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Disponível em 11 línguas" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-11" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">11 línguas</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/ADN_polimerasa_I" title="ADN polimerasa I — catalão" lang="ca" hreflang="ca" data-title="ADN polimerasa I" data-language-autonym="Català" data-language-local-name="catalão" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/DNA_polymer%C3%A1za_I" title="DNA polymeráza I — checo" lang="cs" hreflang="cs" data-title="DNA polymeráza I" data-language-autonym="Čeština" data-language-local-name="checo" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/DNA-Polymerase_I" title="DNA-Polymerase I — alemão" lang="de" hreflang="de" data-title="DNA-Polymerase I" data-language-autonym="Deutsch" data-language-local-name="alemão" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/DNA_polymerase_I" title="DNA polymerase I — inglês" lang="en" hreflang="en" data-title="DNA polymerase I" data-language-autonym="English" data-language-local-name="inglês" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/ADN_polym%C3%A9rase_I" title="ADN polymérase I — francês" lang="fr" hreflang="fr" data-title="ADN polymérase I" data-language-autonym="Français" data-language-local-name="francês" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/ADN_polimerase_I" title="ADN polimerase I — galego" lang="gl" hreflang="gl" data-title="ADN polimerase I" data-language-autonym="Galego" data-language-local-name="galego" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/DNA_polimerasi_I" title="DNA polimerasi I — italiano" lang="it" hreflang="it" data-title="DNA polimerasi I" data-language-autonym="Italiano" data-language-local-name="italiano" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/DNK_polimeraza_I" title="DNK polimeraza I — servo-croata" lang="sh" hreflang="sh" data-title="DNK polimeraza I" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="servo-croata" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/DNK_polimeraza_I" title="DNK polimeraza I — sérvio" lang="sr" hreflang="sr" data-title="DNK polimeraza I" data-language-autonym="Српски / srpski" data-language-local-name="sérvio" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%94%D0%9D%D0%9A-%D0%BF%D0%BE%D0%BB%D1%96%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0_I" title="ДНК-полімераза I — ucraniano" lang="uk" hreflang="uk" data-title="ДНК-полімераза I" data-language-autonym="Українська" data-language-local-name="ucraniano" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/DNA%E8%81%9A%E5%90%88%E9%85%B6I" title="DNA聚合酶I — chinês" lang="zh" hreflang="zh" data-title="DNA聚合酶I" data-language-autonym="中文" data-language-local-name="chinês" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q2529148#sitelinks-wikipedia" title="Editar hiperligações interlínguas" class="wbc-editpage">Editar hiperligações</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Espaços nominais"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div 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.tmbox.mbox-small{clear:right;float:right;margin:4px 0 4px 1em;width:238px}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .tmbox{background-color:#2e2505}html.skin-theme-clientpref-night .mw-parser-output .tmbox-speedy{background-color:#310402}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .tmbox{background-color:#2e2505}html.skin-theme-clientpref-os .mw-parser-output .tmbox-speedy{background-color:#310402}}body.skin--responsive .mw-parser-output table.tmbox img{max-width:none!important}</style><table class="box-Sem_notas plainlinks metadata ambox ambox-content ambox-content" role="presentation"><tbody><tr><td class="mbox-image"><div style="width:52px"><span typeof="mw:File"><a href="/wiki/Wikip%C3%A9dia:Livro_de_estilo/Cite_as_fontes" title="Wikipédia:Livro de estilo/Cite as fontes"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Text_document_with_red_question_mark.svg/40px-Text_document_with_red_question_mark.