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Larissa Lelu P. Gata</title> <meta name="description" content="Search results for: Ma. Larissa Lelu P. Gata"> <meta name="keywords" content="Ma. Larissa Lelu P. Gata"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Ma. 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Larissa Lelu P. Gata"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 37</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Ma. Larissa Lelu P. Gata</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">37</span> Microbes at Work: An Assessment on the Use of Microbial Inoculants in Reforestation and Rehabilitation of the Forest Ancestral Land of Magbukun Aytas of Morong, Bataan, Philippines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harold%20M.%20Carag">Harold M. Carag</a>, <a href="https://publications.waset.org/abstracts/search?q=April%20Charmaine%20D.%20Camacho"> April Charmaine D. Camacho</a>, <a href="https://publications.waset.org/abstracts/search?q=Girlie%20Nora%20A.%20Abrigo"> Girlie Nora A. Abrigo</a>, <a href="https://publications.waset.org/abstracts/search?q=Florencia%20G.%20Palis"> Florencia G. Palis</a>, <a href="https://publications.waset.org/abstracts/search?q=Ma.%20Larissa%20Lelu%20P.%20Gata"> Ma. Larissa Lelu P. Gata</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A technology impact assessment on the use of microbial inoculants in the reforestation and rehabilitation of forest ancestral lands of the Magbukün Aytas in Morong, Bataan was conducted. This two-year rainforestation technology aimed to determine the optimum condition for the improvement of seedling survival rate in the nursery and in the field to hasten the process of forest regeneration of Magbukün Ayta’s ancestral land. A combination of qualitative methods (key informant interviews, focus groups and participant observation), participated by the farmers who were directly involved in the project, community men and women, the council of elders and the project staff, was employed to complete this impact assessment. The recorded data were transcribed, and the accounts were broadly categorized on the following aspects: social (gender, institutional, anthropological), economic and environmental. The Australian Center for International Agricultural Research (ACIAR) framework was primarily used for the impact analysis while the Harvard Analytical Framework was specifically used for the gender impact analysis. Through this technology, a wildling nursery with more than one thousand seedlings was successfully established and served as a good area for the healthy growth of seedlings that would be planted in the forest. Results showed that this technology affected positively and negatively the various gender roles present in the community although household work remained to be the women’s responsibility. The technology introduced directly added up to the workload done by the men and women (preparing and applying fertilizer, making pots etc.) but this, in turn, provided ways to increase their sources of livelihood. The gender roles that were already present were further strengthened after the project and men remained to be in control. The technology or project in turn also benefited from the already present roles since they no longer have to assign things to them, the execution of the various roles was smoothly executed. In the anthropological aspect, their assigned task to manage the nursery was an easy responsibility because of their deep connection to the environment and their fear and beliefs on ‘engkato’ and ‘anito’ was helpful in guarding the forest. As the cultural value of these trees increases, their mindset of safeguarding the forest also heightens. Meanwhile, the welfare of the whole tribe is the ultimate determinant of the swift entry of projects. The past institutions brought ephemeral reliefs on the subsistence of the Magbukün Aytas. These were good ‘conditioning’ factors for the adoption of the technology of the project. As an attempt to turn away from the dependent of harmful chemical, the project’s way of introducing organic inputs was slowly gaining popularity in the community. Economically, the project was able to provide additional income to the farmers. However, the slow mode of payment dismayed other farmers and abandoned their roles. Lastly, major environmental effects weren’t that much observed after the application of the technology. The minor effects concentrated more on the improved conditions of the soil and water in the community. Because of the introduced technology, soil conditions became more favorable specifically for the species that were planted. The organic fertilizers used were in turn not harmful for the residents living in Sitio Kanawan. There were no human diseases caused by the technology. The conservation of the biodiversity of the forest is clearly the most evident long-term result of the project. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ancestral%20lands" title="ancestral lands">ancestral lands</a>, <a href="https://publications.waset.org/abstracts/search?q=impact%20assessment" title=" impact assessment"> impact assessment</a>, <a href="https://publications.waset.org/abstracts/search?q=microbial%20inculants" title=" microbial inculants"> microbial inculants</a>, <a href="https://publications.waset.org/abstracts/search?q=reforestation" title=" reforestation"> reforestation</a> </p> <a href="https://publications.waset.org/abstracts/89050/microbes-at-work-an-assessment-on-the-use-of-microbial-inoculants-in-reforestation-and-rehabilitation-of-the-forest-ancestral-land-of-magbukun-aytas-of-morong-bataan-philippines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89050.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> The Influence of the Variety and Harvesting Date on Haskap Composition and Anti-Diabetic Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aruma%20Baduge%20Kithma%20Hansanee%20De%20Silva">Aruma Baduge Kithma Hansanee De Silva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Haskap (Lonicera caerulea L.), also known as blue honeysuckle, is a recently commercialized berry crop in Canada. Haskap berries are rich in polyphenols, including anthocyanins, which are known for potential health-promoting effects. Cyanidin-3-O-glucoside (C3G) is the most prominent anthocyanin of haskap berries. Recent literature reveals the efficacy of C3G in reducing the risk of type 2 diabetes (T2D), which has become an increasingly common health issue around the world. The T2D is characterized as a metabolic disorder of hyperglycemia and insulin resistance. It has been demonstrated that C3G has anti-diabetic effects in various ways, including improvement in insulin sensitivity, and inhibition of activities of carbohydrate-hydrolyzing enzymes, including alpha-amylase and alpha-glucosidase. The goal of this study was to investigate the influence of variety and harvesting date on haskap composition, biological properties, and antidiabetic properties. The polyphenolic compounds present in four commercially grown haskap cultivars, Aurora, Rebecca, Larissa and Evie among five harvesting stages (H1-H5), were extracted separately in 80% ethanol and analyzed to characterize their phenolic profiles. The haskap berries contain different types of polyphenols including flavonoids and phenolic acids. Anthocyanin is the major type of flavonoid. C3G is the most prominent type of anthocyanin, which accounts for 79% of total anthocyanin in all extracts. The variety Larissa at H5 contained the highest average C3G content, and its ethanol extract had the highest (1212.3±63.9 mg/100g FW) while, Evie at H1 contained the lowest C3G content (96.9±40.4 mg/100g FW). The average C3G content of Larissa from H1 – H5 varies from 208 – 1212 mg/100g FW. Quarcetin-3-Rutinoside (Q3Rut) is the major type of flavonol and highest is observed in Rebecca at H4 (47.81 mg/100g FW). The haskap berries also contained phenolic acids, but approximately 95% of the phenolic acids consisted of chlorogenic acid. The cultivar Larissa has a higher level of anthocyanin than the other four cultivars. The highest total phenolic content is observed in Evie at H5 (2.97±1.03 mg/g DW) while the lowest in Rebecca at H1 (1.47±0.96 mg/g DW). The antioxidant capacity of Evie at H5 was higher (14.40±2.21 µmol TE/ g DW) among other cultivars and the lowest observed in Aurora at H3 (5.69±0.34 µmol TE/ g DW). Furthermore, Larissa H5 shows the greatest inhibition of carbohydrate-hydrolyzing enzymes including alpha-glucosidase and alpha-amylase. In conclusion Larissa, at H5 demonstrated highest polyphenol composition and antidiabetic properties. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthocyanin" title="anthocyanin">anthocyanin</a>, <a href="https://publications.waset.org/abstracts/search?q=cyanidin-3-O-glucoside" title=" cyanidin-3-O-glucoside"> cyanidin-3-O-glucoside</a>, <a href="https://publications.waset.org/abstracts/search?q=haskap" title=" haskap"> haskap</a>, <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes" title=" type 2 diabetes"> type 2 diabetes</a> </p> <a href="https://publications.waset.org/abstracts/96371/the-influence-of-the-variety-and-harvesting-date-on-haskap-composition-and-anti-diabetic-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96371.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> The Effect of the Variety and Harvesting Date on Polyphenol Composition of Haskap (Lonicera caerulea L.) and Anti-diabetic Properties of Haskap Polyphenols</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aruma%20Baduge%20Kithma%20De%20Silva">Aruma Baduge Kithma De Silva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Haskap (Lonicera caerulea L.), also known as blue honeysuckle, is a newly commercialized berry crop in Canada. Haskap berries are rich in polyphenols, including, anthocyanins, which are known for potential health-promoting properties. Cyanidin-3-O-glucoside (C3G) is the most abundant anthocyanin of haskap berries. The compound C3G has the ability to reduce the risk of type 2 diabetes (T2D), which has become an increasingly common health issue around the world. The T2D is characterized as a metabolic disorder of hyperglycemia and insulin resistance. It has been demonstrated that C3G has anti-diabetic effects through several ways, including inhibition of dipeptidyl peptidase-4 (DPP-4), reduction of gluconeogenesis, improvement in insulin sensitivity, and inhibition of activities of carbohydrate hydrolyzing enzymes, including α-amylase and α-glucosidase. The goal of this study was to investigate the influence of variety and harvests maturity of haskap on C3G, other fruit quality characteristics and anti-diabetic activities of haskap berries using in vitro studies. The polyphenols present in four commercially grown haskap cultivars, Aurora, Rebecca, Larissa, and Evie harvested at five harvesting dates (H1-H5) apart from 2-3 days, were extracted separately. High-performance liquid chromatography electrospray ionization mass spectrometry (HPLC-ESI-MS) analyzes of polyphenols revealed that haskap berries contain predominantly anthocyanins, flavonols, flavan-3-ols, and phenolic acids. The compound C3G was the most prominent anthocyanin, which is available in approximately 79% of total anthocyanin in four cultivars. The Larissa at H5 contained the highest C3G content. The antioxidant capacity of Evie at H5 was greater than other cultivars. Furthermore, Larissa H5 showed the greatest inhibition of carbohydrate hydrolyzing enzymes including alpha-glucosidase and alpha-amylase. In conclusion, the haskap variety and harvesting date influenced the polyphenol composition and biological properties. The variety Larissa, at H5 harvesting date, contained the highest polyphenol content and the ability of inhibition of the carbohydrate hydrolyzing enzyme as well as DPP4 enzyme in order to reduce type 2 diabetes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthocyanin" title="anthocyanin">anthocyanin</a>, <a href="https://publications.waset.org/abstracts/search?q=Haskap" title=" Haskap"> Haskap</a>, <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes" title=" type 2 diabetes"> type 2 diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenol" title=" polyphenol"> polyphenol</a> </p> <a href="https://publications.waset.org/abstracts/99613/the-effect-of-the-variety-and-harvesting-date-on-polyphenol-composition-of-haskap-lonicera-caerulea-l-and-anti-diabetic-properties-of-haskap-polyphenols" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99613.