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5 Foods to Maximize Brain Function
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367.84375 Z M 7.09375 7.09375 " fill="#000000"></path></defs><g><path d="M 187.46875 7.09375 C 87.851562 7.09375 7.09375 87.851562 7.09375 187.46875 C 7.09375 287.085938 87.851562 367.84375 187.46875 367.84375 C 287.085938 367.84375 367.84375 287.085938 367.84375 187.46875 C 367.84375 87.851562 287.085938 7.09375 187.46875 7.09375 " fill-opacity="1" fill-rule="nonzero" fill="#000000"></path></g><g transform="translate(85, 75)"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" version="1.1" height="215" width="215"><path d="M18.244 2.25h3.308l-7.227 8.26 8.502 11.24H16.17l-5.214-6.817L4.99 21.75H1.68l7.73-8.835L1.254 2.25H8.08l4.713 6.231zm-1.161 17.52h1.833L7.084 4.126H5.117z" fill="#ffffff"></path></svg> </g></svg></button><button aria-label="linkedin" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" 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c0.3,0.3,0.3,0.5,0.2,0.9c-0.1,0.3-0.3,1-0.3,1.3c-0.1,0.4-0.4,0.6-0.8,0.4c-2.2-0.9-3.3-3.4-3.3-6.1c0-4.5,3.8-10,11.4-10 c6.1,0,10.1,4.4,10.1,9.2c0,6.3-3.5,11-8.6,11c-1.7,0-3.4-0.9-3.9-2c0,0-0.9,3.7-1.1,4.4c-0.3,1.2-1,2.5-1.6,3.4 c1.4,0.4,3,0.7,4.5,0.7c8.8,0,16-7.2,16-16C48,23.2,40.8,16,32,16z" fill="white"></path></svg></button><button aria-label="email" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">For patients looking to supercharge their memory, what foods are best? </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><div class="relative"><div class="brightcove-fluid" autoplay=""></div></div><p class="pb-2">Patrick Porter, PhD, discusses the top 5 foods her recommends for brain function. </p><p class="pb-2"><strong>Dr Porter</strong> is author of several books, including <em>Awaken the Genius: Mind Technology for the 21stCentury.</em> <em>He has devoted his career to neuroscience and brainwave entrainment. Dr Porter is the founder of BrainTap Technologies, which offers digital tools and mind development apps to improve mental, physical, and emotional health. You can follow him @BrainTapTech on</em> <em><a rel="nofollow noreferrer noopener" target="_blank" href="https://www.facebook.com/braintaptech/">Facebook</a>,</em> <em><a rel="nofollow noreferrer noopener" target="_blank" href="https://www.instagram.com/braintaptech">Instagram</a>, and</em> <em><a rel="nofollow noreferrer noopener" target="_blank" href="https://twitter.com/BrainTapTech">Twitter</a>.</em></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit 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He has devoted his career to neuroscience and brainwave entrainment. Dr Porter is the founder of BrainTap Technologies, which offers digital tools and mind development apps to improve mental, physical, and emotional health. You can follow him @BrainTapTech on Facebook, Instagram, and Twitter.","description":"For patients looking to supercharge their memory, what foods are best? 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","_key":"e07c7b167a7e5"},{"text":"The full transcript is below.","_key":"d0c90873a168","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"75b9a7580082","markDefs":[{"_type":"link","href":"https://ascpp.org/ascp-meetings/ascp-annual-meeting/","_key":"47dc3b29b5f1","blank":true}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a6d54042b8100"}],"_type":"block","style":"normal","_key":"cff6d0b39b95"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I am Anita Clayton. I am professor and chair of psychiatry and neurobehavioral sciences at the University of Virginia. 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","_key":"264197a600d70"}],"_type":"block"},{"style":"normal","_key":"488c897a74e2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The instruments that were used are the Hamilton Depression Rating Scale (HAM-D), looking at the anxiety somatization score, and the Montgomery and Åsberg Depression Rating Scale (MADRS) total score, looking at depression and also looking at the anhedonia subscale with the MADRS.","_key":"d89a83aa6cfb"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think it is really exciting if we can see early improvements that inform us that this person will actually go on to achieve remission and functional recovery, as opposed to feeling like we have to wait 6 to 8 weeks before we know if we should change medications or not.","_key":"ee7fd95dea900"}],"_type":"block","style":"normal","_key":"269a930c4147"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"These are bipolar 1 patients in a depressive episode—so often, we do not always know that what we give them will lead them to be stable in terms of their mood. 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Goldberg, MD, ","_key":"f2cea23fae140"},{"_key":"f2cea23fae141","_type":"span","marks":["em"],"text":"joins Psychiatric Times"},{"text":"® live from ","_key":"f2cea23fae142","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"the ","_key":"f2cea23fae143"},{"_type":"span","marks":["33dc11632b55"],"text":"2024 American Society of Clinical Psychopharmacology (ASCP) Annual Meeting","_key":"f2cea23fae144"},{"_key":"f2cea23fae145","_type":"span","marks":[],"text":" and gives us a preview of his upcoming panel presentation, “Pseudospecific Versus Transdiagnostic Symptom Targeting in Pharmacotherapy Trials: Agitation, Attention, Anhedonia, and Mood Instability.” The full transcript is below."