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href="https://jax.academia.edu/GeorgeSutphin"><img class="profile-avatar u-positionAbsolute" alt="George Sutphin" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/39353990/10849101/12108207/s200_george.sutphin.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://jax.academia.edu/GeorgeSutphin">George Sutphin</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">The Jackson Laboratory</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://rteu.academia.edu/serkangul"><img class="profile-avatar u-positionAbsolute" alt="serkan gul" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/40352851/11022882/12300968/s200_serkan.gul.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://rteu.academia.edu/serkangul">serkan gul</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Recep Tayyip Erdogan University</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42009732" href="https://www.academia.edu/Documents/in/Mountaineering"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/ChristineParks","location":"/ChristineParks","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/ChristineParks","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Mountaineering"]}" data-trace="false" data-dom-id="Pill-react-component-979af8bc-9290-4962-8739-0aca9cce760a"></div> <div id="Pill-react-component-979af8bc-9290-4962-8739-0aca9cce760a"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42009732" href="https://www.academia.edu/Documents/in/Muscle_Physiology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Muscle Physiology"]}" data-trace="false" data-dom-id="Pill-react-component-40bb4361-ab8a-47f1-b20d-84111b8c111a"></div> <div id="Pill-react-component-40bb4361-ab8a-47f1-b20d-84111b8c111a"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42009732" href="https://www.academia.edu/Documents/in/Systemic_Lupus_Erythematosus"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Systemic Lupus Erythematosus"]}" data-trace="false" data-dom-id="Pill-react-component-27add229-f0c9-4119-ad36-12b9c5373c69"></div> <div id="Pill-react-component-27add229-f0c9-4119-ad36-12b9c5373c69"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42009732" href="https://www.academia.edu/Documents/in/Triathlon"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Triathlon"]}" data-trace="false" data-dom-id="Pill-react-component-e0bda880-4fd7-434a-9760-c77d877ddb49"></div> <div id="Pill-react-component-e0bda880-4fd7-434a-9760-c77d877ddb49"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42009732" href="https://www.academia.edu/Documents/in/Altitude"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Altitude"]}" data-trace="false" data-dom-id="Pill-react-component-5c2361ec-5670-4c52-9ea5-6d0659eb1273"></div> <div id="Pill-react-component-5c2361ec-5670-4c52-9ea5-6d0659eb1273"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Christine Parks</h3></div><div class="js-work-strip profile--work_container" data-work-id="124006085"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006085/Racial_Ethnic_Differences_in_Associations_Between_Traumatic_Childhood_Experiences_and_Both_Metabolic_Syndrome_Prevalence_and_Type_2_Diabetes_Risk_Among_a_Cohort_of_U_S_Women"><img alt="Research paper thumbnail of Racial/Ethnic Differences in Associations Between Traumatic Childhood Experiences and Both Metabolic Syndrome Prevalence and Type 2 Diabetes Risk Among a Cohort of U.S. Women" class="work-thumbnail" src="https://attachments.academia-assets.com/118312111/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006085/Racial_Ethnic_Differences_in_Associations_Between_Traumatic_Childhood_Experiences_and_Both_Metabolic_Syndrome_Prevalence_and_Type_2_Diabetes_Risk_Among_a_Cohort_of_U_S_Women">Racial/Ethnic Differences in Associations Between Traumatic Childhood Experiences and Both Metabolic Syndrome Prevalence and Type 2 Diabetes Risk Among a Cohort of U.S. Women</a></div><div class="wp-workCard_item"><span>Diabetes Care</span><span>, Dec 16, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2d265dfa347571fa69bfcd988fdf498" class="wp-workCard--action" rel="nofollow" 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window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006085]").text(description); $(".js-view-count[data-work-id=124006085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d2d265dfa347571fa69bfcd988fdf498" } } $('.js-work-strip[data-work-id=124006085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006085,"title":"Racial/Ethnic Differences in Associations Between Traumatic Childhood Experiences and Both Metabolic Syndrome Prevalence and Type 2 Diabetes Risk Among a Cohort of U.S. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006084/Pesticide_use_and_incident_hyperthyroidism_in_farmers_in_the_Agricultural_Health_Study"><img alt="Research paper thumbnail of Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study" class="work-thumbnail" src="https://attachments.academia-assets.com/118312110/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006084/Pesticide_use_and_incident_hyperthyroidism_in_farmers_in_the_Agricultural_Health_Study">Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span><span>, Feb 25, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Few studies have evaluated associations between pesticides and hyperthyroidism. Objec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Few studies have evaluated associations between pesticides and hyperthyroidism. Objective: We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study (AHS). Methods: We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals (CI) for associations between pesticide use at enrollment and hyperthyroidism (n=271) in 35,150 applicators (mostly men), adjusting for potential confounders. Results: Ever-use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤ 62 years) was associated with reduced hyperthyroidism risk, with hazard ratios ranging from 0.50 (95% CI: 0.30-0.83) for maneb/mancozeb to 0.77 (95% CI: 0.59-1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensityweighted lifetime days of using carbofuran and chlorpyrifos (p-trend ≤ 0.05).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dea66e5a29432f995a06dfa989e16984" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312110,"asset_id":124006084,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312110/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006084; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006084]").text(description); $(".js-view-count[data-work-id=124006084]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006084; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006084']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006083"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006083/Coffee_and_Tea_Consumption_in_Relation_to_Risk_of_Rheumatoid_Arthritis_in_the_Women%CA%BCs_Health_Initiative_Observational_Cohort"><img alt="Research paper thumbnail of Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Womenʼs Health Initiative Observational Cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/118312109/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006083/Coffee_and_Tea_Consumption_in_Relation_to_Risk_of_Rheumatoid_Arthritis_in_the_Women%CA%BCs_Health_Initiative_Observational_Cohort">Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Womenʼs Health Initiative Observational Cohort</a></div><div class="wp-workCard_item"><span>Jcr-journal of Clinical Rheumatology</span><span>, Apr 1, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives-To evaluate whether tea or coffee consumption is associated with an increased risk of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives-To evaluate whether tea or coffee consumption is associated with an increased risk of older-onset rheumatoid arthritis (RA) using the Women's Health Initiative Observational Study (WHI-OS). Methods-WHI-OS is a longitudinal prospective cohort study conducted from 1993 to 1998. 76,853 women completed a self-administered questionnaire about their daily consumption of tea and coffee. 185 self-reported and validated incident cases of RA were observed after three years of observation. Multivariable Cox proportional hazard models were performed to assess the relationship between consumption habits and disease incidence. Trend tests were calculated using categorical variables modeled as a continuous variable without collapsing. Results-There was no increase in the hazard ratio (HR) for incident RA in those participants who drank coffee compared to those who did not. The amount of coffee consumed and the method of preparation (caffeinated/decaffeinated; filtered/unfiltered) also did not alter the risk of incident RA. There was a positive association of incident RA and caffeinated tea consumption in the trend test (p=0.03). When assessing any caffeinated tea consumption versus no tea consumption, the HR for incident RA was 1.40 (CI 1.01-1.93, p=0.04).