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> Investigating the Role of Circular RNA GATAD2A on H1N1 Replication </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tianqi%20Yu">Tianqi Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yingnan%20Ding"> Yingnan Ding</a>, <a href="https://publications.waset.org/abstracts/search?q=Yina%20Zhang"> Yina Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yulan%20Liu"> Yulan Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yahui%20Li"> Yahui Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Jing%20Lei"> Jing Lei</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiyong%20Zhou"> Jiyong Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Suquan%20Song"> Suquan Song</a>, <a href="https://publications.waset.org/abstracts/search?q=Boli%20Hu"> Boli Hu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Circular RNAs (circRNAs) play critical roles in various diseases. However, whether and how circular RNA regulates influenza A virus (IAV) infection is unknown. Here, we studied the role of circular RNA GATA Zinc Finger Domain Containing 2A (circ-GATAD2A) in the replication of IAV H1N1 in A549 cells. Circ-GATAD2A was formed upon H1N1 infection. Knockdown of circ-GATAD2A in A549 cells enhanced autophagy and inhibited H1N1 replication. By contrast, overexpression of circ-GATAD2A impaired autophagy and promoted H1N1 replication. Similarly, knockout of vacuolar protein sorting 34 (VPS34) blocked autophagy and increased H1N1 replication. However, the expression of circ-GATAD2A could not further enhance H1N1 replication in VPS34 knockout cells. Collectively, these data indicated that circ-GATAD2A promotes the replication of H1N1 by inhibiting autophagy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autophagy" title="autophagy">autophagy</a>, <a href="https://publications.waset.org/abstracts/search?q=circ-GATAD2A" title=" circ-GATAD2A"> circ-GATAD2A</a>, <a href="https://publications.waset.org/abstracts/search?q=H1N1" title=" H1N1"> H1N1</a>, <a href="https://publications.waset.org/abstracts/search?q=replication" title=" replication"> replication</a> </p> <a href="https://publications.waset.org/abstracts/107831/investigating-the-role-of-circular-rna-gatad2a-on-h1n1-replication" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/107831.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> Women Inclusiveness in Government Leaderships and Public Relations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Kamdjong">Larissa Kamdjong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of this research is to introduce inclusive leadership as a distinct theoretical framework to understand its meaning and functions in advancing gender equality and empowerment in public relations leadership. By proposing women inclusive leadership theoretical model, we explored the roles of inclusive leadership in fostering an organization’s diverse climate and facilitating its practice of participative leadership in empowering women in public relations to reach their full potential in leadership advancement. Moreover, our results confirmed both direct and indirect impacts inclusive leadership could have on women’s perceptions of continued career growth opportunities. Our findings provide theoretical implications and practical solutions to address women’s leadership challenges through an inclusive leadership lens. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=inclusiveness" title="inclusiveness">inclusiveness</a>, <a href="https://publications.waset.org/abstracts/search?q=empowerment" title=" empowerment"> empowerment</a>, <a href="https://publications.waset.org/abstracts/search?q=leadership" title=" leadership"> leadership</a>, <a href="https://publications.waset.org/abstracts/search?q=career%20opportunities" title=" career opportunities"> career opportunities</a> </p> <a href="https://publications.waset.org/abstracts/187041/women-inclusiveness-in-government-leaderships-and-public-relations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187041.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">46</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> Interference of Contaminants in the Characterization of Sugarcane Straw for Energy Purpose</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gabriela%20T.%20Nakashima">Gabriela T. Nakashima</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Larissa%20S.%20Hansted"> Ana Larissa S. Hansted</a>, <a href="https://publications.waset.org/abstracts/search?q=Gabriela%20B.%20Belini"> Gabriela B. Belini</a>, <a href="https://publications.waset.org/abstracts/search?q=Carlos%20R.%20Sette%20Jr"> Carlos R. Sette Jr</a>, <a href="https://publications.waset.org/abstracts/search?q=Hiroyuki%20Yamamoto"> Hiroyuki Yamamoto</a>, <a href="https://publications.waset.org/abstracts/search?q=Fabio%20M.%20Yamaji"> Fabio M. Yamaji</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to determine the interference from contaminants in the characterization of sugarcane straw. The sugarcane straw was collected after the harvest and taken to the drying oven, and then it was crushed in the mill type Willey. Analyzes of ash contents and Klason lignin were done in triplicate and high heating value (HHV) in duplicate, according to ASTM standard. The results obtained for the sugarcane straw were 5.29% for ash content, 29.87% for Klason lignin and 17.67 MJ.kg-1 for HHV. Also, the material was analyzed by scanning electron microscope (SEM). The presence of contaminants was observed, such as silica. The high amount of contaminants in the samples may impact the results of analyzes, also raising its values, for example in the Klason lignin content. These contaminants can also adversely affect the quality of the biomass. Even using the standards is important to know what the purpose of the analysis and care mainly of sampling. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomass" title="biomass">biomass</a>, <a href="https://publications.waset.org/abstracts/search?q=bioenergy" title=" bioenergy"> bioenergy</a>, <a href="https://publications.waset.org/abstracts/search?q=residues" title=" residues"> residues</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20fuel" title=" solid fuel"> solid fuel</a> </p> <a href="https://publications.waset.org/abstracts/49208/interference-of-contaminants-in-the-characterization-of-sugarcane-straw-for-energy-purpose" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49208.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">281</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> Radix Saposhnikoviae Suppresses Allergic Contact Dermatitis in Mice by Regulating DCs Activated Th1-Type Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hailiang%20Liu">Hailiang Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yan%20Ni"> Yan Ni</a>, <a href="https://publications.waset.org/abstracts/search?q=Jie%20Zheng"> Jie Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiaoyan%20Jiang"> Xiaoyan Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Min%20Hong"> Min Hong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Allergic contact dermatitis (ACD) is a commonly clinical type IV allergic skin disease, with the pathological features of infiltration by mononuclear cells and tissue necrosis. Traditional Chinese medicine Radix Saposhnikoviae (RS) is traditionally employed to treat exogenous evils, rubella, itching, rheumatism and tetanus. Meanwhile, it is an important component of the commonly used anti-allergy compound. It’s now widely used as an immuno-modulating agent in mixed herbal decoctions to treat inflammation. However, its mechanism of anti-allergy remains unknown. RS was found to reduce ear thickness, as well as the infiltration of eosinophils. The proliferation of T lymphocytes was inhibited significantly by RS, markedly decreased IFN-γ levels in the supernatant of cells cultured and serum were detected with the treatment of RS. RS significantly decreased the amount of DCs in the mouse lymph nodes, and inhibited the expression of CD4 0 and CD86. Meanwhile, T-bet mRNA expression was down remarkably regulated by RS. These results indicate that RS cures Th1-induced allergic skin inflammation by regulating Th1/Th2 balance with decreasing Th1 differentiation, which might be associated with DCs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=allergic%20contact%20dermatitis" title="allergic contact dermatitis">allergic contact dermatitis</a>, <a href="https://publications.waset.org/abstracts/search?q=Radix%20saposhnikoviae" title=" Radix saposhnikoviae"> Radix saposhnikoviae</a>, <a href="https://publications.waset.org/abstracts/search?q=dendritic%20cells" title=" dendritic cells"> dendritic cells</a>, <a href="https://publications.waset.org/abstracts/search?q=T-bet" title=" T-bet"> T-bet</a>, <a href="https://publications.waset.org/abstracts/search?q=GATA-3" title=" GATA-3"> GATA-3</a>, <a href="https://publications.waset.org/abstracts/search?q=CD4%2B%20CD25%2B%20Foxp3%2B%20treg%20cells" title=" CD4+ CD25+ Foxp3+ treg cells "> CD4+ CD25+ Foxp3+ treg cells </a> </p> <a href="https://publications.waset.org/abstracts/3023/radix-saposhnikoviae-suppresses-allergic-contact-dermatitis-in-mice-by-regulating-dcs-activated-th1-type-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3023.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">374</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> The Buddha in Sophocles’ Tragedy, King Oedipus: An Intertextual Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Newton%20Rathnasiri%20Ranaweera%20Kalu%20Arachchige">Newton Rathnasiri Ranaweera Kalu Arachchige</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Academics argue that Greek myths and legends have had an influence on Buddhist stories: Jataka tales, Theri Gata (Psalms of older Buddhist nuns), and even Mahavansa (a Sri Lankan historical chronicle). However, this article asserts that there is evidence in Sophocles King Oedipus to argue that the Buddha’s life story and key Buddhist concepts have influenced pre-Christian Greek philosophy and literature, especially Sophocles’ King Oedipus. When reading the text with the notion that there could be intertextual relationships or new texts are built on the existing texts and discourses, the reader may see that Sophocles’ play contains incidents that remind them of the special occasions of the Buddha’s life, his utterances and the key Buddhist concepts such as the truth of suffering, cessation of suffering, the three poisons (greed, hatred, and delusion), and finding the truth within one’s own self. The present intertextual study explored only the special occasions of the Buddha’s life to make it more focused and found that Sophocles alludes to the Buddha’s life story in his attempt to raise a moral culprit to a moral hero with higher moral values. This article, however, acknowledges that one needs to cross-check the other historical and philosophical references when claiming that Sophocles has had influence from the Buddha’s life story in King Oedipus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Buddhism" title="Buddhism">Buddhism</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20Buddha%E2%80%99s%20life%20story" title=" the Buddha’s life story"> the Buddha’s life story</a>, <a href="https://publications.waset.org/abstracts/search?q=King%20Oedipus" title=" King Oedipus"> King Oedipus</a>, <a href="https://publications.waset.org/abstracts/search?q=Greece" title=" Greece"> Greece</a>, <a href="https://publications.waset.org/abstracts/search?q=tragedy" title=" tragedy"> tragedy</a>, <a href="https://publications.waset.org/abstracts/search?q=Sri%20Lanka" title=" Sri Lanka"> Sri Lanka</a> </p> <a href="https://publications.waset.org/abstracts/152775/the-buddha-in-sophocles-tragedy-king-oedipus-an-intertextual-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152775.