Active Clinical Trials for DIPG & DMG

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href="/treatment/patient-care/fatigue/">Fatigue</a></li> <li class="nonselected"><a href="/treatment/patient-care/breathing-issues/">Breathing Issues</a></li> <li class="nonselected"><a href="/treatment/patient-care/seizures/">Seizures</a></li> <li class="nonselected"><a href="/treatment/patient-care/sleeping-issues/">Sleeping Issues</a></li> <li class="nonselected"><a href="/treatment/patient-care/ports-and-catheters/">Ports and Catheters</a></li> <li class="nonselected"><a href="/treatment/patient-care/complementary-and-alternative-medicines/">Complementary and Alternative Medicines</a></li> <li class="nonselected"><a href="/treatment/patient-care/practical-care-issues/">Practical Care Issues</a></li> <li class="nonselected"><a href="/treatment/patient-care/communication-challenges/">Communication Challenges</a></li> <li class="nonselected"><a href="/treatment/patient-care/caring-for-your-children-and-yourselves/">Caring for Your Children and Yourselves</a></li> <li class="nonselected"><a href="/treatment/patient-care/other-helpful-tips/">Other Helpful Tips</a></li> <li class="nonselected"><a href="/treatment/patient-care/making-difficult-decisions/">Making Difficult Decisions</a></li> <li class="nonselected"><a href="/treatment/patient-care/parents-advice-for-other-parents/">Parent's Advice for Other Parents</a></li> </ul> </li> </ul> </nav> <p><strong>Feeling overwhelmed?</strong><br />Considering signing up at <a href="https://dipgwarrior.org" target="_blank">dipgwarrior.org</a> so we can point you in the right direction.</p> <a class="btn secondary" href="https://dipgwarrior.org" target="_blank" role="button" title="Learn More">Learn more</a> </aside> <article class="col-md-9"> <h1>DIPG / DMG Clinical Trials</h1> <div class="alert alert-info" style="padding: 10px 20px 10px 20px; font-size: 14px;"> <h6>The newest version of Trial Finder is live!</h6> <p>What you see below is just a preview of what is available within the Trial Finder system! New features include:</p> <ul> <li>Customized <strong>daily email notifications</strong> about the trials you care about</li> <li>Search trials by keywords or local to your area</li> <li>Favorite specific trials</li> <li>Saved searches</li> <li>And more!</li> </ul> <p style="margin-bottom: 0;"><a class="btn primary btn-sm" href="https://trials.dipg.org" role="button">Sign-up for the Trial Finder</a></p> </div> <hr /> <p>Trials current as of: 2024-11-23 </p> <form method="get" id="status"> <div class="" style="margin-left: 15px; margin-right: 15px;"> <div class="row"> <div class="col-xs-12" style="font-size: 14px; background-color: #79bfe8; padding: 10px;"><span style="font-size: 12px; color: #FFF">Filter Results:</span><br /> <select name="status" style="margin-top: 5px;"> <option value="Recruiting" selected="selected">Recruiting</option> <option value="Not yet recruiting">Not yet recruiting</option> <option value="Active, not recruiting">Not recruiting</option> ") </select> </div> </div> </div> </form> <br /><br /> <div class="row"> <div class="col-sm-12"> <div class="row trial-head"> <div class="col-md-8">Clinical Trial</div> <div class="col-md-4">Sponsor</div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03033992" target="_blank">Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG</a> <br /><small><em><strong>Last Updated: 2024-06-19</strong><br />Originally Posted: 2017-01-27</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Pediatric Brain Tumor Consortium</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT06221553" target="_blank">Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG</a> <br /><small><em><strong>Last Updated: 2024-04-19</strong><br />Originally Posted: 2024-01-24</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Chulalongkorn University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04485559" target="_blank">Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)</a> <br /><small><em><strong>Last Updated: 2024-04-17</strong><br />Originally Posted: 2020-07-24</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of California, San Francisco</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04201457" target="_blank">A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration</a> <br /><small><em><strong>Last Updated: 2024-04-05</strong><br />Originally Posted: 2019-12-17</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Pediatric Brain Tumor Consortium</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05956821" target="_blank">Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age</a> <br /><small><em><strong>Last Updated: 2024-03-15</strong><br />Originally Posted: 2023-07-21</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of Miami</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT06305910" target="_blank">CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults</a> <br /><small><em><strong>Last Updated: 2024-03-12</strong><br />Originally Posted: 2024-03-12</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>OX2 Therapeutics</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT06297512" target="_blank">Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).</a> <br /><small><em><strong>Last Updated: 2024-03-07</strong><br />Originally Posted: 2024-03-07</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Meyer Children's Hospital IRCCS</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05123534" target="_blank">A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG</a> <br /><small><em><strong>Last Updated: 2024-01-31</strong><br />Originally Posted: 2021-11-17</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>SonALAsense, Inc.