RJPT - Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software

<!DOCTYPE html> <html> <head><meta charset="utf-8" /><meta http-equiv="X-UA-Compatible" content="IE=edge" />  <meta name="viewport" content="width=device-width, initial-scale=1" />  <title> RJPT - Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software </title><link href="css1/bootstrap.min.css" rel="stylesheet" />  <link href="fonts/css/font-awesome.min.css" rel="stylesheet" />  <link href="https://fonts.googleapis.com/css?family=Lato:400,300,400italic,700,900,700italic" rel="stylesheet" type="text/css" /><link href="https://fonts.googleapis.com/css?family=Roboto:500" rel="stylesheet" type="text/css" />  <link rel="stylesheet" href="css1/slicknav.css" />  <link href="rs-plugin/css/settings.css" rel="stylesheet" />  <link href="css1/owl.carousel.css" rel="stylesheet" />  <link href="style.css" rel="stylesheet" />  <link href="css1/responsive.css" rel="stylesheet" /><meta name="msapplication-TileColor" content="#ffffff" /><meta name="msapplication-TileImage" content="f_icon/ms-icon-144x144.png" /><meta name="theme-color" content="#ffffff" /> <script type="text/javascript" src="https://d3mkw6s8thqya7.cloudfront.net/integration-plugin.js" id="aisensy-wa-widget" widget-id="XFmHWJ" > </script> <meta name="Description" content="Aloin is an anthraquinone glycoside with high-volume applications in food and pharmaceutical products. In this work use of polyvinyl alcohol was first used, as per previous work mentioned inthe literature to dissolve the aloin molecule while entrapping it poly (D, L-lactide-co-glycolide) PLGA, the study investigates the aloin nanoparticles by using an important tool of drug design software stat expert 13 version. The nanoprecipitation process is used for Aloin nanoparticle formulation by involving PLGA polymer and optimizing the formulation by central composite (CC) design of response surface. The experiment was designed using four criteria, as described in the article, and two factors were investigated to improve the size of particles and (EE) entangled efficiency of drug aloin. The optimal formulation of the drug was characterized by various parameters involving Scanning, transmission Microscopy i.e. (SEM-TEM), and in vitro release parameters. With a zero-order release parameter, the formulation had an EE of drug 98.06% and a drug particle size of 98.5nm. The result of aloin nanoformulation with the help of statistical experimental design demonstrates that the optimized aloin formulation of nanoparticles improves the bioavailability and the process variables to achieve a favorable result." /><meta http-equiv="Content-Type" content="text/html; charset=utf-8" /><meta name="citation_title" content="Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software" /><meta name="citation_author" content="Rishika Chauhan" /><meta name="citation_author" content="Anuj Malik" /><meta name="citation_publication_date" content="2025/01/27" /><meta name="citation_date" content="2025/01/27" /><meta name="citation_journal_title" content="Research Journal of Pharmacy and Technology" /><meta name="citation_volume" content="18" /><meta name="citation_issue" content="1" /><meta name="citation_firstpage" content="266" /><meta name="citation_lastpage" content="272" /><meta name="citation_abstract_pdf_url" content="https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-41" /><meta name="citation_html_url" content="https://rjptonline.org/HTMLPaper.aspx?Journal=Research Journal of Pharmacy and Technology;PID=2025-18-1-41" /><meta name="citation_abstract_html_url" content="https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-41" /><meta name="citation_publisher" content="Research Journal of Pharmacy and Technology" /><meta name="citation_issn_print" content="0974-3618" /><meta name="citation_issn_online" content="0974-360X" /><meta name="citation_language" content="English" /><meta name="citation_keywords" content="Central composite design statistical design; Aloin; Controlled release; PLGA; Nanoprecipitation method; SEM ; pharmaceutical; L-lactide-co-glycolide); nanoprecipitation; nanoformulation; bioavailability" /><meta name="citation_doi" content="10.52711/0974-360X.2025.00041" /></head> <body> <form method="post" 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WFsaWsuIFByZXBhcmF0aW9uIG9mIERydWcgQWxvaW4gTmFub3BhcnRpY2xlcyBmb3IgRW5oYW5jZWQgQmlvYXZhaWxhYmlsaXR5IGFuZCBPcHRpbWl6YXRpb24gYnkgdXNpbmcgYSBEcnVnIERlc2lnbiBTdGF0LWVhc2Ugc29mdHdhcmUuIFJlc2VhcmNoIEpvdXJuYWwgb2YgUGhhcm1hY3kgYW5kIFRlY2hub2xvZ3kuIDIwMjU7MTgoMSk6MjY2LTIuIGRvaTogMTAuNTI3MTEvMDk3NC0zNjBYLjIwMjUuMDAwNDFkZAIdDw8WAh8CBc4CUmlzaGlrYSBDaGF1aGFuLCBBbnVqIE1hbGlrLiBQcmVwYXJhdGlvbiBvZiBEcnVnIEFsb2luIE5hbm9wYXJ0aWNsZXMgZm9yIEVuaGFuY2VkIEJpb2F2YWlsYWJpbGl0eSBhbmQgT3B0aW1pemF0aW9uIGJ5IHVzaW5nIGEgRHJ1ZyBEZXNpZ24gU3RhdC1lYXNlIHNvZnR3YXJlLiBSZXNlYXJjaCBKb3VybmFsIG9mIFBoYXJtYWN5IGFuZCBUZWNobm9sb2d5LiAyMDI1OzE4KDEpOjI2Ni0yLiBkb2k6IDEwLjUyNzExLzA5NzQtMzYwWC4yMDI1LjAwMDQxICZuYnNwOyBBdmFpbGFibGUgb246IGh0dHBzOi8vcmpwdG9ubGluZS5vcmcvQWJzdHJhY3RWaWV3LmFzcHg/UElEPTIwMjUtMTgtMS00MWRkAh8PDxYCHwIF+GI8Yj44LiBSRUZFUkVOQ0U6IDwvYj48YnI+MS4mbmJzcDsmbmJzcDsmbmJzcDsgVmVua2F0ZXNoIEROLCBCYXNrYXJhbiBNLCBLYXJyaSBWViwgTWFubmVtYWxhIFNTLCBSYWRoYWtyaXNobmEgSywgR290aSBTLiBGYWJyaWNhdGlvbiBhbmQgaW4gdml2byBldmFsdWF0aW9uIG9mIG5lbGZpbmF2aXIgbG9hZGVkIFBMR0EgbmFub3BhcnRpY2xlcyBmb3IgZW5oYW5jaW5nIG9yYWwgYmlvYXZhaWxhYmlsaXR5IGFuZCB0aGVyYXBldXRpYyBlZmZlY3QuIFNhdWRpIFBoYXJtIEouIDIwMTU7IDIzKDYpOiA2NjctNzQuIGRvaTogMTAuMTAxNi9qLmpzcHMuMjAxNS4wMi4wMjEuPGJyPjIuJm5ic3A7Jm5ic3A7Jm5ic3A7IE1haW5hcmRlcyBSTSwgRXZhbmdlbGlzdGEgUkMuIFBMR0EgbmFub3BhcnRpY2xlcyBjb250YWluaW5nIHByYXppcXVhbnRlbDogZWZmZWN0IG9mIGZvcm11bGF0aW9uIHZhcmlhYmxlcyBvbiBzaXplIGRpc3RyaWJ1dGlvbi4gSW50IEogUGhhcm0uIDIwMDU7IDI5MCgxLTIpOiAxMzctNDQuIGRvaTogMTAuMTAxNi9qLmlqcGhhcm0uMjAwNC4xMS4wMjcuPGJyPjMuJm5ic3A7Jm5ic3A7Jm5ic3A7IE1vaGFucmFqIFZKLCBDaGVuIFkuIE5hbm9wYXJ0aWNsZXMtYSByZXZpZXcuIFRyb3BpY2FsIEpvdXJuYWwgb2YgUGhhcm1hY2V1dGljYWwgUmVzZWFyY2guIDIwMDY7IDUoMSk6IDU2MS03My4gRE9JOjEwLjQzMTQvdGpwci52NWkxLjE0NjM0PGJyPjQuJm5ic3A7Jm5ic3A7Jm5ic3A7IEthZGlhbiwgUi4g4oCcbmFub3BhcnRpY2xlczogYSBwcm9taXNpbmcgZHJ1ZyBkZWxpdmVyeSBhcHByb2FjaOKAnS4gQXNpYW4gSm91cm5hbCBvZiBQaGFybWFjZXV0aWNhbCBhbmQgQ2xpbmljYWwgUmVzZWFyY2guIDIwMTg7IEphbi4gMTEoMSk6IDMwLTM1LCBkb2k6MTAuMjIxNTkvYWpwY3IuMjAxOC52MTFpMS4yMjAzNS48YnI+NS4mbmJzcDsmbmJzcDsmbmJzcDsgQ2FuZGlvdGkgTFYsIERlIFphbiBNTSwgQ8OhbWFyYSBNUywgR29pY29lY2hlYSBIQy4gRXhwZXJpbWVudGFsIGRlc2lnbiBhbmQgbXVsdGlwbGUgcmVzcG9uc2Ugb3B0aW1pemF0aW9uLiBVc2luZyB0aGUgZGVzaXJhYmlsaXR5IGZ1bmN0aW9uIGluIGFuYWx5dGljYWwgbWV0aG9kcyBkZXZlbG9wbWVudC4gVGFsYW50YS4gMjAxNDsgSnVuIDE1OyAxMjQ6IDEyMy0zOC5odHRwczovL2RvaS5vcmcvMTAuMTAxNi9qLnRhbGFudGEuMjAxNC4wMS4wMzQ8YnI+Ni4mbmJzcDsmbmJzcDsmbmJzcDsgRXNtYXQgQVksIFRvbWFzZXR0byBDLCBSaW8gTSBDLiBDeXRvdG94aWNpdHkgb2YgYSBuYXR1cmFsIGFudGhyYXF1aW5vbmUgKGFsb2luKSBhZ2FpbnN0IGh1bWFuIGJyZWFzdCBjYW5jZXIgY2VsbCBsaW5lcyB3aXRoIGFuZCB3aXRob3V0IEVyYkIgMi10b3BvaXNvbWVyYXNlIElJzrEgYW1wbGlmaWNhdGlvbi4gQ2FuY2VyIEJpb2wgVGhlci4gMjAwNjsgNTogOTfigJMxMDMgRE9JOiAxMC40MTYxL2NidC41LjEuMjM0Nzxicj43LiZuYnNwOyZuYnNwOyZuYnNwOyBFbGkgSGFybGV2LCBFdmlhdGFyIE5ldm8sIEVwaHJhaW0gUC4gTGFuc2t5MSwgUml2a2EgT2ZpcjIsIEFudXBhbSBCaXNoYXllZS4gQW50aWNhbmNlciBQb3RlbnRpYWwgb2YgQWxvZXM6IEFudGlveGlkYW50LCBBbnRpcHJvbGlmZXJhdGl2ZSwgYW5kIEltbXVub3N0aW11bGF0b3J5IEF0dHJpYnV0ZXMgUGxhbnRhIE1lZCAyMDEyOyA3ODogODQz4oCTODUyIERPSTogMTAuMTA1NS9zLTAwMzEtMTI5ODQ1Mzxicj44LiZuYnNwOyZuYnNwOyZuYnNwOyBQYXJrLCBNLlkuLCBLd29uLCBILkouIGFuZCBTdW5nLCBNLksuIDIwMDhiLiBQbGFzbWEsIHRpc3N1ZSwgYW5kIHVyaW5hcnkgbGV2ZWxzIG9mIGFsb2luIGluIHJhdHMgYWZ0ZXIgdGhlIGFkbWluaXN0cmF0aW9uIG9mIHB1cmUgYWxvaW4uIE51dHJpdGlvbiBSZXNlYXJjaCBhbmQgUHJhY3RpY2UuIDI6IDE3LTIxLiBkb2k6IDEwLjQxNjIvbnJwLjIwMDguMi4xLjE3PGJyPjkuJm5ic3A7Jm5ic3A7Jm5ic3A7IFBhcmsgTVksIEt3b24gSEosIFN1bmcgTUsuIFBsYXNtYSwgdGlzc3VlIGFuZCB1cmluYXJ5IGxldmVscyBvZiBhbG9pbiBpbiByYXRzIGFmdGVyIHRoZSBhZG1pbmlzdHJhdGlvbiBvZiBwdXJlIGFsb2luLiBOdXRyIFJlcyBQcmFjdC4gMjAwODsgU3ByaW5nOyAyKDEpOiAxNy0yMS4gZG9pOiAxMC40MTYyL25ycC4yMDA4LjIuMS4xNy48YnI+MTAuJm5ic3A7Jm5ic3A7Jm5ic3A7IE1hIFksIFRhbmcgVCwgU2hlbmcgTCwgV2FuZyBaLCBUYW8gSCwgWmhhbmcgUSwgWmhhbmcgWSwgUWkgWi4gQWxvaW4gc3VwcHJlc3NlcyBsaXBvcG9seXNhY2NoYXJpZGUgaW5kdWNlZCBpbmZsYW1tYXRpb24gYnkgaW5oaWJpdGluZyBKQUsxIFNUQVQxLzMgYWN0aXZhdGlvbiBhbmQgUk9TIFByb2R1Y3Rpb24gaW4gUkFXMjY0LjcgY2VsbHMuIEludCBKIE1vbCBNZWQuIDIwMTg7IE9jdDsgNDIoNCk6IDE5MjUtMTkzNC4gZG9pOiAxMC4zODkyL2lqbW0uMjAxOC4zNzk2LiBFcHViIDIwMTggSnVsIDMxLjxicj4xMS4mbmJzcDsmbmJzcDsmbmJzcDsgUy4gU2l2YXByYXNhZCwgQ2guIFNhZGFrdmFsaSwgVi4gUmF2aSBLdW1hciwgUC5WLiBNdXJhbGkgS3Jpc2huYSwgU2hhaWsgTW9oYW1tZWQgWXVzdWYgLCBBLiBTcmlrYW50aC4gRm9ybXVsYXRpb24gYW5kIENoYXJhY3Rlcml6YXRpb24gb2YgVGVub2ZvdmlyIERpc3Byb3h5bCBGdW1lcmF0ZSBOYW5vcGFydGljbGVzIHByZXBhcmVkIGJ5IE5hbm9wcmVjaXBpdGF0aW9uIE1ldGhvZC4gUmVzZWFyY2ggSm91cm5hbCBvZiBQaGFybWFjeSBhbmQgVGVjaG5vbG9neS4gMjAyMjsgMTUoNyk6IDMwNzUtMCBET0k6IDEwLjUyNzExLzA5NzQtMzYwWC4yMDIyLjAwNTE0Ljxicj4xMi4mbmJzcDsmbmJzcDsmbmJzcDsgQmFkYW91aSBGWiwgQm91emlkIEQuIEZvcm11bGF0aW9uIGFuZCBPcHRpbWl6YXRpb24gb2YgRGljbG9mZW5hYyBTb2RpdW0gTG9hZGVkIEV0aHlsY2VsbHVsb3NlIE5hbm9wYXJ0aWNsZXMuIEJyYXppbGlhbiBKb3VybmFsIG9mIFBoYXJtYWNldXRpY2FsIFNjaWVuY2VzLiAyMDIyOyBKdW4gMjQ7IDU4LiBodHRwczovL2RvaS5vcmcvMTAuMTU5MC9zMjE3NS05NzkwMjAyMmUxOTU4Njxicj4xMy4mbmJzcDsmbmJzcDsmbmJzcDsgQ2lvY2lsdGV1IE1WLCBOaWNvbGFlc2N1IE9FLCBNb2NhbnUgQUcsIE5pY29saWNlc2N1IEMsIFJhdSBHLCBOZWFtdHUgSiwgQW16b2l1IEUsIEFtem9pdSBFLCBPYW5jZWEgQywgVHVyY3UtU3Rpb2xpY2EgYS4gUHJvY2VzcyBvcHRpbWl6YXRpb24gdXNpbmcgcXVhbGl0eSBieSBkZXNpZ24gKHFiZCkgYXBwcm9hY2ggb2YgYSBnZW50YW1pY2luIGxvYWRlZCBwbGdhIGJpb2NvbXBvc2l0ZS4gSm91cm5hbCBvZiBTY2llbmNlIGFuZCBBcnRzLiAyMDIxOyBPY3QgMTsgMjEoNCk6IDEwNjktODAuIERPSToxMC40NjkzOS9KLlNjaS5BcnRzLTIxLjQtYjAyPGJyPjE0LiZuYnNwOyZuYnNwOyZuYnNwOyBDb29wZXIgREwsIEhhcmlyZm9yb29zaCBTLiBEZXNpZ24gYW5kIG9wdGltaXphdGlvbiBvZiBQTEdBLWJhc2VkIGRpY2xvZmVuYWMgbG9hZGVkIG5hbm9wYXJ0aWNsZXMuIFBMb1MgT25lLiAyMDE0OyBKYW4gMjg7IDkoMSk6IGU4NzMyNi4gZG9pOiAxMC4xMzcxL2pvdXJuYWwucG9uZS4wMDg3MzI2Ljxicj4xNS4mbmJzcDsmbmJzcDsmbmJzcDsgVHVyayBDVCwgT3ogVUMsIFNlcmltIFRNLCBIYXNjaWNlayBDLiBGb3JtdWxhdGlvbiBhbmQgb3B0aW1pemF0aW9uIG9mIG5vbmlvbmljIHN1cmZhY3RhbnRzIGVtdWxzaWZpZWQgbmltZXN1bGlkZS1sb2FkZWQgUExHQS1iYXNlZCBuYW5vcGFydGljbGVzIGJ5IGRlc2lnbiBvZiBleHBlcmltZW50cy4gQUFQUyBQaGFybVNjaVRlY2guIDIwMTQ7IEZlYjsgMTUoMSk6IDE2MS03Ni4gZG9pOiAxMC4xMjA4L3MxMjI0OS0wMTMtMDA0OC05Ljxicj4xNi4mbmJzcDsmbmJzcDsmbmJzcDsgQWRuYW4gTS4gSmFzaW0sIEh1ZGEgRi4gSGFzYW4sIE1vaGFtbWVkIEouIEF3YWR5LiBQcmVwYXJhdGlvbiBvZiBWb3JhcGF4YXIgbG9hZGVkIHdpdGggVml0YW1pbiBFIFRQR1MgYW5kIFBWQSBlbXVsc2lmaWVkIFBMR0EgbmFub3BhcnRpY2xlcyBJbiB2aXRybyBzdHVkaWVzLiBSZXNlYXJjaCBKLiBQaGFybS4gYW5kIFRlY2guIDIwMTk7IDEyKDkpOiA0NTAzLTQ1MTAuIERPSTogMTAuNTk1OC8wOTc0LTM2MFguMjAxOS4wMDc3Ni41PGJyPjE3LiZuYnNwOyZuYnNwOyZuYnNwOyBIYWxldmFzIEUsIE1hdnJvaWRpIEIsIEtva290aWRvdSBDLCBNb3NjaG9uYSBBLCBTYWdub3UgTSwgTWl0cmFraSBBLCBMaXRzYXJkYWtpcyBHLCBQZWxlY2Fub3UgTS4gUmVtZGVzaXZpci1sb2FkZWQgYmlzLU1QQSBoeXBlcmJyYW5jaGVkIGRlbmRyaXRpYyBuYW5vY2FycmllcnMgZm9yIHB1bG1vbmFyeSBkZWxpdmVyeS4gSiBEcnVnIERlbGl2IFNjaSBUZWNobm9sLiAyMDIyOyBTZXA7IDc1OiAxMDM2MjUuIGRvaTogMTAuMTAxNi9qLmpkZHN0LjIwMjIuMTAzNjI1Ljxicj4xOC4mbmJzcDsmbmJzcDsmbmJzcDsgSGFsYXlxYSwgTW9oYW1tZWQgYW5kIERvbWHFhHNrYSwgVXJzenVsYS4gKDIwMTQpLiBQTEdBIEJpb2RlZ3JhZGFibGUgTmFub3BhcnRpY2xlcyBDb250YWluaW5nIFBlcnBoZW5hemluZSBvciBDaGxvcnByb21hemluZSBIeWRyb2NobG9yaWRlOiBFZmZlY3Qgb2YgRm9ybXVsYXRpb24gYW5kIFJlbGVhc2UuIEludGVybmF0aW9uYWwgSm91cm5hbCBvZiBNb2xlY3VsYXIgU2NpZW5jZXMuIDE1LiAyMzkwOS0yMy4gMTAuMzM5MC9pam1zMTUxMjIzOTA5LiBET0k6MTAuMTAwNy9zMTA4NzYtMDIyLTAyMjMyLTc8YnI+MTkuJm5ic3A7Jm5ic3A7Jm5ic3A7IE1hbmF5aSBBLCBCYWdoZXJpIE4sIERpbmFydmFuZCBSLCBFc2ZhbmR5YXJpLU1hbmVzaCBNLiBEZXNpZ24gYW5kIG9wdGltaXphdGlvbiBvZiBQTEdBLWJhc2VkIFRyaWJ1bHVzIHRlcnJlc3RyaXMgbG9hZGVkIG5hbm9wYXJ0aWNsZXMuIFJlc2VhcmNoIEpvdXJuYWwgb2YgUGhhcm1hY29nbm9zeS4gMjAyMjsgQXByIDE7IDkoMik6IDEtNy4gMTAuMjIxMjcvUkpQLjIwMjEuMzA1OTEzLjE3OTI8YnI+MjAuJm5ic3A7Jm5ic3A7Jm5ic3A7IEJBREFPVUksIEYuIFouIC4sIGFuZCBCb3V6aWQsIEQuICgyMDIyKS4gRm9ybXVsYXRpb24gYW5kIE9wdGltaXphdGlvbiBvZiBEaWNsb2ZlbmFjIFNvZGl1bSBMb2FkZWQgRXRoeWxjZWxsdWxvc2UgTmFub3BhcnRpY2xlcy4gQnJhemlsaWFuIEpvdXJuYWwgb2YgUGhhcm1hY2V1dGljYWwgU2NpZW5jZXMuIDU4LiBodHRwczovL2RvaS5vcmcvMTAuMTU5MC9zMjE3NS05NzkwMjAyMmUxOTU4PGJyPjIxLiZuYnNwOyZuYnNwOyZuYnNwOyBWaW5vZCBLdW1hcmksIEFkaXRpIFNhbmdhbC4gU3ludGhlc2lzLCBDaGFyYWN0ZXJpemF0aW9uLCBBbnRpbWljcm9iaWFsIGFjdGl2aXR5IGFuZCBSZWxlYXNlIFN0dWR5IG9mIENpbm5hbW9uIGxvYWRlZCBwb2x5IChETC1sYWN0aWRlLWNvLWdseWNvbGlkZSkgTmFub3BhcnRpY2xlcy4gUmVzZWFyY2ggSi4gUGhhcm0uIGFuZCBUZWNoLiAyMDE5OyAxMig0KTogMTUyOS0xNTM1LiBET0k6IDEwLjU5NTgvMDk3NC0zNjBYLjIwMTkuMDAyNTMuMTxicj4yMi4mbmJzcDsmbmJzcDsmbmJzcDsgTm96YWwgViwgUm9qYXMtUHJhdHMgRSwgTWFlc3RybyBJLCBHaWwgQywgUGVyZXogREksIE1hcnRpbmV6IEEuIEltcHJvdmVkIENvbnRyb2xsZWQgUmVsZWFzZSBhbmQgQnJhaW4gUGVuZXRyYXRpb24gb2YgdGhlIFNtYWxsIE1vbGVjdWxlIFMxNCBVc2luZyBQTEdBIE5hbm9wYXJ0aWNsZXMuIEludCBKIE1vbCBTY2kuIDIwMjE7IE1hciAyMjsgMjIoNik6IDMyMDYuIGRvaTogMTAuMzM5MC9pam1zMjIwNjMyMDYuPGJyPjIzLiZuYnNwOyZuYnNwOyZuYnNwOyBNaXJuZXphbWkgU01TLCBIZXlkYXJpbmFzYWIgQSwgQWtiYXJ6YWRlaGtoeWF2aSBBLCBBZHJqbWFuZCBNLiBEZXZlbG9wbWVudCBhbmQgT3B0aW1pemF0aW9uIG9mIExpcGlkLXBvbHltZXIgSHlicmlkIE5hbm9wYXJ0aWNsZXMgQ29udGFpbmluZyBNZWxwaGFsYW4gVXNpbmcgQ2VudHJhbCBDb21wb3NpdGUgRGVzaWduIGFuZCBJdHMgRWZmZWN0IG9uIE92YXJpYW4gQ2FuY2VyIENlbGwgTGluZXMuIElyYW4gSiBQaGFybSBSZXMuIDIwMjE7IEZhbGw7IDIwKDQpOiAyMTMtMjI4LiBkb2k6IDEwLjIyMDM3L2lqcHIuMjAyMS4xMTQ1NzUuMTQ5MjMuLjxicj4yNC4mbmJzcDsmbmJzcDsmbmJzcDsgUHJhamFwYXRpLCBCaHVwZW5kcmEgYW5kIFBhbGl3YWwsIEhpbWFuc2h1IGFuZCBQYXRlbCwgTWF5dXJlZS4gKDIwMjMpLiBGYWJyaWNhdGlvbiBhbmQgRXZhbHVhdGlvbiBvZiBQb2x5bWVyaWMgTmFub3BhcnRpY2xlcyBvZiBBY2l0cmV0aW4gZm9yIHRoZSBTb2x1YmlsaXR5IEVuaGFuY2VtZW50LiAxNi4gMjY1NS0yNjYwLi4gMTAuNTI3MTEvMDk3NC0zNjBYLjIwMjMuMDA0MzYuPGJyPjI1LiZuYnNwOyZuYnNwOyZuYnNwOyBaaG91IFlaLCBBbGFueSBSRywgQ2h1YW5nIFYsIFdlbiBKLiBPcHRpbWl6YXRpb24gb2YgUExHQSBuYW5vcGFydGljbGVzIGZvcm11bGF0aW9uIGNvbnRhaW5pbmcgTC1ET1BBIGJ5IGFwcGx5aW5nIHRoZSBjZW50cmFsIGNvbXBvc2l0ZSBkZXNpZ24uIERydWcgRGV2IEluZCBQaGFybS4gMjAxMzsgRmViOyAzOSgyKTogMzIxLTMwLiBkb2k6IDEwLjMxMDkvMDM2MzkwNDUuMjAxMi42ODEwNTQuPGJyPjI2LiZuYnNwOyZuYnNwOyZuYnNwOyBIYXNzYW4gSCwgQWRhbSBTSywgQWxpYXMgRSwgTWVvciBNb2hkIEFmZmFuZGkgTU1SLCBTaGFtc3VkZGluIEFGLCBCYXNpciBSLiBDZW50cmFsIENvbXBvc2l0ZSBEZXNpZ24gZm9yIEZvcm11bGF0aW9uIGFuZCBPcHRpbWl6YXRpb24gb2YgU29saWQgTGlwaWQgTmFub3BhcnRpY2xlcyB0byBFbmhhbmNlIE9yYWwgQmlvYXZhaWxhYmlsaXR5IG9mIEFjeWNsb3Zpci4gTW9sZWN1bGVzLiAyMDIxOyBTZXAgNzsgMjYoMTgpOiA1NDMyLiBkb2k6IDEwLjMzOTAvbW9sZWN1bGVzMjYxODU0MzIuPGJyPjI3LiZuYnNwOyZuYnNwOyZuYnNwOyBNYWhqb3ViIE1BLCBFYnJhaGltbmVqYWQgUCwgU2hhaGxhZWUgRiwgRWJyYWhpbWkgUCwgU2FkZWdoaS1HaGFkaSBaLiBQcmVwYXJhdGlvbiBhbmQgT3B0aW1pemF0aW9uIG9mIENvbnRyb2xsZWQgUmVsZWFzZSBOYW5vcGFydGljbGVzIENvbnRhaW5pbmcgQ2VmaXhpbWUgVXNpbmcgQ2VudHJhbCBDb21wb3NpdGUgRGVzaWduOiBBbiBBdHRlbXB0IHRvIEVucmljaCBJdHMgQW50aW1pY3JvYmlhbCBBY3Rpdml0eS4gQ3VyciBEcnVnIERlbGl2LiAyMDIyOyAxOSgzKTogMzY5LTM3OC4gZG9pOiAxMC4yMTc0LzE1NjcyMDE4MTg2NjYyMTA3MjYxNjA5NTYuPGJyPjI4LiZuYnNwOyZuYnNwOyZuYnNwOyBCaGFyZ2F2IEUsIFJlZGR5IENTLCBTb3dteWEgQywgSGFyYW5hdGggQywgS2hhbiBLQSwgUmFqZXNoIEssIFNyaW5hdGggQi4gRm9ybXVsYXRpb24gYW5kIG9wdGltaXphdGlvbiBvZiBwaXJveGljYW0gb3JvZGlzcGVyc2libGUgdGFibGV0cyBieSBjZW50cmFsIGNvbXBvc2l0ZSBkZXNpZ24uIEpvdXJuYWwgb2YgWW91bmcgUGhhcm1hY2lzdHMuIDIwMTc7IDkoMik6IDE4Ny4gRE9JOjEwLjU1MzAvanlwLjIwMTcuOS4zNzxicj4yOS4mbmJzcDsmbmJzcDsmbmJzcDsgUnVrbWFuZ2F0aGVuIFIsIFlhbGxhbWFsbGkgSU0sIFlhbGF2YXJ0aGkgUFIuIEZvcm11bGF0aW9uIGFuZCBiaW9waGFybWFjZXV0aWNhbCBldmFsdWF0aW9uIG9mIHJpc3Blcmlkb25lLWxvYWRlZCBjaGl0b3NhbiBuYW5vcGFydGljbGVzIGZvciBpbnRyYW5hc2FsIGRlbGl2ZXJ5LiBEcnVnIERldiBJbmQgUGhhcm0uIDIwMTk7IEF1ZzsgNDUoOCk6IDEzNDItMTM1MC4gZG9pOiAxMC4xMDgwLzAzNjM5MDQ1LjIwMTkuMTYxOTc1OS48YnI+MzAuJm5ic3A7Jm5ic3A7Jm5ic3A7IFlhZGF2IEtTLCBTYXdhbnQgS0suIE1vZGlmaWVkIG5hbm9wcmVjaXBpdGF0aW9uIG1ldGhvZCBmb3IgcHJlcGFyYXRpb24gb2YgY3l0YXJhYmluZS1sb2FkZWQgUExHQSBuYW5vcGFydGljbGVzLiBBQVBTIFBoYXJtU2NpVGVjaC4gMjAxMDsgU2VwOyAxMSgzKTogMTQ1Ni02NS4gZG9pOiAxMC4xMjA4L3MxMjI0OS0wMTAtOTUxOS00PGJyPjMxLiZuYnNwOyZuYnNwOyZuYnNwOyBTaGkgVywgWmhhbmcgWkosIFl