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f0b39cb194b9cf1ca20946716e27965a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312109,"asset_id":124006083,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312109/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006083"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006083"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006083; 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006080"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006080/Metagenomics_reveals_novel_microbial_signatures_of_farm_exposures_in_house_dust"><img alt="Research paper thumbnail of Metagenomics reveals novel microbial signatures of farm exposures in house dust" class="work-thumbnail" src="https://attachments.academia-assets.com/118312126/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006080/Metagenomics_reveals_novel_microbial_signatures_of_farm_exposures_in_house_dust">Metagenomics reveals novel microbial signatures of farm exposures in house dust</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Indoor home dust microbial communities, important contributors to human health outcomes, are shap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Indoor home dust microbial communities, important contributors to human health outcomes, are shaped by environmental factors, including farm-related exposures. Detection and characterization of microbiota are influenced by sequencing methodology; however, it is unknown if advanced metagenomic whole genome shotgun sequencing (WGS) can detect novel associations between environmental exposures and the indoor built-environment dust microbiome, compared to conventional 16S rRNA amplicon sequencing (16S). This study aimed to better depict indoor dust microbial communities using WGS to investigate novel associations with environmental risk factors from the homes of 781 farmers and farm spouses enrolled in the Agricultural Lung Health Study. We examined various farm-related exposures, including living on a farm, crop versus animal production, and type of animal production, as well as non-farm exposures, including home cleanliness and indoor pets. 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006077/The_impact_of_farm_animal_exposures_on_Campylobacter_jejuni_antibody_levels_in_rural_agricultural_communities_of_Iowa_USA"><img alt="Research paper thumbnail of The impact of farm animal exposures on Campylobacter jejuni antibody levels in rural agricultural communities of Iowa, USA" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006077/The_impact_of_farm_animal_exposures_on_Campylobacter_jejuni_antibody_levels_in_rural_agricultural_communities_of_Iowa_USA">The impact of farm animal exposures on Campylobacter jejuni antibody levels in rural agricultural communities of Iowa, USA</a></div><div class="wp-workCard_item"><span>ISEE Conference Abstracts</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006077]").text(description); $(".js-view-count[data-work-id=124006077]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006077']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006076"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006076/Residential_Wood_Burning_and_Pulmonary_Function_in_the_Agricultural_Lung_Health_Study"><img alt="Research paper thumbnail of Residential Wood Burning and Pulmonary Function in the Agricultural Lung Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006076/Residential_Wood_Burning_and_Pulmonary_Function_in_the_Agricultural_Lung_Health_Study">Residential Wood Burning and Pulmonary Function in the Agricultural Lung Health Study</a></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006076"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006076"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006076; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006076]").text(description); $(".js-view-count[data-work-id=124006076]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006076; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006076']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006076]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006076,"title":"Residential Wood Burning and Pulmonary Function in the Agricultural Lung Health Study","internal_url":"https://www.academia.edu/124006076/Residential_Wood_Burning_and_Pulmonary_Function_in_the_Agricultural_Lung_Health_Study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006075"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006075/Use_of_permethrin_and_other_pyrethroids_and_mortality_in_the_Agricultural_Health_Study"><img alt="Research paper thumbnail of Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006075/Use_of_permethrin_and_other_pyrethroids_and_mortality_in_the_Agricultural_Health_Study">Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesPyrethroid insecticides have been linked with multiple health outcomes. One study repor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesPyrethroid insecticides have been linked with multiple health outcomes. One study reported an association with increased all-cause and cardiovascular mortality. Given the widespread use of pyrethroids, these findings warrant confirmation. We explored associations of permethrin/pyrethroid use with overall and cause-specific mortality among 50 665 licensed pesticide applicators in the Agricultural Health Study.MethodsAt enrolment (1993–1997), participants self-reported information on permethrin/pyrethroid use. Information on causes of death came from linkage with death registries through 2016. We used Cox proportional hazards models to estimate HRs and 95% CIs with adjustment for potential confounders.ResultsOver an average 21 years of follow-up, 19.6% (9,955) of the cohort died. We found no clear evidence that ever-use of permethrin/pyrethroid was associated with elevated overall mortality or with mortality from most causes examined. There was suggestive evidence, based on ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006075"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006075]").text(description); $(".js-view-count[data-work-id=124006075]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006075']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006075]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006075,"title":"Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study","internal_url":"https://www.academia.edu/124006075/Use_of_permethrin_and_other_pyrethroids_and_mortality_in_the_Agricultural_Health_Study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006074"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006074/Completeness_of_cohort_linked_U_S_Medicare_data_An_example_from_the_Agricultural_Health_Study_1999_2016_"><img alt="Research paper thumbnail of Completeness of cohort-linked U.S. Medicare data: An example from the Agricultural Health Study (1999–2016)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006074/Completeness_of_cohort_linked_U_S_Medicare_data_An_example_from_the_Agricultural_Health_Study_1999_2016_">Completeness of cohort-linked U.S. Medicare data: An example from the Agricultural Health Study (1999–2016)</a></div><div class="wp-workCard_item"><span>Preventive Medicine Reports</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highlights • We describe linked U.S. Medicare claims data in the Agricultural Health Study.• Inco...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highlights • We describe linked U.S. Medicare claims data in the Agricultural Health Study.• Incomplete claims data were related to geographic, demographic, and health.• We saw potential informative missingness by pesticide use and mortality.• Incomplete data in Medicare-linked cohorts may impact sample size and validity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006074"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006074"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006074; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006074]").text(description); $(".js-view-count[data-work-id=124006074]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006074; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006074']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006074]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006074,"title":"Completeness of cohort-linked U.S. Medicare data: An example from the Agricultural Health Study (1999–2016)","internal_url":"https://www.academia.edu/124006074/Completeness_of_cohort_linked_U_S_Medicare_data_An_example_from_the_Agricultural_Health_Study_1999_2016_","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006073"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006073/Agricultural_Pesticides_and_Shingles_Risk_in_a_Prospective_Cohort_of_Licensed_Pesticide_Applicators"><img alt="Research paper thumbnail of Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006073/Agricultural_Pesticides_and_Shingles_Risk_in_a_Prospective_Cohort_of_Licensed_Pesticide_Applicators">Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators</a></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Some pesticides are immunotoxic and have been associated with an increased risk of im...