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class="blocks"> <h1 class="title archive-month">Archive for <span class="altText">February, 2012</span></h1> <div class="divider"></div>  <div id="post-4586" class="hentry post post-1 odd author-cmarizzi category-g2conline post_tag-biosafety post_tag-dual-use-rsearch post_tag-flu post_tag-fouchier post_tag-h5n1 post_tag-influenza post_tag-kawaoka post_tag-nsabb post_tag-who clear-block"> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/29/update-catching-the-flu-between-complacency-and-fear/" rel="bookmark" title="Permanent Link: Update Catching the Flu: Between Complacency and Fear">Update Catching the Flu: Between Complacency and Fear</a></h2> <div class="post-date"> <p class="day">Feb 29th</p> </div> <div class="post-info clear-block "> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/cmarizzi/" title="Posts by Christine Marizzi ">Christine Marizzi</a> in <a href="http://blogs.dnalc.org/category/sitetopics/g2conline/">G2C Online</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/29/update-catching-the-flu-between-complacency-and-fear/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <a href="http://blogs.dnalc.org/wp-content/uploads/2012/01/Flu_full2.jpg"></a><p class="wp-caption-text">A model of the influenza virus. (Artwork by Holger Guggi, copyright by Reingard Grabherr and Florian Krammer.)</p> <p>Back in January, <a title="Catching the flu - between complacency and fear" href="http://blogs.dnalc.org/2012/01/25/catching-the-flu-between-complacency-and-fear/" target="_blank">I blogged</a> about how in December of 2011 the U.S. National Science Advisory Board for Biosecurity (NSABB) took the controversial step of requesting that the high-impact journals <em>Science</em> and <em>Nature</em> remove certain methodological details and the identity of the key mutations from the results to be published of <a href="../2012/01/25/catching-the-flu-between-complacency-and-fear/">two H5N1 avian influenza virus studies.</a> The reason for this drastic regulation? The NSABB classified their results as <a href="http://www.sciencemag.org/content/335/6069/662.full">“dual use” research</a> – research that could be used for either beneficial or ill-purposed applications. They raised concerns about the <a class="more-link" href="http://blogs.dnalc.org/2012/02/29/update-catching-the-flu-between-complacency-and-fear/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/biosafety/" rel="tag" title="biosafety (1 topics)">biosafety</a>, <a href="http://blogs.dnalc.org/tag/dual-use-rsearch/" rel="tag" title="dual use rsearch (1 topics)">dual use rsearch</a>, <a href="http://blogs.dnalc.org/tag/flu/" rel="tag" title="flu (2 topics)">flu</a>, <a href="http://blogs.dnalc.org/tag/fouchier/" rel="tag" title="fouchier (1 topics)">fouchier</a>, <a href="http://blogs.dnalc.org/tag/h5n1/" rel="tag" title="H5N1 (1 topics)">H5N1</a>, <a href="http://blogs.dnalc.org/tag/influenza/" rel="tag" title="influenza (2 topics)">influenza</a>, <a href="http://blogs.dnalc.org/tag/kawaoka/" rel="tag" title="kawaoka (1 topics)">kawaoka</a>, <a href="http://blogs.dnalc.org/tag/nsabb/" rel="tag" title="NSABB (1 topics)">NSABB</a>, <a href="http://blogs.dnalc.org/tag/who/" rel="tag" title="who (2 topics)">who</a> </div> </div>   <div id="post-4569" class="hentry post post-2 even alt author-cmarizzi category-g2conline post_tag-amp-kinase post_tag-ampk post_tag-couch-potato-gene post_tag-exercise post_tag-mice post_tag-mitochondria post_tag-model-organism clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/23/the-couch-potato-gene/"><img width="100" height="100" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/couchpotato1-100x100.jpg" class="attachment-post-thumbnail" alt="Credit: McMaster University" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/23/the-couch-potato-gene/" rel="bookmark" title="Permanent Link: The Couch Potato Gene">The Couch Potato Gene</a></h2> <div class="post-date"> <p class="day">Feb 23rd</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/cmarizzi/" title="Posts by Christine Marizzi ">Christine Marizzi</a> in <a href="http://blogs.dnalc.org/category/sitetopics/g2conline/">G2C Online</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/23/the-couch-potato-gene/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p>Next to the rarely true excuse, “Of course I´m not too heavy… I just have heavy bones,” the couch potato gene could be the perfect excuse for those who find exercise something of a chore. It may not be an attitude problem: ‘I’m not lazy, it’s my genes!’