1YW4gWSwgWGluZyBFTSwgUWluIFksIFBlbmcgWkosIFpoYW5nIFpQLCBZYW5nIEtZLiBPcHRpbWl6YXRpb24gb2YgcGFyYW1ldGVycyBmb3IgcHJlcGFyYXRpb24gb2YgZG9jZXRheGVsLWxvYWRlZCBQTEdBIG5hbm9wYXJ0aWNsZXMgYnkgbmFub3ByZWNpcGl0YXRpb24gbWV0aG9kLiBKIEh1YXpob25nIFVuaXYgU2NpIFRlY2hub2xvZyBNZWQgU2NpLiAyMDEzOyBPY3Q7IDMzKDUpOiA3NTQtNzU4LiBkb2k6IDEwLjEwMDcvczExNTk2LTAxMy0xMTkyLXguPGJyPjMyLiZuYnNwOyZuYnNwOyZuYnNwOyBILiBVbWFtYWhlc3ZhcmkuIEZhYnJpY2F0aW9uIGFuZCBDaGFyYWN0ZXIgU3R1ZHkgb2YgdGhlIEFudGljYW5jZXIgRHJ1ZyBQYWNsaXRheGVsIChUYXhvbCk6IFBMR0EgbmFub3BhcnRpY2xlcyAtIFRoZSBiZW5lZmFjdGlvbiBmb3IgdGhlIG1vZGVybiB0aGVyYXBldXRpYyBhcmVhLiBSZXNlYXJjaCBKLiBQaGFybS4gYW5kIFRlY2guIDIwMjA7IDEzKDEpOiAyNjUtMjY5LiBET0k6IDEwLjU5NTgvMDk3NC0zNjBYLjIwMjAuMDAwNTQuMjxicj4zMy4mbmJzcDsmbmJzcDsmbmJzcDsgTW9yYWxlcy1DcnV6IE0sIEZsb3Jlcy1GZXJuw6FuZGV6IEdNLCBNb3JhbGVzLUNydXogTSwgT3JlbGxhbm8gRUEsIFJvZHJpZ3Vlei1NYXJ0aW5leiBKQSwgUnVpeiBNLCBHcmllYmVub3cgSy4gVHdvLXN0ZXAgbmFub3ByZWNpcGl0YXRpb24gZm9yIHRoZSBwcm9kdWN0aW9uIG9mIHByb3RlaW4tbG9hZGVkIFBMR0EgbmFub3NwaGVyZXMuIFJlc3VsdHMgUGhhcm1hIFNjaS4gMjAxMjsgMjogNzktODUuIGRvaTogMTAuMTAxNi9qLnJpbnBocy4yMDEyLjExLjAwMS48YnI+MzQuJm5ic3A7Jm5ic3A7Jm5ic3A7IFNpdmFwcmFzYWQgUywgU2FkYWt2YWxpIEMsIEt1bWFyIFZSLCBLcmlzaG5hIFBNLCBZdXN1ZiBTTSwgU3Jpa2FudGggQS4gRm9ybXVsYXRpb24gYW5kIENoYXJhY3Rlcml6YXRpb24gb2YgVGVub2ZvdmlyIERpc3Byb3h5bCBGdW1lcmF0ZSBOYW5vcGFydGljbGVzIHByZXBhcmVkIGJ5IE5hbm9wcmVjaXBpdGF0aW9uIE1ldGhvZC4gUmVzZWFyY2ggSm91cm5hbCBvZiBQaGFybWFjeSBhbmQgVGVjaG5vbG9neS4gMjAyMjsgSnVsIDI5OyAxNSg3KTogMzA3NS04MC4xMC41MjcxMS8wOTc0LTM2MFguMjAyMi4wMDUxNCAmbmJzcDs8YnI+MzUuJm5ic3A7Jm5ic3A7Jm5ic3A7IE1hcmluZWxsaSBMLCBDaXVsbGEgTSwgUml0c2VtYSBKQVMsIHZhbiBOb3N0cnVtIENGLCBDYWNjaWF0b3JlIEksIERpbW1pdG8gTVAsIFBhbG1lcmlvIEYsIE9ybGFuZG8gRywgUm9idWZmbyBJLCBHcmFuZGUgUiwgUHVjYSBWLCBEaSBTdGVmYW5vIEEuIFByZXBhcmF0aW9uLCBDaGFyYWN0ZXJpemF0aW9uLCBhbmQgQmlvbG9naWNhbCBFdmFsdWF0aW9uIG9mIGEgSHlkcm9waGlsaWMgUGVwdGlkZSBMb2FkZWQgb24gUEVHLVBMR0EgTmFub3BhcnRpY2xlcy4gUGhhcm1hY2V1dGljcy4gMjAyMjsgQXVnIDI5OyAxNCg5KTogMTgyMS4gZG9pOiAxMC4zMzkwL3BoYXJtYWNldXRpY3MxNDA5MTgyMS48YnI+MzYuJm5ic3A7Jm5ic3A7Jm5ic3A7IFRyaXBhdGhpIFNLLCBQYXRlbCBCLCBTaHVrbGEgUywgUGFjaG91cmkgQywgUGF0aGFrIFMsIFBhbmRleSBBLiBEb25lcGV6aWwgbG9hZGVkIFBMR0EgbmFub3BhcnRpY2xlcywgZnJvbSBtb2RpZmllZCBuYW5vLXByZWNpcGl0YXRpb24sIGFuIGFkdmFuY2VkIGRydWcgZGVsaXZlcnkgc3lzdGVtIHRvIHRyZWF0IGFsemhlaW1lciBkaXNlYXNlLiBKIFBoeXM6IENvbmYgU2VyLiAyMDIxOyAxODQ5KDEpOiAwMTIwMDEuIGRvaTogMTAuMTA4OC8xNzQyLTY1OTYvMTg0OS8xLzAxMjAwMS48YnI+MzcuJm5ic3A7Jm5ic3A7Jm5ic3A7IElyZmFuIE0uIFNhaXl5YWQsIEQuIFMuIEJoYW1iZXJlLCBTYW5qYXkgS3NoaXJzYWdhci4gRm9ybXVsYXRpb24gYW5kIE9wdGltaXphdGlvbiBvZiBTaWx5bWFyaW4gTG9hZGVkIFBMR0EgTmFub3BhcnRpY2xlIGZvciBsaXZlciB0YXJnZXRpbmcuIEFzaWFuIEouIFBoYXJtLiBUZWNoLiAyMDE3OyA3ICg0KTogMjA5LTIyMCAuIERPSTogMTAuNTk1OC8yMjMxLTU3MTMuMjAxNy4wMDAzMi4wPGJyPjM4LiZuYnNwOyZuYnNwOyZuYnNwOyBKYWluZXkgUC4gSmFtZXMsIFNuZWggUHJpeWEsIERpdnlhIEp5b3RoaS4gRWZmZWN0IG9mIFBMR0EgcG9seW1lciBvbiBBbnRpbWljcm9iaWFsIEFjdGl2aXR5IGFuZCB0aGUgUmVsZWFzZSBTdHVkaWVzIG9mIE5hbm9wYXJ0aWNsZSBIeWRyb2dlbCBDb250YWluaW5nIE1pbW9zYSBwdWRpY2EgRXh0cmFjdC4gUmVzZWFyY2ggSi4gUGhhcm0uIGFuZCBUZWNoLiAyMDE4OyAxMSg3KTogMjg3Ni0yODgwLiBET0k6IDEwLjU5NTgvMDk3NC0zNjBYLjIwMTguMDA1MzAuOTxicj4zOS4mbmJzcDsmbmJzcDsmbmJzcDsgUiwgVi4gSy4sIGFuZCBCLiwgSi4gSi4gQ2VudHJhbCBjb21wb3NpdGUgZmFjZS1jZW50ZXJlZCBkZXNpZ24tYmFzZWQgb3B0aW1pc2F0aW9uLCBkZXZlbG9wbWVudCBhbmQgY2hhcmFjdGVyaXNhdGlvbiBvZiBmYXZpcGlyYXZpci1sb2FkZWQgcGxnYSBuYW5vcGFydGljbGVzLiBJbnRlcm5hdGlvbmFsIEpvdXJuYWwgb2YgQXBwbGllZCBQaGFybWFjZXV0aWNzLiAyMDIzOyAxNSgxKTogMjM04oCTMjQ5LiBodHRwczovL2RvaS5vcmcvMTAuMjIxNTkvaWphcC4yMDIzdjE1aTEuNDYyODk8YnI+NDAuJm5ic3A7Jm5ic3A7Jm5ic3A7IEthbGlkYXMgUywgR2VldGhhIFAuIERldmVsb3BtZW50IGFuZCBvcHRpbWl6YXRpb24gb2YgYXN0cmFnYWxpbi1sb2FkZWQgcG9seW1lcmljIG5hbm9wYXJ0aWNsZXMgdXNpbmcgY2VudHJhbCBjb21wb3NpdGUgZmFjdG9yaWFsIGRlc2lnbi4gSW50IEogQXBwIFBoYXJtLiAyMDIyOyAxNCg1KTogNjktNzcuIGRvaTogMTAuMjIxNTkvaWphcC4yMDIydjE0aTUuNDQzMTUuPGJyPjQxLiZuYnNwOyZuYnNwOyZuYnNwOyBJLiBTb21hc3VuZGFyYW0sIEIuVi4gTmFnYXJqdW5hIFlhZGF2LCBTLiBTYXRoZXNoIEt1bWFyLiBGb3JtdWxhdGlvbiBvZiBQTEdBIFBvbHltZXJpYyBOYW5vc3VzcGVuc2lvbiBjb250YWluaW5nIFByYW1pcGV4b2xlIERpaHlkcm9jaGxvcmlkZSBmb3IgaW1wcm92ZWQgdHJlYXRtZW50IG9mIFBhcmtpbnNvbuKAmXMgRGlzZWFzZXMuIFJlc2VhcmNoIEouIFBoYXJtLiBhbmQgVGVjaC4gMjAxNjsgOSg3KTogODEwLTgxNiAuIERPSTogMTAuNTk1OC8wOTc0LTM2MFguMjAxNi4wMDE1NS40PGJyPjQyLiZuYnNwOyZuYnNwOyZuYnNwOyBBZGl0eWEgTi4gUGFuZGV5LCBSYWtlc2ggUmFqLCBOIEdhbmVzaCwgU3VuaWwgSy4gSmFpbi4gQ29uY2FuYXZhbGluLUEgQ29uanVnYXRlZCA1LUZsdW9yb3VyYWNpbCBMb2FkZWQgUExHQSBOYW5vcGFydGljbGVzOiBBIE5vdmVsIEFwcHJvYWNoIGZvciBFZmZlY3RpdmUgVHJlYXRtZW50IG9mIENvbG9yZWN0YWwgQ2FuY2VyLiBSZXNlYXJjaCBKLiBQaGFybS4gYW5kIFRlY2guIDIwMTg7IDExKDcpOiAyNzgyLTI3OTEgRE9JOiAxMC41OTU4LzA5NzQtMzYwWC4yMDE4LjAwNTE0LjA8YnI+NDMuJm5ic3A7Jm5ic3A7Jm5ic3A7IEplc3N5IFNoYWppLCBNb25pa2EgS3VtYmhhci4gTGluZXpvbGlkIExvYWRlZCBCaW9kZWdyYWRhYmxlIFBvbHltZXJpYyBOYW5vcGFydGljbGVzIEZvcm11bGF0aW9uIGFuZCBDaGFyYWN0ZXJpemF0aW9uLiBSZXMuIEouIFBoYXJtLiBEb3NhZ2UgRm9ybS4gYW5kIFRlY2guIDIwMTg7IDEwKDQpOiAyNzItMjc4LiBET0k6IDEwLjU5NTgvMDk3NS00Mzc3LjIwMTguMDAwNDAuWDxicj40NC4mbmJzcDsmbmJzcDsmbmJzcDsgR29oaWwgRCwgU2hhaCBOLCBNYWhlc2h3YXJpIFJBLiBFZmZlY3Qgb2YgRm9ybXVsYXRpb24gVmFyaWFibGVzIG9uIEZhYnJpY2F0aW9uIG9mIFJpc3Blcmlkb25lIExvYWRlZCBOYW5vcGFydGljbGVzIGZvciBTdXN0YWluZWQgRHJ1ZyBEZWxpdmVyeS4gSW5kaWFuIGpvdXJuYWwgb2YgcGhhcm1hY2V1dGljYWwgZWR1Y2F0aW9uIGFuZCByZXNlYXJjaC4gMjAyMiBqYW4gMTs