<i>GPR174</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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</ul> <div style="clear:both;"></div> </div>   <div class="grid_12">  <div class="grid_16 alpha"> <a name="top"></a> <h4><i>GPR174</i></h4> <div class="contentboxfullhelp"> <div class="imageleft"> <a style="color:white;" href="JavaScript:callRef('helpPagePopup.jsp#targetName', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small.png" alt="Click here for help"/></a> </div> <div class="textright_float"> <p> Target <b>not</b> currently curated in GtoImmuPdb <br/><br/> <button class="button_gtoimmupdb_off" onClick='window.location.href="http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=145"; return false;'>GtoImmuPdb View OFF</button> </p> </div> <div class="textmiddle"> <p> <b>Target id:</b> 145 </p> <p> <b>Nomenclature:</b> <i>GPR174</i> </p> <p> <b>Family:</b> <a href="FamilyDisplayForward?familyId=16">Class A Orphans</a></li> </p> <p class="lp"> This receptor has a proposed ligand; see the <a href="/latestPairings.jsp">Latest Pairings</a> page for more information. </p> </div> </div> </div>   <div class="grid_16 alpha list"> <h4>Contents:</h4> <ul style="list-style:none;"> <li><a href="#StructuralInfo">Gene and Protein Information</a></li> <li><a href="#OtherNames">Previous and Unofficial Names</a></li> <li><a href="#DatabaseLinks">Database Links</a></li> <li><a href="#Endogenous">Natural/Endogenous Ligands</a></li> <li><a href="#Agonists">Agonists</a></li> <li><a href="#Processes">Immuno Process Associations</a></li> <li><a href="#Expression">Expression Datasets</a></li> <li><a href="#Mutations">Clinically-Relevant Mutations and Pathophysiology</a></li> <li><a href="#GeneExpressionPathophysiology">Gene Expression and Pathophysiology</a></li> <li><a href="#variants">Biologically Significant Variants</a></li> <li><a href="#references">References</a></li> <li><a href="#Contributors">Contributors</a></li> <li><a href="#citing">How to cite this page</a></li> </ul> </div>   <div class="grid_16 alpha"> <div class="contentboxfullhelp"> <div class="data_tables_container"> <a name="StructuralInfo"></a> <table class="receptor_data_tables fullwidth"> <thead> <tr name="hotspot" class="hotspot"> <td class="info category" colspan="7" >Gene and Protein Information <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#structuralInfo', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> </thead> <tbody name="toggle"> <tr> <td class="info" colspan="7"> class A G protein-coupled receptor</td> </tr> <tr> <td class="info heading">Species</td> <td class="info heading">TM</td> <td class="info heading">AA</td> <td class="info heading">Chromosomal Location</td> <td class="info heading">Gene Symbol</td> <td class="info heading">Gene Name</td> <td class="info heading">Reference</td> </tr> <tr> <td class="info centre">Human</td> <td class="info centre">7</td> <td class="info centre">333</td> <td class="info centre">Xq21.1</td> <td class="info centre"> <a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30245" title="HUGO Gene Nomenclature Committee (HGNC) database" target="_blank" onClick="recordEvent(this, 'Target database links', 'https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30245', 'HUGO Gene Nomenclature Committee (HGNC) database');return false;"> <i>GPR174</i> </a> </td> <td class="info centre"> G protein-coupled receptor 174 </td> <td class="info centre"></td> </tr> <tr> <td class="info centre">Mouse</td> <td class="info centre">7</td> <td class="info centre">335</td> <td class="info centre">X D</td> <td class="info centre"> <a href="http://www.informatics.jax.org/marker/MGI:2685222" title="Mouse Genome Database (MGD) at the Mouse Genome Informatics (MGI) website" target="_blank" onClick="recordEvent(this, 'Target database links', 'http://www.informatics.jax.org/marker/MGI:2685222', 'Mouse Genome Database (MGD) at the Mouse Genome Informatics (MGI) website');return false;"> <i>Gpr174</i> </a> </td> <td class="info centre"> G protein-coupled receptor 174 </td> <td class="info centre"></td> </tr> <tr> <td class="info centre">Rat</td> <td class="info centre">7</td> <td class="info centre">335</td> <td class="info centre">Xq31</td> <td class="info centre"> <a href="https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1564689" title="Rat Genome Database (RGD)" target="_blank" onClick="recordEvent(this, 'Target database links', 'https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1564689', 'Rat Genome Database (RGD)');return false;"> <i>Gpr174</i> </a> </td> <td class="info centre"> G protein-coupled receptor 174 </td> <td class="info centre"></td> </tr> </tbody> </table> <a name="OtherNames"></a> <table class="receptor_data_tables fullwidth" > <tr> <td class="info category" >Previous and Unofficial Names <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#synonyms', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr> <td class="info"> FKSG79 </td> </tr> </table> </td> <a name="DatabaseLinks"></a> <table class="receptor_data_tables fullwidth"> <tr> <td class="info category" colspan="2">Database Links <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#DBLinks', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr> <td class="info" colspan="2" style="font-style: italic; font-weight: bold;"> Specialist databases </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> GPCRdb </td> <td class="info"> <a href="http://gpcrdb.org/protein/gp174_human" target="_blank" title="Tools for visualising and analysing data on sequence and structure of GPCRs." onClick="recordEvent(this, 'Target database links', 'http://gpcrdb.org/protein/gp174_human', 'GPCRdb');return false;">gp174_human</a> (Hs), <a href="http://gpcrdb.org/protein/gp174_mouse" target="_blank" title="Tools for visualising and analysing data on sequence and structure of GPCRs." onClick="recordEvent(this, 'Target database links', 'http://gpcrdb.org/protein/gp174_mouse', 'GPCRdb');return false;">gp174_mouse</a> (Mm) </td> </tr> <tr> <td class="info" colspan="2" style="font-style: italic; font-weight: bold;"> Other databases </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> Alphafold </td> <td class="info embedded_link"> <a href="https://alphafold.ebi.ac.uk/entry/Q9BXC1" target="_blank" title="AlphaFold, a state-of-the-art AI system developed by DeepMind, is able to computationally predict protein structures with unprecedented accuracy and speed. These predictions are being made freely and openly available to the global scientific community in partnership with EMBL’s European Bioinformatics Institute (EMBL-EBI), opening up new and exciting research avenues." onClick="recordEvent(this, 'Target database links', 'https://alphafold.ebi.ac.uk/entry/Q9BXC1', 'Alphafold');return false;">Q9BXC1</a> (Hs), <a href="https://alphafold.ebi.ac.uk/entry/Q3U507" target="_blank" title="AlphaFold, a state-of-the-art AI system developed by DeepMind, is able to computationally predict protein structures with unprecedented accuracy and speed. These predictions are being made freely and openly available to the global scientific community in partnership with EMBL’s European Bioinformatics Institute (EMBL-EBI), opening up new and exciting research avenues." onClick="recordEvent(this, 'Target database links', 'https://alphafold.ebi.ac.uk/entry/Q3U507', 'Alphafold');return false;">Q3U507</a> (Mm) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> ChEMBL Target </td> <td class="info embedded_link"> <a href="https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3562167" target="_blank" title="Database of bioactive drug-like small molecules and targets" onClick="recordEvent(this, 'Target database links', 'https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3562167', 'ChEMBL Target');return false;">CHEMBL3562167</a> (Hs), <a href="https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3813587" target="_blank" title="Database of bioactive drug-like small molecules and targets" onClick="recordEvent(this, 'Target database links', 'https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3813587', 'ChEMBL Target');return false;">CHEMBL3813587</a> (Mm) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> Ensembl Gene </td> <td class="info embedded_link"> <a href="https://www.ensembl.org/Gene/Summary?g=ENSG00000147138" target="_blank" title="Genome database and automatic annotation" onClick="recordEvent(this, 'Target database links', 'https://www.ensembl.org/Gene/Summary?g=ENSG00000147138', 'Ensembl Gene');return false;">ENSG00000147138</a> (Hs), <a href="https://www.ensembl.org/Gene/Summary?g=ENSMUSG00000073008" target="_blank" title="Genome database and automatic annotation" onClick="recordEvent(this, 'Target database links', 'https://www.ensembl.org/Gene/Summary?g=ENSMUSG00000073008', 'Ensembl Gene');return false;">ENSMUSG00000073008</a> (Mm), <a href="https://www.ensembl.org/Gene/Summary?g=ENSRNOG00000032970" target="_blank" title="Genome database and automatic annotation" onClick="recordEvent(this, 'Target database links', 'https://www.ensembl.org/Gene/Summary?g=ENSRNOG00000032970', 'Ensembl Gene');return false;">ENSRNOG00000032970</a> (Rn) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> Entrez Gene </td> <td class="info embedded_link"> <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84636" target="_blank" title="Integrated information for genes from a wide range of species" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84636', 'Entrez Gene');return false;">84636</a> (Hs), <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=213439" target="_blank" title="Integrated information for genes from a wide range of species" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=213439', 'Entrez Gene');return false;">213439</a> (Mm), <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=302373" target="_blank" title="Integrated information for genes from a wide range of species" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=302373', 'Entrez Gene');return false;">302373</a> (Rn) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> Human Protein Atlas </td> <td class="info embedded_link"> <a href="https://www.proteinatlas.org/ENSG00000147138" target="_blank" title="Human