</p> <p>In investigating couch potatoes scientists have discovered why some of us have fun working out for hours while others lack energy and can barely summon the get-up-and-go to reach for the TV remote. </p> <p>They believe they have identified the genes that produce an enzyme in our muscles during work outs called AMP kinase <a class="more-link" href="http://blogs.dnalc.org/2012/02/23/the-couch-potato-gene/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/amp-kinase/" rel="tag" title="AMP kinase (1 topics)">AMP kinase</a>, <a href="http://blogs.dnalc.org/tag/ampk/" rel="tag" title="AMPK (2 topics)">AMPK</a>, <a href="http://blogs.dnalc.org/tag/couch-potato-gene/" rel="tag" title="couch potato gene (1 topics)">couch potato gene</a>, <a href="http://blogs.dnalc.org/tag/exercise/" rel="tag" title="exercise (1 topics)">exercise</a>, <a href="http://blogs.dnalc.org/tag/mice/" rel="tag" title="mice (1 topics)">mice</a>, <a href="http://blogs.dnalc.org/tag/mitochondria/" rel="tag" title="mitochondria (1 topics)">mitochondria</a>, <a href="http://blogs.dnalc.org/tag/model-organism/" rel="tag" title="model organism (1 topics)">model organism</a> </div> </div>   <div id="post-4564" class="hentry post post-3 odd author-opinedac category-dnabarcoding post_tag-anthropology post_tag-barcoding post_tag-dna post_tag-elephant post_tag-mammoth post_tag-mastodon post_tag-radiocarbon post_tag-sequencing clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/17/dna-sequencing-helps-discover-cavemen%e2%80%99s-tools-and-diet/"><img width="100" height="100" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/Mammut_skeleton_Museum_of_the_Earth-100x100.jpg" class="attachment-post-thumbnail" alt="Mammut_skeleton_Museum_of_the_Earth" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/17/dna-sequencing-helps-discover-cavemen%e2%80%99s-tools-and-diet/" rel="bookmark" title="Permanent Link: DNA sequencing helps discover cavemen’s tools and diet">DNA sequencing helps discover cavemen’s tools and diet</a></h2> <div class="post-date"> <p class="day">Feb 17th</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/opinedac/" title="Posts by Oscar Pineda-Catalan ">Oscar Pineda-Catalan</a> in <a href="http://blogs.dnalc.org/category/sitetopics/dnabarcoding/">DNA Barcoding</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/17/dna-sequencing-helps-discover-cavemen%e2%80%99s-tools-and-diet/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p>In the 1970s a team of archaeologists led by Carl Gustafson unearthed the remains of a single, 3-ton, male mastodon (<em>Mammut americanum</em>, a close relative of mammoths and elephants), hunted and butchered by a group of men at the Manis site in the state of Washington, USA (<a href="http://www.jstor.org/pss/41102203">Gustafson 1979</a>). Among the mastodon remains they found a spear point that pierced a rib bone. Luckily for us the hunters did not recover the projectile weapon. We thus have evidence of the technology that cavemen in the Americas used to secure their food.</p> <p>Originally Gustafson and his colleagues dated the mastodon hunting at <a class="more-link" href="http://blogs.dnalc.org/2012/02/17/dna-sequencing-helps-discover-cavemen%e2%80%99s-tools-and-diet/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/anthropology/" rel="tag" title="anthropology (2 topics)">anthropology</a>, <a href="http://blogs.dnalc.org/tag/barcoding/" rel="tag" title="barcoding (4 topics)">barcoding</a>, <a href="http://blogs.dnalc.org/tag/dna/" rel="tag" title="dna (36 topics)">dna</a>, <a href="http://blogs.dnalc.org/tag/elephant/" rel="tag" title="elephant (1 topics)">elephant</a>, <a href="http://blogs.dnalc.org/tag/mammoth/" rel="tag" title="mammoth (1 topics)">mammoth</a>, <a href="http://blogs.dnalc.org/tag/mastodon/" rel="tag" title="mastodon (1 topics)">mastodon</a>, <a href="http://blogs.dnalc.org/tag/radiocarbon/" rel="tag" title="radiocarbon (1 topics)">radiocarbon</a>, <a href="http://blogs.dnalc.org/tag/sequencing/" rel="tag" title="Sequencing (4 topics)">Sequencing</a> </div> </div>   <div id="post-4560" class="hentry post post-4 even alt author-cutillo category-yourgenesyourhealth post_tag-diversity post_tag-dna post_tag-gene post_tag-genetic-disease post_tag-lactose-intolerance post_tag-lactose-persistence post_tag-mutations post_tag-protein post_tag-selection post_tag-teaching clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/17/evolution-got-milk/"><img width="100" height="100" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/milk-100x100.jpg" class="attachment-post-thumbnail wp-post-image" alt="milk" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/17/evolution-got-milk/" rel="bookmark" title="Permanent Link: Evolution – Got Milk?">Evolution – Got Milk?