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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="9fMEioFQMUuafNbrsqBPnAtBgUa2S_2v-Euzcph3sUMWrbVdkmuMTl9JDDMEH5wVxYsdfzlPktmGOz_8Mfs33Q" /> <meta name="citation_title" content="Acellular Dermis as a Dermal Matrix of Tissue Engineered Skin Substitute for Burns Treatment" /> <meta name="citation_publication_date" content="2016/01/01" /> <meta name="citation_author" content="Nigamananda Dey" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/71116889/Acellular_Dermis_as_a_Dermal_Matrix_of_Tissue_Engineered_Skin_Substitute_for_Burns_Treatment" /> <meta name="twitter:title" content="Acellular Dermis as a Dermal Matrix of Tissue Engineered Skin Substitute for Burns Treatment" /> <meta name="twitter:description" content="The current trend of burn wound care has shifted to a more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. 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This has demanded the emergence of various skin substitutes in the" /> <meta property="article:author" content="https://independent.academia.edu/NigamanandaDey" /> <meta name="description" content="The current trend of burn wound care has shifted to a more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the" /> <title>(PDF) Acellular Dermis as a Dermal Matrix of Tissue Engineered Skin Substitute for Burns Treatment</title> <link rel="canonical" href="https://www.academia.edu/71116889/Acellular_Dermis_as_a_Dermal_Matrix_of_Tissue_Engineered_Skin_Substitute_for_Burns_Treatment" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '107520bac59918e2ceae62eaadd15bff3d1e7904'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1740870094000); window.Aedu.timeDifference = new Date().getTime() - 1740870094000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The current trend of burn wound care has shifted to a more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various etiologies. At present, there is no ideal skin substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesized on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent reepithelialization characteristics due to the presence...","author":[{"@context":"https://schema.org","@type":"Person","name":"Nigamananda Dey","url":"https://independent.academia.edu/NigamanandaDey","sameAs":[]}],"contributor":[],"dateCreated":"2022-02-11","dateModified":"2022-02-12","datePublished":"2016-01-01","headline":"Acellular Dermis as a Dermal Matrix of Tissue Engineered Skin Substitute for Burns 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This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various etiologies. At present, there is no ideal skin substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesized on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. 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const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=71116889"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The current trend of burn wound care has shifted to a more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various etiologies. At present, there is no ideal skin substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesized on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent reepithelialization characteristics due to the presence...</p><div class="ds-work-card--button-container"><div class="primary-buttons "><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":80605184,"attachmentType":"pdf","workUrl":"https://www.academia.edu/71116889/Acellular_Dermis_as_a_Dermal_Matrix_of_Tissue_Engineered_Skin_Substitute_for_Burns_Treatment"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span>See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":80605184,"attachmentType":"pdf","workUrl":"https://www.academia.edu/71116889/Acellular_Dermis_as_a_Dermal_Matrix_of_Tissue_Engineered_Skin_Substitute_for_Burns_Treatment"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas" data-impression-entity-id="71116889" data-impression-entity-type="2" data-impression-source="signup-banner"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various etiologies. At present, there is no ideal skin substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesized on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent re-epithelialization characteristics due to the presence of a basement membrane. Acellular dermal scaffold are one of the types of biological skin substitutes which has the extracellular matrix (ECM) almost like the normal skin extracellular matrix. For regeneration and healing of deep burn wound, ECM plays a very important role in rapid healing with minimum scar. Although some acellular dermis based products are available in foreign market, their prohibitive high cost prevents the Indian patient population to use it. Hence, this Method was designed to prepare an acellular dermis, indigenously, suitable for clinical application. NaOH method was used to standardize the decellularization method. In our observation, six weeks of decellularization was sufficient to completely decellularize the skin as confirmed by H&E Staining. Also, it was found out to be biocompatible by cell culture assay.