1NigxKTo1OC02NC4gRG9pOjEwNTUzMC9pampwZXIuNTYuMS44PGJyPjQ1LiZuYnNwOyZuYnNwOyZuYnNwOyBTYWhpbiBBLCBFc2VuZGFnbGkgRywgWWVybGlrYXlhIEYsIENhYmFuVG9rdGFzIFMsIFlveWVuRXJtaXMgRCwgSG9yenVtIFUuIEEgc21hbGwgdmFyaWF0aW9uIGluIGF2ZXJhZ2UgcGFydGljbGUgc2l6ZSBvZiBQTEdBIG5hbm9wYXJ0aWNsZXMgcHJlcGFyZWQgYnkgbmFub3ByZWNpcGl0YXRpb24gbGVhZHMgdG8gY29uc2lkZXJhYmxlIGNoYW5nZSBpbiBuYW5vcGFydGljbGVz4oCZIGNoYXJhY3RlcmlzdGljcyBhbmQgZWZmaWNhY3kgb2YgaW50cmFjZWxsdWxhciBkZWxpdmVyeS4gQXJ0aWYgQ2VsbHMgTmFub21lZEJpb3RlY2hub2wuIDIwMTc7NDUoOCk6MTY1Ny02NC4gZG9pOiAxMC4xMDgwLyAyMTY5MTQwMS4yMDE2LjEyNzY5MjQsLjxicj40Ni4mbmJzcDsmbmJzcDsmbmJzcDsgUmFvIFNWLCBLdW1hciBTUy4gRmx1dGFtaWRlIGxvYWRlZCBwb2x5bWVyaWMgbmFub3BhcnRpY2xlcyBmb3IgcHJvc3RhdGUgY2FuY2VyOiBBIHJldmlldy4gUmVzZWFyY2ggSm91cm5hbCBvZiBQaGFybWFjeSBhbmQgVGVjaG5vbG9neS4gMjAyMTsxNCg4KTo0NTAxLTMuaHR0cHM6Ly9kb2kub3JnLzEwLjUyNzExLzA5NzQtMzYwWC4yMDIxLjAwNzgyPGJyPjxicj48YnI+ZGQCJw88KwAJAGQCBg8PFgIfAgUYQ0hIRU5HMDAzODcvMzMvMS8yMDA4LVRDZGQCBw8PFgIfAgURMTAuNTk1OC8wOTc0LTM2MFhkZAIJDzwrAAkBAA8WBB4IRGF0YUtleXMWAB4LXyFJdGVtQ291bnQCCGQWEGYPZBYCZg8VBAIxOAExDEphbnVhcnkgMjAyNQI2OGQCAQ9kFgJmDxUEAjE3AjEyDURlY2VtYmVyIDIwMjQCNzJkAgIPZBYCZg8VBAIxNwIxMQ1Ob3ZlbWJlciAyMDI0AjcxZAIDD2QWAmYPFQQCMTcCMTAMT2N0b2JlciAyMDI0Ajc3ZAIED2QWAmYPFQQCMTcBOQ5TZXB0ZW1iZXIgMjAyNAI3NmQCBQ9kFgJmDxUEAjE3ATgLQXVndXN0IDIwMjQCODdkAgYPZBYCZg8VBAIxNwE3CUp1bHkgMjAyNAI4NWQCBw9kFgJmDxUEAjE3ATYJSnVuZSAyMDI0Ajg2ZAIKDzwrAAkBAA8WBB8EFgAfBQIPZBYeZg9kFgJmDxUEDDIwMjAtMTMtNy03NAwyMDIwLTEzLTctNzQMMjAyMC0xMy03LTc0blBoYXJtYWNldXRpY2FsIEluY29tcGF0aWJpbGl0aWVzOiBDYXVzZXMsIFR5cGVzIGFuZCBNYWpvciB3YXlzIG9mIE92ZXJjb21pbmcgaW4gRXh0ZW1wb3JhbmVvdXMgTWVkaWNpbmFsIGZvcm1zZAIBD2QWAmYPFQQMMjAxNi05LTExLTExDDIwMTYtOS0xMS0xMQwyMDE2LTktMTEtMTFFU2V4IGRldGVybWluYXRpb24gdXNpbmcgdGhlIG1hc3RvaWQgcHJvY2VzcyB1c2luZyBTb3V0aCBJbmRpYW4gc2t1bGxzZAICD2QWAmYPFQQMMjAyMC0xMy0xLTQzDDIwMjAtMTMtMS00MwwyMDIwLTEzLTEtNDMvRm9ybXVsYXRpb24gYW5kIEV2YWx1YXRpb24gb2YgSGVyYmFsIEZhY2UgQ3JlYW1kAgMPZBYCZg8VBAwyMDE3LTEwLTktNDIMMjAxNy0xMC05LTQyDDIwMTctMTAtOS00MmhEZXRlY3Rpb24gb2YgRm9vZCBBZHVsdGVyYW50cyBpbiBDaGlsbGksIFR1cm1lcmljIGFuZCBDb3JpYW5kZXIgUG93ZGVycyBieSBQaHlzaWNhbCBhbmQgQ2hlbWljYWwgTWV0aG9kc2QCBA9kFgJmDxUEDDIwMjAtMTMtNC0xNgwyMDIwLTEzLTQtMTYMMjAyMC0xMy00LTE2LkZvcm11bGF0aW9uIGFuZCBFdmFsdWF0aW9uIG9mIEhlcmJhbCBMaXBzdGlja3NkAgUPZBYCZg8VBAwyMDE3LTEwLTktMTkMMjAxNy0xMC05LTE5DDIwMTctMTAtOS0xOYcBRm9ybXVsYXRpb24gYW5kIEV2YWx1YXRpb24gb2YgQXNwaXJpbiBUYWJsZXRzIGJ5IFVzaW5nIERpZmZlcmVudCBMdWJyaWNhbnRzIGluIENvbWJpbmF0aW9uIGZvciBiZXR0ZXIgS2luZXRpYyBEcnVnIFJlbGVhc2UgU3R1ZHkgYnkgUENQZAIGD2QWAmYPFQQMMjAyMC0xMy0zLTgxDDIwMjAtMTMtMy04MQwyMDIwLTEzLTMtODE/UmVndWxhdG9yeSByZXF1aXJlbWVudHMgZm9yIGNvbmR1Y3RpbmcgQ2xpbmljYWwgVHJpYWxzIGluIEluZGlhZAIHD2QWAmYPFQQNMjAxOS0xMi0xMS04MA0yMDE5LTEyLTExLTgwDTIwMTktMTItMTEtODAXRGVudGFsIFdheGVz4oCTQSBSZXZpZXdkAggPZBYCZg8VBAsyMDEzLTYtMi0xNQsyMDEzLTYtMi0xNQsyMDEzLTYtMi0xNSdNZWRpY2luYWwgUGxhbnRzIGZyb20gU29sYW5hY2VhZSBGYW1pbHlkAgkPZBYCZg8VBAsyMDE0LTctOS0xNAsyMDE0LTctOS0xNAsyMDE0LTctOS0xNB5UaGUgVXNlIG9mIE5lZW0gaW4gT3JhbCBIZWFsdGhkAgoPZBYCZg8VBAwyMDE5LTEyLTEtNjkMMjAxOS0xMi0xLTY5DDIwMTktMTItMS02OTVSZWNlbnQgQWR2YW5jZXMgaW4gUHJldmVudGl2ZSBSZXNpbiBSZXN0b3JhdGlvbiAoUFJSKWQCCw9kFgJmDxUECjIwMTEtNC05LTIKMjAxMS00LTktMgoyMDExLTQtOS0yLEZvcm11bGF0aW9uIGFuZCBFdmFsdWF0aW9uI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</div> </div> <div class="col-md-2 col-lg-2 col-sm-12 col-xs-12"> <div class="opening_time s_header"> <p class="uppercase" style="color: #1a00cc; font-size: 14px; font-weight: bold">ISSN</p> <p style="color: #1a00cc; line-height: 21px"> 0974-360X (Online) <br /> 0974-3618 (Print) </p> </div> </div> </div> </div> <br /> </div> </div>   <section class="slider_area"> <div class="mainmenu_area"> <div class="container"> <div class="row"> <div class="col-md-10 col-lg-10"> <div class="mainmenu nav"> <nav> <ul id="nav"> <li class="current"><a href="Home.aspx">Home <i class="fa fa-angle-down"></i></a> <ul> <li><a href="AboutJournal.aspx">About Journal</a></li> <li><a href="Indexed_In.aspx">Indexing Information</a></li> <li><a href="ContactUs.aspx">Raise Query</a></li> </ul> </li> <li><a href="PastIssues.aspx">Past Issues</a></li> <li><a href="EditorialBoard.aspx">Editorial Board</a></li> <li><a href="#">For Authors <i class="fa fa-angle-down"></i></a> <ul> <li><a 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class="request_code"> <a href="SubmitArticle.aspx">Submit Article</a> </div> </div> </div> </div> </div> </section>  <div class="container"> <div class="col-md-9 col-lg-9 col-sm-12 col-xs-12"> <section class="blog_area section_padding"> <div class="row"> <div class="Abstract_page_title text-center"> <h1> <span id="ContentPlaceHolder1_PaperTitle" style="font-weight:bold;"><a href='AbstractView.aspx?PID=2025-18-1-41' class='myLink'>Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software</a><a href='https://scholar.google.co.in/scholar?q=Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software' target='_blank' style='color:blue'> <img src='Images/GoogleScholar.png' style='height:23px'></a></span> </h1> </div> <div class="single_blog"> <div style="background: #f6f6f6 none repeat scroll 0 0; padding: 8px; border-left: 4px solid #11c3f1"> <p style="text-align: left; font-size: 14px"> <span style="color: rgba(193, 4, 4, 0.76)">Author(s):</span> <span id="ContentPlaceHolder1_AuthorName"><a