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Text_document_with_red_question_mark.svg/60px-Text_document_with_red_question_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Text_document_with_red_question_mark.svg/80px-Text_document_with_red_question_mark.svg.png 2x" data-file-width="48" data-file-height="48" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span">Este artigo ou secção contém <a href="/wiki/Wikip%C3%A9dia:Livro_de_estilo/Cite_as_fontes#Referências_no_fim" title="Wikipédia:Livro de estilo/Cite as fontes">uma lista de referências no fim do texto</a>, mas as suas fontes não são claras porque <b>não são <a href="/wiki/Wikip%C3%A9dia:Livro_de_estilo/Cite_as_fontes#Referências_no_texto" title="Wikipédia:Livro de estilo/Cite as fontes">citadas no corpo do artigo</a></b>, o que <b>compromete a <a href="/wiki/Wikip%C3%A9dia:V" class="mw-redirect" title="Wikipédia:V">confiabilidade</a></b> das informações.<span class="hide-when-compact"> Ajude a <span class="plainlinks"><a class="external text" href="https://pt.wikipedia.org/w/index.php?title=ADN_polimerase_I&action=edit">melhorar</a></span> este artigo <a href="/wiki/Wikip%C3%A9dia:Livro_de_estilo/Refer%C3%AAncias_e_notas_de_rodap%C3%A9" title="Wikipédia:Livro de estilo/Referências e notas de rodapé">inserindo citações no corpo do artigo</a>.</span> <small class="date-container"><i>(<span class="date">Novembro de 2020</span>)</i></small></div></td></tr></tbody></table> <table class="infobox infobox_v2" cellpadding="3" border="0" style="width: 20em; text-align: left; font-size: 88%;"> <tbody><tr> <th colspan="2" class="topo padrao" style="background-color:transparent;"><span class="">DNA polimerase I</span> </th></tr> <tr> <td colspan="2" style="text-align:center;"><div style="padding-bottom: 5px;"><figure class="mw-halign-center" typeof="mw:File"><a href="/wiki/Ficheiro:PolymeraseDomains.jpg" class="mw-file-description" title="ADN polimerase I"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/31/PolymeraseDomains.jpg/220px-PolymeraseDomains.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/31/PolymeraseDomains.jpg/330px-PolymeraseDomains.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/31/PolymeraseDomains.jpg/440px-PolymeraseDomains.jpg 2x" data-file-width="900" data-file-height="600" /></a><figcaption>ADN polimerase I</figcaption></figure></div>Domínios funcionais no fragmento de Klenow (esquerda) e na DNA polimerase I (direita). </td></tr> <tr> <th colspan="2" style="text-align:center; background-color:#ddd;">Indicadores </th></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/N%C3%BAmero_EC" title="Número EC">Número EC</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/7/7/7.html">2.7.7.7</a> </td></tr> <tr> <th colspan="2" style="text-align:center; background-color:#ddd;">Bases de dados </th></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=2.7.7.7">IntEnz</a> </td></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.7.7.7">BRENDA</a> </td></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/ExPASy" title="ExPASy">ExPASy</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://www.expasy.org/enzyme/2.7.7.7">NiceZyme</a> </td></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/KEGG" title="KEGG">KEGG</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://www.genome.ad.jp/dbget-bin/www_bget?enzyme+2.7.7.7">KEGG</a> </td></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://biocyc.org/META/substring-search?type=NIL&object=2.7.7.7">via metabólica</a> </td></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;"><a href="/wiki/PRIAM" title="PRIAM">PRIAM</a> </td> <td style="vertical-align: top; text-align: left;"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=2.7.7.7">PRIAM</a> </td></tr> <tr> <td scope="row" style="vertical-align: top; text-align: left; background-color:transparent;">Estruturas <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> </td> <td style="vertical-align: top; text-align: left;"><small><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:2.7.7.7">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:2.7.7.7">PDBe</a> <a rel="nofollow" class="external text" href="https://pdbj.org/mine/sql?query=SELECT+DISTINCT+pdbid+FROM+entity+WHERE+entity.pdbx_ec%3D%272.7.7.7%27">PDBj</a> <a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.7.7.7">PDBsum</a></small> </td></tr> <tr> <td style="vertical-align: top; text-align: center;" colspan="2"><table class="collapsible collapsed" style="border: none; padding: 0; margin: 0; width: 100%; text-align: left"> <tbody><tr style="background-color: #ddd; text-align: center"> <th colspan="2">Pesquisa</th> </tr> <tr> <th style="background-color: #eee; width:80px"> <p><a href="/wiki/PubMed_Central" title="PubMed Central">PubMed Central</a> </p> </th> <td style="background-color: transparent"> <p><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=2.7.7.7%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">artigos</a> </p> </td> </tr> <tr> <th style="background-color: #eee; width:120px"> <p><a href="/wiki/PubMed" title="PubMed">PubMed</a> </p> </th> <td style="background-color: transparent"> <p><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=2.7.7.7%5BEC/RN%20Number%5D">artigos</a> </p> </td> </tr> </tbody></table> </td></tr> </tbody></table> <p><br /> A <b>DNA polimerase I</b> (ou <b>Pol I</b>) é uma <a href="/wiki/Enzima" title="Enzima">enzima</a> relacionada ao reparo do DNA, codificada pelo gene polA, altamente ativa em Escherichia coli, possui atividade <a href="/w/index.php?title=Exonuclease&action=edit&redlink=1" class="new" title="Exonuclease (página não existe)">exonuclease</a> tanto 5'-3' quanto 3'-5'. Além disso, começa o processo de elongamento do DNA após a primase na origem de replicação(ORI) 5'-3'. Contudo, sua baixa processividade é preterida pela alta velocidade da DNA polimerase III, que assume o papel principal da replicação do DNA em E. Coli aproximadamente 400 pares de base a jusante da origem. Além disso, possui um papel no processamento dos <a href="/wiki/Fragmentos_de_Okazaki" class="mw-redirect" title="Fragmentos de Okazaki">fragmentos de Okazaki</a>. </p><p>Há artigos na literatura que sugerem que a DNA polimerase I possua atividade de transcriptase reversa, tendo sua utilidade como tal em processos específicos, como a formação de repetições palindrômicas, além de ser uma possível “remanescente de enzimas ancestrais envolvidas tanto em replicação dependente de DNA e replicação dependente de DNA”. A Pol I é formada por uma única subunidade, uma única cadeia polipeptídica, que quando quebrada enzimaticamente de forma controlada libera sua subunidade catalítica, chamada de Fragmento Klenow. </p> <table class="noprint" style="border-top:none; border-bottom:none; background:transparent; color: inherit"><tbody><tr> <td style="text-align: center;"><span typeof="mw:File"><a href="/wiki/Ficheiro:Neuraminidase_Ribbon_Diagram.jpg" class="mw-file-description"><img alt="Ícone de esboço" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/27/Neuraminidase_Ribbon_Diagram.jpg/18px-Neuraminidase_Ribbon_Diagram.jpg" decoding="async" width="18" height="23" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/27/Neuraminidase_Ribbon_Diagram.jpg/27px-Neuraminidase_Ribbon_Diagram.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/27/Neuraminidase_Ribbon_Diagram.jpg/36px-Neuraminidase_Ribbon_Diagram.jpg 2x" data-file-width="810" data-file-height="1024" /></a></span></td> <td><i>Este artigo sobre <a href="/wiki/Enzima" title="Enzima">enzimas</a> é um <a href="/wiki/Wikip%C3%A9dia:Esbo%C3%A7o" title="Wikipédia:Esboço">esboço</a>. Você pode ajudar a Wikipédia <b><span class="plainlinks"><a class="external text" href="https://pt.wikipedia.org/w/index.php?title=ADN_polimerase_I&action=edit">expandindo-o</a></span></b>.