HCV Updates and Case Challenges for the Rapidly Changing Landscape

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Highly effective direct-acting antivirals (DAAs) and additional ones in development offer favorable safety profiles and high cure rates for most patients. Certain populations, however, pose a significant challenge to treatment success. 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<div class="page-title desktop-view"> <h1>HCV Updates and Case Challenges for the Rapidly Changing Landscape</h1> </div> <div class="page-title mobile-view"> <h1>HCV Updates and Case Challenges for the Rapidly Changing Landscape</h1> <p class="support-info">This activity is supported by an educational grant from Merck & Co., Inc.</p> </div> <div class="content-wrap edlab-content theme"> <p class="trigger-link pull-right"><a href="#"><i class="fa fa-info-circle"></i> <span class="small">CME Information</span></a></p><script type="text/javascript">$j('#buttonShowOverview, .trigger-link a').click(function() { $j('#dripReg1').hide(); $j('#overviewTable').show(); $j('.modal-title').html('HCV Updates and Case Challenges for the Rapidly Changing Landscape'); if (!$j('#btnPrintModal').length) { $j('div.modal-footer button.btn').before('<input type="button" class="btn btn-primary" id="btnPrintModal" text="Print" value="Print" />'); } $j('#modal').modal(); 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desktop-view"> <input type="submit" name="main_0$ctl01$ctl01$ctl00" value="Take the CME Test 禄" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("main_0$ctl01$ctl01$ctl00", "", false, "", "/gastroenterology/education-lab/2016/06_june/hcv-updates-and-case-challenges-for-the-rapidly-changing-landscape/posttest", false, false))" class="btn btn-primary btn-xs posttest-btn theme"> </p> </div> <h2>Overview</h2> <div id="main_0_ctl01_ctl01_divContentWrapper" class="row cme-information"> <a name="ContentTop" id="ContentTop"></a> <a name="content"></a> <table id="overviewTablePage"><tr><td colspan="2"><b>Author(s)/Faculty: </b>Nancy Reau, MD, FAASLD, AGAF; Brian L. Pearlman, MD; Paul Y. Kwo, MD; Hashem B El-Serag, MD, MPH</td></tr><tr><td colspan="2"><b>Source: </b> Healio - Gastroenterology Education Lab</td></tr><tr><td><b>Type: </b> Lecture</td><td><b>Articles/Items: </b> 8</td></tr><tr><td><b>Release Date: </b> 8/5/2016</td><td><b>Expiration Date: </b> 8/4/2017</td></tr><tr><td><b>Credit Type: </b> CME</td><td><b>Number of Credits: </b> 2</td></tr><tr><td><b>Cost: </b> Free</td><td><b>Provider: </b> <img src="https://web.archive.org/web/20160810174822im_/http://m3.wyanokecdn.com/88ebc903c653b05908b5355db24dd21f.gif?h=19&la=en&w=77" alt="Vindico Medical Education" width="77" height="19"></td></tr><tr><td colspan="2" class="intro">In the past few years, significant progress has been made in the treatment of chronic hepatitis C virus (HCV). Highly effective direct-acting antivirals (DAAs) and additional ones in development offer favorable safety profiles and high cure rates for most patients. Certain populations, however, pose a significant challenge to treatment success. These difficult-to-treat patients require clinicians to continually update their knowledge about the various HCV therapies and management strategies. During this program, expert faculty will discuss the latest advances in HCV therapy and strategies to optimize outcomes for populations that remain at risk for treatment failure. 