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Pembrolizumab - NCI
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It is a monoclonal antibody that binds to the protein PD-1 on the surface of immune cells called T cells. It works by keeping cancer cells from suppressing the immune system. This allows the immune system to attack and kill the cancer cells.</p><div class="two-columns brand-fda"><div class="column1">US Brand Name(s)</div><div class="column2">Keytruda</div></div><div class="two-columns brand-fda"><div class="column1">FDA Approved</div><div class="column2">Yes</div></div><div class="accordion"><p id="" tabindex="-1"><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287&audience=consumer">FDA label information for this drug is available at DailyMed.</a></p><h2>Use in Cancer</h2> <p id="_2" tabindex="-1">Pembrolizumab is approved to treat:</p> <ul id="_3"> <li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=559456&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000559456&version=Patient&language=English'); return(false);">Biliary tract</a> cancer</strong> that has spread or cannot be removed by surgery. It is used with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=508951&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000508951&version=Patient&language=English'); return(false);">gemcitabine hydrochloride</a> and <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45230&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045230&version=Patient&language=English'); return(false);">cisplatin</a>.</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444971&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444971&version=Patient&language=English'); return(false);">Breast cancer</a></strong> that is <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=639916&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000639916&version=Patient&language=English'); return(false);">triple negative</a>. Pembrolizumab is used:<ul id="_16"><li>with chemotherapy in patients whose cancer has the <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=797389&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000797389&version=Patient&language=English'); return(false);">PD-L1</a> protein and has come back and cannot be removed by surgery or has spread</li><li>with chemotherapy before surgery and then alone after surgery in patients with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=561398&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000561398&version=Patient&language=English'); return(false);">early-stage cancer</a> that has a <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45079&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045079&version=Patient&language=English'); return(false);">high risk</a> of coming back</li></ul> </li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444973&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444973&version=Patient&language=English'); return(false);">Cervical cancer</a>.</strong> Pembrolizumab is used:<ul id="_17"><li>with chemotherapy and radiation therapy in patients with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45888&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045888&version=Patient&language=English'); return(false);">stage III</a> or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45889&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045889&version=Patient&language=English'); return(false);">stage IVA cervical cancer</a></li><li>with chemotherapy, with or without <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46115&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046115&version=Patient&language=English'); return(false);">bevacizumab</a>, in patients whose cancer has the PD-L1 protein and did not respond to treatment, has come back, or has spread to other parts of the body</li><li>alone in patients whose cancer has the PD-L1 protein, has come back or spread to other parts of the body, and has gotten worse during or after chemotherapy</li></ul> </li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=574284&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000574284&version=Patient&language=English'); return(false);">Classic Hodgkin lymphoma</a>.</strong> Pembrolizumab is used:<ul id="_14"><li>in adults whose cancer does not respond to treatment or has <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45866&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045866&version=Patient&language=English'); return(false);">relapsed</a></li><li>in children whose cancer is refractory or has relapsed after at least two other types of treatment</li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=795104&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000795104&version=Patient&language=English'); return(false);">Cutaneous squamous cell carcinoma</a></strong> (a type of <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=445084&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000445084&version=Patient&language=English'); return(false);">skin cancer</a>) that has spread or come back. Pembrolizumab is used in patients whose cancer cannot be cured with surgery or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=44971&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000044971&version=Patient&language=English'); return(false);">radiation therapy</a>.</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444987&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444987&version=Patient&language=English'); return(false);">Endometrial carcinoma</a></strong> in adults. Pembrolizumab is used:<ul id="_20"><li>with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45182&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045182&version=Patient&language=English'); return(false);">carboplatin</a> and <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45258&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045258&version=Patient&language=English'); return(false);">paclitaxel</a> and then alone in patients with cancer that has spread or has come back</li><li>with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=769612&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000769612&version=Patient&language=English'); return(false);">lenvatinib</a> in patients with cancer that is not <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=285933&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000285933&version=Patient&language=English'); return(false);">microsatellite instability</a>-high (MSI-H) or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=789741&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000789741&version=Patient&language=English'); return(false);">mismatch repair deficient</a> (dMMR), has gotten worse after other <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45922&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045922&version=Patient&language=English'); return(false);">systemic therapies</a>, and cannot be cured with surgery or radiation therapy</li><li>alone in patients with cancer that is MSI-H or dMMR, cannot be cured with surgery or radiation therapy, and has gotten worse after other systemic therapies</li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444989&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444989&version=Patient&language=English'); return(false);">Esophageal</a></strong> or<strong> <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=302458&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000302458&version=Patient&language=English'); return(false);">gastroesophageal junction</a> cancer</strong> that has spread and cannot be cured <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=318813&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000318813&version=Patient&language=English'); return(false);"></a> with surgery or a combination of chemotherapy and radiation therapy. Pembrolizumab is used:<ul id="_15"><li>with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45841&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045841&version=Patient&language=English'); return(false);">platinum</a>-based chemotherapy and a <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=386207&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000386207&version=Patient&language=English'); return(false);">fluoropyrimidine</a></li><li>alone in patients with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46595&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046595&version=Patient&language=English'); return(false);">squamous cell cancer</a> that has the PD-L1 protein and has been treated with systemic therapy</li></ul> </li> <li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=454513&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000454513&version=Patient&language=English'); return(false);">Gastric (stomach) cancer</a></strong> or <strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=302458&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000302458&version=Patient&language=English'); return(false);">gastroesophageal junction</a> <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46216&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046216&version=Patient&language=English'); return(false);">adenocarcinoma</a></strong> that has spread or cannot be treated with surgery. Pembrolizumab is used as the first treatment with: <ul id="_21"><li><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45439&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045439&version=Patient&language=English'); return(false);">trastuzumab</a>, a fluoropyrimidine, and platinum-based chemotherapy in patients whose cancer has the PD-L1 protein and is <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=737998&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000737998&version=Patient&language=English'); return(false);">HER2 positive</a>¹</li><li>fluoropyrimidine and platinum-based chemotherapy in patients whose cancer is <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=774531&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000774531&version=Patient&language=English'); return(false);">HER2 negative</a></li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46363&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046363&version=Patient&language=English'); return(false);">Hepatocellular carcinoma</a></strong> (a type of <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=44242&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000044242&version=Patient&language=English'); return(false);">liver cancer</a>) in patients who have been treated with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=509041&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000509041&version=Patient&language=English'); return(false);">sorafenib</a>.</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45135&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045135&version=Patient&language=English'); return(false);">Melanoma</a></strong>. Pembrolizumab is used in:<ul id="_9"><li>patients whose cancer cannot be removed by surgery or has spread to other parts of the body </li><li> adults and children aged 12 years and older with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45137&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045137&version=Patient&language=English'); return(false);">stage IIB</a>, stage IIC, or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45138&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045138&version=Patient&language=English'); return(false);">stage III melanoma</a> to prevent the cancer from coming back after it has been removed by surgery</li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=44323&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000044323&version=Patient&language=English'); return(false);">Malignant pleural mesothelioma</a>.</strong> Pembrolizumab is given with pemetrexed and platinum chemotherapy as the first treatment in adults whose cancer has spread or cannot be removed by surgery.</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=658511&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000658511&version=Patient&language=English'); return(false);">Merkel cell carcinoma</a></strong> in adults and children. Pembrolizumab is used in patients whose cancer has come back or spread.</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=285933&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000285933&version=Patient&language=English'); return(false);">Microsatellite instability</a>-high (MSI-H) or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=789741&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000789741&version=Patient&language=English'); return(false);">mismatch repair deficient</a> (dMMR) cancer</strong> that is has spread to other parts of the body or cannot be removed by surgery. Pembrolizumab is used to treat:<ul id="_6"><li><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45301&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045301&version=Patient&language=English'); return(false);">solid tumors</a> in adults and children that got worse after other treatment and cannot be treated with other therapies</li><li><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444983&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444983&version=Patient&language=English'); return(false);">colorectal cancer</a></li></ul><p id="_7" tabindex="-1">MSI-H and dMMR cancers have certain <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46391&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046391&version=Patient&language=English'); return(false);">genetic</a> <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46063&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046063&version=Patient&language=English'); return(false);">mutations</a> and may not respond to some types of treatment.