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">109</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> UCP1 Regulates Cardiolipin Metabolism and Mediates Mitochondrial Homeostasis Maintenance of ANXA1 in Diabetic Nephropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zi-Han%20Li">Zi-Han Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Lu%20Fang"> Lu Fang</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Wu"> Liang Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Dong-Yuan%20Chang"> Dong-Yuan Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=Manyuan%20Dong"> Manyuan Dong</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Ji"> Liang Ji</a>, <a href="https://publications.waset.org/abstracts/search?q=Qi%20Zhang"> Qi Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ming-Hui%20Zhao"> Ming-Hui Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Sydney%20C.%20W.%20Tang"> Sydney C. W. Tang</a>, <a href="https://publications.waset.org/abstracts/search?q=Lemin%20Zheng"> Lemin Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Min%20Chen"> Min Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Uncoupling of mitochondrial respiration by chemical uncouplers has proven effective in ameliorating obesity, insulin resistance, and hyperglycemia, which were risk factors for diabetic nephropathy (DN). Recently, we found that ANXA1 could improve mitochondrial function to mitigate DN progression. However, the underlying mechanism is not fully clear yet. Here, we identified uncoupling protein 1 (UCP1), an inner membrane protein of mitochondria, as a key to mitochondrial homeostasis improved by ANXA1. Specifically, ANXA1 attenuated mitochondrial dysfunction via appropriately upregulating UCP1 by stabilizing its transcription factor GATA binding protein 3 (GATA3) by combining it with thioredoxin. Moreover, specific overexpression of UCP1 in the renal cortex rescued renal injuries in diabetic Anxa1-KO mice. UCP1 deletion aggravated renal injuries in HFD/STZ-induced diabetic mice. Mechanistically, UCP1 reduced mitochondrial fission through the aristaless-related homeobox (ARX)/cardiolipin synthase 1 (CRLS1) pathway. Therapeutically, CL316243, a UCP1 agonist, could attenuate established DN in db/db mice. This work established an alternative principle to harness the power of uncouplers for the treatment of DN. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20nephropathy" title="diabetic nephropathy">diabetic nephropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=uncoupling%20protein%201" title=" uncoupling protein 1"> uncoupling protein 1</a>, <a href="https://publications.waset.org/abstracts/search?q=mitochondrial%20homeostasis" title=" mitochondrial homeostasis"> mitochondrial homeostasis</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiolipin%20metabolism" title=" cardiolipin metabolism"> cardiolipin metabolism</a> </p> <a href="https://publications.waset.org/abstracts/178981/ucp1-regulates-cardiolipin-metabolism-and-mediates-mitochondrial-homeostasis-maintenance-of-anxa1-in-diabetic-nephropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/178981.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">74</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> ANXA1 Plays A Nephroprotective Role By Maintaining Mitochondrial Homeostasis Via Upregulating Uncoupling Protein 1 In Diabetic Nephropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zi-Han%20Li">Zi-Han Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Lu%20Fang"> Lu Fang</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Wu"> Liang Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Dong-Yuan%20Chang"> Dong-Yuan Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=Manyuan%20Dong"> Manyuan Dong</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Ji"> Liang Ji</a>, <a href="https://publications.waset.org/abstracts/search?q=Qi%20Zhang"> Qi Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ming-Hui%20Zhao"> Ming-Hui Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Sydney%20C.W.%20Tang"> Sydney C.W. Tang</a>, <a href="https://publications.waset.org/abstracts/search?q=Lemin%20Zheng"> Lemin Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Min%20Chen"> Min Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Uncoupling of mitochondrial respiration by chemical uncouplers has proven effective in ameliorating obesity, insulin resistance, and hyperglycemia, which were risk factors for diabetic nephropathy (DN). Recently, it was found that annexin A1(ANXA1) could improve mitochondrial function to mitigate DN progression. However, the underlying mechanism is not fully clear yet. Here, it was identified that uncoupling protein 1 (UCP1), an inner membrane protein of mitochondria, as a key to mitochondrial homeostasis improved by ANXA1. Specifically, ANXA1 attenuated mitochondrial dysfunction via appropriately upregulating UCP1 by stabilizing its transcription factor GATA binding protein 3 (GATA3) through combining with thioredoxin. Moreover, specific overexpression of UCP1 in renal cortex rescued renal injuries in diabetic Anxa1-KO mice. UCP1 deletion aggravated renal injuries in HFD/STZ-induced diabetic mice. Mechanistically, UCP1 reduced mitochondrial fission through the aristaless-related homeobox (ARX)/cardiolipin synthase 1 (CRLS1) pathway. Therapeutically, CL316243, a UCP1 agonist, could attenuate established DN in db/db mice. This work established a novel principle to harness the power of uncouplers for the treatment of DN. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20nephropathy" title="diabetic nephropathy">diabetic nephropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=uncoupling%20protein%201" title=" uncoupling protein 1"> uncoupling protein 1</a>, <a href="https://publications.waset.org/abstracts/search?q=mitochondrial%20homeostasis" title=" mitochondrial homeostasis"> mitochondrial homeostasis</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiolipin%20metabolism" title=" cardiolipin metabolism"> cardiolipin metabolism</a> </p> <a href="https://publications.waset.org/abstracts/178984/anxa1-plays-a-nephroprotective-role-by-maintaining-mitochondrial-homeostasis-via-upregulating-uncoupling-protein-1-in-diabetic-nephropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/178984.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">83</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Volunteering and Social Integration of Ex-Soviet Immigrants in Israel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Natalia%20Khvorostianov">Natalia Khvorostianov</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Remennick"> Larissa Remennick</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recent immigrants seldom join the ranks of volunteers for various social causes. This gap reflects both material reasons (immigrants’ lower income and lack of free time) and cultural differences (value systems, religiosity, language barrier, attitudes towards host society, etc.). Immigrants from the former socialist countries are particularly averse to organized forms of volunteering for a host of reasons rooted in their past, including the memories of false or forced forms of collectivism imposed by the state. In this qualitative study, based on 21 semi-structured interviews, we explored the perceptions and practices of volunteer work among FSU immigrants - participants in one volunteering project run by an Israeli NGO for the benefit of elderly ex-Soviet immigrants. Our goal was to understand the motivations of immigrant volunteers and the role of volunteering in the processes of their own social and economic integration in their adopted country – Israel. The results indicate that most volunteers chose causes targeting fellow immigrants, their resettlement and well-being, and were motivated by the wish to build co-ethnic support network and overcome marginalization in the Israeli society. Other volunteers were driven by the need for self-actualization in the context of underemployment and occupational downgrading. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=FSU%20immigrants" title="FSU immigrants">FSU immigrants</a>, <a href="https://publications.waset.org/abstracts/search?q=integration" title=" integration"> integration</a>, <a href="https://publications.waset.org/abstracts/search?q=volunteering" title=" volunteering"> volunteering</a>, <a href="https://publications.waset.org/abstracts/search?q=participation" title=" participation"> participation</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20capital" title=" social capital"> social capital</a> </p> <a href="https://publications.waset.org/abstracts/33723/volunteering-and-social-integration-of-ex-soviet-immigrants-in-israel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33723.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">392</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> Elastic and Plastic Collision Comparison Using Finite Element Method</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gustavo%20Rodrigues">Gustavo Rodrigues</a>, <a href="https://publications.waset.org/abstracts/search?q=Hans%20Weber"> Hans Weber</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Driemeier"> Larissa Driemeier</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The prevision of post-impact conditions and the behavior of the bodies during the impact have been object of several collision models. The formulation from Hertz’s theory is generally used dated from the 19<sup>th</sup> century. These models consider the repulsive force as proportional to the deformation of the bodies under contact and may consider it proportional to the rate of deformation. The objective of the present work is to analyze the behavior of the bodies during impact using the Finite Element Method (FEM) with elastic and plastic material models. The main parameters to evaluate are, the contact force, the time of contact and the deformation of the bodies. An advantage of using the FEM approach is the possibility to apply a plastic deformation to the model according to the material definition: there will be used Johnson–Cook plasticity model whose parameters are obtained through empirical tests of real materials. This model allows analyzing the permanent deformation caused by impact, phenomenon observed in real world depending on the forces applied to the body. These results are compared between them and with the model-based Hertz theory. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=collision" title="collision">collision</a>, <a href="https://publications.waset.org/abstracts/search?q=impact%20models" title=" impact models"> impact models</a>, <a href="https://publications.waset.org/abstracts/search?q=finite%20element%20method" title=" finite element method"> finite element method</a>, <a href="https://publications.waset.org/abstracts/search?q=Hertz%20Theory" title=" Hertz Theory"> Hertz Theory</a> </p> <a href="https://publications.waset.org/abstracts/96447/elastic-and-plastic-collision-comparison-using-finite-element-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96447.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">175</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> Evaluation of Energy Upgrade Measures and Connection of Renewable Energy Sources Using Software Tools: Case Study of an Academic Library Building in Larissa, Greece</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giwrgos%20S.%20Gkarmpounis">Giwrgos S. Gkarmpounis</a>, <a href="https://publications.waset.org/abstracts/search?q=Aikaterini%20G.%20Rokkou"> Aikaterini G. Rokkou</a>, <a href="https://publications.waset.org/abstracts/search?q=Marios%20N.