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Lexaria Signs Contract For New DehydraTECH GLP-1 Biodistribution Study - Lexaria Bioscience

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(NASDAQ:LEXX)(NASDAQ:LEXXW) (the &#8220;Company&#8221; or &#8220;Lexaria&#8221;), a global innovator in drug delivery platforms, announces it has engaged a contract research organization to perform the world&#8217;s first-ever fluorescently tagged DehydraTECH-semaglutide (&#8220;FTS&#8221;) rodent biodistribution study (the &#8220;Study&#8221;). 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(NASDAQ:LEXX)(NASDAQ:LEXXW) (the &#8220;Company&#8221; or &#8220;Lexaria&#8221;), a global innovator in drug delivery platforms, announces it has engaged a contract research organization to perform the world&#8217;s first-ever fluorescently tagged DehydraTECH-semaglutide (&#8220;FTS&#8221;) rodent <a rel="nofollow" href="https://pr.report/48u8">biodistribution study</a> (the &#8220;Study&#8221;).</p> <p>Distribution of a drug once it enters the body can provide vital clues as to the understanding of that drug&#8217;s ability to bind with targeted receptor cells, avoid concentration at physical sites that might be prone to fostering adverse side effects, and increase the drug&#8217;s ultimate efficacy. Lexaria hopes to discover whether the DehydraTECH processing of semaglutide improves its biodistribution in any significant way compared to conventional orally administered semaglutide formulation practices.</p> <p>The FTS will be tracked via fluorescent imaging detection to evidence how and where the semaglutide distributes and localizes following oral ingestion in Sprague-Dawley rats. Later in the Study, the animals will be euthanized and various key tissues will be examined including the brain, pancreas, lung, kidney, liver and heart for more detailed fluorescent imaging detection showing very specific tissue localization patterns and concentrations.</p> <p>Lexaria has already begun the early-stage collaboration with the third-party laboratory that will synthesize the FTS that will then be used to create the DehydraTECH-semaglutide test articles. There will be two different test articles manufactured and tested:</p> <ul style="list-style-type:disc"> <li> <p>FTS will be combined with ingredients in the proportions used within the Rybelsus&#174; orally-administered product sold today designed to mimic Rybelsus&#174; performance, without DehydraTECH processing.</p> </li> <li> <p>FTS will be combined with patented DehydraTECH ingredients and processes to evidence potential biodistribution differences when DehydraTECH is used compared to the Rybelsus&#174;-mimicking control FTS formulation.</p> </li> </ul> <p>The Study will also include use of certain glucagon-like peptide-1 (&#8220;GLP-1&#8221;) receptor specific antibodies detectable through an immunofluorescence methodology to allow the analytical laboratory to confirm the extent of GLP-1 receptor binding of the two FTS formulations in the tissue samples taken from the animals, providing an additional detailed measure of the FTS distribution and localization patterns.</p> <p>Results from the Study will enhance any future communications between Lexaria and prospective industry partners. Study work has already begun with completion and final reporting expected in May, 2025.</p> <p><strong>About Lexaria Bioscience Corp. &amp; DehydraTECH</strong></p> <p>DehydraTECH&#8482; is Lexaria&#8217;s patented drug delivery formulation and processing platform technology which improves the way active pharmaceutical ingredients (APIs) enter the bloodstream through oral delivery. Since 2016, Lexaria has developed and investigated DehydraTECH with a variety of beneficial molecules in oral and topical formats. DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption and has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier, which Lexaria believes to be of particular importance for centrally active compounds. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 46 patents granted and many patents pending worldwide. For more information, please visit <a rel="nofollow" href="https://pr.report/48u9">www.lexariabioscience.com</a>.</p> <p><strong>CAUTION REGARDING FORWARD-LOOKING STATEMENTS</strong></p> <p>This press release includes forward-looking statements. Statements as such term is defined under applicable securities laws. These statements may be identified by words such as &#8220;anticipate,&#8221; &#8220;if,&#8221; &#8220;believe,&#8221; &#8220;plan,&#8221; &#8220;estimate,&#8221; &#8220;expect,&#8221; &#8220;intend,&#8221; &#8220;may,&#8221; &#8220;could,&#8221; &#8220;should,&#8221; &#8220;will,&#8221; and other similar expressions. Such forward-looking statements in this press release include, but are not limited to, statements by the company relating the Company&#8217;s ability to carry out research initiatives, receive regulatory approvals or grants or experience positive effects or results from any research or study. Such forward-looking statements are estimates reflecting the Company&#8217;s best judgment based upon current information and involve a number of risks and uncertainties, and there can be no assurance that the Company will actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements. As such, you should not place undue reliance on these forward-looking statements. Factors which could cause actual results to differ materially from those estimated by the Company include, but are not limited to, government regulation and regulatory approvals, managing and maintaining growth, the effect of adverse publicity, litigation, competition, scientific discovery, the patent application and approval process, potential adverse effects arising from the testing or use of products utilizing the DehydraTECH technology, the Company&#8217;s ability to maintain existing collaborations and realize the benefits thereof, delays or cancellations of planned R&amp;D that could occur related to pandemics or for other reasons, and other factors which may be identified from time to time in the Company&#8217;s public announcements and periodic filings with the US Securities and Exchange Commission on EDGAR. The Company provides links to third-party websites only as a courtesy to readers and disclaims any responsibility for the thoroughness, accuracy or timeliness of information at third-party websites. There is no assurance that any of Lexaria&#8217;s postulated uses, benefits, or advantages for the patented and patent-pending technology will in fact be realized in any manner or in any part. No statement herein has been evaluated by the Food and Drug Administration (FDA). Lexaria-associated products are not intended to diagnose, treat, cure or prevent any disease. Any forward-looking statements contained in this release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements or links to third-party websites contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.</p> <p><strong>INVESTOR CONTACT:</strong></p> <p><strong>George Jurcic &#8211; Head of Investor Relations</strong><br /><a rel="nofollow" href="/cdn-cgi/l/email-protection#aec7dceec2cbd6cfdcc7cfccc7c1ddcdc7cbc0cdcb80cdc1c3"><span class="__cf_email__" data-cfemail="e78e95a78b829f86958e86858e8894848e82898482c984888a">[email&#160;protected]</span></a><br />Phone: 250-765-6424, ext 202</p> <p><strong>SOURCE: </strong>Lexaria Bioscience Corp.</p> <p>View the original <a href='https://www.accesswire.com/942382/lexaria-signs-contract-for-new-dehydratech-glp-1-biodistribution-study'>press release</a> on accesswire.com</p> </div> <div 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