tissue expression atlas" onClick="recordEvent(this, 'Target database links', 'https://www.proteinatlas.org/ENSG00000147138', 'Human Protein Atlas');return false;">ENSG00000147138</a> (Hs) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> KEGG Gene </td> <td class="info embedded_link"> <a href="http://www.genome.jp/dbget-bin/www_bget?hsa:84636" target="_blank" title="Kyoto Encyclopedia of Genes and Genomes" onClick="recordEvent(this, 'Target database links', 'http://www.genome.jp/dbget-bin/www_bget?hsa:84636', 'KEGG');return false;">hsa:84636</a> (Hs), <a href="http://www.genome.jp/dbget-bin/www_bget?mmu:213439" target="_blank" title="Kyoto Encyclopedia of Genes and Genomes" onClick="recordEvent(this, 'Target database links', 'http://www.genome.jp/dbget-bin/www_bget?mmu:213439', 'KEGG');return false;">mmu:213439</a> (Mm), <a href="http://www.genome.jp/dbget-bin/www_bget?rno:302373" target="_blank" title="Kyoto Encyclopedia of Genes and Genomes" onClick="recordEvent(this, 'Target database links', 'http://www.genome.jp/dbget-bin/www_bget?rno:302373', 'KEGG');return false;">rno:302373</a> (Rn) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> OMIM </td> <td class="info embedded_link"> <a href="https://www.omim.org/entry/300903" target="_blank" title="Online Mendelian Inheritance in Man: database of human genes and genetic disorders" onClick="recordEvent(this, 'Target database links', 'https://www.omim.org/entry/300903', 'OMIM');return false;">300903</a> (Hs) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> Pharos </td> <td class="info embedded_link"> <a href="https://pharos.nih.gov/targets/Q9BXC1" target="_blank" title="Pharos is the user interface to the Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) program" onClick="recordEvent(this, 'Target database links', 'https://pharos.nih.gov/targets/Q9BXC1', 'Pharos');return false;">Q9BXC1</a> (Hs) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> RefSeq Nucleotide </td> <td class="info embedded_link"> <a href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=NM_032553" target="_blank" title="NCBI Reference Sequence Database" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=NM_032553', 'RefSeq Nucleotide');return false;">NM_032553</a> (Hs), <a href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=NM_001033251" target="_blank" title="NCBI Reference Sequence Database" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=NM_001033251', 'RefSeq Nucleotide');return false;">NM_001033251</a> (Mm), <a href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=NM_001106938" target="_blank" title="NCBI Reference Sequence Database" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=NM_001106938', 'RefSeq Nucleotide');return false;">NM_001106938</a> (Rn) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> RefSeq Protein </td> <td class="info embedded_link"> <a href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115942" target="_blank" title="NCBI Reference Sequence Database" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_115942', 'RefSeq Protein');return false;">NP_115942</a> (Hs), <a href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001028423" target="_blank" title="NCBI Reference Sequence Database" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001028423', 'RefSeq Protein');return false;">NP_001028423</a> (Mm), <a href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001100408" target="_blank" title="NCBI Reference Sequence Database" onClick="recordEvent(this, 'Target database links', 'https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001100408', 'RefSeq Protein');return false;">NP_001100408</a> (Rn) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> UniProtKB </td> <td class="info embedded_link"> <a href="https://www.uniprot.org/uniprot/Q9BXC1" target="_blank" title="Universal Protein Resource catalog of information on proteins" onClick="recordEvent(this, 'Target database links', 'https://www.uniprot.org/uniprot/Q9BXC1', 'UniProtKB');return false;">Q9BXC1</a> (Hs), <a href="https://www.uniprot.org/uniprot/Q3U507" target="_blank" title="Universal Protein Resource catalog of information on proteins" onClick="recordEvent(this, 'Target database links', 'https://www.uniprot.org/uniprot/Q3U507', 'UniProtKB');return false;">Q3U507</a> (Mm) </td> </tr> <tr> <td class="info" style="min-width:200px;max-width:200px;width:200px;"> Wikipedia </td> <td class="info embedded_link"> <a href="https://en.wikipedia.org/wiki/GPR174" target="_blank" title="The Free Encyclopedia" onClick="recordEvent(this, 'Target database links', 'https://en.wikipedia.org/wiki/GPR174', 'Wikipedia');return false;"><i>GPR174</i></a> (Hs) </td> </tr> </table> <a name="Endogenous"></a> <table class="receptor_data_tables fullwidth"> <thead> <tr> <td class="info category">Natural/Endogenous Ligands <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#NaturalLigands', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> </thead> <tbody> <tr class="info"><td> <a href="LigandDisplayForward?ligandId=4064">lysophosphatidylserine</a> </td></tr> <tr class="info"><td ><b>Comments:</b> Proposed ligand, two publications</td></tr> </tbody> </table> <p style="font-size:105%;font-weight:bold;padding:5px 0px;margin-top:20px;border:solid 1px #AAAAAA;text-align:center;"> <a href="SARFileDownload?objectId=145">Download all structure-activity data for this target as a CSV file <img src="images_dev27082012/go.jpg" alt="go icon to follow link"/></a> </p> <a name="Agonists"></a> <table class="receptor_data_tables fullwidth"> <thead> <tr name="hotspot" class="hotspot"> <td class="info category" colspan="3">Agonists </td> </tr> </thead> <tbody name="toggle"> <tr> <td class="table_instructions" style="text-align:left; border-style: solid none solid solid;font-weight:bold;"> <a href="JavaScript:callRef('helpPagePopup.jsp#ligandTables', 800, 620)">Key to terms and symbols</a> </td> <td class="table_instructions" style="text-align:center; border-style: solid none solid none;font-size:105%;font-weight:bold;"> <a href='javascript:newWindow("ObjectInteractionStructuresDisplayForward?objectId=145&familyId=16&type=Agonists", 960, 800)'> View all chemical structures</a> </td> <td class="table_instructions" style="border-style: solid solid solid none;text-align:right;"> Click column headers to sort </td> </tr> <tr> <td class="table_container" colspan="3"> <table id="agonists" class = "tablesorter inner_receptor_data_tables" > <thead> <tr class="info heading"> <th class="ligand_header header" style="border-style:solid none solid solid;">Ligand</th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid none solid none;"></th> <th class="tablesorter-noSort" style="border-style:solid solid solid none;"></th> <th class="keybox_header header">Sp.</th> <th class="action_header header">Action</th> <th class="value_header header">Value</th> <th class="units_header header">Parameter</th> <th class="reference_header header">Reference</th> <th class="tablesorter-noSort"></th> </tr> </thead> <tbody> <tr class="info"> <td style="border-style: solid dotted none solid;" rowspan="1"> <a href="LigandDisplayForward?ligandId=4064"> lysophosphatidylserine </a> </td> <td style="border-style: solid none solid dotted;padding:1px;width:20px;text-align:center;"> <a style="color:white;" title="Small molecule or natural product"> <img src="images/benzene.gif" alt="Small molecule or natural product"/> </a> </td> <td style="border-style: solid none solid none;padding:1px;width:20px;text-align:center;"> </td> <td style="border-style: solid none solid none;padding:1px;width:20px;text-align:center;"> </td> <td style="border-style: solid none solid none;padding:1px;width:20px;text-align:center;"> <a style="color:white;" href='javascript:callRef("LigandInteractionsDisplayForward?ligandId=4064&species=Human", 700, 700)' title="Click here for species-specific activity table"> <img src="images/select.gif" alt="Click here for species-specific activity table"/> </a> </td> <td style="border-style: solid none solid none;padding:1px;width:20px;text-align:center;"> <a style="color:white;" title="Ligand is endogenous in the given species"> <img src="images/endog.gif" alt="Ligand is endogenous in the given species"/> </a> </td> <td style="border-style: solid none solid none;padding:1px;width:20px;text-align:center;"> </td> <td style="border-style: solid none solid none;padding:1px;width:26px;text-align:center;"> </td> <td style="border-style: solid none solid none;padding:1px;width:22px;text-align:center;"> </td> <td style="border-style: solid none solid none;padding:1px;width:22px;text-align:center;"> </td> <td style="border-style: solid solid solid none;padding:1px;width:22px;text-align:center;"> </td> <td style="text-align:center;"><a style="color:black;" title="Human">Hs</a></td> <td>Full agonist</td> <td> 7.1 </td> <td> pEC<sub>50</sub> </td> <td> <a href='javascript:callRef("ReferenceDisplayForward?referenceId=19451&displayId=2", 960, 600)' title="2. Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K et al.. (2012) Nat Methods. 9 (10): 1021-9">2</a> </td> <td> <a name="rawdata" title="all interaction assay details and raw data" class="toggle"><div class="arrow"></div></a> </td> </tr> <tr class="tablesorter-childRow info"> <td style="border-style: solid dotted solid solid; text-align:right; vertical-align: top;"><b style="font-size: x-large;">&#10551</b></td> <td colspan="14"> pEC<sub>50</sub> 7.1 (EC<sub>50</sub> 8.1x10<sup>-8</sup> M) [<a href='javascript:callRef("ReferenceDisplayForward?referenceId=19451&displayId=2", 960, 600)' title="2. Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K et al.. (2012) Nat Methods. 9 (10): 1021-9">2</a>] </td> </tr> </tbody> </table> </td> </tr> <tr> <td class="info category" colspan="3"> Agonist Comments</td> </tr> <tr> <td class="info" colspan="3"> GPR174 has been shown to be activated by lysophosphatidylserine, with coupling to cAMP and ERK [<a href='javascript:callRef("ReferenceDisplayForward?referenceId=19451&displayId=2", 960, 600)' title="2. Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K et al.. (2012) Nat Methods. 9 (10): 1021-9">2</a>,<a href='javascript:callRef("ReferenceDisplayForward?referenceId=19450&displayId=4", 960, 600)' title="4. Sugita K, Yamamura C, Tabata K, Fujita N. (2013) Biochem Biophys Res Commun. 