kWndjSHMzbUVjVm9iK0NqUU9pcHJVcWJZVT0=",{"id":228,"name":229,"email":230,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":231},405762,"Wen-Hsiang Chen","wen-hsiang.chen@bcm.edu","https://sciprofiles.com/profile/960591",{"id":233,"name":234,"email":235,"is_corresponding":47,"orcid_link":236,"author_mark":148,"sp_link":237},405763,"Jason T Kimata","jkimata@bcm.edu","https://orcid.org/0000-0002-0504-0090","https://sciprofiles.com/profile/27095",{"id":239,"name":240,"email":241,"is_corresponding":47,"orcid_link":242,"author_mark":148,"sp_link":243},405764,"Bin Zhan","bzhan@bcm.edu","https://orcid.org/0000-0002-6884-9452","https://sciprofiles.com/profile/374033",{"id":245,"name":246,"email":247,"is_corresponding":47,"orcid_link":248,"author_mark":148,"sp_link":249},405765,"Ulrich Strych","ulrich.strych@bcm.edu","https://orcid.org/0000-0001-9455-7683","https://sciprofiles.com/profile/817343",{"id":251,"name":252,"email":253,"is_corresponding":47,"orcid_link":254,"author_mark":148,"sp_link":255},405766,"Maria Elena Bottazzi","bottazzi@bcm.edu","https://orcid.org/0000-0002-8429-0476","https://sciprofiles.com/profile/452869",{"id":257,"name":258,"email":259,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":260},405767,"Peter Hotez","hotez@bcm.edu","https://sciprofiles.com/profile/1035424",{"id":262,"name":263,"email":264,"is_corresponding":6,"orcid_link":265,"author_mark":266,"sp_link":267},405768,"Jeroen Pollet","jeroen.pollet@bcm.edu","https://orcid.org/0000-0003-1420-4015","*","https://sciprofiles.com/profile/452873",{"manuscript_id":269,"manuscript_version":270,"hash_key":271,"id":272,"version":270,"voted":47,"votes":273,"article_title":274,"article_abstract":275,"article_keywords":276,"top_subject_name":59,"subject_name":277,"article_type_name":140,"published_at":278,"download_url":279,"rank":280,"authors":281},"202306.0413",3,"72f7a40bfa1b1afa42680769324ec9e6",65,122,"Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)","In the recent decades, per- and polyfluoroalkyl substances (PFAS) have garnered widespread public attention due to their persistence in the environment and detrimental effects on the health of living organisms, spurring the generation of several transcriptome-centered investigations to understand the biological basis of their mechanism. In this study, we collected 2144 publicly available samples from 7 distinct animal species to examine the molecular responses to PFAS exposure and to determine if there are conserved responses. Our comparative transcriptional analysis revealed that exposure to PFAS is conserved across different tissues, molecules and species. We identified and reported several genes exhibiting consistent and evolutionarily conserved transcriptional response to PFAS, such as \u003Cem>ESR1\u003C/em>, \u003Cem>HADHA\u003C/em> and \u003Cem>ID1\u003C/em>, as well as several pathways including lipid metabolism, immune response and hormone pathways. This study provides the first evidence that distinct PFAS molecules induce comparable transcriptional changes and affect the same metabolic processes across inter-species borders. Our findings have significant implications for understanding the impact of PFAS exposure on living organisms and the environment. We believe that this study offers a novel perspective on the molecular responses to PFAS exposure and provides a foundation for future research into developing strategies for mitigating the detrimental effects of these substances in the ecosystem.","PFAS; metabolism; transcriptomics; transcriptome; cross-species analysis","Ecology, Evolution, Behavior and Systematics","2023-06-28 02:33:02","/frontend/manuscript/72f7a40bfa1b1afa42680769324ec9e6/download_pub",2,[282,288,294,299],{"id":283,"name":284,"email":285,"is_corresponding":47,"orcid_link":286,"author_mark":148,"sp_link":287},360455,"Livia Beccacece","livia.beccacece2@unibo.it","https://orcid.org/0000-0001-9437-0456","https://sciprofiles.com/profile/2747483",{"id":289,"name":290,"email":291,"is_corresponding":47,"orcid_link":292,"author_mark":148,"sp_link":293},360456,"Filippo Costa","filippo.costa9@studio.unibo.it","https://orcid.org/0009-0005-8229-0009","https://sciprofiles.com/profile/3028485",{"id":295,"name":296,"email":297,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":298},360457,"Jennifer Paola Pascali","jennifer.pascali@unipd.it","https://sciprofiles.com/profile/author/S2dVRkl0bVZtRTBQSVNCWHM1czlRTjltL3lrUUJ4YTF3MnNlcHhGdStVYz0=",{"id":300,"name":301,"email":302,"is_corresponding":6,"orcid_link":303,"author_mark":266,"sp_link":304},360458,"Federico Manuel Giorgi","federico.giorgi@unibo.it","https://orcid.org/0000-0002-7325-9908","https://sciprofiles.com/profile/868493",{"manuscript_id":306,"manuscript_version":7,"hash_key":307,"id":308,"version":7,"voted":47,"votes":309,"article_title":310,"article_abstract":311,"article_keywords":312,"top_subject_name":59,"subject_name":313,"article_type_name":314,"published_at":315,"download_url":316,"rank":53,"authors":317},"202302.0142","b52e552342e37df44db08d263c10ab24",64,96,"Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines","In the recent days, lipid nanoparticles have been successfully emerged as one of the most advanced technology for highly efficient in vivo delivery of exogenous mRNA, especially for delivery of COVID-19 vaccines. For the vaccines to be successful or protective, they require highly efficient mRNA delivery systems. However, developing effective, translatable vaccines with better safety against some of the SARS‐CoV‐2 variants is still a challenge. Lipid nanoparticles (LNPs) are composed of four different types of lipids including ionizable lipids, helper or neutral lipids, cholesterol and polyethylene glycol (PEG) attached lipids. In this review, we present recent advancements and insights in designing the advanced LNPs and their composition and properties, with a subsequent discussion on the development of COVID-19 vaccines. In particular, as the ionizable lipids are most important drivers for complexing the mRNA and in vivo delivery, the role of ionizable lipids in mRNA vaccines discussed in detail. Furthermore, the use of LNPs as effective delivery vehicles for vaccination, genome editing, and protein replacement therapy were discussed. Finally, expert opinion of LNPs for mRNA vaccines were discussed which might address the future challenges in the development of mRNA vaccines employing highly efficient LNPs using novel set of ionizable lipids.","vaccine; mRNA; COVID 19; lipid nanoparticles","Biology and Biotechnology","Review","2023-02-08 09:55:30","/frontend/manuscript/b52e552342e37df44db08d263c10ab24/download_pub",[318,323,328,334,339,345,350,356],{"id":319,"name":320,"email":321,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":322},315308,"K Swetha","kswetha22@iisertvm.ac.in","https://sciprofiles.com/profile/2835693",{"id":324,"name":325,"email":326,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":327},315309,"Niranjan G Kotla","niranjan.kotla5@gmail.com","https://sciprofiles.com/profile/author/eGtvT3ZvdTE0RzlUOUxGRHVQUDJ0aEVLMmxXdk5GeWlpaXcydGJoRHpUcz0=",{"id":329,"name":330,"email":331,"is_corresponding":47,"orcid_link":332,"author_mark":148,"sp_link":333},315310,"Lakshmi Tunki","tunkilakshmi@gmail.com","https://orcid.org/0000-0002-5713-9447","https://sciprofiles.com/profile/2774647",{"id":335,"name":336,"email":337,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":338},315311,"Arya Jayaraj","arya18@iisertvm.ac.in","https://sciprofiles.com/profile/author/ZjcwL1BVclVscTQ0eDZMNlNvM0pHNTMyb3djelNrKzNvSWFHR0JIaXJscz0=",{"id":340,"name":341,"email":342,"is_corresponding":47,"orcid_link":343,"author_mark":148,"sp_link":344},315312,"Suresh K. Bhargava","suresh.bhargava@rmit.edu.au","https://orcid.org/0000-0002-3127-8166","https://sciprofiles.com/profile/175066",{"id":346,"name":347,"email":348,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":349},315313,"Haitao Hu","haihu@utmb.edu","https://sciprofiles.com/profile/author/b3Jpam9QUjI4eUhVRXR1RDVYU3htdz09",{"id":351,"name":352,"email":353,"is_corresponding":6,"orcid_link":354,"author_mark":266,"sp_link":355},315314,"Srinivasa Reddy Bonam","bsrpharmacy90@gmail.com","https://orcid.org/0000-0002-2888-2418","https://sciprofiles.com/profile/342110",{"id":357,"name":358,"email":359,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":360},315315,"Rajendra Kurapati","rkurapati@iisertvm.ac.in","https://sciprofiles.com/profile/2856444",{"manuscript_id":362,"manuscript_version":280,"hash_key":363,"id":364,"version":280,"voted":47,"votes":86,"article_title":365,"article_abstract":366,"article_keywords":367,"top_subject_name":59,"subject_name":313,"article_type_name":140,"published_at":368,"download_url":369,"rank":53,"authors":370},"202212.0304","2463f2c687d85a7a0896b83270e3b491",63,"Endogenous TOM20 Proximity Labelling: A Swiss-Knife for the Study of Mitochondrial Proteins in Human Cells","Biotin-based proximity labeling approaches, such as BioID, have demonstrated their use for the study of mitochondria proteomes in living cells. The use of genetically engineered BioID cell lines enables the detailed characterization of poorly characterized processes such as mitochondrial co-translational import. In this process, translation is coupled to the translocation of the mitochon-drial proteins, alleviating the energy cost typically associated with the post-translational import relying on chaperone systems. However, the mechanisms are still unclear with only few actors identified but none that have been described in mammals yet. We thus profiled the TOM20 prox-isome using BioID, assuming that some of identified proteins could be molecular actors of the co-translational import in human cells. The obtained results showed a high enrichment of RNA bind-ing proteins close to the TOM complex. However, for the few selected candidates, we could not demonstrate a role in the mitochondrial co-translational import process. Nonetheless, we were able to demonstrate additional uses of our BioID cell line. Indeed, the experimental approach used in this study is thus proposed for the identification of mitochondrial co-translational import effec-tors and for the monitoring of protein entry inside mitochondria with a potential application in the prediction of mitochondrial protein half-life.","Mitochondria; Co-translational import; BioID; Protein identification; Mass spectrometry","2023-04-21 09:03:58","/frontend/manuscript/2463f2c687d85a7a0896b83270e3b491/download_pub",[371,377,383,388,394,399],{"id":372,"name":373,"email":374,"is_corresponding":47,"orcid_link":375,"author_mark":148,"sp_link":376},328574,"Sébastien Meurant","sebastien.meurant@unamur.be","https://orcid.org/0000-0003-0711-9605","https://sciprofiles.com/profile/2652579",{"id":378,"name":379,"email":380,"is_corresponding":47,"orcid_link":381,"author_mark":148,"sp_link":382},328575,"Lorris Mauclet","lorris.mauclet@student.unamur.be","https://orcid.org/0000-0002-1444-875X","https://sciprofiles.com/profile/2974305",{"id":384,"name":385,"email":386,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":387},328576,"Marc Dieu","marc.dieu@unamur.be","https://sciprofiles.com/profile/author/dUd3TTllWmc4RkVhaUFPcGw1ZUFwOGdINUlVZzJhc0lFSEJYWE9JdERZVT0=",{"id":389,"name":390,"email":391,"is_corresponding":47,"orcid_link":392,"author_mark":148,"sp_link":393},328577,"Thierry Arnould","thierry.arnould@unamur.be","https://orcid.org/0000-0003-2101-2660","https://sciprofiles.com/profile/81231",{"id":395,"name":396,"email":397,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":398},328578,"Sven Eyckerman","sven.eyckerman@ugent.vib.be","https://sciprofiles.com/profile/2974945",{"id":400,"name":401,"email":402,"is_corresponding":6,"orcid_link":403,"author_mark":266,"sp_link":404},328579,"Patricia Renard","patsy.renard@unamur.be","https://orcid.org/0000-0003-4144-3353","https://sciprofiles.com/profile/218110",{"manuscript_id":406,"manuscript_version":7,"hash_key":407,"id":408,"version":7,"voted":47,"votes":409,"article_title":410,"article_abstract":411,"article_keywords":412,"top_subject_name":59,"subject_name":413,"article_type_name":314,"published_at":414,"download_url":415,"rank":53,"authors":416},"202301.0183","633d0534e0ff63c23c6f1acdbed40aea",68,76,"Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer","Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation is closely associated with metabolism in mammalian cells acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. Also, we discuss the impact of these metabolic pathways on autophagy in lung cancer.","lung cancer; Lipid Metabolism; Glucose Metabolism; Krebs Cycle; Cholesterol Metabolism","Biochemistry and Molecular Biology","2023-01-10 10:39:28","/frontend/manuscript/633d0534e0ff63c23c6f1acdbed40aea/download_pub",[417,423,428,434,439,444,450,456,461,466],{"id":418,"name":419,"email":420,"is_corresponding":47,"orcid_link":421,"author_mark":148,"sp_link":422},309125,"Javad Alizadeh","alizadej@myumanitoba.ca","https://orcid.org/0000-0001-9082-3083","https://sciprofiles.com/profile/1344513",{"id":424,"name":425,"email":426,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":427},309126,"Mahboubeh Kavoosi","mah.kavoosi@gmail.com","https://sciprofiles.com/profile/author/V0xQaUVsdG8yNVhNVzdLcVlGdWdiOEgzcTlVeE8xSmI5ZTNqYTk4d0ZXaz0=",{"id":429,"name":430,"email":431,"is_corresponding":47,"orcid_link":432,"author_mark":148,"sp_link":433},309127,"Navjit Singh","singhn11@myumanitoba.ca","https://orcid.org/0009-0007-8127-4845","https://sciprofiles.com/profile/2868258",{"id":435,"name":436,"email":437,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":438},309128,"Shahrokh Lorzadeh","shahrokh.lorzadeh@umanitoba.ca","https://sciprofiles.com/profile/2589198",{"id":440,"name":441,"email":442,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":443},309129,"Amir Ravandi","amir.ravandi@umanitoba.ca","https://sciprofiles.com/profile/554890",{"id":445,"name":446,"email":447,"is_corresponding":47,"orcid_link":448,"author_mark":148,"sp_link":449},309130,"Biniam Kidane","bkidane@hsc.mb.ca","https://orcid.org/0000-0002-2982-2505","https://sciprofiles.com/profile/2283065",{"id":451,"name":452,"email":453,"is_corresponding":47,"orcid_link":454,"author_mark":148,"sp_link":455},309131,"Naseer Ahmed","nahmed2@cancercare.mb.ca","https://orcid.org/0000-0003-2021-1959","https://sciprofiles.com/profile/197435",{"id":457,"name":458,"email":459,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":460},309132,"Fatima Mraiche","fatima.mraiche2010@gmail.com","https://sciprofiles.com/profile/author/ZWhEVk9CbllwbE5UeWI4THYzZmk2eW9VS0FidWw2RDgyRTljSDNvNGVwdz0=",{"id":462,"name":463,"email":464,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":465},309133,"Michael R Mowat","michael.mowat@umanitoba.ca","https://sciprofiles.com/profile/author/L3UvdmJwUFpDZGd1N0M2eVNuSm0vako5ZWs5UzMzK1JzY0lsTHIwSmYvWT0=",{"id":467,"name":468,"email":469,"is_corresponding":6,"orcid_link":470,"author_mark":266,"sp_link":471},309134,"Saeid Ghavami","saeid.ghavami@umanitoba.ca","https://orcid.org/0000-0001-5948-508X","https://sciprofiles.com/profile/134198",{"manuscript_id":473,"manuscript_version":7,"hash_key":474,"id":475,"version":7,"voted":47,"votes":476,"article_title":477,"article_abstract":478,"article_keywords":479,"top_subject_name":59,"subject_name":413,"article_type_name":314,"published_at":480,"download_url":481,"rank":53,"authors":482},"202301.0264","421f15bb4029d40b83f5bd0d34dd7658",69,51,"Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy","Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides’ fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the development of new treatments to activate or inhibit a single type of ceramide synthase, thereby regulating the apoptosis induction or cross talk of apoptosis and autophagy in cancer cells. Moreover, the apoptotic function of ceramide suggests that ceramide analogues can pave the way for the development of novel cancer treatments. Therefore, in the current review paper we discuss the impact of ceramide synthases and ceramides in regulation of apoptosis and autophagy in context of different types of cancers. We also briefly introduce the latest methods to analyze the lipids in biological samples. Finally, we discuss the drug development strategies focusing on the ceramide synthases and ceramides as future therapeutic approaches in cancer therapy.","mitochondrial cell death; autophagy cell death; lipidomic analysis; drug development","2023-01-16 03:37:34","/frontend/manuscript/421f15bb4029d40b83f5bd0d34dd7658/download_pub",[483,485,491,496,501,503,505,510,516,521],{"id":484,"name":419,"email":420,"is_corresponding":47,"orcid_link":421,"author_mark":148,"sp_link":422},311016,{"id":486,"name":487,"email":488,"is_corresponding":47,"orcid_link":489,"author_mark":148,"sp_link":490},311017,"Simone C. Da Silva Rosa","simone.dasilvarosa@umanitoba.ca","https://orcid.org/0000-0002-3732-3781","https://sciprofiles.com/profile/2622522",{"id":492,"name":493,"email":494,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":495},311018,"Xiaohui Weng","xweng5@csu.fullerton.edu","https://sciprofiles.com/profile/author/eVpFcFlBUVdlakhFcHcyekhqdDNaaGRiZlRqR21CamNCTkhneHV5UWtyMD0=",{"id":497,"name":498,"email":499,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":500},311019,"Joadi Jacobs","jacobsj1@myumanitoba.ca","https://sciprofiles.com/profile/author/MmVhMk0ySVlZeEtkSHgwNGVrRmVtbitmU3NhRHVibUxWSkxsMDRpMTF5bz0=",{"id":502,"name":436,"email":437,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":438},311020,{"id":504,"name":441,"email":442,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":443},311021,{"id":506,"name":507,"email":508,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":509},311022,"Rui Vitorino","ruimpvitorino@gmail.com","https://sciprofiles.com/profile/author/MzBsLzBzK05rTTUwd2RFSWRiNVZ0TUxRZ2VZNzRESkVtcTdoUGZmcXlUND0=",{"id":511,"name":512,"email":513,"is_corresponding":47,"orcid_link":514,"author_mark":148,"sp_link":515},311023,"Stevan Pecic","specic@fullerton.edu","https://orcid.org/0000-0002-3706-8768","https://sciprofiles.com/profile/999674",{"id":517,"name":518,"email":519,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":520},311024,"Shahla Shojaei","shahla.shojaei@umanitoba.ca","https://sciprofiles.com/profile/author/Q2tzaThsZzFFZWIwREhtL1FBQmNwcGR5dWRYRk1UMWxFWEx4ckZDMTZIcz0=",{"id":522,"name":468,"email":469,"is_corresponding":6,"orcid_link":470,"author_mark":266,"sp_link":471},311025,{"manuscript_id":524,"manuscript_version":7,"hash_key":525,"id":526,"version":7,"voted":47,"votes":527,"article_title":528,"article_abstract":529,"article_keywords":530,"top_subject_name":59,"subject_name":313,"article_type_name":140,"published_at":531,"download_url":532,"rank":53,"authors":533},"202304.0096","1bd0e364e570d11fbb692534b72f7a6f",61,26,"Efficient Purification of Polyhistidine-Tagged Recombinant Proteins Using Functionalized Corundum Particles","Immobilized metal affinity chromatography (IMAC) is a popular and valuable method for the affinity purification of polyhistidine-tagged recombinant proteins. However, it often shows practical limitations, which might require cumbersome optimizations, additional polishing, and enrichment steps. Here, we present functionalized corundum particles for the efficient, economical, and fast purification of recombinant proteins in a column-free format. The corundum surface is first derivatized with the amino silane APTES, then EDTA dianhydride, and subsequently loaded with nickel ions. The Kaiser test, well-known in solid-phase peptide synthesis, was used to monitor amino silanization and the reaction with EDTA dianhydride. In addition, ICP-MS was performed to quantify the metal-binding capacity. His-tagged protein A/G (PAG), mixed with bovine serum albumin (BSA), was used as a test system. The PAG binding capacity was around 3 mg protein per gram of corundum. Cytoplasm obtained from different E. coli strains was examined as an example of a complex matrix. The imidazole concentration was varied in the loading and washing buffers. As expected, higher imidazole concentrations during loading are usually beneficial when higher purities are desired. Even when higher sample volumes, such as one liter, were used, recombinant protein down to a concentration of 1 µg/mL could be isolated selectively. Comparing the corundum material with standard Ni-NTA agarose beads indicated higher purities of proteins isolated using corundum. His6-MBP-mSA2, a fusion protein consisting of monomeric streptavidin and maltose-binding protein in the cytoplasm of E. coli, was purified successfully. To show that this method is also suitable for mammalian cell culture supernatants, purification of the SARS-CoV-2-S-RBD His8 expressed in human Expi293F cells was performed. The material cost of the nickel-loaded corundum material (without regeneration) is estimated to be less than 30 cents for 1 gram of functionalized support or 10 cents per milligram of isolated protein. Another advantage of the novel system is the corundum particles' extremely high physical and chemical stability. The new material should be applicable in small laboratories and large-scale industrial applications. In summary, we could show that this new material is an efficient, robust, and cost-effective purification platform for the purification of His-tagged proteins, even in challenging, complex matrices and large sample volumes of low product concentration.","aluminum oxide; sapphire; ethylenediaminetetraacetic acid; nickel chelate; EDTAD; protein affinity enrichment; hexaHis-Tag; his6; 6xHis; his8; bioseparation; IMAC purification; immunocapture; enrichment; affinity chromatography; solid phase; carrier; material; corundum; nickel; recombinant protein; Escherichia coli; bacterial lysates; protein A/G; cytoplasm","2023-04-06 12:37:55","/frontend/manuscript/1bd0e364e570d11fbb692534b72f7a6f/download_pub",[534,539,544,549,554,559,564,569,575],{"id":535,"name":536,"email":537,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":538},324449,"Jule L. Völzke","jule.voelzke@bam.de","https://sciprofiles.com/profile/author/ZEpmdkdPbG40WGF6SjJNdHo4RlNIR2tQcEJBWmQ1M3EwSk9BbnBTdU1RRT0=",{"id":540,"name":541,"email":542,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":543},324450,"Sarah Smatty","sarah.smatty@bam.de","https://sciprofiles.com/profile/author/Y2xNcXhqbWNBZkNMeDUveHVSOGdud01tUnZCYi9jMlpjNjM1V1lNb2VUQT0=",{"id":545,"name":546,"email":547,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":548},324451,"Sarah Döring","sarah.doering@bam.de","https://sciprofiles.com/profile/2910702",{"id":550,"name":551,"email":552,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":553},324452,"Shireen Ewald","shireen.ewald@bam.de","https://sciprofiles.com/profile/author/N25wdTFjMFFqcFI1RUhCUDkrK1R1NncwU1lmb3kxbHdhR1JRSlN4L2FiZz0=",{"id":555,"name":556,"email":557,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":558},324453,"Marcus Oelze","marcus.oelze@bam.de","https://sciprofiles.com/profile/author/ZDVZMkovaUo2bStGYWFxaGFJYTlvazlGSldoSURmU0lJUTRENDVHbDNPdz0=",{"id":560,"name":561,"email":562,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":563},324454,"Franziska Fratzke","franziska.fratzke@bam.de","https://sciprofiles.com/profile/author/QlJaS0M1UTBQRGZseU1ZZ3ZUNE0wZGZhSFVMN1N3d2NQR3NJRHRjQXoxOD0=",{"id":565,"name":566,"email":567,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":568},324455,"Sabine Flemig","sabine.flemig@bam.de","https://sciprofiles.com/profile/author/L3FUdnJvWXRka1BaMUxqSWlORVdsbjIxMlZRZnJxaWNMaWhxR0x1bnZkQT0=",{"id":570,"name":571,"email":572,"is_corresponding":47,"orcid_link":573,"author_mark":148,"sp_link":574},324456,"Zoltán Konthur","zoltan.konthur@bam.de","https://orcid.org/0000-0002-8767-9823","https://sciprofiles.com/profile/1677565",{"id":576,"name":577,"email":578,"is_corresponding":6,"orcid_link":579,"author_mark":266,"sp_link":580},324457,"Michael G. Weller","michael.weller@bam.de","https://orcid.org/0000-0003-2767-2029","https://sciprofiles.com/profile/8355",{"manuscript_id":582,"manuscript_version":270,"hash_key":583,"id":584,"version":270,"voted":47,"votes":585,"article_title":586,"article_abstract":587,"article_keywords":588,"top_subject_name":59,"subject_name":589,"article_type_name":140,"published_at":590,"download_url":591,"rank":53,"authors":592},"202301.0275","6e703b505242c557b763a81dd4462589",67,10,"From Problem to Progress: Management of Rodents in Urban and Agricultural Settings in Sub-Saharan Africa","The prevalent use of synthetic chemical rodenticides (both 1st or 2nd generation anticoagulants and acute rodenticides) is the primary method for managing rodents in sub-Saharan Africa. However, this practice poses substantial health and environmental risks and often fails to yield significant, sustainable reductions in rodent pest populations. In this paper, the second one of a two-part series, we advocate for a more responsible and sustainable approach to rodent management in urban and agricultural settings in sub-Saharan Africa. We propose a shift towards environmentally friendly rodent management strategies, specifically emphasizing the adoption of Ecologically-Based Rodent Management (EBRM) as a viable alternative to synthetic chemical rodenticides. EBRM relies on a comprehensive understanding of pest rodent biology, ecology, and behavior, along with the implementation of a range of community-based interventions. These actions are designed to ensure the consistent reduction of rodent pest populations to economically and hygienically acceptable levels. By embracing EBRM, we not only anticipate a reduction in the social impacts of pest rodents in a cost-effective manner but also a significant decrease in the risks posed by rodents and synthetic chemical rodenticides to human health and the environment. This paradigm shift towards EBRM promises a more sustainable and responsible approach to rodent management in sub-Saharan Africa.","Africa; ecologically based rodent management; field rodents; pest management; rodent control; rodenticides; rodents; synanthropic rodents","Agricultural Science and Agronomy","2023-12-07 10:36:20","/frontend/manuscript/6e703b505242c557b763a81dd4462589/download_pub",[593,599,604,609,614,619,624,629,634,639,644,649,654,659,664,669,674,679,684,689],{"id":594,"name":595,"email":596,"is_corresponding":6,"orcid_link":597,"author_mark":266,"sp_link":598},435639,"Ambroise Dalecky","ambroise.dalecky@ird.fr","https://orcid.org/0000-0002-5075-4121","https://sciprofiles.com/profile/823618",{"id":600,"name":601,"email":602,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":603},435640,"Ibrahima Sow","sow.ibrahima9@ugb.edu.sn","https://sciprofiles.com/profile/author/VGdlVlhEY21IS0kxK1FFZWE3QklUSHZKYm1XMi9pc3FacHlLY0IxMk5vQT0=",{"id":605,"name":606,"email":607,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":608},435641,"Abdoul Aziz Ibrahim Danzabarma","az.danzabarma@gmail.com","https://sciprofiles.com/profile/author/bkxoZUFxaVJ1bnZpRzFPRVNUK1VyN1BqMXFjb0V0ajJKTmZYN1lhalVnST0=",{"id":610,"name":611,"email":612,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":613},435642,"Madougou Garba","garba_madougou@yahoo.fr","https://sciprofiles.com/profile/author/eGxMWmRQNFlpbFVPWGJLT0JtdzhaSGt3ZGhlWElrWVZISWg1THNVYS9SYz0=",{"id":615,"name":616,"email":617,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":618},435643,"Jonas Etougbetche","jonas.etougbetche@gmail.com","https://sciprofiles.com/profile/839439",{"id":620,"name":621,"email":622,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":623},435644,"Sylvestre Badou","sylvestre.badou@gmail.com","https://sciprofiles.com/profile/author/Vi91R3lKQ2RHMnpoSGdxV29YL3ROb2NrL2kwb1lXWW50akx3WnVsSVlBST0=",{"id":625,"name":626,"email":627,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":628},435645,"Henri-Joël Dossou","dossou_hjoel@yahoo.fr","https://sciprofiles.com/profile/3395538",{"id":630,"name":631,"email":632,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":633},435646,"Cheikh Tidiane Niang","niangcheikhtidiane@yahoo.fr","https://sciprofiles.com/profile/author/Wmp4K2o5ZTA5cnFsaHFjT3NxaEFDSDVkMHFJWEVXaTd4UkVTRWY1TmVqcz0=",{"id":635,"name":636,"email":637,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":638},435647,"Ousmane Diene","odiene16@yahoo.com","https://sciprofiles.com/profile/author/bllNOTlJWTczNGo1YnNNMEhCbkd5TDlQRDRDclF3NVVaNGZuWTlVZ3RqWT0=",{"id":640,"name":641,"email":642,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":643},435648,"Idrissa Diallo","diallorh@yahoo.fr","https://sciprofiles.com/profile/author/Y3pYeEl3VURkWEZQZ3kvWGltUEk3b0Z4ZXVkdlVHOTN4eU9oNWtoYi9RUT0=",{"id":645,"name":646,"email":647,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":648},435649,"Mohamed Seyidna Ali Saghiri","msa.saghiri@gmail.com","https://sciprofiles.com/profile/author/WjBOTkM2RnNCcC9SRUVJbUhxWGtRdDJleURiOFRsU3RiYjE2QjdTbElnST0=",{"id":650,"name":651,"email":652,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":653},435650,"Mohamed El Hady Sidatt","mohamedelhady.sidatt@fao.org","https://sciprofiles.com/profile/author/MlVybzkwbXdBTy9wTU45T0ZEV1B3ZURYdE5oblE2T2lCKyt4eVc1STRIbz0=",{"id":655,"name":656,"email":657,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":658},435651,"Frank Van Steenbergen","fvansteenbergen@metameta.nl","https://sciprofiles.com/profile/123744",{"id":660,"name":661,"email":662,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":663},435652,"Amadou Bocar Bal","amadou-bocar.bal@ugb.edu.sn","https://sciprofiles.com/profile/author/eDc4WkhIbHJnYSswWXREY3hNU0txaFRNaklnZytyb3NrdExoeFQ0bUwwND0=",{"id":665,"name":666,"email":667,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":668},435653,"Luwieke Bosma","lbosma@metameta.nl","https://sciprofiles.com/profile/author/RFRhR0FmK0NwdmhLWmFENEZjT3ZwYTlzc242cmhiRUhFRTBYK0toOGkvOD0=",{"id":670,"name":671,"email":672,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":673},435654,"Gualbert Houemenou","gualbert.houemenou@gmail.com","https://sciprofiles.com/profile/author/QnNOVnNoU2MrWEcrQ1B4b2d1Nm5zWTM5NGJCYm8rUlNLVlR5M28yQlZ5QT0=",{"id":675,"name":676,"email":677,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":678},435655,"Solimane Ag Atteynine","solimane.ag-atteynine@ird.fr","https://sciprofiles.com/profile/author/NU5Sb2llT0xQSEt4NE5HNmZMWWlyMjZUWkVTNGhiSzMxZmVibFpiZnR1ND0=",{"id":680,"name":681,"email":682,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":683},435656,"Karmadine Hima","karmadine@gmail.com","https://sciprofiles.com/profile/822538",{"id":685,"name":686,"email":687,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":688},435657,"Gauthier Dobigny","gauthier.dobigny@ird.fr","https://sciprofiles.com/profile/400521",{"id":690,"name":691,"email":692,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":693},435658,"Yonas Meheretu","yonas.meheretu@slu.se","https://sciprofiles.com/profile/3606727",{"manuscript_id":695,"manuscript_version":7,"hash_key":696,"id":697,"version":7,"voted":47,"votes":5,"article_title":698,"article_abstract":699,"article_keywords":700,"top_subject_name":59,"subject_name":701,"article_type_name":140,"published_at":702,"download_url":703,"rank":53,"authors":704},"202310.1622","b9f5b175b599e2d6d2e48b749f6aa4fe",62,"Engineering a Novel Modular Adenoviral mRNA Delivery Platform Based on Tag/Catcher Bioconjugation","mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for personalization. However, current mRNA vaccine platforms have not been optimized for induction of CD4/CD8 T cell responses. In addition, mucosal administration of mRNA based on lipid nanoparticle technology faces challenges in clinical translation. In contrast, adenovirus-based vaccines induce strong T-cell responses and have been approved for intranasal delivery. To leverage the inherent strengths of both the mRNA and adenovirus platforms, we developed a novel modular adenoviral mRNA delivery platform based on Tag/Catcher bioconjugation. Specifically, we engineered adenoviral vectors integrating Tag/Catcher proteins at specific locales on the Ad capsid proteins, allowing us to anchor mRNA to the surface of engineered Ad viruses. In proof-of-concept studies, the Ad-mRNA platform successfully mediated mRNA delivery and could be optimized via the highly flexible modular design of both the Ad-mRNA and protein bioconjugation systems.","mRNA delivery; adenovirus; Catcher/Tag bioconjugation; RNA binding protein; mRNA condensation; vaccine","Virology","2023-10-25 10:31:41","/frontend/manuscript/b9f5b175b599e2d6d2e48b749f6aa4fe/download_pub",[705,711,716,721,727,732,737,742],{"id":706,"name":707,"email":708,"is_corresponding":47,"orcid_link":709,"author_mark":148,"sp_link":710},416409,"Kexin Geng","g.kexin@wustl.edu","https://orcid.org/0009-0004-9240-7736","https://sciprofiles.com/profile/2647375",{"id":712,"name":713,"email":714,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":715},416410,"Paul J. Rice-Boucher","pboucher@wustl.edu","https://sciprofiles.com/profile/author/VzVWWm5mbGpXM1d5L05mSS9HZW9SNzE0Q1d5K3FYU0pDcEpGeitsSzJEQT0=",{"id":717,"name":718,"email":719,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":720},416411,"Elena A. Kashentseva","ekashentseva@wustl.edu","https://sciprofiles.com/profile/author/MG1PTENjZjFocXpuenBRRFExK1psdTlqMlNzUGxRNlBsL1NYVmFjclM1VT0=",{"id":722,"name":723,"email":724,"is_corresponding":47,"orcid_link":725,"author_mark":148,"sp_link":726},416412,"Igor P. Dmitriev","idmitriev@wustl.edu","https://orcid.org/0000-0001-9206-1975","https://sciprofiles.com/profile/3269951",{"id":728,"name":729,"email":730,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":731},416413,"Zhihong Lu","zhihonglu@wustl.edu","https://sciprofiles.com/profile/author/TVMvMnYwYU9GQ1drZllkYTZXaUVVR01mRTg3QmRVUjNEaWlRZ210SjZsOD0=",{"id":733,"name":734,"email":735,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":736},416414,"S. Peter Goedegebuure","goedegep@wustl.edu","https://sciprofiles.com/profile/16668",{"id":738,"name":739,"email":740,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":741},416415,"William E. Gillanders","gillandersw@wustl.edu","https://sciprofiles.com/profile/author/eWpPWGtPUDNtRTA0eitzZXphclBVVGNScG94dzRXQ0d1bGNVRENFUklJcz0=",{"id":743,"name":744,"email":745,"is_corresponding":6,"orcid_link":746,"author_mark":266,"sp_link":747},416416,"David T. Curiel","dcuriel@wustl.edu","https://orcid.org/0000-0003-3802-6014","https://sciprofiles.com/profile/12139",{"manuscript_id":749,"manuscript_version":7,"hash_key":750,"id":751,"version":7,"voted":47,"votes":752,"article_title":753,"article_abstract":754,"article_keywords":755,"top_subject_name":59,"subject_name":277,"article_type_name":314,"published_at":756,"download_url":757,"rank":53,"authors":758},"202310.1646","f409f09ce63874d94b5a852cda2961dc",66,6,"Nonequilibrium Dynamics in Conservation Biology: Scales, Attractors and Critical Points","Preserving and restoring biodiversity is becoming a great challenge as we face a world where planetary boundaries will likely be crossed over the following decades. Such challenge needs to consider multiple scales of complexity, both in space and time. A common thread in most cases is the presence of nonlinear phenomena generating shifts among alternative states. These breaking points imply a new perception of risk and different management strategies. A broad range of phenomena affect the preservation of healthy communities and constrain the ways to deal with conservation, from local features associated with habitat loss or facilitation to mesoscale or global network-level ecological complexity and the role played by extreme events. How are these scales connected? How can the emergent properties associated with ecosystem dynamics be exploited? Here a synthesis of ideas is presented, with a complex systems view of the different scales involved, the emergent phenomena separating them, and the universal properties that allow defining simple models on each scale.