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QSAR and Anti-Depressant Studies of Some Novel Phenothiazine Derivatives
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class="card-body"><strong>Paper Count:</strong> 87354</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">QSAR and Anti-Depressant Studies of Some Novel Phenothiazine Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20L.%20Tambe">D. L. Tambe</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Dighe%20Nachiket"> S. Dighe Nachiket</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: Depression is a common but serious illness and the phenothiazine derivatives shows prominent effect against the depression hence work was undertaken to validate this use scientifically. Material and Methods: Synthesis of phenothiazine derivatives are done by the substitution of various groups, but the basic scheme of synthesis is started with synthesis of 4-(Cyclohexylidene) Benzoic acid using PABA. After that with the further six step of synthesis of 3-(10H-phenothiazin-2-yl)-N, 5-diphenyl-4H-1, 2, 4-triazol-4-amine is done which is final product. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug imipramine was used as the control. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Results: Among the all phenothiazine derivatives four compounds (6.6-7.2 (14H –phenyl ), 9.43 (1H OH), 8.50 (1H NH phenothiazine),6.85-8.21(14H phenyl), 8.50 (1H NH phenothiazine), 11.82 (1H – OH), 6.6-7.2 (8H –phenyl ), 9.43 (1H OH), 8.50 (1H NH phenothiazine), 4.2 (1H NH) and 6.85-8.21(8H phenyl), 8.50 (1H NH phenothiazine), 3.9 (1H NH) 11.82 (1H – OH) showed significant antidepressant activity comparing with control drug imipramine. Conclusion: Various Novel phenothiazine derivatives show more potent antidepressant activity and it plays more beneficial role in human health for the treatment of depression. <iframe src="https://publications.waset.org/abstracts/26552.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antidepressant%20activities" title="antidepressant activities">antidepressant activities</a>, <a href="https://publications.waset.org/abstracts/search?q=despair%20swim%20test" title=" despair swim test"> despair swim test</a>, <a href="https://publications.waset.org/abstracts/search?q=phenothiazine" title=" phenothiazine"> phenothiazine</a>, <a href="https://publications.waset.org/abstracts/search?q=Sprague%20Dawley%20Rats" title=" Sprague Dawley Rats"> Sprague Dawley Rats</a> </p> <a 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