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Some pesticides are immunotoxic and have been associated with an increased risk of immune-mediated diseases. The risk of shingles, the clinical reactivation of varicella-zoster virus, increases with aging and immunosuppression; little is known about its associations with pesticides. Objective: We examined the use of agricultural pesticides in relation to incident shingles in a prospective cohort of licensed pesticide applicators. Methods: The study sample included 12,820 (97% male) farmers (enrolled in 1993–1997 in North Carolina and Iowa), who were followed for a median of 12 y (interquartile range: 11–13). Shingles was self-reported at enrollment and at follow-up. We evaluated ever-use of 48 agricultural pesticides reported at study enrollment in relation to shingles risk and considered exposure–response for intensity-weighted lifetime days (IWLDs) of use. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard models, adjusting for state, and allowing estimates to vary by median attained age (60 y). Results: Incident shingles was reported by 590 participants. Associations were positive (HRs&gt;1.2) for ever- vs. never-use of eight insecticides, three fumigants, two fungicides, and five herbicides, and exposure–response trends were seen across increasing quartiles (Q3 and Q4&gt;Q1) or tertiles (T3 and T2&gt;T1) of IWLDs for four insecticides [permethrin (crops), coumaphos, malathion, and lindane], two fumigants (carbon tetrachloride/carbon disulfide and methyl bromide), and three herbicides [alachlor, trifluralin (&lt;60 years of age) and 2,4-dichlorophenoxyacetic acid]. Shingles was not associated with total years or days per year mixed or applied any pesticides, but in older participants, shingles was associated with a history of a high pesticide exposure event [HR=1.89 (95% CI: 1.45, 2.45)]. Conclusions: Several specific pesticides were associated with increased risk of shingles in farmers, especially at higher levels of cumulative use. These novel findings, if replicated in other populations, could have broader implications for the potential effects of pesticides on vaccine efficacy and susceptibility to other infections. <a href="https://doi.org/10.1289/EHP7797" rel="nofollow">https://doi.org/10.1289/EHP7797</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006073"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006073"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006073; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006070"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006070/Pesticide_use_and_kidney_function_among_farmers_in_the_Biomarkers_of_Exposure_and_Effect_in_Agriculture_study"><img alt="Research paper thumbnail of Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006070/Pesticide_use_and_kidney_function_among_farmers_in_the_Biomarkers_of_Exposure_and_Effect_in_Agriculture_study">Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study</a></div><div class="wp-workCard_item"><span>Environmental Research</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Pesticides have been reported to be associated with malignant and non-malignant kidney...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Pesticides have been reported to be associated with malignant and non-malignant kidney disease. Few studies have examined the relationship between individual pesticides and kidney dysfunction. OBJECTIVE We evaluated the associations of pesticide use with measured kidney function among male pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study, a subcohort in the Agricultural Health Study. METHODS Serum creatinine was measured in 1,545 BEEA participants and estimated glomerular filtration rate (eGFR) was calculated with the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. Using reported information on lifetime use of 41 pesticides, multivariable linear and logistic regression was used to examine associations with eGFR modeled continuously and with CKD (eGFR &lt;60 mL/min/1.73 m2), respectively. Models were adjusted for possible confounding factors related to kidney function and correlated pesticides. RESULTS Lower eGFR was observed among pesticide applicators who ever used the herbicides pendimethalin (-3.7%, 95% confidence interval (CI): -5.8%, -1.5%), atrazine (-3.7%, 95% CI: -6.9%, -0.4%), and dicamba (-2.8%, 95% CI: -5.3%, -0.2%) compared with never users of each pesticide. Ever use of pendimethalin (odds ratio (OR)=1.6, 95% CI: 1.1, 2.2) and atrazine (OR=1.8, 95% CI: 1.0, 3.0) was also associated with elevated odds of CKD, with an exposure-response association between intensity-weighted lifetime days of pendimethalin use and CKD among active farmers (N=1,302; ptrend=0.04). Atrazine use within the last year was associated with lower eGFR and elevated odds of CKD when compared with never users, and we observed exposure-response associations with intensity-weighted lifetime days among recent users. Use of several other pesticides was associated with higher eGFR. DISCUSSION These results suggest that two widely used herbicides, pendimethalin and atrazine, may be associated with altered kidney function among pesticide applicators. Our findings for these herbicides are consistent with observed associations with end-stage renal disease in the Agricultural Health Study.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006070"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006070"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006070; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006070]").text(description); $(".js-view-count[data-work-id=124006070]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006070; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006070']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006070]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006070,"title":"Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study","internal_url":"https://www.academia.edu/124006070/Pesticide_use_and_kidney_function_among_farmers_in_the_Biomarkers_of_Exposure_and_Effect_in_Agriculture_study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006069"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006069/Exposure_to_pesticides_and_oxidative_stress_in_Brazilian_agricultural_communities"><img alt="Research paper thumbnail of Exposure to pesticides and oxidative stress in Brazilian agricultural communities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006069/Exposure_to_pesticides_and_oxidative_stress_in_Brazilian_agricultural_communities">Exposure to pesticides and oxidative stress in Brazilian agricultural communities</a></div><div class="wp-workCard_item"><span>Biomarkers</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Background Oxidative stress may be an important mechanism linking pesticide exposure to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Background Oxidative stress may be an important mechanism linking pesticide exposure to several diseases. We evaluated the association between pesticide exposures and oxidative stress biomarkers in Brazilian agricultural workers. Methods A cross-sectional study was conducted in healthy agricultural (N = 52) and non-agricultural workers (N = 68) in a rural community in Rio de Janeiro State, Brazil. Regular pesticide use, sociodemographic, and lifestyle information was obtained by questionnaire. Oxidative stress biomarkers (N = 7) were measured in serum and plasma. We calculated percent differences and 95% confidence intervals (CI) in oxidative stress biomarkers for use of pesticides adjusted for sex, age, education, smoking, and alcohol consumption, using multiple linear regression. Results Living close to or in the fields was associated with glutathione peroxidase activity but not with any other markers. We observed significant positive associations between 8-isoprostane levels and activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase with reported use of certain insecticides, fungicides, and herbicides. Our results also indicate a significant and negative association between glutathione-S-transferase activity and insecticide use. Conclusions These findings suggest that use of pesticides may be associated with differences in oxidative stress biomarkers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006069"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006069]").text(description); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006069]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006069,"title":"Exposure to pesticides and oxidative stress in Brazilian agricultural communities","internal_url":"https://www.academia.edu/124006069/Exposure_to_pesticides_and_oxidative_stress_in_Brazilian_agricultural_communities","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006068"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006068/Lifetime_Pesticide_Use_and_Monoclonal_Gammopathy_of_Undetermined_Significance_in_a_Prospective_Cohort_of_Male_Farmers"><img alt="Research paper thumbnail of Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006068/Lifetime_Pesticide_Use_and_Monoclonal_Gammopathy_of_Undetermined_Significance_in_a_Prospective_Cohort_of_Male_Farmers">Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers</a></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Farmers have a higher incidence of multiple myeloma, and there is suggestive evidence...