\u003Cspan> \u003C/span>","Scaling laws; biodiversity; habitat loss; ecological networks; tipping points","2023-10-26 03:41:36","/frontend/manuscript/f409f09ce63874d94b5a852cda2961dc/download_pub",[759],{"id":760,"name":761,"email":762,"is_corresponding":6,"orcid_link":763,"author_mark":266,"sp_link":764},413667,"Ricard Sole","ricard.sole@upf.edu","https://orcid.org/0000-0001-6974-1008","https://sciprofiles.com/profile/350394",{"category":73,"manuscripts":766},[767,814,858,930,953,981,1031,1060,1088,1120],{"manuscript_id":768,"manuscript_version":7,"hash_key":769,"id":770,"version":7,"voted":47,"votes":771,"article_title":772,"article_abstract":773,"article_keywords":774,"top_subject_name":73,"subject_name":775,"article_type_name":140,"published_at":776,"download_url":777,"rank":7,"authors":778},"202306.1846","bde20c885146e67fad68c2ab44af7aff",57,349,"Metabolome Mining of Curcuma longa L. Using HPLC-MS/MS and Molecular Networking","Turmeric, Curcuma longa L., is a type of medicinal plant characterized by its perennial nature and rhizomatous growth. It is a member of the Zingiberaceae family and is distributed across the world’s tropical and subtropical climates, especially in South Asia. Its rhizomes are highly valued for food supplements, spices, flavoring agents, and yellow dye in South Asia since ancient times. It exhibits a diverse array of therapeutic qualities that encompass its ability to combat diabetes, reduce inflammation, act as an antioxidant, exhibit anticancer properties, and promote anti-aging effects. In this study, organic extracts of C. longa rhizomes were subjected to HPLC separation followed by mass spectrometry analysis. The Global Natural Product Social Molecular Networking (GNPS) approach was utilized for the first time in this ethnobotanically important species to conduct an in-depth analysis of its metabolomes based on their fragments. A total of 30 metabolites including 16 diarylheptanoids, 1 diarylpentanoid, 3 bisabolocurcumin ethers, 4 sesquiterpenoids, 4 cinnamic acid derivatives, and 2 fatty acid derivatives were identified. Among 16 diarylheptanoids identified in this study, five of them are reported for the first time in this species.","Untargeted metabolomics; HPLC-ESI-MS/MS; Curcuma longa; GNPS; Diarylheptanoids","Analytical Chemistry","2023-06-27 04:47:44","/frontend/manuscript/bde20c885146e67fad68c2ab44af7aff/download_pub",[779,785,791,796,802,808],{"id":780,"name":781,"email":782,"is_corresponding":47,"orcid_link":783,"author_mark":148,"sp_link":784},360615,"Rabin Budhathoki","rabin.bc.992@gmail.com","https://orcid.org/0009-0001-9116-366X","https://sciprofiles.com/profile/3022336",{"id":786,"name":787,"email":788,"is_corresponding":47,"orcid_link":789,"author_mark":148,"sp_link":790},360616,"Arjun Prasad Timilsina","arzun1777@gmail.com","https://orcid.org/0000-0003-3131-390X","https://sciprofiles.com/profile/1689761",{"id":792,"name":793,"email":794,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":795},360617,"Bishnu P. Regmi","bishnu1regmi@gmail.com","https://sciprofiles.com/profile/102446",{"id":797,"name":798,"email":799,"is_corresponding":47,"orcid_link":800,"author_mark":148,"sp_link":801},360618,"Khaga Raj Sharma","khagaraj_sharma33@yahoo.com","https://orcid.org/0000-0002-1555-0887","https://sciprofiles.com/profile/1051730",{"id":803,"name":804,"email":805,"is_corresponding":6,"orcid_link":806,"author_mark":266,"sp_link":807},360619,"Niraj Aryal","niraj.aryal@ufl.edu","https://orcid.org/0000-0001-6145-9657","https://sciprofiles.com/profile/3022294",{"id":809,"name":810,"email":811,"is_corresponding":6,"orcid_link":812,"author_mark":266,"sp_link":813},360620,"Niranjan Parajuli","niranjan.parajuli@cdc.tu.edu.np","https://orcid.org/0000-0002-9233-6489","https://sciprofiles.com/profile/1068910",{"manuscript_id":815,"manuscript_version":7,"hash_key":816,"id":817,"version":7,"voted":47,"votes":818,"article_title":819,"article_abstract":820,"article_keywords":821,"top_subject_name":73,"subject_name":822,"article_type_name":314,"published_at":823,"download_url":824,"rank":280,"authors":825},"202308.1912","5e2e22c3460c0633085c307652c2c136",53,230,"Polymers in 3D Printing of External Maxillofacial Prostheses and Their Retention Systems","Maxillofacial defects, arising from trauma, oncological disease or congenital differences, detrimentally affect everyday life. Prosthetic repair offers the aesthetic and functional reconstruction with the help of materials mimicking natural tissues, among which polymers take unprecedented role. The three-dimensional (3D) printing techniques based on the computer-aided design, where polymers are essential, provide a rapid and cost-effective workflow protocol to perfectly restore patient-specific anatomy for prosthetics. This review discusses the main 3D printing approaches to maxillofacial prostheses fabrication: extrusion and lithography, which are radically preferable to the traditional methods. The main assessment criteria, affording the polymer implementation in 3D printing of prostheses, as well as the characteristics of the key advanced polymers, are considered. The success of the prosthesis is shown to be largely dependent on the retention system, predominantly using polymers in the form of adhesives and osseointegrated implants as a support for the prosthesis. The approaches and technological prospects are also discussed in the context of specific aesthetic restoration on the example of the nasal, auricle and ocular prostheses. 3D printing techniques determine the development of personalized approaches to improve aesthetic and functional effect of prosthetics in patients with maxillofacial defects.","3D printing; polymers for maxillofacial prostheses; adhesives; osseointegrated implants; nasal; auricle and ocular prostheses","Medicinal Chemistry","2023-08-29 03:30:06","/frontend/manuscript/5e2e22c3460c0633085c307652c2c136/download_pub",[826,832,837,842,848,853],{"id":827,"name":828,"email":829,"is_corresponding":47,"orcid_link":830,"author_mark":148,"sp_link":831},390044,"Samvel V. Apresyan","dr.apresyan@gmail.com","https://orcid.org/0000-0002-3281-707X","https://sciprofiles.com/profile/3536310",{"id":833,"name":834,"email":835,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":836},390045,"Alexandr G. Stepanov","stepanovmd@list.ru","https://sciprofiles.com/profile/author/RkZIVVJCemhFdDkrYnNOdzNSNWpTMmY2b0JXam9yS2pSclJZVFFpVCsvcz0=",{"id":838,"name":839,"email":840,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":841},390046,"Alexander A. Vikhrov","sorb9@mail.ru","https://sciprofiles.com/profile/author/VGMzR0pJODMrSEJlRWU4aEtubDBqQT09",{"id":843,"name":844,"email":845,"is_corresponding":47,"orcid_link":846,"author_mark":148,"sp_link":847},390047,"Maxim S. Myasoedov","papuguain@gmail.com","https://orcid.org/0009-0007-3510-0529","https://sciprofiles.com/profile/3122479",{"id":849,"name":850,"email":851,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":852},390048,"Anna I. Prostyakova","prostyakova@gmail.com","https://sciprofiles.com/profile/author/cXE2aDJ1eGVERXpSU0hIZVRuRHllNXVQTWw5aFBhRURPeGhaOUp1ajZxbz0=",{"id":854,"name":855,"email":856,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":857},390049,"Alla N. Generalova","angeneralova@gmail.com","https://sciprofiles.com/profile/2935708",{"manuscript_id":859,"manuscript_version":7,"hash_key":860,"id":861,"version":7,"voted":47,"votes":862,"article_title":863,"article_abstract":864,"article_keywords":865,"top_subject_name":73,"subject_name":866,"article_type_name":314,"published_at":867,"download_url":868,"rank":53,"authors":869},"202310.1491","11e05f7d0db892cc1f0023734ba95545",52,139,"Polysaccharide-Based Bioplastics as Green and Sustainable Packaging Materials","Over the past few decades, synthetic polymer production has increased, and the production of plastics has surpassed all other man-made materials due to their versatility. Moreover, packaging plastic makes up around 40% of global plastic production. However, the excessive usage of synthetic packaging materials has led to severe environmental and health-related issues. Therefore, biobased packages are considered alternatives to substitute synthetic packaging on the market. Furthermore, the choice of packing material in the food industry is a perplexing process as it depends on various factors, such as the type of food product, its sustainability, and environmental conditions. Interestingly, due to proven gas barrier properties and biological activity, polysaccharide-based bioplastics show the potential to expand the trends in food packaging, including edible films and intelligent and active food packaging. This review discusses the structure, properties and recent developments in polysaccharide-based bioplastics as food packaging materials.","Active packaging; Alginates; Bioplastics; Carrageenan; Cellulose; Chitin; Chitosan; Food packaging; Gellan gum; Polysaccharides; Starch","Surfaces, Coatings and Films","2023-10-24 08:16:38","/frontend/manuscript/11e05f7d0db892cc1f0023734ba95545/download_pub",[870,876,882,888,893,899,904,909,914,919,925],{"id":871,"name":872,"email":873,"is_corresponding":6,"orcid_link":874,"author_mark":266,"sp_link":875},415058,"Ashoka Gamage","ashogamage@gmail.com","https://orcid.org/0000-0001-5576-8330","https://sciprofiles.com/profile/1545067",{"id":877,"name":878,"email":879,"is_corresponding":47,"orcid_link":880,"author_mark":148,"sp_link":881},415059,"Punniamoorthy Thiviya","thiviya904@gmail.com","https://orcid.org/0000-0001-6980-5155","https://sciprofiles.com/profile/1971064",{"id":883,"name":884,"email":885,"is_corresponding":47,"orcid_link":886,"author_mark":148,"sp_link":887},415060,"Anuradhi Liyanapathiranage","anuradhi.liyanapathiranage@gmail.com","https://orcid.org/0000-0002-1378-6829","https://sciprofiles.com/profile/2228051",{"id":889,"name":890,"email":891,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":892},415061,"M.L.D. Wasana","mldwasana@gmail.com","https://sciprofiles.com/profile/3210350",{"id":894,"name":895,"email":896,"is_corresponding":47,"orcid_link":897,"author_mark":148,"sp_link":898},415062,"Yasasvi Jayakodi","yujayakodi@gmail.com","https://orcid.org/0000-0001-5150-117X","https://sciprofiles.com/profile/3032576",{"id":900,"name":901,"email":902,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":903},415063,"Amith Bandara","amithb@pdn.ac.lk","https://sciprofiles.com/profile/author/dFl1S0ZYNXJLYkVKV1d3MGJzYi9USGhJOHgrUDRxdnFmMFM5dkxmRTJFZz0=",{"id":905,"name":906,"email":907,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":908},415064,"Asanga Manamperi","amanamperi@kettering.edu","https://sciprofiles.com/profile/2548458",{"id":910,"name":911,"email":912,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":913},415065,"Rohan S. Dassanayake","rdassanayake@sjp.ac.lk","https://sciprofiles.com/profile/525831",{"id":915,"name":916,"email":917,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":918},415066,"Philippe Evon","philippe.evon@ensiacet.fr","https://sciprofiles.com/profile/1166420",{"id":920,"name":921,"email":922,"is_corresponding":6,"orcid_link":923,"author_mark":266,"sp_link":924},415067,"Othmane Merah","othmane.merah@ensiacet.fr","https://orcid.org/0000-0002-9863-150X","https://sciprofiles.com/profile/278321",{"id":926,"name":927,"email":928,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":929},415068,"Terrence Madhujith","tmadhujith@agri.pdn.ac.lk","https://sciprofiles.com/profile/1876654",{"manuscript_id":931,"manuscript_version":7,"hash_key":932,"id":933,"version":7,"voted":47,"votes":934,"article_title":935,"article_abstract":936,"article_keywords":937,"top_subject_name":73,"subject_name":938,"article_type_name":314,"published_at":939,"download_url":940,"rank":53,"authors":941},"202310.1999","869ec3ecf27f64975542772b812e3776",58,60,"The Next Frontier in Energy Storage: A Game-Changing Guide to Advances in Solid-State Battery Cathodes","As the global community shifts away from fossil fuels towards more environmentally friendly energy alternatives, there is an escalating demand for sophisticated energy storage solutions. Solid-State Batteries (SSBs) have emerged as a promising advancement, presenting a superior substitute to conventional lithium-ion batteries. This review provides an in-depth examination of SSBs, emphasizing their enhanced energy density, safety, and longevity. We evaluate conventional cathode materials, including lithium cobalt oxide (LiCoO2), lithium manganese oxide (LiMn2O4), and lithium iron phosphate (LiFePO4). Additionally, we introduce emerging materials such as sulfides, oxides, and air-based cathodes, discussing their benefits, limitations, and their congruence with solid electrolytes. Special attention is devoted to the structural fine-tuning of cathode ma-terials, investigating approaches like nanostructuring, surface coatings, and composite strategies to counteract issues such as restricted conductivity and structural volatility. The review critically analyzes the electrical and thermal properties of these materials, which are essential for battery safety and efficacy. Moreover, we present a comparative assessment of cathode materials based on performance indicators and identify prevailing research voids and hurdles in the commerciali-zation of SSB cathodes. Concluding, we suggest prospective research directions and innovations, underscoring the revolutionary potential of SSB technologies in paving the way for a sustainable energy horizon.","Solid-State Batteries, Cathode Materials, Energy Density","Materials Science and Technology","2023-10-31 06:11:06","/frontend/manuscript/869ec3ecf27f64975542772b812e3776/download_pub",[942,948],{"id":943,"name":944,"email":945,"is_corresponding":6,"orcid_link":946,"author_mark":266,"sp_link":947},418621,"Abniel Machín","machina1@uagm.edu","https://orcid.org/0000-0003-4134-3344","https://sciprofiles.com/profile/1159544",{"id":949,"name":950,"email":951,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":952},418622,"Francisco Márquez","fmarquez@uagm.edu","https://sciprofiles.com/profile/29359",{"manuscript_id":954,"manuscript_version":7,"hash_key":955,"id":956,"version":7,"voted":47,"votes":957,"article_title":958,"article_abstract":959,"article_keywords":960,"top_subject_name":73,"subject_name":961,"article_type_name":314,"published_at":962,"download_url":963,"rank":53,"authors":964},"202305.0832","a78a670c54a53b3a3fc706fc37ae60c2",55,36,"Bioactive Calcium Phosphate Coatings for Bone Implant Applications: A Review","This review article deals with the design of bioactive calcium phosphate coatings deposited on metallic substrates to produce bone implants. The bioceramic coating properties are used to create a strong bonding between the bone implants and the surrounding bone tissue. They provide a fast response after implantation and increase the lifespan of the implant in the body environment. The first part of the article describes the different compounds belonging to the calcium phosphate family and their main properties for applications in biomaterials science. The calcium to phosphorus atomic ratio (Ca/P)at. and the solubility (Ks) of these compounds define their behavior in a physiological environment. Hydroxyapatite is the gold standard among calcium phosphate materials, but other chemical compositions/stoichiometries have also been studied for their interesting properties. The second part reviews the most usual deposition processes to produce bioactive calcium phosphate coatings for bone implant applications. Plasma spraying is the main industrial process, but magnetron sputtering, pulsed laser deposition, electrospray deposition, electrophoretic deposition, and electrodeposition are also widely studied in academic and industrial research. The last part describes the main physicochemical properties of calcium phosphate coatings and their impact on the bioactivity of bone implants in a physiological environment.","biomaterials; coatings; calcium phosphates; hydroxyapatite; bone implant; biocompatibility; bioactivity; hard tissue repair","Biomaterials","2023-05-11 09:03:34","/frontend/manuscript/a78a670c54a53b3a3fc706fc37ae60c2/download_pub",[965,970,976],{"id":966,"name":967,"email":968,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":969},338367,"Richard Drevet","drevet@mail.muni.cz","https://sciprofiles.com/profile/568424",{"id":971,"name":972,"email":973,"is_corresponding":47,"orcid_link":974,"author_mark":148,"sp_link":975},338368,"Joël Fauré","joel.faure@univ-reims.fr","https://orcid.org/0000-0002-5002-6239","https://sciprofiles.com/profile/279220",{"id":977,"name":978,"email":979,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":980},338369,"Hicham Benhayoune","hicham.benhayoune@univ-reims.fr","https://sciprofiles.com/profile/222470",{"manuscript_id":982,"manuscript_version":7,"hash_key":983,"id":984,"version":7,"voted":47,"votes":985,"article_title":986,"article_abstract":987,"article_keywords":988,"top_subject_name":73,"subject_name":775,"article_type_name":140,"published_at":989,"download_url":990,"rank":53,"authors":991},"202306.2194","00089205ea4ceec485b229b02b71028c",56,21,"A Green Voltammetric Determination of Molnupiravir using a Disposable Screen-Printed Reduced Graphene Oxide Electrode: Application to Pharmaceutical Dosage Form and Biological Fluid","A new green-validated and highly sensitive electrochemical method for the determination of molnupiavir (MOV) has been developed using cyclic voltammetry. The proposed analytical platform involves the use of disposable screen-printed reduced graphene oxide 2.5% electrode (SPrGOE 2.5%) for the first time to measure MOV with high specificity. The surface morphology of the sensor was investigated by using a scanning electron microscope armed with an energy-dispersive X-ray probe. The fabricated sensor attains improved sensitivity when sodium dodecyl sulfate (SDS) surfactant was added to the supporting electrolyte solution. Thus, various factors were investigated in order to select the best supporting electrolyte for voltammetric determination of MOV, and the optimum conditions were achieved by employing 0.04 M Britton-Robinson at pH 2, 10-4 M SDS, and SPrGOE 2.5%. Well-defined MOV oxidation peaks were obtained with no reduction peaks in cyclic voltammetry using diffusion-controlled pathways. The method was validated using differential pulse voltammetry according to ICH guidelines, providing it to be precise, accurate, specific, and robust with linearity over a concentration range of 50-6017 ng/mL. The incorporation of the reduced graphene nanoparticles supported the in situ interaction between electrode surface and MOV, improved the selectivity, and reduced the detection limit to the concentration level of 15.98 ng/mL. The stability investigation demonstrated that SPrGOE 2.5% can provide high-stability behavior throughout a three-month period under refrigeration. The fabricated SPrGOE 2.5% was successfully employed for the measurement of MOV in pharmaceutical capsules and human bio-fluids without the interference of endogenous matrix components as well as the commonly used excipient.","Molnupiravir; cyclic voltammetry; differential pulse; disposable screen printed electrode; biological fluids; greenness assessment","2023-06-30 09:23:18","/frontend/manuscript/00089205ea4ceec485b229b02b71028c/download_pub",[992,997,1002,1008,1014,1019,1025],{"id":993,"name":994,"email":995,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":996},362362,"Abdelrahman Nabile","abdelrahman2081369@miuegypt.edu.eg","https://sciprofiles.com/profile/3050117",{"id":998,"name":999,"email":1000,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1001},362363,"Hassan Hendawy","hassanhendawy@yahoo.com","https://sciprofiles.com/profile/3522331",{"id":1003,"name":1004,"email":1005,"is_corresponding":47,"orcid_link":1006,"author_mark":148,"sp_link":1007},362364,"Randa Abdel Salam","dr_rasalam@yahoo.com","https://orcid.org/0000-0001-7554-3577","https://sciprofiles.com/profile/2516931",{"id":1009,"name":1010,"email":1011,"is_corresponding":47,"orcid_link":1012,"author_mark":148,"sp_link":1013},362365,"Rasha Ahmed","rasha_ahmed@miuegypt.edu.eg","https://orcid.org/0000-0001-8256-6582","https://sciprofiles.com/profile/1250178",{"id":1015,"name":1016,"email":1017,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1018},362366,"Ahmed Shawky","shawky0225@gmail.com","https://sciprofiles.com/profile/author/cUduVkNuOEx6dHBBWnkwRUZkQmtscWVaenJzUEZQZmJNdWJDc2YwaXFGUT0=",{"id":1020,"name":1021,"email":1022,"is_corresponding":6,"orcid_link":1023,"author_mark":266,"sp_link":1024},362367,"Samy Emara","sami.omara@miuegypt.edu.eg","https://orcid.org/0000-0002-9126-4858","https://sciprofiles.com/profile/2517954",{"id":1026,"name":1027,"email":1028,"is_corresponding":47,"orcid_link":1029,"author_mark":148,"sp_link":1030},362368,"Noha Ibrahim","noha.ibrahim@miuegypt.edu.eg","https://orcid.org/0000-0002-0584-3432","https://sciprofiles.com/profile/2949538",{"manuscript_id":1032,"manuscript_version":7,"hash_key":1033,"id":934,"version":7,"voted":47,"votes":1034,"article_title":1035,"article_abstract":1036,"article_keywords":1037,"top_subject_name":73,"subject_name":1038,"article_type_name":314,"published_at":1039,"download_url":1040,"rank":53,"authors":1041},"202309.2128","d0daf1c28626e67a2a69a09074eb97a0",19,"The Effect of Electrolyte on the Kinetics of Hydrogen Evolution Reaction","Amid global energy challenges, hydrogen evolution reaction (HER) is gaining traction for green hydrogen production. While catalyst research is ongoing, recognizing electrolyte effects remains crucial for sustainable hydrogen production via renewable-powered water electrolysis. This review delves into the intricate effects of electrolytes on the kinetics of HER. It examines key factors, including pH, cations, anions, impurities, and electrolyte concentration. It is discussed that electrolyte pH alters catalyst-electrolyte interactions and proton concentrations, thereby influencing factors such as hydrogen binding energy, water adsorption, and the overall reaction kinetics. Moreover, it is briefed that electrolyte cations, such as Li+, can impact HER positively or negatively, offering opportunities for improvement based on the metal substrate. Interestingly, there is a potential that HER can be tuned using Li+ ions to modify M-H bond energy, demonstrating flexibility beyond pH levels and counter ions. Varied adsorption energies of metal cations on metal electrodes are also found to influence HER kinetics. The effects of electrolyte anions and impurities are also discussed, emphasizing both positive and negative impacts on HER kinetics. Moreover, it is pointed out that the electrolyte engineering approach enhances the HER kinetics of both metal and carbon-based electrodes without permanent catalyst surface modifications. This review underscores the importance of electrolyte composition, highlighting both challenges and potential solutions in advancing HER research for sustainable energy production.","Hydrogen evolution reaction, kinetics; electrolyte; electrolyte ions; electrolyte impurities; electrolyte engineering","Electrochemistry","2023-10-03 03:13:04","/frontend/manuscript/d0daf1c28626e67a2a69a09074eb97a0/download_pub",[1042,1048,1054],{"id":1043,"name":1044,"email":1045,"is_corresponding":47,"orcid_link":1046,"author_mark":148,"sp_link":1047},405522,"Goitom K. Gebremariam","nebyat1997@gmail.com","https://orcid.org/0000-0003-2095-2474","https://sciprofiles.com/profile/3184255",{"id":1049,"name":1050,"email":1051,"is_corresponding":47,"orcid_link":1052,"author_mark":148,"sp_link":1053},405523,"Aleksandar Z. Jovanović","a.jovanovic@ffh.bg.ac.rs","https://orcid.org/0000-0003-1505-838X","https://sciprofiles.com/profile/3185523",{"id":1055,"name":1056,"email":1057,"is_corresponding":6,"orcid_link":1058,"author_mark":266,"sp_link":1059},405524,"Igor A Pašti","igor@ffh.bg.ac.rs","https://orcid.org/0000-0002-1000-9784","https://sciprofiles.com/profile/645521",{"manuscript_id":1061,"manuscript_version":7,"hash_key":1062,"id":1063,"version":7,"voted":47,"votes":1064,"article_title":1065,"article_abstract":1066,"article_keywords":1067,"top_subject_name":73,"subject_name":775,"article_type_name":140,"published_at":1068,"download_url":1069,"rank":53,"authors":1070},"202308.2086","2bcbf4022f60a2d06391ef9f99cf2409",59,12,"Greener and Whiter Analytical Chemistry Using Cyrene as a More Sustainable and Eco-Friendlier Mobile Phase Solvent in Chromatography","Cyrene was evaluated for the first time as a potential sustainable mobile phase solvent in re-versed-phase chromatography. As a benign biodegradable solvent, Cyrene is an attractive re-placement to classical non-green organic chromatographic solvents such as acetonitrile and a modifier, co-eluent to known green solvents such as ethanol. Compared to ethanol, Cyrene is less toxic, non-flammable, bio-based, biodegradable and cheaper solvent. A fire safety spider Chart was generated to compare the properties of Cyrene to ethanol and show its superiority as a greener solvent. Cyrene's behaviour, advantages, and drawbacks in reversed-phase chromatography, including cut-off value, elution power, selectivity, and effect on the column, were investigated using a model drug mixture of moxifloxacin and metronidazole. A monolithic C18 (10 x 4.6 mm) column was used as a stationary phase. Different ratios of Cyrene: ethanol with an aqueous portion of sodium acetate buffer mobile phases were tested. A mobile phase consisting of Cyrene: ethanol: 0.1 M sodium acetate buffer pH 4.25 (8:13:79, v/v) was selected as most suitable mobile phase system for separating and simultaneously determining metronidazole and moxifloxacin. The greenness and whiteness of the method were evaluated using the qualitative green assessment tool AGREE and the white analytical chemistry assessment tool RGB12. Further potentials of Cyrene as a solvent or modifier in normal phase chromatography, liquid chromatography-mass spectrometry, and supercritical fluid chromatography are discussed.","green analytical chemistry; white analytical chemistry; global climate change; sustibability; sus-tinable solvent; greeneess; Cyrene, RGB12; AGREE; RP-HPLC","2023-08-31 03:21:07","/frontend/manuscript/2bcbf4022f60a2d06391ef9f99cf2409/download_pub",[1071,1076,1082],{"id":1072,"name":1073,"email":1074,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1075},390708,"Sami El Deeb","s.eldeeb@tu-braunschweig.de","https://sciprofiles.com/profile/1403627",{"id":1077,"name":1078,"email":1079,"is_corresponding":47,"orcid_link":1080,"author_mark":148,"sp_link":1081},390709,"Khalid Abdelsamad","abdelsamak87@zedat.fu-berlin.de","https://orcid.org/0009-0001-4510-3949","https://sciprofiles.com/profile/3211780",{"id":1083,"name":1084,"email":1085,"is_corresponding":47,"orcid_link":1086,"author_mark":148,"sp_link":1087},390710,"Maria Kristina Parr","maria.parr@fu-berlin.de","https://orcid.org/0000-0001-7407-8300","https://sciprofiles.com/profile/352628",{"manuscript_id":1089,"manuscript_version":7,"hash_key":1090,"id":1091,"version":7,"voted":47,"votes":585,"article_title":1092,"article_abstract":1093,"article_keywords":1094,"top_subject_name":73,"subject_name":938,"article_type_name":314,"published_at":1095,"download_url":1096,"rank":53,"authors":1097},"202310.1164","8c0529dd6af0947b49a5906b55702872",54,"Green Synthesis of Metal and Metal Oxide Nanoparticles for Recent Applications","Green synthesis offers a superior alternative to traditional methods for producing metal and metal oxide nanoparticles. This approach is not only benign and safe but also cost-effective, scalable, and straightforward, operating under ambient conditions. Notable metals and metal oxide nanoparticles, such as manganese oxides, iron oxides, silver, and gold, have been produced using various bio-reductants derived from plant extracts. These biological agents not only expedite the reduction process but also stabilize the nanoparticles, serving dual roles as reducing and capping agents. This review presents the green synthesis of nanoparticles (NPs) obtained from biogenic wastes and plant extracts. The green-synthesized nanostructured MnO2 are evaluated as a potential photocatalyst for water treatment and as an electrode material in lithium-ion batteries and supercapacitors. The green-derived iron oxide nanoparticles are examined as promising antioxidant, anti-inflammatory, and anti-diabetic agents. Additionally, this review discusses the green synthesis of precious metal nanoparticles, specifically silver (Ag NPs) and gold (Au NPs), highlighting their potential medical applications in areas like antiviral treatments and cancer therapy.","Nanotechnology; Green synthesis; Metals; Bio-reductants; Lithium-ion batteries; Supercapacitors; Photocatalysts; Cancer therapy.","2023-10-18 12:27:03","/frontend/manuscript/8c0529dd6af0947b49a5906b55702872/download_pub",[1098,1104,1109,1115],{"id":1099,"name":1100,"email":1101,"is_corresponding":47,"orcid_link":1102,"author_mark":148,"sp_link":1103},413073,"Hanaa M Abuzeid","hanaa20619@hotmail.com","https://orcid.org/0000-0003-4880-537X","https://sciprofiles.com/profile/960308",{"id":1105,"name":1106,"email":1107,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1108},413074,"Christian M Julien","christian.julien@sorbonne-universite.fr","https://sciprofiles.com/profile/686867",{"id":1110,"name":1111,"email":1112,"is_corresponding":6,"orcid_link":1113,"author_mark":266,"sp_link":1114},413075,"Likun Zhu","likzhu@iupui.edu","https://orcid.org/0000-0002-6324-3718","https://sciprofiles.com/profile/70150",{"id":1116,"name":1117,"email":1118,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1119},413076,"Ahmed M. Hashem","ahmedh242@yahoo.com","https://sciprofiles.com/profile/773553",{"manuscript_id":1121,"manuscript_version":7,"hash_key":1122,"id":476,"version":7,"voted":47,"votes":1123,"article_title":1124,"article_abstract":1125,"article_keywords":1126,"top_subject_name":73,"subject_name":1127,"article_type_name":314,"published_at":1128,"download_url":1129,"rank":53,"authors":1130},"202309.0512","36e822e708bbb88c4af8f92289f020bc",7,"Fluoropolymers as Unique and Irreplaceable Materials: Challenges and Future Trends of These Specific Perfluoroalkyl Substances","In contrast to some low molar-mass per- and polyfluoroalkyl substances (PFASs), well-established to be toxic, persistent, bioaccumulative and mobile, fluoropolymers (FPs) are water insoluble, safe, bio-inert, durable niche high performance polymers which fulfil the 13 polymer of low concern (PLC) criteria in their recommended conditions of use. In addition, more recent innovations (e.g., the use of non-fluorinated surfactants in aqueous radical (co)polymerization of fluoroalkenes) from industrial manufacturers of FPs are highlighted. This review also aims at showing how these specialty polymers endowed with outstanding properties are essential (even irreplaceable since hydrocarbon polymer alternatives used in similar conditions fail) for our daily life (electronics, Energy, optics, internet of things, transportation, etc) and constitute a special family a part from other “conventional” C1-C10 PFASs found everywhere on the Earth and Oceans. Furthermore, some information reports the recycling (e.g. the unzipping depolymerization of polytetrafluoroethylene, PTFE, into TFE), end of life of FPs, their risk assessment, circular economy and regulations. Various researches are devoted to Environment involving FPs, though they represent a niche volume (with a yearly production of 330,300 tonnes) compared to all plastics (with 460 million tonnes). Complementary to other reviews on PFASs, which lack of such above data, this review presents both fundamental and applied strategies as evidenced by major FP producers.","end of life; fluoropolymers; per- and polyfluoroalkyl substances (PFAS); polymerization aids; recycling; regulators; surfactants","Polymers and Plastics","2023-09-07 11:18:51","/frontend/manuscript/36e822e708bbb88c4af8f92289f020bc/download_pub",[1131],{"id":1132,"name":1133,"email":1134,"is_corresponding":6,"orcid_link":1135,"author_mark":266,"sp_link":1136},395080,"Bruno Améduri","bruno.ameduri@enscm.fr","https://orcid.org/0000-0003-4217-6664","https://sciprofiles.com/profile/352524",{"category":80,"manuscripts":1138},[1139,1157,1172,1216,1252,1268,1291,1331,1347,1358],{"manuscript_id":1140,"manuscript_version":1141,"hash_key":1142,"id":1143,"version":1141,"voted":47,"votes":1144,"article_title":1145,"article_abstract":1146,"article_keywords":1147,"top_subject_name":80,"subject_name":1148,"article_type_name":140,"published_at":1149,"download_url":1150,"rank":7,"authors":1151},"202108.0146",27,"c9c1e9addb0454e1d3f6463cf97ca2a9",49,125,"A