CINXE.COM

Software to Predict Toxicity | Safety Endpoints Calculator | Tox Suite | ACD/Labs

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} body .comments-area .comment-metadata * { font-size: 0.8rem; } body .comments-area .comment-content p, body .comments-area .comment-content a { font-size: 1rem; color: #0a0a0a; } body .comments-area .comment .comment-body { background-color: #eeeeee; border-radius: 15px; padding: 15px; } body #reply-title { font-size: 1.5rem; color: #2278b0; } body .comments-area .comment-author .fn, body .comments-area .comment-author .fn a { font-size: 1rem; pointer-events: none; text-decoration: none; } body #gform_fields_41 .gfield_label_before_complex { display: block !important; } /* DISCLAIMER for Portal Pages*/ .disclaimer { padding: 40px 0; background-color: #6a6ef4; color: #ffffff; } .disclaimer .link-container { display: flex; align-items: center; justify-content: center; flex-wrap: wrap; } /* 5050 Block with larger text area */ .content-5050-large { position: relative; z-index: 1; padding: 60px 20px; max-width: 700px; } .content-5050-large h3 { font-size: 28px; line-height: 36px; } /* lighten parent page label in hero */ body.page-template-product-child-page .site-hero .badge, body.page-template-product-database-page .site-hero .badge { background: rgba(106, 110, 245, 0.25); } /* prevent svg icon blending with active background */ body .vertical.tabs .tabs-title.is-active img.icon { background: #fff; border-radius: 50%; box-shadow: 0 0 0 2px #0068a6; } body.is-mobile .hero__background-video { display: none !important; } body.is-mobile.home .hero.hero--advanced:before { background: linear-gradient(332deg, #001d2e 10.11%, #00314e 93.63%); } /* Remove bottom padding on pages w/ multi-line supported logos */ .supported-logos-multi-row { padding-top: 40px; padding-bottom: 0px; } /*Remove load More on Symposium*/ .agenda-block { height: auto !important; } .agenda-block .symposium-agenda-loadmore { display: none !important; } /* Slider dots sit below images on product pages */ @media screen and (min-width: 1200px) { .views-slider-container .slick-dots { bottom: auto; } } /*Style drop-down fields like text boxes */ .gfield_select { background-color: #ffffff; border: 1px solid #8baed4; } /* Remove padding from cards for Resource pages */ @media print, screen and (min-width: 64em) { .flexible-page-cards-no-padding { padding: 30px 0; } } .flexible-page-cards-no-padding { padding: 30px 0; } .flexible-page-cards-no-padding .card-row { display: flex; align-items: center; justify-content: center; } .flexible-page-cards-no-padding .card-row .main-link { display: inline-block; max-width: 441px; } .flexible-page-cards-no-padding a { text-decoration: none; font-weight: initial; } @media print, screen and (min-width: 40em) { .flexible-page-cards-no-padding .card { height: 100%; margin-left: 12px; margin-right: 12px; } } @media screen and (max-width: 39.99875em) { .flexible-page-cards-no-padding .card-row { flex-wrap: wrap; } .flexible-page-cards-no-padding .card { width: 100%; height: auto; margin-bottom: 16px; } } .flexible-page-cards-no-padding .card { background: #fff; margin-bottom: 22px; padding: 40px 30px; border: solid 1px #6a6ef4; display: flex; flex-direction: column; align-items: flex-start; justify-content: center; box-shadow: 0px 10px 24px rgb(106 110 244 / 15%); } .flexible-page-cards-no-padding h4 { color: #0067a6; } .flexible-page-cards-no-padding .card p { font-size: 16px; line-height: 25px; letter-spacing: 0.5px; color: #767676; } /* Supported Logos Multi-Row (use this for all except the bottom row)*/ .page-template-product-child-page .supported-logos-multi-row, .page-template-product-database-page .supported-logos-multi-row { padding-top: 40px; padding-bottom: 0px; } .page-template-product-child-page .supported-logos-multi-row .logos, .page-template-product-database-page .supported-logos-multi-row .logos { list-style: none; max-width: 1000px; margin-left: auto; margin-right: auto; display: flex; align-items: center; justify-content: center; flex-wrap: wrap; } .page-template-product-child-page .supported-logos-multi-row .logos li, .page-template-product-database-page .supported-logos-multi-row .logos li { width: 100px; margin: 15px; } .page-template-product-child-page .supported-logos-multi-row .link-container, .page-template-product-database-page .supported-logos-multi-row .link-container { margin-top: 20px; } .page-template-product-child-page .supported-logos-multi-row .link-container .arrow-link, .page-template-product-database-page .supported-logos-multi-row .link-container .arrow-link { display: block; text-decoration: none; } /* White text, specifically checkbox label on dark background */ .page-template-product-child-page .pricing-block #gform_wrapper_62 .gfield_checkbox label { color: #fff; } /*Bulleted List with X bullets (Blog) */ ul.fancy-list-x { max-width: 100%; list-style: none; margin-left: 0; margin-bottom: 0; } ul.fancy-list-x li { padding-left: 1.5625rem !important; margin-bottom: 22px; position: relative !important; font-size: 16px; line-height: 25px; letter-spacing: 0.5px; font-family: 'Proxima Nova', 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; max-width: 100%; } ul.fancy-list-x li .svg-inline--fa { content: '' !important; display: inline-block !important; } ul.fancy-list-x li::before, ul.fancy-list-x li .svg-inline--fa { position: absolute; top: 4px; right: auto; bottom: auto; left: 0; content: '\f057' !important; width: auto !important; height: 1rem !important; display: none; font-size: 0.7rem !important; font-family: 'Font Awesome 5 Solid' !important; color: #ff0000 !important; } ul.fancy-list-x li .svg-inline--fa path { color: #ff0000 !important; } /* NEW SIDE MENU MISSING CODE FROM BUILD override*/ .new-side-menu { position: fixed; right: 0; top: 12.5rem; background: rgba(245, 245, 245, 0.9); box-shadow: 0px 4px 20px rgba(0, 0, 0, 0.1); backdrop-filter: blur(30px); border-radius: 0.5rem 0 0 0.5rem; padding: 1.875rem 1.25rem; width: 14.6875rem; display: none; } @media screen and (min-width: 101.25em) { .new-side-menu.show { display: block; } } .new-side-menu ul { list-style: none; margin-left: 0; margin-bottom: 0; text-align: right; } .new-side-menu ul li { margin: 0; } .new-side-menu ul li ~ li { margin-top: 0.8125rem; } .new-side-menu ul li a { font-family: 'Proxima Nova', 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-style: normal; font-weight: 400; font-size: 14px; line-height: 24px; letter-spacing: 0.5px; text-decoration: none; color: #001d2e; position: relative; display: flex; align-items: center; justify-content: flex-end; } .notification-bar { position: static; background: #6a6ef4; } .notification-bar a, .notification-bar a:hover, .notification-bar p { color: #ffffff; } .new-side-menu ul li a:hover { color: #00b471; } .new-side-menu ul li a:after { content: ''; display: block; width: 0.4375rem; height: 0.4375rem; background: transparent; border: 0.0625rem solid #767676; border-radius: 50%; margin-left: 0.625rem; } .new-side-menu ul li a.active { color: #00b471; } .new-side-menu ul li a.active:after { background: #00b471; border-color: #00b471; } /*Tech Support Right-side Boxes*/ .flexible-tech-support { padding: 60px 0; } @media print, screen and (min-width: 64em) { .flexible-tech-support { padding: 100px 0; } } @media print, screen and (min-width: 64em) { .flexible-tech-support h2 { margin-bottom: 40px; } } .flexible-tech-support h4 { color: #0067a6; } .flexible-tech-support a { text-decoration: none; font-weight: initial; } .flexible-tech-support .card { background: #fff; margin-bottom: 22px; padding: 40px 30px; border: solid 1px #6a6ef4; display: flex; flex-direction: column; align-items: flex-start; justify-content: center; box-shadow: 0px 10px 24px rgba(106, 110, 244, 0.15); } .flexible-tech-support .card.dark { background: linear-gradient(84.29deg, #001d2e 1.61%, #00314e 74.62%); } .flexible-tech-support .card.dark h4, .flexible-tech-support .card.dark p, .flexible-tech-support .card.dark a { color: #fff !important; } @media screen and (max-width: 39.99875em) { .flexible-tech-support .card h4 { font-size: 25px; } } @media print, screen and (min-width: 40em) { .flexible-tech-support .card { height: 100%; margin-left: 12px; margin-right: 12px; } } .flexible-tech-support .card p { font-size: 16px; line-height: 25px; letter-spacing: 0.5px; color: #767676; } .flexible-tech-support .card .arrow-link { font-weight: bold; } .js-error-log p { background: #fff9f9; border: 1px solid #c02b0a; font-size: 14.992px; margin-top: 8px; color: #c02b0a !important; padding: 12.992px 24px; clear: both; font-family: inherit; font-size: 15px; letter-spacing: normal; line-height: inherit; padding-top: 13px; width: 100%; font-weight: bold !important; } .resource-tab__item { position: relative; padding-top: rem-calc(40) !important; } .item-absolute { font-weight: bold; position: absolute; padding: 10px 20px; top: 0; right: 0; background: #001d2e; color: #a6a9ff; pointer-events: none; margin: 0; } /*Add padding to display "data-type" labels on portal resource boxes*/ @media print, screen and (min-width: 64em) { .portal-resource-list .resource-tab__item { padding: 40px 40px 20px 40px; /*color: blue;*/ } } ul.fancy-list li::before, ul.fancy-list li .svg-inline--fa { position: absolute; top: 4px; right: auto; bottom: auto; left: 0; } ul.fancy-list li::before, ul.fancy-list li svg { position: absolute; top: 4px; right: auto; bottom: auto; left: 0; } .portal-resource-list .resource-tab__item { padding: 40px 40px; padding-top: 50px; } #gform_wrapper_71 { max-width: 636px; margin: auto; padding: 30px 20px; box-shadow: 0px 5px 18px 0px rgba(106, 110, 244, 0.3); } @media print, screen and (min-width: 40em) { #gform_wrapper_71 { padding: 50px 74px; } } #gform_wrapper_71 h2 { max-width: 700px; margin: auto; text-align: center; color: #0067a6; } #gform_wrapper_71 h5 { color: #6a6ef4; } #gform_wrapper_71 .ginput_complex { display: block; } #gform_wrapper_71 .ginput_complex span { display: block; padding: 0px; margin: 0px; } #gform_wrapper_71 .ginput_complex span:first-child { margin-bottom: 16px; } #gform_wrapper_71 .form-position { display: flex; flex-wrap: wrap; justify-content: center; align-items: center; background: #f1f5fa; padding: 13px; margin: 22px 0; } @media print, screen and (min-width: 64em) { #gform_wrapper_71 .form-position { margin: 42px 0; margin-bottom: 62px; } } #gform_wrapper_71 .form-position p { margin-bottom: 0px; font-size: 14px; line-height: 18px; letter-spacing: 0.8px; color: #0067a6; font-weight: bold; max-width: 90px; } #gform_wrapper_71 .form-position p.active { color: #6a6ef4; } #gform_wrapper_71 .form-position span { background: #0067a6; color: #fff; width: 30px; height: 30px; display: flex; align-items: center; justify-content: center; border-radius: 50%; margin: 0 22px; } #gform_wrapper_71 .gfield_label { font-size: 16px; line-height: 24px; color: #0067a6; font-weight: bold; } #gform_wrapper_71 input[type='text'], #gform_wrapper_71 input[type='email'], #gform_wrapper_71 textarea { background: #ffffff; border: 1px solid #8baed4; } #gform_wrapper_71 input[type='text']::placeholder, #gform_wrapper_71 input[type='email']::placeholder, #gform_wrapper_71 textarea::placeholder { color: #767676; } #gform_wrapper_71 #input_13_8 { border: none; padding: 0px !important; } #gform_wrapper_71 select { padding-right: 33px !important; color: #767676; } #gform_wrapper_71 select::placeholder { color: #767676; } #gform_wrapper_71 #field_6_8 label { font-size: 16px; line-height: 19px; letter-spacing: 3px; text-transform: uppercase; color: #6a6ef4; } #gform_wrapper_71 #field_6_8 .gfield_description { font-size: 16px; line-height: 24px; color: #0067a6; font-weight: bold; } #gform_wrapper_71 #field_6_8 #file-upload-button { border: 1px solid #001d2e; box-sizing: border-box; box-shadow: 0px 16px 24px