</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT06140719" target="_blank">xPedite: An Observational Study to Expedite DIPG and DMG Research</a> <br /><small><em><strong>Last Updated: 2024-01-23</strong><br />Originally Posted: 2023-11-20</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>xCures</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04049669" target="_blank">Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG</a> <br /><small><em><strong>Last Updated: 2023-12-19</strong><br />Originally Posted: 2019-08-08</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Augusta University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05099003" target="_blank">A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)</a> <br /><small><em><strong>Last Updated: 2023-12-04</strong><br />Originally Posted: 2021-10-29</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>National Cancer Institute (NCI)</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05580562" target="_blank">ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)</a> <br /><small><em><strong>Last Updated: 2023-11-28</strong><br />Originally Posted: 2022-10-14</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Chimerix</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04870944" target="_blank">CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma</a> <br /><small><em><strong>Last Updated: 2023-11-24</strong><br />Originally Posted: 2021-05-04</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Children's Oncology Group</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03709680" target="_blank">Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors</a> <br /><small><em><strong>Last Updated: 2023-11-22</strong><br />Originally Posted: 2018-10-17</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Pfizer</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04250064" target="_blank">A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma</a> <br /><small><em><strong>Last Updated: 2023-11-22</strong><br />Originally Posted: 2020-01-31</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Tata Memorial Centre</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05077735" target="_blank">Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study</a> <br /><small><em><strong>Last Updated: 2023-11-21</strong><br />Originally Posted: 2021-10-14</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Mayo Clinic</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05298995" target="_blank">GD2-CAR T Cells for Pediatric Brain Tumours</a> <br /><small><em><strong>Last Updated: 2023-11-18</strong><br />Originally Posted: 2022-03-28</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Bambino Gesù Hospital and Research Institute</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03598244" target="_blank">Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors</a> <br /><small><em><strong>Last Updated: 2023-11-18</strong><br />Originally Posted: 2018-07-26</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>National Cancer Institute (NCI)</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT02359565" target="_blank">Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma</a> <br /><small><em><strong>Last Updated: 2023-11-07</strong><br />Originally Posted: 2015-02-10</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>National Cancer Institute (NCI)</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05615623" target="_blank">Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG</a> <br /><small><em><strong>Last Updated: 2023-11-03</strong><br />Originally Posted: 2022-11-14</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>InSightec</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05630209" target="_blank">Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG</a> <br /><small><em><strong>Last Updated: 2023-11-03</strong><br />Originally Posted: 2022-11-29</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>InSightec</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04732065" target="_blank">ONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC 023)</a> <br /><small><em><strong>Last Updated: 2023-10-27</strong><br />Originally Posted: 2021-02-01</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of California, San Francisco</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04541082" target="_blank">Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms</a> <br /><small><em><strong>Last Updated: 2023-10-26</strong><br />Originally Posted: 2020-09-09</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Chimerix</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05500508" target="_blank">Oral AMXT 1501 Dicaprate in Combination With IV DFMO</a> <br /><small><em><strong>Last Updated: 2023-10-19</strong><br />Originally Posted: 2022-08-15</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Aminex Therapeutics, Inc.</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04238819" target="_blank">A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors</a> <br /><small><em><strong>Last Updated: 2023-10-11</strong><br />Originally Posted: 2020-01-23</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Eli Lilly and Company</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04978727" target="_blank">A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma</a> <br /><small><em><strong>Last Updated: 2023-10-10</strong><br />Originally Posted: 2021-07-27</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Pediatric Brain Tumor Consortium</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03101813" target="_blank">International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository</a> <br /><small><em><strong>Last Updated: 2023-10-04</strong><br />Originally Posted: 2017-04-05</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Children's Hospital Medical Center, Cincinnati</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04655404" target="_blank">A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion</a> <br /><small><em><strong>Last Updated: 2023-09-29</strong><br />Originally Posted: 2020-12-07</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Nationwide Children's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05478837" target="_blank">Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma</a> <br /><small><em><strong>Last Updated: 2023-09-28</strong><br />Originally Posted: 2022-07-28</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of California, San Francisco</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT06000787" target="_blank">MCT for the Harvard/UCSF ROBIN Center</a> <br /><small><em><strong>Last Updated: 2023-09-28</strong><br />Originally Posted: 2023-08-21</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Brigham and Women's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04837547" target="_blank">PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy</a> <br /><small><em><strong>Last Updated: 2023-09-28</strong><br />Originally Posted: 2021-04-08</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Wake Forest University Health Sciences</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05169944" target="_blank">Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors</a> <br /><small><em><strong>Last Updated: 2023-09-28</strong><br />Originally Posted: 2021-12-27</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of California, San Francisco</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03652545" target="_blank">Multi-antigen T Cell Infusion Against Neuro-oncologic Disease</a> <br /><small><em><strong>Last Updated: 2023-09-21</strong><br />Originally Posted: 2018-08-29</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Children's National Research Institute</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04758533" target="_blank">Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy</a> <br /><small><em><strong>Last Updated: 2023-09-13</strong><br />Originally Posted: 2021-02-17</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Hospital Infantil Universitario Niño Jesús, Madrid, Spain</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04943848" target="_blank">rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG</a> <br /><small><em><strong>Last Updated: 2023-09-11</strong><br />Originally Posted: 2021-06-29</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Ann & Robert H Lurie Children's Hospital of Chicago</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05544526" target="_blank">CAR T Cells to Target GD2 for DMG</a> <br /><small><em><strong>Last Updated: 2023-09-11</strong><br />Originally Posted: 2022-09-16</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University College, London</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04099797" target="_blank">C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)</a> <br /><small><em><strong>Last Updated: 2023-09-01</strong><br />Originally Posted: 2019-09-23</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Baylor College of Medicine</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03605550" target="_blank">A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma</a> <br /><small><em><strong>Last Updated: 2023-08-29</strong><br />Originally Posted: 2018-07-30</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Nationwide Children's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05413304" target="_blank">Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis</a> <br /><small><em><strong>Last Updated: 2023-08-25</strong><br />Originally Posted: 2022-06-10</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>National Institutes of Health Clinical Center (CC)</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04196413" target="_blank">GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)</a> <br /><small><em><strong>Last Updated: 2023-08-08</strong><br />Originally Posted: 2019-12-12</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Stanford University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03126266" target="_blank">Re-Irradiation of Progressive or Recurrent DIPG</a> <br /><small><em><strong>Last Updated: 2023-08-02</strong><br />Originally Posted: 2017-04-24</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of Calgary</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04532229" target="_blank">Nimotuzumab in Combined With Concurrent Radiochemotherapy in the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Children</a> <br /><small><em><strong>Last Updated: 2023-07-27</strong><br />Originally Posted: 2020-08-31</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Biotech Pharmaceutical Co., Ltd.</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04749641" target="_blank">Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma</a> <br /><small><em><strong>Last Updated: 2023-07-27</strong><br />Originally Posted: 2021-02-11</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Beijing Tiantan Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05768880" target="_blank">Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors</a> <br /><small><em><strong>Last Updated: 2023-06-29</strong><br />Originally Posted: 2023-03-15</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Seattle Children's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04773782" target="_blank">A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling</a> <br /><small><em><strong>Last Updated: 2023-06-15</strong><br />Originally Posted: 2021-02-26</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Blueprint Medicines Corporation</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05835687" target="_blank">B7-H3-CAR T Cells for Pediatric CNS Tumors</a> <br /><small><em><strong>Last Updated: 2023-06-01</strong><br />Originally Posted: 2023-04-28</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>St. Jude Children's Research Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04771897" target="_blank">A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)</a> <br /><small><em><strong>Last Updated: 2023-05-24</strong><br />Originally Posted: 2021-02-25</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Bexion Pharmaceuticals, Inc.</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT01837862" target="_blank">A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas</a> <br /><small><em><strong>Last Updated: 2023-04-13</strong><br />Originally Posted: 2013-04-23</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Northwell Health</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05259605" target="_blank">Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification</a> <br /><small><em><strong>Last Updated: 2023-03-30</strong><br />Originally Posted: 2022-02-28</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>European Organisation for Research and Treatment of Cancer - EORTC</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04808245" target="_blank">A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas</a> <br /><small><em><strong>Last Updated: 2023-03-29</strong><br />Originally Posted: 2021-03-22</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>German Cancer Research