}],"_type":"block","style":"normal","_key":"569d20727a45"},{"style":"normal","_key":"b6be64dcc1a7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b05122c740070"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Hi, I am Dr Joseph Goldberg. I am a clinical professor of psychiatry at The Icahn School of Medicine at Mount Sinai in New York. And I am also the president of the ASCP.","_key":"647848258bc20"}],"_type":"block","style":"normal","_key":"7ed979438cc2"},{"_key":"fbc3eca0db5b","markDefs":[],"children":[{"marks":[],"text":"As part of the ASCP Annual Meeting, on Thursday, I am involved in a presentation about transdiagnostic vs pseudospecific features of psychopathology. Along with my colleagues, Drs Roger McIntyre, Manpreet Singh, and Justin Faden, as well as Dr Tiffany Farchioni from the FDA, will be talking about the ways in which certain target symptoms in clinical trials might represent either phenomena that cut across different diagnostic spectra and may not have pathognomonic or diagnosis-specific importance, but rather reflect broader underlying neural circuitry processes. ","_key":"a0bce0d2ab590","_type":"span"}],"_type":"block","style":"normal"},{"_key":"a48073532208","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We will then tease apart the ways in which some of those common psychopathology features may or may not reflect true, independent targets of treatment themselves, as opposed to the term ","_key":"8e96ac6e7d6d"},{"marks":["em"],"text":"pseudospecific phenomena","_key":"a0bce0d2ab591","_type":"span"},{"_type":"span","marks":[],"text":".","_key":"a0bce0d2ab592"}],"_type":"block","style":"normal"},{"_key":"55312f1e0cac","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Let me give an example. Let’s suppose you have pneumonia, and you are coughing quite a bit, and I target your cough with an antitussive medication. I help your cough, but I have not really treated your pneumonia. If we concluded that Robitussin was helpful, we would say it was pseudospecifically helpful in treating your cough. But that does not mean that every time you have a cough from any and all causes like allergies or airway obstructions, ","_key":"0db7ffbf0f220"},{"_type":"span","marks":["em"],"text":"let’s use Robitussin","_key":"0db7ffbf0f221"},{"_type":"span","marks":[],"text":". That would be an instance where we have a transdiagnostic symptom. Coughing happens in lots of different elements, but the treatments may differ depending on the etiology. So, that is where the pseudospecificity and the transdiagnostic features come into play.","_key":"0db7ffbf0f222"}],"_type":"block","style":"normal"},{"children":[{"_key":"7740f982407e0","_type":"span","marks":[],"text":"This Thursday, at our presentation, we are going to be talking about 4 particular kinds of either transdiagnostic or pseudospecific features:"}],"_type":"block","style":"normal","_key":"ce5a8a6867d1","markDefs":[]},{"_key":"1e16ed3fd5dd","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Anhedonia—the loss of the ability to feel pleasure","_key":"05308a6511db0"}],"level":1,"_type":"block","style":"normal"},{"level":1,"_type":"block","style":"normal","_key":"cdf485b932a2","listItem":"bullet","markDefs":[],"children":[{"marks":[],"text":"Cognition—cognitive processing, attentional processing, executive functioning, mood instability (that is, variations in mood from moment to moment. It is a term that we do not really formally identify in clinical trials, but it is something that, on a day-to-day basis, we often talk about with patients)","_key":"6909f8b56e3d0","_type":"span"}]},{"children":[{"_type":"span","marks":[],"text":"Variations in mood—consistency of mood provocation and of mood changes, and the extent to which our interventions specifically target mood instability","_key":"3d1ae62b67af0"}],"level":1,"_type":"block","style":"normal","_key":"77ab52b4bc76","listItem":"bullet","markDefs":[]},{"_key":"d681dbb09e2f","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Agitation, which is a very ubiquitous phenomenon, again, cutting across many disorders, from psychotic disorders, mania, and posttraumatic stress disorders to substance use disorders","_key":"bb9f0a7841580"}],"level":1,"_type":"block","style":"normal"},{"style":"normal","_key":"322db33f688b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8d1ffe8c548c0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"What can we learn about agitation in the context in which it arises? To what extent might there be particular interventions that we could call anti-agitation treatments that might work better in the context of psychosis, or that might work better in the context of a mood disorder or in the context of a substance use disorder? And how much should the clinician or the investigator or the practitioner really be thinking about what is the underlying etiology of 1 of these 4 symptoms—anhedonia, cognitive dysfunction, agitation, and mood instability? Because they are nonspecific, they do cut across diagnoses.","_key":"241a551772d60"}],"_type":"block","style":"normal","_key":"4cd505891733","markDefs":[]},{"_key":"861959e4009a","markDefs":[],"children":[{"text":"What we are really going to, in a panel fashion, is talk about the ways in which different manifestations of these phenomena may come up in these different contexts, and how some treatments may cut across broadly. There are certain classes of medicine that might be