%20Moschakis"> Marios N. Moschakis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Increased energy consumption in the academic buildings, creates the need to implement energy saving measures and to take advantage of the renewable energy sources to cover the electrical needs of those buildings. An Academic Library will be used as a case study. With the aid of RETScreen software that takes into account the energy consumptions and characteristics of the Library Building, it is proved that measures such as the replacement of fluorescent lights with led lights, the installation of outdoor shading, the replacement of the openings and Building Management System installation, provide a high level of energy savings. Moreover, given the available space of the building and the climatic data, the installation of a photovoltaic system of 100 kW can also cover a serious amount of the building energy consumption, unlike a wind system that seems uncompromising. Lastly, HOMER software is used to compare the use of a photovoltaic system against a wind system in order to verify the results that came up from the RETScreen software concerning the renewable energy sources. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=building%20sector" title="building sector">building sector</a>, <a href="https://publications.waset.org/abstracts/search?q=energy%20saving%20measures" title=" energy saving measures"> energy saving measures</a>, <a href="https://publications.waset.org/abstracts/search?q=energy%20upgrading" title=" energy upgrading"> energy upgrading</a>, <a href="https://publications.waset.org/abstracts/search?q=homer%20software" title=" homer software"> homer software</a>, <a href="https://publications.waset.org/abstracts/search?q=renewable%20energy%20sources" title=" renewable energy sources"> renewable energy sources</a>, <a href="https://publications.waset.org/abstracts/search?q=RETScreen%20software" title=" RETScreen software"> RETScreen software</a> </p> <a href="https://publications.waset.org/abstracts/85235/evaluation-of-energy-upgrade-measures-and-connection-of-renewable-energy-sources-using-software-tools-case-study-of-an-academic-library-building-in-larissa-greece" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85235.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">229</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> Waste Identification Diagrams Effectiveness: A Case Study in the Manaus Industrial Pole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jos%C3%A9%20Dinis-Carvalho">José Dinis-Carvalho</a>, <a href="https://publications.waset.org/abstracts/search?q=Levi%20Guimar%C3%A3es"> Levi Guimarães</a>, <a href="https://publications.waset.org/abstracts/search?q=Celina%20Le%C3%A3o"> Celina Leão</a>, <a href="https://publications.waset.org/abstracts/search?q=Rui%20Sousa"> Rui Sousa</a>, <a href="https://publications.waset.org/abstracts/search?q=Rosa%20Eliza%20Vieira"> Rosa Eliza Vieira</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Thomaz"> Larissa Thomaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Kelliane%20Guerreiro"> Kelliane Guerreiro</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research paper investigates the efficacy of waste identification diagrams (WIDs) as a tool for waste reduction and management within the Manaus Industrial Pole. The study focuses on assessing the practical application and effectiveness of WIDs in identifying, categorizing, and mitigating various forms of waste generated across industrial processes. Employing a mixed-methods approach, including a qualitative questionnaire applied to 5 companies and quantitative data analysis with SPSS statistical software, the research evaluates the implementation and impact of WIDs on waste reduction practices in select industries within the Manaus Industrial Pole. The findings contribute to understanding the utility of WIDs as a proactive strategy for waste management, offering insights into their potential for fostering sustainable practices and promoting environmental stewardship in industrial settings. The study also discusses challenges, best practices, and recommendations for optimizing the utilization of WIDs in industrial waste management, thereby addressing the broader implications for sustainable industrial development. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=waste%20identification%20diagram" title="waste identification diagram">waste identification diagram</a>, <a href="https://publications.waset.org/abstracts/search?q=value%20stream%20mapping" title=" value stream mapping"> value stream mapping</a>, <a href="https://publications.waset.org/abstracts/search?q=overall%20equipment%20effectiveness" title=" overall equipment effectiveness"> overall equipment effectiveness</a>, <a href="https://publications.waset.org/abstracts/search?q=lean%20manufacturing" title=" lean manufacturing"> lean manufacturing</a> </p> <a href="https://publications.waset.org/abstracts/186058/waste-identification-diagrams-effectiveness-a-case-study-in-the-manaus-industrial-pole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186058.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">54</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> Augmented Reality Using Cuboid Tracking as a Support for Early Stages of Architectural Design</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Negris%20de%20Souza">Larissa Negris de Souza</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Regina%20Mizrahy%20Cuperschmid"> Ana Regina Mizrahy Cuperschmid</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniel%20de%20Carvalho%20Moreira"> Daniel de Carvalho Moreira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Augmented Reality (AR) alters the elaboration of the architectural project, which relates to project cognition: representation, visualization, and perception of information. Understanding these features from the earliest stages of the design can facilitate the study of relationships, zoning, and overall dimensions of the forms. This paper’s goal was to explore a new approach for information visualization during the early stages of architectural design using Augmented Reality (AR). A three-dimensional marker inspired by the Rubik’s Cube was developed, and its performance, evaluated. This investigation interwovens the acquired knowledge of traditional briefing methods and contemporary technology. We considered the concept of patterns (Alexander et al. 1977) to outline geometric forms and associations using visual programming. The Design Science Research was applied to develop the study. An SDK was used in a game engine to generate the AR app. The tool's functionality was assessed by verifying the readability and precision of the reconfigurable 3D marker. The results indicated an inconsistent response. To use AR in the early stages of architectural design the system must provide consistent information and appropriate feedback. Nevertheless, we conclude that our framework sets the ground for looking deep into AR tools for briefing design. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=augmented%20reality" title="augmented reality">augmented reality</a>, <a href="https://publications.waset.org/abstracts/search?q=cuboid%20marker" title=" cuboid marker"> cuboid marker</a>, <a href="https://publications.waset.org/abstracts/search?q=early%20design%20stages" title=" early design stages"> early design stages</a>, <a href="https://publications.waset.org/abstracts/search?q=graphic%20representation" title=" graphic representation"> graphic representation</a>, <a href="https://publications.waset.org/abstracts/search?q=patterns" title=" patterns"> patterns</a> </p> <a href="https://publications.waset.org/abstracts/144742/augmented-reality-using-cuboid-tracking-as-a-support-for-early-stages-of-architectural-design" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144742.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">98</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> Role of Micro-Patterning on Stem Cell-Material Interaction Modulation and Cell Fate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lay%20Poh%20Tan">Lay Poh Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=Chor%20Yong%20Tay"> Chor Yong Tay</a>, <a href="https://publications.waset.org/abstracts/search?q=Haiyang%20Yu"> Haiyang Yu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Micro-contact printing is a form of soft lithography that uses the relief patterns on a master polydimethylsiloxane (PDMS) stamp to form patterns of self-assembled monolayers (SAMs) of ink on the surface of a substrate through conformal contact technique. Here, we adopt this method to print proteins of different dimensions on our biodegradable polymer substrates. We started off with printing 20-500 μm scale lanes of fibronectin to engineer the shape of bone marrow derived human mesenchymal stem cell (hMSCs). After 8 hours of culture, the hMSCs adopted elongated shapes, and upon analysis of the gene expressions, genes commonly associated with myogenesis (GATA-4, MyoD1, cTnT and β-MHC) and neurogenesis (NeuroD, Nestin, GFAP, and MAP2) were up-regulated but gene expression associated to osteogenesis (ALPL, RUNX2, and SPARC) were either down modulated or remained at the nominal level. This is the first evidence that cellular morphology control via micropatterning could be used to modulate stem cell fate without external biochemical stimuli. We further our studies to modulate the focal adhesion (FA) instead of the macro shape of cells. Micro-contact printed islands of different smaller dimensions were investigated. We successfully regulated the FAs into dense FAs and elongated FAs by micropatterning. Additionally, the combined effects of hard (40.4 kPa), and intermediate (10.6 kPa) PA gel and FAs patterning on hMSCs differentiation were studied. Results showed that FA and matrix compliance plays an important role in hMSCs differentiation, and there is a cross-talk between different physical stimulants and the significance of these stimuli can only be realized if they are combined at the optimum level. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=micro-contact%20printing" title="micro-contact printing">micro-contact printing</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer%20substrate" title=" polymer substrate"> polymer substrate</a>, <a href="https://publications.waset.org/abstracts/search?q=cell-material%20interaction" title=" cell-material interaction"> cell-material interaction</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cell%20differentiation" title=" stem cell differentiation"> stem cell differentiation</a> </p> <a href="https://publications.waset.org/abstracts/92615/role-of-micro-patterning-on-stem-cell-material-interaction-modulation-and-cell-fate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92615.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">172</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Development of a Classification Model for Value-Added and Non-Value-Added Operations in Retail Logistics: Insights from a Supermarket Case Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Helena%20Macedo">Helena Macedo</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Tomaz"> Larissa Tomaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Levi%20Guimar%C3%A3es"> Levi Guimarães</a>, <a href="https://publications.waset.org/abstracts/search?q=Lu%C3%ADs%20Cerqueira-Pinto"> Luís Cerqueira-Pinto</a>, <a href="https://publications.waset.org/abstracts/search?q=Jos%C3%A9%20Dinis-Carvalho"> José Dinis-Carvalho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the context of retail logistics, the pursuit of operational efficiency and cost optimization involves a rigorous distinction between value-added and non-value-added activities. In today's competitive market, optimizing efficiency and reducing operational costs are paramount for retail businesses. This research paper focuses on the development of a classification model adapted to the retail sector, specifically examining internal logistics processes. Based on a comprehensive analysis conducted in a retail supermarket located in the north of Portugal, which covered various aspects of internal retail logistics, this study questions the concept of value and the definition of wastes traditionally applied in a manufacturing context and proposes a new way to assess activities in the context of internal logistics. This study combines quantitative data analysis with qualitative evaluations. The proposed classification model offers a systematic approach to categorize operations within the retail logistics chain, providing actionable insights for decision-makers to streamline processes, enhance productivity, and allocate resources more effectively. This model contributes not only to academic discourse but also serves as a practical tool for retail businesses, aiding in the enhancement of their internal logistics dynamics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lean%20retail" title="lean retail">lean retail</a>, <a href="https://publications.waset.org/abstracts/search?q=lean%20logisitcs" title=" lean logisitcs"> lean logisitcs</a>, <a href="https://publications.waset.org/abstracts/search?q=retail%20logistics" title=" retail logistics"> retail logistics</a>, <a href="https://publications.waset.org/abstracts/search?q=value-added%20and%20non-value-added" title=" value-added and non-value-added"> value-added and non-value-added</a> </p> <a href="https://publications.waset.org/abstracts/185235/development-of-a-classification-model-for-value-added-and-non-value-added-operations-in-retail-logistics-insights-from-a-supermarket-case-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/185235.