Search results for: Chibuikem Ikwuegbuenyi

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Ikwuegbuenyi</title> <meta name="description" content="Search results for: Chibuikem Ikwuegbuenyi"> <meta name="keywords" content="Chibuikem Ikwuegbuenyi"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Chibuikem Ikwuegbuenyi"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Chibuikem Ikwuegbuenyi</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> How OXA GENE Expression is Implicated in the Treatment Resistance and Poor Prognosis in Glioblastoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Naomi%20Seidu">Naomi Seidu</a>, <a href="https://publications.waset.org/abstracts/search?q=Edward%20Poluyi"> Edward Poluyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chibuikem%20Ikwuegbuenyi"> Chibuikem Ikwuegbuenyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Eghosa%20Morgan"> Eghosa Morgan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The current poor prognosis of glioblastoma has called for the need for an improvement in treatment methods in order to improve its survival rate. Despite the different interventions currently available for this tumor, the average survival is still only a few months. (12-15). The aim is to create a more favorable prognosis and have a reduction in the resistance to treatment currently being experienced, even with surgical interventions and chemotherapy. From the available literature, there is a relationship between the presence of HOX genes (Homeobox genes) and glioblastoma, which could be attributable to the increasing treatment resistance. Hence silencing these genes can be a key to improving survival rates of glioblastoma. A series of studies have highlighted the role that HOX genes play in glioblastoma prognosis. Promotion of human glioblastoma initiation, aggressiveness, and resistance to Temozolomide has been associated with HOXA9. The role of HOX gene expression in cancer stem cells should be studied as it could provide a means of designing CSC-targeted therapies, as CSCs play a part in the initiation and progression of solid tumors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=GBM-%20%20glioblastoma" title="GBM- glioblastoma">GBM- glioblastoma</a>, <a href="https://publications.waset.org/abstracts/search?q=HOXA%20gene-%20homeobox%20genes%20cluster" title=" HOXA gene- homeobox genes cluster"> HOXA gene- homeobox genes cluster</a>, <a href="https://publications.waset.org/abstracts/search?q=signaling%20pathways" title=" signaling pathways"> signaling pathways</a>, <a href="https://publications.waset.org/abstracts/search?q=temozolomide" title=" temozolomide"> temozolomide</a> </p> <a href="https://publications.waset.org/abstracts/153813/how-oxa-gene-expression-is-implicated-in-the-treatment-resistance-and-poor-prognosis-in-glioblastoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153813.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">105</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Peripheral Inflammation and Neurodegeneration; A Potential for Therapeutic Intervention in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lourdes%20Hanna">Lourdes Hanna</a>, <a href="https://publications.waset.org/abstracts/search?q=Edward%20Poluyi"> Edward Poluyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chibuikem%20Ikwuegbuenyi"> Chibuikem Ikwuegbuenyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Eghosa%20Morgan"> Eghosa Morgan</a>, <a href="https://publications.waset.org/abstracts/search?q=Grace%20Imaguezegie"> Grace Imaguezegie</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Degeneration of the central nervous system (CNS), also known as neurodegeneration, describes an age-associated progressive loss of the structure and function of neuronal materials, leading to functional and mental impairments. Main body: Neuroinﬂammation contributes to the continuous worsening of neurodegenerative states which are characterised by functional and mental impairments due to the progressive loss of the structure and function of neu-ronal materials. Some of the most common neurodegenerative diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Whilst neuroinﬂammation is a key contributor to the progression of such disease states, it is not the single cause as there are multiple factors which contribute. Theoretically, non-steroidal anti-inﬂammatory drugs (NSAIDs) have potential to target neuroinﬂammation to reduce the severity of disease states. Whilst some animal models investigating the eﬀects of NSAIDs on the risk of neurodegenerative diseases have shown a beneﬁcial eﬀect, this is not the same ﬁnding. Conclusion: Further investigation using more advanced research methods is required to better understand neuroinﬂammatory pathways and understand if there is still a potential window for NSAID eﬃcacy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=intervention" title="intervention">intervention</a>, <a href="https://publications.waset.org/abstracts/search?q=central%20nervous%20system" title=" central nervous system"> central nervous system</a>, <a href="https://publications.waset.org/abstracts/search?q=neurodegeneration" title=" neurodegeneration"> neurodegeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroinflammation" title=" neuroinflammation"> neuroinflammation</a> </p> <a href="https://publications.waset.org/abstracts/153806/peripheral-inflammation-and-neurodegeneration-a-potential-for-therapeutic-intervention-in-alzheimers-disease-parkinsons-disease-and-amyotrophic-lateral-sclerosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153806.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Examining the Relationship between Concussion and Neurodegenerative Disorders: A Review on Amyotrophic Lateral Sclerosis and Alzheimer’s Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Edward%20Poluyi">Edward Poluyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Eghosa%20Morgan"> Eghosa Morgan</a>, <a href="https://publications.waset.org/abstracts/search?q=Charles%20Poluyi"> Charles Poluyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chibuikem%20Ikwuegbuenyi"> Chibuikem Ikwuegbuenyi</a>, <a href="https://publications.waset.org/abstracts/search?q=Grace%20Imaguezegie"> Grace Imaguezegie</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Current epidemiological studies have examined the associations between moderate and severe traumatic brain injury (TBI) and their risks of developing neurodegenerative diseases. Concussion, also known as mild TBI (mTBI), is however quite distinct from moderate or severe TBIs. Only few studies in this burgeoning area have examined concussion—especially repetitive episodes—and neurodegenerative diseases. Thus, no definite relationship has been established between them. Objectives : This review will discuss the available literature linking concussion and amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD). Materials and Methods: Given the complexity of this subject, a realistic review methodology was selected which includes clarifying the scope and developing a theoretical framework, developing a search strategy, selection and appraisal, data extraction, and synthesis. A detailed literature matrix was set out in order to get relevant and recent findings on this topic. Results: Presently, there is no objective clinical test for the diagnosis of concussion because the features are less obvious on physical examination. Absence of an objective test in diagnosing concussion sometimes leads to skepticism when confirming the presence or absence of concussion. Intriguingly, several possible explanations have been proposed in the pathological mechanisms that lead to the development of some neurodegenerative disorders (such as ALS and AD) and concussion but the two major events are deposition of tau proteins (abnormal microtubule proteins) and neuroinflammation, which ranges from glutamate excitotoxicity pathways and inflammatory pathways (which leads to a rise in the metabolic demands of microglia cells and neurons), to mitochondrial function via the oxidative pathways. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amyotrophic%20lateral%20sclerosis" title="amyotrophic lateral sclerosis">amyotrophic lateral sclerosis</a>, <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%27s%20disease" title=" Alzheimer's disease"> Alzheimer's disease</a>, <a href="https://publications.waset.org/abstracts/search?q=mild%20traumatic%20brain%20injury" title=" mild traumatic brain injury"> mild traumatic brain injury</a>, <a href="https://publications.waset.org/abstracts/search?q=neurodegeneration" title=" neurodegeneration"> neurodegeneration</a> </p> <a href="https://publications.waset.org/abstracts/153802/examining-the-relationship-between-concussion-and-neurodegenerative-disorders-a-review-on-amyotrophic-lateral-sclerosis-and-alzheimers-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153802.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">89</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a 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Search results for: Chibuikem Ikwuegbuenyi