rgba(106, 110, 244, 0.184583); border-radius: 2px; padding: 24px; background: #fff; } #gform_wrapper_71 fieldset .gfield_label { font-size: 16px; line-height: 24px; color: #0067a6; font-weight: bold; } #gform_wrapper_71 #gform_submit_button_6, #gform_wrapper_71 .gform_next_button { width: 100%; } #gform_wrapper_71 .gform_previous_button, #gform_wrapper_71 .gform_fileupload_rules { display: none; } #gform_wrapper_71 #gfield_instruction_13_29 { display: none; } #gform_wrapper_71 #input_13_28 { display: flex; margin-bottom: 0px; } #gform_wrapper_71 #field_13_29 .gfield_description, #gform_wrapper_71 #field_13_30 .gfield_description, #gform_wrapper_71 #field_13_26 .gfield_description { display: block; font-size: 14px; color: #767676; background: #fff; padding: 4px 10px; margin-top: 10px; } #gform_wrapper_71 #field_13_29 .gform_page_footer input + input, #gform_wrapper_71 #field_13_30 .gform_page_footer input + input, #gform_wrapper_71 #field_13_26 .gform_page_footer input + input { margin-left: 0px; } /* Blog Author */ .content-area section.nv-author { padding-bottom: 80px !important; } .nv-author { background-color: #f1f2f2; margin-top: 30px; padding-top: 30px; padding-left: 30px; padding-right: 30px; } .nv-author__image { float: left; margin-right: 20px; } .single-post h4.nv-author__name { margin-bottom: 5px; color: #6a6ef4; } .nv-author__description { clear: both; padding-top: 10px; font-size: 0.9rem; } /* Segmentations */ .page-id-13757 .grid-container #gform_wrapper_81 { display: flex; align-items: center; justify-content: center; } .page-id-13757 #gform_wrapper_81 .gchoice label { color: #767676; line-height: 24px; letter-spacing: 1.125px; } /* Nurture Footer Form */ /* Academia */ .subscribe-cta .grid-container .gform_wrapper #field_55_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_55_1 .ginput_container { width: 100%; } /* ADMS */ .subscribe-cta .grid-container .gform_wrapper #field_28_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_28_1 .ginput_container { width: 100%; } /* Chemists/Analysts */ .subscribe-cta .grid-container .gform_wrapper #field_65_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_65_1 .ginput_container { width: 100%; } /* Chrom */ .subscribe-cta .grid-container .gform_wrapper #field_42_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_42_1 .ginput_container { width: 100%; } /* Elucidation & Verification */ .subscribe-cta .grid-container .gform_wrapper #field_63_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_63_1 .ginput_container { width: 100%; } /* Impurities */ .subscribe-cta .grid-container .gform_wrapper #field_46_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_46_1 .ginput_container { width: 100%; } /* Luminata PharmDev & Regulatory */ .subscribe-cta .grid-container .gform_wrapper #field_40_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_40_1 .ginput_container { width: 100%; } /* MS */ .subscribe-cta .grid-container .gform_wrapper #field_31_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_31_1 .ginput_container { width: 100%; } /* NMR */ .subscribe-cta .grid-container .gform_wrapper #field_44_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_44_1 .ginput_container { width: 100%; } /* Parallel Chem & HTE */ .subscribe-cta .grid-container .gform_wrapper #field_43_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_43_1 .ginput_container { width: 100%; } /* Percepta/Property Prediction */ .subscribe-cta .grid-container .gform_wrapper #field_78_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_78_1 .ginput_container { width: 100%; } /* Structure Drawing */ .subscribe-cta .grid-container .gform_wrapper #field_45_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_45_1 .ginput_container { width: 100%; } .gform_wrapper #field_74_20 .gfield_radio { display: flex; } .gform_wrapper #field_74_20 .gchoice { margin-right: 30px; } .color-js { color: #00adee; } .deployment { position: absolute; padding: 10px 30px; top: 0; left: 0; font-size: 1.5em; font-style: italic; } .page-template-product-child-page .text-editor .main-color-green .js-list ul ::marker{ color: #00adee; !important } /*Portal Difficulty*/ .portal-resource-list .resource-tab__item .item-difficulty.qsg { background: #EDFCF5; color: #2C664A; } .portal-resource-list .resource-tab__item .item-difficulty.training { background: #FCF7ED; color: #735132; } .portal-resource-list .resource-tab__item .item-difficulty { top: 20px; } /*Spectrus JS Page*/ @media print, screen and (min-width: 40em) .site-hero .cell, .page-id-1389 .site-hero .cell { max-width: 680px; text-align: left; margin-top: 32px; } .page-id-1389 .site-hero .cell { max-width: 680px; text-align: left; margin-top: 32px; } .page-id-1389 .site-hero__title { color: #00FFA0; font-size: 24px; line-height: 29px; letter-spacing: 3px; text-align: left; } .page-id-1389 .supported-logos { padding-top: 40px; padding-bottom: 80px; } .page-id-1389 .supported-logos .logos { list-style: none; max-width: 1000px; margin-left: auto; margin-right: auto; display: flex; align-items: center; justify-content: center; flex-wrap: wrap; } .page-id-1389 .supported-logos .logos li { width: 100px; margin: 15px; } .page-id-1389 .supported-logos .link-container { margin-top: 20px; } .page-id-1389 .supported-logos .link-container .arrow-link { display: block; text-decoration: none; }.page-id-1389 .fancy-list li::before, .page-id-1389 .fancy-list li .svg-inline--fa, .page-id-1389 .fancy-list li .svg-inline--fa path{ color: #00B471 !important; } .page-id-1389 .icon-item-row .icon-item img{ height: 60px; width: auto; margin-bottom: 15px; } .page-id-1389 .icon-item-row .icon-item { margin: 15px; display: flex; flex-direction: column; align-items: center; } /*Products Mega Menu*/ .flyout.submenu-1, .site-header.is-opaque .site-bar .site-navigation .sub-menu.submenu-1, .site-header .site-bar .site-navigation .sub-menu.submenu-1 { background-color: #fff; background-image: none; } /*Spectrus Processor*/ .pricing-block .button.green, .comments-area .comment-form .form-submit input[type="submit"], .button--inline-form, .hero--advanced .hero__transform-container .hero__button { background: linear-gradient(to right, #00B471, #00FFA0); border-radius: 2px; font-weight: 800; box-shadow: 0px 16px 24px rgba(106, 110, 244, 0.243098); border: none; line-height: 24px; letter-spacing: 0.8px; text-decoration: none; color: #0a0a0a; } .pricing-block .button.white { background: transparent !important; box-shadow: none; border: solid 1px #fff; color: #fff !important; } .color-lt-green{ color:#00ffa0; } .disclaimer { font-size: .85em; } /*Form Labels */ [type='checkbox'] + label, [type='radio'] + label { display: inline; } /*ChemSketch Freeware*/ .page-id-3441 .demo-cta { position: relative; } .page-id-3441 .demo-cta .background { position: absolute; top: 0; left: 0; width: 100%; height: 100%; background-size: cover; background-position: center; z-index: 0; } .page-id-3441 .demo-cta #gform_wrapper_8 { background: #0a0a0a; position: relative; z-index: 1; margin-top: -50px; margin-bottom: -50px; padding: 40px 20px; } @media print, screen and (min-width: 40em) .page-id-3441 .demo-cta #gform_wrapper_8 { padding: 70px 60px; padding-bottom: 30px; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_html { text-align: center; color: #fff; } .page-id-3441 .demo-cta.form-color-purple h3 { color: #A6A9FF; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_html h3{ margin-bottom: 12px; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_checkbox { margin-bottom: 0px !important; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_checkbox label { color: #fff; display: inline; } .page-id-3441 .demo-cta #gform_wrapper_8 .button { margin-top: 22px; display: block; width: 100%; } .page-id-3441 .demo-cta #gform_confirmation_wrapper_8 { background: #0a0a0a; position: relative; z-index: 1; margin-top: -50px; margin-bottom: -50px; padding: 40px 20px; } .page-id-3441 .demo-cta #gform_confirmation_wrapper_8 .gform_confirmation_message { background: none; border: none; } /*Flexible Layouts */ /* Icon Item Row */ .page-template-default .icon-item-row .icon-item { margin: 15px; display: flex; flex-direction: column; align-items: center; } /*Sidebar Content Bullets */ .page-template-default .flexible-sidebar-content .flexible-sidebar ul.fancy-list li .svg-inline--fa path { color: #fff !important; } .page-template-default blockquote { font-size: inherit; padding-left: 30px; padding-right: 30px; } /* Steps Block */ .page-template-default .steps-block .content { padding: 60px 20px; color: #fff; background-size: cover; background-position: center; } @media print, screen and (min-width: 40em) .page-template-default .steps-block .content .content-container { max-width: 22rem; margin-left: auto; margin-right: 2rem; } .page-template-default .steps-block .content .content-container { max-width: 22rem; margin-left: auto; margin-right: 2rem; } @media print, screen and (min-width: 40em) .page-template-default .steps-block .steps .content-container { max-width: 37rem; margin-left: 2rem; margin-right: auto; } .page-template-default .steps-block .steps .content-container { max-width: 37rem; margin-left: 2rem; margin-right: auto; } .page-template-default .steps-block .content-container { height: 100%; display: flex; flex-direction: column; justify-content: center; } .page-template-default .steps-block .steps { padding: 60px 20px; } .page-template-default .steps-block .steps ul { list-style: none; } .page-template-default .steps-block .steps li { position: relative; border-left: solid 1px #6A6EF4; padding-left: 40px; padding-bottom: 40px; padding-top: 10px; color: #fff; margin-bottom: 0px; } .page-template-default .steps-block .steps li .count { position: absolute; width: 40px; height: 40px; border-radius: 50%; background: #6A6EF4; color: #fff; display: flex; align-items: center; justify-content: center; font-weight: bold; left: -20px; top: 0px; } .page-template-default .steps-block .steps li:last-child { padding-bottom: 0px; } .page-template-default .icon-item-row .icon-item img { height: 70px; width: auto; margin-bottom: 15px; } /*Spectrus Processor JS */ #gform_wrapper_35 .gform_footer input[type=submit] { background: linear-gradient(to right, #FFFFFF, #8BAED4); color:#011d2e; } .page-id-13941 .simple-cta .link-container { justify-content: flex-start; } #gform_confirmation_wrapper_35 .gform_confirmation_message { border: none; background: #777bf5; color:#FFFFFF; } @media print, screen and (min-width: 64em) .single-portal-resource .main-content { padding-right: 30px; } .single-portal-resource .main-content { padding-right: 30px; } /* Blog Edits for Mobile */ @media only screen and (max-width: 600px) { /* Display email field as 100% width */ .post-template-default .gform_wrapper.gravity-theme .gfield.gfield--width-half { grid-column: span 12; } /* Hide form on top of Related Posts */ .blog-subscribe-cta { display:none; } /* Display images full width */ .post-template-default img { width:100%; } } /* Blog Edits for all sign-up forms */ .post-template-default .nv-blog-post .grid-container { padding: 0px; } .blog-subscribe-cta{ margin-bottom: 30px; } /*Blog Sign-up Form - ADMS */ .post-template-default .nv-blog-post #gform_28 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_28 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_28{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_28_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_28 #field_28_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_28 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_28 h4{ color: #FFFFFF; } #gform_wrapper_28 .gform_footer { margin-top: 0px; } #gform_wrapper_28 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar ADMS */ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_28 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_28 #field_28_1 #field_28_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_28 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_28_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - ChemSketch */ .post-template-default .nv-blog-post #gform_45 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_45 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_45{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_45_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_45 #field_45_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_45 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_45 h4{ color: #FFFFFF; } #gform_wrapper_45 .gform_footer { margin-top: 0px; } #gform_wrapper_45 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar ChemSketch */ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_45 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_45 #field_45_1 #field_45_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_45 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_45_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Chrom*/ .post-template-default .nv-blog-post #gform_42 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_42 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_42{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_42_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_42 #field_42_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_42 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_42 h4{ color: #FFFFFF; } #gform_wrapper_42 .gform_footer { margin-top: 0px; } #gform_wrapper_42 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Chrom*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_42 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_42 #field_42_1 #field_42_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_42 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_42_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Katalyst*/ .post-template-default .nv-blog-post #gform_43 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_43 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_43{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_43_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_43 #field_43_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_43 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_43 h4{ color: #FFFFFF; } #gform_wrapper_43 .gform_footer { margin-top: 0px; } #gform_wrapper_43 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Katalyst*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_43 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_43 #field_43_1 #field_43_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_43 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_43_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Luminata*/ .post-template-default .nv-blog-post #gform_40 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_40 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_40{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_40_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_40 #field_40_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_40 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_40 h4{ color: #FFFFFF; } #gform_wrapper_40 .gform_footer { margin-top: 0px; } #gform_wrapper_40 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Luminata*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_40 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_40 #field_40_1 #field_40_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_40 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_40_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - MS */ .post-template-default .nv-blog-post #gform_31 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_31 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_31 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_31_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_31 #field_31_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_31 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_31 h4{ color: #FFFFFF; } #gform_wrapper_31 .gform_footer { margin-top: 0px; } #gform_wrapper_31 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar MS */ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_31 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_31 #field_31_1 #field_31_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_31 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_31_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - NMR*/ .post-template-default .nv-blog-post #gform_44 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_44 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_44 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_44_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_44 #field_44_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_44 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_44 h4{ color: #FFFFFF; } #gform_wrapper_44 .gform_footer { margin-top: 0px; } #gform_wrapper_44 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar NMR*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_44 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_44 #field_44_1 #field_44_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_44 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_44_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Percepta*/ .post-template-default .nv-blog-post #gform_78 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_78 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_78 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_78_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_78 #field_78_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_78 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_78 h4{ color: #FFFFFF; } #gform_wrapper_78 .gform_footer { margin-top: 0px; } #gform_wrapper_78 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Percepta*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_78 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_78 #field_78_1 #field_78_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_78 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_78_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Verification*/ .post-template-default .nv-blog-post #gform_63 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_63 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_63 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_63_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_63 #field_63_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_63 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_63 h4{ color: #FFFFFF; } #gform_wrapper_63 .gform_footer { margin-top: 0px; } #gform_wrapper_63 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Verification*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_63 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_63 #field_63_1 #field_63_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_63 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_63_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Newsletter*/ .post-template-default .nv-blog-post #gform_2 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_2 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_2 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_2_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_2 #field_2_2{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_2 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_2 h4{ color: #FFFFFF; } #gform_wrapper_2 .gform_footer { margin-top: 0px; } #gform_wrapper_2 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Newsletter*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_2 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_2 #field_2_2 #field_2_1 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_2 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_2_2 .ginput_container { width: 100%; } /*Remove bullet from AutoChrom table */ #autochrom_modal.reveal .slick-slide table td:not(.heading):before { content: ''; position: absolute; top: 0px; left: 0px; } /* Add background color to header row */ #autochrom_modal.reveal .slick-slide table th.heading { color: #FFFFFF !important; font-size: 20px !important; text-align: center !important; background-color: #00B471 !important } /* Add background color to tabs to distinguish them @media screen and (min-width: 768px) .simple-tab .tabs.converted-tab li a.selected { background-color: #00B471; }*/ /* START Marek Logo Updates */ body .site-branding__logo img, body .site-branding__logo svg, body .site-branding__alt-logo img, body .site-branding__alt-logo svg { width: 225px !important; height: auto !important; max-width: 100%; } body .site-header .site-bar .site-navigation .layer-2 ul.main-nav .top-link { padding-right: 8px; } body .site-header .site-bar .site-navigation .layer-2 ul.main-nav .menu-item.has-children .top-link svg { font-size: 11px; margin-left: 0; } body .site-header.transparent.is-opaque .site-branding__alt-logo { display: flex; align-items: center; justify-content: flex-start; } body .site-header.site-header .site-bar .site-navigation .layer-2 ul.main-nav .top-link { font-size: 13px; font-weight: 600; } body .layer-1 a:not(.login):not(.register) { font-weight: 700; } body .site-header a { -webkit-font-smoothing: antialiased; } /* END Marek Logo Updates */ .widecolumn { margin: 0 auto 600px; text-align: center; padding: 100px 15px 0; max-height: 1200px; } .reveal{ transition: 0s; } /* Scroll up for bookmarks on Symposium page */ #day1 { scroll-margin-top: 120px; } #day2 { scroll-margin-top: 120px; } #register { scroll-margin-top: 120px; } #posters { scroll-margin-top: 120px; } #symposium { scroll-margin-top: 120px; } #refer { scroll-margin-top: 200px; } #percepta { scroll-margin-top:500px; } /* flexible Event Agenda */ .page-template-default .symposium-agenda { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .page-template-default .symposium-agenda .agenda-block { padding: 0px 40px; width: 100%; max-width: 996px; margin: auto; margin-top: 30px; background: #fff; border-top: solid 4px #6A6EF4; border-radius: 4px; box-shadow: 0px 5px 18px 0px rgba(106, 110, 244, 0.3); overflow: hidden; position: relative; height: auto !important; } .page-template-default .symposium-agenda .agenda-block__item { padding: 25px 0px; border-bottom: 1px solid rgba(118, 118, 118, 0.1); } .page-template-default .symposium-agenda .agenda-block__item .time-frame { color: #6A6EF4; } .page-template-default .symposium-agenda .agenda-block__item .item-title { color: #0067A6; font-size: 16px; line-height: 24px; } .page-template-default .speaker { display: flex; align-items: center; margin-bottom: 16px; padding-right: 16px; line-height: 1.2; } .page-template-default .speaker .headshot { display: block; width: 65px; height: 65px; border-radius: 50%; overflow: hidden; background: #f1f1f1; background-size: cover; background-position: center; margin-right: 14px; flex: 0 0 67px; } .page-template-default .webinar-single-hosts { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .page-template-default .webinar-single-hosts h5 { margin-bottom: 45px; } .page-template-default .webinar-single-hosts .speaker { align-items: flex-start; } .page-template-default .speaker div { width: 100%; } .page-template-default .event-meta { flex-wrap: wrap; margin-top: 16px; margin-bottom: 20px; display:block; } @media print, screen and (min-width: 64em) .page-template-default .symposium-agenda { padding: 70px 0; padding-bottom: 100px; } .webinar-single-hosts { padding: 70px 0; padding-bottom: 100px; } #gform_wrapper_74 .gfield_label { color: #FFFFFF; } /* Blog Heading 5 */ .single-post .single-entry__content h5 { color: #0067A6; font-style: italic; } /* Discount Code Coupon Box */ .woocommerce #content table.cart td.actions .input-text, .woocommerce table.cart td.actions .input-text, .woocommerce-page #content table.cart td.actions .input-text, .woocommerce-page table.cart td.actions .input-text { width:150px; } .disclaimer #content p { padding: 20px 0; } /* Registration form on Webinar Resource page */ #gform_wrapper_96{ background: #001D2E; position: relative; z-index: 1; padding: 40px 20px; @include breakpoint(medium){ padding: 50px; padding-bottom: 30px; } .gfield_html{ text-align: center; color: #fff; h3{ margin-bottom: 12px; color: #A6A9FF; } } .gchoice label { color: #fff; margin-right: 0px; } .gfield_checkbox{ margin-bottom: 0px; } .button{ margin-top: 0px; display: block; width: 100%; } input, select{ color: #767676; font-weight: bold; } input[type="submit"]{ color: #fff; } } /* Event Agenda on Resource Pages */ .single-resources .symposium-agenda { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .single-resources .symposium-agenda .agenda-block { padding: 0px 40px; width: 100%; max-width: 996px; margin: auto; margin-top: 30px; background: #fff; border-top: solid 4px #6A6EF4; border-radius: 4px; box-shadow: 0px 5px 18px 0px rgba(106, 110, 244, 0.3); overflow: hidden; position: relative; } .single-resources .symposium-agenda .agenda-block__item { padding: 25px 0px; border-bottom: 1px solid rgba(118, 118, 118, 0.1); } .single-resources .symposium-agenda .agenda-block__item .item-title { color: #0067A6; font-size: 16px; line-height: 24px; } .single-resources .speaker { display: flex; align-items: center; margin-bottom: 16px; padding-right: 16px; line-height: 1.2; } .single-resources .speaker .headshot { display: block; width: 65px; height: 65px; border-radius: 50%; overflow: hidden; background: #f1f1f1; background-size: cover; background-position: center; margin-right: 14px; flex: 0 0 67px; } .single-resources .webinar-single-hosts { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .single-events .webinar-single-hosts h5 { margin-bottom: 45px; } .single-events .webinar-single-hosts .speaker { align-items: flex-start; } .single-events .speaker { display: flex; align-items: center; margin-bottom: 16px; padding-right: 16px; line-height: 1.2; } .single-resources .related-events { padding-top: 80px; } @media print, screen and (min-width: 64em) { .single-resources .symposium-agenda { padding: 70px 0; padding-bottom: 100px; } } @media print, screen and (min-width: 64em) { .single-resources .webinar-single-hosts { padding: 70px 0; padding-bottom: 100px; } } @media print, screen and (min-width: 64em) { .single-resources .related-events { padding-top: 110px; 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Safety Endpoints</p> <p><a class="button primary" href="#product_demo">Request a Consultation or Demo</a></p> </div> </div> </div> </section> <!-- Content Area --> <div id="content-area" class="content-area"> <section class="overview"> <div class="grid-container"> <div class="grid-x"> <div class="cell text-center small-12"> <h5 class="section-heading">Tox Suite Overview</h5> </div> <div class="cell medium-4"> <h3>Predictors &amp; Calculators for Toxicity Endpoints</h3> </div> <div class="cell medium-8"> <p>ACD/Tox Suite provides high-quality, structure-based calculation of toxicity endpoints. Early in silico toxicity screening can help reduce attrition rates of molecular entities that are unlikely to succeed to nomination as a drug candidate. The toxicity profile can also help direct new compound synthesis and focus animal testing requirements.</p> <p>Tox Suite is a collection of prediction modules that offer insightful, structure-based calculations of toxicity.</p> <ul class="fancy-list"> <li>Predict from structure: <ul> <li>Acute toxicity*</li> <li>Aquatic toxicity*</li> <li>Endocrine system disruption</li> <li>Mutagenicity*</li> <li>Adverse effects on organs</li> <li>hERG inhibition*</li> <li>Irritation</li> <li>Physicochemical properties—log<em>P</em>,* log<em>D</em>,* pK<sub>a</sub>,* aqueous solubility,* etc.</li> </ul> </li> </ul> <p>*These modules may be trained with experimental data</p> <ul class="fancy-list"> <li>Assess the reliability of predicted values</li> <li>Search the internal library of experimental data for select models</li> <li>Train prediction models with experimental data to better reflect novel chemical space</li> <li>Include custom models and in-house prediction algorithms</li> </ul> </div> </div> </div> </section> <!-- Flexible Content - Before Main Content --> <section class="icon-item-row" id="benefits" data-menu="Benefits" data-magellan-target="benefits"> <div class="grid-container"> <div class="grid-x align-center"> <div class="cell text-center "> <h5 class="section-heading color-orange">Benefits</h5> <h2 class="color-primary margin-auto" style="max-width: 650px">Everything You Need in a Toxicity Predictor </h2> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Easy-to-Use-2.png?fit=40%2C62&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Easy to Use</span></h4> <ul class="fancy-list"> <li>Simply draw/import your structure for predictions—easy enough for medicinal, synthetic, and research chemists to use</li> <li>You don’t need to be a software engineer or programmer to train the models</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Quickly-Assess-the-Toxicity-of-Impurities-_-Degradants.png?fit=60%2C60&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Fast, Accurate, Reliable Results</span></h4> <ul class="fancy-list"> <li>Quickly calculate properties for single compounds or tens of thousands</li> <li>Predictions are based on carefully curated databases of experimental data</li> <li>Easily evaluate the reliability of results with a reliability index, a display of similar structures, and literature references for the original experimental data</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Convenient-Visualization-1.png?fit=54%2C60&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Convenient Visualization</span></h4> <ul class="fancy-list"> <li>Visualize substructure/atomic contributions to a property value with color-mapping on the structure (select modules)</li> <li>Quickly identify favorable and unfavorable compounds in a library with user-defined color-coding of results in spreadsheet view</li> </ul> </div> </div> </div> </div> </section><section class="icon-item-row" style="padding-top:0.1px" > <div class="grid-container"> <div class="grid-x align-center"> <div class="cell text-center "> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Deeper-Insights-1.png?fit=58%2C60&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Deeper Insights</span></h4> <ul class="fancy-list"> <li>Identify trends and prioritize compounds easily—create scatter plots, browse, filter, sort, and rank libraries of compounds</li> <li>Make confident decisions with the complete property profile of molecules in one place</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Customizable-with-In-House-Data.png?fit=70%2C67&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Customizable with In-House Data</span></h4> <ul class="fancy-list"> <li>Get the accuracy of in-house models from a commercial product. Use your own experimental data to expand the applicability domain of trainable modules</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Expandable-to-Third-Party-Models-1.png?fit=60%2C60&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Expandable to Third-Party Models</span></h4> <ul class="fancy-list"> <li>Create a single environment for predicted data by including third-party and in-house models</li> </ul> </div> </div> </div> </div> </section><section class="views-slider-container" > <div class="grid-container"> <div class="cell"> <div class="views-slider arrow-color-orange"> <div> <div class="view"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Tox_hERG.png?fit=1326%2C734&#038;quality=80&#038;ssl=1" alt="" /> </div> <p class="caption">Explore the influence of pK<sub>a</sub> and log<em>P</em> on hERG inhibition potential</p> </div> <div> <div class="view"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Tox_Mutagenicitiy.png?fit=1326%2C734&#038;quality=80&#038;ssl=1" alt="" /> </div> <p class="caption">Predict the probability of a positive Ames test—color mapped structure highlighting helps identify contributing structure elements.</p> </div> <div> <div class="view"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Acute-Tox.png?fit=1326%2C734&#038;quality=80&#038;ssl=1" alt="" /> </div> <p class="caption">Calculate lethal dose. Review experimental values for similar structures and add your own data to build reference library.</p> </div> <div> <div class="view"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Tox_Irritation.png?fit=1326%2C734&#038;quality=80&#038;ssl=1" alt="" /> </div> <p class="caption">Assess the probability of irritation potential (Draize test) for both eyes and skin</p> </div> </div> </div> </div> </section><section class="steps-block" style="background: #001D2E" id="how-it-works" data-menu="How it Works" data-magellan-target="how-it-works"> <div class="grid-container-fluid"> <div class="grid-x"> <div class="cell medium-5 content button-color-orange" style="background-image: url(https://www.acdlabs.com/wp-content/themes/acd-labs/lib/admin/images/flexible-defaults/How_it_works_img.png)"> <div class="content-container"> <h5 class="section-heading"><span style="color: #ff764c;">How it Works</span></h5> <h2><span style="color: #ffffff;">Predictions in Seconds with Tox Suite</span></h2> <p><a class="button primary" href="#product_demo">Request a Consultation or Demo</a></p> <p>&nbsp;</p> </div> </div> <div class="cell medium-7 steps step-color-orange"> <div class="content-container"> <ul> <li> <span class="count">1</span> Draw/import your structure </li> <li> <span class="count">2</span> Select the property of interest </li> <li> <span class="count">3</span> Review results and make decisions </li> <li> <span class="count">4</span> Conveniently copy/paste results or report to PDF </li> </ul> </div> </div> </div> </div> </section> <section class="reviews" id="customer-reviews" data-menu="Customer Reviews" data-magellan-target="customer-reviews"> <div class="grid-container"> <div class="cell"> <h5 class="section-heading color-orange">Customer Reviews</h5> </div> <div class="review-slider"> <div class="item"> <blockquote>“The best in silico toxicity software I have used. It was very easy to use, and a lot of information could be obtained.”</blockquote> <p class="meta"> Tim Tam<br /> Apotex Pharma </p> </div> <div class="item"> <blockquote>“Merck Germany has deployed Percepta Enterprise software at their Research facilities in Germany and North America. It provides in silico tools for the prediction of Physicochemical, ADME and Tox properties, helping support the medicinal chemists in their planning of syntheses and optimization of new chemical entities. Their main reasons for choosing ACD/Labs Percepta Enterprise were its ease of use and, in particular, its configurability and ability to use existing in-house built algorithms.”