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Farmers have a higher incidence of multiple myeloma, and there is suggestive evidence of an elevated prevalence of its precursor, monoclonal gammopathy of undetermined significance (MGUS), relative to the general population. Pesticide exposures are suspected to play a role; however, the biologic plausibility for associations with multiple myeloma remains unclear. Objectives: Our objectives were to examine the prevalence of MGUS and evaluate associations with a wide range of pesticides in a large sample of farmers. Methods: We obtained sera and assessed MGUS among 1,638 male farmers ≥50 years of age in the Agricultural Health Study (AHS), a prospective cohort in Iowa and North Carolina. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed to estimate associations with MGUS for recent use (within the 12 months before phlebotomy) and cumulative intensity-weighted lifetime days of use of specific pesticides. Results: The age-standardized MGUS prevalence was significantly elevated among AHS farmers (7.7%) compared with demographically similar men in the National Health and Nutrition Examination Survey (2.8%) or Olmsted County, Minnesota (3.8%; p&lt;0.001). Recent use of permethrin was associated with MGUS [recent use vs. no recent use, OR=1.82 (95% CI: 1.06, 3.13)], especially among those who had also used it in the past [recent and past use vs. never use, OR=2.49 (95% CI: 1.32, 4.69)]. High intensity-weighted lifetime use of the organochlorine insecticides aldrin and dieldrin was associated with MGUS relative to those who never used either of these pesticides [OR=2.42 (95% CI: 1.29, 4.54); ptrend=0.006]. We also observed a positive association with high lifetime use of petroleum oil/distillates as an herbicide, as well as an inverse association with fonofos use. Discussion: This is the largest investigation of MGUS in farmers and the first to identify an association with MGUS for permethrin, a pyrethroid insecticide previously associated with multiple myeloma. Given the continued widespread use of permethrin in various residential and commercial settings, our findings may have important implications for exposed individuals in the general population. <a href="https://doi.org/10.1289/EHP6960" rel="nofollow">https://doi.org/10.1289/EHP6960</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006068"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006068"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006068; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006067"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006067/House_dust_microbiota_in_relation_to_adult_asthma_and_atopy_in_a_US_farming_population"><img alt="Research paper thumbnail of House dust microbiota in relation to adult asthma and atopy in a US farming population" class="work-thumbnail" src="https://attachments.academia-assets.com/118312125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006067/House_dust_microbiota_in_relation_to_adult_asthma_and_atopy_in_a_US_farming_population">House dust microbiota in relation to adult asthma and atopy in a US farming population</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="61bc77b1dc8bf9299ebffd33ab227999" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312125,"asset_id":124006067,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312125/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006067"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006067"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006067; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006066"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006066/Genome_Wide_Blood_DNA_Methylation_in_Relation_to_Recent_Use_of_Opioid_Medications"><img alt="Research paper thumbnail of Genome-Wide Blood DNA Methylation in Relation to Recent Use of Opioid Medications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006066/Genome_Wide_Blood_DNA_Methylation_in_Relation_to_Recent_Use_of_Opioid_Medications">Genome-Wide Blood DNA Methylation in Relation to Recent Use of Opioid Medications</a></div><div class="wp-workCard_item"><span>A50. VAPING, SMOKING, ALCOHOL, AND DRUG USE</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006066"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006066"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006066; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006066]").text(description); $(".js-view-count[data-work-id=124006066]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006066; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006066']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006066]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006066,"title":"Genome-Wide Blood DNA Methylation in Relation to Recent Use of Opioid Medications","internal_url":"https://www.academia.edu/124006066/Genome_Wide_Blood_DNA_Methylation_in_Relation_to_Recent_Use_of_Opioid_Medications","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006024"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006024/Antinuclear_antibodies_and_mortality_in_the_National_Health_and_Nutrition_Examination_Survey_1999_2004_"><img alt="Research paper thumbnail of Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004)" class="work-thumbnail" src="https://attachments.academia-assets.com/118312081/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006024/Antinuclear_antibodies_and_mortality_in_the_National_Health_and_Nutrition_Examination_Survey_1999_2004_">Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004)</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, Oct 9, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective Recent studies suggest antinuclear antibodies (ANA) may be related to mortality risk, b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective Recent studies suggest antinuclear antibodies (ANA) may be related to mortality risk, but evidence is sparse and inconclusive. Thus, we investigated ANA associations with all-cause and cause-specific mortality in U.S. adults. Methods Our sample included 3357 adults (ages !20 years) from the 1999-2004 National Health and Nutrition Examination Survey with ANA measurements (1:80 dilution) and mortality data through 2011 (median follow-up: 9.4 years). We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) via weighted Cox regression to assess ANA associations with mortality from all causes, cardiovascular disease (CVD), and cancer. Models adjusted for age, sex, race/ethnicity, education, and obesity. Analyses examined mortality in the full sample and in subgroups based on self-reported histories of CVD and cancer, both overall and stratified by sex and age at enrollment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afa174aa98138087063f8a9918f51ecb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312081,"asset_id":124006024,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312081/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006024"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006024"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006024; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006084/Pesticide_use_and_incident_hyperthyroidism_in_farmers_in_the_Agricultural_Health_Study"><img alt="Research paper thumbnail of Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study" class="work-thumbnail" src="https://attachments.academia-assets.com/118312110/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006084/Pesticide_use_and_incident_hyperthyroidism_in_farmers_in_the_Agricultural_Health_Study">Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span><span>, Feb 25, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Few studies have evaluated associations between pesticides and hyperthyroidism. Objec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Few studies have evaluated associations between pesticides and hyperthyroidism. Objective: We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study (AHS). Methods: We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals (CI) for associations between pesticide use at enrollment and hyperthyroidism (n=271) in 35,150 applicators (mostly men), adjusting for potential confounders. Results: Ever-use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤ 62 years) was associated with reduced hyperthyroidism risk, with hazard ratios ranging from 0.50 (95% CI: 0.30-0.83) for maneb/mancozeb to 0.77 (95% CI: 0.59-1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensityweighted lifetime days of using carbofuran and chlorpyrifos (p-trend ≤ 0.05).