Human IL-17/IL-17A Antibody (AF-317-NA) by R&D Systems, Part of Bio-Techne

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that? I need for flow cytometer in sheep or goat.","acceptedAnswer":{"@type":"Answer","text":"Unfortunately, we have neither a CD4 antibody nor an IL-17 antibody that has been validated in sheep or goat, although if you would like to try one you would again be eligible for our Innovators Reward Program. 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data-time_datapoints="0.80522608757019" data-time_template="-0.80522608757019" data-time_post_epcc="0.76856088638306" data-time_epcc="0.80522608757019" data-render_time="Friday 22nd of November 2024 09:36:03 AM" data-fallback="FALSE" data-time_to_process_data="0.16376876831055" class="px-4 container" class="container"> <div id="above-fold-section"> <div class="mb-2 o__product-summary"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="validation-badges-header-wrapper"> <a class="biological-validation mr-3 d-inline-flex mt-1" href="/reagents/antibodies/antibody-validation" target="_blank" title="Biological Validation"></a> </div> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Human IL-17/IL-17A Antibody <span class="rounded align-middle p-1 badge best-seller" title="Best Seller">Best Seller</span> </h1> <h2 class="font-weight-normal h4"> R&D Systems, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">AF-317-NA</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div id="reviews_quick_link_wrapper" class="col-auto d-flex align-self-center"> <div id="reviews_quicklink"> <a href="#reviews" id="review_count_quicklink" class="reviews" data-tab="2"> <span class="review_stars review_stars_4"></span> <span class="font-weight-bold"></span> (9) </a> </div> </div> <div id="citation_quick_link_wrapper" class="col-auto d-flex align-self-center"> <div id="citation_quicklink"> <a href="#citations" id="citation_count" data-tab="2" class="citations"> <span class="icon-icon-product-citations d-none d-lg-inline pr-1"></span> Citations (136)  </a> </div> </div> <div class="col-auto d-flex align-self-center"> <div> <div class="px-0 my-1" id="datasheet-summary-wrapper" data-section="section-base--top-jumplink"> <article class="top-jumplink-wrapper"> <span class="icon-icon-pdf text-error-red"></span> <a href="#product-documents" class="product-documents-top-link" rel="nofollow">Product Datasheet / COA / SDS</a> </article> </div> </div> </div> </div> </div> <div id="new_version_available"> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" alt="R&D Systems, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> <div class="row border-top mb-2" id="images-orderdetail-wrapper"> <div class="col-xl-6 mt-2" id="images-wrapper" data-section="image_summary"> <div id="image-tree" data-section="component-product-image-tree" class="vertical lightbox" data-mdb-zoom-effect="true"> <div id="product-image-gallery" class="row"> <div class="col-md-2 d-none d-md-block"> <ul class="list-inline m-0"> <li data-id="1" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL17_AF317NA_Immunohistochemistry_20615.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL17_AF317NA_Immunohistochemistry_20615.jpg" alt="IL-17/IL-17A antibody in Human Tonsil by Immunohistochemistry (IHC-P)." title="IL‑17/IL‑17A in Human Tonsil." data-caption="IL-17/IL-17A was detected in immersion fixed paraffin-embedded sections of human tonsil using Goat Anti-Human IL-17/IL-17A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (<a href="/p/secondary-antibodies/goat-igg-visucyte-hrp-polymer_vc004" target="_self">VC004</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/IL17_AF317NA_Immunohistochemistry_20615.jpg" data-id="0" data-application="https://resources.bio-techne.com/images/products/antibody/IL17_AF317NA_Immunohistochemistry_20615.jpg" class="lazy" /> </div> </li> <li data-id="2" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Immunoprecipitation_12634.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Immunoprecipitation_12634.jpg" alt="Immunoprecipitation of Human IL‑17." title="Immunoprecipitation of Human IL‑17." data-caption="Human IL-17 was immunoprecipitated from 100 µg of human primary differentiated Th17 cell lysate following incubation with 3 µg Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) or control antibody (<a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>) overnight at 4 °C. IL-17-antibody complexes were absorbed using Protein G Sepharose. Immunoprecipitated IL-17 was detected by Western blot using 1 µg/mL Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA). View our recommended buffer recipes for immunoprecipitation." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Immunoprecipitation_12634.jpg" data-id="1" data-application="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Immunoprecipitation_12634.jpg" class="lazy" /> </div> </li> <li data-id="3" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Flow_Cytometry_3414.