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href="https://www.linkedin.com/showcase/nci-division-of-cancer-treatment-and-diagnosis/" target="_blank">Follow DCTD on LinkedIn</a></div> </div> <div id="mainColumn" class="clearfix"> <div class="mainContentWrapper"> <div id="pageSectionLinks"><a href="/NewsEvents/default.htm">News & Events</a> <span>|</span> <a href="/NewsEvents/News-2019.htm">2019 News</a></div> <div id="lastupdated">Last Updated: 10/31/2019</div> <h1>NCI-Funded Canine Immunotherapy Trials Network Treats Pet Dogs to Study Cancers Common to Humans</h1> <div class="insetRight"> <img src="20190327_canine_immunotherapy.jpg" alt="Dog patient, Suzzy, treated at Tufts University for diffuse large B cell lymphoma" /> <div class="caption">Dog patient, Suzzy, treated at Tufts University<br />for diffuse large B cell lymphoma</div> </div> <p>In 2017, NCI provided funding in precision medicine oncology to six U.S. veterinary schools of medicine (<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-17-001.html" target="_blank">RFA-CA-17-001</a> and <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-17-002.html" target="_blank">RFA-CA-17-002</a>). These grants, which are part of the <a href="https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative" target="_blank">Cancer Moonshot℠</a>, fund a network of veterinary oncologists and surgeons to enroll pet dogs as patients in immunotherapy clinical trials of cancer.</p> <h2>Network Goal</h2> <p>Promote the development of cancer immunotherapies for several common human cancers — glioma, osteosarcoma, melanoma, and lymphoma — through comparative oncology via a collaborative immunotherapy network</p> <p><strong>The Consortium, called <a href="https://www.precinctnetwork.org/" target="_blank">PRECINCT</a> <a href="http://www.cancer.gov/policies/linking" target="_blank" class="externalLink"><img src="/images/external-link.png" alt="External Link" /></a> — PRE-medical Cancer Immunotherapy Network Canine Trials — consists of a Coordinating Center at the University of Pennsylvania and the following Canine Clinical Trial Sites: </strong></p> <table class="dataTable"> <thead> <tr> <th scope="col">Institution/Principal Investigator(s)</th> <th scope="col">Clinical Trial</th> <th scope="col">Cancer Type</th> <th scope="col">Contact for Canine Patient Enrollment</th> </tr> </thead> <tbody> <tr> <td class="nowrap">University of California, Davis/<br />Robert Canter; Robert Rebhun</td> <td>Enhancing Natural Killer Immunotherapy with First-in-Dog Trials of Inhaled Recombinant IL-15 and Super-agonist IL-15 in Naturally Occurring Canine Cancers</td> <td class="nowrap">Osteosarcoma<br />and Melanoma</td> <td>Teri Guerrero<br />530-752-0125<br /><a href="mailto:tguerrero@ucdavis.edu">tguerrero@ucdavis.edu</a></td> </tr> <tr> <td> <p>University of Alabama at Birmingham (UAB)/<br />M.R. Chambers</p> <p>Consortium includes the<br />following Colleges of<br />Veterinary Medicine:</p> <p>Auburn University<br /> University of Georgia<br /> Mississippi State University<br /> Purdue University<br /> Tuskegee University</p> </td> <td> <p>Canine Immuno-Neurotherapeutics</p> <p>(Combination immunotherapies for canine brain tumors)</p> </td> <td>Glioma</td> <td> <p>Dr. Chambers:<br /><a href="mailto:mrchambers@uabmc.edu">mrchambers@uabmc.edu</a><br />205-481-7939 (Amy Morgan)<br />205-996-7356 (Andrea Shepherd)<br /><a href="https://www.uab.edu/medicine/caninetrial/">Canine Immunoneurotherapeutics Trial</a></p> <p> </p> <p>Dr. Yanke (<a href="mailto:aby003@auburn.edu">aby003@auburn.edu</a>)<br /> Dr. Platt (<a href="mailto:srplatt@uga.edu">srplatt@uga.edu</a>)<br /> Dr. Shores (<a href="mailto:shores@cvm.msstate.edu">shores@cvm.msstate.edu</a>)<br /> Dr. Bentley (<a href="mailto:rbentley@purdue.edu">rbentley@purdue.edu</a>)<br /> Dr. Vig (<a href="mailto:mvig@mytu.tuskegee.edu">mvig@mytu.tuskegee.edu</a>)</p> </td> </tr> <tr> <td>Colorado State University<br />Fort Collins, CO/<br />Steven Dow (CSU)<br />Cheryl London (Tufts)</td> <td>Optimizing Novel Immunotherapy Combinations Targeting the Tumor Microenvironment in Canine Spontaneous Osteosarcoma</td> <td>Osteosarcoma</td> <td>Kara Hall:<br />970-297-4001 <a href="mailto:csuoncologytrials@colostate.edu">csuoncologytrials@colostate.edu</a></td> </tr> <tr> <td>Tufts University<br />N. Grafton, MA/<br />Cheryl London</td> <td>Enhancing