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Annals of Public Health and Research Acellular Dermis as a Dermal Matrix of Tissue Engineered Skin Substitute for Burns Treatment","attachmentId":49729897,"attachmentType":"pdf","work_url":"https://www.academia.edu/29284333/Annals_of_Public_Health_and_Research_Acellular_Dermis_as_a_Dermal_Matrix_of_Tissue_Engineered_Skin_Substitute_for_Burns_Treatment","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/29284333/Annals_of_Public_Health_and_Research_Acellular_Dermis_as_a_Dermal_Matrix_of_Tissue_Engineered_Skin_Substitute_for_Burns_Treatment"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="96980241" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96980241/Biologic_and_synthetic_skin_substitutes_An_overview">Biologic and synthetic skin substitutes: An overview</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="257735943" href="https://independent.academia.edu/AhmadHalim73">Ahmad Halim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Indian Journal of Plastic Surgery, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various aetiologies. At present, there is no ideal substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesised on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent re-epithelialisation characteristics due to the presence of a basement membrane. Synthetic skin substitutes demonstrate the advantages of increase control over scaffold composition. The ultimate goal is to achieve an ideal skin substitute that provides an effective and scar-free wound healing.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Biologic and synthetic skin substitutes: An overview","attachmentId":98728569,"attachmentType":"pdf","work_url":"https://www.academia.edu/96980241/Biologic_and_synthetic_skin_substitutes_An_overview","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/96980241/Biologic_and_synthetic_skin_substitutes_An_overview"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="21827929" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21827929/Preparation_and_Characterization_of_a_Novel_Skin_Substitute">Preparation and Characterization of a Novel Skin Substitute</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43051757" href="https://independent.academia.edu/CarlottaCastagnoli">Carlotta Castagnoli</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43102530" href="https://independent.academia.edu/CarlaPezzuto">Carla Pezzuto</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biomedicine and Biotechnology, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Autologous epidermal cell cultures (CEA) represent a possibility to treat extensive burn lesions, since they allow a significative surface expansion which cannot be achieved with other surgical techniques based on autologous grafting. Moreover currently available CEA preparations are difficult to handle and their take rate is unpredictable. This study aimed at producing and evaluating a new cutaneous biosubstitute made up of alloplastic acellular glycerolized dermis (AAGD) and CEA to overcome these difficulties. A procedure that maintained an intact basement membrane was developed, so as to promote adhesion and growth of CEA on AAGD. Keratinocytes were seeded onto AAGD and cultured up to 21 days. Viability tests and immunohistochemical analysis with specific markers were carried out at 7, 14, and 21 days, to evaluate keratinocyte adhesion, growth, and maturation. Our results support the hypothesis that this newly formed skin substitute could allow its permanent engraftment in clinical application.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Preparation and Characterization of a Novel Skin Substitute","attachmentId":42579121,"attachmentType":"pdf","work_url":"https://www.academia.edu/21827929/Preparation_and_Characterization_of_a_Novel_Skin_Substitute","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/21827929/Preparation_and_Characterization_of_a_Novel_Skin_Substitute"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="127360567" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/127360567/Tissue_engineering_for_full_thickness_burns_A_dermal_substitute_from_bench_to_bedside">Tissue engineering for full-thickness burns: A dermal substitute from bench to bedside</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="331108817" href="https://independent.academia.edu/DelphineBouard">Delphine Bouard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Our aim was to obtain a viable and easily available dermal substitute (DS) for the definitive coverage of full-thickness burns. A DS composed of a collagen-glycosaminoglycan-chitosan dermal matrix (DM) colonized with foreskin fibroblasts (FF) is described. FF-colonized DS were compared to the DM seeded with adult dermal fibroblasts (DF). FF-colonized DS expressed more fibrillin and tropoelastin than that with DF. Reconstructed skin obtained with both FF-and DF-colonized DS similarly expressed laminin-5 and collagen VII at the dermal-epidermal junction. Both FF-and DF-colonized DS produced cutaneous wound healing mediators in a dose-dependent manner in the presence of platelet lysate. After freeze-thawing, the FF-colonized DS were recovered in culture and retained their ability to produce vascular endothelial growth factor. Grafting of DS into nude rats achieved a complete healing of a dermal-epidermal lesion with a good epidermalization.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue engineering for full-thickness burns: A dermal substitute from bench to bedside","attachmentId":121103310,"attachmentType":"pdf","work_url":"https://www.academia.edu/127360567/Tissue_engineering_for_full_thickness_burns_A_dermal_substitute_from_bench_to_bedside","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/127360567/Tissue_engineering_for_full_thickness_burns_A_dermal_substitute_from_bench_to_bedside"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="17809204" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17809204/Tissue_engineering_of_cultured_skin_substitutes">Tissue engineering of cultured skin substitutes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37732417" href="https://independent.academia.edu/RHorch">Raymund Horch</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cellular and Molecular Medicine, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">Skin replacement has been a challenging task for surgeons ever since the introduction of skin grafts by Reverdin in 1871. Recently, skin