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Flow_Cytometry_3414.jpg" alt="Detection of IL-17 antibody in Human PBMCs antibody by Flow Cytometry." title="Detection of IL‑17 in Human PBMCs by Flow Cytometry." data-caption="Human peripheral blood mononuclear cells were unstimulated (light orange filled histogram) or treated with 50 ng/mL PMA and 250 ng/mL Ca <sup>2+</sup>ionomycin for 16 hours, then stained with Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA, dark orange filled histogram) or isotype control antibody (<a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (<a href="/p/secondary-antibodies/goat-igg-h-l-apc-conjugated-antibody_f0108" target="_self">F0108</a>). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin." data-badges='<span class="biological-validation"></span>' data-mdb-img="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Flow_Cytometry_3414.jpg" data-id="2" data-application="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Flow_Cytometry_3414.jpg" class="lazy" /> </div> </li> <li data-id="4" class="none"> <i data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Block_Neutralize_8693.jpg" data-alt="IL-6 Secretion Induced by IL-17 and Neutralization by Human IL-17 Antibody." title="IL‑6 Secretion Induced by IL‑17 and Neutralization by Human IL‑17 Antibody." data-caption="Recombinant Human IL-17 (<a href="/p/proteins-enzymes/recombinant-human-il-17a-protein-cf_317-ilb" target="_self">317-ILB</a>) stimulates IL-6 secretion in NIH/3T3 mouse embryonic fibroblasts in a dose-dependent manner (orange line), as measured by the mouse IL-6 Quantikine ELISA Kit (Catalog # M6000B). IL-6 secretion elicited by Recombinant Human IL-17 (15 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA). The ND<sub>50</sub> is typically 0.02-0.12 µg/mL." data-badges="" data-application="Neutralization" class="none"></i> </li> <li data-id="5" class="none"> <i data-src="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410485438.jpg" data-alt="Detection of Human IL-17/IL-17A by Immunohistochemistry" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Expression of psoriasis‐related cytokines in paradoxical psoriasiform reactions. Immunohistochemistry analysis performed on paradoxical skin lesions obtained from patients 1 (Pt1) and 2 (Pt2) shows similar values of IL‐17A+ cells, a reduction of dermal IFN‐ gamma+ cells and an increase of IL‐22+ or IL‐36 gamma+ cells, when compared with psoriatic skin lesions. LS and NLS skin of the same psoriatic patient (n = 3) was analyzed. Graphs show the mean of number of positive cells + SD per three sections. One out of three representative stainings is shown. *p < 0.01, **p < 0.05, versus classical psoriasis. Scale bars, 200 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31577850), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Immunohistochemistry" class="none"></i> </li> <li data-id="6" class="none"> <i data-src="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410481145.jpg" data-alt="Detection of Human IL-17/IL-17A by Immunohistochemistry" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Inflammatory cell infiltrates of early acne lesions in immunohistochemistry.Representative immunohistochemical staining showing IL-17A+ cells in early acne lesion (a). Staining of IL-17A+ and CD3+ cells shows that IL-17A (in green) and CD3 (in red) were detected in acne vulgaris lesions. Cell nuclei were counterstained in blue. Arrows indicate IL-17A and CD3 double positive cells (b). T-bet+ cells (c) were more numerous than IL-17A+ cells or Foxp3+ cells (d) in the lesional acne skin. Large number of CD4+ cells (e), mostly lymphocytes, was seen around pilosebaceous unit and perivascularly. CD8+ cells (f) were fewer in number than CD4+ cells. Large number of CD68+ macrophages (g) and a few CD83+ cells (h), which are mature dendritic cells, were detected around sebaceous follicles. (Bar = 200 µm; in the insets bar = 50 µm). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25153527), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Immunohistochemistry" class="none"></i> </li> <li data-id="7" class="none"> <i data-src="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410484368.jpg" data-alt="Detection of Human IL-17/IL-17A by Immunohistochemistry" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Inflammatory cell infiltrates of early acne lesions in immunohistochemistry.Representative immunohistochemical staining showing IL-17A+ cells in early acne lesion (a). Staining of IL-17A+ and CD3+ cells shows that IL-17A (in green) and CD3 (in red) were detected in acne vulgaris lesions. Cell nuclei were counterstained in blue. Arrows indicate IL-17A and CD3 double positive cells (b). T-bet+ cells (c) were more numerous than IL-17A+ cells or Foxp3+ cells (d) in the lesional acne skin. Large number of CD4+ cells (e), mostly lymphocytes, was seen around pilosebaceous unit and perivascularly. CD8+ cells (f) were fewer in number than CD4+ cells. Large number of CD68+ macrophages (g) and a few CD83+ cells (h), which are mature dendritic cells, were detected around sebaceous follicles. (Bar = 200 µm; in the insets bar = 50 µm). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25153527), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Immunohistochemistry" class="none"></i> </li> <li class="list-inline-item"> <div class="image-slider-container"> <div class="lightbox product-image-lightbox"> <div class="lightbox border text-bt-dark-blue text-center search_result_thumbnail_image bg-light-gray rounded" style="padding: 20px 10px" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Expression of psoriasis‐related cytokines in paradoxical psoriasiform reactions. Immunohistochemistry analysis performed on paradoxical skin lesions obtained from patients 1 (Pt1) and 2 (Pt2) shows similar values of IL‐17A+ cells, a reduction of dermal IFN‐ gamma+ cells and an increase of IL‐22+ or IL‐36 gamma+ cells, when compared with psoriatic skin lesions. LS and NLS skin of the same psoriatic patient (n = 3) was analyzed. Graphs show the mean of number of positive cells + SD per three sections. One out of three representative stainings is shown. *p < 0.01, **p < 0.05, versus classical psoriasis. Scale bars, 200 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31577850), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410485438.jpg" data-id="3" data-application="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410485438.jpg"> +4 <br>images </div> </div> </div> </li> </ul> </div> <div class="col-md-10 border rounded d-flex align-items-center justify-content-center product-image-lightbox"> <div class="text-center my-2" data-brand="rnd"> <img src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Western_Blot_12633.jpg" alt="Detection of Human IL-17 antibody by Western Blot." title="Detection of Human IL‑17 by Western Blot." data-caption="Western blot shows lysates of human primary naïve CD4<sup>+</sup> T cells, along with whole cell lysates (WCL) and conditioned-media supernatant (Supe) of human primary differentiated Th17 cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf017" target="_self">HAF017</a>). A specific band was detected for IL-17 at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." data-badges='' data-id="0" width="250" height="250" fetchpriority="high" as="image" class="search_result_thumbnail_image active" /> </div> </div> </div> </div> </div> <div class="col-xl-6 mt-2" id="orderdetails-wrapper" data-section="order_detail_block"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="AF-317-NA"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 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</div> <div class="commerce-atc-conjugates-formulations-productline mt-2 border-top" data-catalog="BAF317" data-titleoverwrite="Biotin"> <div class="row my-2 mx-0"> <div class="col-8 my-auto"> <div class="row"> <div class="commerce-atc-catnum col-12 col-md-6 p-0 font-weight-bold"> <a href="/p/antibodies/human-primate-il-17-il-17a-biotinylated-antibody_baf317">Biotin</a> </div> <div class="commerce-atc-price col-12 col-md-6 p-0"> <a href="/p/antibodies/human-primate-il-17-il-17a-biotinylated-antibody_baf317">BAF317</a> </div> </div> </div> <div class="commerce-atc-atc-btn col-4 p-0"> <a type="button" href="/p/antibodies/human-primate-il-17-il-17a-biotinylated-antibody_baf317" class="btn button--primary col-xs-4 order-last btn-md-block w-100 p-1"> View Product </a> </div> </div> </div> </div> </div> </div> </div> </div> <div id="guarantee-statement" class="text-right" data-section="section-base--guarantee-statement"> <span class="icon-icon-check-circle"></span> <a href="/guarantee">100% 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text-break"> Biological Validation </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Species Reactivity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <h4 class="d-block">Validated:</h4> <div class="d-block pb-2"> Human </div> <h4 class="d-block">Cited:</h4> <div class="d-block pb-2"> Human, Mouse, Canine </div> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Applications</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <h4 class="d-block">Validated:</h4> <div class="d-block pb-2"> CyTOF-ready, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Intracellular Staining by Flow Cytometry, Neutralization, Western Blot </div> <h4 class="d-block">Cited:</h4> <div class="d-block pb-2"> Cell Culture, ELISA Development, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Neutralization, Tissue Culture, Western Blot </div> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Label</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Unconjugated </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Antibody Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Polyclonal Goat IgG </div> </div> </div> <div class="container"> <div class="row product-data"> <div class="col-lg-6 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4><a href="/t/il-17-il-17a/antibodies">View all IL-17/IL-17A Antibodies »</a></h4> </div> </div> </div> </div> <div class="border-top border-bottom recommended-products-section" id="recommendation-viewed" data-product_code="AF-317-NA" data-type=viewed></div> <div id="product-specifications" class="bt-pp-border-bottom py-5" data-section="section-base--product-specifications"> <h3>Product Specifications</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Immunogen</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <EM>E. coli</EM>-derived recombinant human IL-17<br />Ile20-Ala155<br />Accession # Q16552 </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Specificity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Detects human IL-17 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant canine IL-17 is observed. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Clonality</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Polyclonal </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Goat </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Isotype</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> IgG </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Endotoxin Level</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.10 EU per 1 μg of the antibody by the LAL method. </div> </div> </div> </div> <div id="scientific-data" class="bt-pp-border-bottom py-5" data-anchor-label="Scientific Data" data-section="section-base--scientific-data"> <div> <h3>Scientific Data Images for Human IL-17/IL-17A Antibody </h3> </div> <div class="product-data-wrapper mt-5" id="scientific-data-table" data-scientific-count="5"> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Western_Blot_12633.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Western_Blot_12633.jpg" alt="Detection of Human IL-17 antibody by Western Blot." title="Detection of Human IL‑17 by Western Blot." data-caption="Western blot shows lysates of human primary naïve CD4<sup>+</sup> T cells, along with whole cell lysates (WCL) and conditioned-media supernatant (Supe) of human primary differentiated Th17 cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf017" target="_self">HAF017</a>). A specific band was detected for IL-17 at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." data-badges="" data-application="Western Blot" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Detection of Human IL‑17 by Western Blot.</h4> Western blot shows lysates of human primary naïve CD4<sup>+</sup> T cells, along with whole cell lysates (WCL) and conditioned-media supernatant (Supe) of human primary differentiated Th17 cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a href="/p/secondary-antibodies/goat-igg-hrp-conjugated-antibody_haf017" target="_self">HAF017</a>). A specific band was detected for IL-17 at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL17_AF317NA_Immunohistochemistry_20615.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL17_AF317NA_Immunohistochemistry_20615.jpg" alt="IL-17/IL-17A antibody in Human Tonsil by Immunohistochemistry (IHC-P)." title="IL‑17/IL‑17A in Human Tonsil." data-caption="IL-17/IL-17A was detected in immersion fixed paraffin-embedded sections of human tonsil using Goat Anti-Human IL-17/IL-17A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (<a href="/p/secondary-antibodies/goat-igg-visucyte-hrp-polymer_vc004" target="_self">VC004</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." data-badges="" data-application="Immunohistochemistry" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">IL‑17/IL‑17A in Human Tonsil.</h4> IL-17/IL-17A was detected in immersion fixed paraffin-embedded sections of human tonsil using Goat Anti-Human IL-17/IL-17A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (<a href="/p/secondary-antibodies/goat-igg-visucyte-hrp-polymer_vc004" target="_self">VC004</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Immunoprecipitation_12634.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Immunoprecipitation_12634.jpg" alt="Immunoprecipitation of Human IL‑17." title="Immunoprecipitation of Human IL‑17." data-caption="Human IL-17 was immunoprecipitated from 100 µg of human primary differentiated Th17 cell lysate following incubation with 3 µg Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) or control antibody (<a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>) overnight at 4 °C. IL-17-antibody complexes were absorbed using Protein G Sepharose. Immunoprecipitated IL-17 was detected by Western blot using 1 µg/mL Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA). View our recommended buffer recipes for immunoprecipitation." data-badges="" data-application="Immunoprecipitation" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Immunoprecipitation of Human IL‑17.