430 (1): 190-5">4</a>].</td> </tr> </tbody> </table> <script type="text/javascript"> $(function(){ $("#agonists").tablesorter(); }); </script> <a name="Processes"></a> <table class="receptor_data_tables fullwidth"> <tr name="hotspot" class="hotspot"> <td class="info category">Immuno Process Associations</td> </tr> <tr> <td class="info"> <table class="inner_receptor_data_tables" style="width:70%;"> <tr> <td class="key">Immuno Process: </td> <td class="value"><a href="ObjectImmProcessListForward?immprocess=6">Immune regulation</a></td> </tr> </table> </td> </tr> </table> <a name="Transductions"></a> <a name="Expression"></a> <table class="receptor_data_tables fullwidth"> <thead> <tr name="hotspot" class="hotspot"> <td class="info category">Expression Datasets <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#expDatasets', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> </thead> <tbody name="toggle"> <tr> <td class="info"> <table class="inner_receptor_data_tables"> <tr> <td class="description"> <p style="text-align:left;"> <a id="show_expGraphs" href="javascript:toggleLayerAndLink('expGraphs', 'show_expGraphs', 'hide_expGraphs');"><small>Show</small> »</a><a id="hide_expGraphs" style="display:none;" href="javascript:toggleLayerAndLink('expGraphs', 'show_expGraphs', 'hide_expGraphs');">« <small>Hide</small></a> </p> <div id="expGraphs"> <p style="text-align:left;margin-top:10px;">Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. <i>Cell</i>, <b>135</b>(3): 561-71. [PMID:<a href="http://www.ncbi.nlm.nih.gov/pubmed/18984166" target="_blank">18984166</a>] [Raw data: <a href="https://kidbdev.med.unc.edu/databases/ShaunCell/home.php" target="_blank">website</a>]</p> <div id="highchart1" style=" width: 910px; height: 400px; margin-top:10px;">There should be a chart of expression data here, you may need to enable JavaScript!</div> <script type="text/javascript"> var chart1 = new Highcharts.Chart({ chart: { renderTo: 'highchart1', defaultSeriesType: 'column', margin: [50, 50, 150, 80] }, title: { text: 'Log average relative transcript abundance for Gpr174 in mouse tissues' }, xAxis: { categories: ['Olfactory epithelium', 'Brainstem', 'Cerebellum', 'Cerebral cortex', 'Hippocampus', 'Hypothalamus', 'Olfactory bulb', 'Pituitary gland', 'Striatum', 'Retina', 'Whole eye', 'Adrenal gland', 'Islet', 'Thyroid/Parathyroid', 'Aorta', 'Vena cava', 'Heart atrium', 'Heart ventricle', 'Lung', 'Trachea', 'Brown adipose', 'Kidney', 'Liver', 'Skeletal muscle', 'White adipose', 'Adipocyte', 'Tongue', 'Esophagus', 'Gall bladder', 'Large intestine', 'Pancreas', 'Small intestine', 'Stomach', 'Urinary bladder', 'Spleen', 'Thymus', 'Bone marrow', 'Ovary', 'Testes', 'Uterus', 'Skin'], labels: { rotation: -90, align: 'right', style: { font: 'normal 12px Verdana, sans-serif', color: '#000000' } } }, yAxis: { title: { min: 0, text: 'Log average relative abundance' }, labels: { style: { color: '#000000' } } }, legend: { enabled: false }, tooltip: { formatter: function() { return '<b>'+ this.x +'</b><br/>'+ 'Log average relative abundance: '+ Highcharts.numberFormat(this.y, 2); } }, series: [{ name: 'Tissues', data: [0.26, 0, 0, 0, 0.07, 0.16, 0.7, 0, 0, 0, 0, 0, 0.45, 0.01, 0, 0.16, 0.1, 0.05, 1.18, 0, 0.01, 0.03, 0.04, 0, 0.21, 0.08, 0, 0, 0.05, 0.77, 0.03, 0.4, 0, 0.03, 2.23, 1.91, 1.34, 0.12, 0, 0.37, 0.13] }] }); </script> </div> </td> </tr> </table> </td> </tr> </tbody> </table> <a name="Mutations"></a> <table class="receptor_data_tables fullwidth"> <thead> <tr name="hotspot" class="hotspot"> <td class="info category">Clinically-Relevant Mutations and Pathophysiology <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#mutation', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a> </td> </tr> </thead> <tbody name="toggle"> <tr> <td class="info"> <table class="inner_receptor_data_tables"> <tr> <td class="info" colspan="4"> <table class="inner_receptor_data_tables"> <tr> <td class="key">Disease: </td> <td class="value"> <b><a href="DiseaseDisplayForward?diseaseId=405">Graves' disease</a></b> <table class="inner_data_table disease_detail"> <tr> <td>Disease Ontology:</td> <td><a href="http://purl.obolibrary.org/obo/DOID_12361" target="_blank" title="A standardised ontology for human disease and medical vocabularies" onClick="recordEvent(this, 'Disease database links', 'http://purl.obolibrary.org/obo/DOID_12361', 'Disease Ontology');return false;">DOID:12361</a></td> </tr> </table> </td> </tr> <tr> <td class="key">References: </td> <td class="value"><a href='javascript:callRef("ReferenceDisplayForward?referenceId=21103&displayId=1", 960, 600)' title="1. Chu X, Shen M, Xie F, Miao XJ, Shou WH, Liu L, Yang PP, Bai YN, Zhang KY, Yang L et al.. (2013) J Med Genet. 50 (7): 479-85">1</a>,<a href='javascript:callRef("ReferenceDisplayForward?referenceId=21104&displayId=5", 960, 600)' title="5. Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, Zhan M, Wang HN, Liang J, Gao GQ et al.. (2013) Hum Mol Genet. 