Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes

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'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" 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class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="6STKGP6i1Ni3AB5ZRllJPveBEfgN9W8jHGAPg16yWMQsB0OCkYpgdNQE0xm4Q4rn"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" 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class="heading-title"> Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Galletti+G&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Giuseppe Galletti">Giuseppe Galletti</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Halima+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ahmed Halima">Ahmed Halima</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gjyrezi+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ada Gjyrezi">Ada Gjyrezi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+J&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jiaren Zhang">Jiaren Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zimmerman+B&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bob Zimmerman">Bob Zimmerman</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Worroll+D&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Daniel Worroll">Daniel Worroll</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kallergi+G&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Galatea Kallergi">Galatea Kallergi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Barreja+R&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rohan Barreja">Rohan Barreja</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ocean+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Allyson Ocean">Allyson Ocean</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Saxena+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ashish Saxena">Ashish Saxena</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McGraw+TE&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Timothy E McGraw">Timothy E McGraw</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nanus+DM&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="David M Nanus">David M Nanus</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Elemento+O&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Olivier Elemento">Olivier Elemento</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Altorki+NK&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nasser K Altorki">Nasser K Altorki</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Tagawa+ST&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott T Tagawa">Scott T Tagawa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Giannakakou+P&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Paraskevi Giannakakou">Paraskevi Giannakakou</a></span> </div> </div> </div> <div class="short-article-details"> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38947080</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC11213041&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11213041/" data-ga-category="full_text" data-ga-action="PMCID" > PMC11213041 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1101/2024.06.16.24309003&id_type=DOI" href="https://doi.org/10.1101/2024.06.16.24309003" data-ga-category="full_text" data-ga-action="DOI" > 10.1101/2024.06.16.24309003 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Giuseppe Galletti</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> medRxiv<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2024">2024</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/38947080/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button 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data-ga-category="search" data-ga-action="author_link" data-ga-label="Giuseppe Galletti">Giuseppe Galletti</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Halima+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ahmed Halima">Ahmed Halima</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gjyrezi+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ada Gjyrezi">Ada Gjyrezi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+J&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jiaren Zhang">Jiaren Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zimmerman+B&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bob Zimmerman">Bob Zimmerman</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Worroll+D&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Daniel Worroll">Daniel Worroll</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kallergi+G&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Galatea Kallergi">Galatea Kallergi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Barreja+R&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rohan Barreja">Rohan Barreja</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ocean+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Allyson Ocean">Allyson Ocean</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Saxena+A&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ashish Saxena">Ashish Saxena</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McGraw+TE&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Timothy E McGraw">Timothy E McGraw</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nanus+DM&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="David M Nanus">David M Nanus</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Elemento+O&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Olivier Elemento">Olivier Elemento</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Altorki+NK&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nasser K Altorki">Nasser K Altorki</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Tagawa+ST&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott T Tagawa">Scott T Tagawa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Giannakakou+P&cauthor_id=38947080" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Paraskevi Giannakakou">Paraskevi Giannakakou</a></span> </div> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38947080</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC11213041&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11213041/" data-ga-category="full_text" data-ga-action="PMCID" > PMC11213041 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1101/2024.06.16.24309003&id_type=DOI" href="https://doi.org/10.1101/2024.06.16.24309003" data-ga-category="full_text" data-ga-action="DOI" > 10.1101/2024.06.16.24309003 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/38947080/citations/" data-citation-style="nlm" data-pubmed-format-link="/38947080/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Circulating tumor cells (CTCs) captured from the bloodstream of patients with solid tumors have the potential to accelerate precision oncology by providing insight into tumor biology, disease progression and response to treatment. However, their potential is hampered by the lack of standardized CTC enrichment platforms across tumor types. EpCAM-based CTC enrichment, the most commonly used platform, is limited by EpCAM downregulation during metastasis and the low EpCAM expression in certain tumor types, including the highly prevalent and lethal NSCLC. In this study we demonstrate that Transferrin Receptor (TfR) is a selective, efficient biomarker for CTC identification and capture in patients with prostate, pancreatic and NSCLC. TfR identifies significantly higher CTC counts than EpCAM, and TfR <sup>+</sup> -CTC enumeration correlates with disease progression in metastatic prostate and pancreatic cancers, and overall survival and osimetrinib-resistance in non-small cell lung cancer (NSCLC). Profiling of TfR <sup>+</sup> -CTCs provides a snapshot of the molecular landscape of each respective tumor type and identifies potential mechanisms underlying treatment response to EGFR TKi and immune checkpoint inhibitors in NSCLC. </p> <p> <strong class="sub-title"> One sentence summary: </strong> Transferrin Receptor identifies circulating tumor cells in solid tumors. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/18687126/" ref="article_id=18687126&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="18687126" data-ga-label=""> Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Deng G, Herrler M, Burgess D, Manna E, Krag D, Burke JF.</span> <span class="docsum-authors short-authors">Deng G, et al.</span> <span class="docsum-journal-citation full-journal-citation">Breast Cancer Res. 2008;10(4):R69. doi: 10.1186/bcr2131. 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Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes - PubMed