href='search.aspx?key=Rishika Chauhan' >Rishika Chauhan</a>, <a href='search.aspx?key=Anuj Malik' >Anuj Malik</a></span> </p> <p style="text-align: left; font-size: 14px"> <span style="color: rgba(193, 4, 4, 0.76)">Email(s):</span> <span id="ContentPlaceHolder1_AuthorEmail"><a href='mailto:rishichauhan789@gmail.com' target='_blank' >rishichauhan789@gmail.com</a> , <a href='mailto:anujmalik007@gmail.com' target='_blank' >anujmalik007@gmail.com</a> </span> </p> <p style="text-align: left; font-size: 14px;"> <span style="color: rgba(193, 4, 4, 0.76)">DOI:</span> <span id="ContentPlaceHolder1_DOI_No" style="font-weight:normal;"><a href='https://doi.org/10.52711/0974-360X.2025.00041' target='_blank' style='color:blue'>10.52711/0974-360X.2025.00041</a>    <a href='https://scholar.google.co.in/scholar?q=10.52711/0974-360X.2025.00041' target='_blank' style='color:blue'> <img src='Images/GoogleScholar.png' style='height:25px'></a></span> </p> <p style="text-align: left; font-size: 14px"> <span style="color: rgba(193, 4, 4, 0.76)">Address:</span> <span id="ContentPlaceHolder1_AuthorAddress">Rishika Chauhan, Anuj Malik*<br> Department of Pharmaceutics, M M College of Pharmacy, Maharshi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India 133207.<br> *Corresponding Author</span> </p> <p style="text-align: left; font-size: 13px; margin-top: 5px"> <span style="color: rgba(193, 4, 4, 0.76)">Published In:</span>   <a href="Issues.aspx?VID=18&IID=1" id="ContentPlaceHolder1_Vol_Issue_link" style="font-weight:bold">Volume - <span id="ContentPlaceHolder1_VOL_no" style="font-weight:normal;">18</span>,      Issue - <span id="ContentPlaceHolder1_ISSUE_no" style="font-weight:normal;">1</span>,     Year - <span id="ContentPlaceHolder1_Pub_Year" style="font-weight:normal;">2025</span> </a> </p> <div class="clearfix"></div> <div style="float:right;"> <span id="ContentPlaceHolder1_Cite_icon_lbl" style="font-weight:normal;"><script async src='https://badge.dimensions.ai/badge.js' charset='utf-8'></script> <span class='__dimensions_badge_embed__' data-doi='10.52711/0974-360X.2025.00041' data-style='small_circle'></span> <div class='clearfix'></div></span> </div> <div class="blog_page" style="padding: 10px; margin-bottom: 28px"> <a href="HTMLPaper.aspx?Journal=Research Journal of Pharmacy and Technology;PID=2025-18-1-41" id="ContentPlaceHolder1_HTML_View_lnk" class="top_quate_action2 float_Right"> <img src="Images/html.png" />  View HTML</a>      <a id="ContentPlaceHolder1_Subscribe_btn" class="top_quate_action2 float_Right" href="javascript:__doPostBack('ctl00$ContentPlaceHolder1$Subscribe_btn','')"><img src="Images/cart_add.png" style="height:28px" />   Purchase PDF</a> </div> <div class="clearfix"></div> </div> <div class="blog_content blog_page"> <br /> <p style="text-align: justify"> <span style="color: black; font-weight: bold">ABSTRACT:</span> <br /> <span id="ContentPlaceHolder1_Abstract" style="color:Black;">Aloin is an anthraquinone glycoside with high-volume applications in food and pharmaceutical products. In this work use of polyvinyl alcohol was first used, as per previous work mentioned inthe literature to dissolve the aloin molecule while entrapping it poly (D, L-lactide-co-glycolide) PLGA, the study investigates the aloin nanoparticles by using an important tool of drug design software stat expert 13 version. The nanoprecipitation process is used for Aloin nanoparticle formulation by involving PLGA polymer and optimizing the formulation by central composite (CC) design of response surface. The experiment was designed using four criteria, as described in the article, and two factors were investigated to improve the size of particles and (EE) entangled efficiency of drug aloin. The optimal formulation of the drug was characterized by various parameters involving Scanning, transmission Microscopy i.e. (SEM-TEM), and in vitro release parameters. With a zero-order release parameter, the formulation had an EE of drug 98.06% and a drug particle size of 98.5nm. The result of aloin nanoformulation with the help of statistical experimental design demonstrates that the optimized aloin formulation of nanoparticles improves the bioavailability and the process variables to achieve a favorable result.</span> </p> <br /> <div class="tags"> <i class="text-left" style="color:black; font-size: 13px; font-weight: normal">Keywords:</i> <span id="ContentPlaceHolder1_Key_words" style="font-size:Smaller;"><ul class='text-left'><li><a href=''Central composite design statistical design' target='_blank' >Central composite design statistical design</a></li><li><a href=''Aloin' target='_blank' >Aloin</a></li><li><a href=''Controlled release' target='_blank' >Controlled release</a></li><li><a href=''PLGA' target='_blank' >PLGA</a></li><li><a href=''Nanoprecipitation method' target='_blank' >Nanoprecipitation method</a></li><li><a href=''SEM.' target='_blank' >SEM.</a></li></ul></span> </div> </div> <div class="highlight_text"> <img src="img/hilight.png" alt=""> <p> <span style="color: rgba(193, 4, 4, 0.76)">Cite this article:</span> <br /> <span id="ContentPlaceHolder1_Cite">Rishika Chauhan, Anuj Malik. Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software. Research Journal of Pharmacy and Technology. 