Proof of the Riemann Hypothesis Based on a New Expression of the Completed Zeta Function","The celebrated Riemann Hypothesis (RH) is proved based on a new absolute convergent expression of $\\xi(s)$, which was obtained from the Hadamard product, through paring $\\rho_i$ and $\\bar{\\rho}_i$, and putting all the multiple zeros together in one factor, i.e. $$\\xi(s)=\\xi(0)\\prod_{\\rho}(1-\\frac{s}{\\rho})=\\xi(0)\\prod_{i=1}^{\\infty}\\Big{(}\\frac{\\beta_i^2}{\\alpha_i^2+\\beta_i^2}+\\frac{(s-\\alpha_i)^2}{\\alpha_i^2+\\beta_i^2}\\Big{)}^{d_{i}}$$ where $\\xi(0)=\\frac{1}{2}$, $\\rho_i=\\alpha_i+j\\beta_i$ and $\\bar{\\rho}_i=\\alpha_i-j\\beta_i$ are the complex conjugate zeros of $\\xi(s)$, $0<\\alpha_i<1$ and $\\beta_i\\neq 0$ are real numbers, $d_i\\geq 1$ is the real (unique and unchangeable) multiplicity of $\\rho_i$, $\\beta_i$ are arranged in order of increasing $|\\beta_i|$, i.e., $|\\beta_1|\\leq|\\beta_2|\\leq|\\beta_3|\\leq \\cdots$, $i =1,2,3, \\cdots, \\infty$. Then, according to the functional equation $\\xi(s)=\\xi(1-s)$, we have $$\\prod_{i=1}^{\\infty}\\Big{(}1+\\frac{(s-\\alpha_i)^2}{\\beta_i^2}\\Big{)}^{d_{i}}=\\prod_{i=1}^{\\infty}\\Big{(}1+\\frac{(1-s-\\alpha_i)^2}{\\beta_i^2}\\Big{)}^{d_{i}}$$ which, owing to the uniqueness and unchangeableness of $d_i$ (see Lemma 3 for the proof details), is finally equivalent to $$\\begin{cases}&\\alpha_i=\\frac{1}{2}\\\\ & |\\beta_1|<|\\beta_2|<|\\beta_3|<\\cdots\\\\&i =1,2,3, \\cdots, \\infty \\end{cases}$$ Thus, we conclude that the RH is true.","Riemann Hypothesis (RH); proof; completed zeta function","Algebra and Number Theory","2023-10-30 10:34:15","/frontend/manuscript/c9c1e9addb0454e1d3f6463cf97ca2a9/download_pub",[1152],{"id":1153,"name":1154,"email":1155,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1156},418228,"Weicun Zhang","weicunzhang@ustb.edu.cn","https://sciprofiles.com/profile/779508",{"manuscript_id":1158,"manuscript_version":280,"hash_key":1159,"id":72,"version":280,"voted":47,"votes":861,"article_title":1160,"article_abstract":1161,"article_keywords":1162,"top_subject_name":80,"subject_name":1163,"article_type_name":140,"published_at":1164,"download_url":1165,"rank":280,"authors":1166},"202308.0148","78ddd1f1af2bef40ed40412c82b20f34","GPT-4 Can't Reason","GPT-4 was released in March 2023 to wide acclaim, marking a very substantial improvement across the board over GPT-3.5 (OpenAI's previously best model, which had powered the initial release of ChatGPT). Despite the genuinely impressive improvement, however, there are good reasons to be highly skeptical of GPT-4's ability to reason. This position paper discusses the nature of reasoning; criticizes the current formulation of reasoning problems in the NLP community and the way in which the reasoning performance of LLMs is currently evaluated; introduces a collection of 21 diverse reasoning problems; and performs a detailed qualitative analysis of GPT-4's performance on these problems. Based on the results of this analysis, the paper argues that, despite the occasional flashes of analytical brilliance, GPT-4 at present is utterly incapable of reasoning.","GPT-4; LLM; AI; reasoning; inference","Artificial Intelligence and Machine Learning","2023-08-07 07:13:00","/frontend/manuscript/78ddd1f1af2bef40ed40412c82b20f34/download_pub",[1167],{"id":1168,"name":1169,"email":1170,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1171},379861,"Konstantine Arkoudas","konstantine@alum.mit.edu","https://sciprofiles.com/profile/3073563",{"manuscript_id":1173,"manuscript_version":280,"hash_key":1174,"id":1175,"version":280,"voted":47,"votes":1176,"article_title":1177,"article_abstract":1178,"article_keywords":1179,"top_subject_name":80,"subject_name":1180,"article_type_name":140,"published_at":1181,"download_url":1182,"rank":53,"authors":1183},"202206.0414","e20379d418989a60d86c97ff4779b412",42,18,"Improving the Accuracy of the Deep Energy Method","The deep energy method (DEM), a type of physics-informed neural network, is evolving as an alternative to finite element analysis. This method employs the principle of minimum potential energy to predict deformations under static loading conditions. However, the model’s accuracy is contingent upon choosing the appropriate architecture for the model, which can be challenging due to the high interactions between hyperparameters, large search space, difficulty in identifying objective functions, and non-convex relationships with the objective functions. To improve DEM’s accuracy, we first introduce random Fourier feature (RFF) mapping. RFF mapping helps with the training of the model by reducing bias towards high frequencies. The effects of six hyperparameters are then studied under compression, tension, and bending loads in planar linear elasticity. Based on this study, a systematic automated hyperparameter optimization approach is proposed. Due to the high interaction between hyperparameters and the non-convex nature of the optimization problem, Bayesian optimization algorithms are used. The models trained using optimized hyperparameters and having Fourier feature mapping can accurately predict deflections compared to finite element analysis. Additionally, the deflections obtained for tension and compression load cases are more sensitive to variations in hyperparameters than bending. ","Elasticity; Machine learning; Minimum potential energy; Partial differential equations (PDEs); Physics-informed neural network","Computational Mathematics","2023-04-03 03:29:13","/frontend/manuscript/e20379d418989a60d86c97ff4779b412/download_pub",[1184,1190,1195,1200,1206,1211],{"id":1185,"name":1186,"email":1187,"is_corresponding":47,"orcid_link":1188,"author_mark":148,"sp_link":1189},323735,"Charul Chadha","charulc2@illinois.edu","https://orcid.org/0000-0003-2779-232X","https://sciprofiles.com/profile/1086620",{"id":1191,"name":1192,"email":1193,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1194},323736,"Junyan He","junyanh2@illinois.edu","https://sciprofiles.com/profile/3568033",{"id":1196,"name":1197,"email":1198,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1199},323737,"Diab Abueidda","abueidd2@illinois.edu","https://sciprofiles.com/profile/2304004",{"id":1201,"name":1202,"email":1203,"is_corresponding":47,"orcid_link":1204,"author_mark":148,"sp_link":1205},323738,"Seid Koric","koric@illinois.edu","https://orcid.org/0000-0002-7330-6401","https://sciprofiles.com/profile/1487811",{"id":1207,"name":1208,"email":1209,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1210},323739,"Erman Guleryuz","guleryuz@illinois.edu","https://sciprofiles.com/profile/author/eld3UzRTaWJsNWtVYXJ5Nmx5NU82Y2xEdFltU283ZnBENy9JYlF3OGZGbz0=",{"id":1212,"name":1213,"email":1214,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1215},323740,"Iwona Jasiuk","ijasiuk@illinois.edu","https://sciprofiles.com/profile/3517420",{"manuscript_id":1217,"manuscript_version":270,"hash_key":1218,"id":1219,"version":270,"voted":47,"votes":1176,"article_title":1220,"article_abstract":1221,"article_keywords":1222,"top_subject_name":80,"subject_name":1163,"article_type_name":140,"published_at":1223,"download_url":1224,"rank":53,"authors":1225},"202207.0139","2a77159161e5c7144643f566da891001",43,"Ultra-Sparse Network Advantage in Deep Learning via Cannistraci-Hebb Brain-Inspired Training With Hyperbolic Meta-Deep Community-Layered Epitopology","\u003Cspan>Sparse training (ST) aims to ameliorate deep learning by replacing fully connected artificial neural networks (ANNs) with sparse or ultra-sparse ones, such as brain networks are, therefore it might benefit to borrow brain-inspired learning paradigms from complex network intelligence theory. Here, we launch the ultrasparse advantage challenge, whose goal is to offer evidence on the extent to which ultra-sparse (around 1% connection retained) topologies can achieve any leaning advantage on fully connected. Epitopological learning is a field of network science and complex network intelligence that studies how to implement learning on complex networks by changing the shape of their connectivity structure (epitopological plasticity). One way to implement Epitopological (epi- means new) Learning is via link prediction: predicting the likelihood of nonobserved links to appear in the network. Cannistraci-Hebb learning theory inspired the CH3-L3 network automata rule for link prediction which is effective for general-purpose link prediction. Here, starting from CH3-L3 we propose Epitopological Sparse Meta-deep Learning (ESML) to apply Epitopological Learning to sparse training. In empirical experiments, we find that ESML learns ANNs with ultra-sparse hyperbolic (epi-)topology in which emerges a community layer organization that is meta-deep (meaning that each layer also has an internal depth due to powerlaw node hierarchy). Furthermore, we discover that ESML can in many cases automatically sparse the neurons during training (arriving even to 30% neurons left in hidden layers), this process of node dynamic removal is called percolation. Starting from this network science evidence, we design Cannistraci-Hebb training (CHT), a 4-step training methodology that put ESML at its heart. We conduct experiments on 6 datasets and 3 network structures (MLPs, VGG16, ResNet50) comparing CHT to dynamic sparse training SOTA algorithms and fully connected network. The results indicate that, with a mere 1% of links retained during training, CHT surpasses fully connected networks on VGG16 and ResNet50. This key finding is an evidence for ultra-sparse advantage and signs a milestone in deep learning. CHT acts akin to a gradient-free oracle which adopts CH3-L3 based epitopological learning to guide the placement of new links in the ultra-sparse network topology to facilitate sparse-weight gradient learning, and this in turn reduces the convergence time of ultra-sparse training. Finally, CHT offers first examples of parsimony dynamic sparse training because, in many datasets, it canretain network performance by percolating and significantly reducing the node network size.\u003C/span> ","sparse training; neural networks; link prediction; network automata; Cannistraci-Hebb; epitopological learning","2023-10-30 05:54:50","/frontend/manuscript/2a77159161e5c7144643f566da891001/download_pub",[1226,1231,1236,1241,1246],{"id":1227,"name":1228,"email":1229,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1230},417054,"Yingtao Zhang","zhangyingtao1024@gmail.com","https://sciprofiles.com/profile/2320310",{"id":1232,"name":1233,"email":1234,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1235},417055,"Jialin Zhao","zjl19970607@163.com","https://sciprofiles.com/profile/author/ak9UT0R2NTluQlRDUHBYK2pEN1lGYUo2Vjh6WkJLdkpZd3p4Y05Hc1FDMD0=",{"id":1237,"name":1238,"email":1239,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1240},417056,"Wenjing Wu","wuwj1031@yeah.net","https://sciprofiles.com/profile/author/clhSV1NYVkNkbU5TQU1uNUkrL0ZzU0lwa3pOOGl4NVdDVW9ybnpMbFF3RT0=",{"id":1242,"name":1243,"email":1244,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1245},417057,"Alessandro Muscoloni","alessandro.muscoloni@gmail.com","https://sciprofiles.com/profile/author/UTBSTTRYMThnYnZoSXpiR2J2M1pZekN1SVF5ZVJCNnBVR2pHNW9BTWJTVT0=",{"id":1247,"name":1248,"email":1249,"is_corresponding":6,"orcid_link":1250,"author_mark":266,"sp_link":1251},417058,"Carlo Vittorio Cannistraci","kalokagathos.agon@gmail.com","https://orcid.org/0000-0003-0100-8410","https://sciprofiles.com/profile/1038220",{"manuscript_id":1253,"manuscript_version":132,"hash_key":1254,"id":1255,"version":132,"voted":47,"votes":1064,"article_title":1256,"article_abstract":1257,"article_keywords":1258,"top_subject_name":80,"subject_name":1148,"article_type_name":140,"published_at":1259,"download_url":1260,"rank":53,"authors":1261},"202210.0432","dce371a19408cbaab0fe1886132a0445",47,"Proof of the Collatz Conjecture","The Collatz conjecture (or 3n+1 problem) has been explored for about 86 years. In this article, we prove the Collatz conjecture. We will show that this conjecture holds for all positive integers by applying the Collatz inverse operation to the numbers that satisfy the rules of the Collatz conjecture. Finally, we will prove that there are no positive integers that do not satisfy this conjecture.","Collatz operation; Collatz inverse operation; Collatz numbers","2023-09-06 10:27:26","/frontend/manuscript/dce371a19408cbaab0fe1886132a0445/download_pub",[1262],{"id":1263,"name":1264,"email":1265,"is_corresponding":6,"orcid_link":1266,"author_mark":266,"sp_link":1267},393526,"Bülent Sukuşu","bsukusu.blsu@gmail.com","https://orcid.org/0000-0003-4365-738X","https://sciprofiles.com/profile/2541135",{"manuscript_id":1269,"manuscript_version":280,"hash_key":1270,"id":1271,"version":280,"voted":47,"votes":752,"article_title":1272,"article_abstract":1273,"article_keywords":1274,"top_subject_name":80,"subject_name":1275,"article_type_name":140,"published_at":1276,"download_url":1277,"rank":53,"authors":1278},"202202.0254","dac2b8416a1dace8c92555ab9d76b239",45,"Minimum Uncertainty as Bayesian Network Model Selection Principle","\u003Cspan>In this\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>paper\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>study,\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>we develop a Bayesian Network model selection principle that\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>address\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>addresses\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>the\u003C/span> \u003Cspan>incommensurability of network features obtained from incongruous datasets and overcomes performance\u003C/span> \u003Cspan>irregularities of the Minimum Description Length model selection principle.\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>This is achieved (i) by\u003C/span> \u003Cspan>approaching model evaluation as a classification problem, (ii) by estimating the effect that sampling\u003C/span> \u003Cspan>error has on the satisfiability of conditional independence criterion, as reflected by Mutual Information,\u003C/span> \u003Cspan>and (iii) by utilizing this error estimate to penalize uncertainty in the Minimum Uncertainty (MU) model\u003C/span> \u003Cspan>selection principle. We validate our findings numerically and demonstrate the performance advantages\u003C/span> \u003Cspan>of the MU criterion. Finally, we illustrate the advantages of the new model evaluation framework on a\u003C/span> \u003Cspan>tRNA structural biology example.\u003C/span>","Bayesian Networks; probabilistic networks; conditional independence; model selection criteria; mutual information; sampling error; statistical uncertainty; MDL; BIC; AIC; BD; tRNA","Applied Mathematics","2023-06-07 13:20:18","/frontend/manuscript/dac2b8416a1dace8c92555ab9d76b239/download_pub",[1279,1285],{"id":1280,"name":1281,"email":1282,"is_corresponding":6,"orcid_link":1283,"author_mark":266,"sp_link":1284},351549,"Grigoriy Gogoshin","ggogoshin@coh.org","https://orcid.org/0000-0003-0675-1799","https://sciprofiles.com/profile/2066734",{"id":1286,"name":1287,"email":1288,"is_corresponding":47,"orcid_link":1289,"author_mark":148,"sp_link":1290},351550,"Andrei Rodin","arodin@coh.org","https://orcid.org/0000-0002-2570-0332","https://sciprofiles.com/profile/357717",{"manuscript_id":1292,"manuscript_version":280,"hash_key":1293,"id":1294,"version":280,"voted":47,"votes":1295,"article_title":1296,"article_abstract":1297,"article_keywords":1298,"top_subject_name":80,"subject_name":1299,"article_type_name":314,"published_at":1300,"download_url":1301,"rank":53,"authors":1302},"202202.0123","aec6ee37924d4eeaa220f74e2c729a33",48,5,"Practical Autonomous Driving: A Survey of Challenges and Opportunities","Autonomous Driving (AD) has become a prominent research area in the field of Artificial Intelligence (AI) and Machine Learning (ML) in recent years. This opens the door wider for self-driving cars to surpass conventional vehicles in the current market share. Despite its apparent simplicity, AD is composed of complex and heterogeneous systems, which are in need of a high level of coordination and alignment to ensure both full automation and safety. Therefore, numerous research studies have been conducted over the last few years to facilitate such coordination and accelerate the capacity of these types of vehicles to be self-managed in complex situations. The paper summarises these approaches that led to building what is known nowadays as the autonomous driving pipeline. Moreover, although skepticism exists regarding the practicality of AD as a viable alternative to traditional vehicles, extensive research suggests the multiple benefits of relying on them for mobility. While challenges remain in implementing AD in the real world, including regulation and technical issues, substantial progress in recent years indicates a growing acceptance of AD in the near future. This paper further explores the advantages and opportunities of the conducted such systems in facilitating the practicality of Autonomous Driving.","cnn; ann; robotics; machine learning; ann; artificial intelligence","Robotics","2023-10-10 12:28:06","/frontend/manuscript/aec6ee37924d4eeaa220f74e2c729a33/download_pub",[1303,1308,1313,1319,1325],{"id":1304,"name":1305,"email":1306,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1307},407818,"Shuvodeep De","des1@ornl.gov","https://sciprofiles.com/profile/981780",{"id":1309,"name":1310,"email":1311,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1312},407819,"Debanjan Saha","debanjan.aiml@gmail.com","https://sciprofiles.com/profile/author/Z1ovWEpkWHMwTFRnUlcrRmFwMklwZVl4RFdWWVVsdzc3Szk3VVB2NHZoST0=",{"id":1314,"name":1315,"email":1316,"is_corresponding":47,"orcid_link":1317,"author_mark":148,"sp_link":1318},407823,"Karam Sallam","karam.sallam@canberra.edu.au","https://orcid.org/0000-0001-5767-2818","https://sciprofiles.com/profile/2167356",{"id":1320,"name":1321,"email":1322,"is_corresponding":47,"orcid_link":1323,"author_mark":148,"sp_link":1324},407824,"Ali Mohamed","aliwagdy@gmail.com","https://orcid.org/0000-0002-5895-2632","https://sciprofiles.com/profile/161677",{"id":1326,"name":1327,"email":1328,"is_corresponding":47,"orcid_link":1329,"author_mark":148,"sp_link":1330},407825,"Ibrahim Radwan","ibrahim.radwan@canberra.edu.au","https://orcid.org/0000-0002-8170-5058","https://sciprofiles.com/profile/1676357",{"manuscript_id":1332,"manuscript_version":1064,"hash_key":1333,"id":1334,"version":1064,"voted":47,"votes":132,"article_title":1335,"article_abstract":1336,"article_keywords":1337,"top_subject_name":80,"subject_name":1275,"article_type_name":140,"published_at":1338,"download_url":1339,"rank":53,"authors":1340},"202210.0091","a7746467c830ae59f484262f9c9ed000",44,"Dual Variational Formulations for a Large Class of Non-Convex Models in the Calculus of Variations","This article develops dual variational formulations for a large class of models in variational optimization. The results are established through basic tools of functional analysis, convex analysis and duality theory. The main duality principle is developed as an application to a Ginzburg-Landau type system in superconductivity in the absence of a magnetic field. In the first sections, we develop new general dual convex variational formulations, more specifically, dual formulations with a large region of convexity around the critical points which are suitable for the non-convex optimization for a large class of models in physics and engineering. Finally, in the last section we present some numerical results concerning the generalized method of lines applied to a Ginzburg-Landau type equation.","Duality principles; Generalized method of lines; Ginzburg-Landau type equations","2023-01-29 09:58:00","/frontend/manuscript/a7746467c830ae59f484262f9c9ed000/download_pub",[1341],{"id":1342,"name":1343,"email":1344,"is_corresponding":6,"orcid_link":1345,"author_mark":266,"sp_link":1346},313527,"Fabio Botelho","fabio.botelho@ufsc.br","https://orcid.org/0000-0002-3890-8263","https://sciprofiles.com/profile/2321302",{"manuscript_id":1348,"manuscript_version":1255,"hash_key":1349,"id":1350,"version":1255,"voted":47,"votes":132,"article_title":1351,"article_abstract":1352,"article_keywords":1353,"top_subject_name":80,"subject_name":1275,"article_type_name":140,"published_at":53,"download_url":1354,"rank":53,"authors":1355},"202302.0051","3de88676889cc018431eaaeca427e730",46,"Duality Principles and Numerical Procedures for a Large Class of Non-convex Models in the Calculus of Variations","This article develops duality principles and numerical results for a large class of non-convex variational models. The main results are based on fundamental tools of convex analysis, duality theory and calculus of variations. More specifically the approach is established for a class of non-convex functionals similar as those found in some models in phase transition. Finally, in some sections we present concerning numerical examples and the respective softwares.","duality theory; non-convex analysis; numerical method for a non-smooth model","/frontend/manuscript/3de88676889cc018431eaaeca427e730/download_pub",[1356],{"id":1357,"name":1343,"email":1344,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1346},446019,{"manuscript_id":1359,"manuscript_version":1034,"hash_key":1360,"id":65,"version":1034,"voted":47,"votes":132,"article_title":1361,"article_abstract":1362,"article_keywords":1363,"top_subject_name":80,"subject_name":1148,"article_type_name":140,"published_at":1364,"download_url":1365,"rank":53,"authors":1366},"202110.0087","f6bd353512087e000189d9259370d3d9","On the Additive and Subtractive Representation of Even Numbers from Primes","\u003Cspan>We demonstrate a new quantitative method to the sieve of Eratosthenes, which is an alternative to the sieve of Legendre. In this method, every element of a given set is sifted out once only, and therefore, this method is free of the Mobius function and of the parity barrier. Using this method, we prove that every su\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>ciently large even number is the sum of two primes, and that every even number is the di\u003C/span>\u003Cspan>ff\u003C/span>\u003Cspan>erence of two primes in infinitely many ways.\u003C/span>","sieve of eratosthenes; goldbach conjecture; polignac conjecture; twin prime conjecture","2023-08-10 05:23:00","/frontend/manuscript/f6bd353512087e000189d9259370d3d9/download_pub",[1367,1373],{"id":1368,"name":1369,"email":1370,"is_corresponding":6,"orcid_link":1371,"author_mark":266,"sp_link":1372},382426,"Ali Shehu","a.shehu@qmul.ac.uk","https://orcid.org/0000-0002-9913-4038","https://sciprofiles.com/profile/84205",{"id":1374,"name":1375,"email":1376,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1377},382427,"Jetmira Uka","jetmira.uka@brunel.ac.uk","https://sciprofiles.com/profile/author/UWpOVldzak1OYXlpMFo4VFZOWmNFdWx5OXI2eE5XYllRbDF3dHdPZlpZMD0=",{"category":87,"manuscripts":1379},[1380,1402,1455,1522,1571,1604,1620,1636,1661,1705],{"manuscript_id":1381,"manuscript_version":7,"hash_key":1382,"id":1383,"version":7,"voted":47,"votes":817,"article_title":1384,"article_abstract":1385,"article_keywords":1386,"top_subject_name":87,"subject_name":1387,"article_type_name":140,"published_at":1388,"download_url":1389,"rank":7,"authors":1390},"202306.1106","dd04d48d14c81c5e1bcc7698e2e70cb7",29,"An Explainable Vision Transformer Model Based White Blood Cells Classification and Localization","Blood cell analysis is a crucial diagnostic process in medical practice. In particular, detecting white blood cells (WBCs) is essential for diagnosing of many diseases. The manual screening of blood films is a time-consuming and subjective process, which can lead to inconsistencies and errors. Therefore, automated detection of blood cells can improve the accuracy and efficiency of the screening process. In this study, an explainable Vision Transformer (ViT) model was proposed for the automatic detection of WBCs from blood films. The proposed model utilizes the self-attention mechanism to extract relevant features from the input images and leverages transfer learning by incorporating pre-trained model weights to improve its performance. The proposed model achieved a classification accuracy of 99.40% for five distinct types of WBCs and exhibited potential in reducing the time required for manual screening of blood films by pathologists. Upon examination of the misclassified test samples, it was observed that incorrect predictions were correlated with the presence or absence of granules in the cell samples. To validate this observation, the dataset was divided into two classes, namely Granulocytes and Agranulocytes, and a secondary training process was conducted. The resulting ViT model trained for binary classification achieved an accuracy of 99.70%, recall of 99.54%, precision of 99.32%, and F-1 score of 99.43% during the test phase. To ensure the reliability of the ViT model's multi-class classification of WBCs, the pixel areas that the model focuses on in its predictions are visualized through the Score-CAM algorithm.","Vision Transformers; white blood cells; explainable AI models; deep learning; Score-CAM","Other","2023-06-15 08:42:51","/frontend/manuscript/dd04d48d14c81c5e1bcc7698e2e70cb7/download_pub",[1391,1397],{"id":1392,"name":1393,"email":1394,"is_corresponding":47,"orcid_link":1395,"author_mark":148,"sp_link":1396},355422,"Oguzhan Katar","okatar@firat.edu.tr","https://orcid.org/0000-0002-5628-3543","https://sciprofiles.com/profile/2637316",{"id":1398,"name":1399,"email":1400,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1401},355423,"Ozal Yildirim","ozalyildirim@firat.edu.tr","https://sciprofiles.com/profile/1865361",{"manuscript_id":1403,"manuscript_version":7,"hash_key":1404,"id":1405,"version":7,"voted":47,"votes":1406,"article_title":1407,"article_abstract":1408,"article_keywords":1409,"top_subject_name":87,"subject_name":1410,"article_type_name":314,"published_at":1411,"download_url":1412,"rank":280,"authors":1413},"202303.0072","fa1c4526d5a290a8e856f5cb8b0d8505",23,33,"Glycosylation Shapes the Efficacy and Safety of Diverse Protein, Gene and Cell Therapies","Over recent decades, therapeutic proteins have had widespread success in treating a myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical quality attribute that significantly influences the physical properties, safety profile and biological activity of therapeutic proteins. Optimizing protein glycosylation, therefore, offers an important avenue to developing more efficacious therapies. In this review, we discuss specific examples of how variations in glycan structure and glycoengineering impacts the stability, safety, and clinical efficacy of protein-based drugs that are already in the market as well as those that are still in preclinical development. We also highlight the impact of glycosylation on next generation biologics such as T cell-based cancer therapy and gene therapy. ","glycosylation, glycoengineering, biologic, therapeutic protein, gene therapy, cell-based therapy, monoclonal antibody","Bioengineering","2023-03-03 10:43:51","/frontend/manuscript/fa1c4526d5a290a8e856f5cb8b0d8505/download_pub",[1414,1419,1424,1429,1434,1439,1444,1450],{"id":1415,"name":1416,"email":1417,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1418},319462,"Frances Rocamora","frocamora@health.ucsd.edu","https://sciprofiles.com/profile/author/TFdSdUQvR0ljamk1KzQzK2d4NzFsSmdkQUxEY09ocmlYT05DQkY5Tys4dz0=",{"id":1420,"name":1421,"email":1422,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1423},319463,"Angelo G Peralta","aperaltaprieto@health.ucsd.edu","https://sciprofiles.com/profile/author/cTlGQ3NRa05nMVd4cGszeVJ4QVdMMFdwZUFWeUJuNzFXQnZGSHBlcFo5OD0=",{"id":1425,"name":1426,"email":1427,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1428},319464,"Seunghyeon Shin","s9shin@health.ucsd.edu","https://sciprofiles.com/profile/author/cDVDYXA0WTAweHdPVmVGNFJxdjJXZWJZVnp6RGxUdmhBNDNLdG94dVQ2bz0=",{"id":1430,"name":1431,"email":1432,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1433},319465,"James Sorrentino","jtsorren@eng.ucsd","https://sciprofiles.com/profile/author/djA3VUMyTnRUektMUEVVSFQwTGpCOTc1YUtDVExPQUNHc1JGWjlodzlmND0=",{"id":1435,"name":1436,"email":1437,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1438},319466,"Mina Wu","ymwu@ucsd.edu","https://sciprofiles.com/profile/author/Z3JGZlJRMnRMLzBOZk5PYmd6WmEwdz09",{"id":1440,"name":1441,"email":1442,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1443},319467,"Eric A Toth","etoth@som.umaryland.edu","https://sciprofiles.com/profile/151320",{"id":1445,"name":1446,"email":1447,"is_corresponding":47,"orcid_link":1448,"author_mark":148,"sp_link":1449},319468,"Thomas R Fuerst","tfuerst@umd.edu","https://orcid.org/0000-0002-9766-9995","https://sciprofiles.com/profile/979962",{"id":1451,"name":1452,"email":1453,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1454},319469,"Nathan E Lewis","n4lewis@ucsd.edu","https://sciprofiles.com/profile/861586",{"manuscript_id":1456,"manuscript_version":280,"hash_key":1457,"id":1458,"version":280,"voted":47,"votes":1459,"article_title":1460,"article_abstract":1461,"article_keywords":1462,"top_subject_name":87,"subject_name":1463,"article_type_name":314,"published_at":1464,"download_url":1465,"rank":53,"authors":1466},"202306.0228","e0788e3092392af3f6ec0cadc4b9f428",30,32,"A Comprehensive Review of EV Lithium-Ion Battery Degradation","Lithium-ion batteries with improved energy densities have made understanding the Solid Electrolyte Interphase (SEI) generation mechanisms that cause mechanical, thermal, and chemical failures more complicated. SEI processes reduce battery capacity and power. Thus, a review of this area's understanding is important. It is essential to know how batteries degrade in EVs to estimate battery lifespan as it goes, predict, and minimize losses, and determine the ideal time for a replacement. Lithium-ion batteries used in EVs mainly suffer two types of degradation: calendar degradation and cycling degradation. Despite the existence of several existing works in the literature, several aspects of battery degradation remain unclear or have not been analyzed in detail. This work presents a systematic review of existing works in the literature. The results of the present investigation provide insight into the complex relationships among various factors affecting battery degradation mechanisms. Specifically, this systematic review examined the effects of time, side reactions, temperature fluctuations, high charge/discharge rates, depth of discharge, mechanical stress, thermal stress, and the voltage relationship on battery performance and longevity. The results revealed that these factors interact in complex ways to influence the degradation mechanisms of batteries. For example, high charge currents and deep discharges were found to accelerate degradation, while low temperatures and moderate discharge depths were shown to be beneficial for battery longevity. Additionally, the results showed that the relationship between cell voltage and State-of-Charge (SOC) plays a critical role in determining the rate of degradation. Overall, these findings have important implications for the design and operation of battery systems, as they highlight the need to carefully manage a range of factors to maximize battery performance and longevity. The result is an analysis of the main articles published in this field in recent years. This work aims to present new knowledge about fault detection, diagnosis, and management of lithium-ion batteries based on battery degradation concepts. The new knowledge is presented and discussed in a structured and comprehensive way.","Prognostics; Ageing; Lithium-Ion Batteries; EV Batteries; Degradation; Electric vehicles; Failure; Solid Electrolyte Interphase; Lifespan Estimation; Battery Performance; Diagnostics; Lifetime Prediction","Electrical and Electronic Engineering","2023-11-21 13:16:44","/frontend/manuscript/e0788e3092392af3f6ec0cadc4b9f428/download_pub",[1467,1472,1477,1483,1488,1494,1500,1506,1511,1517],{"id":1468,"name":1469,"email":1470,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1471},426595,"Carlos Antônio Rufino Júnior","carlos.rufino@carissma.eu","https://sciprofiles.com/profile/3424500",{"id":1473,"name":1474,"email":1475,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1476},426596,"Eleonora Riva Sanseverino","eleonora.rivasanseverino@community.unipa.it","https://sciprofiles.com/profile/116497",{"id":1478,"name":1479,"email":1480,"is_corresponding":47,"orcid_link":1481,"author_mark":148,"sp_link":1482},426597,"Pierluigi Gallo","pierluigi.gallo@unipa.it","https://orcid.org/0000-0002-6333-5997","https://sciprofiles.com/profile/728271",{"id":1484,"name":1485,"email":1486,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1487},426598,"Murilo Machado Amaral","m.machadoamaral@yahoo.com.br","https://sciprofiles.com/profile/author/ZC80c1BnNnlMZ09Pams1QklzSDI2MXhwSGpoQm1hVHl0Yi9objNSSzJtRT0=",{"id":1489,"name":1490,"email":1491,"is_corresponding":47,"orcid_link":1492,"author_mark":148,"sp_link":1493},426599,"Daniel Koch","daniel.koch@carissma.eu","https://orcid.org/0000-0003-2581-2825","https://sciprofiles.com/profile/1639075",{"id":1495,"name":1496,"email":1497,"is_corresponding":47,"orcid_link":1498,"author_mark":148,"sp_link":1499},426600,"Yash Kotak","yash.kotak@carissma.eu","https://orcid.org/0000-0003-2730-4904","https://sciprofiles.com/profile/1336673",{"id":1501,"name":1502,"email":1503,"is_corresponding":47,"orcid_link":1504,"author_mark":148,"sp_link":1505},426601,"Sergej Diel","sergej.diel@thi.de","https://orcid.org/0000-0003-3443-0765","https://sciprofiles.com/profile/3272925",{"id":1507,"name":1508,"email":1509,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1510},426602,"Walter