the Efficacy of Immunotherapy in DLBCL Using Rational Combination Approaches</td> <td>Lymphoma</td> <td>Diane Welsh:<br /><a href="mailto:Diane.Welsh@tufts.edu">Diane.Welsh@tufts.edu</a></td> </tr> <tr> <td>University of Minnesota<br />St. Paul, MN/<br />Grace Elizabeth Pluhar</td> <td>Novel Combined Immunotherapeutic Strategies for Glioma: Using Pet Dogs as a Large Animal Spontaneous Model</td> <td>Glioma</td> <td>Clinical Investigation Center —<br />Sara Pracht:<br />612-626-3569<br />Or<br />Dr. Liz Pluhar:<br />612-625-1162</td> </tr> </tbody> </table> </div> </div> <div id="columnB"> <div class="branchLinks"> <h3>DCTD Programs</h3> <div><a href="https://brb.nci.nih.gov" target="_blank" class="brp">Biometric Research Program</a></div> <div><a href="http://cdp.cancer.gov/" target="_blank">Cancer Diagnosis Program</a></div> <div><a href="http://imaging.cancer.gov/" target="_blank" class="cip">Cancer Imaging Program</a></div> <div><a href="http://ctep.cancer.gov" target="_blank" class="ctep">Cancer Therapy Evaluation Program</a></div> <div><a href="http://dtp.cancer.gov" target="_blank" class="dtp">Developmental Therapeutics Program</a></div> <div><a href="http://rrp.cancer.gov" target="_blank">Radiation Research Program</a></div> <div><a href="http://trp.cancer.gov" target="_blank">Translational Research Program</a></div> <div><a href="https://proteomics.cancer.gov/" target="_blank">Office of Cancer Clinical Proteomics Research</a></div> <div><a href="http://cam.cancer.gov" target="_blank">Office of Cancer Complementary and Alternative Medicine</a></div> </div> <div id="sidebarTwitter"><a href="https://www.linkedin.com/showcase/nci-division-of-cancer-treatment-and-diagnosis/" target="_blank">Follow DCTD on LinkedIn</a></div> </div> </div> </div> </div> <div id="footer"> <ul> <li><a href="/default.htm">DCTD Home</a></li> <li><a href="/contactUs.htm">Contact DCTD</a></li> <li><a href="/sitemap.htm">Site Map</a></li> <li><a href="https://www.cancer.gov/policies/accessibility" target="_blank">Accessibility</a></li> <li><a href="https://www.cancer.gov/policies/disclaimer" target="_blank">Disclaimer Policy</a></li> <li><a href="https://www.cancer.gov/policies/foia" target="_blank">FOIA</a></li> <li class="last"><a href="https://www.hhs.gov/vulnerability-disclosure-policy" target="_blank">HHS Vulnerability Disclosure</a></li> </ul> <ul id="agencyLinks"> <li><a href="http://www.hhs.gov/" target="_blank">U.S. Department of Health and Human Services</a></li> <li><a href="http://www.nih.gov/" target="_blank">National Institutes of Health</a></li> <li><a href="http://www.cancer.gov/" target="_blank">National Cancer Institute</a></li> <li class="last"><a href="http://www.usa.gov/" target="_blank">USA.gov</a></li> </ul> <div id="bottomTagline">NIH… Turning Discovery Into Health<sup>®</sup></div> </div> </div> <script type="text/javascript"> // resize any image maps along with the image $(document).ready(function(e) { $('img[usemap]').rwdImageMaps(); }); </script>  <script type='text/javascript'> (function(){var g=function(e,h,f,g){ this.get=function(a){for(var a=a+"=",c=document.cookie.split(";"),b=0,e=c.length;b<e;b++){for(var d=c[b];" "==d.charAt(0);)d=d.substring(1,d.length);if(0==d.indexOf(a))return d.substring(a.length,d.length)}return null}; this.set=function(a,c){var b="",b=new Date;b.setTime(b.getTime()+6048E5);b="; expires="+b.toGMTString();document.cookie=a+"="+c+b+"; path=/; "}; this.check=function(){var a=this.get(f);if(a)a=a.split(":");else if(100!=e)"v"==h&&(e=Math.random()>=e/100?0:100),a=[h,e,0],this.set(f,a.join(":"));else return!0;var c=a[1];if(100==c)return!0;switch(a[0]){case "v":return!1;case "r":return c=a[2]%Math.floor(100/c),a[2]++,this.set(f,a.join(":")),!c}return!0}; this.go=function(){if(this.check()){var a=document.createElement("script");a.type="text/javascript";a.src=g;document.body&&document.body.appendChild(a)}}; this.start=function(){var t=this;"complete"!==document.readyState?window.addEventListener?window.addEventListener("load",function(){t.go()},!1):window.attachEvent&&window.attachEvent("onload",function(){t.go()}):t.go()};}; try{(new g(100,"r","QSI_S_ZN_3jWKmtHCom1P33n","https://zn3jwkmthcom1p33n-nci.siteintercept.qualtrics.com/SIE/?Q_ZID=ZN_3jWKmtHCom1P33n")).start()}catch(i){}})(); </script><div id='ZN_3jWKmtHCom1P33n'></div>  </body> </html>

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