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dea66e5a29432f995a06dfa989e16984" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312110,"asset_id":124006084,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312110/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006084; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dea66e5a29432f995a06dfa989e16984" } } $('.js-work-strip[data-work-id=124006084]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006084,"title":"Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study","internal_url":"https://www.academia.edu/124006084/Pesticide_use_and_incident_hyperthyroidism_in_farmers_in_the_Agricultural_Health_Study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[{"id":118312110,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118312110/thumbnails/1.jpg","file_name":"pmc7866491.pdf","download_url":"https://www.academia.edu/attachments/118312110/download_file","bulk_download_file_name":"Pesticide_use_and_incident_hyperthyroidi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118312110/pmc7866491-libre.pdf?1726756576=\u0026response-content-disposition=attachment%3B+filename%3DPesticide_use_and_incident_hyperthyroidi.pdf\u0026Expires=1740000992\u0026Signature=VkqiwBYD4q0InTpwEzFTHXfwcMxM7xHI6ZyD3224Ztt6nUoEfIVotXP-Mad8FcPwP97v8G7tovQc5BXm3npPlZxcnhl2TsP58NLnhwtTadYmwh0z5Q50oazVv9NrmIt2brAoodbntICbAWP-913k8Ovk2smbYURpsKM8h5g0awfCsSOAaTZ5msFp9Oi0KY8MjzvejnDqwoygvurqCq1pJrsic9SydW1Zd~yLzuAdRxvWHwgwUuErmPE~lFKJQwJ18KxNcaiu4jfMOZQUJY01qfV609nzXF7ChOFIkrqsfF9u~Vw81jE878Ip8Lx4kZqj0Aha6BZ2x4AR4gL7r7aVVg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006083"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006083/Coffee_and_Tea_Consumption_in_Relation_to_Risk_of_Rheumatoid_Arthritis_in_the_Women%CA%BCs_Health_Initiative_Observational_Cohort"><img alt="Research paper thumbnail of Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Womenʼs Health Initiative Observational Cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/118312109/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006083/Coffee_and_Tea_Consumption_in_Relation_to_Risk_of_Rheumatoid_Arthritis_in_the_Women%CA%BCs_Health_Initiative_Observational_Cohort">Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Womenʼs Health Initiative Observational Cohort</a></div><div class="wp-workCard_item"><span>Jcr-journal of Clinical Rheumatology</span><span>, Apr 1, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives-To evaluate whether tea or coffee consumption is associated with an increased risk of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives-To evaluate whether tea or coffee consumption is associated with an increased risk of older-onset rheumatoid arthritis (RA) using the Women's Health Initiative Observational Study (WHI-OS). Methods-WHI-OS is a longitudinal prospective cohort study conducted from 1993 to 1998. 76,853 women completed a self-administered questionnaire about their daily consumption of tea and coffee. 185 self-reported and validated incident cases of RA were observed after three years of observation. Multivariable Cox proportional hazard models were performed to assess the relationship between consumption habits and disease incidence. Trend tests were calculated using categorical variables modeled as a continuous variable without collapsing. Results-There was no increase in the hazard ratio (HR) for incident RA in those participants who drank coffee compared to those who did not. The amount of coffee consumed and the method of preparation (caffeinated/decaffeinated; filtered/unfiltered) also did not alter the risk of incident RA. There was a positive association of incident RA and caffeinated tea consumption in the trend test (p=0.03). 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006080"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006080/Metagenomics_reveals_novel_microbial_signatures_of_farm_exposures_in_house_dust"><img alt="Research paper thumbnail of Metagenomics reveals novel microbial signatures of farm exposures in house dust" class="work-thumbnail" src="https://attachments.academia-assets.com/118312126/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006080/Metagenomics_reveals_novel_microbial_signatures_of_farm_exposures_in_house_dust">Metagenomics reveals novel microbial signatures of farm exposures in house dust</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Indoor home dust microbial communities, important contributors to human health outcomes, are shap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Indoor home dust microbial communities, important contributors to human health outcomes, are shaped by environmental factors, including farm-related exposures. Detection and characterization of microbiota are influenced by sequencing methodology; however, it is unknown if advanced metagenomic whole genome shotgun sequencing (WGS) can detect novel associations between environmental exposures and the indoor built-environment dust microbiome, compared to conventional 16S rRNA amplicon sequencing (16S). This study aimed to better depict indoor dust microbial communities using WGS to investigate novel associations with environmental risk factors from the homes of 781 farmers and farm spouses enrolled in the Agricultural Lung Health Study. We examined various farm-related exposures, including living on a farm, crop versus animal production, and type of animal production, as well as non-farm exposures, including home cleanliness and indoor pets. We assessed the association of the exposures...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89cbd8601e70c22070e17cfb23af683b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312126,"asset_id":124006080,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312126/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006080"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006080"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006080; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006079"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006079/Atrazine_use_and_cancer_risk_within_the_Agricultural_Health_Study_AHS_cohort_An_update"><img alt="Research paper thumbnail of Atrazine use and cancer risk within the Agricultural Health Study (AHS) cohort: An update" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006079/Atrazine_use_and_cancer_risk_within_the_Agricultural_Health_Study_AHS_cohort_An_update">Atrazine use and cancer risk within the Agricultural Health Study (AHS) cohort: An update</a></div><div class="wp-workCard_item"><span>ISEE Conference Abstracts</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006079"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006079"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006079; 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006078]").text(description); $(".js-view-count[data-work-id=124006078]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006078; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006078']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006077/The_impact_of_farm_animal_exposures_on_Campylobacter_jejuni_antibody_levels_in_rural_agricultural_communities_of_Iowa_USA"><img alt="Research paper thumbnail of The impact of farm animal exposures on Campylobacter jejuni antibody levels in rural agricultural communities of Iowa, USA" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006077/The_impact_of_farm_animal_exposures_on_Campylobacter_jejuni_antibody_levels_in_rural_agricultural_communities_of_Iowa_USA">The impact of farm animal exposures on Campylobacter jejuni antibody levels in rural agricultural communities of Iowa, USA</a></div><div class="wp-workCard_item"><span>ISEE Conference