CINXE.COM

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type="application/ld+json">[{"@context":"http://schema.org","@type":"SearchResultsPage","about":[{"@type":"Thing","url":["https://www.novusbio.com/products/myd88-inhibitor_nbp2-29328"],"name":["MyD88 Inhibitor Peptide Set"],"image":[[]]},{"@type":"Thing","url":["https://www.novusbio.com/products/tlr4-inhibitor_nbp2-26244"],"name":["TLR4 Inhibitor Peptide Set"],"image":[[{"@type":"ImageObject","caption":"TLR4 Inhibitor Peptide Set [NBP2-26244] - The inhibitor peptide inhibits TLR4 signaling by blocking interactions between TLR4 and its adaptors Mal/TIRAP and TRAM.","url":"https://images.novusbio.com/fullsize/TLR4-Inhibitor-Peptide-Set-NBP2-26244-img0013.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Blocking/Neutralizing: TLR4 Inhibitor Peptide Set [NBP2-26244] - iBMDM cultures were pretreated with 5uM of inhibitor or control prior to stimulation with 20 ng/ml LPS. Negative (LPS-, LPS-/CP7+, LPS-/CP7+) and positive (LPS+) controls were also included. Supernatants were harvested after 6 h and murine TNF-alpha measured by ELISA. TLR4 inhibitor, but not the control, inhibited LPS-induced TNF-alpha production. Image courtesy of Dr. Julianne Stack and Dr. Andrew Bowie, Trinity College, Dublin, Ireland.","url":"https://images.novusbio.com/fullsize/TLR4-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26244-img0015.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"TLR4 Inhibitor Peptide Set [NBP2-26244] - TLR4/MD-2/CD14/NF-kB/SEAPorter stably transfected cells were plated in 96-well plates at 1x10^5 cells/well. After 16 h, cells were preincubated with various concentrations of inhibitor or control peptides (CP) for 1 h. Cells were then stimulated with 10 ng/ml LPS for 24 h. The secreted alkaline phosphatase (SEAP) was analyzed using the SEAPorter Assay Kit. Inhibitory effect on the LPS-mediated TLR4 activation by the VIPER peptide is shown in panel A, and IC50 of the VIPER peptide is described in panel B.","url":"https://images.novusbio.com/fullsize/TLR4-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26244-img0016.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/rela-nfkb-p65-inhibitor_nbp2-26505"],"name":["RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set"],"image":[[{"@type":"ImageObject","caption":"Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - Effect of various p65-inhibitor peptides on binding of purified recombinant p65 protein to the DNA in vitro. Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 for further details).","url":"https://images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser276]-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26505-img0008.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - PTD-p65-P1 peptide inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30 min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer to Takada et al, 2004 for further details).","url":"https://images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser276]-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26505-img0009.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Functional (Inhibition): RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-26505) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test).","url":"https://images.novusbio.com/fullsize/RelA-NFkB-p65-p-Ser276-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-26505-img0010.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/ikk-gamma-inhibitor_nbp2-26504"],"name":["IKK gamma Inhibitor Peptide Set"],"image":[[{"@type":"ImageObject","caption":"In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB as shown by EMSA. U266 cells were treated with 100 uM of control or NBD peptide for different time periods. Nuclear extracts were isolated and checked for NF-kB-DNA binding activity.","url":"https://images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-In-vivo-assay-NBP2-26504-img0010.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB activation in human multiple myeloma cells. U266 cells were treated with 100 uM of control (A & B) or NBD peptide (C & D) for 12 hr, cytospun, plated on glass slides, air dried for 1 hr at room temperature and fixed with cold acetone. Slides were blocked with 5% normal goat serum for 1 hr and then incubated with rabbit polyclonal anti-human p65 antibody (A & C) followed by Ig-Alexa 594 second step. In control peptide treated cells, p65 translocates to nucleus (A), whereas NBD peptide prevents translocation of p65 into the nucleus (C). B & D: Nuclear staining with DNA binding dye.","url":"https://images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-In-vivo-assay-NBP2-26504-img0012.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"IKK gamma Inhibitor Peptide Set [NBP2-26504] - The IKK complex consists of IKKalpha + IKKbeta+ NEMO. NEMO (IKKgamma/NF-kB Essential MOdulator) is a scaffold protein required for the kinase activity of IKKalpha + IKKbeta. NBD (NEMO Binding Domain) inhibits formation of the IKK complex (IKKalpha + IKKbeta+ NEMO) by binding to NEMO and blocking IKK complex formation. In this regard, NBD is considered to be an 'IKKalpha and IKKBeta decoy' Blocking IKK complex formation suppresses downstream events in the NF-kB signaling pathway that rely on the IKK complex including phosphorylation of IkBalpha, and subsequence IkBalpha ubiquination, degradation and release of NF-kB. Hence, NF-kB is retained in the cytoplasm in its inactive state.","url":"https://images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-NBP2-26504-img0014.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Functional (Inhibition): IKK gamma Inhibitor Peptide Set [NBP2-26504] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-26504) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test).","url":"https://images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-26504-img0016.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/traf-6-inhibitor_nbp2-26506"],"name":["TRAF-6 Inhibitor Peptide Set"],"image":[[{"@type":"ImageObject","caption":"TRAF6 Inhibitor Peptide Set [NBP2-26506] - The TRAF6 inhibitory peptide inhibits osteoclast ifferentiation: RAW264.7 cells were plated on 24-well plates and stimulated with RANKL and M-CSF and incubated in the presence of different concentrations of control peptide (PTD) or the TRAF6. The TRAF6 at the concentration above 30 uM suppressed osteoclast differentiation.","url":"https://images.novusbio.com/fullsize/TRAF6-Inhibitor-Peptide-Set-NBP2-26506-img0002.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/rela-nfkb-p65-inhibitor_nbp2-29321"],"name":["RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set"],"image":[[{"@type":"ImageObject","caption":"Western Blot: RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - Inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer toTakada et al, 2004 for further details). 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Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 (3) for further details).","url":"https://images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser529--p-Ser536]-Inhibitor-Peptide-Set-Western-Blot-NBP2-29321-img0013.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Functional (Inhibition): RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29321) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test).","url":"https://images.novusbio.com/fullsize/RelA-NFkB-p65-p-Ser529-p-Ser536-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-29321-img0012.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/nfkb-p50-nls-inhibitor_nbp2-29323"],"name":["NFkB p50 (NLS) Inhibitor Peptide Set"],"image":[[{"@type":"ImageObject","caption":"Functional (Inhibition): NFkB p105/p50 Inhibitor Peptide Set [NBP2-29323] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29323) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. 