Gero","gero.walter@carissma.eu","https://sciprofiles.com/profile/3265378",{"id":1512,"name":1513,"email":1514,"is_corresponding":47,"orcid_link":1515,"author_mark":148,"sp_link":1516},426603,"Hans-Georg Schweiger","hans-georg.schweiger@thi.de","https://orcid.org/0000-0003-0184-1322","https://sciprofiles.com/profile/655229",{"id":1518,"name":1519,"email":1520,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1521},426604,"Hudson Zanin","hzanin@unicamp.br","https://sciprofiles.com/profile/2982290",{"manuscript_id":1523,"manuscript_version":280,"hash_key":1524,"id":1525,"version":280,"voted":47,"votes":1525,"article_title":1526,"article_abstract":1527,"article_keywords":1528,"top_subject_name":87,"subject_name":1529,"article_type_name":140,"published_at":1530,"download_url":1531,"rank":53,"authors":1532},"202209.0386","59cd91dda390ce2a99867c6a11b6dae6",28,"Conceptualising Micromobility: The Multi-Dimensional and Socio-Technical Perspective","Micromobility has gained attention from policymakers, industry stakeholders, and academia; however, a comprehensive conceptualization of micromobility is still missing. Existing definitions are largely vehicle-centric: either listing modes or detailing vehicle characteristics. This paper addresses this gap by developing a ‘beyond vehicles’, multi-dimensional conceptualization of micromobility, accompanied by a novel socio-technical definition. Through a review of related concepts, combined with an analysis of the use and definitions of the term micromobility in publications, this study establishes a new conceptualization of micromobility. It incorporates human, social, and cultural dimensions, considers environmental, economic, infrastructure, vehicle technology, regulatory and policy aspects, and considerations for public health. Our definition of micromobility encompasses a wide range of mobility options typically used for shorter trips and manoeuvrable by an individual without motor assistance, at least for short distances. These modes are characterized by their ‘micro’ attributes, including low energy demand, environmental impact, and road space use relative to automobility. The conceptualization incorporates a range of micromobility modes, including fully human-powered (including walking), partially motor-assisted, and fully powered options. These modes typically operate at speeds not exceeding 25 to 32 kilometres per hour (or 45 km/h for faster options), weigh (typically substantially) below 350 kilograms and often yield significant (public) health benefits. Trip length is generally less than 15 kilometres, and daily distances under 80 kilometres. Importantly, our definition includes the practices, policies, cultures, and infrastructures that emerge around the use of micromobility options and shape their uptake. This proposed conceptualization significantly broadens the prevailing vehicle-focus in micromobility debates towards a socio-technical perspective. Embracing a widely accepted conceptualisation of micromobility would offer several advantages, including robust design standards, legislation, and evaluation metrics and methods. Additionally, this paper highlights the pivotal role micromobilities can play in transcending the limitations of automobility, towards more sustainable and equitable mobility futures.","micromobility; sustainable transport; electric vehicles; active travel; LEV; so-cio-technical analysis","Transportation Science and Technology","2023-06-28 02:20:07","/frontend/manuscript/59cd91dda390ce2a99867c6a11b6dae6/download_pub",[1533,1538,1543,1549,1554,1560,1565],{"id":1534,"name":1535,"email":1536,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1537},290282,"Frauke Behrendt","f.behrendt@tue.nl","https://sciprofiles.com/profile/546170",{"id":1539,"name":1540,"email":1541,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1542},290283,"Eva Heinen","eva.heinen@tu-dortmund.de","https://sciprofiles.com/profile/author/THE3VXpZOEExRTdwT2w1T0ZOSHJBSmpNYWZnWk5PdC9NVG45TENvZFlnVT0=",{"id":1544,"name":1545,"email":1546,"is_corresponding":47,"orcid_link":1547,"author_mark":148,"sp_link":1548},290284,"Christian Brand","christian.brand@ouce.ox.ac.uk","https://orcid.org/0000-0002-1535-5328","https://sciprofiles.com/profile/1253452",{"id":1550,"name":1551,"email":1552,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1553},290285,"Sally Cairns","sallycairns@outlook.com","https://sciprofiles.com/profile/author/MXNyYW10Y1VUNC83UU1lL3A1V2Ira29aemdLckQyT3FJcnhMRnZSS0h6UT0=",{"id":1555,"name":1556,"email":1557,"is_corresponding":47,"orcid_link":1558,"author_mark":148,"sp_link":1559},290286,"Jillian Anable","j.l.anable@leeds.ac.uk","https://orcid.org/0000-0002-4259-1641","https://sciprofiles.com/profile/3144183",{"id":1561,"name":1562,"email":1563,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1564},290287,"Labib Azzouz","labib.azzouz@ouce.ox.ac.uk","https://sciprofiles.com/profile/3682862",{"id":1566,"name":1567,"email":1568,"is_corresponding":47,"orcid_link":1569,"author_mark":148,"sp_link":1570},360560,"Clara Glachant","c.g.glachant@tue.nl","https://orcid.org/0009-0007-9251-7443","https://sciprofiles.com/profile/3440943",{"manuscript_id":1572,"manuscript_version":7,"hash_key":1573,"id":1574,"version":7,"voted":47,"votes":1141,"article_title":1575,"article_abstract":1576,"article_keywords":1577,"top_subject_name":87,"subject_name":1578,"article_type_name":140,"published_at":1579,"download_url":1580,"rank":53,"authors":1581},"202305.1378","ad148ad07d5256aa15c6a1b0fde46bfa",24,"Identifying Barriers to Effective BIM Adoption in the Re-Engineering of Construction Business Practices in Developing Countries","Building Information Modelling (BIM) has been more popular in the construction industry as a consequence of the many advantages it offers, such as increased productivity, improved project outcomes, and reduced expenses. However, there are many obstacles that must be overcome before BIM can be widely used. This research uses a poll of construction industry experts to investigate the challenges associated with using BIM in projects. Cost of implementation, inadequate standards and procedures, and a lack of knowledge with BIM were some of the hurdles that were measured in the study. Statistical techniques were used to examine the data, and the findings indicate that the high cost of implementation and the absence of sufficient standards and procedures are the two main obstacles to the widespread adoption of BIM. Problems with supply chain management and a lack of experience with BIM are also mentioned as obstacles. The report also suggests solutions, such as a more focused teaching effort on BIM-related issues and the creation of a specialised BIM curriculum. Professionals in the construction industry may utilise the study’s results to their advantage by expanding their knowledge of the obstacles standing in the way of widespread adoption of BIM.","Building Information Modeling; BIM Adoption; Construction Business; Developing Countries; Re-Engineering.","Architecture, Building and Construction","2023-05-19 04:39:32","/frontend/manuscript/ad148ad07d5256aa15c6a1b0fde46bfa/download_pub",[1582,1588,1593,1599],{"id":1583,"name":1584,"email":1585,"is_corresponding":47,"orcid_link":1586,"author_mark":148,"sp_link":1587},341785,"Firoz Alam","f.alam@seu.edu.sa","https://orcid.org/0000-0003-1621-1729","https://sciprofiles.com/profile/2702843",{"id":1589,"name":1590,"email":1591,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1592},341786,"Javed Ali","j.ali@seu.edu.sa","https://sciprofiles.com/profile/1893632",{"id":1594,"name":1595,"email":1596,"is_corresponding":47,"orcid_link":1597,"author_mark":148,"sp_link":1598},341787,"Syed Madni","madni4all@yahoo.com","https://orcid.org/0000-0002-3816-1382","https://sciprofiles.com/profile/231750",{"id":1600,"name":1601,"email":1602,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1603},341788,"Hafiz Ali Husnain","aleehusnain007@gmail.com","https://sciprofiles.com/profile/author/U0p2SXp1VmZ1WWcrOFA5SHBRdFIxbTdYelNURHdXOWRkZEZwR1g5dDRIZz0=",{"manuscript_id":1605,"manuscript_version":7,"hash_key":1606,"id":20,"version":7,"voted":47,"votes":1607,"article_title":1608,"article_abstract":1609,"article_keywords":1610,"top_subject_name":87,"subject_name":1611,"article_type_name":140,"published_at":1612,"download_url":1613,"rank":53,"authors":1614},"202305.1758","f2395c494f3e0f486356cdd2dd03992a",25,"Digital Twin Certified: Employing Virtual Testing of Digital Twins in Manufacturing to Ensure Quality Products","Quality products are a main focus for manufacturers. Product users only determine a product is a quality product if it performs in operation to the user’s perceived standard. Product manufactures need to take a product lifecycle quality (PLQ) perspective of quality and not simply focus on manufacturing quality control, which is more accurately specification control. Manufacturing is the key phase where products take their physical form. There are increasing costs and decreasing risk of different physical quality strategies. The information provided using digital twins and virtual testing promises to be both low risk and cost and has the potential to predict what the customer will experience in operation by testing products passively with data and actively with simulation to destruction. Digital Twin Certified (DTC) is proposed as the methodology for accomplishing this. DTC will be especially important for the adoption of additive manufacturing.","Digital Twin; DT; Product Lifecycle Quality; PLQ; Digital Twin Certified; DTC","Industrial and Manufacturing Engineering","2023-05-25 07:46:34","/frontend/manuscript/f2395c494f3e0f486356cdd2dd03992a/download_pub",[1615],{"id":1616,"name":1617,"email":1618,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1619},344025,"Michael Grieves","michael.grieves@ucf.edu","https://sciprofiles.com/profile/2962934",{"manuscript_id":1621,"manuscript_version":270,"hash_key":1622,"id":1141,"version":270,"voted":47,"votes":20,"article_title":1623,"article_abstract":1624,"article_keywords":1625,"top_subject_name":87,"subject_name":1626,"article_type_name":140,"published_at":1627,"download_url":1628,"rank":53,"authors":1629},"202108.0125","e01fcc004fcd7835237a168e71105cb2","Self-Organized Criticality of Traffic Flow: Implications for Congestion Management Technologies","\u003Cspan>Self-organized criticality (SOC) is a celebrated paradigm from the 90’s for understanding dynamical systems naturally \u003C/span>\u003Cspan>driven to its critical point, where the power-law dynamics taking place make predictions practically impossible, such \u003C/span>\u003Cspan>as in stock prices, earthquakes, pandemics and many other problems in science related to phase transitions. Shortly \u003C/span>\u003Cspan>thereafter, it was realized that tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c flow might be in the SOC category, implying that conventional tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c management \u003C/span>\u003Cspan>strategies seeking to maximize the local flows can become detrimental. This paper shows that the Kinematic Wave \u003C/span>\u003Cspan>model with triangular fundamental diagram, and many other related tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c models, indeed exhibit SOC, thanks in part\u003C/span> \u003Cspan>to the fractal nature of tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c exposed here on the one hand, and our need to get to our destinations as soon as possible, \u003C/span>\u003Cspan>on the other hand. Important implications for congestion management of tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c near the critical region are discussed, \u003C/span>\u003Cspan>such as:\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>(i) Jam sizes obey a power-law distribution with exponent 1\u003C/span>\u003Cspan>/\u003C/span>\u003Cspan>2, implying that both its mean and variance \u003C/span>\u003Cspan>become ill-defined and therefore impossible to estimate. (ii) Tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c in the critical region is chaotic in the sense that \u003C/span>\u003Cspan>predictions becomes extremely sensitive to initial conditions. (iii) However, aggregate measures of performance such \u003C/span>\u003Cspan>as delays and average speeds are not heavy tailed, and can be characterized exactly by di\u003C/span>\u003Cspan>ff\u003C/span>\u003Cspan>erent scalings of the Airy \u003C/span>\u003Cspan>distribution, (iv) Tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c state time-space “heat maps” are self-a\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>ne fractals where the basic unit is a triangle, in the \u003C/span>\u003Cspan>shape of the fundamental diagram, containing 3 tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c states: voids, capacity and jams. This fractal nature of tra\u003C/span>\u003Cspan>ffi\u003C/span>\u003Cspan>c\u003C/span> \u003Cspan>flow calls for analysis methods currently not used in our field.\u003C/span>","traffic flow; kinematic wave model; self-organized criticality; fractals; complexity; catastrophe theory ; non-equilibrium critical phenomena","Civil Engineering","2023-02-03 13:50:11","/frontend/manuscript/e01fcc004fcd7835237a168e71105cb2/download_pub",[1630],{"id":1631,"name":1632,"email":1633,"is_corresponding":6,"orcid_link":1634,"author_mark":266,"sp_link":1635},314434,"Jorge Laval","jlaval3@ce.gatech.edu","https://orcid.org/0000-0002-0986-4046","https://sciprofiles.com/profile/1691896",{"manuscript_id":1637,"manuscript_version":270,"hash_key":1638,"id":985,"version":270,"voted":47,"votes":1295,"article_title":1639,"article_abstract":1640,"article_keywords":1641,"top_subject_name":87,"subject_name":1410,"article_type_name":140,"published_at":1642,"download_url":1643,"rank":53,"authors":1644},"202304.0575","0b3394138661dc3e427bc5cd788c92bc","Imagined Speech Classification Using EEG and Deep Learning","In this paper, we propose an imagined speech-based brain wave pattern recognition using deep learning. Multiple features were extracted concurrently from eight-channel Electroencephalography (EEG) signals. To obtain classifiable EEG data with fewer number of sensors, we placed the EEG sensors on carefully selected spots on the scalp. To decrease the dimensions and complexity of the EEG dataset and to avoid overfitting during the deep learning algorithm, we utilized the wavelet scattering transformation. A low-cost 8-channel EEG headset was used with MATLAB 2023a to acquire the EEG data. The Long-Short Term Memory Recurrent Neural Network (LSTM-RNN) was used to decode the identified EEG signals into four audio commands: Up, Down, Left, and Right. Wavelet scattering transformation was applied to extract the most stable features by passing the EEG dataset through a series of filtration processes. Filtration has been implemented for each individual command in the EEG datasets. The proposed imagined speech-based brain wave pattern recognition approach achieved a 92.50% overall classification accuracy. This accuracy is promising for designing a trustworthy imagined speech-based Brain-Computer Interface (BCI) future real-time systems. For better evaluation of the classification performance, other metrics were considered, and we obtained 92.74%, 92.50% and 92.62% for precision, recall, and F1-score, respectively.","Inner Speech; Imagined Speech; EEG Decoding; Brain-Computer Interface; BCI; LSTM; Wavelet Scattering Transformation; WST.","2023-05-15 05:43:54","/frontend/manuscript/0b3394138661dc3e427bc5cd788c92bc/download_pub",[1645,1650,1655],{"id":1646,"name":1647,"email":1648,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1649},339225,"Mokhles M. Abdulghani","mokhles.m.abdulghani@students.jsums.edu","https://sciprofiles.com/profile/1040131",{"id":1651,"name":1652,"email":1653,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1654},339226,"Wilbur L. Walters","wilbur.l.walters@jsums.edu","https://sciprofiles.com/profile/author/eEYrcnRmdlh1bEJBbjVCUjFlOFpLS3FyS2RWbXBkd09WSy94OTlubE4rUT0=",{"id":1656,"name":1657,"email":1658,"is_corresponding":6,"orcid_link":1659,"author_mark":266,"sp_link":1660},339227,"And Khalid H. Abed","khalid.h.abed@jsums.edu","https://orcid.org/0000-0001-6928-4564","https://sciprofiles.com/profile/2901253",{"manuscript_id":1662,"manuscript_version":7,"hash_key":1663,"id":1607,"version":7,"voted":47,"votes":270,"article_title":1664,"article_abstract":1665,"article_keywords":1666,"top_subject_name":87,"subject_name":1463,"article_type_name":140,"published_at":1667,"download_url":1668,"rank":53,"authors":1669},"202304.0124","61c1700fd060bf273e7f5da7eb091f2f","DC-YOLOv8: Small Size Object Detection Algorithm Based on Camera Sensor","Traditional camera sensors rely on human eyes for observation. However, the human eye 1\r\nis prone to fatigue when observing targets of different sizes for a long time in complex scenes, and 2\r\nhuman cognition is limited, which often leads to judgment errors and greatly reduces the efficiency. 3\r\nTarget recognition technology is an important technology to judge the target category in camera 4\r\nsensor. In order to solve this problem, a small size target detection algorithm for special scenarios was 5\r\nproposed by this paper. Its advantage is that this algorithm not only has higher precision for small 6\r\nsize target detection, but also can ensure that the detection accuracy of each size is not lower than the 7\r\nexisting algorithm. In this paper, a new down-sampling method was proposed, which could better 8\r\npreserve the context feature information. The feature fusion network was improved to effectively 9\r\ncombine shallow information and deep information. A new network structure was proposed to 10\r\neffectively improve the detection accuracy of the model. In terms of accuracy, it is better than: YOLOX, 11\r\nYOLOXR, YOLOv3, scaled YOLOv5, YOLOv7-Tiny and YOLOv8.Three authoritative public data sets 12\r\nwere used in this experiment: a) On Visdron data sets (small size targets), DC-YOLOv8 is 2.5% more 13\r\naccurate than YOLOv8. b) On Tinyperson data sets (minimal size targets), DC-YOLOv8 is 1% more 14\r\naccurate than YOLOv8. c) On PASCAL VOC2007 data sets (Normal size target), DC-YOLOv8 is 0.5% 15\r\nmore accurate than YOLOv8.","YOLOv8; small size targets; target detection; feature fusion","2023-04-07 11:35:23","/frontend/manuscript/61c1700fd060bf273e7f5da7eb091f2f/download_pub",[1670,1675,1680,1685,1690,1695,1700],{"id":1671,"name":1672,"email":1673,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1674},324759,"Haitong Lou","10431210427@stu.qlu.edu.cn","https://sciprofiles.com/profile/author/NVNSZUFiU3M3MW5pbnlpMHBZc2F1ZFBmbW9zeTZWVi9ZUUZGRDVZeTdpdz0=",{"id":1676,"name":1677,"email":1678,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1679},324760,"Xuehu Duan","10431210431@stu.qlu.edu.cn","https://sciprofiles.com/profile/author/Tk4yUFRLZFRnQk1IMlJOd0hJTkc5bndFcHNrcUYvVllOSkd3S1RXeE4vZz0=",{"id":1681,"name":1682,"email":1683,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1684},324761,"Junmei Guo","gjm@qlu.edu.cn","https://sciprofiles.com/profile/author/QjNucWRxMkJCK2xuTEdIZEhCN3VnZz09",{"id":1686,"name":1687,"email":1688,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1689},324762,"Haiying Liu","haiyingliu2019@qlu.edu.cn","https://sciprofiles.com/profile/1514658",{"id":1691,"name":1692,"email":1693,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1694},324763,"Jason Gu","jason.gu@dal.ca","https://sciprofiles.com/profile/545463",{"id":1696,"name":1697,"email":1698,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1699},324764,"Lingyun Bi","10431210560@stu.qlu.edu.cn","https://sciprofiles.com/profile/3231556",{"id":1701,"name":1702,"email":1703,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1704},324765,"Haonan Chen","10431210436@stu.qlu.edu.cn","https://sciprofiles.com/profile/author/T3ZVSy9nTDNYcVhpWVNLR1pLSVZwWU95bkJPS3VEeW9ZMmtDcFF4UlFYQT0=",{"manuscript_id":1706,"manuscript_version":280,"hash_key":1707,"id":527,"version":280,"voted":47,"votes":7,"article_title":1708,"article_abstract":1709,"article_keywords":1710,"top_subject_name":87,"subject_name":1463,"article_type_name":140,"published_at":1711,"download_url":1712,"rank":53,"authors":1713},"202205.0194","d1a191b6907243aef90f8d76ede75f28","Comparison of Efficiency Based Optimal Load Distribution for Modular Ssts With Biologically Inspired Optimization Algorithms","The battle of currents between AC and DC reignited as a result of the development in the field of power electronics. The efficiency of DC distribution systems is highly dependent on the efficiency of distribution converter, which calls for optimized schemes for efficiency enhancement of distribution converters. Modular solid-state transformers play a vital role in DC Distribution Networks and Renewable Energy systems (RES).This paper deals with efficiency-based load distribution for Solid State Transformers (SSTs) in DC distribution networks. Aim is to achieve a set of minimum inputs that are consistent with output while considering constraints and efficiency. As the main feature of modularity is associated with a three-stage structure of SSTs. This modular structure has been optimized using Ant Lion Optimizer (ALO) and validated by applying it EIA (Energy Information Agency) DC Distribution Network which contains SSTs. In the DC distribution grid, modular SSTs provide promising conversion of DC power from medium voltage to lower DC range (400V). The proposed algorithm is simulated in MATLAB and also compared with two other metaheuristic algorithms. The obtained results prove that the proposed method can significantly reduce input requirements for producing the same output while satisfying the specified constraints.","Solid state transformer; Direct current; Renewable Energy Systems; Ant Lion Optimizer","2023-06-14 04:24:41","/frontend/manuscript/d1a191b6907243aef90f8d76ede75f28/download_pub",[1714,1719,1724,1730,1736,1742,1747,1753,1758],{"id":1715,"name":1716,"email":1717,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1718},354351,"Mariam Mughees","mariammughees@uet.edu.pk","https://sciprofiles.com/profile/author/dzNEZTFLUjVGNVNQV05kVmVxUi9vVk1lN3VKMkF3V1VXRzFSdWFVZGRFND0=",{"id":1720,"name":1721,"email":1722,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1723},354352,"Munazza Sadaf","munazzasadaf@uet.edu.pk","https://sciprofiles.com/profile/author/c0NVWjJIc0NKQlc4ZjBJNXpyREtJRVNaNnI4ZnRKL1IrR1MwVkRFV0VWTT0=",{"id":1725,"name":1726,"email":1727,"is_corresponding":6,"orcid_link":1728,"author_mark":266,"sp_link":1729},354353,"Hasan Erteza Gelani","erteza.gelani@uet.edu.pk","https://orcid.org/0000-0002-3307-5899","https://sciprofiles.com/profile/550185",{"id":1731,"name":1732,"email":1733,"is_corresponding":47,"orcid_link":1734,"author_mark":148,"sp_link":1735},354354,"Abdullah Bilal","2016ee368@student.uet.edu.pk","https://orcid.org/0000-0003-1603-8305","https://sciprofiles.com/profile/2235314",{"id":1737,"name":1738,"email":1739,"is_corresponding":6,"orcid_link":1740,"author_mark":266,"sp_link":1741},354355,"Faisal Saeed","19060005@lums.edu.pk","https://orcid.org/0000-0002-2260-5997","https://sciprofiles.com/profile/1408658",{"id":1743,"name":1744,"email":1745,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1746},354356,"MD. Shahariar Chowdhury","mdshahariar.c@psu.ac.th","https://sciprofiles.com/profile/1562332",{"id":1748,"name":1749,"email":1750,"is_corresponding":6,"orcid_link":1751,"author_mark":266,"sp_link":1752},354357,"Kuaanan Techato","kuaanan.t@psu.ac.th","https://orcid.org/0000-0002-9178-8416","https://sciprofiles.com/profile/411647",{"id":1754,"name":1755,"email":1756,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1757},354358,"Sittiporn Channumsin","sittiporn@gistda.or.th","https://sciprofiles.com/profile/829698",{"id":1759,"name":1760,"email":1761,"is_corresponding":47,"orcid_link":1762,"author_mark":148,"sp_link":1763},354359,"Nasim Ullah","nasimullah@tu.edu.sa","https://orcid.org/0000-0001-7208-6374","https://sciprofiles.com/profile/855920",{"category":93,"manuscripts":1765},[1766,1814,1857,1902,1924,1980,2020,2153,2190,2216],{"manuscript_id":1767,"manuscript_version":7,"hash_key":1768,"id":1769,"version":7,"voted":47,"votes":1770,"article_title":1771,"article_abstract":1772,"article_keywords":1773,"top_subject_name":93,"subject_name":1774,"article_type_name":140,"published_at":1775,"download_url":1776,"rank":7,"authors":1777},"202302.0390","9bfefa9d17281e6464ba6bcd17a92ed2",11,83,"Understanding Landslide Expression in SAR Backscatter Data: A Global Study","During disaster response, clouds or darkness can prevent the use of optical images for detecting consequences of natural disasters, including landslides. In these situations, radar images can be used to detect changes more rapidly. However, Synthetic Aperture Radar (SAR) backscatter intensity images are underutilized for landslide detection. Unfortunately, there remains a lack of understanding about how to interpret landslide signatures in SAR imagery. In this study, we investigate how the morphometric features and material properties of landslides, and preexisting land cover, control their expression in SAR backscatter intensity change images. Trends in the spatial and temporal signatures of over 1000 landslides in 30 diverse case studies are investigated, using multi-temporal composites and dense time-series of Sentinel-1 C-band SAR backscatter intensity data. The results show that the orientation of landslide surfaces relative to the sensor, pre-existing land cover, and the roughness of the landslide surface, determine whether landslides will produce an increase or decrease in backscatter intensity values. In certain cases, we can identify morphometric features of landslides (e.g. scarps, transit zone, deposits, ponding) and material properties. Generally, we see that landslides appear most clearly with a strong increase in intensity when they occur in herbaceous vegetation or non-vegetated ground surfaces, due to an increase in surface roughness. While in forested or densely vegetated areas, landslides produce a more complex signature with both decreases due to radar shadow and vegetation removal, and an adjacent edge of increased intensity due to double bounce and direct return from vertical tree trunks and convex edges. In most cases, rough deposits produce an increase in intensity, while smooth deposits (e.g. from mudslides) exhibit specular reflection, and thus show decreased values. Landslides are less visible in cases with pre-event very rough ground, or mixed vegetation conditions. The conceptual model developed can aid interpretation of landslides in SAR imagery, and provide domain knowledge needed to train models for automatic landslide detection.","change detection; time-series; landslide detection; land cover; Sentinel-1; backscatter; Google Earth Engine;","Geophysics and Geology","2023-02-22 15:33:14","/frontend/manuscript/9bfefa9d17281e6464ba6bcd17a92ed2/download_pub",[1778,1783,1788,1793,1799,1804,1809],{"id":1779,"name":1780,"email":1781,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1782},317972,"Erin Lindsay","erin.lindsay@ntnu.no","https://sciprofiles.com/profile/868414",{"id":1784,"name":1785,"email":1786,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1787},317973,"Alexandra Jarna Ganerød","alexandra.jarna@ntnu.no","https://sciprofiles.com/profile/author/SEphVVlKTkUvb0F4RlpSSTVUTlRVOVNHYmR4T2hyaDdIREp3bWJrOE5lND0=",{"id":1789,"name":1790,"email":1791,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1792},317974,"Graziella Devoli","g.de@nve.no","https://sciprofiles.com/profile/author/RHhVdmRVMGNjMGR4YlRzU1U1V0piQT09",{"id":1794,"name":1795,"email":1796,"is_corresponding":47,"orcid_link":1797,"author_mark":148,"sp_link":1798},317975,"Johannes Reiche","johannes.reiche@wur.nl","https://orcid.org/0000-0002-4327-4349","https://sciprofiles.com/profile/96926",{"id":1800,"name":1801,"email":1802,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1803},317976,"Steinar Nordal","steinar.nordal@ntnu.no","https://sciprofiles.com/profile/author/cFAzVHRvU0R6OFRhWWFieUhFNnErQUQ4YmFxZHJuZStKaDM2VnVXQ2dUST0=",{"id":1805,"name":1806,"email":1807,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1808},317977,"Regula Frauenfelder","regula.frauenfelder@ngi.no","https://sciprofiles.com/profile/766523",{"id":1810,"name":1811,"email":1812,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1813},317978,"Lars-Christian Tokle","lars-christian.n.tokle@ntnu.no","https://sciprofiles.com/profile/author/U2F1NHJuak4rSERsZXNsUGRpbVh0b0dwSVBWOU9Lall1c1hsTU96alRtYz0=",{"manuscript_id":1815,"manuscript_version":7,"hash_key":1816,"id":1817,"version":7,"voted":47,"votes":308,"article_title":1818,"article_abstract":1819,"article_keywords":1820,"top_subject_name":93,"subject_name":1821,"article_type_name":140,"published_at":1822,"download_url":1823,"rank":280,"authors":1824},"202310.2060","c42e745e776f9eb35ad4fd3daa812d79",13,"Production of High-Resolution Map of Biomass Carbon over Forests in Malaysia Estimated using Aboveground Carbon Density Indicator (ACDI) and a Collection of 12 Years Inventory Data","The accurate estimation of biomass carbon in forests is of paramount importance for effective forest management and mitigating climate change. This study presents a novel approach to produce a high-resolution map of biomass carbon over forests in Malaysia using the Aboveground Carbon Density Indicator (ACDI) and a comprehensive collection of 12 years of inventory data, i.e., from 2012 to 2023. The ACDI was derived based on several vegetation indices (VIs) that were produced from the original Landsat images to indicate the level of aboveground biomass carbon (AGC) stock in the forested areas. The VIs includes Normalised Difference Vegetation Index (NDVI), Normalised Burn Ratio (NBR), Shadow Index (SI), Soil-Adjusted Vegetation Index (SAVI), Iron Oxide Index (IO), Modified Normalised Difference Water Index (NDWI), and Enhanced Vegetation Index (EVI). The ACDI was then integrated with ground-based measurements, and serves as a robust indicator for estimating AGC. This calculation was conducted on Google Earth Engine (GEE) platform to match the date of field observation with the satellite imagery datasets. The production of seamless mosaic of the latest date of Landsat imagery and the forest type classification were also performed on GEE. The forested areas were classified into three major types, which are dry inland forest, mangrove forest, and peat swamp forest. Results indicated significant spatial variations in AGC across Malaysia's forests. The derived AGC prediction models based on the ACDI varied among the forest types. Based on the estimates, a 30-metre resolution, wall-to-wall map of AGC across the entire forested region of Malaysia has been created. The ACDI was calibrated and validated using a separate validation plots dataset to ensure the accuracy of the AGC estimates. The total AGC in all types of forests in Malaysia was estimated at 3.0 billion Mg C with an attainable accuracy of about 80%. These estimates were also divided into categories and reported to the AGC at the state level. This high-resolution map provides essential information for various stakeholders, with critical implications for carbon sequestration efforts, conservation priorities, and sustainable forest management. The presented methodology not only showcases the value of combining advanced remote sensing techniques with long-term inventory data but also underscores the potential for similar approaches in other tropical forest regions globally. Ultimately, this study contributes to the understanding of carbon dynamics in Malaysian forests and promotes effective strategies for mitigating climate change through better-informed forest conservation and management practices.","Aboveground carbon stock; tropical forest; Landsat; Malaysia ecosystem; spectral indicators","Remote Sensing","2023-10-31 09:56:37","/frontend/manuscript/c42e745e776f9eb35ad4fd3daa812d79/download_pub",[1825,1831,1837,1842,1847,1852],{"id":1826,"name":1827,"email":1828,"is_corresponding":6,"orcid_link":1829,"author_mark":266,"sp_link":1830},418980,"Hamdan Omar","hamdanomar@frim.gov.my","https://orcid.org/0000-0002-8565-1122","https://sciprofiles.com/profile/208691",{"id":1832,"name":1833,"email":1834,"is_corresponding":47,"orcid_link":1835,"author_mark":148,"sp_link":1836},418981,"Muhamad Afizzul Misman","afizzul@frim.gov.my","https://orcid.org/0000-0002-3351-6543","https://sciprofiles.com/profile/273696",{"id":1838,"name":1839,"email":1840,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1841},418982,"Valeria Linggok","valeria.linggok@sabah.gov.my","https://sciprofiles.com/profile/author/SFlqV1JXU2k1NDlRRE9sMHRxQ0c4RmhEalIzNTNFNGdPZkZpQkd3QlpRYz0=",{"id":1843,"name":1844,"email":1845,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1846},418983,"Suhaini Haron","suhaini@myforestfund.com.my","https://sciprofiles.com/profile/author/aFJGclVFUm9XRUV3TS92QWk4VVNSSFlMTWcyejByRWFXelhuMDM4ektrMD0=",{"id":1848,"name":1849,"email":1850,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1851},418984,"Ahmad Ashrin Mohd Bohari","ahmadam@sarawak.gov.my","https://sciprofiles.com/profile/author/Z0s0OUwxdmZ6Vll2eURNSHk0MzFhU3hHOTlQck1oOE1Od1doTnQrVHlTWT0=",{"id":1853,"name":1854,"email":1855,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1856},418985,"Mohammad Nor Firdaus Haji Sariee","mohdnorf@sarawak.gov.my","https://sciprofiles.com/profile/3268532",{"manuscript_id":1858,"manuscript_version":7,"hash_key":1859,"id":1860,"version":7,"voted":47,"votes":1861,"article_title":1862,"article_abstract":1863,"article_keywords":1864,"top_subject_name":93,"subject_name":1865,"article_type_name":140,"published_at":1866,"download_url":1867,"rank":53,"authors":1868},"202312.2073","8404dffeacae2fa3d3a16e6a3f1eca0b",15,37,"Hydroquinone Ecotoxicity: Unveiling Risks in Soil and River Ecosystems with Insights into Microbial Resilience","Despite widespread industrial use, the environmental safety of Hydroquinone (HQ), a benzene compound from plants used in processes like cosmetics, remains uncertain. This study evaluated the