Abstracts</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006077]").text(description); $(".js-view-count[data-work-id=124006077]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006077']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006077]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006077,"title":"The impact of farm animal exposures on Campylobacter jejuni antibody levels in rural agricultural communities of Iowa, USA","internal_url":"https://www.academia.edu/124006077/The_impact_of_farm_animal_exposures_on_Campylobacter_jejuni_antibody_levels_in_rural_agricultural_communities_of_Iowa_USA","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006076"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006076/Residential_Wood_Burning_and_Pulmonary_Function_in_the_Agricultural_Lung_Health_Study"><img alt="Research paper thumbnail of Residential Wood Burning and Pulmonary Function in the Agricultural Lung Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006076/Residential_Wood_Burning_and_Pulmonary_Function_in_the_Agricultural_Lung_Health_Study">Residential Wood Burning and Pulmonary Function in the Agricultural Lung Health Study</a></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006076"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006076"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006076; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006076]").text(description); $(".js-view-count[data-work-id=124006076]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006076; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006076']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006076]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006076,"title":"Residential Wood Burning and Pulmonary Function in the Agricultural Lung Health Study","internal_url":"https://www.academia.edu/124006076/Residential_Wood_Burning_and_Pulmonary_Function_in_the_Agricultural_Lung_Health_Study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006075"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006075/Use_of_permethrin_and_other_pyrethroids_and_mortality_in_the_Agricultural_Health_Study"><img alt="Research paper thumbnail of Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006075/Use_of_permethrin_and_other_pyrethroids_and_mortality_in_the_Agricultural_Health_Study">Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesPyrethroid insecticides have been linked with multiple health outcomes. One study repor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesPyrethroid insecticides have been linked with multiple health outcomes. One study reported an association with increased all-cause and cardiovascular mortality. Given the widespread use of pyrethroids, these findings warrant confirmation. We explored associations of permethrin/pyrethroid use with overall and cause-specific mortality among 50 665 licensed pesticide applicators in the Agricultural Health Study.MethodsAt enrolment (1993–1997), participants self-reported information on permethrin/pyrethroid use. Information on causes of death came from linkage with death registries through 2016. We used Cox proportional hazards models to estimate HRs and 95% CIs with adjustment for potential confounders.ResultsOver an average 21 years of follow-up, 19.6% (9,955) of the cohort died. We found no clear evidence that ever-use of permethrin/pyrethroid was associated with elevated overall mortality or with mortality from most causes examined. There was suggestive evidence, based on ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006075"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006075]").text(description); $(".js-view-count[data-work-id=124006075]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006075']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006075]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006075,"title":"Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study","internal_url":"https://www.academia.edu/124006075/Use_of_permethrin_and_other_pyrethroids_and_mortality_in_the_Agricultural_Health_Study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006074"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006074/Completeness_of_cohort_linked_U_S_Medicare_data_An_example_from_the_Agricultural_Health_Study_1999_2016_"><img alt="Research paper thumbnail of Completeness of cohort-linked U.S. Medicare data: An example from the Agricultural Health Study (1999–2016)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006074/Completeness_of_cohort_linked_U_S_Medicare_data_An_example_from_the_Agricultural_Health_Study_1999_2016_">Completeness of cohort-linked U.S. Medicare data: An example from the Agricultural Health Study (1999–2016)</a></div><div class="wp-workCard_item"><span>Preventive Medicine Reports</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highlights • We describe linked U.S. Medicare claims data in the Agricultural Health Study.• Inco...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highlights • We describe linked U.S. Medicare claims data in the Agricultural Health Study.• Incomplete claims data were related to geographic, demographic, and health.• We saw potential informative missingness by pesticide use and mortality.• Incomplete data in Medicare-linked cohorts may impact sample size and validity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006074"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006074"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006074; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006074]").text(description); $(".js-view-count[data-work-id=124006074]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006074; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006074']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006073"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006073/Agricultural_Pesticides_and_Shingles_Risk_in_a_Prospective_Cohort_of_Licensed_Pesticide_Applicators"><img alt="Research paper thumbnail of Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006073/Agricultural_Pesticides_and_Shingles_Risk_in_a_Prospective_Cohort_of_Licensed_Pesticide_Applicators">Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators</a></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Some pesticides are immunotoxic and have been associated with an increased risk of im...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Some pesticides are immunotoxic and have been associated with an increased risk of immune-mediated diseases. The risk of shingles, the clinical reactivation of varicella-zoster virus, increases with aging and immunosuppression; little is known about its associations with pesticides. Objective: We examined the use of agricultural pesticides in relation to incident shingles in a prospective cohort of licensed pesticide applicators. Methods: The study sample included 12,820 (97% male) farmers (enrolled in 1993–1997 in North Carolina and Iowa), who were followed for a median of 12 y (interquartile range: 11–13). Shingles was self-reported at enrollment and at follow-up. We evaluated ever-use of 48 agricultural pesticides reported at study enrollment in relation to shingles risk and considered exposure–response for intensity-weighted lifetime days (IWLDs) of use. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard models, adjusting for state, and allowing estimates to vary by median attained age (60 y). Results: Incident shingles was reported by 590 participants. Associations were positive (HRs&gt;1.2) for ever- vs. never-use of eight insecticides, three fumigants, two fungicides, and five herbicides, and exposure–response trends were seen across increasing quartiles (Q3 and Q4&gt;Q1) or tertiles (T3 and T2&gt;T1) of IWLDs for four insecticides [permethrin (crops), coumaphos, malathion, and lindane], two fumigants (carbon tetrachloride/carbon disulfide and methyl bromide), and three herbicides [alachlor, trifluralin (&lt;60 years of age) and 2,4-dichlorophenoxyacetic acid]. Shingles was not associated with total years or days per year mixed or applied any pesticides, but in older participants, shingles was associated with a history of a high pesticide exposure event [HR=1.89 (95% CI: 1.45, 2.45)]. Conclusions: Several specific pesticides were associated with increased risk of shingles in farmers, especially at higher levels of cumulative use. These novel findings, if replicated in other populations, could have broader implications for the potential effects of pesticides on vaccine efficacy and susceptibility to other infections. <a