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">66</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> Managerial Advice-Seeking and Supply Chain Resilience: A Social Capital Perspective</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ethan%20Nikookar">Ethan Nikookar</a>, <a href="https://publications.waset.org/abstracts/search?q=Yalda%20Boroushaki"> Yalda Boroushaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Statsenko"> Larissa Statsenko</a>, <a href="https://publications.waset.org/abstracts/search?q=Jorge%20Ochoa%20Paniagua"> Jorge Ochoa Paniagua</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Given the serious impact that supply chain disruptions can have on a firm's bottom-line performance, both industry and academia are interested in supply chain resilience, a capability of the supply chain that enables it to cope with disruptions. To date, much of the research has focused on the antecedents of supply chain resilience. This line of research has suggested various firm-level capabilities that are associated with greater supply chain resilience. A consensus has emerged among researchers that supply chain flexibility holds the greatest potential to create resilience. Supply chain flexibility achieves resilience by creating readiness to respond to disruptions with little cost and time by means of reconfiguring supply chain resources to mitigate the impacts of the disruption. Decisions related to supply chain disruptions are made by supply chain managers; however, the role played by supply chain managers' reference networks has been overlooked in the supply chain resilience literature. This study aims to understand the impact of supply chain managers on their firms' supply chain resilience. Drawing on social capital theory and social network theory, this paper proposes a conceptual model to explore the role of supply chain managers in developing the resilience of supply chains. Our model posits that higher level of supply chain managers' embeddedness in their reference network is associated with increased resilience of their firms' supply chain. A reference network includes individuals from whom supply chain managers seek advice on supply chain related matters. The relationships between supply chain managers' embeddedness in reference network and supply chain resilience are mediated by supply chain flexibility. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=supply%20chain%20resilience" title="supply chain resilience">supply chain resilience</a>, <a href="https://publications.waset.org/abstracts/search?q=embeddedness" title=" embeddedness"> embeddedness</a>, <a href="https://publications.waset.org/abstracts/search?q=reference%20networks" title=" reference networks"> reference networks</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20capitals" title=" social capitals"> social capitals</a> </p> <a href="https://publications.waset.org/abstracts/129140/managerial-advice-seeking-and-supply-chain-resilience-a-social-capital-perspective" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/129140.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">228</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Electrochemical Behavior of Cocaine on Carbon Paste Electrode Chemically Modified with Cu(II) Trans 3-MeO Salcn Complex</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alex%20Soares%20Castro">Alex Soares Castro</a>, <a href="https://publications.waset.org/abstracts/search?q=Matheus%20Manoel%20Teles%20de%20Menezes"> Matheus Manoel Teles de Menezes</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Silva%20de%20Azevedo"> Larissa Silva de Azevedo</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Carolina%20Caleffi%20Patelli"> Ana Carolina Caleffi Patelli</a>, <a href="https://publications.waset.org/abstracts/search?q=Osmair%20Vital%20de%20Oliveira"> Osmair Vital de Oliveira</a>, <a href="https://publications.waset.org/abstracts/search?q=Aline%20Thais%20Bruni"> Aline Thais Bruni</a>, <a href="https://publications.waset.org/abstracts/search?q=Marcelo%20Firmino%20de%20Oliveira"> Marcelo Firmino de Oliveira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Considering the problem of the seizure of illicit drugs, as well as the development of electrochemical sensors using chemically modified electrodes, this work shows the study of the electrochemical activity of cocaine in carbon paste electrode chemically modified with Cu (II) trans 3-MeO salcn complex. In this context, cyclic voltammetry was performed on 0.1 mol.L⁻¹ KCl supporting electrolyte at a scan speed of 100 mV s⁻¹, using an electrochemical cell composed of three electrodes: Ag /AgCl electrode (filled KCl 3 mol.L⁻¹) from Metrohm® (reference electrode); a platinum spiral electrode, as an auxiliary electrode, and a carbon paste electrode chemically modified with Cu (II) trans 3-MeO complex (as working electrode). Two forms of cocaine were analyzed: cocaine hydrochloride (pH 3) and cocaine free base form (pH 8). The PM7 computational method predicted that the hydrochloride form is more stable than the free base form of cocaine, so with cyclic voltammetry, we found electrochemical signal only for cocaine in the form of hydrochloride, with an anodic peak at 1.10 V, with a linearity range between 2 and 20 μmol L⁻¹ had LD and LQ of 2.39 and 7.26x10-5 mol L⁻¹, respectively. The study also proved that cocaine is adsorbed on the surface of the working electrode, where through an irreversible process, where only anode peaks are observed, we have the oxidation of cocaine, which occurs in the hydrophilic region due to the loss of two electrons. The mechanism of this reaction was confirmed by the ab-inito quantum method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ab-initio%20computational%20method" title="ab-initio computational method">ab-initio computational method</a>, <a href="https://publications.waset.org/abstracts/search?q=analytical%20method" title=" analytical method"> analytical method</a>, <a href="https://publications.waset.org/abstracts/search?q=cocaine" title=" cocaine"> cocaine</a>, <a href="https://publications.waset.org/abstracts/search?q=Schiff%20base%20complex" title=" Schiff base complex"> Schiff base complex</a>, <a href="https://publications.waset.org/abstracts/search?q=voltammetry" title=" voltammetry"> voltammetry</a> </p> <a href="https://publications.waset.org/abstracts/93544/electrochemical-behavior-of-cocaine-on-carbon-paste-electrode-chemically-modified-with-cuii-trans-3-meo-salcn-complex" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93544.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">194</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Cybersecurity Challenges in Africa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chimmoe%20Fomo%20Michelle%20Larissa">Chimmoe Fomo Michelle Larissa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The challenges of cybersecurity in Africa are increasingly significant as the continent undergoes rapid digital transformation. With the rise of internet connectivity, mobile phone usage, and digital financial services, Africa faces unique cybersecurity threats. The significance of this study lies in understanding these threats and the multifaceted challenges that hinder effective cybersecurity measures across the continent. The methodologies employed in this study include a comprehensive analysis of existing cybersecurity frameworks in various African countries, surveys of key stakeholders in the digital ecosystem, and case studies of cybersecurity incidents. These methodologies aim to provide a detailed understanding of the current cybersecurity landscape, identify gaps in existing policies, and evaluate the effectiveness of implemented security measures. Major findings of the study indicate that Africa faces numerous cybersecurity challenges, including inadequate regulatory frameworks, insufficient cybersecurity awareness, and a shortage of skilled professionals. Additionally, the prevalence of cybercrime, such as financial fraud, data breaches, and ransomware attacks, exacerbates the situation. The study also highlights the role of international cooperation and regional collaboration in addressing these challenges and improving overall cybersecurity resilience. In conclusion, addressing cybersecurity challenges in Africa requires a multifaceted approach that involves strengthening regulatory frameworks, enhancing public awareness, and investing in cybersecurity education and training. The study underscores the importance of regional and international collaboration in building a robust cybersecurity infrastructure capable of mitigating the risks associated with the continent's digital growth. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Africa" title="Africa">Africa</a>, <a href="https://publications.waset.org/abstracts/search?q=cybersecurity" title=" cybersecurity"> cybersecurity</a>, <a href="https://publications.waset.org/abstracts/search?q=challenges" title=" challenges"> challenges</a>, <a href="https://publications.waset.org/abstracts/search?q=digital%20infrastructure" title=" digital infrastructure"> digital infrastructure</a>, <a href="https://publications.waset.org/abstracts/search?q=cybercrime" title=" cybercrime"> cybercrime</a> </p> <a href="https://publications.waset.org/abstracts/187065/cybersecurity-challenges-in-africa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187065.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">40</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Subclinical Renal Damage Induced by High-Fat Diet in Young Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Larissa%20M.%20Vargas">Larissa M. Vargas</a>, <a href="https://publications.waset.org/abstracts/search?q=Julia%20M.%20Sacchi"> Julia M. Sacchi</a>, <a href="https://publications.waset.org/abstracts/search?q=Renata%20O.%20Pereira"> Renata O. Pereira</a>, <a href="https://publications.waset.org/abstracts/search?q=Lucas%20%20S.%20Asano"> Lucas S. Asano</a>, <a href="https://publications.waset.org/abstracts/search?q=Iara%20C.