Search results for: pyrimidines

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pyrimidines</title> <meta name="description" content="Search results for: pyrimidines"> <meta name="keywords" content="pyrimidines"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="pyrimidines"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: pyrimidines</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Molecular Design and Synthesis of Heterocycles Based Anticancer Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amna%20J.%20Ghith">Amna J. Ghith</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Abu%20Zid"> Khaled Abu Zid</a>, <a href="https://publications.waset.org/abstracts/search?q=Khairia%20Youssef"> Khairia Youssef</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasser%20Saad"> Nasser Saad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Backgrounds: The multikinase and vascular endothelial growth factor (VEGF) receptor inhibitors interrupt the pathway by which angiogenesis becomes established and promulgated, resulting in the inadequate nourishment of metastatic disease. VEGFR-2 has been the principal target of anti-angiogenic therapies. We disclose the new thieno pyrimidines as inhibitors of VEGFR-2 designed by a molecular modeling approach with increased synergistic activity and decreased side effects. Purpose: 2-substituted thieno pyrimidines are designed and synthesized with anticipated anticancer activity based on its in silico molecular docking study that supports the initial pharmacophoric hypothesis with a same binding mode of interaction at the ATP-binding site of VEGFR-2 (PDB 2QU5) with high docking score. Methods: A series of compounds were designed using discovery studio 4.1/CDOCKER with a rational that mimic the pharmacophoric features present in the reported active compounds that targeted VEGFR-2. An in silico ADMET study was also performed to validate the bioavailability of the newly designed compounds. Results: The Compounds to be synthesized showed interaction energy comparable to or within the range of the benzimidazole inhibitor ligand when docked with VEGFR-2. ADMET study showed comparable results most of the compounds showed absorption within (95-99) zone varying according to different substitutions attached to thieno pyrimidine ring system. Conclusions: A series of 2-subsituted thienopyrimidines are to be synthesized with anticipated anticancer activity and according to docking study structure requirement for the design of VEGFR-2 inhibitors which can act as powerful anticancer agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=docking" title="docking">docking</a>, <a href="https://publications.waset.org/abstracts/search?q=discovery%20studio%C2%A04.1%2FCDOCKER" title=" discovery studio聽4.1/CDOCKER"> discovery studio聽4.1/CDOCKER</a>, <a href="https://publications.waset.org/abstracts/search?q=heterocycles%20based%20anticancer%20agents" title=" heterocycles based anticancer agents"> heterocycles based anticancer agents</a>, <a href="https://publications.waset.org/abstracts/search?q=2-subsituted%20thienopyrimidines" title=" 2-subsituted thienopyrimidines"> 2-subsituted thienopyrimidines</a> </p> <a href="https://publications.waset.org/abstracts/53080/molecular-design-and-synthesis-of-heterocycles-based-anticancer-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53080.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">246</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Microwave-Assisted Synthesis of a Class of Pyridine and Purine Thioglycoside Analogs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mamdouh%20Abu-Zaied">Mamdouh Abu-Zaied</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Mohamed"> K. Mohamed</a>, <a href="https://publications.waset.org/abstracts/search?q=Galal%20A.%20Nawwar"> Galal A. Nawwar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microwave-assisted synthesis of a new class of pyridine or purine thioglycoside analogs from readily available starting materials has been described. The key step of this protocol is the formation of sodium pyridine 4-thiolate 4 and pyrazolo[1,5-a]pyrimidine-7-thiolate 5 derivatives via condensation of 1 with cyanoacetanilide derivative 2 or 5-aminopyrazole derivative 3 respectively under microwave irradiation, followed by coupling with halo sugars to give the corresponding pyridine and purine thioglycoside analogs. The obtained compounds were evaluated in vitro against lung (A549), colon (HCT116), liver (HEPG2), and MCF-7(breast) cancer cell lines. Some of them recorded promising activities. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antitumor" title="antitumor">antitumor</a>, <a href="https://publications.waset.org/abstracts/search?q=cyclic%20sugars" title=" cyclic sugars"> cyclic sugars</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrazoles" title=" pyrazoles"> pyrazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=pyridines" title=" pyridines"> pyridines</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrimidines" title=" pyrimidines"> pyrimidines</a>, <a href="https://publications.waset.org/abstracts/search?q=purines" title=" purines"> purines</a>, <a href="https://publications.waset.org/abstracts/search?q=thioglycosides" title=" thioglycosides"> thioglycosides</a> </p> <a href="https://publications.waset.org/abstracts/61036/microwave-assisted-synthesis-of-a-class-of-pyridine-and-purine-thioglycoside-analogs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61036.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">241</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div 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Search results for: pyrimidines