very broad treatments for mood instability, regardless of the diagnosis, and maybe others that are a little more specifically helpful when 1 of these core transdiagnostic symptoms occurs in a particular diagnostic setting.","_key":"68cb048a0eb2","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, the “stay tuned” portion of my presentation to you here is to hear more about the ways in which these kinds of symptoms present may reflect underlying neural circuitry disorders and cut across diagnoses. That is really the thrust of our presentation, and we hope to share information that will shed light on how to better treat patients with these kinds of transdiagnostic symptoms.","_key":"7efd360ae6c40"}],"_type":"block","style":"normal","_key":"a059d0d874e0"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Maybe as a final thought, let me just leave you with this notion. One of the things that ASCP is really committed to, as an organization, is not just identifying cutting-edge treatments and new technologies, but really understanding what it is we are treating when we approach psychopathology and different disorders. That goes beyond the DSM-5 categorization of disorders. It really brings us more toward understanding what we think is going on in the brain disorders of neural circuitry that involve mood regulation, attentional processing, executive functioning, impulse control, and aggression.","_key":"846d6216b1b00"}],"_type":"block","style":"normal","_key":"c4b5db0d6df6"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"These are all examples of brain circuitry gone awry, so this really is an opportunity to invite broader thinking about not just on-label uses of drugs for disorders, but targeting specific symptoms within certain contexts that we think is really getting more specifically what the underlying brain processes are. Hopefully we will be advancing knowledge in our clinical and critical thinking about brain disorders with examples such as this one from transdiagnostic and pseudospecific treatment targets.","_key":"290afa0672f80"}],"_type":"block","style":"normal","_key":"3ae980261d1b"},{"children":[{"_type":"span","marks":[],"text":"","_key":"8f206249bf2f0"}],"_type":"block","style":"normal","_key":"392d82a1a5a0","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Dr Goldberg","_key":"18dd39fd708a0"},{"text":" ","_key":"18dd39fd708a1","_type":"span","marks":[]},{"marks":["em"],"text":"is a clinical professor of psychiatry at The Mount Sinai School of Medicine and president of the ASCP.","_key":"18dd39fd708a2","_type":"span"}],"_type":"block","style":"normal","_key":"3c8498728dbb"},{"style":"normal","_key":"e558e979a130","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"954c7aafcb670"}],"_type":"block"},{"_type":"block","style":"normal","_key":"7fee572d8654","markDefs":[{"blank":true,"_type":"link","href":"https://www.psychiatrictimes.com/","_key":"7889cb96ef1b"}],"children":[{"_key":"a1378838baa20","_type":"span","marks":["em"],"text":"Follow the "},{"_type":"span","marks":[],"text":"Psychiatric Times ","_key":"000ba7bfa3f3"},{"_type":"span","marks":["em"],"text":"coverage of the 2024 ASCP Annual Meeting, and stay up-to-date on news related to research on promising new interventions and developments in the treatment of a wide variety of psychiatric disorders, at ","_key":"f1a1cb86df15"},{"_type":"span","marks":["7889cb96ef1b","em"],"text":"psychiatrictimes.com","_key":"a1378838baa21"},{"text":".","_key":"a1378838baa22","_type":"span","marks":["em"]}]},{"_type":"block","style":"normal","_key":"280f95b22ade","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8cd5a26235a4"}]}],"summary":"Joseph F. 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I am professor and chair of psychiatry and neurobehavioral Sciences at the University of Virginia. I am also professor of clinical obstetrics and gynecology in the UVA School of Medicine.","_key":"35ab05c2defc0"}],"_type":"block","style":"normal","_key":"184c0105d063"},{"style":"normal","_key":"3bbe03104126","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, we are here at the ASCP Annual Meeting in Florida with generally good, but pretty hot and humid, weather. So, maybe some people are staying indoors to listen to some of the presentations. We have had 1 poster session, and we will have another one tomorrow.","_key":"b13b8b9034650"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"157ae37a79570","_type":"span","marks":[],"text":"These topics look really exciting and interesting and are about various new potential treatments that have unique mechanisms of action—and are also looking at potentially new areas to be treated, so clinical conditions with something that is already approved for some other purpose. I think people are also looking at various other digital pharmacogenomic and a whole variety of other kinds of electronic or biologic measures and biomarkers here, too."}],"_type":"block","style":"normal","_key":"2a66d70c3afc"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think this could be very exciting, or at least the start of some really exciting possibilities because we all have unmet needs in all of our conditions, so we really do need some additional treatments to get our patients well and fully functional.","_key":"d0959cbe49f80"}],"_type":"block","style":"normal","_key":"93028b09072e"},{"_type":"block","style":"normal","_key":"eb3f8a4838db","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Participation in ASCP this year has been great. Lots of people are here. There is no virtual program, so people are here in person, interacting. 