22 (16): 3347-62">5</a></td> </tr> </table> </td> </tr> </table> </td> </tr> </tbody> </table> <a name="GeneExpressionPathophysiology"></a> <table class="receptor_data_tables fullwidth"> <tbody name="toggle"> <tr> <td class="info category" colspan="2"> Gene Expression and Pathophysiology Comments</td> </tr> <tr> <td class="info" colspan="2"> <i>GPR174</i> was found to be overexpressed in subcutaneous melanomametastases [<a href='javascript:callRef("ReferenceDisplayForward?referenceId=11945&displayId=3", 960, 600)' title="3. Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. (2011) Pigment Cell Melanoma Res. 24 (1): 207-18">3</a>].</td> </tr> </tbody> </table> <a name="variants"></a> <table class="receptor_data_tables fullwidth"> <thead> <tr name="hotspot" class="hotspot"> <td class="info category" >Biologically Significant Variants <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#variants', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a> </td> </tr> </thead> <tbody name="toggle"> <tr> <td class="info"> <table class="inner_receptor_data_tables"> <tr> <td class="key">Type: </td> <td class="value">Single nucleotide polymorphism</td> </tr> <tr> <td class="key">Species: </td> <td class="value">Human</td> </tr> <tr> <td class="key">Description: </td> <td class="description">Amino acid change associated with risk for Graves' disease</td> </tr> <tr> <td class="key">Amino acid change: </td> <td class="value">S162P</td> </tr> <tr> <td class="key">Nucleotide change: </td> <td class="value">519C>T</td> </tr> <tr> <td class="key">Global MAF (%): </td> <td class="value">49</td> </tr> <tr> <td class="key">Subpopulation MAF (%): </td> <td class="value">AFR|AMR|ASN|EUR: 37|41|46|62</td> </tr> <tr> <td class="key">Minor allele count: </td> <td class="value">C=0.489/811</td> </tr> <tr> <td class="key">SNP accession: </td> <td class="value embedded_link"> <a href="http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=rs3827440">rs3827440</a> </td> </tr> <tr> <td class="key">Validation: </td> <td class="value">1000 Genomes, HapMap, Frequency</td> </tr> <tr> <td class="key">References: </td> <td class="value"><a href='javascript:callRef("ReferenceDisplayForward?referenceId=21103&displayId=1", 960, 600)' title="1. Chu X, Shen M, Xie F, Miao XJ, Shou WH, Liu L, Yang PP, Bai YN, Zhang KY, Yang L et al.. (2013) J Med Genet. 50 (7): 479-85">1</a></td> </tr> </table> </td> </tr> <tr> <td class="info"> <table class="inner_receptor_data_tables"> <tr> <td class="key">Type: </td> <td class="value">Single nucleotide polymorphism</td> </tr> <tr> <td class="key">Species: </td> <td class="value">Human</td> </tr> <tr> <td class="key">Description: </td> <td class="description">Nucleotide transition A>C at location X:78497118 associated with risk for Graves' disease. No amino acid change reported.</td> </tr> <tr> <td class="key">Global MAF (%): </td> <td class="value">0.49</td> </tr> <tr> <td class="key">Subpopulation MAF (%): </td> <td class="value">AFR|AMR|ASN|EUR: 40|41|43|62</td> </tr> <tr> <td class="key">Minor allele count: </td> <td class="value">C=0.485/802</td> </tr> <tr> <td class="key">SNP accession: </td> <td class="value embedded_link"> <a href="http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=rs5912838">rs5912838</a> </td> </tr> <tr> <td class="key">Validation: </td> <td class="value">1000 Genomes, HapMap, Frequency</td> </tr> <tr> <td class="key">References: </td> <td class="value"><a href='javascript:callRef("ReferenceDisplayForward?referenceId=21104&displayId=5", 960, 600)' title="5. Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, Zhan M, Wang HN, Liang J, Gao GQ et al.. (2013) Hum Mol Genet. 22 (16): 3347-62">5</a></td> </tr> </table> </td> </tr> <tr> <td class="info category">Biologically Significant Variant Comments</td> </tr> <tr> <td class="info"> A number of rare single nucleotide polymorphisms are reported by Chu <i>et al.</i> in their genome-wide assocation study as being associated with Graves' disease. However, with the exception of rs3827440, none of these variants occured at a frequency of more than 5% in the population studied [<a href='javascript:callRef("ReferenceDisplayForward?referenceId=21103&displayId=1", 960, 600)' title="1. Chu X, Shen M, Xie F, Miao XJ, Shou WH, Liu L, Yang PP, Bai YN, Zhang KY, Yang L et al.. (2013) J Med Genet. 50 (7): 479-85">1</a>].</td> </tr> </tbody> </table> </div>  </div> </div>   <div class="grid_16 alpha"> <h4><a name="references"></a>References</h4> <div class="contentboxfullhelp"> <div class="textright"> <p > <a id="show_refs" href="javascript:toggleLayerAndLink('refs', 'show_refs', 'hide_refs');"><small>Show</small> »</a><a id="hide_refs" style="display:none;" href="javascript:toggleLayerAndLink('refs', 'show_refs', 'hide_refs');">« <small>Hide</small></a> </p> <div id="refs"> <p > 1. Chu X, Shen M, Xie F, Miao XJ, Shou WH, Liu L, Yang PP, Bai YN, Zhang KY, Yang L <i>et al.</i>. (2013) An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease. <i>J Med Genet</i>, <b>50</b> (7): 479-85. [PMID:<a href="javascript:newWindow('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=23667180', 800, 500)">23667180</a>] </p> <p > 2. Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K <i>et al.</i>. (2012) TGFα shedding assay: an accurate and versatile method for detecting GPCR activation. <i>Nat Methods</i>, <b>9</b> (10): 1021-9. [PMID:<a href="javascript:newWindow('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=22983457', 800, 500)">22983457</a>] </p> <p > 3. Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. (2011) Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. <i>Pigment Cell Melanoma Res</i>, <b>24</b> (1): 207-18. [PMID:<a href="javascript:newWindow('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=20880198', 800, 500)">20880198</a>] </p> <p > 4. Sugita K, Yamamura C, Tabata K, Fujita N. (2013) Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP. <i>Biochem Biophys Res Commun</i>, <b>430</b> (1): 190-5. [PMID:<a href="javascript:newWindow('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=23178570', 800, 500)">23178570</a>] </p> <p > 5. Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, Zhan M, Wang HN, Liang J, Gao GQ <i>et al.</i>. (2013) Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. <i>Hum Mol Genet</i>, <b>22</b> (16): 3347-62. [PMID:<a href="javascript:newWindow('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=23612905', 800, 500)">23612905</a>] </p> </div> </div> </div> </div>   <div class="grid_16 alpha"> <a name="Contributors"></a> <h4>Contributors</h4> <div class="contentboxfullhelp"> <div class="textright"> <p> <a id="145_show_contributors" class="hiddenSection" href="javascript:toggleLayerAndLink('145_contributors', '145_show_contributors', '145_hide_contributors');"><small>Show</small> »</a><a id="145_hide_contributors" class="visibleSection" style="display:none;" href="javascript:toggleLayerAndLink('145_contributors', '145_show_contributors', '145_hide_contributors');">« <small>Hide</small></a> </p> <div id="145_contributors" class="visibleSection" style="display:none;"> <table> <tr> <td style="vertical-align: top;"> <h3>Contributors:</h3> <p> <b><a href="ContributorDisplayForward?contributorId=532">Stephen P.H. Alexander</a></b><br/> Associate Professor in Molecular Pharmacology<br/>Life Sciences E Floor<br/>University of Nottingham Medical School<br/>Nottingham NG7 2UH<br/>UK </p> <p> <b><a href="ContributorDisplayForward?contributorId=75">Jim Battey</a> (BB<sub>3</sub>)</b><br/> National Institute on Deafness and Other Communication Disorders<br/>Building 31 Room 3C02<br/>NIH<br/>Bethesda<br/>MD<br/>20892<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=554">Helen E. Benson</a></b><br/> <i>(Past curator)</i><br/> Centre for Discovery Brain Sciences<br/>Edinburgh Medical School: Biomedical Sciences<br/>Room 338<br/>Hugh Robson Building<br/>George Square<br/>Edinburgh<br/>EH8 9XD<br/>UK </p> <p> <b><a href="ContributorDisplayForward?contributorId=76">Richard V. Benya</a> (BB<sub>3</sub>)</b><br/> University of Illinois<br/>Section of Digestive Diseases and Nutrition<br/>840 South Wood Street (M/C 716)<br/>Chicago<br/>Illinois<br/>60612<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=344">Tom I. Bonner</a></b><br/> Special Volunteer<br/>Office of Science Director<br/>NIMH<br/>Bethesda<br/>MD<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=71">Anthony P. Davenport</a></b><br/> Experimental Medicine and Immunotherapeutics<br>University of Cambridge<br>Addenbrooke’s Hospital<br>Cambridge<br>UK </p> <p> <b><a href="ContributorDisplayForward?contributorId=958">Khuraijam Dhanachandra Singh</a></b><br/> Department of Molecular Cardiology<br/>Lerner Research Institute<br/>The Cleveland Clinic Foundation<br/>9500 Euclid Ave.<br/>Cleveland, OH 44195<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=716">Satoru Eguchi</a></b><br/> Cardiovascular Research Center<br/>Temple University School of Medicine<br/>3500 N Broad Street<br/>Philadelphia<br/>PA 19140<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=369">Anthony Harmar</a></b><br/> <i>(1951-2014)</i><br/> formerly of the University of Edinburgh, Edinburgh, Scotland </p> <p> <b><a href="ContributorDisplayForward?contributorId=836">Nick Holliday</a></b><br/> Room CS6 The Medical School, Floor C<br/>Queen's Medical Centre<br/>Nottingham NG7 2UH<br/>UK </p> <p> <b><a href="ContributorDisplayForward?contributorId=74">Robert T. Jensen</a> (BB<sub>3</sub>)</b><br/> National Institute of Diabetes & Kidney Diseases<br/>National Institutes of Health<br/>Building 10 Room 9C-103<br/>NIH<br/>Bethesda<br/>MD<br/>20892<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=598">Sadashiva Karnik</a> (<i>MAS1</i>)</b><br/> Department of Molecular Cardiology<br/>Lerner Research Institute<br/>The Cleveland Clinic Foundation<br/>9500 Euclid Ave.