</a></h2> <div class="post-date"> <p class="day">Feb 17th</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/cutillo/" title="Posts by Jennifer Galasso ">Jennifer Galasso</a> in <a href="http://blogs.dnalc.org/category/sitetopics/yourgenesyourhealth/">Your Genes, Your Health</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/17/evolution-got-milk/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p>After asking students during a lesson on mutations if it is possible that a mutation in DNA could be good, most students will nod yes without much understanding. Recently, I finally had one student raise his hand immediately and answer the question (with extreme surprise that no other students were blurting out the answer)…”evolution!” He was able to make the connection between changes in DNA that are building up over time, and how that change can possibly make that organism better in some way. If it helps the survival of an organism, that mutation is going to stick around and <a class="more-link" href="http://blogs.dnalc.org/2012/02/17/evolution-got-milk/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/diversity/" rel="tag" title="diversity (3 topics)">diversity</a>, <a href="http://blogs.dnalc.org/tag/dna/" rel="tag" title="dna (36 topics)">dna</a>, <a href="http://blogs.dnalc.org/tag/gene/" rel="tag" title="gene (11 topics)">gene</a>, <a href="http://blogs.dnalc.org/tag/genetic-disease/" rel="tag" title="genetic disease (7 topics)">genetic disease</a>, <a href="http://blogs.dnalc.org/tag/lactose-intolerance/" rel="tag" title="lactose intolerance (1 topics)">lactose intolerance</a>, <a href="http://blogs.dnalc.org/tag/lactose-persistence/" rel="tag" title="lactose persistence (1 topics)">lactose persistence</a>, <a href="http://blogs.dnalc.org/tag/mutations/" rel="tag" title="mutations (5 topics)">mutations</a>, <a href="http://blogs.dnalc.org/tag/protein/" rel="tag" title="protein (3 topics)">protein</a>, <a href="http://blogs.dnalc.org/tag/selection/" rel="tag" title="selection (1 topics)">selection</a>, <a href="http://blogs.dnalc.org/tag/teaching/" rel="tag" title="teaching (9 topics)">teaching</a> </div> </div>   <div id="post-4547" class="hentry post post-5 odd author-nisselle category-insidecancer post_tag-antibodies post_tag-cancer post_tag-dna post_tag-harvard post_tag-immune-system post_tag-nanorobot post_tag-nanotechnology post_tag-origami clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/17/what-do-you-get-when-you-cross-an-immunologist-with-a-nanotechnologist-and-a-geneticist-a-dna-nano-robot/"><img width="100" height="100" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/120116-NanoRobotPhoto-hmed-1215p.grid-6x2-100x100.jpg" class="attachment-post-thumbnail wp-post-image" alt="DNA nano-robot" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/17/what-do-you-get-when-you-cross-an-immunologist-with-a-nanotechnologist-and-a-geneticist-a-dna-nano-robot/" rel="bookmark" title="Permanent Link: What do you get when you cross an immunologist, a nanotechnologist, and a geneticist? A DNA nano-robot!">What do you get when you cross an immunologist, a nanotechnologist, and a geneticist? A DNA nano-robot!</a></h2> <div class="post-date"> <p class="day">Feb 17th</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/nisselle/" title="Posts by Amy Nisselle ">Amy Nisselle</a> in <a href="http://blogs.dnalc.org/category/sitetopics/insidecancer/">Inside Cancer</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/17/what-do-you-get-when-you-cross-an-immunologist-with-a-nanotechnologist-and-a-geneticist-a-dna-nano-robot/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p><em><strong>Welcome to the world of nanobiotechnology and translational research…</strong></em></p> <p>In a brilliant example of multidisciplinary research, <a title="Wyss Institute for Biologically Inspired Engineering" href="http://wyss.harvard.edu/" target="_blank">Harvard Medical School’</a>s Shawn Douglas, Ido Bachelet, and George Church combined forces to build nanostructures that would mimic the body’s immune system to recognize cancer cells and trick them into self-destructing. Their research is published today in <a title="A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads" href="http://www.sciencemag.org/content/335/6070/831.abstract" target="_blank">Science</a> but the discovery didn’t just happen overnight. It’s the culmination of several key discoveries going back several years, by researchers around the globe.