</blockquote> <p class="meta"> <br /> </p> </div> </div> </div> </section><section class="flexible-vertical-tabs main-color-orange" style="background:#F1F5FA;" id="product-features" data-menu="Product Features" data-magellan-target="product-features"> <div class="grid-container"> <div class="grid-x"> <div class="cell text-center "> <h5 class="section-heading ">Product Features</h5> <h2 class="color-primary">Toxicity Endpoint Calculator Features</h2> </div> <div class="cell tab-container"> <div class="grid-x"> <div class="cell large-4"> <ul class="vertical tabs" data-tabs id="flexible-tabs-cO3gfbwI"> <li class="tabs-title is-active selected"> <a href="#panel_cO3gfbwI_1" aria-selected="true"> General Features </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_2" > Property-Based Structure Modification and Lead Optimization </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_3" > Acute Toxicity </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_4" > Aquatic Toxicity </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_5" > Endocrine System Disruption </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_6" > Mutagenicity </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_7" > Health Effects </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_8" > hERG Inhibition </a> </li> <li class="tabs-title "> <a href="#panel_cO3gfbwI_9" > Irritation </a> </li> </ul> </div> <div class="cell large-8"> <div class="tabs-content vertical" data-tabs-content="flexible-tabs-cO3gfbwI"> <div class="tabs-panel is-active" id="panel_cO3gfbwI_1"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Calculate toxicity endpoints for organic molecules from structure (draw in-app, or copy/paste from third-party drawing packages); SMILES string; InChI code; imported MOL, SK2, SKC, or CDX files; or search by name in the built-in dictionary</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Structure highlighting to indicate sub-structure/atomic contributions (present in some modules)</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Calculate toxicity endpoints for groups or libraries of compounds and use built-in tools to sort, filter, plot, and rank results <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Set user-defined label colors</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Filter results numerically</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Sort results by ascending/descending values</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Retrieve results of previously calculated values in your activity history</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Report results to PDF or copy/paste to your application of choice</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Download QMRF and QMRF documents for the Mutagenicity (Ames Test) module</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Train algorithms with experimental data in select modules—acute toxicity, aquatic toxicity, mutagenicity, hERG inhibition, log<em>P</em>, log<em>D</em>, and pK<sub>a</sub></li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Add custom models/algorithms and in-house prediction algorithms by connecting to an existing web service using an XML protocol, or with a DLL (available in thin client deployments only)</li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_2"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Gain insights into structure-property relationships</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Understand and modify the pharmacokinetic profile of lead compounds <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Good/bad indicators for Lipinksi’s rule-of-5, lead-likeness, and toxicity endpoints</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Identify structural fragments responsible for hazardous activity—hERG inhibition and mutagenicity</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Modify sets of structures with the interactive optimization tool <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Generate libraries of analogs with substituent modifications based on an optimal property profile</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Sort, filter, and prioritize hundreds of structural analogs according to your desired property profile</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Create and use custom fragment libraries</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Target synthetically accessible fragments with the built-in retrosynthesis tool</li> </ul> </li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_3"> <h4 style="color: #0067a6;">LD<sub>50</sub></h4> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Calculate LD<sub>50</sub> (mg/kg) for mice under oral, intraperitoneal, intravenous, and subcutaneous administration; and for rats under oral and intraperitoneal administration</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Reliability of prediction and display of 5 most similar structures in the internal library with experimental LD<sub>50</sub> values</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Train the model with experimental data</li> </ul> <h4 style="color: #0067a6;">Acute Toxicity Categories</h4> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict the probabilities that LD<sub>50</sub> will demonstrate various levels of acute toxicity following oral administration (based on rodent data)</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Categorize compounds for “Oral Acute Toxicity Hazard” as defined by the OECD (Organization for Economic Cooperation and Development) <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Hover over the label for details</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Display of 5 most similar structures in the internal library with experimental values</li> </ul> </li> </ul> <h4 style="color: #0067a6;">Hazards</h4> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Identify fragments that may be responsible for high acute toxicity <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Color-map on the structure</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Tabbed results provide detailed information for each fragment</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Learn how different routes of administration impact toxicity—intravenous, oral, and intraperitoneal</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Distribution density plot illustrating : <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">The frequency of compounds with different LD<sub>50</sub> ranges in the training set</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Compounds that contain the highlighted fragment</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">T-Test results demonstrating whether the presence of a highlighted fragment leads to a statistically significant increase in toxicity</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Box and whisker plot of compounds that contain the hazardous fragment compared with the full training set <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Display of the 5 most similar structures in the internal library with the selected hazardous fragment with experimental values</li> </ul> </li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_4"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict LC<sub>50</sub> values (mg/L) for Fathead minnow (<em>Pimephales promelas</em>) and Water flea (<em>Daphnia magna</em>)</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict IGC<sub>50</sub> values (mg/L) for <em>Ciliate protozoa</em> (<em>Tetrahymena pyriformis</em>)</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Reliability of prediction and display of 5 most similar structures in the internal library with experimental values</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Train the model with experimental data</li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_5"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict the probabilities of estrogen receptor binding affinity exceeding two different thresholds <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Classify the compounds by their relative binding affinity for the estrogen receptor compared to estradiol-based on LogRBA</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Reliability of prediction and display of 5 most similar structures in the internal library with experimental LogRBA values and literature references</li> </ul> </li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_6"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict the probability of a positive Ames test <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Color-map of atoms/functional groups in the structure that contribute to mutagenicity potential</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Reliability of prediction and display of 5 most similar structures in the internal library with overall experimental Ames test result</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Browse the mutagenicity database for: <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Information about studies conducted with each compound</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Tested bacterial strains</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">The presence or absence of metabolic activation, and other experimental conditions</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Train the model with experimental data</li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_7"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate the probability of adverse effects (at the therapeutic dose) for blood, cardiovascular system, gastrointestinal system, kidney, liver, and lungs</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Color-map of structural fragments that contribute to adverse effects</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Display of 5 most similar structures in the internal library with route, species, and a listing of clinically observed toxic effects.</li> </ul> </li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_8"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict the probability of human ether-a-go-go related gene (hERG) channel inhibition at clinically relevant concentrations (K<sub>i</sub> &lt; 10 μM)) using two different models—one based on structural descriptors, and one based on physicochemical properties <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Simulate how different experimental assays (e.g., conventional or automated patch-clamp, ligand replacement, etc.) impact the measured value of hERG inhibition potential</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Explore the influence of physicochemical and molecular properties on hERG inhibition potential</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Explore how physicochemical properties (acid/base pK<sub>a</sub>, log<em>P</em>) and molecular weight impact hERG inhibition <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Color &#8220;heat map&#8221; displays interdependence of hERG inhibition, pK<sub>a</sub>, and log<em>P</em></li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Reliability of prediction and display of 5 most similar structures in the internal library with experimental results (inhibitor, non-inhibitor) and literature references</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Train the model with experimental data</li> </ul> </div> <div class="tabs-panel " id="panel_cO3gfbwI_9"> <h4 style="color: #0067a6;">Eye Irritation</h4> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Calculate the probability of eye irritation in a standard Draize (rabbit) at 100mg and 500mg <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Statement of applicable rules and description of functional groups that contribute to eye irritation</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Highlighted contributing structural fragments</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Display of up to 5 most similar structures in the internal library with experimental values and literature references</li> </ul> </li> </ul> <h4 style="color: #0067a6;">Skin Irritation</h4> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Calculate the probability of skin irritation in a standard Draize (rabbit) at 100mg and 500mg <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Statement of applicable rules and description of functional groups that contribute to skin irritation</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Highlighted contributing structural fragments</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Estimate of prediction accuracy <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Display of up to 5 most similar structures in the internal library with experimental values and literature references</li> </ul> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </section><section class="icon-item-row" id="deployment-options" data-menu="Deployment Options" data-magellan-target="deployment-options"> <div class="grid-container"> <div class="grid-x align-center"> <div class="cell text-center "> <h5 class="section-heading color-orange">Deployment/Integration Options</h5> <h2 class="color-primary margin-auto" style="max-width: 650px">Choose the Deployment Option That Works for You</h2> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Thick-Client-1.png?fit=63%2C55&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Desktop/Thick Client</span></h4> <p style="text-align: center;">Install ACD/Tox Suite on individual computers to access the thick client which provides a full graphical user interface and access to algorithm training tools for trainable modules.