Hippocampus Proteomic of Major Depression and Antidepressant Treatment: Involvement of Cell Proliferation, Differentiation, and Connectivity

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Depression and Antidepressant Treatment: Involvement of Cell Proliferation, Differentiation, and Connectivity</title> <meta name="description" content="Hippocampus Proteomic of Major Depression and Antidepressant Treatment: Involvement of Cell Proliferation, Differentiation, and Connectivity"> <meta name="keywords" content="proteomics, hippocampus, depression, mitosis, migration, differentiation, mitochondria, apoptosis, antidepressants, human brain"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> 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<div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 87351</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Hippocampus Proteomic of Major Depression and Antidepressant Treatment: Involvement of Cell Proliferation, Differentiation, and Connectivity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dhruv%20J.%20Limaye">Dhruv J. Limaye</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanga%20Galfalvy"> Hanga Galfalvy</a>, <a href="https://publications.waset.org/abstracts/search?q=Cheick%20A.%20Sissoko"> Cheick A. Sissoko</a>, <a href="https://publications.waset.org/abstracts/search?q=Yung-yu%20Huang"> Yung-yu Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chunanning%20Tang"> Chunanning Tang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ying%20Liu"> Ying Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Shu-Chi%20Hsiung"> Shu-Chi Hsiung</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrew%20J.%20Dwork"> Andrew J. Dwork</a>, <a href="https://publications.waset.org/abstracts/search?q=Gorazd%20B.%20Rosoklija"> Gorazd B. Rosoklija</a>, <a href="https://publications.waset.org/abstracts/search?q=Victoria%20Arango"> Victoria Arango</a>, <a href="https://publications.waset.org/abstracts/search?q=Lewis%20Brown"> Lewis Brown</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20John%20Mann"> J. John Mann</a>, <a href="https://publications.waset.org/abstracts/search?q=Maura%20Boldrini"> Maura Boldrini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Memory and emotion require hippocampal cell viability and connectivity and are disrupted in major depressive disorder (MDD). Applying shotgun proteomics and stereological quantification of neural progenitor cells (NPCs), intermediate neural progenitors (INPs), and mature granule neurons (GNs), to postmortem human hippocampus, identified differentially expressed proteins (DEPs), and fewer NPCs, INPs and GNs, in untreated MDD (uMDD) compared with non-psychiatric controls (CTRL) and antidepressant-treated MDD (MDDT). DEPs lower in uMDD vs. CTRL promote mitosis, differentiation, and prevent apoptosis. DEPs higher in uMDD vs. CTRL inhibit the cell cycle, and regulate cell adhesion, neurite outgrowth, and DNA repair. DEPs lower in MDDT vs. uMDD block cell proliferation. We observe group-specific correlations between numbers of NPCs, INPs, and GNs and an abundance of proteins regulating mitosis, differentiation, and apoptosis. Altered protein expression underlies hippocampus cellular and volume loss in uMDD, supports a trophic effect of antidepressants, and offers new treatment targets. <iframe src="https://publications.waset.org/abstracts/160934.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=proteomics" title="proteomics">proteomics</a>, <a href="https://publications.waset.org/abstracts/search?q=hippocampus" title=" hippocampus"> hippocampus</a>, <a href="https://publications.waset.org/abstracts/search?q=depression" title=" depression"> depression</a>, <a href="https://publications.waset.org/abstracts/search?q=mitosis" title=" mitosis"> mitosis</a>, <a href="https://publications.waset.org/abstracts/search?q=migration" title=" migration"> migration</a>, <a href="https://publications.waset.org/abstracts/search?q=differentiation" title=" differentiation"> differentiation</a>, <a href="https://publications.waset.org/abstracts/search?q=mitochondria" title=" mitochondria"> mitochondria</a>, <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title=" apoptosis"> apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=antidepressants" title=" antidepressants"> antidepressants</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20brain" title=" human brain"> human brain</a> </p> <a href="https://publications.waset.org/abstracts/160934/hippocampus-proteomic-of-major-depression-and-antidepressant-treatment-involvement-of-cell-proliferation-differentiation-and-connectivity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/160934.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" 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Hippocampus Proteomic of Major Depression and Antidepressant Treatment: Involvement of Cell Proliferation, Differentiation, and Connectivity