grafting has evolved from the initial autograft and allograft preparations to biosynthetic and tissue-engineered living skin replacements. This has been fostered by the dramatically improved survival rates of major burns where the availability of autologous normal skin for grafting has become one of the limiting factors. The ideal properties of a temporary and a permanent skin substitute have been well defined. Tissue-engineered skin replacements: cultured autologous keratinocyte grafts, cultured allogeneic keratinocyte grafts, autologous/allogeneic composites, acellular biological matrices, and cellular matrices including such biological substances as fibrin sealant and various types of collagen, hyaluronic acid etc. have opened new horizons to deal with such massive skin loss. In extensive burns it has been shown that skin substitution with cultured grafts can be a life-saving measure where few alternatives exist. Future research will aim to create skin substitutes with cultured epidermis that under appropriate circumstances may provide a wound cover that could be just as durable and esthetically acceptable as conventional split-thickness skin grafts. Genetic manipulation may in addition enhance the performance of such cultured skin substitutes. If cell science, molecular biology, genetic engineering, material science and clinical expertise join their efforts to develop optimized cell culture techniques and synthetic or biological matrices then further technical advances might well lead to the production of almost skin like new tissue-engineered human skin products resembling natural human skin.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue engineering of cultured skin substitutes","attachmentId":42227843,"attachmentType":"pdf","work_url":"https://www.academia.edu/17809204/Tissue_engineering_of_cultured_skin_substitutes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17809204/Tissue_engineering_of_cultured_skin_substitutes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="91223308" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91223308/The_use_of_an_acellular_matrix_derived_from_human_dermis_for_the_treatment_of_full_thickness_skin_wounds">The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36368760" href="https://independent.academia.edu/ElenaBondioli">Elena Bondioli</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cell and Tissue Banking, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Full-thickness skin wounds occur in many different clinical cases and the use of biological acellular dermal matrices (ADMs) to reconstruct the damaged area is increasing in the field of plastic and reconstructive surgery. In particular, the ability of ADMs to maintain the structural properties of extracellular matrix as well as to provide a suitable environment for cell growth makes their use suitable for the improvement of wound healing and the reduction of side effects deriving from contracture and scar tissue formation. In this study, we describe the clinical use of a recently developed human dermal matrix (HDM) in combination with graft skin as an alternative reconstructive solution for the treatment of fullthickness skin wounds. The HDM was applied in combination with autologous graft skin on three different clinical cases in which full-thickness skin wounds occurred. The clinical outcomes were evaluated in the patients during their follow-up. Histological as well as ultra-structural analysis were also performed on skin biopsy of the clinical case 3 one year after the treatment with HDM. The use of HDM stimulates the wound healing process in all clinical cases of full-thickness skin wounds here described with a functional and aesthetic rescue of the damaged area. Histological and ultra-structural analysis show a regenerative healing of the wound area with well-organized/oriented connective tissue in which cellular infiltration as well as blood vessels are evident. Our results support the clinical use of HDM as a permanent dermal replacement for the treatment of full-thickness skin wounds.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds","attachmentId":94570715,"attachmentType":"pdf","work_url":"https://www.academia.edu/91223308/The_use_of_an_acellular_matrix_derived_from_human_dermis_for_the_treatment_of_full_thickness_skin_wounds","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/91223308/The_use_of_an_acellular_matrix_derived_from_human_dermis_for_the_treatment_of_full_thickness_skin_wounds"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="100489819" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/100489819/Skin_Tissue_Engineering_Advances_in_Burns_A_Brief_Introduction_to_the_Past_the_Present_and_the_Future_Potential">Skin Tissue Engineering Advances in Burns: A Brief Introduction to the Past, the Present, and the Future Potential</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="149833915" href="https://independent.academia.edu/farazchogan">faraz chogan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Burn Care &amp; Research</p><p class="ds-related-work--abstract ds2-5-body-sm">Burn injuries are a severe form of skin damage with a significant risk of scarring and systemic sequelae. Approximately 11 million individuals worldwide suffer burn injuries annually, with 180,000 people dying due to their injuries. Wound healing is considered the main determinant for the survival of severe burns and remains a challenge. The surgical treatment of burn wounds entails debridement of necrotic tissue, and the wound is covered with autologous skin substitutes taken from healthy donor areas. Autologous skin transplantation is still considered to be the gold standard for wound repair. However, autologous skin grafts are not always possible, especially in cases with extensive burns and limited donor sites. Allografts from human cadaver skin and xenografts from pig skin may be used in these situations to cover the wounds temporarily. Alternatively, dermal analogs are used until permanent coverage with autologous skin grafts or artificial skins can be achieved, requiring stag...