CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '91399b16ca7bf888',cH: 't0yNPDXOcYKgDU_Giem2FZbqUmr49pXFhgx.TgEeISI-1739835451-1.2.1.1-M1SxRhdn1eXIqxocNWCxQplJXrtIl6zYNVSExG5KNUIzDE9FETbICE1ta0ozdejj',cUPMDTk: "\/doi\/10.1021\/cr990050q?__cf_chl_tk=EJqaKdQf8tYbMjV1FABayfTeFRFtviUFbCTxmf7KEFI-1739835451-1.0.1.1-uQ9mrLtRygSGGDHXPNF_zk2u6lzYbKz4Djvmhr9R5cE",cFPWv: 'g',cITimeS: '1739835451',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/cr990050q?__cf_chl_f_tk=EJqaKdQf8tYbMjV1FABayfTeFRFtviUFbCTxmf7KEFI-1739835451-1.0.1.1-uQ9mrLtRygSGGDHXPNF_zk2u6lzYbKz4Djvmhr9R5cE",md: "vo4l_6eOIzzpNYZThbyirDMwAD8faxszWGM__pFVa38-1739835451-1.2.1.1-9Z1mdflA9LCL7F3VSaw.7kjRNsLxAj9I8lOVdwBhjMltSWPstrhtNH7LGaamPfxQztkH17AIlGWW9kssPcJF2Wgj1.16nDkoe_4Yt3oBv4QksT5DMYlo1p6yN..0Hb3q1E7fv0ok7AE.kRunVbBSBURJst_bf7DYE5dclg5UrMLtkQIKZIYjuxg8RXo2vypC02JIT_KcWPVd0EGlaFB0rJ3814UpuLn0TsfTh2ElDTJB9i_NwVhoYxRzhsdkeWX0jsWtkbyKd7wYC66tVa.IxQgYBpeL5TOUeATPXaDx0H9C0fSgfggkP7fmMrVuRo9OjgjXolHXGvqvoZWPlOVLz2bK3cWyXiowJkyft_ElWo3qPi6sFSPqNhSKjknqq49sh6YaQ9.xcaaM3gIEH3oGGTjrvO4ozi00szmqIdk0fj3dQcKJ64eNrMJeKvm9ctnX_krIjQ8ytrhiwDrGnKURgtIl7C3Pu8mQeK9._bCHTmjHol_ZYnzempwdM9Ji927NA7HUIYq.efQ.amlPyWinVrUzIEu5I.M7fC3jaOi_ZyNL2o0hROkpVheSpIeFBEHa6Bw7ByGUqphS1VOQb_6XWhgtVyZ_36ConvGv8JSN9gUC9qUddTvlkPg21ZlMiZqns_ZJ34Xr0iJ2k5eh1kiadbYX.sAl56zj0G2vfQ31QqM8LEV_ASV6b6FF32WkjvZBM9jcMquLW5WwlrlZUl3Hdq3oOZSRu7SyOA6wKfuyUtEsxdIbYZ9sQE6ejr4MA0BZugLQHpU8DNyHNWJEfTiWS4FlYUrS3cV3KjyyvbbEvQbxEWPEiB3TDFHGXGNUfX_g1krUxdad03K3Qe89GjBZUoTAesirYGSgQCUCeHg62vCU.E._PXvq9yn6XG7bqwivuWmUru_a0TJ3NMJXfzWmp59lCh1FSkBcIrQDEPxvfPHPdW9vUiMth7Th5xW.QzIkqseUJvCyj7bFHXxag05nAk9yUcHcH5DP4jo4tRXH9CWaD.SNOTGw3WwdrLYIQGxLv3Tmy4bSbMG2mziLn5g3J5fuEVl8dmdKw11F06dkJmW87GlrBXWhMAO3I1iom6npUu565vBre1KgSQq7dz_lqVjaSsxA2e0cFfJyyMWuTEJaynwSMYHtkh4ZyD.pOTrhCnP6qDd64V1ofkK4KQPvcpu9XNvE7cEf4FWnwFA6VS2u4W4z2ZC