2025;18(1):266-2. doi: 10.52711/0974-360X.2025.00041</span> <br /><br /> <span style="color: rgba(193, 4, 4, 0.76)">Cite(Electronic):</span> <br> <span id="ContentPlaceHolder1_Cite1">Rishika Chauhan, Anuj Malik. Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software. Research Journal of Pharmacy and Technology. 2025;18(1):266-2. doi: 10.52711/0974-360X.2025.00041   Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-41</span> </p> </div> <div class="clearfix"></div> <br /> <span id="ContentPlaceHolder1_Additional_Information_lbl"><b>8. REFERENCE: </b><br>1.    Venkatesh DN, Baskaran M, Karri VV, Mannemala SS, Radhakrishna K, Goti S. Fabrication and in vivo evaluation of nelfinavir loaded PLGA nanoparticles for enhancing oral bioavailability and therapeutic effect. Saudi Pharm J. 2015; 23(6): 667-74. doi: 10.1016/j.jsps.2015.02.021.<br>2.    Mainardes RM, Evangelista RC. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. Int J Pharm. 2005; 290(1-2): 137-44. doi: 10.1016/j.ijpharm.2004.11.027.<br>3.    Mohanraj VJ, Chen Y. Nanoparticles-a review. Tropical Journal of Pharmaceutical Research. 2006; 5(1): 561-73. DOI:10.4314/tjpr.v5i1.14634<br>4.    Kadian, R. “nanoparticles: a promising drug delivery approach”. Asian Journal of Pharmaceutical and Clinical Research. 2018; Jan. 11(1): 30-35, doi:10.22159/ajpcr.2018.v11i1.22035.<br>5.    Candioti LV, De Zan MM, Cámara MS, Goicoechea HC. Experimental design and multiple response optimization. Using the desirability function in analytical methods development. Talanta. 2014; Jun 15; 124: 123-38.https://doi.org/10.1016/j.talanta.2014.01.034<br>6.    Esmat AY, Tomasetto C, Rio M C. Cytotoxicity of a natural anthraquinone (aloin) against human breast cancer cell lines with and without ErbB 2-topoisomerase IIα amplification. Cancer Biol Ther. 2006; 5: 97–103 DOI: 10.4161/cbt.5.1.2347<br>7.    Eli Harlev, Eviatar Nevo, Ephraim P. Lansky1, Rivka Ofir2, Anupam Bishayee. Anticancer Potential of Aloes: Antioxidant, Antiproliferative, and Immunostimulatory Attributes Planta Med 2012; 78: 843–852 DOI: 10.1055/s-0031-1298453<br>8.    Park, M.Y., Kwon, H.J. and Sung, M.K. 2008b. Plasma, tissue, and urinary levels of aloin in rats after the administration of pure aloin. Nutrition Research and Practice. 2: 17-21. doi: 10.4162/nrp.2008.2.1.17<br>9.    Park MY, Kwon HJ, Sung MK. Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. Nutr Res Pract. 2008; Spring; 2(1): 17-21. doi: 10.4162/nrp.2008.2.1.17.<br>10.    Ma Y, Tang T, Sheng L, Wang Z, Tao H, Zhang Q, Zhang Y, Qi Z. Aloin suppresses lipopolysaccharide induced inflammation by inhibiting JAK1 STAT1/3 activation and ROS Production in RAW264.7 cells. Int J Mol Med. 2018; Oct; 42(4): 1925-1934. doi: 10.3892/ijmm.2018.3796. Epub 2018 Jul 31.<br>11.    S. Sivaprasad, Ch. Sadakvali, V. Ravi Kumar, P.V. Murali Krishna, Shaik Mohammed Yusuf , A. Srikanth. Formulation and Characterization of Tenofovir Disproxyl Fumerate Nanoparticles prepared by Nanoprecipitation Method. Research Journal of Pharmacy and Technology. 2022; 15(7): 3075-0 DOI: 10.52711/0974-360X.2022.00514.<br>12.    Badaoui FZ, Bouzid D. Formulation and Optimization of Diclofenac Sodium Loaded Ethylcellulose Nanoparticles. Brazilian Journal of Pharmaceutical Sciences. 2022; Jun 24; 58. https://doi.org/10.1590/s2175-97902022e19586<br>13.    Ciocilteu MV, Nicolaescu OE, Mocanu AG, Nicolicescu C, Rau G, Neamtu J, Amzoiu E, Amzoiu E, Oancea C, Turcu-Stiolica a. Process optimization using quality by design (qbd) approach of a gentamicin loaded plga biocomposite. Journal of Science and Arts. 2021; Oct 1; 21(4): 1069-80. DOI:10.46939/J.Sci.Arts-21.4-b02<br>14.    Cooper DL, Harirforoosh S. Design and optimization of PLGA-based diclofenac loaded nanoparticles. PLoS One. 2014; Jan 28; 9(1): e87326. doi: 10.1371/journal.pone.0087326.<br>15.    Turk CT, Oz UC, Serim TM, Hascicek C. Formulation and optimization of nonionic surfactants emulsified nimesulide-loaded PLGA-based nanoparticles by design of experiments. AAPS PharmSciTech. 2014; Feb; 15(1): 161-76. doi: 10.1208/s12249-013-0048-9.<br>16.    Adnan M. Jasim, Huda F. Hasan, Mohammed J. Awady. Preparation of Vorapaxar loaded with Vitamin E TPGS and PVA emulsified PLGA nanoparticles In vitro studies. Research J. Pharm. and Tech. 2019; 12(9): 4503-4510. DOI: 10.5958/0974-360X.2019.00776.5<br>17.    Halevas E, Mavroidi B, Kokotidou C, Moschona A, Sagnou M, Mitraki A, Litsardakis G, Pelecanou M. Remdesivir-loaded bis-MPA hyperbranched dendritic nanocarriers for pulmonary delivery. J Drug Deliv Sci Technol. 2022; Sep; 75: 103625. doi: 10.1016/j.jddst.2022.103625.<br>18.    Halayqa, Mohammed and Domańska, Urszula. (2014). PLGA Biodegradable Nanoparticles Containing Perphenazine or Chlorpromazine Hydrochloride: Effect of Formulation and Release. International Journal of Molecular Sciences. 15. 23909-23. 10.3390/ijms151223909. DOI:10.1007/s10876-022-02232-7<br>19.    Manayi A, Bagheri N, Dinarvand R, Esfandyari-Manesh M. Design and optimization of PLGA-based Tribulus terrestris loaded nanoparticles. Research Journal of Pharmacognosy. 2022; Apr 1; 9(2): 1-7. 10.22127/RJP.2021.305913.1792<br>20.    BADAOUI, F. Z. ., and Bouzid, D. (2022). Formulation and Optimization of Diclofenac Sodium Loaded Ethylcellulose Nanoparticles. Brazilian Journal of Pharmaceutical Sciences. 