ecotoxicological impact of HQ on soil and river environments, utilizing non-target indicator organisms from diverse trophic levels: Daphnia magna, Vibrio fischeri, Allium cepa, and Eisenia fetida. For a more environmentally realistic assessment, microbial communities from a river and un-treated soil underwent 16S rRNA gene sequencing, with growth and changes in community-level physiological profiling assessed using Biolog EcoPlate™ assays. The water indicator D. magna exhibited the highest sensitivity to HQ (EC50 = 0.142 µg/mL), followed by V. fischeri (EC50 = 1.446 µg/mL), and A. cepa (LC50 = 7.631 µg/mL), while E. fetida showed the highest resistance (EC50 = 234 mg/Kg). Remarkably, microbial communities mitigated HQ impact in both aquatic and terrestrial environments. River microorganisms displayed minimal inhibition, except for a significant re-duction in polymer metabolism at the highest concentration (100 µg/mL). Soil communities demonstrated resilience up to 100 µg/mL, beyond which there was a significant decrease in population growth and the capacity to metabolize carbohydrates and polymers. Despite microbial mitigation, HQ remains highly toxic to various trophic levels, emphasizing the necessity for en-vironmental regulations.","Hydroquinone; acute toxicity; Daphnia magna; Vibrio fischeri; Allium cepa; Eisenia fetida; microbial communities","Environmental Science","2023-12-27 09:13:42","/frontend/manuscript/8404dffeacae2fa3d3a16e6a3f1eca0b/download_pub",[1869,1874,1879,1885,1890,1896],{"id":1870,"name":1871,"email":1872,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1873},445291,"Antonio Valenzuela","avalenzuela@usj.es","https://sciprofiles.com/profile/3310593",{"id":1875,"name":1876,"email":1877,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1878},445292,"Diego Ballestero","dballestero@usj.es","https://sciprofiles.com/profile/3572980",{"id":1880,"name":1881,"email":1882,"is_corresponding":47,"orcid_link":1883,"author_mark":148,"sp_link":1884},445293,"Cristina Gan","cgan@usj.es","https://orcid.org/0000-0002-0730-4053","https://sciprofiles.com/profile/2713748",{"id":1886,"name":1887,"email":1888,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1889},445294,"Guillermo Lorca","glorca@usj.es","https://sciprofiles.com/profile/3181258",{"id":1891,"name":1892,"email":1893,"is_corresponding":47,"orcid_link":1894,"author_mark":148,"sp_link":1895},445295,"Elisa Langa","elanga@usj.es","https://orcid.org/0000-0003-3061-2705","https://sciprofiles.com/profile/1195793",{"id":1897,"name":1898,"email":1899,"is_corresponding":6,"orcid_link":1900,"author_mark":266,"sp_link":1901},445296,"Mª Rosa Pino-Otín","rpino@usj.es","https://orcid.org/0000-0002-3186-1722","https://sciprofiles.com/profile/2230897",{"manuscript_id":1903,"manuscript_version":132,"hash_key":1904,"id":1064,"version":132,"voted":47,"votes":1905,"article_title":1906,"article_abstract":1907,"article_keywords":1908,"top_subject_name":93,"subject_name":1909,"article_type_name":140,"published_at":1910,"download_url":1911,"rank":53,"authors":1912},"202304.0198","73d7200b13568a0244d40298db90f0e1",17,"Elementary Steps in Steady State Kinetic Model Approximation for the Homo-Heterogeneous Photocatalysis of Carbamazepine","Elucidating physicochemical processes in the degradation of pollutants may optimize their removal from water sources. This work presents a set of elementary steps in the photocatalytic degradation of carbamazepine (CBZ), assuming a steady state approximation in an Advanced Oxidation Process (AOP) combining short-wave ultraviolet radiation (UVC), homogeneous reagent (H\u003Csub>2\u003C/sub>O\u003Csub>2\u003C/sub>) and heterogeneous (TiO\u003Csub>2\u003C/sub>) catalyst. Elementary steps include excitation of both reagent/catalysts by UVC photons, adsorption of CBZ on the excited TiO\u003Csub>2\u003C/sub>, or its oxidation by hydroxyl radicals. Assuming the steady state approximation on the intermediate products (excited TiO\u003Csub>2\u003C/sub>, CBZ- excited TiO\u003Csub>2\u003C/sub> complex, and hydroxyl radicals), leads to rate laws for degradation of CBZ, in which UVC radiation, TiO\u003Csub>2\u003C/sub>, and H\u003Csub>2\u003C/sub>O\u003Csub>2 \u003C/sub>are pseudo first order at all concentrations or intensities having no direct influence on CBZ pseudo-order, whereas CBZ shifts from pseudo first order at low concentrations to pseudo-zero order at high concentrations. Several experiments to test the mechanism were conducted, by varying CBZ, H\u003Csub>2\u003C/sub>O\u003Csub>2\u003C/sub>, and TiO\u003Csub>2\u003C/sub> concentrations, and UVC radiation intensities. Measured results indeed fit the suggested mechanism for the first three, but irradiation intensity appears to shift CBZ influence from pseudo-second to pseudo-first order with increased intensities. Corrected elementary steps are proposed to fit the results. ","carbamazepine; advanced oxidation process; pseudo-order; rate law; half life time; elementary steps; steady-state approximation","Water Science and Technology","2023-05-15 03:36:34","/frontend/manuscript/73d7200b13568a0244d40298db90f0e1/download_pub",[1913,1919],{"id":1914,"name":1915,"email":1916,"is_corresponding":6,"orcid_link":1917,"author_mark":266,"sp_link":1918},338998,"Giora Rytwo","rytwo@telhai.ac.il","https://orcid.org/0000-0002-4721-6031","https://sciprofiles.com/profile/1926829",{"id":1920,"name":1921,"email":1922,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1923},338999,"Yuval Shahar","yuvalsha1991@gmail.com","https://sciprofiles.com/profile/author/djNBcngzaDh3U2x4bUEyMmlMb0JxWEJoWmsyTHoxUndocWtwYmRVVGJXaz0=",{"manuscript_id":1925,"manuscript_version":7,"hash_key":1926,"id":58,"version":7,"voted":47,"votes":1905,"article_title":1927,"article_abstract":1928,"article_keywords":1929,"top_subject_name":93,"subject_name":1821,"article_type_name":140,"published_at":1930,"download_url":1931,"rank":53,"authors":1932},"202304.1131","3aae9c07ff899d19c773ce42b063686a","Quantifying Grassland Biomass and Regenerative Grazing Using Satellite Remote Sensing and Machine Learning","The emergence of cloud computing, big data analytics, and machine learning has catalysed the use of remote sensing technologies to enable more timely land management of sustainability indicators such as ground cover and grassland biomass, given the uncertainty of future climate and drought conditions. Here, we examine the potential of “regenerative agriculture”, as an adaptive grazing management strategy to minimise bare ground exposure while maximising pasture biomass productivity. High-intensity sheep grazing treatments were conducted in small fields (less than 1 hectare) for short durations (typically less than 1 day). Paddocks were subsequently spelled to allow pasture biomass recovery (treatments comprising 3, 6, 9, 12, and 15 months) with each compared with control treatments with lighter stocking rates for longer periods (2,000 DSE). Pastures were composed of wallaby grass (Austrodanthonia species), kangaroo grass (Themeda triandra), Phalaris (Phalaris aquatica, and cocksfoot (Dactylis glomerata) were destructively sampled to estimate total standing dry matter (TSDM), standing green biomass, standing dry biomass and trampled biomass. We then invoked a machine learning model using Sentinel-2 imagery to quantify TSDM, standing green biomass and standing dry biomass. Faced with La Nina conditions, regenerative grazing did not significantly impact pasture productivity, with all treatments showing similar TSDM and green biomass. However, regenerative treatments significantly impacted litter fall and trampled material, with the high intensity grazing treatments causing more dry matter trampling, increasing litter, enhancing decomposition rates and surface organic matter. Pasture digestibility was greatest for treatments with minimal spelling (3 months), whereas both standing senescent and trampled material were significantly greater for the treatment with 15-month spell periods. Estimates of TSDM using machine learning with Sentinel-2 imagery underestimated TSDM in treatment plots but explained spatiotemporal variability associated within and across treatments. The root mean square error between the measured and modelled TSDM was 903 kg DM/ha, which was less than the variability measured in the field. We conclude that regenerative grazing with short recovery periods (3-6 months) are most conducive to increasing pasture production under high rainfall conditions, and we speculate that high intensity grazing is likely to positively impact on soil organic carbon through increased litterfall and trampling. Our study paves the way forward for using machine learning with satellite imagery to quantify pasture biomass at small scales, enabling management of pastures from afar.","remote sensing; machine learning; regenerative grazing; grassland biomass; total standing dry matter; digital agriculture; grazing management; climate change; Cibo Labs; Sentinel-2","2023-04-28 07:15:03","/frontend/manuscript/3aae9c07ff899d19c773ce42b063686a/download_pub",[1933,1938,1943,1949,1954,1959,1964,1969,1974],{"id":1934,"name":1935,"email":1936,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1937},332057,"Michael Gbenga Ogungbuyi","michael.ogungbuyi@utas.edu.au","https://sciprofiles.com/profile/2664061",{"id":1939,"name":1940,"email":1941,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1942},332058,"Juan Pablo Guerschman","jguerschman@cibolabs.com.au","https://sciprofiles.com/profile/931930",{"id":1944,"name":1945,"email":1946,"is_corresponding":47,"orcid_link":1947,"author_mark":148,"sp_link":1948},332059,"Andrew Martin Fischer","andy.fischer@utas.edu.au","https://orcid.org/0000-0001-5284-6428","https://sciprofiles.com/profile/242050",{"id":1950,"name":1951,"email":1952,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1953},332060,"Richard Azu Crabbe","rcrabbe@csu.edu.au","https://sciprofiles.com/profile/author/eEVoUHlkNWMxekVnT2g1c1ZRb09aUm5WcFJtREZoUTRLVEswUlNxNUJGRT0=",{"id":1955,"name":1956,"email":1957,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1958},332061,"Caroline Mohammed","caroline.mohammed@utas.edu.au","https://sciprofiles.com/profile/836173",{"id":1960,"name":1961,"email":1962,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1963},332062,"Peter Scarth","pscarth@cibolabs.com.au","https://sciprofiles.com/profile/author/MDBFM3JES0J2aHB1ZHQwWWJVZzFRcjJkWE1qbWtDWGVGZVJEQll3QmFHWT0=",{"id":1965,"name":1966,"email":1967,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1968},332063,"Phil Tickle","ptickle@cibolabs.com.au","https://sciprofiles.com/profile/author/a0ViNGJsQkpnbHBkcURDT0h1ODBQNjJ4MDZub0N3aVU0cE45eWFDVk5DQT0=",{"id":1970,"name":1971,"email":1972,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1973},332064,"Jason Whitehead","jm_whitehead@hotmail.com","https://sciprofiles.com/profile/author/elF4WjF0R1VNTUZyb3FaRWgwZTJQdjIrMWNMVWJZL0JweHRoYXVYOFIrMD0=",{"id":1975,"name":1976,"email":1977,"is_corresponding":6,"orcid_link":1978,"author_mark":266,"sp_link":1979},332065,"Matthew Tom Harrison","matthew.harrison@utas.edu.au","https://orcid.org/0000-0001-7425-452X","https://sciprofiles.com/profile/372365",{"manuscript_id":1981,"manuscript_version":7,"hash_key":1982,"id":1034,"version":7,"voted":47,"votes":1769,"article_title":1983,"article_abstract":1984,"article_keywords":1985,"top_subject_name":93,"subject_name":1986,"article_type_name":140,"published_at":1987,"download_url":1988,"rank":53,"authors":1989},"202308.0314","c0bd5b7ba1df2f4c0b20a3e67c892e72","Modelled Multidecadal Trends of Lightning and (Very) Large Hail in Europe and North America (1950–2021)","\u003Cspan>We have developed additive logistic models for the occurrence of lightning, large (≥ 2 cm), and very large (≥ 5 cm) hail to investigate the evolution of these hazards in the past, in the future, and for forecasting applications. The models, trained with lightning observations, hail reports, and predictors from atmospheric reanalysis, assign an hourly probability to any location and time on a 0.25° × 0.25° × 1-hourly grid as a function of reanalysis-derived predictor parameters, selected following an ingredients- based approach. The resulting hail models outperform the Significant Hail Parameter and the simulated climatological spatial distributions and annual cycles of lightning and hail are consistent with observations from storm report databases, radar, and lightning detection data. As a corollary result, CAPE released above the -10°C isotherm was found to be a more universally skilful predictor for large hail than CAPE. In the period 1950–2021, the models applied to the ERA5 reanalysis indicate significant increases of lightning and hail across most of Europe, primarily due to rising low-level moisture. The strongest modelled hail increases occur in northern Italy with increasing rapidity after 2010. Here, very large hail has become 3 times more likely than it was in the 1950s. Across North America trends are comparatively small, apart from isolated significant increases in the direct lee of the Rocky Mountains and across the Canadian Plains. In the southern Plains, a period of enhanced storm activity occurred in the 1980s and 1990s.\u003C/span>","Hail; Lightning; Climate change; Regression analysis; Trends; Reanalysis data","Atmospheric Science and Meteorology","2023-08-03 10:07:40","/frontend/manuscript/c0bd5b7ba1df2f4c0b20a3e67c892e72/download_pub",[1990,1995,2000,2005,2010,2015],{"id":1991,"name":1992,"email":1993,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":1994},378816,"Francesco Battaglioli","francesco.battaglioli@essl.org","https://sciprofiles.com/profile/3083930",{"id":1996,"name":1997,"email":1998,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":1999},379684,"Pieter Groenemeijer","pieter.groenemeijer@essl.org","https://sciprofiles.com/profile/author/Mk5Ld1gvYXFwQ3NENUJKeDVON01wbE5PVi8wcmMwazdiUkliTTNLYVFpQT0=",{"id":2001,"name":2002,"email":2003,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2004},379685,"Tomas Pucik","tomas.pucik@essl.org","https://sciprofiles.com/profile/1100008",{"id":2006,"name":2007,"email":2008,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2009},379686,"Mateusz Taszarek","mateusz.taszarek@amu.edu.pl","https://sciprofiles.com/profile/author/NEpOSEd4bFBVK040dmdEVHpLaUpobHZmL1k3Z3hZc3JRVFhlY2xBQk5UUT0=",{"id":2011,"name":2012,"email":2013,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2014},379687,"Uwe Ulbrich","ulbrich@met.fu-berlin.de","https://sciprofiles.com/profile/author/T0ZITklmZjVzcEVyRjdsTTg5VlpxZGg4d1oyQndnK3M2SCtwQk10bWdvND0=",{"id":2016,"name":2017,"email":2018,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2019},379688,"Henning Rust","henning.rust@fu-berlin.de","https://sciprofiles.com/profile/author/MEY4Q0k0Vnl6Zk95TG54eVZ0bEcwZWlXVjBRU05DMjlSMVVBRjl3MWUvYz0=",{"manuscript_id":2021,"manuscript_version":7,"hash_key":2022,"id":1905,"version":7,"voted":47,"votes":5,"article_title":2023,"article_abstract":2024,"article_keywords":2025,"top_subject_name":93,"subject_name":2026,"article_type_name":140,"published_at":2027,"download_url":2028,"rank":53,"authors":2029},"202309.1827","6520e2f62d98c44e6d184dca72319fda","Conservation Imperatives: Securing the Last Unprotected Terrestrial Sites Harboring Irreplaceable Biodiversity","Ambitious biodiversity goals to protect 30% or more of the Earth’s surface by 2030 to prevent the most likely and imminent extinctions require strategic near-term targets. We propose Conservation Imperatives, spanning 164 Mha across 16,825 unprotected sites harboring rare and threatened species. These sites should be prioritized for conservation action over the next three to five years as part of a broader strategy to expand the global protected area network. The expansion of global protected areas between 2018–2023 incorporated only 7% of sites harboring range-limited and threatened species, highlighting a renewed urgency to conserve these habitats. Permanently protecting only 0.74% of land found in the tropics, where Conservation Imperatives sites are concentrated, at a cost of US$34 to $56 billion per year over the next 3-5 years, could prevent the majority of predicted near-term extinctions once adequately resourced. Multiple approaches could achieve this goal: providing rights and title to Indigenous Peoples and Local Communities (IPLCs) conserving traditional lands, government designation of new protected areas on federal and state lands; or land purchase and long-term leasing of privately held lands.","Conservation imperatives; 30 by 30; Protected area targets; Rare species; Land cover fraction mapping; Geospatial analysis; Land costs analysis","Ecology","2023-09-28 03:31:14","/frontend/manuscript/6520e2f62d98c44e6d184dca72319fda/download_pub",[2030,2035,2040,2045,2051,2056,2061,2067,2072,2077,2082,2087,2092,2098,2103,2108,2113,2118,2123,2128,2133,2138,2143,2148],{"id":2031,"name":2032,"email":2033,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":2034},402670,"Eric Dinerstein","edinerstein@resolve.ngo","https://sciprofiles.com/profile/author/TXRYS3BNd1dNNmNDVjZDZjNjdVpuTDVvOWwzSkNnV0NwVGtyUVNIRnFxND0=",{"id":2036,"name":2037,"email":2038,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2039},402671,"Anup R. Joshi","joshi002@umn.edu","https://sciprofiles.com/profile/217003",{"id":2041,"name":2042,"email":2043,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2044},402672,"Nathan R. Hahn","nhahn@resolve.ngo","https://sciprofiles.com/profile/author/ZnhNYlRHbTFBWTBUTUVCUmxHNThhOHEvZ2VJZzNKZlg4YWIycytRZHZvTT0=",{"id":2046,"name":2047,"email":2048,"is_corresponding":47,"orcid_link":2049,"author_mark":148,"sp_link":2050},402673,"Andy T. L. Lee","alee@resolve.ngo","https://orcid.org/0000-0002-2869-5460","https://sciprofiles.com/profile/3171108",{"id":2052,"name":2053,"email":2054,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2055},402674,"Carly Vynne","cvynne@resolve.ngo","https://sciprofiles.com/profile/author/Q3lnRERVR0hka3VTK1pERDU5dTFUQU9JV1UvQjhSVzdzRWUwTXAxWGNpWT0=",{"id":2057,"name":2058,"email":2059,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2060},402675,"Karl Burkart","karl@oneearth.org","https://sciprofiles.com/profile/author/d1FqZVNwaW52K1kzZnVmVkpySWFCNW95LzJRVThRVUUzN3lkR01heVBPdz0=",{"id":2062,"name":2063,"email":2064,"is_corresponding":47,"orcid_link":2065,"author_mark":148,"sp_link":2066},402676,"Greg P. Asner","gregasner@asu.edu","https://orcid.org/0000-0001-7893-6421","https://sciprofiles.com/profile/101346",{"id":2068,"name":2069,"email":2070,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2071},402677,"Charlotte Beckham","charlotte.beckham@worldlandtrust.org","https://sciprofiles.com/profile/author/YXo1MmtrK2JvVWhiUzNZb0lMZFErRTBRcnJHSDNMS2Z5aGtSY2ozWWxvcDBBMllMemY4dEJmZ2kxNExKKzhneQ==",{"id":2073,"name":2074,"email":2075,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2076},402678,"Gerardo Ceballos","ceballos.gerardo58@gmail.com","https://sciprofiles.com/profile/author/TlpjV2kvS2VSWDhrbWZnS0ZHYTRtdFpSL1dnSXkvREY0RFFRTzFiZ3JSUT0=",{"id":2078,"name":2079,"email":2080,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2081},402679,"Richard Cuthbert","richard_cuthbert@yahoo.co.uk","https://sciprofiles.com/profile/author/OVRMWmF5amVwU3BVdUpaRmxDVzFUcnNydlcyeHo1T3NGWjVLd3o5R0FCND0=",{"id":2083,"name":2084,"email":2085,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2086},402680,"Rodolfo Dirzo","rdirzo@stanford.edu","https://sciprofiles.com/profile/1345872",{"id":2088,"name":2089,"email":2090,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2091},402681,"Oliver Fankem","oliverfankem@globalconservation.org","https://sciprofiles.com/profile/author/TTNNdDlYeDRaUzBTUTA4UW5JTys4STRHSm5GTXRLNDRqZ0lQV1ZwQVR6QUF1NHB2ZjZ5dHRGYUFhTWt3UnNWOQ==",{"id":2093,"name":2094,"email":2095,"is_corresponding":47,"orcid_link":2096,"author_mark":148,"sp_link":2097},402682,"Sarah Hertel","sarahmhertel@gmail.com","https://orcid.org/0000-0001-7073-8930","https://sciprofiles.com/profile/3409465",{"id":2099,"name":2100,"email":2101,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2102},402683,"Binbin V. Li","bl113@duke.edu","https://sciprofiles.com/profile/author/MmJEZW1wWmwyTFNRSjZiVE4rSkp3dz09",{"id":2104,"name":2105,"email":2106,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2107},402684,"Haley Mellin","haley@conserve.org","https://sciprofiles.com/profile/author/bW11aXE3RGdKa2N0dEUwT3VTZU9NNUZoODd5R3UxUDdhcmR5QTkyWEJpdz0=",{"id":2109,"name":2110,"email":2111,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2112},402685,"Felix Pharand-Deschênes","felix@globaia.org","https://sciprofiles.com/profile/author/ZTNFekN5S0dSTzdJZEZqRkl3elFXVVd5OWM0MDIxK0d1bnRGVXRyaDQ5TT0=",{"id":2114,"name":2115,"email":2116,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2117},402686,"David Olson","conservationearth@live.com","https://sciprofiles.com/profile/author/R2tzdzRWVDRoUSt3SGhIZ21JVlJNOTdZSUpjdlZINXdieUNNL2RWc1pYOD0=",{"id":2119,"name":2120,"email":2121,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2122},402687,"Bivash Pandav","bivash.pandav@wii.gov.in","https://sciprofiles.com/profile/author/T1REK011dDZWZDF5RU8veTA5NUs2ekZER3l1WitDd1AyMWVhMDFBdzJ6VT0=",{"id":2124,"name":2125,"email":2126,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2127},402688,"Carlos Peres","c.peres@uea.ac.uk","https://sciprofiles.com/profile/244411",{"id":2129,"name":2130,"email":2131,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2132},402689,"Rudi Putra","rhinoleuser@gmail.com","https://sciprofiles.com/profile/author/T2dZbXRqUStqbm9ONExLdUUxNFBnUUJCZ1ltandIejdvTnVpVXRwOTcxOD0=",{"id":2134,"name":2135,"email":2136,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2137},402690,"Amy Rosenthal","amy.rosenthal@planet.com","https://sciprofiles.com/profile/3181784",{"id":2139,"name":2140,"email":2141,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2142},402691,"Caspar Verwer","caspar.verwer@iucn.nl","https://sciprofiles.com/profile/author/cFNHczV0NmU5enhvZkR4a2ZqS2pQaTIrWjlFZGpMODBaeW5MOVlSdkRDVT0=",{"id":2144,"name":2145,"email":2146,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2147},402692,"Eric Wikramanayake","eric.wikramanayake@wwfus.org","https://sciprofiles.com/profile/author/MFdMeGFUa0JZMUZGZ3ZJMFBSb0g5S2ZhZHVVWXJDTC9HYURrYm5McHN0UT0=",{"id":2149,"name":2150,"email":2151,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2152},402693,"Andrew Zolli","andrew@planet.com","https://sciprofiles.com/profile/author/WXg2a3pNV1g5eUhUa3NXb1g4VXVtcWdwVkIwWGJRMC9mU3BVLzRlSnFXaz0=",{"manuscript_id":2154,"manuscript_version":7,"hash_key":2155,"id":1176,"version":7,"voted":47,"votes":752,"article_title":2156,"article_abstract":2157,"article_keywords":2158,"top_subject_name":93,"subject_name":1821,"article_type_name":140,"published_at":2159,"download_url":2160,"rank":53,"authors":2161},"202310.0214","89348fe5118550364ab10fe11cf2555a","Assessment of Bottom-Up Satellite Precipitation Products on River Streamflow Estimations in the Peruvian Pacific Drainage","In regions with limited precipitation information like Peru, many studies rely on precipitation data derived from satellite products (SPPs) and reanalysis products. These products provide near-real-time information and offer global spatial coverage, making them attractive for various applications. However, it is essential to consider their uncertainties when conducting hydrological simulations, especially in a key region like the Pacific drainage (Pd), where 56% of Peruvian population resides (including the capital Lima).\r\nThis study evaluates the performance of three precipitation products: Reanalysis, ERA5-Land (top down approach), and two SPPs: GPM+SM2RAIN and SM2RAIN-ASCAT (bottom-up approaches). Hydrological modeling was conducted on 30 basins distributed across the Pd, which were grouped into five regions (I-V, ordered from south to north). The results showed that SM2RAIN-ASCAT performed well in regions I-III-IV, ERA5-Land in region II, and GPM+SM2RAIN in region V. The hydrological model GR4J was tested, and better efficiency criteria were obtained with SM2RAIN-ASCAT and GPM+SM2RAIN when comparing simulated versus observed streamflows. The hydrological modeling with SM2RAIN-ASCAT and GPM+SM2RAIN demonstrated satisfactory efficiency metrics (KGE > 0.75; NSE > 0.65). Additionally, ten hydrological signatures were quantified to assess the variability of simulated streamflows in each basin, with metrics such as Mean Flow (Q mean), 5th Quantile Flow (Q5), and 95th Quantile Flow (Q95) showing overall better performance.\r\nFinally, the results of this study demonstrate the reliability of using bottom-up satellite products in Pd basins.","precipitation satellite products; bottom up; hydrological model; daily discharge; GR4J; Peruvian pacific drainage","2023-10-04 09:36:13","/frontend/manuscript/89348fe5118550364ab10fe11cf2555a/download_pub",[2162,2167,2173,2178,2184],{"id":2163,"name":2164,"email":2165,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":2166},407501,"Jonathan Qquenta","jonathan.qquenta@unmsm.edu.pe","https://sciprofiles.com/profile/3188786",{"id":2168,"name":2169,"email":2170,"is_corresponding":47,"orcid_link":2171,"author_mark":148,"sp_link":2172},407502,"Pedro Rau","prau@utec.edu.pe","https://orcid.org/0000-0002-1004-6729","https://sciprofiles.com/profile/1494399",{"id":2174,"name":2175,"email":2176,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2177},407503,"Luc Bourrel","luc.bourrel@ird.fr","https://sciprofiles.com/profile/2226774",{"id":2179,"name":2180,"email":2181,"is_corresponding":47,"orcid_link":2182,"author_mark":148,"sp_link":2183},407504,"Frédéric Frappart","frederic.frappart@inrae.fr","https://orcid.org/0000-0002-4661-8274","https://sciprofiles.com/profile/88442",{"id":2185,"name":2186,"email":2187,"is_corresponding":47,"orcid_link":2188,"author_mark":148,"sp_link":2189},407505,"Waldo Lavado-Casimiro","wlavado@senamhi.gob.pe","https://orcid.org/0000-0002-0051-0743","https://sciprofiles.com/profile/684386",{"manuscript_id":2191,"manuscript_version":7,"hash_key":2192,"id":2193,"version":7,"voted":47,"votes":752,"article_title":2194,"article_abstract":2195,"article_keywords":2196,"top_subject_name":93,"subject_name":1986,"article_type_name":314,"published_at":2197,"download_url":2198,"rank":53,"authors":2199},"202304.0786","92ef4966b2ff4ffc330e66f445c0abcb",14,"The Surprising Roles of Turbulence in Tropical Cyclone Physics","Tropical cyclones have long been known to be powered by turbulent enthalpy fluxes from the ocean surface and retarded by turbulent momentum fluxes into the surface. Here were review evidence that the development and structure of these storms are also partially controlled by turbulence in the outflow near the storm top. Finally, we present new research that shows that tropical cyclone-like, low-aspect-ratio vortices are most likely in systems in which the bottom heat flux is controlled by mechanical turbulence and the top boundary is insulating.","Tropical cyclone; hurricane; turbulence; convection; Rayleigh-Benard","2023-04-23 07:38:59","/frontend/manuscript/92ef4966b2ff4ffc330e66f445c0abcb/download_pub",[2200,2206,2211],{"id":2201,"name":2202,"email":2203,"is_corresponding":6,"orcid_link":2204,"author_mark":266,"sp_link":2205},329366,"Kerry Emanuel","emanuel@mit.edu","https://orcid.org/0000-0002-2066-2082","https://sciprofiles.com/profile/108050",{"id":2207,"name":2208,"email":2209,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2210},329367,"Martin Velez-Pardo","martinvp@mit.edu","https://sciprofiles.com/profile/author/V1ZWMmROd2MxWkhxS2tRbnM3V3dMdHJKWTRtdnE1RzlQYmkvc1QyYzd5RT0=",{"id":2212,"name":2213,"email":2214,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2215},329368,"Timothy W. Cronin","twcronin@mit.edu","https://sciprofiles.com/profile/author/OHpJQTMzcElWTmdmRGVueHl2eFFablZ5V3U1S2ExdjF2UUNtcDVBSm1lcz0=",{"manuscript_id":2217,"manuscript_version":7,"hash_key":2218,"id":2219,"version":7,"voted":47,"votes":1295,"article_title":2220,"article_abstract":2221,"article_keywords":2222,"top_subject_name":93,"subject_name":2223,"article_type_name":140,"published_at":2224,"download_url":2225,"rank":53,"authors":2226},"202305.1728","73ee8bc0cb23b63f718752f62ec81502",20,"Microstructures in Shocked Quartz: Linking Nuclear Airbursts and Meteorite Impacts","Many studies of hypervelocity impact craters have described the characteristics of quartz grains shock-metamorphosed at high pressures of >10 GPa, but in contrast, few studies have investigated shock metamorphism at lower shock pressures. In this study, we test the hypothesis that low-pressure shock metamorphism occurs in near-surface nuclear airbursts and that this process shares important characteristics with impact-cratering events. To investigate low-grade shock microstructures, we compared quartz grains from Meteor Crater, a 1.2-km-wide impact crater, to those from near-surface nuclear airbursts at the Alamogordo Bombing Range, New Mexico in 1945 and Kazakhstan in 1949/1953. This investigation utilized a comprehensive analytical suite of high-resolution techniques, including transmission electron microscopy (TEM) and electron backscatter diffraction (EBSD). Meteor Crater and the nuclear test sites all exhibit metamorphosed quartz grains with closely-spaced, sub-micron-wide fractures that appear to have formed at low shock pressures. Importantly, these micro-fractures are closely associated with Dauphiné twins and are filled with amorphous silica (glass), widely considered to be a classic indicator of shock metamorphism. Thus, this study confirms that glass-filled shock fractures in quartz form during near-surface nuclear airbursts, as well as crater-forming impact events, and by extension, it suggests they also may form in near-surface cosmic airbursts.","nuclear/atomic detonations; impact craters; shocked quartz; shock fractures; planar deformation features; planar fractures; tectonic deformation lamellae; electron backscatter diffraction (EBSD); transmission electron microscopy (TEM); cathodoluminescence (CL)","Space and Planetary Science","2023-05-25 03:47:36","/frontend/manuscript/73ee8bc0cb23b63f718752f62ec81502/download_pub",[2227,2232,2238,2243,2249,2254,2259,2264,2269,2274,2279,2284,2289,2294,2299,2304],{"id":2228,"name":2229,"email":2230,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2231},344074,"Robert E. Hermes","hermesrobb@gmail.com","https://sciprofiles.com/profile/author/aFltSUtlSnJEYmg0TDdJL01oQ3lFajJITWE3K0ZhQmFqQ2liS0VNSFJXRT0=",{"id":2233,"name":2234,"email":2235,"is_corresponding":47,"orcid_link":2236,"author_mark":148,"sp_link":2237},344075,"Hans-Rudolf Wenk","wenk@berkeley.edu","https://orcid.org/0000-0001-6641-7640","https://sciprofiles.com/profile/598140",{"id":2239,"name":2240,"email":2241,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2242},344076,"James P. Kennett","isotope@ucsb.edu","https://sciprofiles.com/profile/2886165",{"id":2244,"name":2245,"email":2246,"is_corresponding":47,"orcid_link":53,"author_mark":2247,"sp_link":2248},344077,"Ted E. Bunch","bunch.cometresearchgroup@gmail.com","#","https://sciprofiles.com/profile/author/bnBlRHRyRWoyYXZZcWRDUlcvQTR3bGhjZ0h6ODZUM0djNGZ3UG9CdXhSSURrcmRON3FHMWFWaXJRU1F1dkRYUQ==",{"id":2250,"name":2251,"email":2252,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2253},344078,"Christopher R. Moore","moorecr@mailbox.sc.edu","https://sciprofiles.com/profile/author/WXFBdHpMdDlaeWVEN1dJd2loQnB0ZGFxcTlOSllQWlhxK3BhSVpjekVJOD0=",{"id":2255,"name":2256,"email":2257,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2258},344079,"Malcolm A. LeCompte","ml118031@gmail.com","https://sciprofiles.com/profile/author/NE5IMldaejIrMk0zU2ZpbTErV2ZLR0s0SDlRclBmczA3ZFdLNWNsUU00QT0=",{"id":2260,"name":2261,"email":2262,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2263},344080,"Gunther Kletetschka","gkletetschka@alaska.edu","https://sciprofiles.com/profile/2709763",{"id":2265,"name":2266,"email":2267,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2268},344081,"A. Victor Adedeji","avadedeji@ecsu.edu","https://sciprofiles.com/profile/author/V3I4WHg4T3pkSjFNNWd3T1YwNUNDSzNMNEs0eDJ4bU1XTHhPQlo0ZmpnQT0=",{"id":2270,"name":2271,"email":2272,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2273},344082,"Kurt Langworthy","klangwor@uoregon.edu","https://sciprofiles.com/profile/author/aFU0akJ5ZXRLbmg1WGtTdDYvMkFiWVlVTlZzREY3cyt1d2dvOUl6L2JTZz0=",{"id":2275,"name":2276,"email":2277,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2278},344083,"Joshua J. Razink","jrazink@uoregon.edu","https://sciprofiles.com/profile/author/L3o4OWJvYkw0Z1JGTkxSKzBWbjJ0RG10QXJzRW50WXg3d1lhVnhldUwyVT0=",{"id":2280,"name":2281,"email":2282,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2283},344084,"Valerie Brogden","vbrogden@uoregon.edu","https://sciprofiles.com/profile/author/WUFxaytPcU8wbnRIQ3h6N25pWUdOSmgrNFhPYWdVenYwd3o5QlYwenBlWT0=",{"id":2285,"name":2286,"email":2287,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2288},344085,"Brian Van Devener","b.van-devener@utah.edu","https://sciprofiles.com/profile/author/cVV2Y1BPSnVVTUlqa3RqVnB2UlJGVWY2dHArR1Y4ZkMyckVYVnZwbXFDND0=",{"id":2290,"name":2291,"email":2292,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2293},344086,"Jesus Paulo Perez","jperez@eng.utah.edu","https://sciprofiles.com/profile/author/WFA1MHh3ZFZhZEtDNFZYSmRHNmViQk54Ti9aN0RPL3hHOTZoaXhnTXNtND0=",{"id":2295,"name":2296,"email":2297,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2298},344087,"Randy Polson","rcp7@utah.edu","https://sciprofiles.com/profile/author/NXBIVDRXUmxUeWtYQmt3U252MkQydz09",{"id":2300,"name":2301,"email":2302,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2303},344088,"Matt Nowell","matt.nowell@ametek.com","https://sciprofiles.com/profile/author/NkozVGxQejFweEtKSTc3UnlwUGxiWGVUK3lyWXV6MWVYdmRkazFhcGNQYz0=",{"id":2305,"name":2306,"email":2307,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":2308},344089,"Allen West","cometresearchgroup@gmail.com","https://sciprofiles.com/profile/2634583",{"category":107,"manuscripts":2310},[2311,2328,2343,2359,2375,2390,2405,2420,2436,2451],{"manuscript_id":2312,"manuscript_version":1334,"hash_key":2313,"id":270,"version":1334,"voted":47,"votes":2314,"article_title":2315,"article_abstract":2316,"article_keywords":2317,"top_subject_name":107,"subject_name":2318,"article_type_name":140,"published_at":2319,"download_url":2320,"rank":7,"authors":2321},"202207.0399","3a02dde90e4fb77693956a1cce6e2532",293,"Euclidean Relativity Solves 15 Mysteries of Physics","Special and general relativity (SR/GR) describe nature \u003Cem>subjectively.