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It was focused on navigating new treatments for posttraumatic stress disorder (PTSD).","_key":"2d33a5b905180","_type":"span"}],"_type":"block","style":"normal","_key":"fd89319fabd5","markDefs":[]},{"children":[{"_key":"95b5f3eac2c70","_type":"span","marks":[],"text":"I had a really wonderful panel of speakers, including Dr Tom Neylan from the University of California, San Francisco, who gave an amazing talk on how much impact PTSD has on patients, their families, and on their occupational performance, and just the depth of how these symptoms related to having previously experienced a life-threatening trauma can impact and have very profound effects on people who have survived these kinds of life-threatening traumas."}],"_type":"block","style":"normal","_key":"090611bb2f66","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"That was followed by a wonderful talk by Susan Gurley, who is the executive director of the Anxiety and Depression Association of America. She is a staunch patient and family advocate, and her talk was beautiful: on looking at stigma as it relates to posttraumatic stress, stigma in society as well as self-stigma. ","_key":"a7cd5ca5a7ac0"}],"_type":"block","style":"normal","_key":"bd2b88126993","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"People who are recovering from posttraumatic stress carry around a lot of fear that they are going to be judged, marginalized, or even fired from a job. And this type of self-stigma is somewhat silent. Patients are afraid to talk about it with their friends or families, so it keeps some very isolated. We are hoping that that message gets out to have more public awareness and to help people be brave enough to seek treatment.","_key":"bc43fbdfa6b0"}],"_type":"block","style":"normal","_key":"14edc587ae96"},{"_key":"243cef6f1c8a","markDefs":[],"children":[{"text":"Now when it comes to treatment, we know that we have many things that are available, but they are not always as effective as we would like them to be. So, that is why we were so excited to have 2 speakers looking at some very new data on some treatment responses. ","_key":"54c0b8d72db80","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_key":"7ebc6e579061","markDefs":[],"children":[{"_type":"span","marks":[],"text":"First of all, Dr Adriana Feder from the Icahn School of Medicine at Mount Sinai gave a wonderful talk on intravenous (IV) ketamine in combination with written exposure therapy.","_key":"b29a2066ae90"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"She followed up on some randomized controlled trials that had been showing promise for IV ketamine. She had a small sample of women—this was an open-label study—but it is a promising pilot study. These women went through about 6 sessions of IV ketamine in combination with exposure therapy and really showed some profound improvement. Over half of those patients went on to be very responsive, and that response was sustained over a few months. So that is exciting and will be followed up on with more rigorous trials.","_key":"a9f02a4c06180"}],"_type":"block","style":"normal","_key":"95a178859a05"},{"_key":"71652cc9fd36","markDefs":[],"children":[{"marks":[],"text":"Our final session was very exciting, delivered by Saloni Behl from Otsuka Pharmaceuticals, and it was looking at 3 recent very large multi-site studies looking at brexpiprazole all in combination with sertraline. A little over 1200 individuals participated in these 3 large-scale studies, and it is just exciting. That brexpiprazole combined with sertraline came out to be much better than sertraline combined with placebo in 2 out of 3 of these studies. When you pull all the studies together, you still get this very important signal that the combination is superior to sertraline plus placebo.","_key":"cf627e1458860","_type":"span"}],"_type":"block","style":"normal"},{"style":"normal","_key":"1659f3397959","markDefs":[],"children":[{"text":"So, that is exciting. It is on the horizon, and we can continue to look at these results. We also have posters on that study looking at the safety, which is very good, and tolerability of the brexpiprazole-sertraline combination.","_key":"3f4f08aaf59f","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"text":"I am just really excited that we are having some breakthroughs in this somewhat stagnant world of psychopharmacology—new and better treatments and combinations. This gives patients alternatives and, actually, hope that they can recover from a very devastating mental condition. We are just thrilled that we had this space in the ASCP Annual Meeting and hope you were there to see it. Thank you.","_key":"7ca35cd78eec0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"ed0507d86478"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a3da57385ec20"}],"_type":"block","style":"normal","_key":"b8f7fe1723e1"},{"_type":"block","style":"normal","_key":"ce69dafff331","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Dr Davis ","_key":"e99e4cf5665a0"},{"_type":"span","marks":["em"],"text":"is a clinical professor of psychiatry in the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama Health System in Birmingham and Tuscaloosa, 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