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Please login or <a href="#" onClick="showDripRegistrationForm()">register</a>.'); } function showDripRegistrationForm() { if (window.ga) { ga('send', 'event', 'Drip Registration', 'Education Lab Drip Registration', 'Prompt Short Registration', 0, { 'nonInteraction': true }); } $j("#dripfirstname").show(); $j("#driplastname").show(); $j('label[for="dripfirstname"]').show(); $j('label[for="driplastname"]').show(); $j('#dripsubmit1').show(); $j('label[for="drippassword"]').hide(); $j("#drippassword").hide(); $j('#driplogin').hide(); $j('.remember').hide(); $j("#validationSummary").html(''); $j('.modal-title').text('Register'); $j('.drip-reg-message').html('In order to take the test and claim your CME certificate you must <a href="#" onClick="showLoginForm()" style="text-decoration:underline;">login</a> or register now.'); } </script>  <div id="dripReg1"> <p class="drip-reg-message">In order to take the test and claim your CME certificate you must <a href="#" onclick="showLoginForm()" style="text-decoration:underline;">login</a> or register now.</p> <p id="validationSummary"> <p id="row1"> <label for="dripfirstname">First Name:</label> <input type="text" tabindex="1" id="dripfirstname" name="dripfirstname"> </p> <p id="row2"> <label for="driplastname">Last Name:</label> <input type="text" tabindex="2" id="driplastname" name="driplastname"> </p> <h3 id="formHeader" style="display: none;">Log in</h3> <p id="row3"> <label for="dripemail">Email:</label> <input type="text" tabindex="3" id="dripemail" name="dripemail"> <input type="button" class="btn input_submit" tabindex="3" id="driplogin" value="Log In" name="driplogin" style="display: none;"> </p> <p id="row4"> <label for="drippassword" style="display: none;">Password:</label> <input type="password" tabindex="2" id="drippassword" name="drippassword" style="display: none;"> </p> <p> <input type="button" class="modal-form-btn input_submit" tabindex="3" id="dripsubmit1" value="Submit" name="dripsubmit1"> <img class="loading" style="display: none; position:relative; left: 100px;" src="https://web.archive.org/web/20160810174822im_/http://i3.wyanokecdn.com/ajax-loader.gif" alt="Loading..."> </p> <p class="remember" style="display: none;"> <a href="/web/20160810174822/http://www.healio.com/footer/account-information/login/forgot-password" rel="nofollow" id="layout_1_maincontent_0_ForgotPassword">Forgot Password</a>  |  <a class="help-link" href="/web/20160810174822/http://www.healio.com/login-help">Help</a> </p> <p class="becomemember"> </div> <div id="overviewTable"><p><strong>CME Information</strong></p><p><strong><span style="text-decoration: underline;">Provider Statement:</span></strong><strong> </strong>This continuing medical education activity is provided by <img width="77" height="19" alt="Vindico Medical Education" src="https://web.archive.org/web/20160810174822im_/http://m3.wyanokecdn.com/88ebc903c653b05908b5355db24dd21f.gif">.<strong><span style="text-decoration: underline;"> </span></strong></p> <p><strong><span style="text-decoration: underline;">Support Statement:</span></strong> This activity is supported by an educational grant from Merck & Co., Inc. </p> <p><strong><span style="text-decoration: underline;">Target Audience:</span></strong> The intended audience for the activity is gastroenterologists and other health care professionals involved in the treatment of patients with HCV.</p> <p><strong><span style="text-decoration: underline;">Learning Objectives:</span></strong> Upon successful completion of this educational activity, participants should be better able to:</p> <ul> <li>Review the efficacies, indications and safety profiles of new and emerging direct-acting antiviral combinations for the treatment of HCV. </li> <li>Assess factors that may lead to treatment failure in patients receiving direct-acting antiviral combinations. </li> <li>Apply expert guidance and recent clinical trial data to optimize treatment outcomes for patients with HCV.</li> <li>Integrate guideline recommendations and clinical data of HCV treatments into patient management plans.