\u003C/em> Mathematically, they are correct. \u003Cstrong>Here I show: (1)\u003C/strong> Physically, SR/GR have an issue. Both theories describe nature from the perspective of just one observer each (one group of observers, to be exact). After a transformation, there is again just one active perspective. Because of this constraint, there is no holistic view of nature. The issue manifests itself in the fact that SR/GR have not solved several mysteries, such as the Hubble tension, dark energy, and non-locality. Still, SR/GR work well for each observer because the Lorentz factor and gravitational time dilation are correct. \u003Cstrong>(2)\u003C/strong> Euclidean relativity (ER) describes nature \u003Cem>objectively.\u003C/em> Any (!) object’s proper space \u003Cem>d\u003C/em>\u003Csub>1\u003C/sub>, \u003Cem>d\u003C/em>\u003Csub>2\u003C/sub>, \u003Cem>d\u003C/em>\u003Csub>3\u003C/sub> and its proper time \u003Cem>τ\u003C/em> span “natural spacetime”, which is 4D Euclidean space (ES) if we interpret \u003Cem>cτ\u003C/em> as \u003Cem>d\u003C/em>\u003Csub>4\u003C/sub>. All energy moves through ES at the speed of light \u003Cem>c\u003C/em>. Each observer’s reality is created by projecting ES orthogonally to his proper space and to his proper time. These two concepts are reassembled in SR/GR to a non-Euclidean spacetime. Since information is lost in each projection, the performance of SR/GR is limited. However, the SO(4) symmetry of ES is not compatible with waves. This is fine because ER tells us that wave and particle are subjective concepts: \u003Cem>What I deem wave, deems itself particle at rest.\u003C/em> We must distinguish between the master reality ES (without waves) and an observer’s reality (with waves). \u003Cstrong>I conclude:\u003C/strong> A holistic view of nature is a necessary requirement for solving the Hubble tension, dark energy, and non-locality.","spacetime; cosmology; Hubble constant; Hubble diagram; quantum mechanics","Theoretical Physics","2023-11-29 11:08:20","/frontend/manuscript/3a02dde90e4fb77693956a1cce6e2532/download_pub",[2322],{"id":2323,"name":2324,"email":2325,"is_corresponding":6,"orcid_link":2326,"author_mark":266,"sp_link":2327},431600,"Markolf H. Niemz","markolf.niemz@medma.uni-heidelberg.de","https://orcid.org/0000-0002-7305-4726","https://sciprofiles.com/profile/2352296",{"manuscript_id":2329,"manuscript_version":1123,"hash_key":2330,"id":7,"version":1123,"voted":47,"votes":1034,"article_title":2331,"article_abstract":2332,"article_keywords":2333,"top_subject_name":107,"subject_name":2318,"article_type_name":140,"published_at":2334,"download_url":2335,"rank":280,"authors":2336},"201711.0022","5dc1c9d1ef19a88fa30f5a8aa529d1cd","The Geometrization of Maxwell’s Equations and the Emergence of Gravity","Coupling the Maxwell tensor to the Riemann-Christoffel curvature tensor is shown to lead to a geometricized theory of electrodynamics. While this geometricized theory leads directly to the classical Maxwell equations, it also extends their interpretation by giving charge density and mass density, and the four-velocity that describes their motion geometric definitions. These geometric definitions are reminiscent of General Relativity’s interpretation of mass in terms of the scalar curvature \u003Cem>R\u003C/em> and hint at the emergence of gravity. The gravitational theory that does emerge is shown to be equivalent to Einstein’s General Relativity augmented by an energy-momentum tensor term that mimics the properties of dark matter and/or dark energy. In summary, the proposed geometrization of the Maxwell tensor puts both electromagnetic and gravitational phenomena on an equal footing with both being tied to the curvature of space-time. Using specific solutions to the proposed theory, the unification brought to electromagnetic and gravitational phenomena, as well as the relationship of those solutions to the corresponding solutions of the classical Maxwell and Einstein field equations are compared.","Maxwell’s equations; General Relativity; unification of electromagnetism and gravity; dark matter and dark energy; electromagnetic and gravitational radiation; antimatter; antigravity; quantization; superluminal transport","2023-05-15 14:37:07","/frontend/manuscript/5dc1c9d1ef19a88fa30f5a8aa529d1cd/download_pub",[2337],{"id":2338,"name":2339,"email":2340,"is_corresponding":6,"orcid_link":2341,"author_mark":266,"sp_link":2342},339421,"Raymond Beach","beach2@llnl.gov","https://orcid.org/0000-0002-4099-130X","https://sciprofiles.com/profile/281334",{"manuscript_id":2344,"manuscript_version":280,"hash_key":2345,"id":1123,"version":280,"voted":47,"votes":1176,"article_title":2346,"article_abstract":2347,"article_keywords":2348,"top_subject_name":107,"subject_name":2349,"article_type_name":2350,"published_at":2351,"download_url":2352,"rank":53,"authors":2353},"202101.0056","78964bf24b110f9b994bd6bce06c4885","Einstein’s Dream: Realization and Failure","Several mathematicians and physicists are working all over the globe to get a unified theory. However, most of them are discarding Einstein’s view at the very first step of their theories. This article provides a brief description about this. Also, on the basis of Koga’s theory we point out two reasons which might have caused Einstein’s failure to get a unified theory.","deterministic theory; Einstein’s dream; electron; general relativity; quantum mechanics; quantum gravity; structure of matter; unified theory","Quantum Science and Technology","Short Note","2023-10-12 20:21:59","/frontend/manuscript/78964bf24b110f9b994bd6bce06c4885/download_pub",[2354],{"id":2355,"name":2356,"email":2357,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":2358},410656,"S K Pandey","skpandey12@gmail.com","https://sciprofiles.com/profile/1317131",{"manuscript_id":2360,"manuscript_version":1905,"hash_key":2361,"id":1295,"version":1905,"voted":47,"votes":1817,"article_title":2362,"article_abstract":2363,"article_keywords":2364,"top_subject_name":107,"subject_name":2365,"article_type_name":140,"published_at":2366,"download_url":2367,"rank":53,"authors":2368},"202201.0301","0247bf5ced190ec7f70b90a0608c31e5","Vacuum Expansion and Collapse Inside an Infinite Shell","The FRW model of cosmology assumes a Universe with uniform pressure and density everywhere in space at a given time. But at the largest scales, the Universe has a web-like structure surrounding large voids, violating these assumptions. Furthermore, a given region of spacetime is describable only by a single metric and therefore it cannot be that the Universe is modelled as an FRW perfect fluid since this would be the incorrect description of both the web and the voids. The cosmic web must be described by metrics with non-zero energy-momentum tensors with non-uniform pressure and density describing the matter within it. Therefore, the model of cosmology describing the expansion of the Universe must be a vacuum solution describing the empty spaces in the Universe surrounded by an infinite, massive shell (the surrounding Universe). The internal Schwarzschild metric is the model for these vacua. A detailed analysis of falling frames in the external metric in Kruskal-Szekeres coordinates shows that the source of the Schwarzschild metric is at the event horizon, a location/time of infinite density, not at the singularity, as it is currently assumed. The spatial homogeneity of the internal metric is demonstrated by visualizing the geometry in Kruskal-Szekeres coordinates (visualized in 1+2 dimensions) as well as examining the Killing vectors for the internal spacetime. Using the coordinate age of the Universe and transition redshift, this predicts the accelerated expansion, the Hubble diagram fits currently available cosmological data, and it gives a Hubble constant H\u003Csub>0\u003C/sub> of 71.6km/s/Mpc. The angular term of the metric describes the relativistic kinematic precession effect known as Thomas Precession which can be interpreted as spin about the time dimension.","Cosmology; Black holes; Dark Energy; Schwarzschild metric","Astronomy and Astrophysics","2023-07-24 08:08:52","/frontend/manuscript/0247bf5ced190ec7f70b90a0608c31e5/download_pub",[2369],{"id":2370,"name":2371,"email":2372,"is_corresponding":6,"orcid_link":2373,"author_mark":266,"sp_link":2374},373586,"Christopher Laforet","claforet@gmail.com","https://orcid.org/0000-0002-5492-5995","https://sciprofiles.com/profile/1924996",{"manuscript_id":2376,"manuscript_version":280,"hash_key":2377,"id":280,"version":280,"voted":47,"votes":5,"article_title":2378,"article_abstract":2379,"article_keywords":2380,"top_subject_name":107,"subject_name":2365,"article_type_name":140,"published_at":2381,"download_url":2382,"rank":53,"authors":2383},"202108.0159","4c7a58bbb30f1e8ffad8be5df991d410","On the Vacuum Energy of the Universe at the Galaxy Level, the Cosmological Level and the Quantum Level\u003Cstrong> \u003C/strong>","It is shown that the Lambda component in the cosmological Lambda-CDM model can be conceived as vacuum energy, consisting of gravitational particles subject to Heisenberg’s energy-time uncertainty. These particles can be modelled as elementary polarisable Dirac-type dipoles (“darks”) in a fluidal space at thermodynamic equilibrium, with spins that are subject to the Bekenstein-Hawking entropy. Around the baryonic kernels, uniformly distributed in the universe, the spins are polarized, thereby invoking an increase of the effective gravitational strength of the kernels. It explains the dark matter effect of galaxies to the extent that a numerical value of Milgrom’s acceleration constant can be assigned by theory. Non-polarized vacuum particles beyond the baryonic kernels compose the dark energy at the cosmological level. The result is an interpretation of gravity at the quantum level in terms of quantitatively established shares in baryonic matter, dark matter and dark energy, which correspond with the values of the Lambda-CDM model.","Milgrom’s acceleration constant; Bekenstein-Hawking entropy; gravitational dipole; dark matter","2023-05-23 08:04:24","/frontend/manuscript/4c7a58bbb30f1e8ffad8be5df991d410/download_pub",[2384],{"id":2385,"name":2386,"email":2387,"is_corresponding":6,"orcid_link":2388,"author_mark":266,"sp_link":2389},343321,"Engel Roza","engel.roza@onsbrabantnet.nl","https://orcid.org/0000-0002-4911-9948","https://sciprofiles.com/profile/210514",{"manuscript_id":2391,"manuscript_version":752,"hash_key":2392,"id":585,"version":752,"voted":47,"votes":1123,"article_title":2393,"article_abstract":2394,"article_keywords":2395,"top_subject_name":107,"subject_name":2365,"article_type_name":140,"published_at":2396,"download_url":2397,"rank":53,"authors":2398},"202109.0323","3938e8517708e3439f4895980b1fda79","The Morphology of the Active Galactic Nucleus and its Impact on Accretion Flows and Relativistic Jets","The G2 gas cloud motion data and the scarcity of observations on the event horizon-scale distances have challenged the comprehensiveness of the central supermassive black hole model. In addition, the Planck Legacy 2018 release has preferred a positively curved early Universe with a confidence level higher than 99%. This study investigates the impact of the background curvature and its evolution over the conformal time on the formation and morphological evolution of central compact objects and the consequent effect on their host galaxies. The formation of a galaxy from the collapse of a supermassive gas cloud in the early Universe is modeled based on interaction field equations as a 4D relativistic cloud-world that flows and spins through a 4D conformal bulk of a primordial positive curvature considering the preference of the Planck release. Owing to the curved background, this scenario of galaxy formation reveals that the core of the galaxy undergoes a forced vortex formation with a central event horizon leading to opposite vortices (traversable wormholes) that spatially shrink while evolving in the conformal time. It indicates that the galaxy and its core are formed in the same process whereas the surrounding gas clouds form the spiral arms due to the frame-dragging induced by the fast-rotating core. It demonstrates that the accretion flow onto the central supermassive compact object only occurs at the central event horizon of the two opposite vortices while their other ends eject the relativistic jets. This can elucidate the relativistic jet formation and explain the G2 gas cloud motion if its orbit is around one of the vortices but at a distance from the central event horizon. The gravitational potential of the early curved bulk could contribute to galaxy formation while the present spatial flatness deprives the potential of bulk which could lead to galaxy quenching. The formation of a galaxy and its core simultaneously could explain the growth of the supermassive compact galaxy core to a mass of ~10\u003Csup>9\u003C/sup> \u003Cem>M\u003C/em>\u003Csub>⊙\u003C/sub> at just 6% of the current Universe age. ","Relativistic Jets; Conformal Space-time Background.","2023-01-12 13:50:25","/frontend/manuscript/3938e8517708e3439f4895980b1fda79/download_pub",[2399],{"id":2400,"name":2401,"email":2402,"is_corresponding":6,"orcid_link":2403,"author_mark":266,"sp_link":2404},310469,"Mohammed Al-Fadhli","malfadhli@lincoln.ac.uk","https://orcid.org/0000-0003-4267-6087","https://sciprofiles.com/profile/1072817",{"manuscript_id":2406,"manuscript_version":7,"hash_key":2407,"id":5,"version":7,"voted":47,"votes":270,"article_title":2408,"article_abstract":2409,"article_keywords":2410,"top_subject_name":107,"subject_name":2318,"article_type_name":140,"published_at":2411,"download_url":2412,"rank":53,"authors":2413},"202305.2150","5ae86ee6439c955216037af93e2987df","Metallic and Insulating Phases in Two-Dimensional Strongly-Coupled Field Theories With a Gravitational Dua","We consider a specific holographic model in the limit where the gauge field does not couple to the rest of of the holographic fields (gravity and scalar sector) and investigate a phase of matter at zero charge density, a realistic feature that may have implications for disordered strange metals. We then pick a specific form of the gauge coupling $Z(\\alpha)$ with a certain disorder realization and argue that this provides a hard-gapped insulator with exponentially-suppressed conductivity by holographic methods. The limit is non-trivial: as there is backreaction at zero density amount, surviving in the coupled case.","Holography","2023-05-30 13:17:48","/frontend/manuscript/5ae86ee6439c955216037af93e2987df/download_pub",[2414],{"id":2415,"name":2416,"email":2417,"is_corresponding":6,"orcid_link":2418,"author_mark":266,"sp_link":2419},347487,"Matthew Stephenson","matthewjstephenson@icloud.com","https://orcid.org/0000-0001-7171-9248","https://sciprofiles.com/profile/2975054",{"manuscript_id":2421,"manuscript_version":1123,"hash_key":2422,"id":2423,"version":1123,"voted":47,"votes":270,"article_title":2424,"article_abstract":2425,"article_keywords":2426,"top_subject_name":107,"subject_name":2365,"article_type_name":140,"published_at":2427,"download_url":2428,"rank":53,"authors":2429},"202105.0197","a00b1b77b1f9e035402196230e4bee8d",8,"Space Theory","The author introduces a novel theoretical framework that suggests matter and energy are both converted from curved space. In Space Theory, gravitation is generated by the flow of space, instead of being transmitted by the graviton as in String Theory. This theory also suggests that Newton's gravitational constant, denoted as G, may not be truly constant but could vary over time. The equivalent equation of space is S=Ec\u003Csup>2\u003C/sup>=mc\u003Csup>4\u003C/sup>, and the gravitation of hollow sphere space is S\u003Csub>μν\u003C/sub>=4πGm=(4/3)π((r+a)\u003Csup>3\u003C/sup>-r\u003Csup>3\u003C/sup>). The Space Theory also predicts that the surface gravitational acceleration of the neutron star Crab Pulsar (PSR B0531+21) is approximately 8.21924883×10\u003Csup>6\u003C/sup> m/s\u003Csup>2\u003C/sup>.","space; gravitation","2023-09-27 03:06:32","/frontend/manuscript/a00b1b77b1f9e035402196230e4bee8d/download_pub",[2430],{"id":2431,"name":2432,"email":2433,"is_corresponding":6,"orcid_link":2434,"author_mark":266,"sp_link":2435},403086,"S. Chen","chen@rheast.com","https://orcid.org/0000-0002-1988-6329","https://sciprofiles.com/profile/1620826",{"manuscript_id":2437,"manuscript_version":752,"hash_key":2438,"id":132,"version":752,"voted":47,"votes":280,"article_title":2439,"article_abstract":2440,"article_keywords":2441,"top_subject_name":107,"subject_name":2349,"article_type_name":140,"published_at":2442,"download_url":2443,"rank":53,"authors":2444},"202301.0570","ed5549f3618394333e67266c0e522c0b","Non-Local EPR Correlations using Quaternion Spin","A statistical simulation is presented which reproduces the correlation obtained from EPR coincidence experiments without non-local connectivity. We suggest that spin carries two complementary properties. In addition to the spin polarization, we identify spin coherence as an attribute which is anti-symmetric and generates the helicity. This spin has structure formed from two orthogonal magnetic moments of spin $1/2$ each. These couple in free flight to form a spin 1, a boson. Upon encountering a filter, the spin 1 decouples into its two independent spins axes of $\\frac{1}{2}$, with one aligning with the filter and the other randomizing. The process of decoupling from a free-flight boson to a measured fermion is responsible for the quantum correlation which results in the observe violation of Bell's Inequalities. The polarized states give a CHSH value of 2 while the resonance spin give a CHSH value of 3, more than from an entangled state which is $2\\sqrt{2}$. Coherence can only be formulated by the existence of a bivector which gives a spin the same geometric structure as a photon. The only variable in this work is the angle that orients a spin on the Bloch sphere, first identified in the 1920's. The new features introduced here result from changing the spin symmetry from SU(2) to the quaternion group, $Q_8$. This introduces a bivector into the Dirac equation giving an element of reality which is anti-Hermitian. The calculations use standard spin algebra, and properties of quaternions.","Foundations of physics; Dirac equation; Spin; Quantum Theory; non-locality; helicity","2023-10-18 10:08:48","/frontend/manuscript/ed5549f3618394333e67266c0e522c0b/download_pub",[2445],{"id":2446,"name":2447,"email":2448,"is_corresponding":6,"orcid_link":2449,"author_mark":266,"sp_link":2450},413242,"Bryan Sanctuary","bryan.sanctuary@mcgill.ca","https://orcid.org/0000-0003-0910-2516","https://sciprofiles.com/profile/2719726",{"manuscript_id":2452,"manuscript_version":1905,"hash_key":2453,"id":752,"version":1905,"voted":47,"votes":41,"article_title":2454,"article_abstract":2455,"article_keywords":2456,"top_subject_name":107,"subject_name":2457,"article_type_name":140,"published_at":2458,"download_url":2459,"rank":53,"authors":2460},"202212.0045","296f764d00bd90d5e87bd88a97cac692","The Imaginary Universe","Maxwell's equations in vacuum provide the negative speed of light -\u003Cem>c\u003C/em>, which leads to imaginary Planck units. However, the second, negative fine-structure constant $\\alpha_2^{-1} \\approx -140.178$, present in the Fresnel coefficients for the normal incidence of electromagnetic radiation on monolayer graphene, establishes the different, negative speed of light in vacuum $c_2 \\approx -3.06 \\times 10^8~\\text{[m/s]}$, which introduces imaginary Planck units different in magnitude from those parametrized with $c$. Furthermore, algebraic relations between the fine-structure constant hint that the fine-structure constant does not vary over time. It follows that electric charges are the same in real and imaginary dimensions. We model neutron stars and white dwarfs, emitting perfect black-body radiation, as \\textit{objects} having energy exceeding their mass-energy equivalence ratios. We define complex energies in terms of real and imaginary natural units. Their imaginary parts, inaccessible for direct observation, store the excess of these energies. It is conjectured that the maximum atomic number $Z=238$. A black-body \\textit{object} is in the equilibrium of complex energies if its radius $R_\\text{eq} \\approx 1.3833~R_{\\text{BH}}$, which is close to the photon sphere radius $R_{\\text{ps}}=1.5~R_{\\text{BH}}$, and marginally greater than a locally negative energy density bound of $4/3~R_{\\text{BH}}$. The complex force between real masses and imaginary charges leads to the black-body object's surface gravity and generalized Hawking radiation temperature, which includes its charge. Furthermore, this force agrees with the physical parameters of the hydrogen atom. The proposed model takes into account the value(s) of the fine-structure constant(s), which is/are otherwise neglected in general relativity, and explains the registered (GWOSC) high masses of neutron stars' mergers and the associated fast radio bursts (CHIME) without resorting to any hypothetical types of exotic stellar \\textit{objects}.","emergent dimensionality; imaginary dimensions; natural units; fine-structure constant; black holes; neutron stars; white dwarfs; patternless binary messages; complex energy; complex force; Hawking radiation; extended periodic table; general relativity; photon sphere; entropic gravity; gravitational observations; holographic principle; mathematical physics","Mathematical Physics","2023-10-20 04:33:33","/frontend/manuscript/296f764d00bd90d5e87bd88a97cac692/download_pub",[2461],{"id":2462,"name":2463,"email":2464,"is_corresponding":6,"orcid_link":2465,"author_mark":266,"sp_link":2466},414411,"Szymon Łukaszyk","szymon@patent.pl","https://orcid.org/0000-0001-6644-2467","https://sciprofiles.com/profile/442327",{"category":2468,"manuscripts":2469},"Medicine and Pharmacology & Public Health and Healthcare",[2470,2504,2559,2636,2697,2728,2786,2846,2883,2914],{"manuscript_id":2471,"manuscript_version":7,"hash_key":2472,"id":2473,"version":7,"voted":47,"votes":2474,"article_title":2475,"article_abstract":2476,"article_keywords":2477,"top_subject_name":100,"subject_name":2478,"article_type_name":314,"published_at":2479,"download_url":2480,"rank":7,"authors":2481},"202307.1198","43929cf47f00130fa3fe56f3e76c0b1b",39,2086,"Autopsy Proven Fatal COVID-19 Vaccine-Induced Myocarditis","\u003Cstrong>Background:\u003C/strong> COVID-19 vaccines have been linked to myocarditis which in some circumstances can be fatal. This systematic review aims to investigate potential causal links between COVID-19 vaccines and death from myocarditis using post-mortem analysis. \u003Cstrong>Methods:\u003C/strong> We performed a systematic review of all published autopsy reports involving COVID-19 vaccination-related myocarditis through July 3\u003Csup>rd\u003C/sup>, 2023. All autopsy studies that include COVID-19 vaccine-induced myocarditis as a possible cause of death were included, without imposing any additional restrictions. Causality in each case was determined by three independent reviewers with cardiac pathology experience and expertise. \u003Cstrong>Results: \u003C/strong>We initially identified 1,691 studies and, after screening for our inclusion criteria, included 14 papers that contained 28 autopsy cases. The cardiovascular system was the only organ system affected in 26 cases. In 2 cases, myocarditis was characterized as a consequence from multisystem inflammatory syndrome (MIS). The mean and median number of days from last COVID-19 vaccination until death was 6.2 and 3 days, respectively. Most of the deaths occurred within a week from the last injection. We established that all 28 deaths were causally linked to COVID-19 vaccination by independent adjudication. \u003Cstrong>Conclusions:\u003C/strong> The temporal relationship, internal and external consistency seen among cases in this review with known COVID-19 vaccine-induced myocarditis, its pathobiological mechanisms and related excess death, complemented with autopsy confirmation, independent adjudication, and application of the Bradford Hill criteria to the overall epidemiology of vaccine myocarditis, suggests there is a high likelihood of a causal link between COVID-19 vaccines and death from suspected myocarditis in cases where sudden, unexpected death has occurred in a vaccinated person. Urgent investigation is required for the purpose of risk stratification and mitigation in order to reduce the population occurrence of fatal COVID-19 vaccine-induced myocarditis.","myocarditis; sudden death; chest pain; autopsy; necropsy; COVID-19; COVID-19 vaccines; mRNA; SARS-CoV-2 vaccination; death; excess mortality; spike protein; organ system","Cardiac and Cardiovascular Systems","2023-07-18 09:34:51","/frontend/manuscript/43929cf47f00130fa3fe56f3e76c0b1b/download_pub",[2482,2488,2493,2498],{"id":2483,"name":2484,"email":2485,"is_corresponding":6,"orcid_link":2486,"author_mark":266,"sp_link":2487},371229,"Nicolas Hulscher","nichulscher@gmail.com","https://orcid.org/0009-0008-0677-7386","https://sciprofiles.com/profile/3058151",{"id":2489,"name":2490,"email":2491,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2492},371230,"Roger Hodkinson","roger@hodkinson.ca","https://sciprofiles.com/profile/author/RUQwa0h4VnBPRWo2ZVdXNGZIa0VHeURDOEt3eXFGN2dOU3plQ2tvQ0JuYz0=",{"id":2494,"name":2495,"email":2496,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2497},371231,"William Makis","makisw79@yahoo.com","https://sciprofiles.com/profile/author/UUZpUWtrTHhiV3ZKcEg3NVMvSW1DNWl5MFRCelV5Y1FnbnpxSnBMYmIzST0=",{"id":2499,"name":2500,"email":2501,"is_corresponding":47,"orcid_link":2502,"author_mark":148,"sp_link":2503},371233,"Peter McCullough","peteramccullough@gmail.com","https://orcid.org/0000-0002-0997-6355","https://sciprofiles.com/profile/2383785",{"manuscript_id":2505,"manuscript_version":270,"hash_key":2506,"id":2507,"version":270,"voted":47,"votes":2508,"article_title":2509,"article_abstract":2510,"article_keywords":2511,"top_subject_name":100,"subject_name":2512,"article_type_name":140,"published_at":2513,"download_url":2514,"rank":280,"authors":2515},"202108.0327","7f6b60d1fa894f970c4e67d12e6bbc35",34,196,"Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens against E2F1-Driven Melanoma Progression","Skin melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream prometastatic gene regulatory networks (GRNs). Appropriate therapeutic manipulation of the E2F1-governed GRNs holds the potential to prevent metastasis however, these networks entail complex feedback and feedforward regulatory motifs among various regulatory layers, which make it difficult to identify druggable components. To this end, computational approaches such as mathematical modeling and virtual screening are important tools to unveil the dynamics of these signaling networks and identify critical components that could be further explored as therapeutic targets. Herein, we integrated a well-established E2F1-mediated epithelial-mesenchymal transition (EMT) map with transcriptomics data from E2F1-expressing melanoma cells to reconstruct a core regulatory network underlying aggressive melanoma. Using logic-based in silico perturbation experiments of a core regulatory network, we identified that simultaneous perturbation of Protein kinase B (AKT1) and oncoprotein murine double minute 2 (MDM2) drastically reduces EMT in melanoma. Using the structures of the two protein signatures, virtual screening strategies were performed with the FDA-approved drug library. Thus, by combining drug repurposing and computer-aided drug design techniques, followed by molecular dynamics simulation analysis identified two potent drugs (Cialis and Finasteride) that can efficiently inhibit AKT1 and MDM2 protein signatures respectively, and with better therapeutic properties. We proposed that these two drugs could be considered for the development of therapeutic strategies for the management of aggressive melanoma.","Melanoma; Core regulatory network; in silico perturbationSystems pharmacology; Boolean model; Small molecule inhibitors; Virtual screening; ADME; E2F1","Oncology and Oncogenics","2023-06-12 10:22:29","/frontend/manuscript/7f6b60d1fa894f970c4e67d12e6bbc35/download_pub",[2516,2521,2526,2531,2537,2543,2548,2553],{"id":2517,"name":2518,"email":2519,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2520},353087,"Nivedita Singh","nivedita.singh@ucl.ac.uk","https://sciprofiles.com/profile/author/NjFtOEZ2YjdzUFBZbTllbXRoaW1NS3dCam5WOERtQTNFeEQzUExBZDIvYz0=",{"id":2522,"name":2523,"email":2524,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2525},353088,"Faiz M. Khan","faiz.khan3@uni-rostock.de","https://sciprofiles.com/profile/1972789",{"id":2527,"name":2528,"email":2529,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2530},353089,"Lakshmi Bala","lakshmibala@bbdu.ac.in","https://sciprofiles.com/profile/author/ZnJxaFF5YmZtdTg4UlBITnJDYVJvWHd6bzROU0hVVmN3cCtlQjk2WWQwdz0=",{"id":2532,"name":2533,"email":2534,"is_corresponding":47,"orcid_link":2535,"author_mark":148,"sp_link":2536},353090,"Julio Vera","julio.vera-gonzalez@uk-erlangen.de","https://orcid.org/0000-0002-3076-5122","https://sciprofiles.com/profile/900862",{"id":2538,"name":2539,"email":2540,"is_corresponding":47,"orcid_link":2541,"author_mark":148,"sp_link":2542},353091,"Olaf Wolkenhauer","olaf.wolkenhauer@uni-rostock.de","https://orcid.org/0000-0001-6105-2937","https://sciprofiles.com/profile/1022463",{"id":2544,"name":2545,"email":2546,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2547},353092,"Brigitte Pützer","brigitte.puetzer@med.uni-rostock.de","https://sciprofiles.com/profile/69063",{"id":2549,"name":2550,"email":2551,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2552},353093,"Stella Logotheti","styliani.logotheti@med.uni-rostock.de","https://sciprofiles.com/profile/980492",{"id":2554,"name":2555,"email":2556,"is_corresponding":6,"orcid_link":2557,"author_mark":266,"sp_link":2558},353094,"Shailendra K. Gupta","shailendra.gupta@uni-rostock.de","https://orcid.org/0000-0002-3470-3260","https://sciprofiles.com/profile/893999",{"manuscript_id":2560,"manuscript_version":7,"hash_key":2561,"id":2562,"version":7,"voted":47,"votes":2563,"article_title":2564,"article_abstract":2565,"article_keywords":2566,"top_subject_name":100,"subject_name":2478,"article_type_name":140,"published_at":2567,"download_url":2568,"rank":53,"authors":2569},"202309.0131","c25fa0c28e4d25b3981f8fb21d00ea26",40,111,"Forensic Analysis of the 38 Subject Deaths in the 6-Month Interim Report of the Pfizer/BioNTech BNT162b2 mRNA Vaccine Clinical Trial","The analysis reported here is unique in that it is the first study of the original data from the Pfizer/BioNTech BNT162b2 mRNA vaccine clinical trial (CA4591001) to be carried out by a group unaffiliated with the trial sponsor. Our study is a forensic analysis of the 38 trial subjects who died between July 27, 2020, the start of Phase 2/3 of the clinical trial, and March 13, 2021, the data end date of their 6-Month Interim Report. Phase 2/3 of the trial involved 44,060 subjects who were equally distributed into two groups and received Dose 1 of either the BNT162b2 mRNA vaccinated or the Placebo control (0.9% normal saline). At Week 20, when the BNT162b2 mRNA vaccine received Emergency Use Authorization from the U.S. FDA, subjects in the placebo arm were given the option to be BNT162b2 vaccinated. All but a few accepted. Surprisingly, a comparison of the number of subject deaths per week during the 33 Weeks of this study found no significant difference between the number of deaths in the vaccinated versus placebo arms for the first 20 weeks of the trial, the placebo-controlled portion of the trial. After Week 20, as subjects in the Placebo were unblinded and vaccinated, deaths among this still unvaccinated cohort of this group slowed and eventually plateaued. Deaths in the BNT162b2 vaccinated subjects continued at the same rate. Our analysis revealed inconsistencies between the subject data listed in the 6-Month Interim Report and publications authored by Pfizer/BioNTech trial site administrators. Most importantly, we found evidence of an over 3.7-fold increase in number of deaths due to cardiovascular events in BNT162b2 vaccinated subjects compared to Placebo controls. This significant adverse event signal was not reported by Pfizer/BioNTech. Potential sources of these data inconsistencies are identified.","BNT162b2 vaccine; Pfizer/BioNTech; cardiovascular events; COVID-19","2023-09-04 08:19:54","/frontend/manuscript/c25fa0c28e4d25b3981f8fb21d00ea26/download_pub",[2570,2576,2581,2586,2591,2596,2601,2606,2611,2616,2621,2626,2631],{"id":2571,"name":2572,"email":2573,"is_corresponding":6,"orcid_link":2574,"author_mark":266,"sp_link":2575},393144,"Corinne Michels","corinne.michels@icloud.com","https://orcid.org/0009-0003-3117-517X","https://sciprofiles.com/profile/3130652",{"id":2577,"name":2578,"email":2579,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2580},393145,"Daniel Perrier","dan-perrier@automation-software.com","https://sciprofiles.com/profile/author/ZnpqaVZYYi9tNFgycy83VnRwTE5XV2ZhMGRNNGx2SDU0NldtVEs0NW41bU9CV3JDMjNuamsxRWJCSmtnRENJKw==",{"id":2582,"name":2583,"email":2584,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2585},393146,"Jeyanthi Kunadhasan","jkunadhasan@proton.me","https://sciprofiles.com/profile/author/bzRpRDIyS3lUNFhDTnpBUWQzTDNRWnFjQTlKWWxaRUJjY3EzLzJmaUhodz0=",{"id":2587,"name":2588,"email":2589,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2590},393147,"Ed Clark","doeskyn@protonmail.com","https://sciprofiles.com/profile/author/TXdqdC9HMXYweWxQYXZzMDZiR29zd1lHZEdONk5nTFdSaGQwTkZ1Zzcvaz0=",{"id":2592,"name":2593,"email":2594,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2595},393148,"Joseph