<br/>Cleveland, OH 44195<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=708">Evi Kostenis</a> (<i>GPR17</i>)</b><br/> Section Molecular, Cellular and Pharmacobiology<br/>Institute for Pharmaceutical Biology<br/>University of Bonn<br/>Nussallee 6<br/>53115 Bonn<br/>Germany </p> <p> <b><a href="ContributorDisplayForward?contributorId=584">Wen Chiy Liew</a></b><br/> <i>(Past curator)</i><br/> </p> <p> <b><a href="ContributorDisplayForward?contributorId=585">Amy E. Monaghan</a></b><br/> <i>(Past curator)</i><br/> </p> <p> <b><a href="ContributorDisplayForward?contributorId=459">Chido Mpamhanga</a></b><br/> <i>(Past curator)</i><br/> </p> <p> <b><a href="ContributorDisplayForward?contributorId=562">Richard Neubig</a></b><br/> Michigan State University<br/>1355 Bogue St<br/>B440 Life Sciences Building<br/>East Lansing<br/>MI 48824 </p> <p> <b><a href="ContributorDisplayForward?contributorId=586">Adam J Pawson</a></b><br/> <i>(Past Senior Database Curator)</i><br/> Centre for Discovery Brain Sciences<br/>Edinburgh Medical School: Biomedical Sciences<br/>Room 338, Hugh Robson Building<br/>George Square<br/>Edinburgh, EH8 9XD </p> <p> <b><a href="ContributorDisplayForward?contributorId=158">Jean-Philippe Pin</a></b><br/> Institut de Génomique Fonctionnelle<br/>UMR 5203 CNRS – U 1191 INSERM – Univ. Montpellier<br/>141<br/>rue de la cardonille<br/>34094 Montpellier Cedex 05 - France </p> <p> <b><a href="ContributorDisplayForward?contributorId=662">Joanna L. Sharman</a></b><br/> <i>(Past senior developer)</i><br/> Centre for Discovery Brain Sciences<br/>Edinburgh Medical School: Biomedical Sciences<br/>Room 338<br/>Hugh Robson Building<br/>George Square<br/>Edinburgh<br/>EH8 9XD<br/>UK </p> <p> <b><a href="ContributorDisplayForward?contributorId=521">Michael Spedding</a></b><br/> Spedding Research Solutions SARL<br/>6 Rue Ampere<br/>Le Vesinet<br/>78110<br/>France </p> <p> <b><a href="ContributorDisplayForward?contributorId=77">Eliot Spindel</a> (BB<sub>3</sub>)</b><br/> Oregon National Primate Research Center Division of Neuroscience<br/>3181 SW Sam Jackson Park Road<br/>Portland<br/>OR<br/>97239<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=146">Leigh Stoddart</a></b><br/> Division of Biochemistry and Molecular Biology<br/>Institute of Biomedical and Life Sciences<br/>University of Glasgow<br/>Glasgow G12 8QQ<br/>UK </p> <p> <b><a href="ContributorDisplayForward?contributorId=457">Laura Storjohann</a> (<i>GPR39</i>)</b><br/> Salt Lake City<br/>UT 84124 </p> <p> <b><a href="ContributorDisplayForward?contributorId=560">Walter G. Thomas</a></b><br/> School of Biomedical Sciences<br/>The University of Queensland<br/>BNE, QUEENSLAND 4072<br/>Australia </p> <p> <b><a href="ContributorDisplayForward?contributorId=714">Kalyan Tirupula</a> (<i>MAS1</i>)</b><br/> Department of Molecular Cardiology<br/>Lerner Research Institute<br/>The Cleveland Clinic Foundation<br/>9500 Euclid Ave.<br/>Cleveland, OH 44195<br/>USA </p> <p> <b><a href="ContributorDisplayForward?contributorId=715">Patrick Vanderheyden</a></b><br/> Department of Molecular and Biochemical Pharmacology<br/>Vrije Universiteit Brussel<br/>Pleinlaan 2<br/>1050, Brussels<br/>Belgium </p> </td> </tr> </table> </div> </div> </div> </div>   <div class="grid_16 alpha"> <h4><a name="citing"></a>How to cite this page</h4> <div class="contentboxfullhelp"> <div class="textright">  <p> <label for="citationOptions">Select citation format:</label><select id="citationOptions" onchange="displayCitation(i)"> <option value="vancouver" selected="selected">Vancouver</option> <option value="harvard">Harvard</option> <option value="acm">ACM</option> <option value="bibtex">BibTeX</option> <option value="ris">RIS</option> </select> <p id="citation"></p> <p id="citation2"></p> <script> var v1 = { "volume": "2023", "number": "1", "doi": "10.2218/gtopdb/F16/2023.1", "authlist": [ { "lastname": "Alexander", "firstnames": "Stephen P.H." }, { "lastname": "Battey", "firstnames": "Jim" }, { "lastname": "Benson", "firstnames": "Helen E." }, { "lastname": "Benya", "firstnames": "Richard V." }, { "lastname": "Bonner", "firstnames": "Tom I." }, { "lastname": "Davenport", "firstnames": "Anthony P." }, { "lastname": "Dhanachandra Singh", "firstnames": "Khuraijam" }, { "lastname": "Eguchi", "firstnames": "Satoru" }, { "lastname": "Harmar", "firstnames": "Anthony" }, { "lastname": "Holliday", "firstnames": "Nick" }, { "lastname": "Jensen", "firstnames": "Robert T." }, { "lastname": "Karnik", "firstnames": "Sadashiva" }, { "lastname": "Kostenis", "firstnames": "Evi" }, { "lastname": "Liew", "firstnames": "Wen Chiy" }, { "lastname": "Monaghan", "firstnames": "Amy E." }, { "lastname": "Mpamhanga", "firstnames": "Chido" }, { "lastname": "Neubig", "firstnames": "Richard" }, { "lastname": "Pawson", "firstnames": "Adam J" }, { "lastname": "Pin", "firstnames": "Jean-Philippe" }, { "lastname": "Sharman", "firstnames": "Joanna L." }, { "lastname": "Spedding", "firstnames": "Michael" }, { "lastname": "Spindel", "firstnames": "Eliot" }, { "lastname": "Stoddart", "firstnames": "Leigh" }, { "lastname": "Storjohann", "firstnames": "Laura" }, { "lastname": "Thomas", "firstnames": "Walter G." }, { "lastname": "Tirupula", "firstnames": "Kalyan" }, { "lastname": "Vanderheyden", "firstnames": "Patrick" } ], "key": "GtoPdbCITE/2023.1/F16", "year": "2023", "journal": "IUPHAR/BPS Guide to Pharmacology CITE", "title": "Class A Orphans in GtoPdb v.2023.1", "issue": "2023 (1)", "month": "Apr", }; 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