</h4> Human IL-17 was immunoprecipitated from 100 µg of human primary differentiated Th17 cell lysate following incubation with 3 µg Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA) or control antibody (<a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>) overnight at 4 °C. IL-17-antibody complexes were absorbed using Protein G Sepharose. Immunoprecipitated IL-17 was detected by Western blot using 1 µg/mL Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA). View our recommended buffer recipes for immunoprecipitation. </div> </div> </div> <span class="product-data-wrapper table" id="more-scientific-data" style="display:none"> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Flow_Cytometry_3414.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Flow_Cytometry_3414.jpg" alt="Detection of IL-17 antibody in Human PBMCs antibody by Flow Cytometry." title="Detection of IL‑17 in Human PBMCs by Flow Cytometry." data-caption="Human peripheral blood mononuclear cells were unstimulated (light orange filled histogram) or treated with 50 ng/mL PMA and 250 ng/mL Ca <sup>2+</sup>ionomycin for 16 hours, then stained with Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA, dark orange filled histogram) or isotype control antibody (<a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (<a href="/p/secondary-antibodies/goat-igg-h-l-apc-conjugated-antibody_f0108" target="_self">F0108</a>). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin." data-badges="<span class="biological-validation"></span>" data-application="Intracellular Staining by Flow Cytometry" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <div class="validation-badges-header-wrapper"> <a class="biological-validation mr-3 d-inline-flex mt-1" href="/reagents/antibodies/antibody-validation" target="_blank" title="Biological Validation"></a> </div> <h4 class="font-weight-bold">Detection of IL‑17 in Human PBMCs by Flow Cytometry.</h4> Human peripheral blood mononuclear cells were unstimulated (light orange filled histogram) or treated with 50 ng/mL PMA and 250 ng/mL Ca <sup>2+</sup>ionomycin for 16 hours, then stained with Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA, dark orange filled histogram) or isotype control antibody (<a href="/p/isotype-controls/normal-goat-igg-control_ab-108-c" target="_self">AB-108-C</a>, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (<a href="/p/secondary-antibodies/goat-igg-h-l-apc-conjugated-antibody_f0108" target="_self">F0108</a>). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Block_Neutralize_8693.jpg" data-srcset="https://resources.bio-techne.com/images/products/antibody/IL-17_AF-317-NA_Block_Neutralize_8693.jpg" alt="IL-6 Secretion Induced by IL-17 and Neutralization by Human IL-17 Antibody." title="IL‑6 Secretion Induced by IL‑17 and Neutralization by Human IL‑17 Antibody." data-caption="Recombinant Human IL-17 (<a href="/p/proteins-enzymes/recombinant-human-il-17a-protein-cf_317-ilb" target="_self">317-ILB</a>) stimulates IL-6 secretion in NIH/3T3 mouse embryonic fibroblasts in a dose-dependent manner (orange line), as measured by the mouse IL-6 Quantikine ELISA Kit (Catalog # M6000B). IL-6 secretion elicited by Recombinant Human IL-17 (15 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA). The ND<sub>50</sub> is typically 0.02-0.12 µg/mL." data-badges="" data-application="Neutralization" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">IL‑6 Secretion Induced by IL‑17 and Neutralization by Human IL‑17 Antibody.</h4> Recombinant Human IL-17 (<a href="/p/proteins-enzymes/recombinant-human-il-17a-protein-cf_317-ilb" target="_self">317-ILB</a>) stimulates IL-6 secretion in NIH/3T3 mouse embryonic fibroblasts in a dose-dependent manner (orange line), as measured by the mouse IL-6 Quantikine ELISA Kit (Catalog # M6000B). IL-6 secretion elicited by Recombinant Human IL-17 (15 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-317-NA). The ND<sub>50</sub> is typically 0.02-0.12 µg/mL. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410485438.jpg" data-srcset="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410485438.jpg" alt="Detection of Human IL-17/IL-17A by Immunohistochemistry" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Expression of psoriasis‐related cytokines in paradoxical psoriasiform reactions. Immunohistochemistry analysis performed on paradoxical skin lesions obtained from patients 1 (Pt1) and 2 (Pt2) shows similar values of IL‐17A+ cells, a reduction of dermal IFN‐ gamma+ cells and an increase of IL‐22+ or IL‐36 gamma+ cells, when compared with psoriatic skin lesions. LS and NLS skin of the same psoriatic patient (n = 3) was analyzed. Graphs show the mean of number of positive cells + SD per three sections. One out of three representative stainings is shown. *p < 0.01, **p < 0.05, versus classical psoriasis. Scale bars, 200 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31577850), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Immunohistochemistry" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Detection of Human IL-17/IL-17A by Immunohistochemistry</h4> Expression of psoriasis‐related cytokines in paradoxical psoriasiform reactions. Immunohistochemistry analysis performed on paradoxical skin lesions obtained from patients 1 (Pt1) and 2 (Pt2) shows similar values of IL‐17A+ cells, a reduction of dermal IFN‐ gamma+ cells and an increase of IL‐22+ or IL‐36 gamma+ cells, when compared with psoriatic skin lesions. LS and NLS skin of the same psoriatic patient (n = 3) was analyzed. Graphs show the mean of number of positive cells + SD per three sections. One out of three representative stainings is shown. *p < 0.01, **p < 0.05, versus classical psoriasis. Scale bars, 200 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31577850), licensed under a CC-BY license. Not internally tested by R&D Systems. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410481145.jpg" data-srcset="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410481145.jpg" alt="Detection of Human IL-17/IL-17A by Immunohistochemistry" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Inflammatory cell infiltrates of early acne lesions in immunohistochemistry.Representative immunohistochemical staining showing IL-17A+ cells in early acne lesion (a). Staining of IL-17A+ and CD3+ cells shows that IL-17A (in green) and CD3 (in red) were detected in acne vulgaris lesions. Cell nuclei were counterstained in blue. Arrows indicate IL-17A and CD3 double positive cells (b). T-bet+ cells (c) were more numerous than IL-17A+ cells or Foxp3+ cells (d) in the lesional acne skin. Large number of CD4+ cells (e), mostly lymphocytes, was seen around pilosebaceous unit and perivascularly. CD8+ cells (f) were fewer in number than CD4+ cells. Large number of CD68+ macrophages (g) and a few CD83+ cells (h), which are mature dendritic cells, were detected around sebaceous follicles. (Bar = 200 µm; in the insets bar = 50 µm). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25153527), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Immunohistochemistry" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Detection of Human IL-17/IL-17A by Immunohistochemistry</h4> Inflammatory cell infiltrates of early acne lesions in immunohistochemistry.Representative immunohistochemical staining showing IL-17A+ cells in early acne lesion (a). Staining of IL-17A+ and CD3+ cells shows that IL-17A (in green) and CD3 (in red) were detected in acne vulgaris lesions. Cell nuclei were counterstained in blue. Arrows indicate IL-17A and CD3 double positive cells (b). T-bet+ cells (c) were more numerous than IL-17A+ cells or Foxp3+ cells (d) in the lesional acne skin. Large number of CD4+ cells (e), mostly lymphocytes, was seen around pilosebaceous unit and perivascularly. CD8+ cells (f) were fewer in number than CD4+ cells. Large number of CD68+ macrophages (g) and a few CD83+ cells (h), which are mature dendritic cells, were detected around sebaceous follicles. (Bar = 200 µm; in the insets bar = 50 µm). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25153527), licensed under a CC-BY license. Not internally tested by R&D Systems. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410484368.jpg" data-srcset="https://resources.bio-techne.com/images/products/af-317-na_human-il-17-affinity-purified-polyclonal-ab-41202410484368.jpg" alt="Detection of Human IL-17/IL-17A by Immunohistochemistry" title="Detection of Human IL-17/IL-17A by Immunohistochemistry" data-caption="Inflammatory cell infiltrates of early acne lesions in immunohistochemistry.Representative immunohistochemical staining showing IL-17A+ cells in early acne lesion (a). Staining of IL-17A+ and CD3+ cells shows that IL-17A (in green) and CD3 (in red) were detected in acne vulgaris lesions. Cell nuclei were counterstained in blue. Arrows indicate IL-17A and CD3 double positive cells (b). T-bet+ cells (c) were more numerous than IL-17A+ cells or Foxp3+ cells (d) in the lesional acne skin. Large number of CD4+ cells (e), mostly lymphocytes, was seen around pilosebaceous unit and perivascularly. CD8+ cells (f) were fewer in number than CD4+ cells. Large number of CD68+ macrophages (g) and a few CD83+ cells (h), which are mature dendritic cells, were detected around sebaceous follicles. (Bar = 200 µm; in the insets bar = 50 µm). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25153527), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Immunohistochemistry" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Detection of Human IL-17/IL-17A by Immunohistochemistry</h4> Inflammatory cell infiltrates of early acne lesions in immunohistochemistry.Representative immunohistochemical staining showing IL-17A+ cells in early acne lesion (a). Staining of IL-17A+ and CD3+ cells shows that IL-17A (in green) and CD3 (in red) were detected in acne vulgaris lesions. Cell nuclei were counterstained in blue. Arrows indicate IL-17A and CD3 double positive cells (b). T-bet+ cells (c) were more numerous than IL-17A+ cells or Foxp3+ cells (d) in the lesional acne skin. Large number of CD4+ cells (e), mostly lymphocytes, was seen around pilosebaceous unit and perivascularly. CD8+ cells (f) were fewer in number than CD4+ cells. Large number of CD68+ macrophages (g) and a few CD83+ cells (h), which are mature dendritic cells, were detected around sebaceous follicles. (Bar = 200 µm; in the insets bar = 50 µm). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25153527), licensed under a CC-BY license. Not internally tested by R&D Systems. </div> </div> </span> <div class="row"> <div class="col-md-2"> <a id="scientific-view-more" class="more"> View 5 more images </a> </div> </div> </div> </div> <div id="applications" class="py-5 bt-pp-border-bottom" data-anchor-label="Applications" data-section="section-antibody--applications"> <h3>Applications for Human IL-17/IL-17A Antibody </h3> <div class="mt-5 py-2 container"> <div class="row"> <div class="col-lg-3 border font-weight-bold text-bg-dark py-2 align-top text-md-left text-white bg-dark-bt-blue d-none d-lg-block"> Application </div> <div class="col-lg-9 border align-top py-2 font-weight-bold text-white bg-dark-bt-blue d-none d-lg-block"> Recommended Usage </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>CyTOF-ready</h4> </div> <div class="col-lg-9 border align-top py-2"> Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Immunocytochemistry</h4> </div> <div class="col-lg-9 border align-top py-2"> 5-15 µg/mL <br/>Sample: Immersion fixed human peripheral blood mononuclear cells treated with PHA </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Immunohistochemistry</h4> </div> <div class="col-lg-9 border align-top py-2"> 1-15 µg/mL <br/>Sample: Immersion fixed paraffin-embedded sections of human tonsil </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Immunoprecipitation</h4> </div> <div class="col-lg-9 border align-top py-2"> 3 µg/100 µg cell lysate <br/>Sample: Human primary differentiated Th17 cells </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Intracellular Staining by Flow Cytometry</h4> </div> <div class="col-lg-9 border align-top py-2"> 2.5 µg/10<sup>6</sup> cells <br/>Sample: Human peripheral blood mononuclear cells treated with PMA and Ca<sup>2+</sup> ionomycin, fixed with paraformaldehyde, and permeabilized with saponin </div> </div> <div class="row"> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Western Blot</h4> </div> <div class="col-lg-9 border align-top py-2"> 1 µg/mL <br/>Sample: Human primary naïve CD4<sup>+</sup> T cells and human primary differentiated Th17 cells </div> </div> <div class="row"> <div class="col-lg-3 border font-weight-bold product-data-label py-2 align-top text-md-left text-break"> <h4>Neutralization</h4> </div> <div class="col-lg-9 border align-top py-2"> Measured by its ability to neutralize IL‑17-induced IL‑6 secretion in NIH/3T3 mouse embryonic fibroblasts. Yao, Z. <em>et al</em>. (1995) Immunity <strong>3</strong>:811. The Neutralization Dose (ND<sub>50</sub>) is typically 0.02-0.12 µg/mL in the presence of 15 ng/mL Recombinant Human IL‑17. </div> </div> </div> <div class="product-data-wrapper mt-5"> Please Note: Optimal dilutions of this antibody should be experimentally determined. </div> <h4 class="mt-3">Reviewed Applications</h4> <p><span class="review_stars review_stars_4"></span> Read <a href="#reviews" class="reviews">9 reviews</a> rated 4.2 using AF-317-NA in the following applications:</p> <ul class="list-unstyled"> <li><a href="#reviews" class="reviews" data-application="Block/Neutralize">Block/Neutralize (1 Review) </a></li> <li><a href="#reviews" class="reviews" data-application="Immunocytochemistry">Immunocytochemistry (2 Reviews) </a></li> <li><a href="#reviews" class="reviews" data-application="Immunohistochemistry">Immunohistochemistry (3 Reviews) </a></li> <li><a href="#reviews" class="reviews" data-application="Immunohistochemistry-Paraffin">Immunohistochemistry-Paraffin (2 Reviews) </a></li> </ul> </div> <div id="preparation--storage" class="bt-pp-border-bottom py-5" data-section="section-base--preparation-storage"> <h3>Formulation, Preparation, and