1wOoRshtTtOQSK_GQg9lWyY.U6FF9ZzXjCe30ql2GTftiO9g4Lrn_Wi1KGUY71Wwqp8yYRo8VWIr58oBz8WfH8y2YcQafXR0G0Aug6BKBrxtPjYVqVc1lQ65E7LPZgC.y2ibk8t1CprkH1YvtMXmjDWHvWs651A.fC2rJqU8hw1k9adWyDhiN05Jsz5G1eX5dEmClPGUAmUxDgK4RQc72O6zsaLMyLRawe5xYxEwwBNAB1krx0CKdop2_RNMckC9OnbarldXy_TLlyiDnHPFkS35qq9n5he6HJqmAywEEe67_cIHaB._KnI3v3LtZVWxScsOcAjw5QImFTMYhTkTdxFkxYPSjxGa.bPVTcHYKoC.ncdt35XFZHzuNw28GSq8LbXA5nU.PYfn9YA4qxaEZilMVrTOHYKb.pUYYVQXAf8Dv96aXRstWUsYqQFQi2JbXQ8KOdJD02IT1d7BPruHBXxSBP25Q6ypqJOqO9l.EIZKuL_Ep.Q70L1ibXhAbkXE_GbQhOsUotvOt3pd3ZPjopeNh4Ydtrf.H87oejeSkNaRYg67wahUcYKyyvQ.4.cwEYb4Ojd93wvMZSDWVYxKOAaKULLXImKfWheoiT6kGGvnXNJr8HlmrrGiFS_YkHDmmiYt_72xD15rwX0wB6IfWOwo6yfW4HAKdOn4JReZ7Ft51V78ZBkthNg_eeYSGdkFJD2hs8mW6_Dnr0DPxCf.lObqpGOTLvOCO.kif4xtvxcXXhhTvC5W4TlWLR4JkwNJoorFI3m1cUHcUef3Donc1K6Ak71aWrUgFvgaSw9rcp88dL0QmO7vv06SMy6gagXnQYCRfdCrgDqY0Y.tMcfdsb2SxrbiFurC0DCB68tphNXZyHu2eEv0r_jDy40Tqre6sa2DtSDmeIWSELtmNM.rRUtoDqMsmVA.uIW3CFdRAWJxJjKyioStQU5fH4CkLrLAIUH_Na2iPRhUxup4lA.nxcEO0l1Dlg4pFaUsxsFm4Dx_XaaXOEwcA.QV9rjf_CbVkt0rOFAPS5aBFPrckEhZJKqXN6QhguqV_qveA0ZoWj2kAFgQT_Gj68vJuxshHFMYMtbM_1TA4JdHiOgkfNUrky5UXrS7zXKT0dJ380iQSJOST.5rshPKoWKJaXAmhmsZIhpwN3Unuhjp91tLptdT8eNQ6cU542e1_AXA7s09YX4AdcyJ8OioRH1gWmOzvwwdwJzkS24oIY_nuihlzYjcryT79zzkMPy0A8hUC4PYfIyqZdk3F3m6hv_DbB49dwOwAjOlkAQ83B462iNbvZWm4mWComknUCsyLb9_TDCr..E1.CgIRujr5pVR0P1SwLizjmvsuwo4U8efR",mdrd: "yoxAWhJ7ZlhG73OiEQKnGFF5Ytp9NwRk6cbcd9x0_vM-1739835451-1.2.1.1-.pvVYJvf9cVfUMHgkNCD1dWFuC5CHfJ1yMpSMT3fSI5CRrvWlGiYB9rjCoGCllxxP8u6xVjZBoffntRDVz8QkFbjD_dhjg5bQ6UsQhwKJQ9Ryh1fIjbuAWqUd2kobeM0qNUq9ITKRN_S1Lw54NAUmy468KgrOXRANaRRMTM._0Dcn9LbLAqJ7Qrgq12jqi0UTgKQCP4xDQEMHdIGECjByLM9f7PhKwu786YYpy9Nvun0sXH7pYKZiEmroDSc8raDhMRkZwv0X9PkZHh8jbIQg_m0qRCn0qz1qBKZw8Wm4TUYKUoB2an1rP46Mf2jomfTncJtpwppEccrcph0FjSW3RS4yIyRk0y7pTBy2cxL1SdPp07Hn__z9DIJsOvwiXO_yw2BTMPppe_FG1DlXoEQKasDlpel4izhTzPplmV