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class="search_facet_name">Chicken<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Hamster" rel="nofollow"><span data-facet="Hamster (1)" class="search_facet_name">Hamster<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Human" rel="nofollow"><span data-facet="Human (15)" class="search_facet_name">Human<span class=facet_count> (15)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Mammal" rel="nofollow"><span data-facet="Mammal (1)" class="search_facet_name">Mammal<span class=facet_count> (1)</span></span></a></li></ul><ul class="more_facets"><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Mouse" rel="nofollow"><span data-facet="Mouse (12)" class="search_facet_name">Mouse<span class=facet_count> (12)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Rabbit" rel="nofollow"><span data-facet="Rabbit (1)" class="search_facet_name">Rabbit<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Rat" rel="nofollow"><span data-facet="Rat (8)" class="search_facet_name">Rat<span class=facet_count> (8)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Xenopus" rel="nofollow"><span data-facet="Xenopus (3)" class="search_facet_name">Xenopus<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Yeast" rel="nofollow"><span data-facet="Yeast (1)" class="search_facet_name">Yeast<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/inhibitors?species=Zebrafish" rel="nofollow"><span data-facet="Zebrafish (1)" class="search_facet_name">Zebrafish<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_citation"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Citation</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/product-type/inhibitors?count_publications=1" rel="nofollow"><span data-facet="1 or more (20)" class="search_facet_name">1 or more (20)</span></a></li><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/product-type/inhibitors?count_publications=10" rel="nofollow"><span data-facet="10 or more (9)" class="search_facet_name">10 or more (9)</span></a></li><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/product-type/inhibitors?count_publications=100" rel="nofollow"><span data-facet="100 or more (1)" class="search_facet_name">100 or more (1)</span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_reviews"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Reviews</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_stars_novus" class="facet_input"><a href="/product-type/inhibitors?stars_novus=5.0" rel="nofollow"><span data-facet=" 5 (2)" class="search_facet_name"><span class="searchImage_star5"></span> 5 (2)</span></a></li><li><input type="radio" name="fc_stars_novus" class="facet_input"><a href="/product-type/inhibitors?stars_novus=4.0" rel="nofollow"><span data-facet=" 4 & Up (3)" class="search_facet_name"><span class="searchImage_star4"></span> 4 & Up (3)</span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_modification"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Modification</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_modification" class="facet_input"><a href="/product-type/inhibitors?modification=No%20Modification" rel="nofollow"><span data-facet="No Modification (25)" class="search_facet_name">No Modification<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_modification" class="facet_input"><a href="/product-type/inhibitors?modification=p%20Ser276" rel="nofollow"><span data-facet="p Ser276 (1)" class="search_facet_name">p Ser276<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_modification" class="facet_input"><a href="/product-type/inhibitors?modification=p%20Ser529,%20p%20Ser536" rel="nofollow"><span data-facet="p Ser529, p Ser536 (1)" class="search_facet_name">p Ser529, p Ser536<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_gene-symbol"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Gene Symbol</span></h4> <div class="facet_list compacted"><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=TIRAP" rel="nofollow"><span data-facet="TIRAP (3)" class="search_facet_name">TIRAP<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=RELA" rel="nofollow"><span data-facet="RELA (2)" class="search_facet_name">RELA<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=TLR4" rel="nofollow"><span data-facet="TLR4 (2)" class="search_facet_name">TLR4<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=AKT1" rel="nofollow"><span data-facet="AKT1 (1)" class="search_facet_name">AKT1<span class=facet_count> (1)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=AKT1" rel="nofollow"><span data-facet="AKT1 (1)" class="search_facet_name">AKT1<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=IKBKG" rel="nofollow"><span data-facet="IKBKG (1)" class="search_facet_name">IKBKG<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=MAPK3" rel="nofollow"><span data-facet="MAPK3 (1)" class="search_facet_name">MAPK3<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=MYD88" rel="nofollow"><span data-facet="MYD88 (1)" class="search_facet_name">MYD88<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=NFKB1" rel="nofollow"><span data-facet="NFKB1 (1)" class="search_facet_name">NFKB1<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=RELA" rel="nofollow"><span data-facet="RELA (2)" class="search_facet_name">RELA<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=TIRAP" rel="nofollow"><span data-facet="TIRAP (3)" class="search_facet_name">TIRAP<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=TLR4" rel="nofollow"><span data-facet="TLR4 (2)" class="search_facet_name">TLR4<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/inhibitors?gene_symbol=TRAF6" rel="nofollow"><span data-facet="TRAF6 (1)" class="search_facet_name">TRAF6<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_images-type"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Images Type</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/inhibitors?images_type=Functional%20(Inhibition)" rel="nofollow"><span data-facet="Functional (Inhibition) (5)" class="search_facet_name">Functional (Inhibition)<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/inhibitors?images_type=In%20vivo%20assay" rel="nofollow"><span data-facet="In vivo assay (1)" class="search_facet_name">In vivo assay<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/inhibitors?images_type=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (1)" class="search_facet_name">Western Blot<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_inhibitor-family"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Inhibitor Family</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_inhibitor_family" class="facet_input"><a href="/product-type/inhibitors?inhibitor_family=Caspase" rel="nofollow"><span data-facet="Caspase (6)" class="search_facet_name">Caspase<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_inhibitor_family" class="facet_input"><a href="/product-type/inhibitors?inhibitor_family=NFkB" rel="nofollow"><span data-facet="NFkB (5)" class="search_facet_name">NFkB<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_inhibitor_family" class="facet_input"><a href="/product-type/inhibitors?inhibitor_family=TLR" rel="nofollow"><span data-facet="TLR (5)" class="search_facet_name">TLR<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_inhibitor_family" class="facet_input"><a href="/product-type/inhibitors?inhibitor_family=AKT" rel="nofollow"><span data-facet="AKT (1)" class="search_facet_name">AKT<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_family" class="facet_input"><a href="/product-type/inhibitors?inhibitor_family=ERK" rel="nofollow"><span data-facet="ERK (1)" class="search_facet_name">ERK<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_family" class="facet_input"><a href="/product-type/inhibitors?inhibitor_family=Th17%20and%20IL17" rel="nofollow"><span data-facet="Th17 and IL17 (1)" class="search_facet_name">Th17 and IL17<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_inhibitor-target"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Inhibitor Target</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=TLR2%20and%20TLR4" rel="nofollow"><span data-facet="TLR2 and TLR4 (3)" class="search_facet_name">TLR2 and TLR4<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=NFkB%20p65" rel="nofollow"><span data-facet="NFkB p65 (2)" class="search_facet_name">NFkB p65<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=AKT1/2/3" rel="nofollow"><span data-facet="AKT1/2/3 (1)" class="search_facet_name">AKT1 / 2/3<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=Caspase%203/7" rel="nofollow"><span data-facet="Caspase 3/7 (1)" class="search_facet_name">Caspase 3 / 7<span class=facet_count> (1)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=AKT1/2/3" rel="nofollow"><span data-facet="AKT1 / 2/3 (1)" class="search_facet_name">AKT1 / 2/3<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=Caspase%203/7" rel="nofollow"><span data-facet="Caspase 3 / 7 (1)" class="search_facet_name">Caspase 3 / 