</p> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Batch-1.png?fit=65%2C63&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Batch</span></h4> <p style="text-align: center;">Calculate toxicological property predictions for tens of thousands of compounds with minimal user intervention. Batch deployment is compatible with Microsoft Windows and Linux operating systems. Plug-in to corporate intranets or workflow tools such as Pipeline Pilot.</p> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Thin-Client-1.png?fit=61%2C62&#038;quality=80&#038;ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Percepta Portal/Thin Client</span></h4> <p style="text-align: center;">Use a browser-based application to predict toxicological endpoints. KNIME integration components are available. Host on your corporate intranet or the cloud. Available for Linux and Windows OS.</p> </div> </div> </div> </div> </section><section class="simple-cta main-color-orange" > <div class="grid-container"> <div class="grid-x"> <div class="content cell medium-8 large-9"> <h3><span style="color: #0067a6;">PhysChem Suite</span></h3> <p>Many toxicity endpoints are related to the physicochemical properties of a molecule. That is why we include PhysChem Suite with your purchase of Tox Suite.</p> </div> <div class="link-container cell medium-4 large-3"> <a class="button" href="/www.acdlabs.com/products/percepta-platform/physchem-suite/" target="_self">Learn More about PhysChem Suite</a> </div> </div> </div> </section><section class="text-editor" style="background:#001d2e; " id="more-reasons-to-use" data-menu="More Reasons to Use" data-magellan-target="more-reasons-to-use"> <div class="grid-container"> <div class="grid-x main-color-orange button-color-orange"> <div class="cell medium-6 column"> <h5 class="section-heading"><span style="color: #ff764c;">More Reasons to Use Tox Suite</span></h5> <h2><span style="color: #ffffff;">Trainable Calculators of Drug Toxicity &amp; Safety Endpoints</span></h2> <p><a class="button primary" href="#product_demo">Request a Consultation or Demo</a></p> </div> <div class="cell medium-6 column"> <p><span style="color: #ffffff;">Use curated experimental data to expand the training database and applicability domain of trainable models. The algorithms can be trained even if you aren&#8217;t a computational chemist or software engineer.</span></p> </div> </div> </div> </section><section class="text-editor" style="background:; " id="whats-new" data-menu="What's New" data-magellan-target="whats-new"> <div class="grid-container"> <div class="grid-x main-color-orange button-color-orange"> <div class="cell text-center "> <h5 class="section-heading color-orange">What's New!</h5> <h2 class="color-primary">What's New in Tox Suite v2024</h2> </div> <div class="cell medium-6 column"> <ul class="fancy-list"> <li>Expanded training library and Improved accuracy of the GALAS model for predicting genotoxicity (Ames Test)</li> <li>Expanded training libraries and improved accuracy of the aquatic toxicity modules (Daphnia and Tetrahymena predictors)</li> </ul> </div> <div class="cell medium-6 column"> <ul class="fancy-list"> <li>New and updated QSAR Prediction Reporting Format (QPRF) reports targeted for regulatory submissions in accordance with QSAR Assessment Framework</li> <li>Significant improvements and expanded chemical space coverage for pK<sub>a</sub>, log<em>P</em>, and log<em>D</em> predictions</li> </ul> </div> <div class="cell medium-12 column"> <p style="text-align: center;"><a class="button primary" href="/technical-support/current-software-versions/tox-suite/">Read the Full List of What&#8217;s New</a></p> </div> </div> </div> </section><section class="sorted-posts" id="learn-more" data-menu="Learn More" data-magellan-target="learn-more"> <div class="grid-container"> <div class="grid-x"> <div class="cell" style="padding-left: 15px;"> <h5 class="section-heading color-orange">Learn More about Tox Suite</h5> </div> </div> <div class="grid-x related_posts"> <div class="cell sorted-post-filters color-orange show-for-medium"> <button class="sorted-posts-filter is-active" data-filter="all"> All Resources</button> <button class="sorted-posts-filter" data-filter="blog"><i class="fas fa-comment-alt"></i>Blog</button> <button class="sorted-posts-filter" data-filter="articles"><i class="fas fa-file-signature"></i>Articles</button> <button class="sorted-posts-filter" data-filter="presentations"><i class="fas fa-presentation"></i>Presentations</button> </div> <div class="cell medium-6 large-4 sorted-posts-item blog color-orange"> <div class="card"> <span class="badge"><i class="fas fa-comment-alt"></i>Blog</span> <a href="https://www.acdlabs.com/blog/whats-hot-in-physchem/" class="content"> <a target="_blank" href="https://www.acdlabs.com/blog/whats-hot-in-physchem/" class="content"> <h4>Top 3 Trends in the World of Physicochemical Properties</h4> <p><p>Andrius Sazonovas, ACD/Labs Head of Development of Percepta, shares the key takeaways from the annual PhysChem Forum meeting that brings together scientists from industry and academia to discuss physical chemistry, ADME and toxicity.</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/blog/whats-hot-in-physchem/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item articles color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-signature"></i>Articles</span> <a target="_blank" href="https://www.acdlabs.com/resource/an-assessment-of-the-ocular-toxicity-of-two-major-sources-of-environmental-exposure/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/an-assessment-of-the-ocular-toxicity-of-two-major-sources-of-environmental-exposure/" class="content"> <h4>An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure</h4> <p>This article discusses, in part, how ADME and Tox Suite were used to apply in silico methods to detect the ocular irritation response to air contaminants.</p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/an-assessment-of-the-ocular-toxicity-of-two-major-sources-of-environmental-exposure/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item articles color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-signature"></i>Articles</span> <a target="_blank" href="https://www.acdlabs.com/resource/toxicity-of-minoxidil-comprehensive-in-silico-prediction-of-main-toxicity-endpoints-acute-toxicity-irritation-of-skin-and-eye-genetic-toxicity-health-effect-cardiotoxicity-and-endocrine-sys/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/toxicity-of-minoxidil-comprehensive-in-silico-prediction-of-main-toxicity-endpoints-acute-toxicity-irritation-of-skin-and-eye-genetic-toxicity-health-effect-cardiotoxicity-and-endocrine-sys/" class="content"> <h4>Toxicity of Minoxidil&mdash;Comprehensive in Silico Prediction of Main Toxicity Endpoints: Acute Toxicity, Irritation of Skin and Eye, Genetic Toxicity, Health Effect, Cardiotoxicity and Endocrine System Disruption</h4> <p>This article focusses on elucidating the toxicological profile of minoxidil, a widely used pharmacological agent for alopecia, through the application of in silico methods using Tox Suite.</p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/toxicity-of-minoxidil-comprehensive-in-silico-prediction-of-main-toxicity-endpoints-acute-toxicity-irritation-of-skin-and-eye-genetic-toxicity-health-effect-cardiotoxicity-and-endocrine-sys/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item articles color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-signature"></i>Articles</span> <a target="_blank" href="https://www.acdlabs.com/resource/1-nitropyrene-metabolism-and-health-risk-identification-of-key-enzymes-pathways-and-metabolites-using-a-multimethod-approach/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/1-nitropyrene-metabolism-and-health-risk-identification-of-key-enzymes-pathways-and-metabolites-using-a-multimethod-approach/" class="content"> <h4>1-Nitropyrene Metabolism and Health Risk: Identification of Key Enzymes, Pathways, and Metabolites Using a Multimethod Approach</h4> <p>Polycyclic aromatic hydrocarbon (PAH) derivatives have a widespread presence in the environment, but their metabolism and potential risk remain unclear. In this study, we used molecular dynamics simulations and density functional theory to calculate the metabolic mechanism of 1-nitropyrene (1-NP), an important PAH derivative. ACD/Percepta database was used to screen the major metabolic enzymes that metabolize 1-NP.</p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/1-nitropyrene-metabolism-and-health-risk-identification-of-key-enzymes-pathways-and-metabolites-using-a-multimethod-approach/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item articles color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-signature"></i>Articles</span> <a target="_blank" href="https://doi.org/10.1016/j.tox.2022.153412" class="content"> <a target="_blank" href="https://doi.org/10.1016/j.tox.2022.153412" class="content"> <h4>Prediction of Drug-induced Mitochondrial Dysfunction Using Succinate-cytochrome C Reductase Activity, Qsar and Molecular Docking</h4> <p>This article highlights the use of the Percepta Platform to calculate various molecular and physicochemical descriptors used by the authors of the article.</p> </a> <a class="arrow" target="_blank" href="https://doi.org/10.1016/j.tox.2022.153412"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item presentations color-orange"> <div class="card"> <span class="badge"><i class="fas fa-presentation"></i>Presentations</span> <a href="https://www.acdlabs.com/resource/introduction-to-using-qsar-for-the-assessment-of-potential-mutagenicity-of-drug-impurities-under-ich-m7/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/introduction-to-using-qsar-for-the-assessment-of-potential-mutagenicity-of-drug-impurities-under-ich-m7/" class="content"> <h4>Introduction to Using (Q)SAR for the Assessment of Potential Mutagenicity of Drug Impurities Under ICH M7</h4>E. Fioravanzo, ToxNavigation <p><p>This presentation explains the fundamentals of computational toxicology as a critical aspect of modern impurities control.</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/introduction-to-using-qsar-for-the-assessment-of-potential-mutagenicity-of-drug-impurities-under-ich-m7/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item blog color-orange"> <div class="card"> <span class="badge"><i class="fas fa-comment-alt"></i>Blog</span> <a href="https://www.acdlabs.com/blog/5-things-you-need-to-stop-doing-in-your-lab-gain-time-and-be-awesome-at-your-job/" class="content"> <a target="_blank" href="https://www.acdlabs.com/blog/5-things-you-need-to-stop-doing-in-your-lab-gain-time-and-be-awesome-at-your-job/" class="content"> <h4>5 things you need to STOP doing in your lab | Gain time and be awesome at your job</h4> <p><p>There just doesn&#8217;t seem to be enough hours in the day to get everything done. There are ways to gain time and be able to do more but they can be difficult to identify because until we’re exposed to them we carry on as we always have. If you are still doing any of the things discussed here, then there are ways you can gain hours in your day and even do your job better than you are right now!