Storage</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Purification</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Antigen Affinity-purified </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Reconstitution</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <div class="atc-container"> <div class="commerce-atc-reconstitution atc-block" data-type="reconstitution" data-blockid="ReconstitutionCart"> <div class="commerce-atc-reconstitution__instructions"> Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration. </div> <p class="atc-modal"></p> <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode=""> <div class="commerce-atc-reconstitution-header atc-header col-four row border-top pt-2 m-0"> <div class="commerce-atc-catnum atc-head col-md-6 font-weight-bold p-0">Reconstitution Buffer Available:</div> <div class="commerce-atc-price atc-head col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-md-3 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ReconstitutionCart" class="atc-lines"> <div class="commerce-atc-reconstitution-line productline col-four row py-2 m-0" data-catalog="RB01"> <div class="commerce-atc-title col-md-6 p-0"> <a href="">RB01: </a> </div> <div class="commerce-atc-price col-md-3"> </div> <div class="commerce-atc-quantity col-md-3 text-right p-0"> </div> </div> </div> <div class="atc-control ReconstitutionCart-control text-right mt-2"> <input type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc col-xs-4"/> </div> </div> </form> </div> </div> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Formulation</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Shipping</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Stability & Storage</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>6 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL> </div> </div> </div> </div> <div id="background" class="py-5 bt-pp-border-bottom" data-section="section-base--background-info"> <h3>Background: IL-17/IL-17A</h3> <article class="product-data-wrapper"> <P>Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Human IL-17 cDNA encodes a 155 amino acid (aa) residue precursor protein with a 19 amino acid residue signal peptide that is cleaved to yield the 136 aa residue mature IL-17 containing one potential N-linked glycosylation site. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. At the amino acid level, human IL-17 shows 72% and 63% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has recently been cloned. While the expression of IL-17 mRNA is restricted to activated T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappa B and costimulation of T cell proliferation. </P> </article> <div id="background_wrapper" class="px-3 mt-2"> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Long Name</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> Interleukin 17 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Alternate Names</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> CTLA-8, CTLA8, IL-17A, IL17, IL17A </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Entrez Gene IDs</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.ncbi.nlm.nih.gov/gene?term=3605" class="a___link-external" target="_blank" rel="nofollow">3605</a> (Human); <a href="https://www.ncbi.nlm.nih.gov/gene?term=16171" class="a___link-external" target="_blank" rel="nofollow">16171</a> (Mouse); <a href="https://www.ncbi.nlm.nih.gov/gene?term=301289" class="a___link-external" target="_blank" rel="nofollow">301289</a> (Rat); <a href="https://www.ncbi.nlm.nih.gov/gene?term=449530" class="a___link-external" target="_blank" rel="nofollow">449530</a> (Porcine); <a href="https://www.ncbi.nlm.nih.gov/gene?term=481837" class="a___link-external" target="_blank" rel="nofollow">481837</a> (Canine); <a href="https://www.ncbi.nlm.nih.gov/gene?term=102119976" class="a___link-external" target="_blank" rel="nofollow">102119976</a> (Cynomolgus Monkey) </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Gene Symbol</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> IL17A </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>UniProt</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.uniprot.org/uniprot/?query=Q16552" class="a___link-external" target="_blank" rel="nofollow">Q16552</a> </div> </div> </div> <h4 class="mt-3">Additional IL-17/IL-17A Products</h4> <ul class="list-unstyled"> <li><a href="/t/il-17-il-17a" data-product="IL-17/IL-17A">All Products for IL-17/IL-17A </a></li> <li><a href="/t/il-17-il-17a/cdna-clones" data-application="IL-17/IL-17A cDNA Clones">IL-17/IL-17A cDNA Clones </a></li> <li><a href="/t/il-17-il-17a/elisa-kits" data-application="IL-17/IL-17A ELISA Kits">IL-17/IL-17A ELISA Kits </a></li> <li><a href="/t/il-17-il-17a/elispot-fluorospot-kits" data-application="IL-17/IL-17A ELISpot and FluoroSpot 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