href="https://doi.org/10.1289/EHP7797" rel="nofollow">https://doi.org/10.1289/EHP7797</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006073"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006073"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006073; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006073]").text(description); $(".js-view-count[data-work-id=124006073]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006073; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006073']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006073]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006073,"title":"Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators","internal_url":"https://www.academia.edu/124006073/Agricultural_Pesticides_and_Shingles_Risk_in_a_Prospective_Cohort_of_Licensed_Pesticide_Applicators","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006072"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006072/Residential_proximity_to_animal_feeding_operations_and_risk_of_solid_tumors_in_the_Agricultural_Health_Study_cohort"><img alt="Research paper thumbnail of Residential proximity to animal feeding operations and risk of solid tumors in the Agricultural Health Study cohort" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006072/Residential_proximity_to_animal_feeding_operations_and_risk_of_solid_tumors_in_the_Agricultural_Health_Study_cohort">Residential proximity to animal feeding operations and risk of solid tumors in the Agricultural Health Study cohort</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006072"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006072"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006072; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006072]").text(description); $(".js-view-count[data-work-id=124006072]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006072; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006072']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006071"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006071/Use_of_specific_pesticides_is_associated_with_increased_risk_of_developing_shingles_in_the_Agricultural_Health_Study"><img alt="Research paper thumbnail of Use of specific pesticides is associated with increased risk of developing shingles in the Agricultural Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006071/Use_of_specific_pesticides_is_associated_with_increased_risk_of_developing_shingles_in_the_Agricultural_Health_Study">Use of specific pesticides is associated with increased risk of developing shingles in the Agricultural Health Study</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006071"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006071"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006071; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006071]").text(description); $(".js-view-count[data-work-id=124006071]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006071; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006071']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006071]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006071,"title":"Use of specific pesticides is associated with increased risk of developing shingles in the Agricultural Health Study","internal_url":"https://www.academia.edu/124006071/Use_of_specific_pesticides_is_associated_with_increased_risk_of_developing_shingles_in_the_Agricultural_Health_Study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006070"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006070/Pesticide_use_and_kidney_function_among_farmers_in_the_Biomarkers_of_Exposure_and_Effect_in_Agriculture_study"><img alt="Research paper thumbnail of Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006070/Pesticide_use_and_kidney_function_among_farmers_in_the_Biomarkers_of_Exposure_and_Effect_in_Agriculture_study">Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study</a></div><div class="wp-workCard_item"><span>Environmental Research</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Pesticides have been reported to be associated with malignant and non-malignant kidney...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Pesticides have been reported to be associated with malignant and non-malignant kidney disease. Few studies have examined the relationship between individual pesticides and kidney dysfunction. OBJECTIVE We evaluated the associations of pesticide use with measured kidney function among male pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study, a subcohort in the Agricultural Health Study. METHODS Serum creatinine was measured in 1,545 BEEA participants and estimated glomerular filtration rate (eGFR) was calculated with the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. Using reported information on lifetime use of 41 pesticides, multivariable linear and logistic regression was used to examine associations with eGFR modeled continuously and with CKD (eGFR &lt;60 mL/min/1.73 m2), respectively. Models were adjusted for possible confounding factors related to kidney function and correlated pesticides. RESULTS Lower eGFR was observed among pesticide applicators who ever used the herbicides pendimethalin (-3.7%, 95% confidence interval (CI): -5.8%, -1.5%), atrazine (-3.7%, 95% CI: -6.9%, -0.4%), and dicamba (-2.8%, 95% CI: -5.3%, -0.2%) compared with never users of each pesticide. Ever use of pendimethalin (odds ratio (OR)=1.6, 95% CI: 1.1, 2.2) and atrazine (OR=1.8, 95% CI: 1.0, 3.0) was also associated with elevated odds of CKD, with an exposure-response association between intensity-weighted lifetime days of pendimethalin use and CKD among active farmers (N=1,302; ptrend=0.04). Atrazine use within the last year was associated with lower eGFR and elevated odds of CKD when compared with never users, and we observed exposure-response associations with intensity-weighted lifetime days among recent users. Use of several other pesticides was associated with higher eGFR. DISCUSSION These results suggest that two widely used herbicides, pendimethalin and atrazine, may be associated with altered kidney function among pesticide applicators. Our findings for these herbicides are consistent with observed associations with end-stage renal disease in the Agricultural Health Study.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006070"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006070"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006070; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006070]").text(description); $(".js-view-count[data-work-id=124006070]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006070; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006070']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006070]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006070,"title":"Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study","internal_url":"https://www.academia.edu/124006070/Pesticide_use_and_kidney_function_among_farmers_in_the_Biomarkers_of_Exposure_and_Effect_in_Agriculture_study","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006069"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006069/Exposure_to_pesticides_and_oxidative_stress_in_Brazilian_agricultural_communities"><img alt="Research paper thumbnail of Exposure to pesticides and oxidative stress in Brazilian agricultural communities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006069/Exposure_to_pesticides_and_oxidative_stress_in_Brazilian_agricultural_communities">Exposure to pesticides and oxidative stress in Brazilian agricultural communities</a></div><div class="wp-workCard_item"><span>Biomarkers</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Background Oxidative stress may be an important mechanism linking pesticide exposure to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Background Oxidative stress may be an important mechanism linking pesticide exposure to several diseases. We evaluated the association between pesticide exposures and oxidative stress biomarkers in Brazilian agricultural workers. Methods A cross-sectional study was conducted in healthy agricultural (N = 52) and non-agricultural workers (N = 68) in a rural community in Rio de Janeiro State, Brazil. Regular pesticide use, sociodemographic, and lifestyle information was obtained by questionnaire. Oxidative stress biomarkers (N = 7) were measured in serum and plasma. We calculated percent differences and 95% confidence intervals (CI) in oxidative stress biomarkers for use of pesticides adjusted for sex, age, education, smoking, and alcohol consumption, using multiple linear regression. Results Living close to or in the fields was associated with glutathione peroxidase activity but not with any other markers. We observed significant positive associations between 8-isoprostane levels and activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase with reported use of certain insecticides, fungicides, and herbicides. Our results also indicate a significant and negative association between glutathione-S-transferase activity and insecticide use. Conclusions These findings suggest that use of pesticides may be associated with differences in oxidative stress biomarkers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006069"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006069]").text(description); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006069]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006069,"title":"Exposure to pesticides and oxidative stress in Brazilian agricultural communities","internal_url":"https://www.academia.edu/124006069/Exposure_to_pesticides_and_oxidative_stress_in_Brazilian_agricultural_communities","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006068"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006068/Lifetime_Pesticide_Use_and_Monoclonal_Gammopathy_of_Undetermined_Significance_in_a_Prospective_Cohort_of_Male_Farmers"><img alt="Research paper thumbnail of Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006068/Lifetime_Pesticide_Use_and_Monoclonal_Gammopathy_of_Undetermined_Significance_in_a_Prospective_Cohort_of_Male_Farmers">Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers</a></div><div class="wp-workCard_item"><span>Environmental Health Perspectives</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Farmers have a higher incidence of multiple myeloma, and there is suggestive evidence...