_Pv8__wvKLHpziGnr7SzAaNKP20NpOfqi8laicdQhVdgztEF5lXB4Fhmj61.djCWkD5CaEBBKL3rXVB3FmwJKpYfxl.1zLB_84llHYqccQJ8t2m2kuTSu5ETPuaPoFNOdn8WdqrukhFbTR0JO5BPZPJCWpiA18eNIzT3CIDivEiElqg9pvU3V3KeRE12cgU7PJjnJiKT10N9lJ2s8E.HVkNiTXvk0bbvudj.8Vl5Gx7orF8OufARTQwvTVNgITS604N_fBfZ82ZVO00QHw_HJlfGgEdgusc_lXiaOvfCLzLJQlPcgIJfgw3n4CQi2QuBg49vzJV.I32dQAdCxphWrOAJ6yvuWD4ARLxnllFzjLyIvpD.Hp5ZbDbK14FGFDm0mmF1x.s6SK2NOmL3Z2bnFzQEqhnLHEqMzn5zUxmVHyyaCNfmMkABN.RDE2gZ5VmdZUXHIU0y5LAjgSxPaOranaDZvw_ejpIDLSlfmRbEbyeVDNfKhreJdJJq0WeAjh2AgB21nJ5L0nTKJCPBMG6Vg7F2Zh8o.aszyMSSPl8dsTgPOoa7y0.43TwWb7nODcvQ4A.b7J18WJuuvY94LRVIzZZOP4F4fwzPXW5aLXrxfSTjoQBpSeg1P8y6xnFPLDJ.T5J9W6D3F2chYLVSE_qAZuWeePLKc8VjSxcc6K3d2zdYLkQSIs08zZ._JwgXj_MA1smyvGRI8yaFaWtV8StpBWcEeIfaX0DR_pmSzf0WYkQPUR30tQLH38Y6lOKwav82dfE1siz39MLjtum83A5G6StdBQubNyFRizXJswJPXqn7tHB2JfVzWgZ38NgMxF5EW5DU1P6rIeA6q5fdWdu93v8lBQCYv0.qUVIz2W2Vnu3qASx3vu6ryqTsbA_86ztYTIkt98Iv6m5L8QBAyH4SaBF6LNbPtUq4G32yc5VycaHC2O.Mt1oyH5but9wLPhBma0JpK6UCDGKZ.TvytmHARLBaMmAvvbUJ1jQ7KVDjXlhs3Q8lI_0IWXGARtk6QlpnorL3GQrzHOi53Y8qkR3zH_cRnR1Klju_8JvVeGPQ6HKslrxtQhZ3RP4fMQjiNMoJqo17Pd5_RPFrMt1xYIKCextjQk0yYdUWuPuY34xXhHlot69KmsE95JutElVgqEvNzJr.1uK.InZ9vDBUrLdAPStvqWCW7aeVaXGHg3QvCQq2ehEvJZCe0cN64E_uYF0jxowtECy1W3AVJt35DPgiJE5CBmGOcqcnalF4ISJZ6TCMPZN21Lv5lqWq6IdQ1EXshv8JtFBcdyre0ozQF7ZDaR5KSFT34QixRYl91KWZ2O8GmBfXz3rpZ1bKWy.g50.qtzgLjsXucSGOKEdQeA_7mEqO2UQTJfpPyKuSzHyrExOOT.5CvonBerjQu9KpdOBhEynGzA_KQoWjRM8daiKh6CMrxCEn2WoiGEpOBIN7DDvp83r5pzPtSGCaClRc6jEOc9_kAq43waCle2DHPssRmvvkfxcxKJ5Uqh1k9pwU2Bu.v4vfYMtH4b6L1XBMsOTcOpBY"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=91399b16ca7bf888';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/cr990050q?__cf_chl_rt_tk=EJqaKdQf8tYbMjV1FABayfTeFRFtviUFbCTxmf7KEFI-1739835451-1.0.1.1-uQ9mrLtRygSGGDHXPNF_zk2u6lzYbKz4Djvmhr9R5cE" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>