%20Ara%C3%BAjo"> Iara C. Araújo</a>, <a href="https://publications.waset.org/abstracts/search?q=Patricia%20Fiorino"> Patricia Fiorino</a>, <a href="https://publications.waset.org/abstracts/search?q=Vera%20Farah"> Vera Farah </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to evaluate the occurrence of subclinical organ injuries induced by high-fat diet. Male wistar rats (n=5/group) were divided in control diet group (CD), commercial rat chow, and hyperlipidic diet (30% lipids) group (HD) administrated during 8 weeks, starting after weaning. All the procedures followed the rules of the Committee of Research and Ethics of the Mackenzie University (CEUA Nº 077/03/2011). At the end of protocol the animals were euthanized by anesthesia overload and the left kidney was removed. Intrarenal lipid deposition was evaluated by histological analyses with oilred. Kidney slices were stained with picrosirius red to evaluate the area of the Bowman's capsule (AB) and space (SB), and glomerular tuft area (GT). The renal expression of sterol regulatory element–binding protein (SREBP-2) was performed by Western Blotting. Creatinine concentration (serum and urine) and lipid profile were determined by colorimetric kit (Labtest). At the end of the protocol there was no differences in body weight between the groups, however the HD showed a marked increase in lipid deposits, glomeruli and tubules, and biochemical analysis for cholesterol and triglycerides. Moreover, in the kidney, the high-fat diet induced a reduction in the AB (13%), GT (18%) and SB (17%) associated with a reduction in glomerular filtration rate (creatinine clearance). The renal SRBP2 expression was increased in HD group. These data suggests that consumption of high-fat diet starting in childhood is associated with subclinical renal damage and function. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=high-fat%20diet" title="high-fat diet">high-fat diet</a>, <a href="https://publications.waset.org/abstracts/search?q=kidney" title=" kidney"> kidney</a>, <a href="https://publications.waset.org/abstracts/search?q=intrarenal%20lipid%20deposition" title=" intrarenal lipid deposition"> intrarenal lipid deposition</a>, <a href="https://publications.waset.org/abstracts/search?q=SRBP2" title=" SRBP2"> SRBP2</a> </p> <a href="https://publications.waset.org/abstracts/46670/subclinical-renal-damage-induced-by-high-fat-diet-in-young-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46670.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Factors Associated with Non-Adherence to Antiretroviral Treatment among HIV Infected Patients in Ukraine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Burruano">Larissa Burruano</a>, <a href="https://publications.waset.org/abstracts/search?q=Sergey%20Grabovyj"> Sergey Grabovyj</a>, <a href="https://publications.waset.org/abstracts/search?q=Irina%20Nguen"> Irina Nguen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study aimed to assess the level of adherence to anti retroviral therapy (ART) and to examine the relationship between adherence and risk behavior factor (drug use) among patients infected with HIV. The patients with newly diagnosed or established HIV infection under follow-up at the Sumskij Regional Centre for AIDS Prevention in Ukraine were eligible for this study. Medical records were used to measure the patient’s adherence to medication. Measurements were obtained at month 6 and at month 12 to calculate the number of medication omission during the past 30 days: (on a 2-point scale – once until three in a month – were considered adherent, three and more in a month – were considered non-adherent). Of the 50 study participants, 27 (54.0%) were men and 23 (46.0%) women. The mean age is 35.2 years (SD= 5.1). A majority of the patients (82.0%) is in the age group of 25-30 years. The main level of adherence was 74.0% and 66.0% at 6 and 12 months, respectively. The main routes of HIV transmission were drug injection among men 12 (44.4%) and sexual contact among women 11 (47.8%). Univariate analyses indicated that patients who had lower level of education were more likely to have been non-adherent at month 6- (X2 =5.1, n=50, p < .05) and at month 12 (X2 = 4.34, n=50, p < .05). Multivariate tests showed that only age (OR= 1.163 [95% CI 0.98–1.370]) was significant independent predictor of treatment adherence, while gender, education, employment status were not predictive for the risk of developing non-compliance. There was not a significant interaction between non-adherence and intravenous drug use. Consistent with these findings, younger people were more likely to have missed a dose of their medication because they had a greater sense of invulnerability than older patients. The study indicates that the socio demographic characteristic should be taken into an account in the future research regarding adherence in the case of HIV infection. If the patient anti retroviral adherence can be improved by qualitatively better medical care in all regions of the Ukraine, behavioral changes in the population can to be expected in the long term. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HIV" title="HIV">HIV</a>, <a href="https://publications.waset.org/abstracts/search?q=antiretroviral%20therapy" title=" antiretroviral therapy"> antiretroviral therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=adherence" title=" adherence"> adherence</a>, <a href="https://publications.waset.org/abstracts/search?q=Ukraine" title=" Ukraine"> Ukraine</a>, <a href="https://publications.waset.org/abstracts/search?q=Eastern%20Europe" title=" Eastern Europe"> Eastern Europe</a> </p> <a href="https://publications.waset.org/abstracts/20477/factors-associated-with-non-adherence-to-antiretroviral-treatment-among-hiv-infected-patients-in-ukraine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20477.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">289</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Health Literacy and Knowledge Related to Tuberculosis among Outpatients at a Referral Hospital in Lima, Peru</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rosalina%20Penaloza">Rosalina Penaloza</a>, <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Navarro"> Joanna Navarro</a>, <a href="https://publications.waset.org/abstracts/search?q=Pauline%20Jolly"> Pauline Jolly</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20Junkins"> Anna Junkins</a>, <a href="https://publications.waset.org/abstracts/search?q=Carlos%20Seas"> Carlos Seas</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Otero"> Larissa Otero</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Tuberculosis (TB) case detection in Peru relies on passive case finding. This strategy relies on the assumption that the community is aware that a persistent cough is a possible symptom of TB and that formal health care needs to be sought. Despite its importance, health knowledge specific to TB is underexplored in Peru. This study aimed to assess health literacy and level of TB knowledge among outpatients attending a referral hospital in Lima, Peru. The goal was to ascertain knowledge gaps in key areas relating to TB, to identify and prioritize subgroups for intervention, and to provide insight for policy and community interventions considering health literacy. Methods: An observational cross-sectional study was conducted using a survey to measure sociodemographic factors, tuberculosis knowledge, and health literacy. Bivariate and Multivariate logistic regression was performed to study the associations between variables and to account for potential confounders. The study was conducted at Hospital Cayetano Heredia in Lima, Peru from June – August 2017. Results: 272 participants were included in the analysis. 57.7% knew someone who had had TB before, 9% had had TB in the past. Two weeks a cough was correctly identified as a symptom that could be TB by 69.1%. High TB knowledge was found among 149 (54.8%) participants. High health literacy was found among 193 (71.0%) participants. Health literacy and TB knowledge were not significantly associated (OR 0.9 (95%CI 0.5-1.5)). After controlling for sex, age, district, education, health insurance, frequency of hospital visits and previous TB diagnosis: High TB knowledge was associated with knowing someone with TB (aOR 2.7 (95%CI 1.6-4.7)) and being a public transport driver, (aOR 0.2 (95%CI 0.05-0.9)). Not being poor was the single factor associated with high health literacy (aOR 3.8 (95%CI 1.6-8.9)). Conclusions: TB knowledge was fair, though 30% did not know the most important symptom of TB. Tailoring educational strategies to risk groups may enhance passive case detection especially amongst transport workers in Lima, Peru. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=health%20literacy" title="health literacy">health literacy</a>, <a href="https://publications.waset.org/abstracts/search?q=Peru" title=" Peru"> Peru</a>, <a href="https://publications.waset.org/abstracts/search?q=tuberculosis" title=" tuberculosis"> tuberculosis</a>, <a href="https://publications.waset.org/abstracts/search?q=tuberculosis%20knowledge" title=" tuberculosis knowledge"> tuberculosis knowledge</a> </p> <a href="https://publications.waset.org/abstracts/89351/health-literacy-and-knowledge-related-to-tuberculosis-among-outpatients-at-a-referral-hospital-in-lima-peru" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89351.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">505</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Leukocyte Transcriptome Analysis of Patients with Obesity-Related High Output Heart Failure</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samantha%20A.%20Cintron">Samantha A. Cintron</a>, <a href="https://publications.waset.org/abstracts/search?q=Janet%20Pierce"> Janet Pierce</a>, <a href="https://publications.waset.org/abstracts/search?q=Mihaela%20E.%20Sardiu"> Mihaela E. Sardiu</a>, <a href="https://publications.waset.org/abstracts/search?q=Diane%20Mahoney"> Diane Mahoney</a>, <a href="https://publications.waset.org/abstracts/search?q=Jill%20Peltzer"> Jill Peltzer</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhanu%20Gupta"> Bhanu Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Qiuhua%20Shen"> Qiuhua Shen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> High output heart failure (HOHF) is characterized a high output state resulting from an underlying disease process and is commonly caused by obesity. As obesity levels increase, more individuals will be at risk for obesity-related HOHF. However, the underlying pathophysiologic mechanisms of obesity-related HOHF are not well understood and need further research. The aim of the study was to describe the differences in leukocyte transcriptomes of morbidly obese patients with HOHF and those with non-HOHF. In this cross-sectional study, the study team collected blood samples, demographics, and clinical data of six patients with morbid obesity and HOHF and six patients with morbid obesity and non-HOHF. The study team isolated the peripheral blood leukocyte RNA and applied stranded total RNA sequencing. Differential gene expression was calculated, and Ingenuity Pathway Analysis software was used to interpret the canonical pathways, functional changes, upstream regulators, and mechanistic and causal networks that were associated with the significantly different leukocyte transcriptomes. The study team identified 116 differentially expressed genes; 114 were upregulated, and 2 were downregulated in the HOHF group (Benjamini-Hochberg adjusted p-value ≤ 0.05 and log2(fold-change) of ±1). The differentially expressed genes were involved with cell proliferation, mitochondrial function, erythropoiesis, erythrocyte stability, and apoptosis. The top upregulated canonical pathways associated with differentially expressed genes were autophagy, adenosine monophosphate-activated protein kinase signaling, and senescence pathways. Upstream regulator GATA Binding Protein 1 (GATA1) and a network associated with nuclear factor kappa-light chain-enhancer of activated B cells (NF-kB) were also identified based on the different leukocyte transcriptomes of morbidly obese patients with HOHF and non-HOHF. To the author’s best knowledge, this is the first study that reported the differential gene expression in patients with obesity-related HOHF and demonstrated the unique pathophysiologic mechanisms underlying the disease. Further research is needed to determine the role of cellular function and maintenance, inflammation, and iron homeostasis in obesity-related HOHF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cardiac%20output" title="cardiac output">cardiac output</a>, <a href="https://publications.waset.org/abstracts/search?q=heart%20failure" title=" heart failure"> heart failure</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=transcriptomics" title=" transcriptomics"> transcriptomics</a> </p> <a href="https://publications.waset.org/abstracts/173588/leukocyte-transcriptome-analysis-of-patients-with-obesity-related-high-output-heart-failure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173588.