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Farmers have a higher incidence of multiple myeloma, and there is suggestive evidence of an elevated prevalence of its precursor, monoclonal gammopathy of undetermined significance (MGUS), relative to the general population. Pesticide exposures are suspected to play a role; however, the biologic plausibility for associations with multiple myeloma remains unclear. Objectives: Our objectives were to examine the prevalence of MGUS and evaluate associations with a wide range of pesticides in a large sample of farmers. Methods: We obtained sera and assessed MGUS among 1,638 male farmers ≥50 years of age in the Agricultural Health Study (AHS), a prospective cohort in Iowa and North Carolina. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed to estimate associations with MGUS for recent use (within the 12 months before phlebotomy) and cumulative intensity-weighted lifetime days of use of specific pesticides. Results: The age-standardized MGUS prevalence was significantly elevated among AHS farmers (7.7%) compared with demographically similar men in the National Health and Nutrition Examination Survey (2.8%) or Olmsted County, Minnesota (3.8%; p&lt;0.001). Recent use of permethrin was associated with MGUS [recent use vs. no recent use, OR=1.82 (95% CI: 1.06, 3.13)], especially among those who had also used it in the past [recent and past use vs. never use, OR=2.49 (95% CI: 1.32, 4.69)]. High intensity-weighted lifetime use of the organochlorine insecticides aldrin and dieldrin was associated with MGUS relative to those who never used either of these pesticides [OR=2.42 (95% CI: 1.29, 4.54); ptrend=0.006]. We also observed a positive association with high lifetime use of petroleum oil/distillates as an herbicide, as well as an inverse association with fonofos use. Discussion: This is the largest investigation of MGUS in farmers and the first to identify an association with MGUS for permethrin, a pyrethroid insecticide previously associated with multiple myeloma. Given the continued widespread use of permethrin in various residential and commercial settings, our findings may have important implications for exposed individuals in the general population. <a href="https://doi.org/10.1289/EHP6960" rel="nofollow">https://doi.org/10.1289/EHP6960</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006068"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006068"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006068; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="124006067"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006067/House_dust_microbiota_in_relation_to_adult_asthma_and_atopy_in_a_US_farming_population"><img alt="Research paper thumbnail of House dust microbiota in relation to adult asthma and atopy in a US farming population" class="work-thumbnail" src="https://attachments.academia-assets.com/118312125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006067/House_dust_microbiota_in_relation_to_adult_asthma_and_atopy_in_a_US_farming_population">House dust microbiota in relation to adult asthma and atopy in a US farming population</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="61bc77b1dc8bf9299ebffd33ab227999" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312125,"asset_id":124006067,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312125/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006067"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006067"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006067; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006066"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124006066/Genome_Wide_Blood_DNA_Methylation_in_Relation_to_Recent_Use_of_Opioid_Medications"><img alt="Research paper thumbnail of Genome-Wide Blood DNA Methylation in Relation to Recent Use of Opioid Medications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124006066/Genome_Wide_Blood_DNA_Methylation_in_Relation_to_Recent_Use_of_Opioid_Medications">Genome-Wide Blood DNA Methylation in Relation to Recent Use of Opioid Medications</a></div><div class="wp-workCard_item"><span>A50. VAPING, SMOKING, ALCOHOL, AND DRUG USE</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006066"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006066"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006066; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124006066]").text(description); $(".js-view-count[data-work-id=124006066]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124006066; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124006066']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124006066]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124006066,"title":"Genome-Wide Blood DNA Methylation in Relation to Recent Use of Opioid Medications","internal_url":"https://www.academia.edu/124006066/Genome_Wide_Blood_DNA_Methylation_in_Relation_to_Recent_Use_of_Opioid_Medications","owner_id":42009732,"coauthors_can_edit":true,"owner":{"id":42009732,"first_name":"Christine","middle_initials":null,"last_name":"Parks","page_name":"ChristineParks","domain_name":"independent","created_at":"2016-01-24T10:03:39.642-08:00","display_name":"Christine Parks","url":"https://independent.academia.edu/ChristineParks"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124006024"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124006024/Antinuclear_antibodies_and_mortality_in_the_National_Health_and_Nutrition_Examination_Survey_1999_2004_"><img alt="Research paper thumbnail of Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004)" class="work-thumbnail" src="https://attachments.academia-assets.com/118312081/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124006024/Antinuclear_antibodies_and_mortality_in_the_National_Health_and_Nutrition_Examination_Survey_1999_2004_">Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004)</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, Oct 9, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective Recent studies suggest antinuclear antibodies (ANA) may be related to mortality risk, b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective Recent studies suggest antinuclear antibodies (ANA) may be related to mortality risk, but evidence is sparse and inconclusive. Thus, we investigated ANA associations with all-cause and cause-specific mortality in U.S. adults. Methods Our sample included 3357 adults (ages !20 years) from the 1999-2004 National Health and Nutrition Examination Survey with ANA measurements (1:80 dilution) and mortality data through 2011 (median follow-up: 9.4 years). We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) via weighted Cox regression to assess ANA associations with mortality from all causes, cardiovascular disease (CVD), and cancer. Models adjusted for age, sex, race/ethnicity, education, and obesity. Analyses examined mortality in the full sample and in subgroups based on self-reported histories of CVD and cancer, both overall and stratified by sex and age at enrollment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afa174aa98138087063f8a9918f51ecb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118312081,"asset_id":124006024,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118312081/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124006024"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124006024"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124006024; 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