</li> </ul> <p><strong><span style="text-decoration: underline;">Activity Chair:</span></strong><br> <strong>Nancy Reau MD, FAASLD, AGAF </strong><br> Associate Director of Solid Organ Transplantation Section Chief <br> Hepatology <br> Rush University Medical Center<br> <em>Chicago, IL</em></p> <p><strong><span style="text-decoration: underline;">Faculty:</span></strong><br> <strong>Brian L. Pearlman, MD</strong><br> Medical Director, Center for Hepatitis C<br> Atlanta Medical Center <br> Professor of Medicine <br> Medical College of Georgia <br> Associate Professor of Medicine <br> Emory School of Medicine <br> <em>Atlanta, GA</em> </p> <p><strong>Paul Y. Kwo, MD </strong><br> Professor of Medicine, Medical Director, Liver Transplantation<br> Gastroenterology/Hepatology Division <br> Indiana University School of Medicine <br> <em>Indianapolis, IN</em> </p> <p><strong>Hashem B El-Serag MD, MPH</strong><br> Dan L. Duncan Professor of Medicine<br> Chief, Gastroenterology and Hepatology Section<br> Houston VA Medical Center and Baylor College of Medicine <br> <em>Houston, TX</em> </p> <p><strong><span style="text-decoration: underline;">Peer Reviewer:</span></strong><br> <strong>Joseph K. Lim, MD </strong></p> <p><strong><span style="text-decoration: underline;">Accreditation:</span></strong><br> Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.</p> <p><strong><span style="text-decoration: underline;">Credit Designation:</span></strong><br> Vindico Medical Education designates this enduring material for a maximum of 2.0 <em>AMA PRA Category 1 Credit(s)</em>™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.</p> <p>This enduring material is approved for 1 year from the date of original release, August 5, 2016 through August 4, 2017.</p> <p><strong><span style="text-decoration: underline;">How To Participate in this Activity and Obtain CME Credit:</span></strong><br> To participate in this CME activity, you must read the objectives, answer the pretest questions, watch the presentations, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 80% posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an <em>AMA PRA Category 1 Credit(s)</em>™ Certificate.</p> <p><strong><span style="text-decoration: underline;">Disclosures:</span></strong><br> In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the <strong>relevant financial relationships</strong> of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. </p> <p>The authors disclose that they do have significant financial interests in any products or class of products discussed directly or indirectly in this activity, including research support.</p> <p><span style="text-decoration: underline;">Planning Committee and Faculty Members report the following relationship(s):</span><br> <strong>Nancy Reau MD, FAASLD, AGAF</strong><br> <em>Consulting Fees:</em> AbbVie, Bristol-Myers Squibb, Gilead, Intercept, Merck</p> <p><strong>Brian L. Pearlman, MD </strong><br> <em>Consulting Fee:</em> AbbVie, Gilead, J&J, Merck<br> <em>Contracted Research</em>: AbbVie, Bristol-Myers Squibb, Gilead, J&J, Merck </p> <p><strong>Paul Y. Kwo, MD</strong><br> <em>Consulting Fee:</em> Abbott, AbbVie, Bristol-Myers Squibb, Gilead, Janssen, Merck<br> <em>Contracted Research:</em> AbbVie, Bristol-Myers Squibb, Gilead, Janssen, Merck</p> <p><strong>Hashem B El-Serag MD, MPH </strong><br> <em>Contracted Research: </em>Gilead, Merck, Wako</p> <p><span style="text-decoration: underline;">Peer Reviewer reports the following relationship(s):</span><br> <strong>Joseph K. Lim, MD</strong><br> <em>Consulting Fee:</em> Bristol-Myers Squibb, Gilead <br> <em>Contracted Research:</em> Bristol-Myers Squibb, Gilead </p> <p><span style="text-decoration: underline;">Vindico Medical Education staff report the following relationship(s):</span><br> No relevant financial relationships to disclose.</p> <p>Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.</p> <p><strong><span style="text-decoration: underline;">Unlabeled and Investigational Usage:</span></strong><br> The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.</p> <p><strong><span style="text-decoration: underline;">Copyright Statement:</span></strong><br> Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2016 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.