7<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=Caspase%208" rel="nofollow"><span data-facet="Caspase 8 (1)" class="search_facet_name">Caspase 8<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=Caspase%209" rel="nofollow"><span data-facet="Caspase 9 (1)" class="search_facet_name">Caspase 9<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=IL-17A" rel="nofollow"><span data-facet="IL-17A (1)" class="search_facet_name">IL-17A<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=MyD88" rel="nofollow"><span data-facet="MyD88 (1)" class="search_facet_name">MyD88<span class=facet_count> (1)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=NBD" rel="nofollow"><span data-facet="NBD (1)" class="search_facet_name">NBD<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=NFkB%20p50" rel="nofollow"><span data-facet="NFkB p50 (1)" class="search_facet_name">NFkB p50<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=NFkB%20p65" rel="nofollow"><span data-facet="NFkB p65 (2)" class="search_facet_name">NFkB p65<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=NLRP3" rel="nofollow"><span data-facet="NLRP3 (1)" class="search_facet_name">NLRP3<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=ROR%20gamma%20T%20and%20ROR%20alpha" rel="nofollow"><span data-facet="ROR gamma T and ROR alpha (1)" class="search_facet_name">ROR gamma T and ROR alpha<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=TLR2%20and%20TLR4" rel="nofollow"><span data-facet="TLR2 and TLR4 (3)" class="search_facet_name">TLR2 and TLR4<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=TLR4" rel="nofollow"><span data-facet="TLR4 (1)" class="search_facet_name">TLR4<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=TRAF6" rel="nofollow"><span data-facet="TRAF6 (1)" class="search_facet_name">TRAF6<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_inhibitor_target" class="facet_input"><a href="/product-type/inhibitors?inhibitor_target=pan%20Caspase" rel="nofollow"><span data-facet="pan Caspase (1)" class="search_facet_name">pan Caspase<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/inhibitors?" class="search_clear_link">clear</a><div class="facet_container_research-areas"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Research Areas</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Immunology" rel="nofollow"><span data-facet="Immunology (10)" class="search_facet_name">Immunology<span class=facet_count> (10)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Innate%20Immunity" rel="nofollow"><span data-facet="Innate Immunity (10)" class="search_facet_name">Innate Immunity<span class=facet_count> (10)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Signal%20Transduction" rel="nofollow"><span data-facet="Signal Transduction (7)" class="search_facet_name">Signal Transduction<span class=facet_count> (7)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Cancer" rel="nofollow"><span data-facet="Cancer (5)" class="search_facet_name">Cancer<span class=facet_count> (5)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Adaptive%20Immunity" rel="nofollow"><span data-facet="Adaptive Immunity (2)" class="search_facet_name">Adaptive Immunity<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Angiogenesis" rel="nofollow"><span data-facet="Angiogenesis (1)" class="search_facet_name">Angiogenesis<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Apoptosis" rel="nofollow"><span data-facet="Apoptosis (4)" class="search_facet_name">Apoptosis<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Autophagy" rel="nofollow"><span data-facet="Autophagy (3)" class="search_facet_name">Autophagy<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Breast%20Cancer" rel="nofollow"><span data-facet="Breast Cancer (1)" class="search_facet_name">Breast Cancer<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Cancer" rel="nofollow"><span data-facet="Cancer (5)" class="search_facet_name">Cancer<span class=facet_count> (5)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Cell%20Biology" rel="nofollow"><span data-facet="Cell Biology (2)" class="search_facet_name">Cell Biology<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Cell%20Cycle%20and%20Replication" rel="nofollow"><span data-facet="Cell Cycle and Replication (1)" class="search_facet_name">Cell Cycle and Replication<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Cytokine%20Research" rel="nofollow"><span data-facet="Cytokine Research (3)" class="search_facet_name">Cytokine Research<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Diabetes%20Research" rel="nofollow"><span data-facet="Diabetes Research (1)" class="search_facet_name">Diabetes Research<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_research_areas" class="facet_input"><a href="/product-type/inhibitors?research_areas=Growth%20and%20Development" rel="nofollow"><span data-facet="Growth and Development (1)" class="search_facet_name">Growth and Development<span class=facet_count> (1)</span></span></a></li><li><input 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class="search_results"> <div class="search_sort"> Sort By: <select id="search_type_select"><option value="/product-type/inhibitors?sort=ranking,desc">Best Match</option><option value="/product-type/inhibitors?sort=product_title,asc">Products (A-Z)</option><option value="/product-type/inhibitors?sort=product_added,desc">Newest</option><option value="/product-type/inhibitors?sort=count_publications,desc">Publications</option> </select> </div><div class="modalWrapper" style="display:none;"> <h2>Species Glossary</h2> <hr class="customhr"/> <img src="//images.novusbio.com/design/bunny.gif" alt="Species Glossary Rabbit" style="float: right;"> <table class="modalTable"> <tr> <td>At</td> <td>=</td> <td>A. thaliana</td> <td>SyHa</td> <td>=</td> <td>Golden Syrian Hamster</td> </tr> <tr> <td>All</td> <td>=</td> <td>All Species</td> <td>Ha</td> <td>=</td> <td>Hamster</td> </tr> <tr> <td>An</td> <td>=</td> <td>Animal</td> <td>Hu</td> <td>=</td> <td>Human</td> </tr> <tr> <td>ArHa</td> <td>=</td> <td>Armenian Hamster</td> <td>I</td> <td>=</td> <td>Insect</td> </tr> <tr> <td>Av</td> <td>=</td> <td>Avian</td> <td>Ll</td> <td>=</td> <td>Llama</td> </tr> <tr> <td>Bb</td> <td>=</td> <td>Baboon</td> <td>Ma</td> <td>=</td> <td>Mammal</td> </tr> <tr> <td>Ba</td> <td>=</td> <td>Bacteria</td> <td>Mk</td> <td>=</td> <td>Monkey</td> </tr> <tr> <td>Bv</td> <td>=</td> <td>Bovine</td> <td>Mu</td> <td>=</td> <td>Mouse</td> </tr> <tr> <td>Ca</td> <td>=</td> <td>Canine</td> <td>Multi</td> <td>=</td> <td>Multi-species</td> </tr> <tr> <td>Ce</td> <td>=</td> <td>C. Elegans</td> <td>NA</td> <td>=</td> <td>Non-species specific</td> </tr> <tr> <td>Ch</td> <td>=</td> <td>Chicken</td> <td>Or</td> <td>=</td> <td>Orangutan</td> </tr> <tr> <td>ChHa</td> <td>=</td> <td>Chinese Hamster</td> <td>Pl</td> <td>=</td> <td>Plant</td> </tr> <tr> <td>Cm</td> <td>=</td> <td>Cynomolgus Monkey</td> <td>Pm</td> <td>=</td> <td>Primate</td> </tr> <tr> <td>Do</td> <td>=</td> <td>Donkey</td> <td>Po</td> <td>=</td> <td>Porcine</td> </tr> <tr> <td>Dr</td> <td>=</td> <td>Drosophilia</td> <td>Rb</td> <td>=</td> <td>Rabbit</td> </tr> <tr> <td>Ec</td> <td>=</td> <td>E. Coli</td> <td>Rt</td> <td>=</td> <td>Rat</td> </tr> <tr> <td>Eq</td> <td>=</td> <td>Equine</td> <td>RM</td> <td>=</td> <td>Rhesus Macaque</td> </tr> <tr> <td>Fe</td> <td>=</td> <td>Feline</td> <td>Sh</td> <td>=</td> <td>Sheep</td> </tr> <tr> <td>Ft</td> <td>=</td> <td>Ferret</td> <td>Vb</td> <td>=</td> <td>Vertebrate</td> </tr> <tr> <td>Fi</td> <td>=</td> <td>Fish</td> <td>Vi</td> <td>=</td> <td>Virus</td> </tr> <tr> <td>Fu</td> <td>=</td> <td>Fungi</td> <td>Xp</td> <td>=</td> <td>Xenopus</td> </tr> <tr> <td>Ge</td> <td>=</td> <td>Gerbil</td> <td>Ye</td> <td>=</td> <td>Yeast</td> </tr> <tr> <td>GP</td> <td>=</td> <td>Guinea Pig</td> <td>Ze</td> <td>=</td> <td>Zebrafish</td> </tr> <tr> <td>Gt</td> <td>=</td> <td>Goat</td> </tr> </table> <div style="text-align: center;margin-left:25px;margin-right:25px;"> <p>Note: Mouseover a species abbreviation on the product page to display the fullname.