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">55</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Comparison of Cardiomyogenic Potential of Amniotic Fluid Mesenchymal Stromal Cells Derived from Normal and Isolated Congenital Heart Defective Fetuses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manali%20Jain">Manali Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Neeta%20Singh"> Neeta Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Raunaq%20Fatima"> Raunaq Fatima</a>, <a href="https://publications.waset.org/abstracts/search?q=Soniya%20Nityanand"> Soniya Nityanand</a>, <a href="https://publications.waset.org/abstracts/search?q=Mandakini%20Pradhan"> Mandakini Pradhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Chandra%20Prakash%20Chaturvedi"> Chandra Prakash Chaturvedi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Isolated Congenital Heart Defect (ICHD) is the major cause of neonatal death worldwide among all forms of CHDs. A significant proportion of fetuses with ICHD die in the neonatal period if no treatment is provided. Recently, stem cell therapies have emerged as a potential approach to ameliorate ICHD in children. ICHD is characterized by cardiac structural abnormalities during embryogenesis due to alterations in the cardiomyogenic properties of a pool of cardiac progenitors/ stem cells associated with fetal heart development. The stem cells present in the amniotic fluid (AF) are of fetal origin and may reflect the physiological and pathological changes in the fetus during embryogenesis. Therefore, in the present study, the cardiomyogenic potential of AF-MSCs derived from fetuses with ICHD (ICHD AF-MSCs) has been evaluated and compared with that of AF-MSCs of structurally normal fetuses (normal AF-MSCs). Normal and ICHD AF-MSC were analyzed for the expression of cardiac progenitor markers viz., stage-specific embryonic antigen-1 (SSEA-1), vascular endothelial growth factor 2 (VEGFR-2) and platelet-derived growth factor receptor-alpha (PDGFR-α) by flow cytometry. The immunophenotypic characterization revealed that ICHD AF-MSCs have significantly lower expression of cardiac progenitor markers VEGFR-2 (0.14% ± 0.6 vs.48.80% ± 0.9; p <0.01), SSEA-1 (70.86% ± 2.4 vs. 88.36% ±2.7; p <0.01), and PDGFR-α (3.92% ± 1.8 vs. 47.59% ± 3.09; p <0.01) in comparison to normal AF-MSCs. Upon induction with 5’-azacytidine for 21 days, ICHD AF-MSCs showed a significantly down-regulated expression of cardiac transcription factors such as GATA-4 (0.4 ± 0.1 vs. 6.8 ± 1.2; p<0.01), ISL-1 (2.3± 0.6 vs. 14.3 ± 1.12; p<0.01), NK-x 2-5 (1.1 ± 0.3 vs. 14.1 ±2.8; p<0.01), TBX-5 (0.4 ± 0.07 vs. 4.4 ± 0.3; p<0.001), and TBX-18 (1.3 ± 0.2 vs. 4.19 ± 0.3; p<0.01) when compared with the normal AF-MSCs. Furthermore, immunocytochemical staining revealed that both types of AF-MSCs could differentiate into cardiovascular lineages and express cardiomyogenic, endothelial, and smooth muscle actin markers, viz., cardiac troponin (cTNT), CD31, and alpha-smooth muscle actin (α-SMA). However, normal AF-MSCs showed an enhanced expression of cTNT (p<0.001), CD31 (p<0.01), and α-SMA (p<0.05), compared to ICHD AF-MSCs. Overall, these results suggest that the ICHD-AF-MSCs have a defective cardiomyogenic differentiation potential and that the defects in these stem cells may have a role in the pathogenesis of ICHD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amniotic%20fluid" title="amniotic fluid">amniotic fluid</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiomyogenic%20potential" title=" cardiomyogenic potential"> cardiomyogenic potential</a>, <a href="https://publications.waset.org/abstracts/search?q=isolated%20congenital%20heart%20defect" title=" isolated congenital heart defect"> isolated congenital heart defect</a>, <a href="https://publications.waset.org/abstracts/search?q=mesenchymal%20stem%20cells" title=" mesenchymal stem cells"> mesenchymal stem cells</a> </p> <a href="https://publications.waset.org/abstracts/148355/comparison-of-cardiomyogenic-potential-of-amniotic-fluid-mesenchymal-stromal-cells-derived-from-normal-and-isolated-congenital-heart-defective-fetuses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/148355.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">102</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Disentangling the Sources and Context of Daily Work Stress: Study Protocol of a Comprehensive Real-Time Modelling Study Using Portable Devices</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Bolliger">Larissa Bolliger</a>, <a href="https://publications.waset.org/abstracts/search?q=Juno%C5%A1%20Lukan"> Junoš Lukan</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitja%20Lustrek"> Mitja Lustrek</a>, <a href="https://publications.waset.org/abstracts/search?q=Dirk%20De%20Bacquer"> Dirk De Bacquer</a>, <a href="https://publications.waset.org/abstracts/search?q=Els%20Clays"> Els Clays</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction and Aim: Chronic workplace stress and its health-related consequences like mental and cardiovascular diseases have been widely investigated. This project focuses on the sources and context of psychosocial daily workplace stress in a real-world setting. The main objective is to analyze and model real-time relationships between (1) psychosocial stress experiences within the natural work environment, (2) micro-level work activities and events, and (3) physiological signals and behaviors in office workers. Methods: An Ecological Momentary Assessment (EMA) protocol has been developed, partly building on machine learning techniques. Empatica® wristbands will be used for real-life detection of stress from physiological signals; micro-level activities and events at work will be based on smartphone registrations, further processed according to an automated computer algorithm. A field study including 100 office-based workers with high-level problem-solving tasks like managers and researchers will be implemented in Slovenia and Belgium (50 in each country). Data mining and state-of-the-art statistical methods – mainly multilevel statistical modelling for repeated data – will be used. Expected Results and Impact: The project findings will provide novel contributions to the field of occupational health research. While traditional assessments provide information about global perceived state of chronic stress exposure, the EMA approach is expected to bring new insights about daily fluctuating work stress experiences, especially micro-level events and activities at work that induce acute physiological stress responses. The project is therefore likely to generate further evidence on relevant stressors in a real-time working environment and hence make it possible to advise on workplace procedures and policies for reducing stress. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ecological%20momentary%20assessment" title="ecological momentary assessment">ecological momentary assessment</a>, <a href="https://publications.waset.org/abstracts/search?q=real-time" title=" real-time"> real-time</a>, <a href="https://publications.waset.org/abstracts/search?q=stress" title=" stress"> stress</a>, <a href="https://publications.waset.org/abstracts/search?q=work" title=" work"> work</a> </p> <a href="https://publications.waset.org/abstracts/96962/disentangling-the-sources-and-context-of-daily-work-stress-study-protocol-of-a-comprehensive-real-time-modelling-study-using-portable-devices" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96962.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">161</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Visual Preferences of Elementary School Children with Autism Spectrum Disorder: An Experimental Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Larissa%20Pliska">Larissa Pliska</a>, <a href="https://publications.waset.org/abstracts/search?q=Isabel%20Neitzel"> Isabel Neitzel</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20Buscherm%C3%B6hle"> Michael Buschermöhle</a>, <a href="https://publications.waset.org/abstracts/search?q=Olga%20Kunina-Habenicht"> Olga Kunina-Habenicht</a>, <a href="https://publications.waset.org/abstracts/search?q=Ute%20Ritterfeld"> Ute Ritterfeld</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Visual preferences, which can be assessed using eye tracking technologies, are considered one of the defining hallmarks of Autism Spectrum Disorder (ASD). Specifically, children with ASD show a decreased preference for social images rather than geometric images compared to typically developed (TD) children. Such differences are already prevalent at a very early age and indicate the severity of the disorder: toddlers with ASD who preferred geometric images when confronted with social and geometric images showed higher ASD symptom severity than toddlers with ASD who showed higher social attention. Furthermore, the complexity of social pictures (one child playing vs. two children playing together) as well as the mode of stimulus presentation (video or image), are not decisive for the marker. The average age of diagnosis for ASD in Germany is 6.5 years, and visual preference data on this age group is missing. In the present study, we therefore investigated whether visual preferences persist into school age. We examined the visual preferences of 16 boys aged 6 to 11 with ASD and unimpaired cognition as well as TD children (1:1 matching based on children's age and the parent's level of education) within an experimental setting. Different stimulus presentation formats (images vs. videos) and different levels of stimulus complexity were included. Children with and without ASD received pairs of social and non-social images and video stimuli on a screen while eye movements (i.e., eye position and gaze direction) were recorded. For this specific use case, KIZMO GmbH developed a customized, native iOS app (KIZMO Face-Analyzer) for use on iPads. Neither the format of stimulus presentation nor the complexity of the social images had a significant effect on the visual preference of children with and without ASD in this study. Despite the tendency for a difference between the groups for the video stimuli, there were no significant differences. Overall, no statistical differences in visual preference occurred between boys with and without ASD, suggesting that gaze preference in these groups is similar at primary school age. One limitation is that the children with ASD were already receiving Autism-specific intervention. The potential of a visual preference task as an indicator of ASD can be emphasized. The article discusses the clinical relevance of this marker in elementary school children. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autism%20spectrum%20disorder" title="autism spectrum disorder">autism spectrum disorder</a>, <a href="https://publications.waset.org/abstracts/search?q=eye%20tracking" title=" eye tracking"> eye tracking</a>, <a href="https://publications.waset.org/abstracts/search?q=hallmark" title=" hallmark"> hallmark</a>, <a href="https://publications.waset.org/abstracts/search?q=visual%20preference" title=" visual preference"> visual preference</a> </p> <a href="https://publications.waset.org/abstracts/179288/visual-preferences-of-elementary-school-children-with-autism-spectrum-disorder-an-experimental-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/179288.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">60</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Assessing Local Authorities’ Interest in Addressing Urban Challenges through Nature Based Solutions in Romania</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Athanasios%20A.%20Gavrilidis">Athanasios A. Gavrilidis</a>, <a href="https://publications.waset.org/abstracts/search?q=Mihai%20R.