</p> <p>In 2006, Paul Rothemund at the <a title="California Institute of Technology" href="http://www.caltech.edu/" target="_blank">California Institute of Technology</a>, discovered “<a title="Folding DNA to Create Nanoscale Shapes and Patterns" href="http://www.nature.com/nature/journal/v440/n7082/index.html" target="_blank">DNA origami</a>,” where the Watson-Crick base-pairing rules are exploited to create molecules from viral DNA <a class="more-link" href="http://blogs.dnalc.org/2012/02/17/what-do-you-get-when-you-cross-an-immunologist-with-a-nanotechnologist-and-a-geneticist-a-dna-nano-robot/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/antibodies/" rel="tag" title="antibodies (2 topics)">antibodies</a>, <a href="http://blogs.dnalc.org/tag/cancer/" rel="tag" title="Cancer (25 topics)">Cancer</a>, <a href="http://blogs.dnalc.org/tag/dna/" rel="tag" title="dna (36 topics)">dna</a>, <a href="http://blogs.dnalc.org/tag/harvard/" rel="tag" title="Harvard (1 topics)">Harvard</a>, <a href="http://blogs.dnalc.org/tag/immune-system/" rel="tag" title="immune system (2 topics)">immune system</a>, <a href="http://blogs.dnalc.org/tag/nanorobot/" rel="tag" title="nanorobot (1 topics)">nanorobot</a>, <a href="http://blogs.dnalc.org/tag/nanotechnology/" rel="tag" title="nanotechnology (2 topics)">nanotechnology</a>, <a href="http://blogs.dnalc.org/tag/origami/" rel="tag" title="origami (1 topics)">origami</a> </div> </div>   <div id="post-4537" class="hentry post post-6 even alt author-mcbrien category-dnafromthebeginning post_tag-dna post_tag-evolution post_tag-genes post_tag-hibernation post_tag-natural-selection post_tag-sleep clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/16/hibernation-why-not-me/"><img width="100" height="100" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/Bear_hibernating-100x100.jpg" class="attachment-post-thumbnail" alt="Bear_hibernating" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/16/hibernation-why-not-me/" rel="bookmark" title="Permanent Link: Hibernation – Why Not Me?">Hibernation – Why Not Me?</a></h2> <div class="post-date"> <p class="day">Feb 16th</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/mcbrien/" title="Posts by Amanda McBrien ">Amanda McBrien</a> in <a href="http://blogs.dnalc.org/category/sitetopics/dnafromthebeginning/">DNA From The Beginning</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/16/hibernation-why-not-me/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p><a href="http://blogs.dnalc.org/wp-content/uploads/2012/02/Bear_hibernating4.jpg"></a>It’s the season of hibernation, something I’ve always wished I could do. Oh, to wrap up in a ball, sleep away the winter, and wake to a beautiful spring day – like Bambi! Although the thought has always intrigued me, it never really occurred to me what a feat hibernation actually is. It turns out that all of the bears, squirrels, rabbits etc…. that I thought were just sleeping, are breaking biological laws!! If I was to stay dormant for 5 months, without food or drink and little to no movement in freezing temperatures I would die, so no hibernating <a class="more-link" href="http://blogs.dnalc.org/2012/02/16/hibernation-why-not-me/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/dna/" rel="tag" title="dna (36 topics)">dna</a>, <a href="http://blogs.dnalc.org/tag/evolution/" rel="tag" title="Evolution (9 topics)">Evolution</a>, <a href="http://blogs.dnalc.org/tag/genes/" rel="tag" title="genes (11 topics)">genes</a>, <a href="http://blogs.dnalc.org/tag/hibernation/" rel="tag" title="hibernation (1 topics)">hibernation</a>, <a href="http://blogs.dnalc.org/tag/natural-selection/" rel="tag" title="natural selection (3 topics)">natural selection</a>, <a href="http://blogs.dnalc.org/tag/sleep/" rel="tag" title="sleep (4 topics)">sleep</a> </div> </div>   <div id="post-4533" class="hentry post post-7 odd author-jwatkins category-yourgenesyourhealth post_tag-agouti post_tag-cancer post_tag-diet post_tag-dna post_tag-epigenetics post_tag-epigenetics-nutrition post_tag-inheritance post_tag-methylation post_tag-obesity post_tag-variable-regulation clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/16/controlling-gene-expression-through-diet/"><img width="100" height="100" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/1-dna-strands-100x100.jpg" class="attachment-post-thumbnail" alt="1 dna-strands" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/16/controlling-gene-expression-through-diet/" rel="bookmark" title="Permanent Link: Controlling gene expression through diet">Controlling gene expression through diet</a></h2> <div class="post-date"> <p class="day">Feb 16th</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/jwatkins/" title="Posts by Jermel Watkins ">Jermel Watkins</a> in <a href="http://blogs.dnalc.org/category/sitetopics/yourgenesyourhealth/">Your