</p> </div> </div> <div class="search_type"><ul> <li class="active">Products (27)</li><a href="/fssearch?keywords=novus" rel="nofollow"><li>Full Site</li></a></ul></div><div class="search_results_framework"><div class="upper_framework"> <div class="search_pager"><div class="searchImage_backGrey" style="display:inline-block;zoom:1;width:6px;height:11px;background:url(//resources.rndsystems.com/images/search/searchSprite03-31-16.png) -18px -169px"></div> page <input type="text" value="1" class="search_pager_text" data-url="/product-type/inhibitors?page="> of <span class="search_total_pages">3</span> <div class="search_page forward" style="display:inline-block;zoom:1"><a href="/product-type/inhibitors?page=2" rel="nofollow" class="active"><div class="searchImage_forward" style="display:inline-block;zoom:1;width:6px;height:11px;background:url(//resources.rndsystems.com/images/search/searchSprite03-31-16.png) -7px -152px"></div></a></div> </div><h1 style="padding: 0; margin: 5px 0; font-size: 20px;">Inhibitors</h1><div><p>Inhibitors are substances that suppress or slow the activity of other substances, such as enzymes. Enzyme inhibitors bind to the catalytic site of enzymes, thus decreasing their activity. Novus provides a variety of caspase inhibitors, including Caspase-1 Inhibitors, Caspase-3 Inhibitors, Caspase-6 Inhibitors, Caspase-7 Inhibitors, Caspase-8 Inhibitors, Caspase-9 Inhibitors, and Caspase-12 Inhibitors. Novus also offers various pathway inhibitors, such as ERK Pathway Inhibitory Peptides, NF-kappaB Pathway Inhibitory Peptides, NOD-Like Receptor Inhibitors, AKT Pathway Inhibitors and TLR Pathway Inhibitors.</p></div><div class="search_summary">27 Results for ""</div><div class="grpListGrid"> <div class="outdiv"><a href="/product-type/inhibitors?showGrid=false" class="active_link" rel="nofollow"> <div class="listView"></div> List</a></div> <div class="outdiv listgriddivider"><a href="/product-type/inhibitors?showGrid=true" class="notactive_link" rel="nofollow"> <div class="gridView"></div> Grid</a></div> </div></div><div id="equalize"><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/myd88-inhibitor_nbp2-29328">NBP2-29328</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-29328" data-name="MyD88 Inhibitor Peptide Set" data-position="1" class="ecommerce_link" href="/products/myd88-inhibitor_nbp2-29328" title="MyD88 Inhibitor Peptide Set" ><span> MyD88 Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="3 Reviews for this product" href="/products/myd88-inhibitor_nbp2-29328#ReviewsSection"><span class="stars5"></span> (3 Reviews)</a> </div> <div class="segment"> <a title="100 Publications specific to this product" href="/products/myd88-inhibitor_nbp2-29328#PublicationSection"><span class="publications"></span> (100 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-29328"></span> </div> </div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Xenopus">Xp</span>, <span title="Yeast">Ye</span>, <span title="Zebrafish">Ze</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Xenopus">Xp</span>, <span title="Yeast">Ye</span>, <span title="Zebrafish">Ze</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2005</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2005</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-29328","Product Name":"MyD88 Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat, Bovine, Xenopus, Yeast, Zebrafish","Applications":"ELISA, Flow, Func, IHC, Inhibition Activity, B\/N","Source":"","Purification":"","Immunogen":"Functions as a decoy by binding to the MyD88 TIR domain.","Citations":"100","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/myd88-inhibitor_nbp2-29328\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/tlr4-inhibitor_nbp2-26244">NBP2-26244</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-26244" data-name="TLR4 Inhibitor Peptide Set" data-position="2" class="ecommerce_link" href="/products/tlr4-inhibitor_nbp2-26244" title="TLR4 Inhibitor Peptide Set" ><span> TLR4 Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/tlr4-inhibitor_nbp2-26244#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="47 Publications specific to this product" href="/products/tlr4-inhibitor_nbp2-26244#PublicationSection"><span class="publications"></span> (47 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 Vials</strong><span class="product_price" data-sku="NBP2-26244"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/tlr4-inhibitor_nbp2-26244">NBP2-26244</a> </div><div id="ss_prev1" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-1" data-cycle-prev="#ss_prev1" data-cycle-next="#ss_next1" data-cycle-caption="#image-caption-NBP2-26244" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/TLR4-Inhibitor-Peptide-Set-NBP2-26244-img0013.jpg" title="TLR4 Inhibitor Peptide Set [NBP2-26244] - The inhibitor peptide inhibits TLR4 signaling by blocking interactions between TLR4 and its adaptors Mal/TIRAP and TRAM." class="big_lightbox"> <img src="//images.novusbio.com/images/TLR4-Inhibitor-Peptide-Set-NBP2-26244-img0013.jpg" title="TLR4 Inhibitor Peptide Set [NBP2-26244] - The inhibitor peptide inhibits TLR4 signaling by blocking interactions between TLR4 and its adaptors Mal/TIRAP and TRAM." alt="TLR4 Inhibitor Peptide Set [NBP2-26244] - The inhibitor peptide inhibits TLR4 signaling by blocking interactions between TLR4 and its adaptors Mal/TIRAP and TRAM." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/TLR4-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26244-img0015.jpg" title="Blocking/Neutralizing: TLR4 Inhibitor Peptide Set [NBP2-26244] - iBMDM cultures were pretreated with 5uM of inhibitor or control prior to stimulation with 20 ng/ml LPS. Negative (LPS-, LPS-/CP7+, LPS-/CP7+) and positive (LPS+) controls were also included. Supernatants were harvested after 6 h and murine TNF-alpha measured by ELISA. TLR4 inhibitor, but not the control, inhibited LPS-induced TNF-alpha production. Image courtesy of Dr. Julianne Stack and Dr. Andrew Bowie, Trinity College, Dublin, Ireland." class="big_lightbox"> <img src="//images.novusbio.com/images/TLR4-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26244-img0015.jpg" alt="Blocking/Neutralizing: TLR4 Inhibitor Peptide Set [NBP2-26244] - iBMDM cultures were pretreated with 5uM of inhibitor or control prior to stimulation with 20 ng/ml LPS. Negative (LPS-, LPS-/CP7+, LPS-/CP7+) and positive (LPS+) controls were also included. Supernatants were harvested after 6 h and murine TNF-alpha measured by ELISA. TLR4 inhibitor, but not the control, inhibited LPS-induced TNF-alpha production. Image courtesy of Dr. Julianne Stack and Dr. Andrew Bowie, Trinity College, Dublin, Ireland." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/TLR4-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26244-img0016.jpg" title="TLR4 Inhibitor Peptide Set [NBP2-26244] - TLR4/MD-2/CD14/NF-kB/SEAPorter stably transfected cells were plated in 96-well plates at 1x10^5 cells/well. After 16 h, cells were preincubated with various concentrations of inhibitor or control peptides (CP) for 1 h. Cells were then stimulated with 10 ng/ml LPS for 24 h. The secreted alkaline phosphatase (SEAP) was analyzed using the SEAPorter Assay Kit. Inhibitory effect on the LPS-mediated TLR4 activation by the VIPER peptide is shown in panel A, and IC50 of the VIPER peptide is described in panel B." class="big_lightbox"> <img src="//images.novusbio.com/images/TLR4-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26244-img0016.jpg" alt="TLR4 Inhibitor Peptide Set [NBP2-26244] - TLR4/MD-2/CD14/NF-kB/SEAPorter stably transfected cells were plated in 96-well plates at 1x10^5 cells/well. After 16 h, cells were preincubated with various concentrations of inhibitor or control peptides (CP) for 1 h. Cells were then stimulated with 10 ng/ml LPS for 24 h. The secreted alkaline phosphatase (SEAP) was analyzed using the SEAPorter Assay Kit. Inhibitory effect on the LPS-mediated TLR4 activation by the VIPER peptide is shown in panel A, and IC50 of the VIPER peptide is described in panel B." class="big_thumb" /> </a> </div></div><div id="ss_next1" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-1" class="cycle-circle-pager"></div><div id="image-caption-NBP2-26244"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2011set</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2011set</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-26244","Product Name":"TLR4 Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat","Applications":"Flow, Func, B\/N","Source":"","Purification":"","Immunogen":"","Citations":"47","Purity":">95%, by HPLC.","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/tlr4-inhibitor_nbp2-26244\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/rela-nfkb-p65-inhibitor_nbp2-26505">NBP2-26505</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-26505" data-name="RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set" data-position="3" class="ecommerce_link" href="/products/rela-nfkb-p65-inhibitor_nbp2-26505" title="RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set" ><span> RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="23 Publications specific to this product" href="/products/rela-nfkb-p65-inhibitor_nbp2-26505#PublicationSection"><span class="publications"></span> (23 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-26505"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/rela-nfkb-p65-inhibitor_nbp2-26505">NBP2-26505</a> </div><div id="ss_prev2" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-2" data-cycle-prev="#ss_prev2" data-cycle-next="#ss_next2" data-cycle-caption="#image-caption-NBP2-26505" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser276]-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26505-img0008.jpg" title="Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - Effect of various p65-inhibitor peptides on binding of purified recombinant p65 protein to the DNA in vitro. Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 for further details)." class="big_lightbox"> <img src="//images.novusbio.com/images/RelA-NFkB-p65-[p-Ser276]-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26505-img0008.jpg" title="Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - Effect of various p65-inhibitor peptides on binding of purified recombinant p65 protein to the DNA in vitro. Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 for further details)." alt="Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - Effect of various p65-inhibitor peptides on binding of purified recombinant p65 protein to the DNA in vitro. Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 for further details)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser276]-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26505-img0009.jpg" title="Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - PTD-p65-P1 peptide inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30 min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer to Takada et al, 2004 for further details)." class="big_lightbox"> <img src="//images.novusbio.com/images/RelA-NFkB-p65-[p-Ser276]-Inhibitor-Peptide-Set-Blocking-Neutralizing-NBP2-26505-img0009.jpg" alt="Blocking/Neutralizing: RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - PTD-p65-P1 peptide inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30 min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer to Takada et al, 2004 for further details)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/RelA-NFkB-p65-p-Ser276-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-26505-img0010.jpg" title="Functional (Inhibition): RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-26505) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_lightbox"> <img src="//images.novusbio.com/images/RelA-NFkB-p65-p-Ser276-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-26505-img0010.jpg" alt="Functional (Inhibition): RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set [NBP2-26505] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-26505) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_thumb" /> </a> </div></div><div id="ss_next2" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-2" class="cycle-circle-pager"></div><div id="image-caption-NBP2-26505"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span>, <span title="Mammal">Ma</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span>, <span title="Mammal">Ma</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2001</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2001</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-26505","Product Name":"RelA\/NFkB p65 [p Ser276] Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat, Bovine, Canine, Mammal","Applications":"Func, Inhibition Activity, B\/N","Source":"","Purification":"","Immunogen":"Functions as a p65 decoy through phosphorylation of the Ser276 site on the peptide.","Citations":"23","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/rela-nfkb-p65-inhibitor_nbp2-26505\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/ikk-gamma-inhibitor_nbp2-26504">NBP2-26504</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-26504" data-name="IKK gamma Inhibitor Peptide Set" data-position="4" class="ecommerce_link" href="/products/ikk-gamma-inhibitor_nbp2-26504" title="IKK gamma Inhibitor Peptide Set" ><span> IKK gamma Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="22 Publications specific to this product" href="/products/ikk-gamma-inhibitor_nbp2-26504#PublicationSection"><span class="publications"></span> (22 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-26504"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/ikk-gamma-inhibitor_nbp2-26504">NBP2-26504</a> </div><div id="ss_prev3" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-3" data-cycle-prev="#ss_prev3" data-cycle-next="#ss_next3" data-cycle-caption="#image-caption-NBP2-26504" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-In-vivo-assay-NBP2-26504-img0010.jpg" title="In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB as shown by EMSA. U266 cells were treated with 100 uM of control or NBD peptide for different time periods. Nuclear extracts were isolated and checked for NF-kB-DNA binding activity." class="big_lightbox"> <img src="//images.novusbio.com/images/IKK-gamma-Inhibitor-Peptide-Set-In-vivo-assay-NBP2-26504-img0010.jpg" title="In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB as shown by EMSA. U266 cells were treated with 100 uM of control or NBD peptide for different time periods. Nuclear extracts were isolated and checked for NF-kB-DNA binding activity." alt="In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB as shown by EMSA. U266 cells were treated with 100 uM of control or NBD peptide for different time periods. Nuclear extracts were isolated and checked for NF-kB-DNA binding activity." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-In-vivo-assay-NBP2-26504-img0012.jpg" title="In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB activation in human multiple myeloma cells. U266 cells were treated with 100 uM of control (A & B) or NBD peptide (C & D) for 12 hr, cytospun, plated on glass slides, air dried for 1 hr at room temperature and fixed with cold acetone. Slides were blocked with 5% normal goat serum for 1 hr and then incubated with rabbit polyclonal anti-human p65 antibody (A & C) followed by Ig-Alexa 594 second step. In control peptide treated cells, p65 translocates to nucleus (A), whereas NBD peptide prevents translocation of p65 into the nucleus (C). B & D: Nuclear staining with DNA binding dye." class="big_lightbox"> <img src="//images.novusbio.com/images/IKK-gamma-Inhibitor-Peptide-Set-In-vivo-assay-NBP2-26504-img0012.jpg" alt="In vivo assay: IKK gamma Inhibitor Peptide Set [NBP2-26504] - NBD peptide blocks constitutive NF-kB activation in human multiple myeloma cells. U266 cells were treated with 100 uM of control (A & B) or NBD peptide (C & D) for 12 hr, cytospun, plated on glass slides, air dried for 1 hr at room temperature and fixed with cold acetone. Slides were blocked with 5% normal goat serum for 1 hr and then incubated with rabbit polyclonal anti-human p65 antibody (A & C) followed by Ig-Alexa 594 second step. In control peptide treated cells, p65 translocates to nucleus (A), whereas NBD peptide prevents translocation of p65 into the nucleus (C). B & D: Nuclear staining with DNA binding dye." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-NBP2-26504-img0014.jpg" title="IKK gamma Inhibitor Peptide Set [NBP2-26504] - The IKK complex consists of IKKalpha + IKKbeta+ NEMO. NEMO (IKKgamma/NF-kB Essential MOdulator) is a scaffold protein required for the kinase activity of IKKalpha + IKKbeta. NBD (NEMO Binding Domain) inhibits formation of the IKK complex (IKKalpha + IKKbeta+ NEMO) by binding to NEMO and blocking IKK complex formation. In this regard, NBD is considered to be an 'IKKalpha and IKKBeta decoy' Blocking IKK complex formation suppresses downstream events in the NF-kB signaling pathway that rely on the IKK complex including phosphorylation of IkBalpha, and subsequence IkBalpha ubiquination, degradation and release of NF-kB. Hence, NF-kB is retained in the cytoplasm in its inactive state." class="big_lightbox"> <img src="//images.novusbio.com/images/IKK-gamma-Inhibitor-Peptide-Set-NBP2-26504-img0014.jpg" alt="IKK gamma Inhibitor Peptide Set [NBP2-26504] - The IKK complex consists of IKKalpha + IKKbeta+ NEMO. NEMO (IKKgamma/NF-kB Essential MOdulator) is a scaffold protein required for the kinase activity of IKKalpha + IKKbeta. NBD (NEMO Binding Domain) inhibits formation of the IKK complex (IKKalpha + IKKbeta+ NEMO) by binding to NEMO and blocking IKK complex formation. In this regard, NBD is considered to be an 'IKKalpha and IKKBeta decoy' Blocking IKK complex formation suppresses downstream events in the NF-kB signaling pathway that rely on the IKK complex including phosphorylation of IkBalpha, and subsequence IkBalpha ubiquination, degradation and release of NF-kB. Hence, NF-kB is retained in the cytoplasm in its inactive state." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/IKK-gamma-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-26504-img0016.jpg" title="Functional (Inhibition): IKK gamma Inhibitor Peptide Set [NBP2-26504] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-26504) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_lightbox"> <img src="//images.novusbio.com/images/IKK-gamma-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-26504-img0016.jpg" alt="Functional (Inhibition): IKK gamma Inhibitor Peptide Set [NBP2-26504] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-26504) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_thumb" /> </a> </div></div><div id="ss_next3" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-3" class="cycle-circle-pager"></div><div id="image-caption-NBP2-26504"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2000</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2000</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-26504","Product Name":"IKK gamma Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat","Applications":"Func, Inhibition Activity, B\/N","Source":"","Purification":"","Immunogen":"Functions as an IKK-Alpha\/IKK-Beta decoy by binding to IKK-Gamma NBD, thereby preventing formation of the IKK complex.","Citations":"22","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/ikk-gamma-inhibitor_nbp2-26504\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/traf-6-inhibitor_nbp2-26506">NBP2-26506</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-26506" data-name="TRAF-6 Inhibitor Peptide Set" data-position="5" class="ecommerce_link" href="/products/traf-6-inhibitor_nbp2-26506" title="TRAF-6 Inhibitor Peptide Set" ><span> TRAF-6 Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="19 Publications specific to this product" href="/products/traf-6-inhibitor_nbp2-26506#PublicationSection"><span class="publications"></span> (19 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-26506"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/traf-6-inhibitor_nbp2-26506">NBP2-26506</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-4" data-cycle-prev="#ss_prev4" data-cycle-next="#ss_next4" data-cycle-caption="#image-caption-NBP2-26506" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/TRAF6-Inhibitor-Peptide-Set-NBP2-26506-img0002.jpg" title="TRAF6 Inhibitor Peptide Set [NBP2-26506] - The TRAF6 inhibitory peptide inhibits osteoclast ifferentiation: RAW264.7 cells were plated on 24-well plates and stimulated with RANKL and M-CSF and incubated in the presence of different concentrations of control peptide (PTD) or the TRAF6. The TRAF6 at the concentration above 30 uM suppressed osteoclast differentiation." class="big_lightbox"> <img src="//images.novusbio.com/images/TRAF6-Inhibitor-Peptide-Set-NBP2-26506-img0002.jpg" title="TRAF6 Inhibitor Peptide Set [NBP2-26506] - The TRAF6 inhibitory peptide inhibits osteoclast ifferentiation: RAW264.7 cells were plated on 24-well plates and stimulated with RANKL and M-CSF and incubated in the presence of different concentrations of control peptide (PTD) or the TRAF6. The TRAF6 at the concentration above 30 uM suppressed osteoclast differentiation." alt="TRAF6 Inhibitor Peptide Set [NBP2-26506] - The TRAF6 inhibitory peptide inhibits osteoclast ifferentiation: RAW264.7 cells were plated on 24-well plates and stimulated with RANKL and M-CSF and incubated in the presence of different concentrations of control peptide (PTD) or the TRAF6. The TRAF6 at the concentration above 30 uM suppressed osteoclast differentiation." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-NBP2-26506"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Block/Neutralize">B/N</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2002</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2002</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-26506","Product Name":"TRAF-6 Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat","Applications":"Func, B\/N","Source":"","Purification":"","Immunogen":"Functions as a TRAF6 decoy by binding to the T6DP motif of RANK, thereby preventing binding of RANK to TRAF6.","Citations":"19","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/traf-6-inhibitor_nbp2-26506\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/rela-nfkb-p65-inhibitor_nbp2-29321">NBP2-29321</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-29321" data-name="RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set" data-position="6" class="ecommerce_link" href="/products/rela-nfkb-p65-inhibitor_nbp2-29321" title="RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set" ><span> RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="13 Publications specific to this product" href="/products/rela-nfkb-p65-inhibitor_nbp2-29321#PublicationSection"><span class="publications"></span> (13 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-29321"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/rela-nfkb-p65-inhibitor_nbp2-29321">NBP2-29321</a> </div><div id="ss_prev5" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-5" data-cycle-prev="#ss_prev5" data-cycle-next="#ss_next5" data-cycle-caption="#image-caption-NBP2-29321" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser529--p-Ser536]-Inhibitor-Peptide-Set-Western-Blot-NBP2-29321-img0015.jpg" title="Western Blot: RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - Inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer toTakada et al, 2004 for further details). PTD-p65-P6 suppresses TNF-induced NF-kB activation by 25% at 100 uM and completely at 150 uM, where as the control peptide, PTD or p65-P6 without PTD did not have any effect." class="big_lightbox"> <img src="//images.novusbio.com/images/RelA-NFkB-p65-[p-Ser529--p-Ser536]-Inhibitor-Peptide-Set-Western-Blot-NBP2-29321-img0015.jpg" title="Western Blot: RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - Inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer toTakada et al, 2004 for further details). PTD-p65-P6 suppresses TNF-induced NF-kB activation by 25% at 100 uM and completely at 150 uM, where as the control peptide, PTD or p65-P6 without PTD did not have any effect." alt="Western Blot: RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - Inhibits TNF-induced NF-kB activation: KBM-5 cells were incubated with various concentrations of peptides for 1 hr and treated with 0.1nM TNF for 30min. Nuclear extracts were prepared and NF-kB activation was analyzed by EMSA (Please refer toTakada et al, 2004 for further details). PTD-p65-P6 suppresses TNF-induced NF-kB activation by 25% at 100 uM and completely at 150 uM, where as the control peptide, PTD or p65-P6 without PTD did not have any effect." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/RelA-NFkB-p65-[p-Ser529--p-Ser536]-Inhibitor-Peptide-Set-Western-Blot-NBP2-29321-img0013.jpg" title="Western Blot: RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - Effect of various p65-inhibitor peptides on binding of purified recombinant p65 protein to the DNA in vitro. Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 (3) for further details)." class="big_lightbox"> <img src="//images.novusbio.com/images/RelA-NFkB-p65-[p-Ser529--p-Ser536]-Inhibitor-Peptide-Set-Western-Blot-NBP2-29321-img0013.jpg" alt="Western Blot: RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - Effect of various p65-inhibitor peptides on binding of purified recombinant p65 protein to the DNA in vitro. Recombinant p65 protein (100 ng/sample) was incubated for 30 minutes with 50uM of various peptides in 0.025 ml and then assayed for DNA binding activity by EMSA (Please refer to Takada et al, 2004 (3) for further details)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/RelA-NFkB-p65-p-Ser529-p-Ser536-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-29321-img0012.jpg" title="Functional (Inhibition): RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29321) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_lightbox"> <img src="//images.novusbio.com/images/RelA-NFkB-p65-p-Ser529-p-Ser536-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-29321-img0012.jpg" alt="Functional (Inhibition): RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set [NBP2-29321] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29321) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_thumb" /> </a> </div></div><div id="ss_next5" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-5" class="cycle-circle-pager"></div><div id="image-caption-NBP2-29321"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2003</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2003</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-29321","Product Name":"RelA\/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat, Bovine, Canine","Applications":"","Source":"","Purification":"","Immunogen":"Functions as a p65 decoy through phosphorylation of the Ser529\/536 sites on the peptide.","Citations":"13","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/rela-nfkb-p65-inhibitor_nbp2-29321\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/nfkb-p50-nls-inhibitor_nbp2-29323">NBP2-29323</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-29323" data-name="NFkB p50 (NLS) Inhibitor Peptide Set" data-position="7" class="ecommerce_link" href="/products/nfkb-p50-nls-inhibitor_nbp2-29323" title="NFkB p50 (NLS) Inhibitor Peptide Set" ><span> NFkB p50 (NLS) Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="12 Publications specific to this product" href="/products/nfkb-p50-nls-inhibitor_nbp2-29323#PublicationSection"><span class="publications"></span> (12 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-29323"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/nfkb-p50-nls-inhibitor_nbp2-29323">NBP2-29323</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-6" data-cycle-prev="#ss_prev6" data-cycle-next="#ss_next6" data-cycle-caption="#image-caption-NBP2-29323" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/NFkB-p105-p50-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-29323-img0001.jpg" title="Functional (Inhibition): NFkB p105/p50 Inhibitor Peptide Set [NBP2-29323] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29323) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_lightbox"> <img src="//images.novusbio.com/images/NFkB-p105-p50-Inhibitor-Peptide-Set-Functional-Inhibition-NBP2-29323-img0001.jpg" title="Functional (Inhibition): NFkB p105/p50 Inhibitor Peptide Set [NBP2-29323] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29323) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." alt="Functional (Inhibition): NFkB p105/p50 Inhibitor Peptide Set [NBP2-29323] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29323) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test)." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-NBP2-29323"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span>, <span title="Chicken">Ch</span>, <span title="Xenopus">Xp</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span>, <span title="Chicken">Ch</span>, <span title="Xenopus">Xp</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Inhibition Activity">Inhibition Activity</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2004</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2004</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-29323","Product Name":"NFkB p50 (NLS) Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse, Rat, Bovine, Canine, Chicken, Xenopus","Applications":"Inhibition Activity","Source":"","Purification":"","Immunogen":"Functions as a p50 decoy by blocking the intracellular recognition mechanism of p50 NLS.","Citations":"12","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/nfkb-p50-nls-inhibitor_nbp2-29323\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/ape1-redox-inhibitor_nbp1-49581">NBP1-49581</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP1-49581" data-name="APE1 Redox Inhibitor" data-position="8" class="ecommerce_link" href="/products/ape1-redox-inhibitor_nbp1-49581" title="APE1 Redox Inhibitor" ><span> APE1 Redox Inhibitor</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="13 Publications specific to this product" href="/products/ape1-redox-inhibitor_nbp1-49581#PublicationSection"><span class="publications"></span> (13 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>5 mg</strong><span class="product_price" data-sku="NBP1-49581"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/ape1-redox-inhibitor_nbp1-49581">NBP1-49581</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-7" data-cycle-prev="#ss_prev7" data-cycle-next="#ss_next7" data-cycle-caption="#image-caption-NBP1-49581" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/APE1-Redox-Inhibitor-NBP1-49581-img0002.jpg" title="APE1 Redox Inhibitor [NBP1-49581] - Chemical Structure of E3330 [NBP1-49581]" class="big_lightbox"> <img src="//images.novusbio.com/images/APE1-Redox-Inhibitor-NBP1-49581-img0002.jpg" title="APE1 Redox Inhibitor [NBP1-49581] - Chemical Structure of E3330 [NBP1-49581]" alt="APE1 Redox Inhibitor [NBP1-49581] - Chemical Structure of E3330 [NBP1-49581]" class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-NBP1-49581"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP1-49581","Product Name":"APE1 Redox Inhibitor","Description":"","Reactivity":"","Applications":"","Source":"","Purification":"","Immunogen":"","Citations":"13","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/ape1-redox-inhibitor_nbp1-49581\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/tirap-tlr2-and-tlr4-inhibitor_nbp2-26245">NBP2-26245</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-26245" data-name="TIRAP (TLR2 and TLR4) Inhibitor Peptide Set" data-position="9" class="ecommerce_link" href="/products/tirap-tlr2-and-tlr4-inhibitor_nbp2-26245" title="TIRAP (TLR2 and TLR4) Inhibitor Peptide Set" ><span> TIRAP (TLR2 and TLR4) Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="8 Publications specific to this product" href="/products/tirap-tlr2-and-tlr4-inhibitor_nbp2-26245#PublicationSection"><span class="publications"></span> (8 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1 mg</strong><span class="product_price" data-sku="NBP2-26245"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/tirap-tlr2-and-tlr4-inhibitor_nbp2-26245">NBP2-26245</a> </div><div id="ss_prev8" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-8" data-cycle-prev="#ss_prev8" data-cycle-next="#ss_next8" data-cycle-caption="#image-caption-NBP2-26245" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/TIRAP-TLR2-and-TLR4-Inhibitor-Peptide-NBP2-26245-img0007.jpg" title="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - TLR2 acts through formation of heterodimer complexes with TLR1 or TLR6. HEK 293 endogenously expresses TLR1 and TLR6, so that the TLR2 reporter cell line can response to both Pam3CSK4 (TLR2/TLR1 specific ligand) and MALP-2 (TLR2/TLR6 specific ligand). The TLR2 / TLR4 inhibitor specifically inhibits TLR2/TLR1 receptor complex activity in a dose-response manner but exhibited no or little effect on TLR2/TLR6 receptor complex activity." class="big_lightbox"> <img src="//images.novusbio.com/images/TIRAP-TLR2-and-TLR4-Inhibitor-Peptide-NBP2-26245-img0007.jpg" title="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - TLR2 acts through formation of heterodimer complexes with TLR1 or TLR6. HEK 293 endogenously expresses TLR1 and TLR6, so that the TLR2 reporter cell line can response to both Pam3CSK4 (TLR2/TLR1 specific ligand) and MALP-2 (TLR2/TLR6 specific ligand). The TLR2 / TLR4 inhibitor specifically inhibits TLR2/TLR1 receptor complex activity in a dose-response manner but exhibited no or little effect on TLR2/TLR6 receptor complex activity." alt="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - TLR2 acts through formation of heterodimer complexes with TLR1 or TLR6. HEK 293 endogenously expresses TLR1 and TLR6, so that the TLR2 reporter cell line can response to both Pam3CSK4 (TLR2/TLR1 specific ligand) and MALP-2 (TLR2/TLR6 specific ligand). The TLR2 / TLR4 inhibitor specifically inhibits TLR2/TLR1 receptor complex activity in a dose-response manner but exhibited no or little effect on TLR2/TLR6 receptor complex activity." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/TIRAP-TLR2-and-TLR4-Inhibitor-Peptide-NBP2-26245-img0008.jpg" title="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - The TLR4 reporter cell line responds to LPS. The TLR2 / TLR4 inhibitor specifically inhibits TLR4 activation upon LPS stimulation in a dose-response manner." class="big_lightbox"> <img src="//images.novusbio.com/images/TIRAP-TLR2-and-TLR4-Inhibitor-Peptide-NBP2-26245-img0008.jpg" alt="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - The TLR4 reporter cell line responds to LPS. The TLR2 / TLR4 inhibitor specifically inhibits TLR4 activation upon LPS stimulation in a dose-response manner." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/TIRAP-TLR2-and-TLR4-Inhibitor-Peptide-NBP2-26245-img0009.jpg" title="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - TLR2 /4 Inhibitor suppressed the Pam3CSK4-induced TLR2/TLR1 activity [A] and the LPS-induced TLR4 activity [B] in a dose-response manner, of which IC50 values were measured as 17.2 uM and 10.47 uM, respectively." class="big_lightbox"> <img src="//images.novusbio.com/images/TIRAP-TLR2-and-TLR4-Inhibitor-Peptide-NBP2-26245-img0009.jpg" alt="TIRAP (TLR2 and TLR4) Inhibitor Peptide [NBP2-26245] - TLR2 /4 Inhibitor suppressed the Pam3CSK4-induced TLR2/TLR1 activity [A] and the LPS-induced TLR4 activity [B] in a dose-response manner, of which IC50 values were measured as 17.2 uM and 10.47 uM, respectively." class="big_thumb" /> </a> </div></div><div id="ss_next8" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-8" class="cycle-circle-pager"></div><div id="image-caption-NBP2-26245"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2018</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2018</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-26245","Product Name":"TIRAP (TLR2 and TLR4) Inhibitor Peptide Set","Description":"","Reactivity":"Human, Mouse","Applications":"Flow, Func","Source":"","Purification":"","Immunogen":"","Citations":"8","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/tirap-tlr2-and-tlr4-inhibitor_nbp2-26245\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/glybenclamide-inhibitor_nbp2-30141">NBP2-30141</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-30141" data-name="Glybenclamide (NLRP3 Inhibitor)" data-position="10" class="ecommerce_link" href="/products/glybenclamide-inhibitor_nbp2-30141" title="Glybenclamide (NLRP3 Inhibitor)" ><span> Glybenclamide (NLRP3 Inhibitor)</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="7 Publications specific to this product" href="/products/glybenclamide-inhibitor_nbp2-30141#PublicationSection"><span class="publications"></span> (7 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1000 mg</strong><span class="product_price" data-sku="NBP2-30141"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/glybenclamide-inhibitor_nbp2-30141">NBP2-30141</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-9" data-cycle-prev="#ss_prev9" data-cycle-next="#ss_next9" data-cycle-caption="#image-caption-NBP2-30141" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Glybenclamide-NLRP3-Inhibitor-NBP2-30141-img0002.jpg" title="Glybenclamide (NLRP3 Inhibitor) [NBP2-30141] - Structure of the NLRP3 Inhibitor Glybenclamide: C23H28CIN3O5S" class="big_lightbox"> <img src="//images.novusbio.com/images/Glybenclamide-NLRP3-Inhibitor-NBP2-30141-img0002.jpg" title="Glybenclamide (NLRP3 Inhibitor) [NBP2-30141] - Structure of the NLRP3 Inhibitor Glybenclamide: C23H28CIN3O5S" alt="Glybenclamide (NLRP3 Inhibitor) [NBP2-30141] - Structure of the NLRP3 Inhibitor Glybenclamide: C23H28CIN3O5S" class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-NBP2-30141"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMI-2319</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMI-2319</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-30141","Product Name":"Glybenclamide (NLRP3 Inhibitor)","Description":"","Reactivity":"Human","Applications":"","Source":"","Purification":"","Immunogen":"","Citations":"7","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/glybenclamide-inhibitor_nbp2-30141\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/q-vd-oph-inhibitor_nbp2-29391">NBP2-29391</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-29391" data-name="Q-VD-OPH Inhibitor Peptide" data-position="11" class="ecommerce_link" href="/products/q-vd-oph-inhibitor_nbp2-29391" title="Q-VD-OPH Inhibitor Peptide" ><span> Q-VD-OPH Inhibitor Peptide</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="10 Publications specific to this product" href="/products/q-vd-oph-inhibitor_nbp2-29391#PublicationSection"><span class="publications"></span> (10 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1 mg</strong><span class="product_price" data-sku="NBP2-29391"></span> </div> </div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Functional Assay">Func</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Functional Assay">Func</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMI-2309-1</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMI-2309-1</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-29391","Product Name":"Q-VD-OPH Inhibitor Peptide","Description":"","Reactivity":"Human","Applications":"Func","Source":"","Purification":"","Immunogen":"Q-VD-OPH is a cell permeable caspase peptide inhibitor. Caspase inhibitors irreversibly bind to the catalytic site of caspase proteases and inhibit apoptosis. Caspase inhibitors may be broad spectrum, inhibiting multiple caspases, or may preferentially inhibit particular caspases. Z-VAD-FMK,<span class=\"compare_read_more_click\">...(read more)<\/span><span class=\"compare_read_more\"> BOC-D-FMK, and Q-VD-OPH are examples of broad spectrum or pan caspase inhibitors. In contrast Z-DEVD-FMK preferentially inhibits caspases 3 and 7, Z-IETD-FMK preferentially inhibits caspase 8, Z-LEHD-FMK preferentiailly inhibits caspase 9. Z-FA-FMK is considered to be a negative control for FMK based caspase inhibitors.<\/span>","Citations":"10","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/q-vd-oph-inhibitor_nbp2-29391\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/akt1-2-3-inhibitor_nbp2-29332">NBP2-29332</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-29332" data-name="AKT1/2/3 Inhibitor Peptide Set" data-position="12" class="ecommerce_link" href="/products/akt1-2-3-inhibitor_nbp2-29332" title="AKT1/2/3 Inhibitor Peptide Set" ><span> AKT1/2/3 Inhibitor Peptide Set</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/akt1-2-3-inhibitor_nbp2-29332#ReviewsSection"><span class="stars4"></span> (1 Review)</a> </div> <div class="segment"> <a title="2 Publications specific to this product" href="/products/akt1-2-3-inhibitor_nbp2-29332#PublicationSection"><span class="publications"></span> (2 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>2 mg</strong><span class="product_price" data-sku="NBP2-29332"></span> </div> </div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-2007</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-2007</div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-29332","Product Name":"AKT1\/2\/3 Inhibitor Peptide Set","Description":"","Reactivity":"Human","Applications":"","Source":"","Purification":"","Immunogen":"Functions as a TCL1 PH decoy by binding to Akt.","Citations":"2","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/akt1-2-3-inhibitor_nbp2-29332\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div></div><div class="lower_framework"> <div class="search_pager"><div class="searchImage_backGrey" style="display:inline-block;zoom:1;width:6px;height:11px;background:url(//resources.rndsystems.com/images/search/searchSprite03-31-16.png) -18px -169px"></div> page <input type="text" value="1" class="search_pager_text" data-url="/product-type/inhibitors?page="> of <span class="search_total_pages">3</span> <div class="search_page forward" style="display:inline-block;zoom:1"><a href="/product-type/inhibitors?page=2" rel="nofollow" class="active"><div class="searchImage_forward" style="display:inline-block;zoom:1;width:6px;height:11px;background:url(//resources.rndsystems.com/images/search/searchSprite03-31-16.png) -7px -152px"></div></a></div> </div></div><div id="product_skus" 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