%20Nita"> Mihai R. Nita</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20N.%20Stoia"> Larissa N. Stoia</a>, <a href="https://publications.waset.org/abstracts/search?q=Diana%20A.%20Onose"> Diana A. Onose</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Contemporary global environmental challenges must be primarily addressed at local levels. Cities are under continuous pressure as they must ensure high quality of life levels for their citizens and at the same time to adapt and address specific environmental issues. Innovative solutions using natural features or mimicking natural systems are endorsed by the scientific community as efficient approaches for both mitigating climate change effects and the decrease of environmental quality and for maintaining high standards of living for urban dwellers. The aim of this study was to assess whether Romanian cities’ authorities are considering nature-based innovation as solutions for their planning, management, and environmental issues. Data were gathered by applying 140 questionnaires to urban authorities throughout the country. The questionnaire was designed for assessinglocal policy makers’ perspective over the efficiency of nature-based innovations as a tool to address specific challenges. It also focused on extracting data about financing sources and challenges they must overcome for adopting nature-based approaches. The gather results from the municipalities participating in our study were statistically processed, and they revealed that Romanian city managers acknowledge the benefits of nature-based innovations, but investments in this sector are not on top of their priorities. More than 90% of the selected cities have agreed that in the last 10 years, their major concern was to expand the grey infrastructure (roads and public amenities) using traditional approaches. When asked how they would react if faced with different socio-economic and environmental challenges, local urban managers indicated investments nature-based solutions as a priority only in case of biodiversity loss and extreme weather, while for other 14 proposed scenarios, they would embrace the business-as-usual approach. Our study indicates that while new concepts of sustainable urban planning emerge within the scientific community, local authorities need more time to understand and implement them. Without the proper knowledge, personnel, policies, or dedicated budgets, local administrators will not embrace nature-based innovations as solutions for their challenges. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nature%20based%20innovations" title="nature based innovations">nature based innovations</a>, <a href="https://publications.waset.org/abstracts/search?q=perception%20analysis" title=" perception analysis"> perception analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=policy%20making" title=" policy making"> policy making</a>, <a href="https://publications.waset.org/abstracts/search?q=urban%20planning" title=" urban planning"> urban planning</a> </p> <a href="https://publications.waset.org/abstracts/145889/assessing-local-authorities-interest-in-addressing-urban-challenges-through-nature-based-solutions-in-romania" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145889.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">174</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Association of Sleep Duration and Insomnia with Body Mass Index Among Brazilian Adults</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giovana%20Longo-Silva">Giovana Longo-Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Risia%20Cristina%20Egito%20de%20Menezes"> Risia Cristina Egito de Menezes</a>, <a href="https://publications.waset.org/abstracts/search?q=Renan%20Serenini"> Renan Serenini</a>, <a href="https://publications.waset.org/abstracts/search?q=M%C3%A1rcia%20de%20Oliveira%20Lima"> Márcia de Oliveira Lima</a>, <a href="https://publications.waset.org/abstracts/search?q=J%C3%BAlia%20Souza%20de%20Melo"> Júlia Souza de Melo</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20de%20Lima%20Soares"> Larissa de Lima Soares</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Sleep duration and quality have been increasingly recognized as important factors affecting overall health and well-being, including their potential impact on body weight and composition. Previous research has shown inconsistent results regarding the association between sleep patterns and body mass index (BMI), particularly among diverse populations such as Brazilian adults. Understanding these relationships is crucial for developing targeted interventions to address obesity and related health issues. Objective: This study aimed to investigate the association between sleep duration, insomnia, and BMI among Brazilian adults using data from a large national survey focused on chronic nutrition and sleep habits. Materials and Methods: The study included 2050 participants from a population-based virtual survey. BMI was calculated using self-reported weight and height measurements. Participants also reported usual bedtime and wake time on weekdays and weekends and whether they experienced symptoms of insomnia. The average sleep duration across the entire week was calculated as follows: [(5×sleep duration on weekdays) + (2×sleep duration on weekends)]/7. Linear regression analyses were conducted to assess the association between sleep duration, insomnia, and BMI, adjusting for potential confounding factors, including age, sex, marital status, physical exercise duration, and diet quality. Results: After adjusting for confounding variables, the study found that BMI decreased by 0.19 kg/m² for each additional hour of sleep duration (95% CI = -0.37, -0.02; P = 0.03). Conversely, individuals with insomnia had a higher BMI, with an increase of 0.75 kg/m² (95% CI = 0.28, 1.22; P = 0.002) compared to those without insomnia. Conclusions: The findings suggest a significant association between sleep duration, insomnia, and BMI among Brazilian adults. Longer sleep duration was associated with lower BMI, while insomnia was associated with higher BMI. These results underscore the importance of considering sleep patterns in strategies aimed at preventing and managing obesity in this population. Further research is needed to explore the underlying mechanisms and potential interventions targeting sleep-related factors to promote healthier body weight outcomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sleep" title="sleep">sleep</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=chronobiology" title=" chronobiology"> chronobiology</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrition" title=" nutrition"> nutrition</a> </p> <a href="https://publications.waset.org/abstracts/186449/association-of-sleep-duration-and-insomnia-with-body-mass-index-among-brazilian-adults" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186449.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">44</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Obtainment of Systems with Efavirenz and Lamellar Double Hydroxide as an Alternative for Solubility Improvement of the Drug</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Danilo%20A.%20F.%20Fontes">Danilo A. F. Fontes</a>, <a href="https://publications.waset.org/abstracts/search?q=Magaly%20A.%20M.Lyra"> Magaly A. M.Lyra</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20L.%20C.%20Moura"> Maria L. C. Moura</a>, <a href="https://publications.waset.org/abstracts/search?q=Leslie%20R.%20M.%20Ferraz"> Leslie R. M. Ferraz</a>, <a href="https://publications.waset.org/abstracts/search?q=Salvana%20P.%20M.%20Costa"> Salvana P. M. Costa</a>, <a href="https://publications.waset.org/abstracts/search?q=Amanda%20C.%20Q.%20M.%20Vieira"> Amanda C. Q. M. Vieira</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20A.%20Rolim"> Larissa A. Rolim</a>, <a href="https://publications.waset.org/abstracts/search?q=Giovanna%20C.%20R.%20M.%20Schver"> Giovanna C. R. M. Schver</a>, <a href="https://publications.waset.org/abstracts/search?q=Ping%20I.%20Lee"> Ping I. Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Severino%20Alves-J%C3%BAnior"> Severino Alves-Júnior</a>, <a href="https://publications.waset.org/abstracts/search?q=Jos%C3%A9%20L.%20Soares-Sobrinho"> José L. Soares-Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=Pedro%20J.%20Rolim-Neto"> Pedro J. Rolim-Neto </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Efavirenz (EFV) is a first-choice drug in antiretroviral therapy with high efficacy in the treatment of infection by Human Immunodeficiency Virus, which causes Acquired Immune Deficiency Syndrome (AIDS). EFV has low solubility in water resulting in a decrease in the dissolution rate and, consequently, in its bioavailability. Among the technological alternatives to increase solubility, the Lamellar Double Hydroxides (LDH) have been applied in the development of systems with poorly water-soluble drugs. The use of analytical techniques such as X-Ray Diffraction (XRD), Infrared Spectroscopy (IR) and Differential Scanning Calorimetry (DSC) allowed the elucidation of drug interaction with the lamellar compounds. The objective of this work was to characterize and develop the binary systems with EFV and LDH in order to increase the solubility of the drug. The LDH-CaAl was synthesized by the method of co-precipitation from salt solutions of calcium nitrate and aluminum nitrate in basic medium. The systems EFV-LDH and their physical mixtures (PM) were obtained at different concentrations (5-60% of EFV) using the solvent technique described by Takahashi & Yamaguchi (1991). The characterization of the systems and the PM’s was performed by XRD techniques, IR, DSC and dissolution test under non-sink conditions. The results showed improvements in the solubility of EFV when associated with LDH, due to a possible change in its crystal structure and formation of an amorphous material. From the DSC results, one could see that the endothermic peak at 173°C, temperature that correspond to the melting process of EFZ in the crystal form, was present in the PM results. For the EFZ-LDH systems (with 5, 10 and 30% of drug loading), this peak was not observed. XRD profiles of the PM showed well-defined peaks for EFV. Analyzing the XRD patterns of the systems, it was found that the XRD profiles of all the systems showed complete attenuation of the characteristic peaks of the crystalline form of EFZ. The IR technique showed that, in the results of the PM, there was the appearance of one band and overlap of other bands, while the IR results of the systems with 5, 10 and 30% drug loading showed the disappearance of bands and a few others with reduced intensity. The dissolution test under non-sink conditions showed that systems with 5, 10 and 30% drug loading promoted a great increase in the solubility of EFV, but the system with 10% of drug loading was the only one that could keep substantial amount of drug in solution at different pHs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Efavirenz" title="Efavirenz">Efavirenz</a>, <a href="https://publications.waset.org/abstracts/search?q=Lamellar%20Double%20Hydroxides" title=" Lamellar Double Hydroxides"> Lamellar Double Hydroxides</a>, <a href="https://publications.waset.org/abstracts/search?q=Pharmaceutical%20Techonology" title=" Pharmaceutical Techonology"> Pharmaceutical Techonology</a>, <a href="https://publications.waset.org/abstracts/search?q=Solubility" title=" Solubility"> Solubility</a> </p> <a href="https://publications.waset.org/abstracts/25692/obtainment-of-systems-with-efavirenz-and-lamellar-double-hydroxide-as-an-alternative-for-solubility-improvement-of-the-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25692.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">583</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Ma.%20Larissa%20Lelu%20P.%20Gata&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Ma.%20Larissa%20Lelu%20P.%20Gata&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div 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