Center</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04908176" target="_blank">A Drug-drug Interaction Study of Avapritinib and Midazolam</a> <br /><small><em><strong>Last Updated: 2023-03-13</strong><br />Originally Posted: 2021-06-01</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Blueprint Medicines Corporation</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05762419" target="_blank">FUS Etoposide for DMG - A Feasibility Study</a> <br /><small><em><strong>Last Updated: 2023-03-09</strong><br />Originally Posted: 2023-03-09</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Columbia University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT02992015" target="_blank">Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma</a> <br /><small><em><strong>Last Updated: 2023-02-17</strong><br />Originally Posted: 2016-12-14</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of Colorado, Denver</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT01106794" target="_blank">Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma</a> <br /><small><em><strong>Last Updated: 2023-02-10</strong><br />Originally Posted: 2010-04-20</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Children's National Research Institute</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05717712" target="_blank">Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma</a> <br /><small><em><strong>Last Updated: 2023-02-08</strong><br />Originally Posted: 2023-02-08</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Capital Medical University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05717699" target="_blank">Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma</a> <br /><small><em><strong>Last Updated: 2023-02-08</strong><br />Originally Posted: 2023-02-08</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Capital Medical University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05476939" target="_blank">Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0</a> <br /><small><em><strong>Last Updated: 2023-01-30</strong><br />Originally Posted: 2022-07-27</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Gustave Roussy, Cancer Campus, Grand Paris</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05278208" target="_blank">Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors or Meningiomas Expressing SST2A</a> <br /><small><em><strong>Last Updated: 2023-01-18</strong><br />Originally Posted: 2022-03-14</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Nationwide Children's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05135975" target="_blank">A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors</a> <br /><small><em><strong>Last Updated: 2022-12-21</strong><br />Originally Posted: 2021-11-26</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Nationwide Children's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04185038" target="_blank">Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors</a> <br /><small><em><strong>Last Updated: 2022-12-19</strong><br />Originally Posted: 2019-12-04</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Seattle Children's Hospital</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04670016" target="_blank">HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers</a> <br /><small><em><strong>Last Updated: 2022-11-10</strong><br />Originally Posted: 2020-12-17</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of Calgary</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05536024" target="_blank">Combing a Deep Learning-Based Radiomics With Liquid Biopsy for Preoperative and Non-invasive Diagnosis of Glioma</a> <br /><small><em><strong>Last Updated: 2022-09-12</strong><br />Originally Posted: 2022-09-12</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Second Affiliated Hospital of Nanchang University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT01884740" target="_blank">Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22</a> <br /><small><em><strong>Last Updated: 2022-08-09</strong><br />Originally Posted: 2013-06-24</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Weill Medical College of Cornell University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT02644291" target="_blank">Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors</a> <br /><small><em><strong>Last Updated: 2022-06-23</strong><br />Originally Posted: 2015-12-31</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT03243461" target="_blank">International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)</a> <br /><small><em><strong>Last Updated: 2022-06-06</strong><br />Originally Posted: 2017-08-09</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>University of Göttingen</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT04264143" target="_blank">CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas</a> <br /><small><em><strong>Last Updated: 2022-03-10</strong><br />Originally Posted: 2020-02-11</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Columbia University</span> </div> </div> <div class="row trial"> <div class="col-md-8 trial-name"> <p><a href="https://clinicaltrials.gov/show/NCT05120518" target="_blank">Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells</a> <br /><small><em><strong>Last Updated: 2021-11-15</strong><br />Originally Posted: 2021-11-15</em></small></p> </div> <div class="col-md-4 trial-chair"> <span>Ann & Robert H Lurie Children's Hospital of Chicago</span> </div> </div> </div> </div> <footer class="footnotes"> <p>Content courtesy of clinicaltrials.gov, clinicaltrialsregister.eu, and聽anzctr.org.au</p> </footer> </article> </div> <script> $( "#status" ).change(function() { $(this).submit(); }); </script> </div> </main> <footer id="footer"> DIPG.org is proud to be a part of <strong>The Cure Starts Now Cancer Resource Network</strong>:<br /><a href="https://thecurestartsnow.org" target="_blank">The Cure Starts Now</a> | <a href="https://curecancer.org" target="_blank">CureCancer.org</a> | <a href="https://dipg.org" target="_blank">DIPG.org</a> | <a href="https://medulloblastoma.org" target="_blank">Medulloblastoma.org</a><br /><br />10280 Chester Road, Cincinnati, Ohio 45215 | 513-772-4888<br />Copyright 2022 The Cure Starts Now. 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