</p> <p><strong><span style="text-decoration: underline;">CME Questions?</span></strong><br> Contact us at <a href="https://web.archive.org/web/20160810174822/mailto:cme@vindicoCME.com">cme@vindicoCME.com</a><strong><span style="text-decoration: underline;"> </span></strong></p></div> </div> <div class="modal-footer"> <button class="btn" data-dismiss="modal"><i class="fa fa-times"></i>Close</button> </div> </div> </div> </div> <input name="globaluserid" type="hidden" id="globaluserid" class="globaluserid" value=""> <input type="hidden" name="MediaFramework_ItemId" id="MediaFramework_ItemId" value="C4C6F743FA6645D1927B0C87DA0E40DB"> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="3AB62C6D"> <input type="hidden" name="__PREVIOUSPAGE" id="__PREVIOUSPAGE" value="g0p5wpSRwqsJrqJ41LlfYay_MsUmJTQansnXidA8imopkV8JLCUXi7J-D_BG16oYiJzo4W0VndiZSfLS1r7V8O4HmaJl5gnq0orMWNDyj8bbdw11Uwjbw3octEPi9BEUIXql7LtkDPD7xrY1aHBxTq40veybdNjpQw8qjsZTc49_wEvhN4psm8FAUHyyp7GUxoGYNOUeXOvM8K6zPdHtUsZlPtfG4O-Wmhk-PGGix62EIT2b0"> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="/wEdAAno/1XSzURktS6o907QkvJJ7czSd/S7TBHVmlZkP+yaIpTbfn7P1FIJ8rcPUQY/GIz/3PB8hZUsWkSeYLofs0XGIrW4i+FFD+nabBMS5H6eTPojLXFUAKu33ZQrZJn1sP6kf9EcBC10HfrJH2XZ0i44e/26yvRmE2yg8cpculv+n08ij4UWMy6lRXTledJtbSnPKOFlcRbgYJcq8SywVsZeoASgkQ=="> </div></form><script language="javascript" type="text/javascript" src="https://web.archive.org/web/20160810174822js_/http://j3.wyanokecdn.com/healiotwo.1602151030.min.js" defer="defer"></script><script language="javascript" type="text/javascript" src="https://web.archive.org/web/20160810174822js_/http://j3.wyanokecdn.com/bootstrap.min.js" defer="defer"></script><script language="javascript" type="text/javascript" src="https://web.archive.org/web/20160810174822js_/http://j3.wyanokecdn.com/adviewability.1604271059.min.js" defer="defer"></script><script language="javascript" type="text/javascript" src="https://web.archive.org/web/20160810174822js_/http://j3.wyanokecdn.com/newmoduletracking.20151209.1.js" defer="defer"></script><script language="javascript" type="text/javascript" src="https://web.archive.org/web/20160810174822js_/https://cdnjs.cloudflare.com/ajax/libs/jStorage/0.4.12/jstorage.min.js" defer="defer"></script><script language="javascript" type="text/javascript" src="//web.archive.org/web/20160810174822js_/http://cdnjs.cloudflare.com/ajax/libs/jquery.bootstrapvalidator/0.5.1/js/bootstrapValidator.min.js" defer="defer"></script><script language="javascript" type="text/javascript" src="https://web.archive.org/web/20160810174822js_/http://j7.wyanokecdn.com/ae6f6d280ac8d8c5be3935ac1db774cc.js"></script>  <script type="text/javascript"> //$j.nonCachedScript = function (url, options) { // options = $j.extend(options || {}, { // dataType: "script", // cache: false, // url: url // }); // return $j.ajax(options); //}; //$j.nonCachedScript("https://web.archive.org/web/20160810174822/http://j3.wyanokecdn.com/cookieDFP.min.js").done(function (script, textStatus) { }); $j(window).unload(function () { }); //try to break the bfcache $j(document).ready(function () { //handle refresh request if (console.log != "undefined") console.log(window.location.href); var nc = $j.cookie('nc'); if ($j.removeCookie('nc', { path: '/' })) if (nc == "1") window.setTimeout(window.location.reload(true), 100); }); </script> <script type="text/javascript"> //<![CDATA[ (function() { var _analytics_scr = document.createElement('script'); _analytics_scr.type = 'text/javascript'; _analytics_scr.async = true; _analytics_scr.src = '/_Incapsula_Resource?SWJIYLWA=2977d8d74f63d7f8fedbea018b7a1d05&ns=2'; var _analytics_elem = document.getElementsByTagName('script')[0]; _analytics_elem.parentNode.insertBefore(_analytics_scr, _analytics_elem); })(); // ]]> </script></body> </html>

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