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Skin Tissue Engineering Advances in Burns: A Brief Introduction to the Past, the Present, and the Future Potential","attachmentId":101299606,"attachmentType":"pdf","work_url":"https://www.academia.edu/100489819/Skin_Tissue_Engineering_Advances_in_Burns_A_Brief_Introduction_to_the_Past_the_Present_and_the_Future_Potential","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/100489819/Skin_Tissue_Engineering_Advances_in_Burns_A_Brief_Introduction_to_the_Past_the_Present_and_the_Future_Potential"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="115210386" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/115210386/Production_of_a_Bilayered_Self_Assembled_Skin_Substitute_Using_a_Tissue_Engineered_Acellular_Dermal_Matrix">Production of a Bilayered Self-Assembled Skin Substitute Using a Tissue-Engineered Acellular Dermal Matrix</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41102471" href="https://independent.academia.edu/DanielleLarouche">Danielle Larouche</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Tissue Engineering Part C-methods, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Our bilayered self-assembled skin substitutes (SASS) are skin substitutes showing a structure and functionality very similar to native human skin. These constructs are used, in life threatening burn wounds, as permanent autologous grafts for the treatment of such affected patients even though their production is exacting. We thus intended to shorten their current production time to improve their clinical applicability. A self-assembled decellularized dermal matrix was used. It allowed the production of an autologous skin substitute from patient's cells. The characterization of SASS reconstructed using a decellularized dermal matrix (SASS-DM) was performed by histology, immunofluorescence, transmission electron microscopy and uniaxial tensile analysis. Using the SASS-DM, it was possible to reduce the standard production time from about eight to four weeks and a half. The structure, cell differentiation and mechanical properties of the new skin substitutes were shown to be similar to the SASS. The decellularization process had no influence on the final microstructure and mechanical properties of the dermal matrix. This model, by enabling the production of a skin substitute in a shorter time frame without compromising its intrinsic tissue properties, represents a promising addition to the currently available burn and wound treatments.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Production of a Bilayered Self-Assembled Skin Substitute Using a Tissue-Engineered Acellular Dermal Matrix","attachmentId":111684538,"attachmentType":"pdf","work_url":"https://www.academia.edu/115210386/Production_of_a_Bilayered_Self_Assembled_Skin_Substitute_Using_a_Tissue_Engineered_Acellular_Dermal_Matrix","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/115210386/Production_of_a_Bilayered_Self_Assembled_Skin_Substitute_Using_a_Tissue_Engineered_Acellular_Dermal_Matrix"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="54928158" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54928158/Advances_in_Skin_Substitutes_Potential_of_Tissue_Engineered_Skin_for_Facilitating_Anti_Fibrotic_Healing">Advances in Skin Substitutes—Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="25628305" href="https://independent.academia.edu/MathewVarkey">Mathew Varkey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Functional Biomaterials, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Skin protects the body from exogenous substances and functions as a barrier to fluid loss and trauma. The skin comprises of epidermal, dermal and hypodermal layers, which mainly contain keratinocytes, fibroblasts and adipocytes, respectively, typically embedded on extracellular matrix made up of glycosaminoglycans and fibrous proteins. When the integrity of skin is compromised due to injury as in burns the coverage of skin has to be restored to facilitate repair and regeneration. Skin substitutes are preferred for wound coverage when the loss of skin is extensive especially in the case of second or third degree burns. Different kinds of skin substitutes with different features are commercially available; they can be classified into acellular skin substitutes, those with cultured epidermal cells and no dermal components, those with only dermal components, and tissue engineered substitutes that contain both epidermal and dermal components. Typically, adult wounds heal by fibrosis. Most organs are affected by fibrosis, with chronic fibrotic diseases estimated to be a leading cause of morbidity and mortality. In the skin, fibroproliferative disorders such as hypertrophic scars and keloid formation cause cosmetic and functional problems. Dermal fibroblasts are understood to be heterogeneous; this may have implications on post-burn wound healing since studies have shown that superficial and deep dermal fibroblasts are anti-fibrotic and</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Advances in Skin Substitutes—Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing","attachmentId":71049686,"attachmentType":"pdf","work_url":"https://www.academia.edu/54928158/Advances_in_Skin_Substitutes_Potential_of_Tissue_Engineered_Skin_for_Facilitating_Anti_Fibrotic_Healing","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54928158/Advances_in_Skin_Substitutes_Potential_of_Tissue_Engineered_Skin_for_Facilitating_Anti_Fibrotic_Healing"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="92024346" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92024346/Dermal_Matrices_and_Bioengineered_Skin_Substitutes">Dermal