58. https://doi.org/10.1590/s2175-97902022e1958<br>21.    Vinod Kumari, Aditi Sangal. Synthesis, Characterization, Antimicrobial activity and Release Study of Cinnamon loaded poly (DL-lactide-co-glycolide) Nanoparticles. Research J. Pharm. and Tech. 2019; 12(4): 1529-1535. DOI: 10.5958/0974-360X.2019.00253.1<br>22.    Nozal V, Rojas-Prats E, Maestro I, Gil C, Perez DI, Martinez A. Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles. Int J Mol Sci. 2021; Mar 22; 22(6): 3206. doi: 10.3390/ijms22063206.<br>23.    Mirnezami SMS, Heydarinasab A, Akbarzadehkhyavi A, Adrjmand M. Development and Optimization of Lipid-polymer Hybrid Nanoparticles Containing Melphalan Using Central Composite Design and Its Effect on Ovarian Cancer Cell Lines. Iran J Pharm Res. 2021; Fall; 20(4): 213-228. doi: 10.22037/ijpr.2021.114575.14923..<br>24.    Prajapati, Bhupendra and Paliwal, Himanshu and Patel, Mayuree. (2023). Fabrication and Evaluation of Polymeric Nanoparticles of Acitretin for the Solubility Enhancement. 16. 2655-2660.. 10.52711/0974-360X.2023.00436.<br>25.    Zhou YZ, Alany RG, Chuang V, Wen J. Optimization of PLGA nanoparticles formulation containing L-DOPA by applying the central composite design. Drug Dev Ind Pharm. 2013; Feb; 39(2): 321-30. doi: 10.3109/03639045.2012.681054.<br>26.    Hassan H, Adam SK, Alias E, Meor Mohd Affandi MMR, Shamsuddin AF, Basir R. Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir. Molecules. 2021; Sep 7; 26(18): 5432. doi: 10.3390/molecules26185432.<br>27.    Mahjoub MA, Ebrahimnejad P, Shahlaee F, Ebrahimi P, Sadeghi-Ghadi Z. Preparation and Optimization of Controlled Release Nanoparticles Containing Cefixime Using Central Composite Design: An Attempt to Enrich Its Antimicrobial Activity. Curr Drug Deliv. 2022; 19(3): 369-378. doi: 10.2174/1567201818666210726160956.<br>28.    Bhargav E, Reddy CS, Sowmya C, Haranath C, Khan KA, Rajesh K, Srinath B. Formulation and optimization of piroxicam orodispersible tablets by central composite design. Journal of Young Pharmacists. 2017; 9(2): 187. DOI:10.5530/jyp.2017.9.37<br>29.    Rukmangathen R, Yallamalli IM, Yalavarthi PR. Formulation and biopharmaceutical evaluation of risperidone-loaded chitosan nanoparticles for intranasal delivery. Drug Dev Ind Pharm. 2019; Aug; 45(8): 1342-1350. doi: 10.1080/03639045.2019.1619759.<br>30.    Yadav KS, Sawant KK. Modified nanoprecipitation method for preparation of cytarabine-loaded PLGA nanoparticles. AAPS PharmSciTech. 2010; Sep; 11(3): 1456-65. doi: 10.1208/s12249-010-9519-4<br>31.    Shi W, Zhang ZJ, Yuan Y, Xing EM, Qin Y, Peng ZJ, Zhang ZP, Yang KY. Optimization of parameters for preparation of docetaxel-loaded PLGA nanoparticles by nanoprecipitation method. J Huazhong Univ Sci Technolog Med Sci. 2013; Oct; 33(5): 754-758. doi: 10.1007/s11596-013-1192-x.<br>32.    H. Umamahesvari. Fabrication and Character Study of the Anticancer Drug Paclitaxel (Taxol): PLGA nanoparticles - The benefaction for the modern therapeutic area. Research J. Pharm. and Tech. 2020; 13(1): 265-269. DOI: 10.5958/0974-360X.2020.00054.2<br>33.    Morales-Cruz M, Flores-Fernández GM, Morales-Cruz M, Orellano EA, Rodriguez-Martinez JA, Ruiz M, Griebenow K. Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres. Results Pharma Sci. 2012; 2: 79-85. doi: 10.1016/j.rinphs.2012.11.001.<br>34.    Sivaprasad S, Sadakvali C, Kumar VR, Krishna PM, Yusuf SM, Srikanth A. Formulation and Characterization of Tenofovir Disproxyl Fumerate Nanoparticles prepared by Nanoprecipitation Method. Research Journal of Pharmacy and Technology. 2022; Jul 29; 15(7): 3075-80.10.52711/0974-360X.2022.00514  <br>35.    Marinelli L, Ciulla M, Ritsema JAS, van Nostrum CF, Cacciatore I, Dimmito MP, Palmerio F, Orlando G, Robuffo I, Grande R, Puca V, Di Stefano A. Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles. Pharmaceutics. 2022; Aug 29; 14(9): 1821. doi: 10.3390/pharmaceutics14091821.<br>36.    Tripathi SK, Patel B, Shukla S, Pachouri C, Pathak S, Pandey A. Donepezil loaded PLGA nanoparticles, from modified nano-precipitation, an advanced drug delivery system to treat alzheimer disease. J Phys: Conf Ser. 2021; 1849(1): 012001. doi: 10.1088/1742-6596/1849/1/012001.<br>37.    Irfan M. Saiyyad, D. S. Bhambere, Sanjay Kshirsagar. Formulation and Optimization of Silymarin Loaded PLGA Nanoparticle for liver targeting. Asian J. Pharm. Tech. 2017; 7 (4): 209-220 . DOI: 10.5958/2231-5713.2017.00032.0<br>38.    Jainey P. James, Sneh Priya, Divya Jyothi. Effect of PLGA polymer on Antimicrobial Activity and the Release Studies of Nanoparticle Hydrogel Containing Mimosa pudica Extract. Research J. Pharm. and Tech. 2018; 11(7): 2876-2880. DOI: 10.5958/0974-360X.2018.00530.9<br>39.    R, V. K., and B., J. J. Central composite face-centered design-based optimisation, development and characterisation of favipiravir-loaded plga nanoparticles. International Journal of Applied Pharmaceutics. 2023; 15(1): 234–249. https://doi.org/10.22159/ijap.2023v15i1.46289<br>40.    Kalidas S, Geetha P. 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RJPT - Preparation of Drug Aloin Nanoparticles for Enhanced Bioavailability and Optimization by using a Drug Design Stat-ease software