</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/blog/5-things-you-need-to-stop-doing-in-your-lab-gain-time-and-be-awesome-at-your-job/"><i class="far fa-arrow-right"></i></a> </div> </div> </div> </div> </section><section class="demo-cta form-color-orange" id="contact-us" data-menu="Contact Us" data-magellan-target="contact-us"> <div class="anchor"><span id="product_demo"></span></div> <div class="background" style="background-image: url(https://www.acdlabs.com/wp-content/uploads/2022/07/contact-cta-percepta-scaled.jpg)"></div> <div class="grid-container"> <div class="grid-x align-center"> <div class="cell medium-8 large-5"> <script data-jetpack-boost="ignore" type="text/javascript"></script> <div class='gf_browser_chrome gform_wrapper gravity-theme gform-theme--no-framework' data-form-theme='gravity-theme' data-form-index='0' id='gform_wrapper_3' style='display:none'><div id='gf_3' class='gform_anchor' tabindex='-1'></div><form method='post' enctype='multipart/form-data' target='gform_ajax_frame_3' id='gform_3' action='/products/percepta-platform/tox-suite/#gf_3' data-formid='3' novalidate> <div class='gform-body gform_body'><div id='gform_fields_3' class='gform_fields top_label form_sublabel_below description_below validation_below'><div id="field_3_6" class="gfield gfield--type-text gfield--input-type-text gfield--width-full field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_hidden" data-js-reload="field_3_6" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_3_6'>Demo Request For:</label><div class='ginput_container ginput_container_text'><input name='input_6' id='input_3_6' type='text' value='Tox Suite' class='large' aria-invalid="false" /> </div></div><div id="field_3_2" class="gfield gfield--type-html gfield--input-type-html gfield--width-full gfield_html gfield_html_formatted gfield_no_follows_desc field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_3_2" ><h3>Request a Consultation & Demo</h3> <p>Contact us to arrange for a demonstration of our software, or to get answers to any questions you may have.</p></div><fieldset id="field_3_7" class="gfield gfield--type-name gfield--input-type-name gfield--width-full gfield_contains_required field_sublabel_hidden_label gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_7" ><legend class='gfield_label gform-field-label gfield_label_before_complex' >Name<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></legend><div class='ginput_complex ginput_container ginput_container--name no_prefix has_first_name no_middle_name has_last_name no_suffix gf_name_has_2 ginput_container_name gform-grid-row' id='input_3_7'> <span id='input_3_7_3_container' class='name_first gform-grid-col gform-grid-col--size-auto' > <input type='text' name='input_7.3' id='input_3_7_3' value='' aria-required='true' placeholder='First Name*' /> <label for='input_3_7_3' class='gform-field-label gform-field-label--type-sub hidden_sub_label screen-reader-text'>First</label> </span> <span id='input_3_7_6_container' class='name_last gform-grid-col gform-grid-col--size-auto' > <input type='text' name='input_7.6' id='input_3_7_6' value='' aria-required='true' placeholder='Last Name*' /> <label for='input_3_7_6' class='gform-field-label gform-field-label--type-sub hidden_sub_label screen-reader-text'>Last</label> </span> </div></fieldset><div id="field_3_3" class="gfield gfield--type-email gfield--input-type-email gfield--width-half gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_3" ><label class='gfield_label gform-field-label' for='input_3_3'>Email<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_email'> <input name='input_3' id='input_3_3' type='email' value='' class='large' placeholder='Email*' aria-required="true" aria-invalid="false" /> </div></div><div id="field_3_8" class="gfield gfield--type-text gfield--input-type-text gfield--width-half gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_8" ><label class='gfield_label gform-field-label' for='input_3_8'>Company<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_text'><input name='input_8' id='input_3_8' type='text' value='' class='large' placeholder='Company*' aria-required="true" aria-invalid="false" /> </div></div><div id="field_3_9" class="gfield gfield--type-select gfield--input-type-select gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_9" ><label class='gfield_label gform-field-label' for='input_3_9'>Country<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_select'><select name='input_9' id='input_3_9' class='large gfield_select' aria-required="true" aria-invalid="false" ><option value='' selected='selected' class='gf_placeholder'>Country*</option><option value='Afghanistan' >Afghanistan</option><option value='Albania' >Albania</option><option value='Algeria' >Algeria</option><option value='American Samoa' >American Samoa</option><option value='Andorra' >Andorra</option><option value='Angola' >Angola</option><option value='Anguilla' >Anguilla</option><option value='Antarctica' >Antarctica</option><option value='Antigua and Barbuda' >Antigua and Barbuda</option><option value='Argentina' >Argentina</option><option value='Armenia' >Armenia</option><option value='Aruba' >Aruba</option><option value='Australia' >Australia</option><option value='Austria' >Austria</option><option value='Azerbaijan' >Azerbaijan</option><option value='Bahamas' >Bahamas</option><option value='Bahrain' >Bahrain</option><option value='Bangladesh' >Bangladesh</option><option value='Barbados' >Barbados</option><option value='Belarus' >Belarus</option><option value='Belgium' >Belgium</option><option value='Belize' >Belize</option><option value='Benin' >Benin</option><option value='Bermuda' >Bermuda</option><option value='Bhutan' >Bhutan</option><option value='Bolivia' >Bolivia</option><option value='Bosnia and Herzegovina' >Bosnia and Herzegovina</option><option value='Botswana' >Botswana</option><option value='Bouvet Island' >Bouvet Island</option><option value='Brazil' >Brazil</option><option value='British Indian Ocean Territory' >British Indian Ocean Territory</option><option value='Brunei Darussalam' >Brunei Darussalam</option><option value='Bulgaria' >Bulgaria</option><option value='Burkina Faso' >Burkina Faso</option><option value='Burundi' >Burundi</option><option value='Cambodia' >Cambodia</option><option value='Cameroon' >Cameroon</option><option value='Canada' >Canada</option><option value='Cape Verde' >Cape Verde</option><option value='Cayman Islands' >Cayman Islands</option><option value='Central African Republic' >Central African Republic</option><option value='Chad' >Chad</option><option value='Chile' >Chile</option><option value='China' >China</option><option value='Christmas Island' >Christmas Island</option><option value='Cocos (Keeling) Islands' >Cocos (Keeling) Islands</option><option value='Colombia' >Colombia</option><option value='Comoros' >Comoros</option><option value='Congo' >Congo</option><option value='Congo, The Democratic Republic of the' >Congo, The Democratic Republic of the</option><option value='Cook Islands' >Cook Islands</option><option value='Costa Rica' >Costa Rica</option><option value='Croatia' >Croatia</option><option value='Cuba' >Cuba</option><option value='Curaçao' >Curaçao</option><option value='Cyprus' >Cyprus</option><option value='Czech Republic' >Czech Republic</option><option value='Cote d&#039;Ivoire' >Cote d&#039;Ivoire</option><option value='Denmark' >Denmark</option><option value='Djibouti' >Djibouti</option><option value='Dominica' >Dominica</option><option value='Dominican Republic' >Dominican Republic</option><option value='East Timor' >East Timor</option><option value='Ecuador' >Ecuador</option><option value='Egypt' >Egypt</option><option value='El Salvador' >El Salvador</option><option value='Equatorial Guinea' >Equatorial Guinea</option><option value='Eritrea' >Eritrea</option><option value='Estonia' >Estonia</option><option value='Ethiopia' >Ethiopia</option><option value='Falkland Islands (Malvinas)' >Falkland Islands (Malvinas)</option><option value='Faroe Islands' >Faroe Islands</option><option value='Fiji' >Fiji</option><option value='Finland' >Finland</option><option value='France' >France</option><option value='French Guiana' >French Guiana</option><option value='French Polynesia' >French Polynesia</option><option value='French Southern Territories' >French Southern Territories</option><option value='Gabon' >Gabon</option><option value='Gambia' >Gambia</option><option value='Georgia' >Georgia</option><option value='Germany' >Germany</option><option value='Ghana' >Ghana</option><option value='Gibraltar' >Gibraltar</option><option value='Greece' >Greece</option><option value='Greenland' >Greenland</option><option value='Grenada' >Grenada</option><option value='Guadeloupe' >Guadeloupe</option><option value='Guam' >Guam</option><option value='Guatemala' >Guatemala</option><option value='Guernsey' >Guernsey</option><option value='Guinea' >Guinea</option><option value='Guinea-Bissau' >Guinea-Bissau</option><option value='Guyana' >Guyana</option><option value='Haiti' >Haiti</option><option value='Heard Island and McDonald Islands' >Heard Island and McDonald Islands</option><option value='Holy See (Vatican City)' >Holy See (Vatican City)</option><option value='Honduras' >Honduras</option><option value='Hong Kong' >Hong Kong</option><option value='Hungary' >Hungary</option><option value='Iceland' >Iceland</option><option value='India' >India</option><option value='Indonesia' >Indonesia</option><option value='Iran' >Iran</option><option value='Iraq' >Iraq</option><option value='Ireland' >Ireland</option><option value='Isle of Man' >Isle of Man</option><option value='Israel' >Israel</option><option value='Italy' >Italy</option><option value='Jamaica' >Jamaica</option><option value='Japan' >Japan</option><option value='Jersey' >Jersey</option><option value='Jordan' >Jordan</option><option value='Kazakhstan' >Kazakhstan</option><option value='Kenya' >Kenya</option><option value='Kiribati' >Kiribati</option><option value='Kuwait' >Kuwait</option><option value='Kyrgyzstan' >Kyrgyzstan</option><option value='Laos' >Laos</option><option value='Latvia' >Latvia</option><option value='Lebanon' >Lebanon</option><option value='Lesotho' >Lesotho</option><option value='Liberia' >Liberia</option><option value='Libya' >Libya</option><option value='Liechtenstein' >Liechtenstein</option><option value='Lithuania' >Lithuania</option><option value='Luxembourg' >Luxembourg</option><option value='Macau' >Macau</option><option value='Macedonia' >Macedonia</option><option value='Madagascar' >Madagascar</option><option value='Malawi' >Malawi</option><option value='Malaysia' >Malaysia</option><option value='Maldives' >Maldives</option><option value='Mali' >Mali</option><option value='Malta' >Malta</option><option value='Marshall Islands' >Marshall Islands</option><option value='Martinique' >Martinique</option><option value='Mauritania' >Mauritania</option><option value='Mauritius' >Mauritius</option><option value='Mayotte' >Mayotte</option><option value='Mexico' >Mexico</option><option value='Micronesia, Federated States of' >Micronesia, Federated States of</option><option value='Moldova' >Moldova</option><option value='Monaco' >Monaco</option><option value='Mongolia' >Mongolia</option><option value='Montenegro' >Montenegro</option><option value='Montserrat' >Montserrat</option><option