</p></li> <li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45323&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045323&version=Patient&language=English'); return(false);">Non-small cell lung cancer</a>.</strong> Pembrolizumab is used:<ul id="_5"><li>with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45456&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045456&version=Patient&language=English'); return(false);">pemetrexed</a> and platinum-based chemotherapy as the first treatment in patients with nonsquamous cancer that has spread to other parts of the body and does not have a mutation in the <em class="gene-name"><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=796876&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000796876&version=Patient&language=English'); return(false);">EGFR</a></em> gene or <em class="gene-name"><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=721252&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000721252&version=Patient&language=English'); return(false);">ALK</a></em> gene</li><li>with carboplatin and either paclitaxel or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=507600&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000507600&version=Patient&language=English'); return(false);">paclitaxel albumin-stabilized nanoparticle formulation</a> as the first treatment for <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46056&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046056&version=Patient&language=English'); return(false);">squamous</a> cancer that has spread to other parts of the body</li><li>with platinum-based chemotherapy before surgery and then alone as <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45587&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045587&version=Patient&language=English'); return(false);">adjuvant therapy</a>, to help keep the cancer from coming back after surgery</li><li>alone as the first treatment in patients with cancer that has the PD-L1 protein, does not have a mutation in the <em class="gene-name">EGFR</em> gene or <em class="gene-name">ALK</em> gene, and is either stage III and cannot be treated with surgery or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=306495&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000306495&version=Patient&language=English'); return(false);">chemoradiation</a> or has spread to other parts of the body</li><li>alone in patients with cancer that has spread to other parts of the body, has the PD-L1 protein, and has gotten worse during or after treatment with platinum-based chemotherapy; if the cancer has <em class="gene-name">EGFR</em> or <em class="gene-name">ALK</em> gene mutations, patients must have received <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=532303&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000532303&version=Patient&language=English'); return(false);">EGFR inhibitor</a> or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=795666&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000795666&version=Patient&language=English'); return(false);">ALK inhibitor</a> therapy and it did not work or is no longer working</li><li>alone in adults with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=682415&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000682415&version=Patient&language=English'); return(false);">stage IB</a>, <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45357&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045357&version=Patient&language=English'); return(false);">stage IIA</a>, <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=682419&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000682419&version=Patient&language=English'); return(false);">stage IIB</a>, or <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45367&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045367&version=Patient&language=English'); return(false);">stage IIIA</a> cancer, to help keep the cancer from coming back after platinum-based chemotherapy and surgery</li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=777025&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000777025&version=Patient&language=English'); return(false);">Primary mediastinal large B-cell lymphoma</a>.</strong> Pembrolizumab is used in adults and children whose cancer does not respond to treatment or has returned after at least two other therapies.</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=661352&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000661352&version=Patient&language=English'); return(false);">Renal cell carcinoma</a></strong> (a type of <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444995&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444995&version=Patient&language=English'); return(false);">kidney cancer</a>). It is used:<ul id="_19"><li>with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=538635&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000538635&version=Patient&language=English'); return(false);">axitinib</a> or lenvatinib as the first treatment in patients whose cancer has spread or cannot be removed by surgery</li><li>as adjuvant therapy in patients whose cancer has a high risk of coming back after surgery to remove the kidney or surgery to remove the kidney and metastatic cancer</li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=45301&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000045301&version=Patient&language=English'); return(false);">Solid tumors</a></strong> that are <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=795825&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000795825&version=Patient&language=English'); return(false);">tumor mutational burden</a>-high (TMB-H) and have spread to other parts of the body or cannot be removed by surgery. Pembrolizumab is used in adults and children whose cancer got worse after treatment and who are not able to receive other therapies.