Gehrett","jogjr27@gmail.com","https://sciprofiles.com/profile/author/QlJYM2lhM3J3SEZGSEpwQkExNTB0YW0zSlN5amxHMHBMbW1vMTVKZWxMdz0=",{"id":2597,"name":2598,"email":2599,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2600},393149,"Barbara Gehrett","thebkg17@gmail.com","https://sciprofiles.com/profile/author/dUdCQWNEQ0FSRWQyOWZ5NUJQRFRFWkwyRzc5L0NiUjNPYzlYSXMyRjdSZz0=",{"id":2602,"name":2603,"email":2604,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2605},393150,"Kim Kwiatek","kdkmd1@protonmail.com","https://sciprofiles.com/profile/author/enozRlZDcFhzcTJkTW1aVFpPd0tnd2Y0UXRNYTcvOTdQMXpvaXFERkMzWT0=",{"id":2607,"name":2608,"email":2609,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2610},393151,"Sarah Adams","spohadams@protonmail.com","https://sciprofiles.com/profile/author/OFpJSXRJMnp5bFZlNXVWeC9EZ1IzTEZybU5SN2ZhZDNVN2pDQlA5SUZTQT0=",{"id":2612,"name":2613,"email":2614,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2615},393152,"Robert Chandler","cardinals71@gmail.com","https://sciprofiles.com/profile/author/V3FpS1YwQ0QyUWM4Qi81OWpqT2k0ZmtJNVdGdDVuRFdRRkwrTE5WUzhwND0=",{"id":2617,"name":2618,"email":2619,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2620},393153,"Leah Stagno","biotechbabe2010@hotmail.com","https://sciprofiles.com/profile/author/SWY3WkdRTDVzQ1g2QXEwa3NoTEhiYlpDbDM3ZHlIRWQ2Y01zWFB5UkNEZz0=",{"id":2622,"name":2623,"email":2624,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2625},393154,"Tony Damian","tonydamian@protonmail.com","https://sciprofiles.com/profile/3138039",{"id":2627,"name":2628,"email":2629,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2630},393155,"Erika Delph","emdelph70@proton.me","https://sciprofiles.com/profile/author/RlhzR0pLSzEwUHBoYXpwR0RBcExLQWdkT1lqN0lwY0pWQ1BNL0FHL0YvYz0=",{"id":2632,"name":2633,"email":2634,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2635},393156,"Chris Flowers","chrisflowers@mac.com","https://sciprofiles.com/profile/author/WnRSWjhMbXhZdEpTSjh6YUN1QXAzNlExa0tFODB0TFJtNmozUUtUUGhtST0=",{"manuscript_id":2637,"manuscript_version":7,"hash_key":2638,"id":1459,"version":7,"voted":47,"votes":475,"article_title":2639,"article_abstract":2640,"article_keywords":2641,"top_subject_name":100,"subject_name":2642,"article_type_name":140,"published_at":2643,"download_url":2644,"rank":53,"authors":2645},"202306.0617","9edc28298cf59bf4a069856a8c84532a","Neuroprotective and Disease Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer’s Disease","The introduction of anti-amyloid monoclonal antibodies against Alzheimer’s disease (AD) is of high importance. However, even though treated patients show very little amyloid pathology, there is only a modest effect on the rate of cognitive decline. Although this effect possibly can increase over time, there is still a need for alternative treatments that will improve the cognitive function in patients with AD. Therefore, the purpose of this study was to characterize the triazinetrione ACD856, a novel pan-Trk positive allosteric modulator, in multiple models to address its neuroprotective and potential disease modifying effects. The pharmacological effect of ACD856 was tested in recombinant cell lines, primary cortical neurons or animals. We demonstrate that ACD856 enhanced NGF-induced neurite outgrowth, increased the levels of the pre-synaptic protein SNAP25 in PC12 cells and increased the degree of phosphorylated TrkB in SH-SY5Y cells. In primary cortical neurons, ACD856 led to increased levels of phospho-ERK1/2, showed neuroprotective effect against amyloid-beta or energy-deprivation induced neurotoxicity, and increased the levels of brain derived neurotrophic factor (BDNF). Consequently, administration of ACD856 resulted in a significant increase of BDNF in the brains of 21-months old mice. Furthermore, repeated administration of ACD856 resulted in a sustained anti-depressant effect which lasted up to seven days, suggesting effects that go beyond merely symptomatic effects. In conclusion, the results confirm ACD856 as a cognitive enhancer, but more importantly, they provide substantial in vitro and in vivo evidence of neuroprotective and long-term effects that contribute to neurotrophic support and increased neuroplasticity. Presumably, the described effects of ACD856 may improve cognition, increase resilience, and promote neurorestorative processes, thereby leading to a healthier brain in patients with AD.","Brain-derived neurotrophic factor; nerve growth factor; Alzheimer’s disease; allosteric modulator; cognitive function; anti-depressant","Neuroscience and Neurology","2023-06-08 09:55:01","/frontend/manuscript/9edc28298cf59bf4a069856a8c84532a/download_pub",[2646,2651,2656,2661,2666,2671,2676,2681,2686,2691],{"id":2647,"name":2648,"email":2649,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2650},351915,"Cristina Parrado-Fernandez","cristina.parrado@alzceurpharma.com","https://sciprofiles.com/profile/author/bXBwZkdsKzVmQm4xT0pNWitOWXZ2c0tadlhuaWtocEkxS0pJVzlwRTJxVmszUXlCY3hjTVZydVBsSW8yTXJLeg==",{"id":2652,"name":2653,"email":2654,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2655},351916,"Sanja Juric","sanja.juric@alzecurepharma.com","https://sciprofiles.com/profile/author/b1hCUFY5cUVRbGh0YUEyL05hVUtVM0hCbjE0c0hLT2swdkl3dzFtbGg5VT0=",{"id":2657,"name":2658,"email":2659,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2660},351917,"Maria Backlund","maria.backlund@alzecurepharma.com","https://sciprofiles.com/profile/author/ZVpacW05SVp4dXRqNlNkV1JWRkQxSk12ZVYyU1k3ejIzSGdyM1pCZ1E5RzA0WVY1K0hmTDd3YXkyczRBWGFJUQ==",{"id":2662,"name":2663,"email":2664,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2665},351918,"Märta Dahlström","marta.dahlstrom@alzecurepharma.com","https://sciprofiles.com/profile/author/U1lXcUxaWSsrUzgwY09ueU41RmVOU0l2YzBuZDdiZUpwbXR2b1FJZVJiNWhUTjRsbm5tZE1yQ1RiRWR5L1JOOA==",{"id":2667,"name":2668,"email":2669,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2670},351919,"Nather Madjid","nather.madjid@alzecurepharma.com","https://sciprofiles.com/profile/author/U1FpZ04rWkxtcGtpZWVKS2NoWHhuNWpLQmpkK0V1YVRvN1Q3SXZJaWN5RGNTRTk4ZkdoRTdQUUpSMy9CL1VHeQ==",{"id":2672,"name":2673,"email":2674,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2675},351920,"Veronica Lidell","veronica.lidell@alzecurepharma.com","https://sciprofiles.com/profile/author/MnJHbXNGYUJSRjlYdEd6dE5IMnF1TVdQaHpRSVpEVDNId1ZvL3R4ZjBhQ3p3eE9hN0xrRncwdzBCTUttS25zUA==",{"id":2677,"name":2678,"email":2679,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2680},351921,"Azita Rasti","azita.rasti@alzecurepharma.com","https://sciprofiles.com/profile/author/UnRIK1VQSjVxQW04K1FkN29mczVpSkRwN1IzT2ZscGV1bkF2YWdPVG56Yz0=",{"id":2682,"name":2683,"email":2684,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2685},351922,"Johan Sandin","johan.sandin@alzecurepharma.com","https://sciprofiles.com/profile/author/U1hUTEEyS2tVaExjTFRieVJpQWlMcFpsdyswY25GTlZVVXFvOTJVTTYybz0=",{"id":2687,"name":2688,"email":2689,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2690},351923,"Gunnar Nordvall","gunnar.nordvall@alzecurepharma.com","https://sciprofiles.com/profile/author/VkovN0E0RmtCQlJIQXgybVZLbmZFZE52ZG1QZGQ0alRQR3djeVlpVWI3R1czWjZBUjdQSVNEWXFtMzNacGpLNA==",{"id":2692,"name":2693,"email":2694,"is_corresponding":6,"orcid_link":2695,"author_mark":266,"sp_link":2696},351924,"Pontus Forsell","pontus.forsell@alzecurepharma.com","https://orcid.org/0000-0002-8384-1547","https://sciprofiles.com/profile/1618976",{"manuscript_id":2698,"manuscript_version":7,"hash_key":2699,"id":2700,"version":7,"voted":47,"votes":957,"article_title":2701,"article_abstract":2702,"article_keywords":2703,"top_subject_name":100,"subject_name":2704,"article_type_name":2705,"published_at":2706,"download_url":2707,"rank":53,"authors":2708},"202303.0441","3317636ae62e134f2d77d8d16a248541",38,"IgG4 Antibodies Induced by mRNA Vaccines Generate Immune Tolerance to SARS-CoV-2’spike Protein by Suppressing the Immune System","Due to the health crisis caused by SARS-CoV-2, the creation of a new vaccine platform based on mRNA was implemented. Globally, around 13.32 billion COVID-19 vaccine doses of diverse platforms have been given, and up to this date, 69.7% of the total population received at least one injection of a COVID-19 vaccine. Although these vaccines prevent hospitalization and severe forms of the disease, increasing evidence has shown they do not produce sterilizing immunity, allowing people to suffer frequent re-infections. Recent research has also raised concerns that mRNA vaccines could induce immune tolerance, which, added to that caused by the virus itself, could complicate the clinical course of a COVID-19 infection. Furthermore, recent investigations have found high IgG4 levels in people who were administered two or more injections of mRNA vaccines. It has been suggested that an increase in IgG4 levels could have a protecting role by preventing immune over-activation, similar to that occurring during successful allergen-specific immunotherapy by inhibiting IgE-induced effects. Altogether, evidence suggests that the reported increase in the IgG4 levels detected after repeated vaccination with the mRNA vaccines is not a protective mechanism; rather, it may be a part of the immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses. IgG4-induced suppression of the immune system due to repeated vaccination can also cause autoimmune diseases, promotes cancer growth, and autoimmune myocarditis in susceptible individuals.","IgG4 antibodies; mRNA vaccines; immuno-tolerance; auto-immunity; SARS-CoV-2; COVID-19.","Pulmonary and Respiratory Medicine","Hypothesis","2023-03-27 03:56:26","/frontend/manuscript/3317636ae62e134f2d77d8d16a248541/download_pub",[2709,2715,2720,2722],{"id":2710,"name":2711,"email":2712,"is_corresponding":6,"orcid_link":2713,"author_mark":266,"sp_link":2714},322835,"Vladimir N. Uversky","vuversky@usf.edu","https://orcid.org/0000-0002-4037-5857","https://sciprofiles.com/profile/900545",{"id":2716,"name":2717,"email":2718,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2719},322836,"Elrashdy M. Redwan","lradwan@kau.edu.sa","https://sciprofiles.com/profile/371740",{"id":2721,"name":2495,"email":2496,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2497},322837,{"id":2723,"name":2724,"email":2725,"is_corresponding":6,"orcid_link":2726,"author_mark":266,"sp_link":2727},322838,"Alberto Rubio-Casillas","alberto110966@gmail.com","https://orcid.org/0000-0003-2978-5107","https://sciprofiles.com/profile/3647022",{"manuscript_id":2729,"manuscript_version":7,"hash_key":2730,"id":957,"version":7,"voted":47,"votes":985,"article_title":2731,"article_abstract":2732,"article_keywords":2733,"top_subject_name":100,"subject_name":2642,"article_type_name":2734,"published_at":2735,"download_url":2736,"rank":53,"authors":2737},"202304.0108","cd9ada570d71844f6204980c9ef86342","Towards a Biological Definition of Parkinson’s Disease","With the growing hope that disease-modifying treatments could target the molecular basis of neurodegenerative diseases even before the onset of symptoms, there is mounting pressure to define disease entities based on pathophysiology rather than on clinical syndromes. The Alzheimer’s disease research community has recently transitioned from diagnostic criteria based on an amnestic syndrome to a purely biomarker-based disease definition, relying on the demonstration of amyloid-beta pathology, tau pathology, and neurodegeneration. In contrast, current diagnostic criteria for Parkinson’s disease still rely on the presence of the well-described clinical syndrome of parkinsonism, with the addition of characteristic motor- and non-motor signs and symptoms. However, there is now unequivocal evidence that Parkinson’s disease starts years before the onset of parkinsonism. Furthermore, neuropathologically defined Lewy body disease is clinically heterogeneous, combining a range of motor, non-motor, dopaminergic and non-dopaminergic features. Finally, clinically defined Parkinson’s disease has diverse underlying etiologies most, but not all, associated with α-synuclein positive Lewy pathology. In light of recent scientific advances, we propose a biologically based definition for the diagnosis of Parkinson's disease, initially to be used for research purposes. The criteria use a three-component ‘G-S-N’ system. The first is documentation of defined gene variants (‘G’), which cause or strongly predispose to PD as the most upstream component. The second is α-synuclein pathology (‘S’), currently defined as pathological α-synuclein deposition in tissue or positive α-synuclein seeding assays. The third is evidence of underlying neurodegeneration (‘N’), currently defined by specific neuroimaging procedures. The associated clinical syndrome (‘C’) is defined by a single high-specificity feature or multiple lower-specificity features. Initiating this transition will enable the field to fuel both basic and clinical research and move closer to the precision medicine required to develop clinically meaningful disease-modifying therapies. We acknowledge current limitations, ethical implications, and the need for prospective validation of this approach.","Parkinson’s disease; genetics; α-synuclein; neurodegeneration; clinical manifestation; diagnosis","Concept Paper","2023-04-07 03:54:11","/frontend/manuscript/cd9ada570d71844f6204980c9ef86342/download_pub",[2738,2744,2749,2754,2760,2766,2771,2776,2781],{"id":2739,"name":2740,"email":2741,"is_corresponding":6,"orcid_link":2742,"author_mark":266,"sp_link":2743},324593,"Günter U. Höglinger","hoeglinger.guenter@mh-hannover.de","https://orcid.org/0000-0001-7587-6187","https://sciprofiles.com/profile/1591161",{"id":2745,"name":2746,"email":2747,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2748},324594,"Charles H. Adler","cadler@mayo.edu","https://sciprofiles.com/profile/author/L2RYbVp3b1RaOWJjbS9PQ01UdHlIZz09",{"id":2750,"name":2751,"email":2752,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2753},324595,"Daniela Berg","daniela.berg@uksh.de","https://sciprofiles.com/profile/author/ZzNvaDBhZTViS0hyQ2Q1SEVDb296S2xiQWJ6VlJUV2NFaUlaalQzVFh5UT0=",{"id":2755,"name":2756,"email":2757,"is_corresponding":47,"orcid_link":2758,"author_mark":148,"sp_link":2759},324596,"Christine Klein","christine.klein@neuro.uni-luebeck.de","https://orcid.org/0000-0003-2102-3431","https://sciprofiles.com/profile/1477150",{"id":2761,"name":2762,"email":2763,"is_corresponding":47,"orcid_link":2764,"author_mark":148,"sp_link":2765},324597,"Tiago F. Outeiro","tiago.outeiro@med.uni-goettingen.de","https://orcid.org/0000-0003-1679-1727","https://sciprofiles.com/profile/1272894",{"id":2767,"name":2768,"email":2769,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2770},324598,"Werner Poewe","werner.poewe@i-med.ac.at","https://sciprofiles.com/profile/author/WlVHSjBmYXJncHFYUTd3UTRpd3pnb1E0QXFiU2owbDZ0L0ZHNThyazJoWT0=",{"id":2772,"name":2773,"email":2774,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2775},324599,"Ronald Postuma","ron.postuma@mcgill.ca","https://sciprofiles.com/profile/author/c1VBQVl5RllFZm5FUVovQUVyN3l3Sm12SmRwWUpwNy9sOHRTOU5hUTVRdz0=",{"id":2777,"name":2778,"email":2779,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2780},324600,"Jon Stoessl","jon.stoessl@ubc.ca","https://sciprofiles.com/profile/author/eFNrQzZLN0QvSDRHT1h4bkx6VXFXMHMyQXBTK2lLQzZZbFRtSE5EZWc0ND0=",{"id":2782,"name":2783,"email":2784,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2785},324601,"Anthony E. Lang","anthony.lang@uhnresearch.ca","https://sciprofiles.com/profile/author/bUVvenRqWjg5WCtXQnc0cHBLNEY1ZTRSWlROLzI0NUhoNXR6bHZSZjZjcz0=",{"manuscript_id":2787,"manuscript_version":7,"hash_key":2788,"id":1861,"version":7,"voted":47,"votes":1817,"article_title":2789,"article_abstract":2790,"article_keywords":2791,"top_subject_name":100,"subject_name":2792,"article_type_name":140,"published_at":2793,"download_url":2794,"rank":53,"authors":2795},"202310.0903","880c1fb8ac02393a23c944180f4fd459","Effects of Acute and Chronic Gabapentin Treatment on Cardiovascular Function of Rats","Gabapentin (GBP), a GABA analogue, is primarily used as an anticonvulsant to treat partial seizures and neuropathic pain. While a majority of the side effects are associated with the nervous system, emerging evidence suggests a high risk for heart diseases in the patients taking GBP. In the present study, we used a preclinical model of rats to investigate (1) the acute cardiovascular responses to GBP (bolus \u003Cem>i.v.\u003C/em> injection, 50 mg/kg) and (2) the effects of chronic GBP treatment (\u003Cem>i.p.\u003C/em> 100 mg/kg/day x 7 days) on cardiovascular function and the myocardial proteome. Under isoflurane-anesthesia, rat blood pressure (BP), heart rate (HR), and left ventricular (LV) hemodynamics were measured using Millar pressure transducers. The LV myocardium and brain cortex were analyzed by proteomics, bioinformatics, and western blot to explore the molecular mechanisms underlying GBP-induced cardiac dysfunction. In experiment (1), we found that \u003Cem>i.v.\u003C/em> GBP significantly decreased BP, HR, maximal LV pressure, and maximal and minimal dP/dt, whereas it increased IRP-AdP/dt, Tau, systolic, diastolic, and cycle durations (*\u003Cem>p \u003C/em>< 0.05 and **\u003Cem>p \u003C/em>< 0.01 \u003Cem>vs\u003C/em> baseline; n = 4/group). In experiment (2), we found that chronic GBP treatment resulted in hypotension, bradycardia, and LV systolic dysfunction, with no change in plasma norepinephrine. In the myocardium, we identified 109 differentially expressed proteins involved in calcium pathways, cholesterol metabolism, and galactose metabolism. Particularly, we found that calmodulin, a key protein of intracellular calcium signaling, was significantly upregulated by GBP in the heart but not in the brain. In summary, we found that acute and chronic GBP treatments suppressed cardiovascular function in rats, which is attributed to abnormal calcium signaling in cardiomyocytes. These data reveal a novel side effect of GBP independent of the nervous system, providing important translational evidence to suggest that GBP can evoke adverse cardiovascular events by depression of myocardial function. ","Gabapentin; Arterial Blood Pressure; Heart Rate; Left Ventricular Function; Proteomics; Bioinformatics; Calmodulin;","Anesthesiology and Pain Medicine","2023-10-13 12:41:55","/frontend/manuscript/880c1fb8ac02393a23c944180f4fd459/download_pub",[2796,2801,2806,2812,2817,2823,2828,2834,2840],{"id":2797,"name":2798,"email":2799,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2800},411453,"Ved Pendyala","vedpendyala27@gmail.com","https://sciprofiles.com/profile/3204761",{"id":2802,"name":2803,"email":2804,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2805},411454,"Sarah Pribil","spribil@unmc.edu","https://sciprofiles.com/profile/3271768",{"id":2807,"name":2808,"email":2809,"is_corresponding":47,"orcid_link":2810,"author_mark":148,"sp_link":2811},411455,"Vicki Schaal","vicki.schaal@unmc.edu","https://orcid.org/0000-0002-2868-389X","https://sciprofiles.com/profile/873029",{"id":2813,"name":2814,"email":2815,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2816},411456,"Kanika Sharma","kasharma@unmc.edu","https://sciprofiles.com/profile/3243573",{"id":2818,"name":2819,"email":2820,"is_corresponding":47,"orcid_link":2821,"author_mark":148,"sp_link":2822},411457,"Sankarasubramanian Jagadesan","s.jagadesan@unmc.edu","https://orcid.org/0000-0002-9936-6082","https://sciprofiles.com/profile/2705930",{"id":2824,"name":2825,"email":2826,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2827},411458,"Li Yu","lyu@unmc.edu","https://sciprofiles.com/profile/author/ekoyaUtSS2dYYTFaNUEvbTVoeGo2QT09",{"id":2829,"name":2830,"email":2831,"is_corresponding":47,"orcid_link":2832,"author_mark":148,"sp_link":2833},411459,"Vikas Kumar","vikas.kumar@unmc.edu","https://orcid.org/0000-0001-7513-6832","https://sciprofiles.com/profile/1205546",{"id":2835,"name":2836,"email":2837,"is_corresponding":47,"orcid_link":2838,"author_mark":148,"sp_link":2839},411460,"Chittibabu Guda","babu.guda@unmc.edu","https://orcid.org/0000-0002-5393-9316","https://sciprofiles.com/profile/835926",{"id":2841,"name":2842,"email":2843,"is_corresponding":6,"orcid_link":2844,"author_mark":266,"sp_link":2845},411461,"Lie Gao","lgao@unmc.edu","https://orcid.org/0000-0002-7880-7213","https://sciprofiles.com/profile/1806138",{"manuscript_id":2847,"manuscript_version":132,"hash_key":2848,"id":1406,"version":132,"voted":47,"votes":1123,"article_title":2849,"article_abstract":2850,"article_keywords":2851,"top_subject_name":100,"subject_name":2512,"article_type_name":140,"published_at":2852,"download_url":2853,"rank":53,"authors":2854},"202309.0906","0ecddb9fb487c89a227f209f1ac62191","Establishment of a Novel Cancer-Specific Anti-HER2 Monoclonal Antibody H2Mab-250/H2CasMab-2 for Breast Cancers","\u003Cspan>Overexpression of human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers is an important target for monoclonal antibody (mAb) therapy. A\u003C/span>\u003Cspan>ll therapeutic mAbs, including anti-HER2 mAbs, exhibit adverse effects probably due to the recognition of antigens expressed in normal cells. Therefore, tumor-selective or specific mAbs can be beneficial in reducing the adverse effects. \u003C/span>\u003Cspan>In this study, we established a novel cancer-specific anti-HER2 antibody, named \u003C/span>\u003Cspan>H\u003Csub>2\u003C/sub>Mab-250/H\u003Csub>2\u003C/sub>\u003C/span>\u003Cspan>CasMa\u003C/span>\u003Cspan>b-2 \u003C/span>\u003Cspan>(IgG\u003Csub>1\u003C/sub>, kappa). \u003C/span>\u003Cspan>H\u003Csub>2\u003C/sub>Mab-250\u003C/span>\u003Cspan> reacted with HER2-positive breast cancer BT-474 and SK-BR-3 cells. Importantly, \u003C/span>\u003Cspan>H\u003Csub>2\u003C/sub>Mab-250\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>did not\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>react with non-transformed normal epithelial cells (HaCaT and MCF 10A) and \u003C/span>\u003Cspan>immortalized normal epithelial cells\u003C/span>\u003Cspan> in flow cytometry. In contrast, most anti-HER2 mAbs including \u003C/span>\u003Cspan>H\u003Csub>2\u003C/sub>Mab-119 \u003C/span>\u003Cspan>(IgG\u003Csub>1\u003C/sub>, kappa)\u003C/span>\u003Cspan> reacted with both cancer and normal epithelial cells. Furthermore, \u003C/span>\u003Cspan>a core-fucose deleted IgG\u003Csub>2a\u003C/sub>-type H\u003Csub>2\u003C/sub>Mab-250 (\u003C/span>\u003Cspan>H\u003Csub>2\u003C/sub>Mab-250-mG\u003Csub>2a\u003C/sub>-f\u003C/span>\u003Cspan>) could trigger the \u003C/span>\u003Cspan>antibody-dependent cellular cytotoxicity\u003C/span>\u003Cspan> activity to BT-474, but not to HaCaT cells.\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>Furthermore\u003C/span>\u003Cspan>,\u003C/span>\u003Cspan> H\u003Csub>2\u003C/sub>Mab-250-mG\u003Csub>2a\u003C/sub>-f exhibited an \u003C/span>\u003Ci>\u003Cspan>in vivo \u003C/span>\u003C/i>\u003Cspan>antitumor effect against \u003C/span>\u003Cspan>BT-474 xenograft.\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>I\u003C/span>\u003Cspan>mmunohistochemical analysis\u003C/span>\u003Cspan> demonstrated that H\u003Csub>2\u003C/sub>Mab-250 possesses much higher reactivity to the HER2-positive breast cancer tissues compared to H\u003Csub>2\u003C/sub>Mab-119, and did not react with normal tissues, including heart, breast, stomach, lung, colon, kidney, and esophagus. The epitope mapping \u003C/span>\u003Cspan>demonstrated\u003C/span>\u003Cspan> \u003C/span>\u003Cspan>that\u003C/span>\u003Cspan> the Trp614 of HER2 domain IV mainly contributes to the recognition by H\u003Csub>2\u003C/sub>Mab-250. \u003C/span>\u003Cspan>H\u003Csub>2\u003C/sub>Mab-250 \u003C/span>\u003Cspan>could contribute to the development of chimeric antigen receptor-T or antibody-drug conjugates without adverse effects for breast cancer therapy.\u003C/span>\u003Cspan>\u003C/span>","HER2; cancer-specific monoclonal antibody; screening; epitope; flow cytometry","2023-12-28 02:42:29","/frontend/manuscript/0ecddb9fb487c89a227f209f1ac62191/download_pub",[2855,2860,2866,2872,2877],{"id":2856,"name":2857,"email":2858,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2859},444873,"Mika K Kaneko","k.mika@med.tohoku.ac.jp","https://sciprofiles.com/profile/author/R3VJMEVab3d0WnhTVmRsWk5GTkRSMnZnYy8zS0pTUEhabHFHZHlpcHhvRT0=",{"id":2861,"name":2862,"email":2863,"is_corresponding":6,"orcid_link":2864,"author_mark":266,"sp_link":2865},444874,"Hiroyuki Suzuki","hiroyuki.suzuki.b4@tohoku.ac.jp","https://orcid.org/0000-0003-2646-5132","https://sciprofiles.com/profile/2007555",{"id":2867,"name":2868,"email":2869,"is_corresponding":47,"orcid_link":2870,"author_mark":148,"sp_link":2871},444875,"Tomokazu Ohishi","ohishit@bikaken.or.jp","https://orcid.org/0000-0002-9039-4474","https://sciprofiles.com/profile/638451",{"id":2873,"name":2874,"email":2875,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2876},444876,"Tomohiro Tanaka","tomohiro.tanaka.b5@tohoku.ac.jp","https://sciprofiles.com/profile/2859532",{"id":2878,"name":2879,"email":2880,"is_corresponding":6,"orcid_link":2881,"author_mark":266,"sp_link":2882},444877,"Yukinari Kato","yukinari.kato.e6@tohoku.ac.jp","https://orcid.org/0000-0001-5385-8201","https://sciprofiles.com/profile/651400",{"manuscript_id":2884,"manuscript_version":7,"hash_key":2885,"id":2886,"version":7,"voted":47,"votes":1295,"article_title":2887,"article_abstract":2888,"article_keywords":2889,"top_subject_name":100,"subject_name":2642,"article_type_name":140,"published_at":2890,"download_url":2891,"rank":53,"authors":2892},"202309.2091","fbeb53d333dc3d8d9e80c1ef58073402",35,"Assessing Functional Capacity in ME/CFS: A Patient Informed Questionnaire","Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is an acquired disease with significant morbidity that affects both children and adults. Effective tools to assess functional capacity (FC) are severely lacking which has significant consequences for timely diagnosis, assessments for patient disability benefits and assessing the impact and effectiveness of interventions. In interventional research the inability to assess FC can result in an incomplete assessment of the potential effect of the intervention. Specifically of concern is that if an intervention is effective in reducing symptom load, patients may increase their activity level to reach a pre-intervention symptom load. Thus, if FC is not accurately assessed, beneficial treatment outcomes may be missed. To address this issue, using extensive, repeated patient feedback we have developed a new questionnaire, FUNCAP, to achieve optimal FC assessment in ME/CFS patients. The questionnaire covers eight domains and activity types: A. Personal hygiene / basic functions, B. Walking / movement, C. Being upright, D. Activities in the home, E. Communication, F. Activities outside the home, G. Reactions to light and sound, and H. Concentration. Through five rounds of anonymous web-based surveys and a further test - retest validation round, two versions of the questionnaire were developed; a longer version comprising 55 questions (FUNCAP55) to improve diagnostic and disability benefit/ insurance FC assessments and a shorter version (FUNCAP27) for interventional research and less extensive FC assessments. FUNCAP may also be useful in other conditions where fatigue and PEM is present, such as Long Covid.","ME/CFS; chronic fatigue syndrome; functional capacity; post exertional malaise; questionnaire; survey","2023-09-29 09:21:59","/frontend/manuscript/fbeb53d333dc3d8d9e80c1ef58073402/download_pub",[2893,2898,2903,2908],{"id":2894,"name":2895,"email":2896,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":2897},405381,"Kristian Sommerfelt","kristian.sommerfelt@uib.no","https://sciprofiles.com/profile/2731769",{"id":2899,"name":2900,"email":2901,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2902},405382,"Trude Schei","post@me-foreningen.no","https://sciprofiles.com/profile/author/MGtMQ2s2MXBCWC9IUnltWHR3TzJyV2prRXlkZytTWlNtbkZaQmsvTzljST0=",{"id":2904,"name":2905,"email":2906,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":2907},405383,"Katharine A Seton","katharine.seton@quadram.ac.uk","https://sciprofiles.com/profile/3182741",{"id":2909,"name":2910,"email":2911,"is_corresponding":47,"orcid_link":2912,"author_mark":148,"sp_link":2913},405384,"Simon R Carding","simon.carding@quadram.ac.uk","https://orcid.org/0000-0002-2383-9701","https://sciprofiles.com/profile/169658",{"manuscript_id":2915,"manuscript_version":7,"hash_key":2916,"id":2917,"version":7,"voted":47,"votes":132,"article_title":2918,"article_abstract":2919,"article_keywords":2920,"top_subject_name":100,"subject_name":100,"article_type_name":140,"published_at":2921,"download_url":2922,"rank":53,"authors":2923},"202306.1682","a43a1b6a2cb5a5a4fd4753173e9bba60",31,"An Amphipathic Cell-Penetrating Peptide-Aided Delivery of Cas9 RNP for Gene Editing and Correction","The CRISPR/Cas9 gene editing system has enormous potential in the treatment of multiple genetic disorders. To fully harness this potential, it is essential to deliver CRISPR-Cas9 components safely and effectively into the nuclei of target cells. In this study, we tested the amphipathic cell-penetrating peptide LAH5, previously used for DNA delivery, to intracellularly deliver spCas9: sgRNA ribonucleoprotein (RNP) and RNP/single-stranded homology-directed repair (HDR) template. We discovered that the LAH5 peptide effectively formed nanocomplexes with both RNP and RNP/HDR cargo, and that these nanocomplexes were taken up by cells effectively. Peptide/RNP nanocomplexes were characterized for size and charge, and nanocomplexation with RNP and RNP/HDR cargo was demonstrated via an electrophoretic mobility shift assay. Various ratios of peptide/RNP nanocomplexes were functionally screened on fluorescent reporter cell lines for gene editing and HDR-mediated gene correction. Additionally, targeted gene editing of the CCR5 gene was demonstrated in various cell lines. This LAH5-based delivery strategy paves the way for the development of therapeutic delivery systems for CRISPR/Cas-based genomic engineering.","CRISPR/Cas9; Cell-penetrating peptide (CPP); LAH5; RNP; HDR; delivery","2023-06-23 12:31:05","/frontend/manuscript/a43a1b6a2cb5a5a4fd4753173e9bba60/download_pub",[2924,2930,2936],{"id":2925,"name":2926,"email":2927,"is_corresponding":47,"orcid_link":2928,"author_mark":148,"sp_link":2929},358936,"Mert Öktem","m.oktem@uu.nl","https://orcid.org/0000-0002-1478-6089","https://sciprofiles.com/profile/2962951",{"id":2931,"name":2932,"email":2933,"is_corresponding":47,"orcid_link":2934,"author_mark":148,"sp_link":2935},358937,"Olivier G. De Jong","o.g.dejong@uu.nl","https://orcid.org/0000-0002-5952-9617","https://sciprofiles.com/profile/3041888",{"id":2937,"name":2938,"email":2939,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":2940},358938,"Enrico Mastrobattista","e.mastrobattista@uu.nl","https://sciprofiles.com/profile/611953",{"category":2942,"manuscripts":2943},"Social Sciences, Arts and Humanities & Business, Economics and Management",[2944,2962,2985,3111,3221,3238,3260,3305,3320,3341],{"manuscript_id":2945,"manuscript_version":7,"hash_key":2946,"id":2947,"version":7,"voted":47,"votes":2948,"article_title":2949,"article_abstract":2950,"article_keywords":2951,"top_subject_name":121,"subject_name":2952,"article_type_name":140,"published_at":2953,"download_url":2954,"rank":7,"authors":2955},"202312.0564","46cb355f0f6de2a15bb4f2680357e5a9",78,658,"Bridging Digital Competence and Sustainability: Unveiling the Synergistic Potential of Design and Maker Education","Purpose: This study investigates the implementation and impact of maker culture—viewed as a tool for developing green digital skills—in higher education institutions in Hong Kong. Maker culture, a collaborative educational approach, embraces students’ capacity for self-paced, autonomous learning and applies this knowledge to creative problem-solving and innovation, key aspects of sustainability education.\r\nMethods: An empirical study was conducted, focusing on the experiences of teachers in the higher education sector in Hong Kong. Eight individuals were interviewed to gain insights into their perceptions and experiences with maker education within sustainability contexts. The sample was limited to ensure cross-sectional comparability and direct weighting of teachers’ experiences within a singular, complementary educational setting.\r\nResults: The findings provide valuable insights into the benefits and challenges of integrating maker education into traditional educational systems to foster green digital skills. It became evident that adequate resources, effective teachers, and improved administrative systems play significant roles in the successful implementation of this approach.