Genes, Your Health</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/16/controlling-gene-expression-through-diet/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p><a href="http://blogs.dnalc.org/wp-content/uploads/2012/02/1-dna-strands.jpg"></a>Epigenetics is the study of chemical reactions that control the on and off switch of genes at specific times and the factors influencing them. Environment is a factor that influences epigenetic change which may encompass behavior, stress or diet. The easiest of the three to make observations from is diet. When we think of food, rarely do we think of chemical modifications to DNA and restriction of gene activity. Commonly we think of foods coming in and being broken down into nutrients to be utilized in metabolic pathways to make components the body can use. Interestingly one of the pathways <a class="more-link" href="http://blogs.dnalc.org/2012/02/16/controlling-gene-expression-through-diet/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/agouti/" rel="tag" title="agouti (1 topics)">agouti</a>, <a href="http://blogs.dnalc.org/tag/cancer/" rel="tag" title="Cancer (25 topics)">Cancer</a>, <a href="http://blogs.dnalc.org/tag/diet/" rel="tag" title="diet (2 topics)">diet</a>, <a href="http://blogs.dnalc.org/tag/dna/" rel="tag" title="dna (36 topics)">dna</a>, <a href="http://blogs.dnalc.org/tag/epigenetics/" rel="tag" title="Epigenetics (4 topics)">Epigenetics</a>, <a href="http://blogs.dnalc.org/tag/epigenetics-nutrition/" rel="tag" title="epigenetics & nutrition (1 topics)">epigenetics & nutrition</a>, <a href="http://blogs.dnalc.org/tag/inheritance/" rel="tag" title="Inheritance (18 topics)">Inheritance</a>, <a href="http://blogs.dnalc.org/tag/methylation/" rel="tag" title="Methylation (3 topics)">Methylation</a>, <a href="http://blogs.dnalc.org/tag/obesity/" rel="tag" title="obesity (2 topics)">obesity</a>, <a href="http://blogs.dnalc.org/tag/variable-regulation/" rel="tag" title="variable regulation (1 topics)">variable regulation</a> </div> </div>   <div id="post-4529" class="hentry post post-8 even alt author-williams category-g2conline post_tag-alzhimers post_tag-apoe post_tag-beta-amyloid post_tag-drug post_tag-drug-target post_tag-treatment clear-block"> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/13/new-hope-for-alzheimers-sufferers/" rel="bookmark" title="Permanent Link: New Hope for Alzheimer’s Sufferers">New Hope for Alzheimer’s Sufferers</a></h2> <div class="post-date"> <p class="day">Feb 13th</p> </div> <div class="post-info clear-block "> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/williams/" title="Posts by Jason Williams ">Jason Williams</a> in <a href="http://blogs.dnalc.org/category/sitetopics/g2conline/">G2C Online</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/13/new-hope-for-alzheimers-sufferers/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p>This <a href="http://www.sciencemag.org/content/early/2012/02/08/science.1217697" target="_blank">article in science</a> is good news for suffers of Alzheimer’s. A group out of Case Western University reports that the drug <a href="http://en.wikipedia.org/wiki/Bexarotene" target="_blank">Bexarotene</a> can reverse the symptoms of Alzheimer’s in mouse models of the disease.</p> <p>More importantly, Bexarotene is already in use in human patients, making it easier to determine if the drug will have similar benefits for Alzheimer’s patients.</p> <p>According to Alzheimer’s Foundation statistics, 5.4 million Americans suffer from this debilitating disease. Alzheimer’s devastates patient’s cognitive abilities, with the most notable symptom being profound and worsening memory loss. While some amount of memory loss is to be expected with old age, Alzheimer’s patients <a class="more-link" href="http://blogs.dnalc.org/2012/02/13/new-hope-for-alzheimers-sufferers/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/alzhimers/" rel="tag" title="Alzhimer's (1 topics)">Alzhimer's</a>, <a href="http://blogs.dnalc.org/tag/apoe/" rel="tag" title="ApoE (1 topics)">ApoE</a>, <a href="http://blogs.dnalc.org/tag/beta-amyloid/" rel="tag" title="beta-amyloid (1 topics)">beta-amyloid</a>, <a href="http://blogs.dnalc.org/tag/drug/" rel="tag" title="drug (2 topics)">drug</a>, <a href="http://blogs.dnalc.org/tag/drug-target/" rel="tag" title="drug target (1 topics)">drug target</a>, <a href="http://blogs.dnalc.org/tag/treatment/" rel="tag" title="treatment (10 topics)">treatment</a> </div> </div>   <div id="post-4513" class="hentry post post-9 odd author-nash category-insidecancer post_tag-angiogenesis post_tag-biology post_tag-blood-vessels post_tag-breast