¹</li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=597171&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000597171&version=Patient&language=English'); return(false);">Squamous cell carcinoma of the head and neck</a></strong> that has come back or has spread to other parts of the body. Pembrolizumab is used:<ul id="_12"><li>with platinum-based chemotherapy and <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46090&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046090&version=Patient&language=English'); return(false);">fluorouracil</a> as the first treatment in patients whose cancer cannot be removed by surgery</li><li>alone as the first treatment in patients whose cancer cannot be removed by surgery and whose tumors have the PD-L1 protein</li><li>alone in patients whose cancer got worse during or after treatment with platinum-based chemotherapy</li></ul></li><li><strong><a class="definition" href="/Common/PopUps/popDefinition.aspx?id=783188&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000783188&version=Patient&language=English'); return(false);">Urothelial carcinoma</a></strong> (a type of <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=444968&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000444968&version=Patient&language=English'); return(false);">bladder cancer</a>). Pembrolizumab is used:<ul id="_8"><li>with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=800193&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000800193&version=Patient&language=English'); return(false);">enfortumab vedotin</a> in adults whose cancer has spread</li><li>alone in patients whose cancer has spread and cannot be treated with platinum-based chemotherapy or has gotten worse during or after treatment with platinum-based chemotherapy</li><li>alone in patients with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=46488&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000046488&version=Patient&language=English'); return(false);">carcinoma in situ</a>, a type of bladder cancer that has not spread to the bladder muscle but is at high risk of spreading, that did not respond to treatment with <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=746944&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000746944&version=Patient&language=English'); return(false);">bacillus Calmette-Guérin</a> (BCG), when surgery is not an option for health or personal reasons</li></ul> </li></ul> <p id="_11" tabindex="-1">¹This use is approved under FDA’s <a href="https://www.fda.gov/ForPatients/Approvals/Fast/ucm405447.htm">Accelerated Approval Program</a>. As a condition of approval, <a class="definition" href="/Common/PopUps/popDefinition.aspx?id=799146&version=Patient&language=English" onclick="javascript:popWindow('defbyid','CDR0000799146&version=Patient&language=English'); return(false);">confirmatory trial(s)</a> must show that pembrolizumab provides a clinical benefit in these patients.</p><p id="_4" tabindex="-1">Pembrolizumab is also being studied in the treatment of other types of cancer. </p><h2>More About Pembrolizumab</h2><p id="_Dict_1" tabindex="-1"><a href="https://www.cancer.gov/publications/dictionaries/cancer-drug/def/695789">Definition from the NCI Drug Dictionary</a> - Detailed scientific definition and other names for this drug.</p> <p id="_About_8.106" tabindex="-1">MedlinePlus Information on <a href="https://medlineplus.gov/druginfo/meds/a614048.html">Pembrolizumab</a> - A lay language summary of important information about this drug that may include the following:</p> <ul id="_About_9.107"><li>warnings about this drug,</li><li>what this drug is used for and how it is used,</li><li>what you should tell your doctor before using this drug,</li><li>what you should know about this drug before using it, </li><li>other drugs that may interact with this drug, and</li><li>possible side effects. </li></ul><p id="_About_10.108" tabindex="-1">Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.</p><h2>Research Results and Related Resources</h2><p id="" tabindex="-1"><a href="https://www.cancer.gov/news-events/cancer-currents-blog/2024/endometrial-cancer-durvalumab-pembrolizumab-chemotherapy">More Immunotherapy Options Approved for Treating Endometrial Cancer</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/news-events/cancer-currents-blog/2024/kidney-cancer-pembrolizumab-increases-survival">Pembrolizumab Provides First-Ever Overall Survival Improvement in Kidney Cancer</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/news-events/cancer-currents-blog/2023/bladder-cancer-padcev-keytruda-doubles-survival">Groundbreaking Trial Results Expand Treatment Options for Some People with Bladder Cancer Effects</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/news-events/cancer-currents-blog/2023/fda-pembrolizumab-stomach-esophageal-her2-pdl1">FDA Amends Approval of Pembrolizumab to Treat Stomach and Esophageal Junction Cancer</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/news-events/cancer-currents-blog/2023/immunotherapy-mismatch-repair-biomarker">A Better Biomarker for Cancer Immunotherapy?</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies">Targeted Therapy to Treat Cancer</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/monoclonal-antibodies">Monoclonal Antibodies</a></p><p id="" tabindex="-1"><a href="https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/checkpoint-inhibitors">Immune Checkpoint Inhibitors</a></p><h2>Clinical Trials Accepting Patients</h2><p id="_ClinicalTrial_2" tabindex="-1"><a href="https://www.cancer.gov/research/participate/clinical-trials/intervention/C106432">Find Clinical Trials for Pembrolizumab</a> - Check for trials from NCI's list of cancer clinical trials now accepting patients.</p><aside class="dis-disclaimer"> <p id="_Disclaimer_4" tabindex="-1"><strong>Important: </strong>The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug. </p></aside></div></div></div> </div> </div> <footer class="article-footer"> <div class="document-dates horizontal"> <ul class="clearfix"> <li> <strong>Posted:</strong> <time datetime="2014-09-18T12:00:00Z">September 18, 2014</time> </li> <li> <strong>Updated:</strong> <time datetime="2024-09-20T12:00:00Z">September 20, 2024</time> </li> </ul> </div> </footer> </article> </main> </div> </div> <div class="desktop:grid-col-9 desktop:grid-offset-3"> <section class="cgdp-page-options cgdp-page-options--bottom" aria-label="Page options bottom"> <button class="usa-button usa-button--unstyled" onclick="window.print()"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24" class="usa-icon" role="img" aria-hidden="true" focusable="false"> <path d="M0 0h24v24H0z" fill="none"/> <path d="M19 8H5c-1.66 0-3 1.34-3 3v6h4v4h12v-4h4v-6c0-1.66-1.34-3-3-3zm-3 11H8v-5h8v5zm3-7c-.55 0-1-.45-1-1s.45-1 1-1 1 .45 1 1-.45 1-1 1zm-1-9H6v4h12V3z"/> </svg> <span class="usa-sr-only"> Print </span> </button> <a class="usa-button usa-button--unstyled" href="mailto:?subject=Information from the National Cancer Institute Web Site &body=I found this information on www.cancer.gov and I'd like to share it with you: https://www.cancer.gov/about-cancer/treatment/drugs/pembrolizumab %0D%0A%0D%0A NCI's Web site, www.cancer.gov, provides accurate, up-to-date, comprehensive cancer information from the U.S. government's principal agency for cancer research. 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