value='Morocco' >Morocco</option><option value='Mozambique' >Mozambique</option><option value='Myanmar' >Myanmar</option><option value='Namibia' >Namibia</option><option value='Nauru' >Nauru</option><option value='Nepal' >Nepal</option><option value='Netherlands' >Netherlands</option><option value='New Caledonia' >New Caledonia</option><option value='New Zealand' >New Zealand</option><option value='Nicaragua' >Nicaragua</option><option value='Niger' >Niger</option><option value='Nigeria' >Nigeria</option><option value='Niue' >Niue</option><option value='Norfolk Island' >Norfolk Island</option><option value='North Korea' >North Korea</option><option value='Northern Mariana Islands' >Northern Mariana Islands</option><option value='Norway' >Norway</option><option value='Oman' >Oman</option><option value='Pakistan' >Pakistan</option><option value='Palau' >Palau</option><option value='Palestine' >Palestine</option><option value='Panama' >Panama</option><option value='Papua New Guinea' >Papua New Guinea</option><option value='Paraguay' >Paraguay</option><option value='Peru' >Peru</option><option value='Philippines' >Philippines</option><option value='Pitcairn Islands' >Pitcairn Islands</option><option value='Poland' >Poland</option><option value='Portugal' >Portugal</option><option value='Puerto Rico' >Puerto Rico</option><option value='Qatar' >Qatar</option><option value='Romania' >Romania</option><option value='Russia' >Russia</option><option value='Rwanda' >Rwanda</option><option value='Reunion' >Reunion</option><option value='Saint Barthélemy' >Saint Barthélemy</option><option value='Saint Helena' >Saint Helena</option><option value='Saint Kitts and Nevis' >Saint Kitts and Nevis</option><option value='Saint Lucia' >Saint Lucia</option><option value='Saint Martin' >Saint Martin</option><option value='Saint Pierre and Miquelon' >Saint Pierre and Miquelon</option><option value='Saint Vincent and the Grenadines' >Saint Vincent and the Grenadines</option><option value='Samoa' >Samoa</option><option value='San Marino' >San Marino</option><option value='Sao Tome and Principe' >Sao Tome and Principe</option><option value='Saudi Arabia' >Saudi Arabia</option><option value='Senegal' >Senegal</option><option value='Serbia' >Serbia</option><option value='Seychelles' >Seychelles</option><option value='Sierra Leone' >Sierra Leone</option><option value='Singapore' >Singapore</option><option value='Sint Maarten' >Sint Maarten</option><option value='Slovakia' >Slovakia</option><option value='Slovenia' >Slovenia</option><option value='Solomon Islands' >Solomon Islands</option><option value='Somalia' >Somalia</option><option value='South Africa' >South Africa</option><option value='South Georgia and The South Sandwich Islands' >South Georgia and The South Sandwich Islands</option><option value='South Korea' >South Korea</option><option value='South Sudan' >South Sudan</option><option value='Spain' >Spain</option><option value='Sri Lanka' >Sri Lanka</option><option value='Sudan' >Sudan</option><option value='Suriname' >Suriname</option><option value='Svalbard and Jan Mayen' >Svalbard and Jan Mayen</option><option value='Swaziland' >Swaziland</option><option value='Sweden' >Sweden</option><option value='Switzerland' >Switzerland</option><option value='Syria' >Syria</option><option value='Taiwan' >Taiwan</option><option value='Tajikistan' >Tajikistan</option><option value='Tanzania, United Republic of' >Tanzania, United Republic of</option><option value='Thailand' >Thailand</option><option value='Togo' >Togo</option><option value='Tokelau' >Tokelau</option><option value='Tonga' >Tonga</option><option value='Trinidad and Tobago' >Trinidad and Tobago</option><option value='Tunisia' >Tunisia</option><option value='Turkey' >Turkey</option><option value='Turkmenistan' >Turkmenistan</option><option value='Turks and Caicos Islands' >Turks and Caicos Islands</option><option value='Tuvalu' >Tuvalu</option><option value='United States Minor Outlying Islands' >United States Minor Outlying Islands</option><option value='Uganda' >Uganda</option><option value='Ukraine' >Ukraine</option><option value='United Arab Emirates' >United Arab Emirates</option><option value='United Kingdom' >United Kingdom</option><option value='United States' >United States</option><option value='Uruguay' >Uruguay</option><option value='Uzbekistan' >Uzbekistan</option><option value='Vanuatu' >Vanuatu</option><option value='Venezuela' >Venezuela</option><option value='Viet Nam' >Viet Nam</option><option value='Virgin Islands, British' >Virgin Islands, British</option><option value='Virgin Islands, U.S.' >Virgin Islands, U.S.</option><option value='Wallis and Futuna' >Wallis and Futuna</option><option value='Western Sahara' >Western Sahara</option><option value='Yemen' >Yemen</option><option value='Zambia' >Zambia</option><option value='Zimbabwe' >Zimbabwe</option></select></div></div><div id="field_3_11" class="gfield gfield--type-select gfield--input-type-select gfield--width-half gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_11" ><label class='gfield_label gform-field-label' for='input_3_11'>Province/State (CAN)<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_select'><select name='input_11' id='input_3_11' class='large gfield_select' aria-required="true" aria-invalid="false" ><option value='' selected='selected' class='gf_placeholder'>Province/State*</option><option value='Alberta' >Alberta</option><option value='British Columbia' >British Columbia</option><option value='Manitoba' >Manitoba</option><option value='New Brunswick' >New Brunswick</option><option value='Newfoundland and Labrador' >Newfoundland and Labrador</option><option value='Northwest Territories' >Northwest Territories</option><option value='Nova Scotia' >Nova Scotia</option><option value='Nunavut' >Nunavut</option><option value='Ontario' >Ontario</option><option value='Prince Edward Island' >Prince Edward Island</option><option value='Quebec' >Quebec</option><option value='Saskatchewan' >Saskatchewan</option><option value='Yukon' >Yukon</option></select></div></div><div id="field_3_12" class="gfield gfield--type-select gfield--input-type-select gfield--width-half field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_12" ><label class='gfield_label gform-field-label' for='input_3_12'>Province/State (US)</label><div class='ginput_container ginput_container_select'><select name='input_12' id='input_3_12' class='large gfield_select' aria-invalid="false" ><option value='' selected='selected' class='gf_placeholder'>Province/State*</option><option value='Alabama' >Alabama</option><option value='Alaska' >Alaska</option><option value='Arizona' >Arizona</option><option value='Arkansas' >Arkansas</option><option value='California' 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Not consenting or withdrawing consent, may adversely affect certain features and functions.</div> <!-- categories start --> <div class="cmplz-categories"> <details class="cmplz-category cmplz-functional" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Functional</span> <span class='cmplz-always-active'> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-functional-optout" data-category="cmplz_functional" class="cmplz-consent-checkbox cmplz-functional" size="40" value="1"/> <label class="cmplz-label" for="cmplz-functional-optout" tabindex="0"><span class="screen-reader-text">Functional</span></label> </span> Always active </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-functional">The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.</span> </div> </details> <details class="cmplz-category cmplz-preferences" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Preferences</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-preferences-optout" data-category="cmplz_preferences" class="cmplz-consent-checkbox cmplz-preferences" size="40" value="1"/> <label class="cmplz-label" for="cmplz-preferences-optout" tabindex="0"><span class="screen-reader-text">Preferences</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-preferences">The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.</span> </div> </details> <details class="cmplz-category cmplz-statistics" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Statistics</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-statistics-optout" data-category="cmplz_statistics" class="cmplz-consent-checkbox cmplz-statistics" size="40" value="1"/> <label class="cmplz-label" for="cmplz-statistics-optout" tabindex="0"><span class="screen-reader-text">Statistics</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-statistics">The technical storage or access that is used exclusively for statistical purposes.</span> <span class="cmplz-description-statistics-anonymous">The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.</span> </div> </details> <details class="cmplz-category cmplz-marketing" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Marketing</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-marketing-optout" data-category="cmplz_marketing" class="cmplz-consent-checkbox cmplz-marketing" size="40" value="1"/> <label class="cmplz-label" for="cmplz-marketing-optout" tabindex="0"><span class="screen-reader-text">Marketing</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-marketing">The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.</span> </div> </details> </div><!-- categories end --> </div> <div class="cmplz-links cmplz-information"> <a class="cmplz-link cmplz-manage-options cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">Manage options</a> <a class="cmplz-link cmplz-manage-third-parties cookie-statement" href="#" data-relative_url="#cmplz-cookies-overview">Manage services</a> <a class="cmplz-link cmplz-manage-vendors tcf cookie-statement" href="#" data-relative_url="#cmplz-tcf-wrapper">Manage {vendor_count} vendors</a> <a class="cmplz-link cmplz-external cmplz-read-more-purposes tcf" target="_blank" rel="noopener noreferrer nofollow" href="https://cookiedatabase.org/tcf/purposes/">Read more about these purposes</a> </div> <div class="cmplz-divider cmplz-footer"></div> <div class="cmplz-buttons"> <button class="cmplz-btn cmplz-accept">Accept</button> <button class="cmplz-btn cmplz-deny">Deny</button> <button class="cmplz-btn cmplz-view-preferences">View preferences</button> <button class="cmplz-btn cmplz-save-preferences">Save preferences</button> <a class="cmplz-btn cmplz-manage-options tcf cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">View preferences</a> </div> <div class="cmplz-links cmplz-documents"> <a class="cmplz-link cookie-statement" href="#" data-relative_url="">{title}</a> <a class="cmplz-link privacy-statement" href="#" data-relative_url="">{title}</a> <a class="cmplz-link impressum" href="#" data-relative_url="">{title}</a> </div> </div> </div> <div id="cmplz-manage-consent" data-nosnippet="true"><button class="cmplz-btn cmplz-hidden cmplz-manage-consent manage-consent-1">Manage consent</button> <button class="cmplz-btn cmplz-hidden cmplz-manage-consent manage-consent-1">Manage consent</button> </div> <noscript><link rel='stylesheet' id='all-css-8c77a39f9423a48e23ed643d94442b61' href='https://www.acdlabs.com/_jb_static/??-eJylzDEOwjAMheHbMNFaBomyVJylNaZYxHEUp1TcniAEExPd3vD+D5bUkMXCsUAK8yTRYTEjU+VMDIM7FwcK8nqMwehWD9S8V0vuW/hBTHm4S3lcLKt/DXc4i1dlcKFWJf6Xlysr10STxRr5WkkYcaXxyU/aY7ffIR4P2G1o7PEJT6eEiQ==' type='text/css' media='all' /></noscript><link rel='stylesheet' id='all-css-8c77a39f9423a48e23ed643d94442b61' href='https://www.acdlabs.com/_jb_static/??-eJylzDEOwjAMheHbMNFaBomyVJylNaZYxHEUp1TcniAEExPd3vD+D5bUkMXCsUAK8yTRYTEjU+VMDIM7FwcK8nqMwehWD9S8V0vuW/hBTHm4S3lcLKt/DXc4i1dlcKFWJf6Xlysr10STxRr5WkkYcaXxyU/aY7ffIR4P2G1o7PEJT6eEiQ==' type='text/css' media="not all" data-media="all" onload="this.media=this.dataset.media; 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