post_tag-cancer post_tag-drugs clear-block"> <a class="post-thumb size-post-thumbnail alignleft" href="http://blogs.dnalc.org/2012/02/06/tumor-treatment-whether-to-shrink-or-not-to-shrink/"><img width="72" height="72" src="http://blogs.dnalc.org/wp-content/uploads/2012/02/angio.jpg" class="attachment-post-thumbnail" alt="angio" /></a> <h2 class="title"><a href="http://blogs.dnalc.org/2012/02/06/tumor-treatment-whether-to-shrink-or-not-to-shrink/" rel="bookmark" title="Permanent Link: Tumor Treatment: Whether to Shrink or Not to Shrink">Tumor Treatment: Whether to Shrink or Not to Shrink</a></h2> <div class="post-date"> <p class="day">Feb 6th</p> </div> <div class="post-info clear-block with-thumbs"> <p class="author alignleft">Posted by <a href="http://blogs.dnalc.org/author/nash/" title="Posts by Bruce Nash ">Bruce Nash</a> in <a href="http://blogs.dnalc.org/category/sitetopics/insidecancer/">Inside Cancer</a> </p> <p class="comments alignright"><a href="http://blogs.dnalc.org/2012/02/06/tumor-treatment-whether-to-shrink-or-not-to-shrink/#comments" class="no comments">No comments</a></p> </div> <div class="post-content clear-block"> <p>Just like normal tissue, tumors need blood vessels to grow. Because of this, drugs that stop angiogenesis, or the formation of new blood vessels, are one important approach to treating cancers. These angiogenesis inhibitors stop tumor growth by starving them of oxygen and nutrients, usually by interfering with signals from the tumor cells that promote blood vessel formation in the surrounding tissue. Angiog<a href="http://blogs.dnalc.org/wp-content/uploads/2012/02/angio.jpg"></a>enesis inhibitors have been shown to be effective in the treatment of several cancer types, but the results aren’t always as expected. Several recent studies show how complicated this can be. For instance, FDA approval of the drug <a class="more-link" href="http://blogs.dnalc.org/2012/02/06/tumor-treatment-whether-to-shrink-or-not-to-shrink/">More ></a></p> </div> <div class="post-tags"> <a href="http://blogs.dnalc.org/tag/angiogenesis/" rel="tag" title="angiogenesis (1 topics)">angiogenesis</a>, <a href="http://blogs.dnalc.org/tag/biology/" rel="tag" title="biology (4 topics)">biology</a>, <a href="http://blogs.dnalc.org/tag/blood-vessels/" rel="tag" title="blood vessels (1 topics)">blood vessels</a>, <a href="http://blogs.dnalc.org/tag/breast/" rel="tag" title="breast (1 topics)">breast</a>, <a href="http://blogs.dnalc.org/tag/cancer/" rel="tag" title="Cancer (25 topics)">Cancer</a>, <a href="http://blogs.dnalc.org/tag/drugs/" rel="tag" title="drugs (4 topics)">drugs</a> </div> </div>  </div> </div>  <div id="sidebar"> <ul class="blocks"> <li class="block"><div class="block-widget_search clear-block" id="instance-search-3">  <div class="search-form"> <form method="get" 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href='http://blogs.dnalc.org/tag/2009/' class='tag-link-558' title='3 topics' style='font-size: 8pt;'>2009</a> <a href='http://blogs.dnalc.org/tag/alzheimers/' class='tag-link-573' title='7 topics' style='font-size: 12.329896907216pt;'>Alzheimer's</a> <a href='http://blogs.dnalc.org/tag/autism/' class='tag-link-594' title='10 topics' style='font-size: 14.350515463918pt;'>autism</a> <a href='http://blogs.dnalc.org/tag/barcoding/' class='tag-link-1582' title='4 topics' style='font-size: 9.4432989690722pt;'>barcoding</a> <a href='http://blogs.dnalc.org/tag/biology/' class='tag-link-608' title='4 topics' style='font-size: 9.4432989690722pt;'>biology</a> <a href='http://blogs.dnalc.org/tag/brain/' class='tag-link-618' title='19 topics' style='font-size: 18.103092783505pt;'>brain</a> <a href='http://blogs.dnalc.org/tag/cancer/' class='tag-link-535' title='25 topics' style='font-size: 19.690721649485pt;'>Cancer</a> <a href='http://blogs.dnalc.org/tag/disease/' class='tag-link-688' title='13 topics' style='font-size: 15.938144329897pt;'>disease</a> <a href='http://blogs.dnalc.org/tag/dna/' class='tag-link-692' title='36 topics' style='font-size: 22pt;'>dna</a> <a href='http://blogs.dnalc.org/tag/drugs/' class='tag-link-704' title='4 topics' style='font-size: 9.4432989690722pt;'>drugs</a> <a href='http://blogs.dnalc.org/tag/education/' class='tag-link-540' title='6 topics' style='font-size: 11.60824742268pt;'>Education</a> <a href='http://blogs.dnalc.org/tag/epigenetics/' class='tag-link-713' title='4 topics' style='font-size: 9.4432989690722pt;'>Epigenetics</a> <a href='http://blogs.dnalc.org/tag/eugenics/' class='tag-link-541' title='14 topics' style='font-size: 16.371134020619pt;'>eugenics</a> <a href='http://blogs.dnalc.org/tag/evolution/' class='tag-link-542' title='9 