Matrices and Bioengineered Skin Substitutes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="248175546" href="https://independent.academia.edu/KAbberton">Keren Abberton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Plastic and Reconstructive Surgery Global Open, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">or many centuries, skin grafts have been used to restore wound defects after trauma, vascular disease, or cancer. However, availability of sufficient healthy skin can be an issue, as well as the additional health risks associated with the procedure. The deforming donor-site morbidity should also be considered when opting for skin grafting. Disadvantages as such have led to innovations in skin tissue engineering. Over recent decades, scientists and surgeons have collaborated to develop various bioengineered and synthetic alternatives to promote healing in superficial and deep skin wounds. Tissue-engineered skin scaffolds are 3-dimensional structures that are positioned within the defect and provide immediate protection against dehydration, microorganisms, and toxins. 1 The scaffold then gradually becomes incorporated in the wound bed, a process aided by natural wound healing mechanisms such as local inflammation, cell infiltration (neutrophils, macrophages, and fibroblasts), and neovascularization of the scaffold. More recent advances in skin substitutes involve prepopulation of scaffolds with living cells of autologous or allogeneic origin, usually keratinocytes or fibroblasts.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dermal Matrices and Bioengineered Skin Substitutes","attachmentId":95145865,"attachmentType":"pdf","work_url":"https://www.academia.edu/92024346/Dermal_Matrices_and_Bioengineered_Skin_Substitutes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92024346/Dermal_Matrices_and_Bioengineered_Skin_Substitutes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":80605184,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":80605184,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_80605184" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="56616404" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56616404/Bioengineered_Skin_Substitutes_Advances_and_Future_Trends">Bioengineered Skin Substitutes: Advances and Future Trends</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="151812052" href="https://independent.academia.edu/AgnesKlar">Agnes Klar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Applied Sciences</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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data-entity-id="63365048" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63365048/Engineered_skin_substitutes_practices_and_potentials">Engineered skin substitutes: practices and potentials</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45981986" href="https://independent.academia.edu/DorothySupp">Dorothy Supp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinics in Dermatology, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Engineered skin substitutes: practices and 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href="https://www.academia.edu/25583452/Tissue_engineered_skin_substitutes_an_overview">Tissue-engineered skin substitutes: an overview</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49118691" href="https://uniupo.academia.edu/BarbaraAzzimonti">Barbara Azzimonti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Artificial Organs, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue-engineered skin substitutes: an overview","attachmentId":45912760,"attachmentType":"pdf","work_url":"https://www.academia.edu/25583452/Tissue_engineered_skin_substitutes_an_overview","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/25583452/Tissue_engineered_skin_substitutes_an_overview"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="38767694" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38767694/The_use_of_dermal_substitutes_in_burn_surgery_Acute_phase">The use of dermal substitutes in burn surgery: Acute phase</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="107299982" href="https://salvador.academia.edu/SilvinaAranda">Silvina Aranda</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Dermal Substitutes, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The use of dermal substitutes in burn surgery: Acute phase","attachmentId":58856761,"attachmentType":"pdf","work_url":"https://www.academia.edu/38767694/The_use_of_dermal_substitutes_in_burn_surgery_Acute_phase","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/38767694/The_use_of_dermal_substitutes_in_burn_surgery_Acute_phase"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="34333391" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/34333391/A_guide_to_biological_skin_substitutes">A guide to biological skin substitutes</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="67552801" href="https://independent.academia.edu/JonesIsabel">Isabel Jones</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British Journal of Plastic Surgery, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A guide to biological skin 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href="https://www.academia.edu/115210333/Improved_Methods_to_Produce_Tissue_Engineered_Skin_Substitutes_Suitable_for_the_Permanent_Closure_of_Full_Thickness_Skin_Injuries">Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41102471" href="https://independent.academia.edu/DanielleLarouche">Danielle Larouche</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BioResearch Open Access, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin 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