\r\nConclusion: Maker education, as a tool for developing green digital skills, offers a promising alternative to traditional performance-based studies. It has the potential to lead to a future of education that is creative, innovative, and student-directed, fostering sustainability competences. Therefore, despite the challenges, with the right support and resources, the integration of maker culture into educational systems could significantly transform teaching and learning processes, advancing sustainability education.","maker education; green digital skills; problem-solving; innovation; creativity; engagement; sustainable education","Education","2023-12-08 08:31:01","/frontend/manuscript/46cb355f0f6de2a15bb4f2680357e5a9/download_pub",[2956],{"id":2957,"name":2958,"email":2959,"is_corresponding":6,"orcid_link":2960,"author_mark":266,"sp_link":2961},435770,"Noble Po-kan Lo","noble.lo@cpce-polyu.edu.hk","https://orcid.org/0000-0001-7636-6146","https://sciprofiles.com/profile/2775620",{"manuscript_id":2963,"manuscript_version":7,"hash_key":2964,"id":79,"version":7,"voted":47,"votes":2965,"article_title":2966,"article_abstract":2967,"article_keywords":2968,"top_subject_name":66,"subject_name":2969,"article_type_name":140,"published_at":2970,"download_url":2971,"rank":280,"authors":2972},"202305.0523","460e6c8d1c4ae92d83fd84b016c63aee",81,"Lightning Network’s Evolution: Unraveling Its Present State and the Emergence of Disruptive Digital Business Models","The Lightning Network (LN), a second-layer protocol built on top of the Bitcoin blockchain, is an innovative digital payment solution that offers increased convenience, speed, and cost-effectiveness to consumers and businesses alike. However, there is limited literature available on the characteristics of this nascent technology, the depth and breadth of the various business LN-related applications as well as relevant adoption/implementation challenges. This study aims to contribute to the understanding of the LN’s characteristics, its potential in enhancing business operations and its applicability across different sectors, while taking into account adoption and implementation challenges. We apply a narrative review methodology using a semi-systematic approach to examine new and emerging business models empowered by the LN and its characteristics, topology, performance, privacy, and security. We analyze the data to identify key themes and trends in the literature, offering a critical analysis of the strengths and weaknesses of the existing literature. Based on the findings, we provide several clusters of fruitful areas for future research directions. The findings of this study will help businesses make more informed decisions about adopting and leveraging the LN to improve their operations and enhance customer experience.","Lightning Network; Business models; Narrative review","Business and Management","2023-05-08 10:54:36","/frontend/manuscript/460e6c8d1c4ae92d83fd84b016c63aee/download_pub",[2973,2979],{"id":2974,"name":2975,"email":2976,"is_corresponding":6,"orcid_link":2977,"author_mark":266,"sp_link":2978},336401,"Thomas Dasaklis","dasaklis@eap.gr","https://orcid.org/0000-0003-1240-4822","https://sciprofiles.com/profile/1180274",{"id":2980,"name":2981,"email":2982,"is_corresponding":47,"orcid_link":2983,"author_mark":148,"sp_link":2984},336402,"Vangelis Malamas","bagmalamas@unipi.gr","https://orcid.org/0000-0001-9238-6796","https://sciprofiles.com/profile/2619206",{"manuscript_id":2986,"manuscript_version":7,"hash_key":2987,"id":2988,"version":7,"voted":47,"votes":1219,"article_title":2989,"article_abstract":2990,"article_keywords":2991,"top_subject_name":121,"subject_name":2952,"article_type_name":140,"published_at":2992,"download_url":2993,"rank":53,"authors":2994},"202309.1541","152efad9506bcc9ce49a4fce6393b6d5",77,"Factors Influencing Attitudes of University Students towards ChatGPT and its Usage: A Multi-National Study Validating the TAME-ChatGPT Survey Instrument","Artificial intelligence (AI)-based models hold the potential to transform higher education if adopted properly and ethically. A prime example is ChatGPT with earlier studies indicating its widespread adoption in academia and by university students. The current study aimed to identify the factors influencing the attitude towards ChatGPT and its usage among university students in Arab countries. A previous survey instrument termed Technology Acceptance Model Edited to Assess ChatGPT Adoption (TAME-ChatGPT) was administered online using a convenience-based approach among the contacts of the authors. Confirmatory factor analysis (CFA) for the survey constructs was done using root mean square error of approximation (RMSEA), standardized root mean square residual (SRMR), comparative fit index (CFI), and Tucker-Lewis index (TLI). The final study sample comprised a total of 2240 participant divided as follows: Iraq (n=736, 32.9%), Kuwait (n=582, 26.0%), Egypt (n=417, 18.6%), Lebanon (n=263, 11.7%), and Jordan (n=242, 10.8%). A total of 1048 respondents heard of ChatGPT before the study (46.8%), of which 551 used ChatGPT (52.6%). The mean scores of TAME-ChatGPT constructs showed that the ease of ChatGPT use, positive attitude towards technology and social influence, higher perceived usefulness, the influence of behavioral/cognitive factors, low perceived risks and low anxiety were the determinants of positive attitude to ChatGPT and its use. For both the attitude and usage scales of TAME-ChatGPT, CFA collectively yielded satisfactory fit indices as indicated by low RMSEA and SRMR together with high CFI and TLI. Multivariate analysis showed that attitude to ChatGPT use was significantly influenced by country of residence, age, university type, and the latest grade point average of the students. The current study confirmed the validity of TAME-ChatGPT as a survey instrument to assess the possible determinants of ChatGPT use among university students in Arab countries. The study findings highlighted that successful adoption of ChatGPT in higher education could be dependent on perceived ease of use, usefulness, positive attitudes to technology, social influence, behavioral/cognitive factors, lower anxiety, and minimal perceived risks. The utility of ChatGPT in higher education requires policies that should be tailored for various settings, considering the differences observed in attitude towards ChatGPT among participating students in this study.","higher education; technology acceptance; generative pre-trained transformer; curriculum design; academia","2023-09-22 08:39:44","/frontend/manuscript/152efad9506bcc9ce49a4fce6393b6d5/download_pub",[2995,3001,3007,3013,3019,3025,3030,3035,3040,3045,3050,3056,3062,3067,3072,3078,3083,3088,3094,3099,3105],{"id":2996,"name":2997,"email":2998,"is_corresponding":47,"orcid_link":2999,"author_mark":148,"sp_link":3000},401919,"Maram Abdaljaleel","m.abdaljaleel@ju.edu.jo","https://orcid.org/0000-0002-9257-2596","https://sciprofiles.com/profile/2152665",{"id":3002,"name":3003,"email":3004,"is_corresponding":47,"orcid_link":3005,"author_mark":148,"sp_link":3006},401920,"Muna Barakat","m_barakat@asu.edu.jo","https://orcid.org/0000-0002-7966-1172","https://sciprofiles.com/profile/1211350",{"id":3008,"name":3009,"email":3010,"is_corresponding":47,"orcid_link":3011,"author_mark":148,"sp_link":3012},401921,"Mariam Alsanafi","mariam.alsanafi@ku.edu.kw","https://orcid.org/0000-0002-1366-3693","https://sciprofiles.com/profile/2399274",{"id":3014,"name":3015,"email":3016,"is_corresponding":47,"orcid_link":3017,"author_mark":148,"sp_link":3018},401922,"Nesreen A. Salim","n.salim@ju.edu.jo","https://orcid.org/0000-0002-5355-2269","https://sciprofiles.com/profile/2730323",{"id":3020,"name":3021,"email":3022,"is_corresponding":47,"orcid_link":3023,"author_mark":148,"sp_link":3024},401923,"Husam Abazid","h_abazid@asu.edu.jo","https://orcid.org/0000-0002-4333-9712","https://sciprofiles.com/profile/3171869",{"id":3026,"name":3027,"email":3028,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3029},401924,"Diana Malaeb","dr.diana@gmu.ac.ae","https://sciprofiles.com/profile/2109714",{"id":3031,"name":3032,"email":3033,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3034},401925,"Ali Haider Mohammed","alihaider.mohammed@monash.edu","https://sciprofiles.com/profile/2366968",{"id":3036,"name":3037,"email":3038,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3039},401926,"Bassam Abdul Rasool Hassan","bassamsunny@yahoo.com","https://sciprofiles.com/profile/author/Rm9uL090WkEwZUZQMlF2MXlRQk9xNW1JUkgydmtuMkk0VGxNeDBlVXp2ST0=",{"id":3041,"name":3042,"email":3043,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3044},401927,"Abdulrasool M. Wayyes","wayyesr@hotmail.com","https://sciprofiles.com/profile/author/M0svVzlZNW9tekt6Q3JmcXkrbDJMR2xaN1AwVzU1WjBvVGtuV29TbzdtWT0=",{"id":3046,"name":3047,"email":3048,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3049},401928,"Sinan Subhi Farhan","sinansubhi@gmail.com","https://sciprofiles.com/profile/author/dll3eVdxTW9TZHR4Rm1WaGF2SkM2bktqd29OTzZOVlR2R3BtT2lKbmlKVT0=",{"id":3051,"name":3052,"email":3053,"is_corresponding":47,"orcid_link":3054,"author_mark":148,"sp_link":3055},401929,"Sami El Khatib","sami.khatib@liu.edu.lb","https://orcid.org/0000-0003-3611-3288","https://sciprofiles.com/profile/799394",{"id":3057,"name":3058,"email":3059,"is_corresponding":47,"orcid_link":3060,"author_mark":148,"sp_link":3061},401930,"Mohamad Rahal","mohamad.rahal@liu.edu.lb","https://orcid.org/0000-0002-9707-6217","https://sciprofiles.com/profile/1372656",{"id":3063,"name":3064,"email":3065,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3066},401931,"Ali Sahban","aly0201800@ju.edu.jo","https://sciprofiles.com/profile/author/V0FpeEJPaDZIQWZoL0tpR0N4N1luYXFWMWhYM3oxVDlkQ0RmOXJMRHFiRT0=",{"id":3068,"name":3069,"email":3070,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3071},401932,"Doaa H. Abdelaziz","doaa.yousef@fue.edu.eg","https://sciprofiles.com/profile/author/YXhHenB6eDRFdW5NUXA5YkpEaWRRcG9XZGdGcnB1TW52TDk4RkxRbnpQUT0=",{"id":3073,"name":3074,"email":3075,"is_corresponding":47,"orcid_link":3076,"author_mark":148,"sp_link":3077},401933,"Noha O. Mansour","nohamansaur@mans.edu.eg","https://orcid.org/0000-0002-4448-994X","https://sciprofiles.com/profile/2112250",{"id":3079,"name":3080,"email":3081,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3082},401934,"Reem AlZayer","r.alzayer@machs.edu.sa","https://sciprofiles.com/profile/author/MUJ0SER4UUx6b2ZWS2NjczZCc2FvaHMwNTZvb1N5dWRDMDRhMjZkZklEdz0=",{"id":3084,"name":3085,"email":3086,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3087},401935,"Roaa Khalil","raa8220792@ju.edu.jo","https://sciprofiles.com/profile/author/TG5od2VyUFh3TGZ2TTVxalJHVkdCUitsYTNqR1paWWJpTFNteXR4WU5mND0=",{"id":3089,"name":3090,"email":3091,"is_corresponding":47,"orcid_link":3092,"author_mark":148,"sp_link":3093},401936,"Feten Fekih-Romdhane","feten.fekih@gmail.com","https://orcid.org/0000-0002-2569-8017","https://sciprofiles.com/profile/2028428",{"id":3095,"name":3096,"email":3097,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3098},401937,"Rabih Hallit","hallitrabih@hotmail.com","https://sciprofiles.com/profile/756261",{"id":3100,"name":3101,"email":3102,"is_corresponding":47,"orcid_link":3103,"author_mark":148,"sp_link":3104},401938,"Souheil Hallit","souheilhallit@hotmail.com","https://orcid.org/0000-0001-6918-5689","https://sciprofiles.com/profile/207699",{"id":3106,"name":3107,"email":3108,"is_corresponding":6,"orcid_link":3109,"author_mark":266,"sp_link":3110},401939,"Malik Sallam","malik.sallam@ju.edu.jo","https://orcid.org/0000-0002-0165-9670","https://sciprofiles.com/profile/663766",{"manuscript_id":3112,"manuscript_version":132,"hash_key":3113,"id":3114,"version":132,"voted":47,"votes":2219,"article_title":3115,"article_abstract":3116,"article_keywords":3117,"top_subject_name":121,"subject_name":3118,"article_type_name":140,"published_at":3119,"download_url":3120,"rank":53,"authors":3121},"201908.0208","04cd8030ad968dd44028a5154a8bd790",72,"Optimizing Methodology of Sleep and Memory Research in Humans","Understanding the complex relationship between sleep and memory is a major challenge in neuroscience. Many studies on memory consolidation in humans suggest that sleep triggers offline memory processes, resulting in less forgetting of declarative memory and performance stabilization in non-declarative memory. However, issues related to non-optimal experimental designs, task characteristics and measurements, and inappropriate data analysis practices can significantly affect the interpretation of the effect of sleep on memory. In this article, we discuss these issues and suggest constructive solutions to address them. We believe that implementing these solutions in future sleep and memory research will significantly advance this field by improving the understanding of the specific role of sleep in memory consolidation. ","sleep; memory; consolidation; napping; fatigue","Cognitive Science","2023-06-26 10:56:59","/frontend/manuscript/04cd8030ad968dd44028a5154a8bd790/download_pub",[3122,3128,3133,3138,3143,3148,3153,3158,3163,3168,3174,3179,3185,3190,3195,3200,3206,3211,3216],{"id":3123,"name":3124,"email":3125,"is_corresponding":6,"orcid_link":3126,"author_mark":266,"sp_link":3127},359951,"Dezso Nemeth","dezso.nemeth@univ-lyon1.fr","https://orcid.org/0000-0002-9629-5856","https://sciprofiles.com/profile/807824",{"id":3129,"name":3130,"email":3131,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3132},359952,"Emilie Gerbier","emilie.gerbier@univ-cotedazur.fr","https://sciprofiles.com/profile/2713425",{"id":3134,"name":3135,"email":3136,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3137},359953,"Jan Born","jan.born@uni-tuebingen.de","https://sciprofiles.com/profile/author/MDVvRmx1KzJaSmZLRGNiZVd0R3RBaXNEQUpGamtuckF2YWR5SEhHVmpwMD0=",{"id":3139,"name":3140,"email":3141,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3142},359954,"Timothy Rickard","trickard@ucsd.edu","https://sciprofiles.com/profile/author/YnNrQ2l6Rnd5UkJvSFcxYjJmWFJYWHpkNUIzREdnVXczYkxEdzBiUzUzUT0=",{"id":3144,"name":3145,"email":3146,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3147},359955,"Susanne Diekelman","susanne.diekelmann@uni-tuebingen.de","https://sciprofiles.com/profile/author/RXRZdGdHd2I3NnA3dWJncXE5UUVJYWEwU0tDOEtxcDhjZVBRNkhtV3FvU0g2MUp6MFVFYVJDRHZOR1NrQ0d3dg==",{"id":3149,"name":3150,"email":3151,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3152},359956,"Stuart Fogel","sfogel@uottawa.ca","https://sciprofiles.com/profile/author/L0FaTHJ4bThDaUo5S0F5SkJPMEw0cE5UeW1KcUY0T3NHZWovYlZmSkV2cz0=",{"id":3154,"name":3155,"email":3156,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3157},359957,"Lisa Genzel","l.genzel@donders.ru.nl","https://sciprofiles.com/profile/author/ajVsMWZHZTAvRm1uNE1oODcxWUdmVDl1RFB2VnRFYUQweDlQSkh1Z0ZxMD0=",{"id":3159,"name":3160,"email":3161,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3162},359958,"Alexander Prehn-Kristensen","a.prehn@zip-kiel.de","https://sciprofiles.com/profile/author/aXU0QlEzRW16V0J2amdPZUl4UGFjUk00em5GVGUyNGdLS05jTGQ5NjRWQT0=",{"id":3164,"name":3165,"email":3166,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3167},359959,"Jessica Payne","jpayne7@nd.edu","https://sciprofiles.com/profile/author/VE1zNmZOQTBFWFFzNWxLSCtpb3M3QT09",{"id":3169,"name":3170,"email":3171,"is_corresponding":47,"orcid_link":3172,"author_mark":148,"sp_link":3173},359960,"Martin Dresler","martin.dresler@donders.ru.nl","https://orcid.org/0000-0001-7441-3818","https://sciprofiles.com/profile/2640967",{"id":3175,"name":3176,"email":3177,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3178},359961,"Peter Simor","petersimor@gmail.com","https://sciprofiles.com/profile/author/bzROeVFqQ2lSSDFUVGRnL2JIdGhmWUVQUEd4V3V5MHI1YU81eE5BaForVT0=",{"id":3180,"name":3181,"email":3182,"is_corresponding":47,"orcid_link":3183,"author_mark":148,"sp_link":3184},359962,"Stephanie Mazza","stephanie.mazza@univ-lyon1.fr","https://orcid.org/0000-0002-2750-1118","https://sciprofiles.com/profile/3131341",{"id":3186,"name":3187,"email":3188,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3189},359963,"Kerstin Hoedlmoser","kerstin.hoedlmoser@sbg.ac.at","https://sciprofiles.com/profile/1410605",{"id":3191,"name":3192,"email":3193,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3194},359964,"Perrine Ruby","perrine.ruby@inserm.fr","https://sciprofiles.com/profile/author/NFhLbHRiMjZTcjRBWFMxdE9hVXppNkIyMU9nZi84UlZUVm1od20vbVVSbz0=",{"id":3196,"name":3197,"email":3198,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3199},359965,"Rebecca Spencer","rspencer@umass.edu","https://sciprofiles.com/profile/1142359",{"id":3201,"name":3202,"email":3203,"is_corresponding":47,"orcid_link":3204,"author_mark":148,"sp_link":3205},359966,"Genevieve Albouy","genevieve.albouy@kuleuven.be","https://orcid.org/0000-0002-5437-023X","https://sciprofiles.com/profile/2111317",{"id":3207,"name":3208,"email":3209,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3210},359967,"Teodóra Vékony","vekteo@gmail.com","https://sciprofiles.com/profile/author/MGlXOFJLVEFDbVpXQXFDNGNVVVVIc1FocDhUeCs3d3Y4aVBzTWt2cmZmST0=",{"id":3212,"name":3213,"email":3214,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3215},359968,"Manuel Schabus","manuel.schabus@plus.ac.at","https://sciprofiles.com/profile/785057",{"id":3217,"name":3218,"email":3219,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3220},359969,"Karolina Janacsek","janacsekkarolina@gmail.com","https://sciprofiles.com/profile/author/NG5TUVQ3NHZwZm12azU2MmRzZ1ZKMERUR3JrNkFYelBzNFFiU01mVUk1UT0=",{"manuscript_id":3222,"manuscript_version":7,"hash_key":3223,"id":3224,"version":7,"voted":47,"votes":1034,"article_title":3225,"article_abstract":3226,"article_keywords":3227,"top_subject_name":51,"subject_name":3228,"article_type_name":140,"published_at":3229,"download_url":3230,"rank":53,"authors":3231},"202310.1776","7d6fa8bcb3cf57bc3c0dc50ef248afe4",74,"Fantastic Flails and Where to Find Them: the Body of Evidence for the Existence of Flails in the Early and High Medieval Eras in Western, Central, and Southern Europe","Flails are one of the more contentious and misunderstood classes of medieval weaponry, despite their prevalence in popular media: some researchers question their existence entirely and the bulk of historians are sceptical of widespread temporal and geographical prevalence while others, and a significant volume of period evidence, would argue the contrary. While the expansive use of flails in Eastern Europe and Byzantium is familiar, many Central, Western, and Southern European sources are less well-known or largely forgotten, especially those stemming from the later-early and early-high medieval eras (up to 1250). In this work, I collate and discuss the bulk of the available literary references and artistic depictions of flails and their use alongside some of the archaeological finds from Western, Central, and Southern Europe, with an emphasis on the 12\u003Csup>th\u003C/sup> and 13\u003Csup>th\u003C/sup> Centuries. The significance of this volume of evidence is examined, and an assessment of flails as a part of medieval culture and warfare is considered. Collectively, this would suggest that knowledge of flails as instruments of war and associated cultural connotations, if not their actual prevalence and use in warfare, was far more widespread across Europe this time period than has been previously estimated. ","flail; early medieval; high medieval; flexible weapon; ball and chain; morning star; war flail; holy water sprinkler; threshing flail; improvised weapon","History","2023-10-30 05:58:39","/frontend/manuscript/7d6fa8bcb3cf57bc3c0dc50ef248afe4/download_pub",[3232],{"id":3233,"name":3234,"email":3235,"is_corresponding":6,"orcid_link":3236,"author_mark":266,"sp_link":3237},417135,"Alistair Holdsworth","alistair.holdsworth@manchester.ac.uk","https://orcid.org/0000-0002-9250-9650","https://sciprofiles.com/profile/954352",{"manuscript_id":3239,"manuscript_version":7,"hash_key":3240,"id":3241,"version":7,"voted":47,"votes":1905,"article_title":3242,"article_abstract":3243,"article_keywords":3244,"top_subject_name":121,"subject_name":2952,"article_type_name":140,"published_at":3245,"download_url":3246,"rank":53,"authors":3247},"202303.0473","ddd63cb4b6912937ff9980e6077111c0",75,"ChatGPT for Education and Research: Opportunities, Threats, and Strategies","In recent years, the rise of advanced artificial intelligence technologies has had a profound impact on many fields, including education and research. One such technology is ChatGPT, a powerful large language model developed by OpenAI. This technology offers exciting opportunities for students and educators, including personalized feedback, increased accessibility, interactive conversations, lesson preparation, evaluation, and new ways to teach complex concepts. However, ChatGPT poses different threats to the traditional education and research system, including the possibility of cheating on online exams, human-like text generation, diminished critical thinking skills, and difficulties in evaluating information generated by ChatGPT. This study explores potential opportunities and threats that ChatGPT poses to overall education from the perspective of students and educators. Furthermore, for programming learning, we explore how ChatGPT helps students improve their programming skills. To demonstrate this, we conducted different coding-related experiments with ChatGPT, including code generation from problem descriptions, pseudocode generation of algorithms from texts, and code correction. We also verified the generated codes with an online judge system to evaluate their accuracy.","ChatGPT; educational technology; research; programming education; large language model; GPT-3; artificial intelligence","2023-03-28 04:14:47","/frontend/manuscript/ddd63cb4b6912937ff9980e6077111c0/download_pub",[3248,3254],{"id":3249,"name":3250,"email":3251,"is_corresponding":6,"orcid_link":3252,"author_mark":266,"sp_link":3253},323046,"Md. Mostafizer Rahman","mostafiz26@gmail.com","https://orcid.org/0000-0001-9368-7638","https://sciprofiles.com/profile/967526",{"id":3255,"name":3256,"email":3257,"is_corresponding":47,"orcid_link":3258,"author_mark":148,"sp_link":3259},323047,"Yutaka Watanobe","yutaka@u-aizu.ac.jp","https://orcid.org/0000-0002-0030-3859","https://sciprofiles.com/profile/1025878",{"manuscript_id":3261,"manuscript_version":280,"hash_key":3262,"id":409,"version":280,"voted":47,"votes":2193,"article_title":3263,"article_abstract":3264,"article_keywords":3265,"top_subject_name":121,"subject_name":3118,"article_type_name":140,"published_at":3266,"download_url":3267,"rank":53,"authors":3268},"202306.1815","6cd87697e8266ac35ea7e17961f380b5","Paving the Way for Memory Enhancement: Development and Examination of a Neurofeedback System Targeting the Medial Temporal Lobe","Neurofeedback (NF) shows promise in enhancing memory, but its application to the medial temporal lobe (MTL) still needs to be studied. Therefore, we aimed to develop an NF system for the memory function of the MTL and examine neural activity changes, and memory task score changes through NF training. We created a memory NF system using intracranial electrodes to acquire and visualise the neural activity of the MTL during memory encoding. Twenty trials of a tug-of-war game per session were employed for NF and designed to control neural activity bidirectionally (Up/Down condition). NF training was conducted with three patients with intractable epilepsy, and we observed an increasing difference in NF signal between conditions (Up−Down) as NF training progressed. Similarities and negative correlation tendencies between the transition of neural activity and the transition of memory function were also observed. Our findings demonstrate NF's potential to modulate MTL activity and memory encoding. Future research needs further improvements to the NF system to validate its effects on memory functions. Nonetheless, this study represents a crucial step in understanding NF's application to memory and provides valuable insights for developing more efficient memory enhancement strategies.","neurofeedback; memory enhancement; medial temporal lobe; intracranial electrode; bidirectional control; memory encoding; intracranial electroencephalogram; intractable epilepsy","2023-06-28 12:56:15","/frontend/manuscript/6cd87697e8266ac35ea7e17961f380b5/download_pub",[3269,3274,3279,3284,3289,3294,3300],{"id":3270,"name":3271,"email":3272,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":3273},360923,"Koji Koizumi","koizumi@hnl.t.u-tokyo.ac.jp","https://sciprofiles.com/profile/3017227",{"id":3275,"name":3276,"email":3277,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3278},360924,"Naoto Kunii","nkunii@nsurg.jp","https://sciprofiles.com/profile/author/WlJ6T1hGZ3BlUEdFMk5OQlV3VmVhdz09",{"id":3280,"name":3281,"email":3282,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3283},360925,"Kazutaka Ueda","ueda@hnl.t.u-tokyo.ac.jp","https://sciprofiles.com/profile/3116846",{"id":3285,"name":3286,"email":3287,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3288},360926,"Keisuke Nagata","kskngt@gmail.com","https://sciprofiles.com/profile/author/S29RMGFwazBGM3hWOVd2bUVaRlhnWGpFL1RHU1VYNy9lQ2kxa2xwT3czUT0=",{"id":3290,"name":3291,"email":3292,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3293},360927,"Shigeta Fujitani","sfujitani@gmail.com","https://sciprofiles.com/profile/author/UVFWNHJXUlBKYUJtYzUvb1ZCMUVLR1ZoTW5uV0tscDByOHRCelJ3WEFtQT0=",{"id":3295,"name":3296,"email":3297,"is_corresponding":47,"orcid_link":3298,"author_mark":148,"sp_link":3299},360928,"Seijiro Shimada","shimajisan+work@gmail.com","https://orcid.org/0000-0002-6605-1252","https://sciprofiles.com/profile/3100977",{"id":3301,"name":3302,"email":3303,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3304},360929,"Masayuki Nakao","nakao@hnl.t.u-tokyo.ac.jp","https://sciprofiles.com/profile/2150204",{"manuscript_id":3306,"manuscript_version":280,"hash_key":3307,"id":3308,"version":280,"voted":47,"votes":1064,"article_title":3309,"article_abstract":3310,"article_keywords":3311,"top_subject_name":66,"subject_name":2969,"article_type_name":140,"published_at":3312,"download_url":3313,"rank":53,"authors":3314},"202307.1408","19b4ea5e42980f98617d5dd753056349",80,"The Impact of Virtual Reality and Augmented Reality Service Technologies on Consumer Purchase Intention for Fashion Brands","The rapid growth of virtual reality (VR) and augmented reality (AR) services in various industries has stimulated innovation. This study proposes a research framework and theoretical model based on self-determination theory (SDT) to examine consumers’ purchase intentions for VR and AR service technologies. The research scope includes fashion brands that use VR and AR service technologies. The study employs in-depth interviews to identify the key drivers of VR and AR technologies for fashion brands. The research design uses an online survey of 675 fashion brand consumers to collect questionnaire data employing structural equation modeling (SEM) and fuzzy set qualitative comparative analysis fuzzy-set qualitative comparative analysis (fsQCA) to test the research hypotheses and answer the research questions. This study contributes to understanding consumer technology and psychological perceptions about implementing fashion brands with VR and AR service technologies for future service design and marketing. The research findings show that perceived value, perceived enjoyment, perceived informativeness, presence, and consumer experience affect purchase intention positively when using AR/VR service technologies. Further, the results highlight that perceived value, enjoyment, and informativeness affect consumer experience. The results of the FsQCA show that the causal conditions of perceived value, perceived enjoyment, perceived informativeness, presence, and consumer experience are sufficient and necessary for higher purchase intention for consumers in the fashion brand context.","Virtual reality (VR); Augmented reality (AR); fashion brands; fsQCA","2023-10-11 04:44:27","/frontend/manuscript/19b4ea5e42980f98617d5dd753056349/download_pub",[3315],{"id":3316,"name":3317,"email":3318,"is_corresponding":6,"orcid_link":53,"author_mark":266,"sp_link":3319},386323,"Chih-Wen Wu","chihwwu@dragon.nchu.edu.tw","https://sciprofiles.com/profile/1678306",{"manuscript_id":3321,"manuscript_version":7,"hash_key":3322,"id":3323,"version":7,"voted":47,"votes":585,"article_title":3324,"article_abstract":3325,"article_keywords":3326,"top_subject_name":66,"subject_name":2969,"article_type_name":140,"published_at":3327,"download_url":3328,"rank":53,"authors":3329},"202310.1415","82cc9e9fa22474d08b20352fe18df93b",73,"Revolutionizing Green Portfolio Rebalancing: Sustainable Wealth through Innovations in Green Energy","This article explores the relationship between green energy and cryptocurrencies in the sustainable energy finance sector. The research findings contribute to our understanding of the application of green economy practice, enabling investors in financial markets, policymakers, and stakeholders to make informed decisions and develop specific strategies. Adopting the green economy paradigm makes it possible to promote collaboration and innovation by integrating ethical and responsible principles that can improve the overall quality of processes and boost sustainable growth. Cryptocurrencies have been widely used as financial instruments over the last decade. Given the development of the cryptocurrency market and the growing awareness of greener and more energy-efficient tokens, the green economy has become a popular topic for understanding economic and political issues. However, the literature still lacks clear evidence on how cryptocurrencies interact with green energies. Therefore, this study examines the long- and short-term relationships between dirty cryptocurrencies such as Bitcoin (BTC), Ethereum (ETH), clean cryptocurrencies such as Cardano (ADA), Ripple (XRP), Stellar (XLM), and green energies such as ISE Clean Edge Global Wind Energy, S&amp;P Global Clean Energy, S&amp;P TSX Renewable Energy and Clean Technology, Solactive China Clean Energy, in the period from January 2020 to September 2023. The results show that diversification is key, with clean cryptocurrencies such as ADA, XLM and XRP offering diversification opportunities alongside "dirty" cryptocurrencies such as BTC and ETH. Although sustainable energy indices show mixed evidence in the long and short term, they remain relevant for those who focus on clean energy investments. It is also becoming increasingly relevant for investors in sustainable portfolios to assess their environmental impact, especially for energy-intensive cryptocurrencies, and it is advisable to explore sustainable blockchain technologies.","green economy; sustainability; cryptocurrency; safe haven; connectivity","2023-10-23 10:59:09","/frontend/manuscript/82cc9e9fa22474d08b20352fe18df93b/download_pub",[3330,3336],{"id":3331,"name":3332,"email":3333,"is_corresponding":6,"orcid_link":3334,"author_mark":266,"sp_link":3335},415131,"Rui Dias","rui.dias@esce.ips.pt","https://orcid.org/0000-0002-6138-3098","https://sciprofiles.com/profile/825310",{"id":3337,"name":3338,"email":3339,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3340},415132,"Ana Filipa Silva","ana.filipa.silva@ulusofona.pt","https://sciprofiles.com/profile/3163021",{"manuscript_id":3342,"manuscript_version":7,"hash_key":3343,"id":3344,"version":7,"voted":47,"votes":1123,"article_title":3345,"article_abstract":3346,"article_keywords":3347,"top_subject_name":51,"subject_name":3348,"article_type_name":140,"published_at":3349,"download_url":3350,"rank":53,"authors":3351},"202304.0593","3287558538739d91730563e649b94317",79,"Everyone's an Artist? Exploring User Acceptance of AI-Based Painting Systems","Artificial intelligence (AI) applications in different fields are developing rapidly, among which AI painting technology, as an emerging technology, has received wide attention from users for its creativity and efficiency. This study aimed to investigate the factors that influence user acceptance of the use of AIBPS by proposing an extended model that combines the Extended Technology Acceptance Model (ETAM) with the AI-based Painting System (AIBPS).A questionnaire was administered to 528 Chinese participants, using validated factor analysis data and Structural Equation Modeling (SEM) was used to test the hypotheses. The findings showed that hedonic motivation (HM) and perceived trust (PE) had a positive effect (+) on users' perceived usefulness (PU) and perceived ease of use (PEOU), while previous experience (PE) and technical features (TF) had no effect (-) on users' perceived usefulness (PU). This study provides an important contribution to the literature on AIBPS and the evaluation of systems of the same type, which helps to promote the sustainable development of AI in different domains and provides a possible space for further extension of TAM, thus helping to improve the user experience of AIBPS. The results of the study provide insights for system developers and enterprises to better motivate users to use AIBPS.","AI-based painting systems(AIBPS); Technology Acceptance Model (TAM); Behavioral intentions; User experience; Structural Equation Modelling (SEM","Art","2023-04-19 13:27:16","/frontend/manuscript/3287558538739d91730563e649b94317/download_pub",[3352,3358,3364,3369,3374],{"id":3353,"name":3354,"email":3355,"is_corresponding":47,"orcid_link":3356,"author_mark":148,"sp_link":3357},326257,"Junping Xu","xjp1110@kookmin.ac.kr","https://orcid.org/0000-0002-7746-5610","https://sciprofiles.com/profile/1951362",{"id":3359,"name":3360,"email":3361,"is_corresponding":47,"orcid_link":3362,"author_mark":148,"sp_link":3363},326258,"Xiaolin Zhang","colleenzhang@gdut.edu.cn","https://orcid.org/0000-0002-4744-7104","https://sciprofiles.com/profile/2374863",{"id":3365,"name":3366,"email":3367,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3368},326259,"Hui Li","356535293@qq.com","https://sciprofiles.com/profile/2885650",{"id":3370,"name":3371,"email":3372,"is_corresponding":47,"orcid_link":53,"author_mark":148,"sp_link":3373},326260,"Chaemoon Yoo","chaemoonyoo@gmail.com","https://sciprofiles.com/profile/2583063",{"id":3375,"name":3376,"email":3377,"is_corresponding":6,"orcid_link":3378,"author_mark":266,"sp_link":3379},326261,"Younghwan Pan","peterpan@kookmin.ac.kr","https://orcid.org/0000-0003-0745-6687","https://sciprofiles.com/profile/1416445",["Reactive",3381],{"$scookieConsent":3382,"$stoast-ui":3383,"$ssite-config":3385},{"necessary":6,"functional":47,"statistic":47,"marketing":47,"unclassified":47},{"showToast":47,"toastMessage":148,"toastVariant":3384},"neutral",{"env":3386,"name":3387,"url":3388},"production","nuxt-app","http://frontend.preprints.org/",["Set"],["ShallowReactive",3391],{"CFvBbwsS45":53,"mgOlEjP40X":53,"Ya7hZzqdE7":53,"h8MSKkNSc1":53},"/activity/award/announcement?utm_source=ArticlePage&utm_medium=Banner&utm_campaign=award",["Reactive",3394],{"auth":3395,"share-modal":3397,"useHeader":3398,"toUseSidebar":3399},{"userInfo":3396,"isLogin":47},{},{"isShareModalOpen":47,"item":53},{"height":41},{"anchorList":3400,"anchor":41},[3401,3404,3407,3410,3413,3416,3419,3422,3425,3428,3431,3434,3437,3440,3443],{"anchor":3402,"text":3403,"value":41,"exp":6},"#quick-submission","Quick Submission 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