topics' style='font-size: 13.773195876289pt;'>Evolution</a> <a href='http://blogs.dnalc.org/tag/gene/' class='tag-link-744' title='11 topics' style='font-size: 14.927835051546pt;'>gene</a> <a 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class='tag-link-893' title='3 topics' style='font-size: 8pt;'>Nobel</a> <a href='http://blogs.dnalc.org/tag/nobel-prize/' class='tag-link-548' title='3 topics' style='font-size: 8pt;'>Nobel prize</a> <a href='http://blogs.dnalc.org/tag/pharmacogenomics/' class='tag-link-919' title='4 topics' style='font-size: 9.4432989690722pt;'>Pharmacogenomics</a> <a href='http://blogs.dnalc.org/tag/prevention/' class='tag-link-550' title='4 topics' style='font-size: 9.4432989690722pt;'>Prevention</a> <a href='http://blogs.dnalc.org/tag/research/' class='tag-link-551' title='4 topics' style='font-size: 9.4432989690722pt;'>Research</a> <a href='http://blogs.dnalc.org/tag/schizophrenia/' class='tag-link-970' title='8 topics' style='font-size: 13.051546391753pt;'>schizophrenia</a> <a href='http://blogs.dnalc.org/tag/sequencing/' class='tag-link-978' title='4 topics' style='font-size: 9.4432989690722pt;'>Sequencing</a> <a href='http://blogs.dnalc.org/tag/sleep/' class='tag-link-990' title='4 topics' 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Tests as a Measure of Intelligence <span class="details inline">(1)</span></span></a></li> <li><a class="fadeThis" href="http://blogs.dnalc.org/2011/10/15/aids-cure-update/" rel="bookmark" title="AIDS Cure UPDATE"><span class="entry">AIDS Cure UPDATE <span class="details inline">(1)</span></span></a></li> </ul> </div> </div> </div> <div class="box section" id="sidebartabswidget-3-section-recentcomments"> <div class="box-top-left"><div class="box-top-right"></div></div> <div class="box-main"> <div class="box-content"> <ul class="menuList recentcomm"> <li class="clear-block"><a title="Posted in: DNA DAY 2010: What, me worry about my DNA?" class="fadeThis" href="http://blogs.dnalc.org/2010/04/29/dna-day-2010-what-me-worry-about-my-dna/#comment-8491"><span class="avatar"><img alt='' src='http://1.gravatar.com/avatar/d378d3a40a3590dd63b538282ae6b78a?s=32&d=http%3A%2F%2F1.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">Mohammed Khalfan: <span class="details"> Hi Traci, you should check this website out http://www.23andme.com/ - just might be what you're...</span></span></a></li> <li class="clear-block"><a title="Posted in: IQ Tests as a Measure of Intelligence" class="fadeThis" href="http://blogs.dnalc.org/2011/09/28/iq-tests-as-a-measure-of-intelligence/#comment-5440"><span class="avatar"><img alt='' src='http://0.gravatar.com/avatar/6b23915f2fdd2da3dc5c657112de54a5?s=32&d=http%3A%2F%2F0.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">Sue: <span class="details"> I agree. IQ tests are overated. They are based on assumptions about the nature of intelligence,...</span></span></a></li> <li class="clear-block"><a title="Posted in: Cancer Overtreatment. When the solution is worse than the problem." class="fadeThis" href="http://blogs.dnalc.org/2011/12/13/cancer-overtreatment-when-the-solution-is-worse-than-the-problem/#comment-5439"><span class="avatar"><img alt='' src='http://0.gravatar.com/avatar/ad516503a11cd5ca435acc9bb6523536?s=32' class='avatar avatar-32 photo avatar-default' height='32' width='32' /></span><span class="entry">points of view: <span class="details"> On My Twitter Feed... Then I checked my personal feed and saw somebody posting the link to the...</span></span></a></li> <li class="clear-block"><a title="Posted in: Tag…You’re It!" class="fadeThis" href="http://blogs.dnalc.org/2012/01/19/tag-youre-it/#comment-5359"><span class="avatar"><img alt='' src='http://1.gravatar.com/avatar/52935aba909ed59a5789008268b14fdb?s=32&d=http%3A%2F%2F1.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">talha: <span class="details"> the wonders of science i wanna be performing this epigenetic tag therapy.</span></span></a></li> <li class="clear-block"><a title="Posted in: Merry Christmas to Hemophilia Patients" class="fadeThis" href="http://blogs.dnalc.org/2011/12/15/merry-christmas-to-hemophilia-patients/#comment-5358"><span class="avatar"><img alt='' src='http://1.gravatar.com/avatar/52935aba909ed59a5789008268b14fdb?s=32&d=http%3A%2F%2F1.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">talha: <span class="details"> this is just a tip of an iceberg whats gonna happen more and more can only be expected from gene...</span></span></a></li> <li class="clear-block"><a title="Posted in: DNA DAY 2010: What, me worry about my DNA?" class="fadeThis" href="http://blogs.dnalc.org/2010/04/29/dna-day-2010-what-me-worry-about-my-dna/#comment-4616"><span class="avatar"><img alt='' src='http://1.gravatar.com/avatar/fe0f32261332c54b99b24c06881c2573?s=32&d=http%3A%2F%2F1.