</i><div class="plainlinks hlist navbar mini" style="position:absolute; right:15px; font-size:smaller; display:none;"><ul><li class="nv-ver"><a href="/wiki/Predefini%C3%A7%C3%A3o:Esbo%C3%A7o-enzima" title="Predefinição:Esboço-enzima"><abbr title="Ver esta predefinição">v</abbr></a></li><li class="nv-discutir"><a href="/w/index.php?title=Predefini%C3%A7%C3%A3o_Discuss%C3%A3o:Esbo%C3%A7o-enzima&action=edit&redlink=1" class="new" title="Predefinição Discussão:Esboço-enzima (página não existe)"><abbr title="Discutir esta predefinição">d</abbr></a></li><li class="nv-editar"><a class="external text" href="https://pt.wikipedia.org/w/index.php?title=Predefini%C3%A7%C3%A3o:Esbo%C3%A7o-enzima&action=edit"><abbr title="Editar esta predefinição">e</abbr></a></li></ul></div></td> </tr></tbody></table> <p>trissomia do 18. </p><p><br /> </p><p><br /> </p><p><br /> </p><p>trissomia do 18. Referencias: </p><p>Structure and mechanism of DNA polymerases.trissomia do 18. Encontrado em:<a rel="nofollow" class="external free" href="https://web.archive.org/web/20130217013013/http://www-lehre.img.bio.uni-goettingen.de/Vorlesung_SS_2007/Kramer/pdf/Rothwell_Waksman_2005_review_Structure_mechanism_DNA_Polymerase_Adv_Prot_Chem_71_401.pdf">https://web.archive.org/web/20130217013013/http://www-lehre.img.bio.uni-goettingen.de/Vorlesung_SS_2007/Kramer/pdf/Rothwell_Waksman_2005_review_Structure_mechanism_DNA_Polymerase_Adv_Prot_Chem_71_401.pdf</a> (Acesso em 10/06/2012) </p><p>E.coli DNA polymerase I as a reverse transcriptase Encontrado em: <a rel="nofollow" class="external free" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC413221/pdf/emboj00074-0027.pdf">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC413221/pdf/emboj00074-0027.pdf</a> (Acesso em 09/06/2014) </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Obtida de "<a dir="ltr" href="https://pt.wikipedia.org/w/index.php?title=ADN_polimerase_I&oldid=59901485">https://pt.wikipedia.org/w/index.php?title=ADN_polimerase_I&oldid=59901485</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Especial:Categorias" title="Especial:Categorias">Categorias</a>: <ul><li><a href="/wiki/Categoria:EC_2.7" title="Categoria:EC 2.7">EC 2.7</a></li><li><a href="/wiki/Categoria:Replica%C3%A7%C3%A3o_de_DNA" title="Categoria:Replicação de DNA">Replicação de DNA</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Categorias ocultas: <ul><li><a href="/wiki/Categoria:!Artigos_que_carecem_de_notas_de_rodap%C3%A9_desde_novembro_de_2020" title="Categoria:!Artigos que carecem de notas de rodapé desde novembro de 2020">!Artigos que carecem de notas de rodapé desde novembro de 2020</a></li><li><a href="/wiki/Categoria:!Artigos_que_carecem_de_notas_de_rodap%C3%A9_sem_indica%C3%A7%C3%A3o_de_tema" title="Categoria:!Artigos que carecem de notas de rodapé sem indicação de tema">!Artigos que carecem de notas de rodapé sem indicação de tema</a></li><li><a href="/wiki/Categoria:!Esbo%C3%A7os_sobre_enzimas" title="Categoria:!Esboços sobre enzimas">!Esboços sobre enzimas</a></li><li><a href="/wiki/Categoria:!Esbo%C3%A7os_maiores_que_1000_bytes" title="Categoria:!Esboços maiores que 1000 bytes">!Esboços maiores que 1000 bytes</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Esta página foi editada pela última vez às 13h29min de 29 de novembro de 2020.</li> <li id="footer-info-copyright">Este texto é disponibilizado nos termos da licença <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.pt">Atribuição-CompartilhaIgual 4.0 Internacional (CC BY-SA 4.0) da Creative Commons</a>; pode estar sujeito a condições adicionais. 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