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">Traci: <span class="details"> How would I go about getting my DNA tested? Being an adopted child, we have exhausted legal alleys...</span></span></a></li> <li class="clear-block"><a title="Posted in: AIDS Cure UPDATE" class="fadeThis" href="http://blogs.dnalc.org/2011/10/15/aids-cure-update/#comment-1607"><span class="avatar"><img alt='' src='http://1.gravatar.com/avatar/997a441b2802e625590c2adc4ea2545f?s=32&d=http%3A%2F%2F1.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">Heaven: <span class="details"> This is really amazing. This is just another step to curing some of the most devastating diseases...</span></span></a></li> <li class="clear-block"><a title="Posted in: Compulsive Hoarding" class="fadeThis" href="http://blogs.dnalc.org/2011/11/10/compulsive-hoarding/#comment-1245"><span class="avatar"><img alt='' src='http://0.gravatar.com/avatar/cf95176c58575d503b402764e9710135?s=32&d=http%3A%2F%2F0.gravatar.com%2Favatar%2Fad516503a11cd5ca435acc9bb6523536%3Fs%3D32&r=G' class='avatar avatar-32 photo' height='32' width='32' /></span><span class="entry">Eileen @ Space Matters: <span class="details"> You've got some very interesting info here! Here's some places to go to get do some more...</span></span></a></li> </ul> </div> </div> </div> </div> </div>  </div></li><li class="block"><div class="block-twitter clear-block" id="instance-twitterwidget-3"><h3 class="title"><span>DNALC Twitter Feed</span></h3><div class="block-div"></div><div class="block-div-arrow"></div> <div class="twitter-content clear-block" id="twitterwidget-3"> <script type="text/javascript"> /* <![CDATA[ */ // init jQuery(document).ready(function(){ jQuery.ajax({ // load tweets trough ajax to avoid waiting for twitter's response type: "GET",url: "http://blogs.dnalc.org",data: { widget_id: '3', twituser: 'dnalc', twitcount: '4', get_twitter_data: 1 }, beforeSend: function() {jQuery("#twitterwidget-3 .loading").show("slow");}, complete: function() { jQuery("#twitterwidget-3 .loading").hide("fast");}, success: function(html){ jQuery("#twitterwidget-3").html(html); jQuery("#twitterwidget-3").show("slow"); } }); }); /* ]]> */ </script> <div class="loading">Loading tweets...</div> </div> <a class="followMe" href="http://www.twitter.com/dnalc"><span>Follow me on Twitter!</span></a> </div></li><li class="block"><div class="block-jetpack_subscription_widget clear-block" id="instance-blog_subscription-3"><h3 class="title"><span><label for="subscribe-field">Subscribe to Blog via Email</label></span></h3><div class="block-div"></div><div class="block-div-arrow"></div> <a name="subscribe-blog"></a> <form action="" method="post" accept-charset="utf-8" id="subscribe-blog"> <p>Enter your email address to subscribe to this blog and receive notifications of new posts by email.</p> <p><input type="text" name="email" style="width: 95%; padding: 1px 2px" value="Email Address" id="subscribe-field" onclick="if ( this.value == 'Email Address' ) { this.value = ''; }" onblur="if ( this.value == '' ) { this.value = 'Email Address'; }" /></p> <p> <input type="hidden" name="action" value="subscribe" /> <input type="hidden" name="source" value="http://blogs.dnalc.org/2012/02/" /> <input type="hidden" name="sub-type" value="widget" /> <input type="hidden" name="redirect_fragment" value="blog_subscription-3" /> <input type="hidden" id="_wpnonce" name="_wpnonce" value="4970eaa129" /> <input type="submit" value="Subscribe" name="jetpack_subscriptions_widget" /> </p> </form> </div></li><li class="block"><div class="block-widget_meta clear-block" id="instance-meta-3"><h3 class="title"><span>Meta</span></h3><div class="block-div"></div><div class="block-div-arrow"></div> <ul> <li><a href="http://blogs.dnalc.org/wp-login.php">Log in</a></li> <li><a href="http://blogs.dnalc.org/feed/" title="Syndicate this site using RSS 2.0">Entries <abbr title="Really Simple Syndication">RSS</abbr></a></li> <li><a href="http://blogs.dnalc.org/comments/feed/" title="The latest comments to all posts in RSS">Comments <abbr title="Really Simple Syndication">RSS</abbr></a></li> <li><a href="http://wordpress.org/" title="Powered by WordPress, state-of-the-art semantic personal publishing platform.">WordPress.org</a></li> </ul> </div></li> </ul> </div> </div> </div>   <div id="footer"> <div class="page-content"> <div id="copyright"> © 2011, <a href="http://www.dnalc.org">DNA Learning Center</a>, <a href="http://www.cshl.edu">Cold Spring Harbor Laboratory</a>. 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